Projektnummer Projekttitel. Numéro du projet Titre du projet. KLS Cellular analysis of tumour neoangiogenesis in the zebrafish embryo

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1 Forschungsprojekte 2013 Projets de recherche 2013 Unterstützt von: / Soutenus par: Grundlagenforschung / Recherche fondamentale Affolter Markus, Prof. Dr. Biozentrum Universität Basel 4056 Basel KLS Cellular analysis of tumour neoangiogenesis in the zebrafish embryo Gilliet Michel, Prof. Dr. Dermatologie Centre hospitalier universitaire vaudois (CHUV) 1011 Lausanne KLS Targeting intracellular nucleic acid receptors for melanoma immunotherapy Hantschel Oliver, Prof. Dr. ISREC EPF de Lausanne 1015 Lausanne KLS Identification and targeting of allosteric regulatory sites in oncogenic cytoplasmic tyrosine kinases Levesque Mitchell, Dr. Dermatologische Klinik KLS Functional genomics of melanoma heterogeneity and invasion Weller Michael, Prof. Dr. med. Klinik für Neurologie KLS CD317 immunotoxin therapy for glioblastoma

2 Klinische Forschung / Recherche clinique Kalberer Christian, PD Dr. Diagnostische Hämatologie Universitätsspital Basel KLS Immunotherapy with mega doses of activated natural killer cells in haematopoietic malignancies and follow-up analysis of in vivo cell migration and survival Nadal David, Prof. Dr. Abteilung Infektiologie und Spitalhygiene Kinderspital Zürich 8032 Zürich KLS Translational research with the goal to identify, characterize and target B-ALLspecific and Burkitt s lymphoma-specific T- helper cells Rechsteiner Markus, Dr. Institut für Klinische Pathologie KLS Non-invasive identification of VHL mutations in plasma by deep-sequencing with subsequent assessment of mutant pvhl functionality in FFPE by FRET-FLIM in ccrcc patients Reyes Mauricio, PD Dr. Institut für Chirurgische Technologien und Biomechanik (ISTB) Universität Bern 3014 Bern KLS Medical image analysis for brain tumour studies von der Weid Nicolas, Prof. Dr. Onkologie/Hämatologie Universitäts-Kinderklinik beider Basel (UKBB) KLS Effects of a 1-year partially supervised exercise programme in childhood cancer survivors a randomized controlled trial

3 Psychosoziale Forschung / Recherche psychosociale Zwahlen Diana, Dr. phil. Psychosomatik Abteilung Universitätsspital Basel KLS Understanding why cancer patients accept or turn down psycho-oncological support. A prospective observational study including patients and clinicians perspective on communication about distress Epidemiologische Forschung / Recherche épidémiologique Guessous Idris, Dr Département de médecine communautaire, de premier recours et des urgences Hôpitaux universitaires de Genève (HUG) 1211 Genève KLS Socio-demographic and socioeconomic inequalities in cancer screening, Switzerland : trend analyses based on the Swiss Health Survey Stöckli Sandro, Prof. Dr. Hals-Nasen-Ohrenklinik Kantonsspital St. Gallen (KSSG) 9007 St. Gallen KLS Impact of human papillomavirus (HPV) infection on outcome in surgically treated patients with oropharyngeal squamous cell carcinoma (OPSCC)

4 Stipendien 2013 Bourses 2013 Unterstützt von: / Soutenus par: Fisher Oliver, Dr. med. Klinik für Viszeral- und Transplantationschirurgie BIL KLS Prognostic biomarkers and long non-coding RNA in esophageal adenocarcinoma Destination: St. Vincent s Centre for Applied Medical Research, University of New South Wales, Darlinghurst, AUS Gonseth Nusslé Semira, Dr med. Centre hospitalier universitaire vaudois (CHUV) 1005 Lausanne BIL KLS Association between parental folate intake and specific epigenetic patterns in children with acute lymphoblastic leukaemia Destination: Division of Cancer Epidemiology, Department of Epidemiology & Biostatistics, University of California, San Francisco, USA Rozenholc Alexandre, Dr med. Hôpitaux universitaires de Genève (HUG) 1211 Genève BIL KLS Blue dye only vs blue dye + technetium for sentinel node procedure in endometrial cancer Destination: Centre Hospitalier Universitaire de Montréal (CHUM), Hôpital Notre-Dame Pavillon L-C Simard, Montréal (Québec), CAN

