Completion Date MM/YYYY University of Richmond, Richmond, VA B.S. 05/1993 Psychology

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1 NAME: Graham, Amanda Louise OMB No /0002 (Rev. 08/12 Approved Through 8/31/2015) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. era COMMONS USER NAME: ALGRAHAM POSITION TITLE: Director, Research Development EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE Completion Date MM/YYYY University of Richmond, Richmond, VA B.S. 05/1993 Psychology FIELD OF STUDY The Chicago Medical School, North Chicago, IL M.S. 05/1995 Clinical Psychology The Chicago Medical School, North Chicago, IL Ph.D. 05/1999 Clinical Psychology VA Connecticut Healthcare System / Yale University Predoctoral 08/1999 Health Psychology Brown Medical School, Providence, RI Postdoctoral 2000 Behavioral Medicine A. PERSONAL STATEMENT My research focuses on 1) developing, evaluating, and optimizing technology-based smoking cessation interventions that have broad reach to smokers who might not otherwise access treatment, and 2) addressing the unique measurement and methodological challenges in conducting technology-based dissemination and implementation research. I have led and collaborated on a range of smoking cessation trials, with a primary focus on web-, telephone, and online social network interventions. I have extensive experience in the management and oversight of web-based randomized trials, including issues unique to the conduct of Internetand social network based studies such as recruitment and retention, measurement issues unique to online social networks, data safety and monitoring, and human subjects protections. I lead the Schroeder Institute s Software Development Team which has developed and deployed the social media mobile application for young adult smokers and a web-based clinical trials management system that form the foundation for this proposal. Our team has also developed a Facebook smoking cessation app and a dynamic text messaging intervention that operates both as a standalone and adjunct intervention to other treatment modalities. 1. Graham AL, Cobb NK, Papandonatos GD, Moreno JL, Kang H, Tinkelman DG, Bock BC, Niaura RS, Abrams DB. A Randomized Trial of Internet and Telephone Treatment for Smoking Cessation. Arch Intern Med Jan 10;171(1): PMID: Richardson A, Graham AL, Cobb NK, Xiao H, Mushro A, Abrams D, Vallone D. Engagement Promotes Quit Behavior in a Web-based Cessation Intervention. J Med Internet Res 2013;15(1):e14. PMID: Graham AL, Cha S, Papandonatos GD, Cobb NK, Mushro A, Fang Y, Niaura RS, Abrams DB. Improving adherence to web-based cessation programs: a randomized controlled trial study protocol. Trials Feb 17;14(1):48. PMCID: PMC Graham AL, Papandonatos GD, Cobb CO, Cobb NK, Niaura RS, Abrams DB, Tinkelman DG. Internet and Telephone Treatment for Smoking Cessation: Mediators and Moderators of Short-Term Abstinence. Nicotine Tob Res Mar;17(3): PMCID: PMC Graham AL, Papandonatos GD, Erar B, Stanton CA. Use of an Online Smoking Cessation Community Promotes Abstinence: Results of Propensity Score Weighting. Health Psychology. In press.

