Graduate Program in Pharmacology and Toxicology Bob Speth, Chair. Department of Pharmacology School of Pharmacy University of Mississippi

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1 Graduate Program in Pharmacology and Toxicology Bob Speth, Chair Department of Pharmacology School of Pharmacy University of Mississippi

2 Graduate Student Population in Dept of Pharmacology Total students = 12 + Incoming Fall 2005 = 3 students = 11 candidates = 3 Masters students = 1 Domestic = 3 Foreign = 11 Underrepresented minority students = 1 9 female 3 male Average 12 month stipend $14,750 90% tuition rebate Student health medical coverage

3 Graduate Student Population in Dept of Pharmacology Support Mechanisms State of Mississippi $76,000 /yr 4 teaching assistantships at $8,500 / 9 months 3 research assistantships at $10,000 / yr 1 research assistantship at $12,000 / yr (from National Center for Natural Products Research Faculty research funds $104,000 / yr (includes F&A returns to Dept. Pharmacology)

4 Didactic Course Requirements Pharmaceutical Sciences with specialization in Pharmacology 1. Introduction to Pharmacology I & II, (PHCL 563, 564), 4,4 hrs 2. Principles of Life Science Research (PHCL 501) 1 hr (Based on Frank Macrina s Scientific Integrity text) 3. General Principles of Pharmacology and Toxicology I, II (PHCL 675, 676), 4,4 hrs 4. Physiological Chemistry (PHCL 669), 4 hrs 5. Advanced Physiology (PHCL 661), 4 hrs 6. Biometry and Experimental Design & Analysis (BISC 504) or Statistics I (PSY 501 or equivalent) 3 hrs

5 Masters 1. Introduction to Pharmacology I & II, (PHCL 563, 564), 4,4 hrs 2. Principles of Life Science Research (PHCL 501) 1 hr (Based on Frank Macrina s Scientific Integrity text) 3. General Principles of Pharmacology and Toxicology I, II (PHCL 675, 676), 4,4 hrs 4. Physiological Chemistry (PHCL 669), 4 hrs 5. Advanced Physiology (PHCL 661), 4 hrs 6. Biometry and Experimental Design & Analysis (BISC 504) or Statistics I (PSY 501 or equivalent) 3 hrs

6 Didactic Course Requirements 1. Introduction to Pharmacology I & II, (PHCL 563, 564), 4,4 hrs Same as professional Pharmacy student curriculum Basic and Clinical Pharmacology I (PHCL 443, 4 cr hr) and II (PHCL 444, 4 cr hr) Text: Katzung Basic and Clinical Pharmacology Additional requirement for graduate students: to present a 20 minute oral presentation on a topic in Pharmacology that is not covered in the courses Pharmacology graduate students take this course in their first year of graduate school

7 1. Introduction to Pharmacology I & II, (PHCL 563, 564), 4,4 hrs (Continued) Note: Antibiotics, antiparasitics, antivirals, anticancer agents, and pharmacokinetics are not covered in PHCL These topics are covered in separate courses given in the departments of Pharmacognosy and Pharmaceutics.

8 3. General Principles of Pharmacology and Toxicology I, II (PHCL 675, 676), 4,4 hrs Enrollment is primarily Pharmacology Graduate students Texts: Casarett & Doull s Toxicology; Goodman & Gilman s The Pharmacological Basis of Therapeutics; Course series is offered on an alternate year basis Rotates with a graduate Biochemistry class Physiological Chemistry (PHCL 669, 4 cr hr) and a graduate Physiology class Advanced Physiology (PHCL 661, 4 cr hr) taught by Pharmacology Department Faculty

9 3. General Principles of Pharmacology and Toxicology I (PHCL 675), 4 hrs Molecular aspects of Pharmacology and Toxicology Drug and toxin ADME with heavy emphasis on biotransformation and toxicokinetics P450 s Phase II metabolism Chemical Carcinogens and carcinogenesis Mutagenesis and teratogenesis Genetic toxicology Developmental toxicology Oxidative stress

10 General Principles of Pharmacology and Toxicology I (PHCL 675), 4 hrs Molecular aspects of Pharmacology and Toxicology Dose response relationships Receptor activation and transduction Receptor binding kinetics agonists/antagonists/partial and inverse agonists Receptor classification and functionality» Cholinergic, adrenergic, serotonergic, excitatory and inhibitory amino acids» Intracellular signaling pathways

11 General Principles of Pharmacology and Toxicology I (PHCL 675), 4 hrs Grading 2 exams and a final exam Quizzes Attendence and participation Major oral presentation

12 General Principles of Pharmacology and Toxicology II (PHCL 676), 4 hrs Toxicology of organ systems Drugs, chemicals, and environmental agents as toxins Team-taught by Pharmacology Dept faculty including adjunct and joint faculty Grading Written exams Midterm and final Oral presentation and ~ 10 page research paper on chosen topic

13 Advanced Physiology (PHCL 661), 4 hrs Physiology of individual organ systems Additional focus on pathophysiology of organ systems in contrast to normal physiology Interrelationships of individual organ systems Grading Written exams Midterm and final Oral presentation and ~ 10 page research paper on chosen topic

14 Physiological Chemistry (PHCL 669), 4 hrs Structure and function of carbohydrates, proteins, nucleic acids Enzymatic catalysis, intermediary metabolism Membrane structure Grading Written exams Midterm and final Oral presentation and research paper on chosen topic

15 The End?s

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