5 Forschungsprojekte 2013 Projets de recherche 2013 Unterstützt von: / Soutenus par: Grundlagenforschung / Recherche fondamentale Auwerx Johan, Prof. Dr Laboratory of Integrative and Systems Physiology EPF de Lausanne 1015 Lausanne KFS The role of the sirtuin ageing proteins on the development of colorectal cancer Bachmann Martin, Dr. Dermatologische Klinik KFS Bispecific anti-tumour antibodies: combining tumour-specificity with cytokine agonism Caflisch Amedeo, Prof. Dr. Biochemisches Institut Universität Zürich 8057 Zürich KFS Development of ATAD2 bromodomain inhibitors to fight breast and lung cancer Carbone Giuseppina, Dr Laboratorio di oncologia sperimentale Istituto oncologico della Svizzera italiana (IOSI) 6500 Bellinzona KFS Deregulated ETS transcriptional network and clinical implications for prostate cancer progression Cejka Petr, Prof. Dr. Institut für Molekulare Krebsforschung Universität Zürich 8057 Zürich KFS Maintenance of genome stability by hdna2 in complex with BLM or WRN proteins Clavien Pierre-Alain, Prof. Dr. Klinik für Viszeral- und Transplantationschirurgie KFS lnositol tris-pyrophosphate (ITPP) and its anti-hypoxic potential in colorectal metastases of the liver

6 Dormond Olivier, Dr Service de chirurgie viscérale Centre hospitalier universitaire vaudois (CHUV) 1011 Lausanne KFS Mechanisms of acquired resistance of cancer cells to PI3K inhibition Fajas Lluis, Prof. Département de physiologie Université de Lausanne 1005 Lausanne KFS Cancer-induced metabolic changes in the host organism: beyond the Warburg effect Foti Michelangelo, Prof. Dept. Physiologie cellulaire et métabolisme Université de Genève 1206 Genève KFS Role of mir-22 in hepatocellular carcinoma Hall Jonathan, Prof. Institut für Pharmazeutische Wissenschaften, ETH Zürich 8093 Zürich KFS Targeting the Lin28/pre-let-7 interaction in cancer Huelsken Joerg, Prof. Dr. Faculté de sciences de la vie ISREC EPF de Lausanne 1015 Lausanne KFS Immunotherapy against cancer stem cells Lefort Karine, Dr Service de dermatologie et de vénérologie Centre hospitalier universitaire vaudois (CHUV) 1066 Epalinges KFS Notch signalling in lung squamous cell carcinoma Michielin Olivier, Prof. Dr Service d d oncologie médicale Centre hospitalier universitaire vaudois (CHUV) 1011 Lausanne KFS Adoptive cell transfer for stage IV melanoma using rationally designed TCR Müller Antonia, Dr. med. Klinik für Hämatologie Universitäts Spital Zürich KFS Improving graft-versus-tumour effects by donor vaccination with WT1-peptide and transplantation of tailored haematopoietic grafts Münz Christian, Prof. Institut für Experimentelle Immunologie Universität Zürich 8057 Zürich KFS Collaboration of Epstein Barr virus and Kaposi Sarcoma associated herpes virus during lymphomagenesis Schäfer Beat W., Prof. Abteilung Onkologie Kinderspital Zürich 8032 Zürich KFS Novel in vivo models of rhabdomyosarcoma tumourigenesis

7 Swartz Melody, Dr Institut interfacultaire de bioingénierie EPF de Lausanne 1015 Lausanne KFS Targeting tumour-associated lymphatics for cancer immunotherapy Thome-Miazza Margot, Prof. Faculté de biologie et de médecine Université de Lausanne 1066 Epalinges KFS Identification of a ubiquitin ligase driving lymphomagenesis Tritschler Isabel, Dr. Klinik für Neurologie 8008 Zürich KFS TGF-β family members and pro-protein convertases: potential therapeutic targets in glioblastoma? van den Broek Maries, Prof. Dr. Institut für Experimentelle Immunologie Universität Zürich 8952 Zürich KFS The role of immune defense and platelets in the development of spontaneous metastases Zaugg Kathrin, Dr. med. et Dr. sc. nat. Universitätsklinik für Radio- Onkologie, Inselspital Universitätsspital Bern KFS Dose-rate effect of novel radiation technologies: relevance for the clinical use