2 B. POSITIONS AND HONORS Positions and Employment Project Director, Brown Medical School Centers for Behavioral & Preventive Medicine, Providence, RI Staff Psychologist, The Miriam Hospital, Providence, RI Assistant Professor of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Visiting Scientist, Dissemination and Implementation Research, Office of the Director in the Division for Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD Assistant Professor (Adjunct), Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Assistant Professor (Tenure Track), Department of Oncology, Georgetown University Medical Center / Lombardi Comprehensive Cancer Center, Washington, DC Associate Director for Research Development, Schroeder Institute for Tobacco Research and Policy Studies, American Legacy Foundation, Washington, DC Assistant Professor (Adjunct), Department of Oncology, Georgetown University Medical Center / Lombardi Comprehensive Cancer Center, Washington, DC 2010 present Director, Research Development, Schroeder Institute for Tobacco Research and Policy Studies, American Legacy Foundation, Washington, DC 2010 present Associate Professor (Adjunct), Department of Oncology, Georgetown University Medical Center / Lombardi Comprehensive Cancer Center, Washington, DC Other Experience and Professional Memberships 1993 Member, American Psychological Association (APA; Division 38, Health Psychology) 1994 Member, Society of Behavioral Medicine (SBM) Chairperson, Measurement and Best Practices Committee, Worksite Wellness Council of Rhode Island Member, President s Council of Emerging Leaders, University of Richmond Member, American Public Health Association (APHA) 2002 Member, Society for Research on Nicotine and Tobacco (SRNT) Expert Panel Member, Dialogue on Dissemination Meetings, National Cancer Institute/NIH 2004 Advanced Training Institute in Health Behavior Theory, National Cancer Institute Planning Committee Member, Canada-US Cancer Control Alliance: Research-Practice Partnerships Integrating Science With Service, National Cancer Institute/NIH, National Cancer Institute of Canada 2005 Roundtable Member, Consumer Demand Initiative, National Tobacco Cessation Collaborative (NTCC) 2011 Member, Canadian Cancer Society Research Institute s Social Media Interventions for Tobacco Prevention and Cessation Grants Review Group 2014 Member, Canadian Cancer Society Research Institute s Partner Prevention Research Grant Review Panel 2014 Member, National Science Foundation Smart and Connected Health (SCH) Program Grant Review Group 2015 Member, NIH Special Emphasis Panel/Scientific Review Group 2015/10 ZRG1 RPIA-W (02) S Honors 1998 Outstanding Dissertation Award, American Psychological Association 2002 Awardee, Loan Repayment Program, National Institutes of Health 2005 Distinguished Service Award, Society of Behavioral Medicine 2006 Distinguished Service Award, Society of Behavioral Medicine 2009 Distinguished Service Award, Society of Behavioral Medicine 2009 Special Service Award, Society of Behavioral Medicine 2010 Fellow, Society of Behavioral Medicine

3 C. CONTRIBUTIONS TO SCIENCE Complete List of Published Work in MyBibliography n=descending 1. Treatment outcome and mechanisms research in web-based smoking cessation interventions. For the past 15 years, I have conducted programmatic research in web-based interventions for smoking cessation, with a focus on identifying the mechanisms of effectiveness and leverage points for optimizing their reach and impact. This work began with a Phase I SBIR project to develop a web-based smoking cessation medication adherence system (R43 CA097903; Graham, Proposal Lead/Co-Investigator) and a second Phase I SBIR to develop a web-based system to integrate an Internet intervention with quitline counseling (R43 CA099211; Graham, Proposal Lead/Co-Investigator). Both projects developed core infrastructure and features for one of the largest web-based cessation programs that is currently in operation today. This work also provided the foundation for one of the first randomized controlled trials for web-based cessation (The iquitt Study: R01 CA104836, Graham, PI). Cost effectiveness analyses demonstrated that optimal adherence to Internet interventions yielded the highest number of quitters at the lowest cost, and mechanisms research identified sustained treatment engagement as a key mediator of treatment effectiveness. This body of work represents a substantial part of the field of Internet smoking cessation research. I served as the primary investigator or co-investigator in all of these studies. a. Graham AL, Cobb NK, Papandonatos GD, Moreno JL, Kang H, Tinkelman DG, Bock BC, Niaura RS, Abrams DB. A Randomized Trial of Internet and Telephone Treatment for Smoking Cessation. Arch Intern Med Jan 10;171(1): PMCID: PMC b. Graham AL, Chang Y, Fang Y, Cobb NK, Tinkelman DS, Niaura