8 Klinische Forschung / Recherche clinique Aebersold Rudolf, Prof. Dr. Institut für Molekulare Systembiologie ETH Zürich 8093 Zürich KFS Molecular subclassification of non small-cell lung cancer by quantitative kinome interactome analysis Bairoch Amos, Prof. Sciences des protéines humaines Université de Genève 1211 Genève KFS Improving clinical interpretation of genetic variations underlying common cancers Dietrich Pierre-Yves, Prof. Dpt de médecine interne Hôpitaux universitaires de Genève (HUG) 1211 Genève KFS Development of chimeric antigen receptor T-cells for immunotherapy of glioma Fix Michael, PD Dr. Universitätsklinik für Radio- Onkologie, Inselspital Universitätsspital Bern KFS Dosimetric evaluation and secondary cancer risk of modulated electron radiotherapy Gerber Nicolas, Dr. Departement Onkologie Kinderspital Zürich 8032 Zürich KFS SIOP CNS GCT II: prospective trial for the diagnosis and treatment of children, adolescents and young adults with intracranial germ cell tumours Irminger-Finger Irmgard, Dr. gynécologie-obstétrique Hôpitaux universitaires de Genève (HUG) 1225 Genève KFS BARD1, a molecular target for prostate cancer screening and therapy Krenger Werner, PD Dr. phil. II Departement Biomedizin Universität Basel 4058 Basel KFS Role of sphingosine-1-phosphate (S1P) receptor agonism in engraftment, T-cell regeneration and anti-tumour immunity in preclinical and clinical haematopoietic stem cell transplantation Kruithof Egbert, Prof. Dr Service d'angiologie et d'hémostase Hôpitaux universitaires de Genève (HUG) 1211 Genève KFS Regulation of procoagulant activities of acute promyelocytic leukaemia cells

9 Langer Rupert, PD Dr. Institut für Pathologie Universität Bern KFS The impact of autophagy on biology and chemo-resistance of esophageal adenocarcinomas Lugli Alessandro, Prof. Dr. med. Institut für Pathologie Universität Bern KFS micrornas in the tumour microenvironment of colorectal cancer: novel targets for therapeutic intervention? Matter Matthias, Dr. Dr. med. et phil nat. Institut für Pathologie Universitätsspital Basel KFS Identification of mechanisms that promote liver cancer Mazzucchelli Luca, Prof. Dr Istituto cantonale di patologia (ICP) 6601 Locarno KFS MYC activation in diffuse large B-cell lymphomas Petrausch Ulf, Dr. Klinik für Immunologie KFS Phase I study for the adoptive transfer of redirected FAP-specific T-cells in the pleural effusion of patients with malignant pleural mesothelioma Rottenburger Christof, Dr. med. Abteilung Nuklearmedizin Universitätsspital Basel KFS Lu-PP-F11N for receptor targeted therapy and imaging (theranostics) of metastatic medullary thyroid cancer a pilot and a phase I study Simon Hans-Uwe, Prof. Dr. Institut für Pharmakologie Universität Bern KFS Characterization of ATG5 as a tumour suppressor in cutaneous melanoma Tausch Christoph, Dr. med. Brust-Zentrum Zürich 8008 Zürich KFS Randomized controlled trial to evaluate the impact of a surgical sealing patch on lymphatic drainage after axillary lymph node dissection for breast cancer Theocharides Alexandre, Dr. med. Klinik für Hämatologie KFS The CD47-SIRPα interaction and the role of ikaros in myeloproliferative neoplasms Tornillo Luigi, PD Dr. med. Institut für Pathologie Universitässpital Basel 4003 Basel KFS Understanding the molecular mechanisms of differential responses to anti-angiogenic treatment in colorectal cancer

10 von Gunten Stephan, PD Dr. Institut für Pharmakologie Universität Bern KFS Siglec-7/-9 ligand receptor interactions in NK cell-mediated tumour immunosurveillance Zajac Paul, PD Dr. Departement Biomedizin Universitätsspital Basel KFS Investigator-initiated phase I immunotherapy trial for patients bearing non-small cell lung cancers expressing cancer/testis tumour antigens and treated with a non-replicating vaccinia virus encoding for 7 antigenic epitopes, CD80 and CD154 co-stimulatory