RS, Abrams DB, Mandelblatt JS. Cost-Effectiveness of Internet and Telephone Treatment for Smoking Cessation: An Economic Evaluation of The iquitt Study. Tob Control Nov;22(6):e11. PMCID: PMC c. Graham AL, Papandonatos GD, Cobb CO, Cobb NK, Niaura RS, Abrams DB, Tinkelman DG. Internet and Telephone Treatment for Smoking Cessation: Mediators and Moderators of Short- Term Abstinence. Nicotine Tob Res Mar;17(3): PMCID: PMC d. Cobb CO, Graham AL. Use of non-assigned interventions in a randomized trial of Internet and telephone treatment for smoking cessation. Nicotine Tob Res Oct;16(10): PMCID: PMC Online social networks in smoking cessation. Web-based cessation programs commonly include social media and Web 2.0 applications to facilitate the creation and sharing of user-generated content among current and former smokers. Research that I have led and collaborated on has demonstrated that participation in online social networks for cessation may be a key driver of abstinence. Early publications documented that individuals who participated in an online cessation community were more likely to be abstinent than those who did not and that there was a dose-response relationship between intensity of community engagement and abstinence. In 2010, I co-led the planning efforts of a 2-day conference titled Online Social Networks and Smoking Cessation: Strategic Research Opportunities that we hosted at the Schroeder Institute for Tobacco Research and Policy Studies. The conference brought together more than 100 experts across a broad range of disciplines with the goal of constructing a strategic research agenda for online social network research. A key outcome of the conference was a call for more rigorous and transdisciplinary research to elucidate the mechanisms through which social networks influence behavior change. This is the focus of a current study (R01 CA192345; Graham/Zhao MPI) which examines the social dynamics of smoking cessation in a 6-year longitudinal dataset from one of the largest online social networks for cessation. I have also collaborated on and now lead research that examines the effectiveness of disseminating an evidence-based cessation intervention through smokers existing social networks in Facebook (R01 CA155369). This study represents a model for conducting dissemination research within an open online social network and demonstrates the potential to drive viral spread of an intervention to achieve population-level impact. a. Cobb NK, Graham AL, Byron MJ, Niaura RS, Abrams DB. Online Social Networks and Smoking Cessation: A Scientific Research Agenda. J Med Internet Res. 2011;13(4):e119. PMID: b. Graham AL, Cha S, Papandonatos GD, Cobb NK, Mushro A, Fang Y, Niaura RS, Abrams DB. Improving adherence to web-based cessation programs: a randomized controlled trial study protocol. Trials Feb 17;14(1):48. PMCID: PMC

4 c. Cobb NK, Jacobs MA, Saul J, Wileyto P, Graham AL. Diffusion of an Evidence-Based Smoking Cessation Intervention Through Facebook: A Randomized Controlled Trial Study Protocol. BMJ Open. 2014;4:e PMCID: PMC d. Graham AL, Cobb CO, Cobb NK. (In Press). The Internet, Social Media, and Health Decision Making. In Diefenbach MA, Miller SM, Bowen D. (Eds.). Handbook of Health Decision Science. New York, NY: Springer Verlag. 3. Measures development for tobacco research. Two key contributions of my work have been the development and validation of measurement instruments for smoking cessation research, and the examination of the psychometric properties of existing measures when administered via the Internet. In addition to the work cited below, my publications in this area include the development of a reliable retrospective measure of lifetime smoking history; and an evaluation of the psychometric properties of a measure of nicotine dependence in a population-based sample of older heavier smoking adults. a. Graham AL, Papandonatos GD, Bock BC, Cobb NK, Baskin-Sommers A, Niaura R, Abrams DB. Internet- vs. telephone-administered questionnaires in a randomized trial of smoking cessation. Nicotine Tob Res Dec;8 Suppl 1:S PMID: b. Graham AL, Papandonatos GD. Reliability of internet- versus telephone-administered questionnaires in a diverse sample of smokers. J Med Internet Res Mar 26;10(1):e8. PMID: c. Hwang KO, Ottenbacher AJ, Lucke JF, Etchegaray JM, Graham AL, Thomas EJ, Bernstam EV. Measuring social support for weight loss in an Internet weight loss community. J Health Commun Feb;16(2): PMID: d. Graham AL, Papandonatos GD, Kang H, Moreno JL, Abrams DB. Development and validation of the Online Social Support for Smokers Scale. J Med Internet Res Sep 28;13(3):e69. PMID: Expanding the reach and systems integration of online cessation interventions. My publications have documented the characteristics and patterns of smokers who search online for cessation treatment; examined the impact of online advertising