11 Psychosoziale Forschung / Recherche psychosociale Baumgartner Edgar, Prof. Dr. Hochschule für Soziale Arbeit Fachhochschule Nordwestschweiz 4600 Olten KFS The effect of social counselling services on quality of life and coping with burden of parents of a child with cancer. A randomized intervention study at the University Paediatric Clinic Zurich Eicher Manuela, Dr. rer. med. Recherche & développement Haute école de santé Fribourg 1700 Fribourg KFS Testing the feasibility of an integrated care model in ambulatory oncology furthering RESILience in patients with Gastro-Intestinal and LUNG cancer: a Phase II Trial (GI & LUNG RESIL-Trial) Rüesch Peter, Prof. Dr. Fachstelle Gesundheitswissenschaften Departement Gesundheit Zürcher Hochschule für Angewandte Wissenschaften (ZHAW) 8401 Winterthur KFS Prostate cancer e-health-tutorial (PROCET): development and scientific evaluation Senn Beate, Prof. Dr. Institut für Angewandte Pflegewissenschaft Hochschule für Angewandte Wissenschaften 9001 St. Gallen KFS The impact of the self-management intervention "WOMAN-PRO II programme" on patients with vulvar neoplasia to minimize post-surgical symptom prevalence: a mixedmethods project Urech Corinne, Dr. phil. Frauenklinik Universitätsspital Basel KFS Web-based stress management for newly diagnosed cancer patients (STREAM-1): a randomized, wait-list controlled intervention study

12 Epidemiologische Forschung / Recherche épidémiologique Levi Fabio, Prof. Dr med. Unité d'épidémiologie du cancer Institut universitaire de médecine social et préventive Lausanne (IUMSP) 1010 Lausanne KFS Cancer mortality in Europe: monitoring trends and predictions Low Nicola, Prof. Dr. med. Institut für Sozial- und Präventivmedizin (ISPM) Universität Bern 3012 Bern KFS Human papillomavirus-associated cervical neoplasia in Switzerland at the start of a national vaccination programme: crosssectional study Schneider Uwe, Prof. Radiotherapie Universität Zürich-Vetsuisse Klinik Hirslanden 5000 Aarau KFS The impact of image guided radiotherapy on second cancer incidence Schoeni-Affolter Franziska, Dr. Centre de coordination et de données Etude Suisse de Cohorte VIH 1011 Lausanne KFS An update of cancer risk in persons infected with HIV in Switzerland

13 Stipendien 2013 Bourses 2013 Unterstützt von: / Soutenus par: Bonalli Mario, Dr. med. vet. Anatomisches Institut Universität Zürich 8057 Zürich MD-PhD SAMW MD-PhD Stipendium Isolation and characterization of novel transcription factors involved in neural crest stem cell maintenance and melanoma formation Destination: Anatomisches Institut, Universität Zürich, Zürich Bührer Elias, Dr. med. Universitätsklinik für Medizinische Onkologie Inselspital, Universität Bern MD-PhD SAMW MD-PhD Stipendium The role of CD27 signalling in acute myeloid leukaemia Destination: Universitätsklinik für Medizinische Onkologie, Inselspital, Universitätsspital Bern Dawson Heather, Dr. med. Institut für Pathologie Universität Bern BIL KFS Interaction between EMT-like cancer cells («tumour buds») and blood/lymphatic vessel invasion in the tumour microenvironment of colorectal cancer Destination: Faculty of Medicine, University of Toronto, Toronto, CAN Jauch Annaïse, Dr. med. Departement Biomedizin Universität Basel MD-PhD SAMW MD-PhD Stipendium The role of TSLP mediated inflammation in melanoma development and progression Destination: ISREC, EPF de Lausanne, Lausanne

14 Pauli Chantal, Dr. med. Institut für Klinische Pathologie BIL KFS Genetics and epigenetics of high-grade myxofibrosarcoma: a next generation approach towards a better understanding of sarcomas with complex karyotypes Destination: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA Schaffar Robin, MPH Registre genevois des tumeurs Université de Genève 1205 Genève BIL KFS Long-term net survival among women with breast cancer in Geneva Destination: Department of Non- Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Cancer Research UK, London, GB Waeber Sabine, Dr. med. Faculté de biologie et de médecine Université de Lausanne 1011 Lausanne MD-PhD SAMW MD-PhD Stipendium The role of inflammation in cancer progression: contribution of myeloid-derived suppressor cells (MDSC) and the pro inflammatory cytokines IL-1β and IL-18 Destination: Institut universitaire de pathologie, Centre hospitalier universitaire vaudois (CHUV), Lausanne