strategies in recruiting smokers to an online cessation intervention and their cost effectiveness; addressed the noted challenge in recruiting Latino smokers to Internet cessation interventions and documented a novel research paradigm for developing culturally targeted advertising; and highlighted the methodological challenges in evaluating the reach of web-based interventions. Other publications have described opportunities to improve cancer prevention and control by integrating scalable and sustainable technology-based tobacco treatment interventions into primary care clinics, worksites, and pharmacies. a. Graham AL, Cobb NK, Raymond L, Sill S, Young J. Improving The Reach Of Worksite Smoking Cessation Programs. Health Educ Behav. 2006;33(2): b. Graham AL, Bock BC, Cobb NK, Niaura R, Abrams DB. Characteristics of Smokers Reached and Recruited to an Internet Smoking Cessation Trial: A Case of Denominators. Nicotine Tob Res Dec; 8 Suppl 1:S PMID: c. Graham AL, Milner P, Saul JE, Pfaff L. Online advertising as a public health and recruitment tool: comparison of different media campaigns to increase demand for smoking cessation interventions. J Med Internet Res Dec 15;10(5):e50. PMID: d. Graham AL, Fang Y, Moreno JL, Streiff SL, Villegas J, Muñoz RF, Tercyak KP, Mandelblatt JS, Vallone DM. Impact and Costs of Online Advertising to Reach and Recruit Latino Smokers to an Internet Cessation Program. J Med Internet Res 2012;14(4):e116. doi: /jmir PMID: D. RESEARCH SUPPORT Ongoing Research Support R01 DA A1 Graham (PI) 04/01/ /31/2020 NIH/NIDA Optimizing Text Messaging to Improve Adherence to Web-Based Cessation Treatment Examines the effectiveness of dynamic, tailored text messaging in improving adherence to a web-based smoking cessation program.

5 R01 CA Graham/Zhao (MPI) 09/01/ /31/2017 Social Dynamics of Substance Use in Online Social Networks for Smoking Cessation Examines how online social networks influence smoking cessation. Using modern and innovative social computing methods, we will examine social network dynamics, sentiment, and social support in a 6-year longitudinal online social network for smoking cessation. /Project Leader R01 CA Graham (PI) 07/01/ /30/2016 Improving Adherence to Web-Based Cessation Programs: A Social Network Approach Evaluates the effectiveness of a social network intervention to improve behavioral and pharmacological smoking cessation treatment adherence and cessation outcomes. R01 CA Shuter/Stanton (MPI) 07/01/ /30/2020 NIH through Albert Einstein College of Medicine RCT of An Internet Cessation Program Plus Online Social Network for HIV + Smokers Evaluates the comparative effectiveness of a web-based smoking cessation program for HIV+ smokers alone and in conjunction with an online social network against usual care. Role: Subaward PI R01 CA A1 O Neill (PI) 07/01/ /30/2019 NIH through Georgetown University Applying Breast Density to Risk Counseling Examines the effectiveness of an individually tailored interactive risk communication and decision support intervention on uptake of chemoprevention. Role: Subaward PI R21 CA C. Cobb (PI) 04/01/ /31/2016 Behavior and toxicant exposure among dual users of cigarettes and e-cigarettes This clinical laboratory study examines how e-cigarette use affects measures of tobacco product consumption and toxicant exposure among current cigarette smokers. Role: Co-Investigator Pfizer Medical Education Group # Iguchi/Tercyak (MPI) 12/15/ /14/2015 Bringing EX to A Million Hearts This study evaluates the impact of primary care provider assessment, advice, and referral to an online smoking cessation resource within primary care clinics participating in the national Million Hearts Initiative. Role: Co-Investigator/Site PI FDA BAA /24/ /23/2015 FDA through Epidemico Enhancing tobacco surveillance through online monitoring Assist Epidemico in reviewing and staying current on research on social media and tobacco; inform the project on methods for behavior modification for tobacco use using Internet technologies. Role: Consultant Completed Research Support R01 CA A1 Graham (PI) 07/01/ /30/2015 NIH/NCI Online Social Networks for Smoking Cessation Intervention Dissemination This study is a randomized trial of the diffusion of an evidence-based software application for smoking cessation embedded within the Facebook social network. (grant transferred from Dr. Nathan Cobb) R13 HL Graham (PI) 04/01/ /31/2013 Society of Behavioral Medicine 2012 Annual Meeting and Scientific Sessions This award supported the Society of Behavioral Medicine's 2012 Annual Meeting and Scientific Sessions which brought together leading behavioral and social scientists, clinicians, and policymakers to exchange the latest findings from population- and clinic-based research on the causes, prevention, and clinical care of cardiovascular, lung, and blood diseases and sleep disorders.