Cardiopatie Aritmogene nel Giovane
|
|
|
- Kerry Owens
- 8 years ago
- Views:
Transcription
1 Firenze, 16 Novembre 2012 Cardiopatie Aritmogene nel Giovane Prof. Luigi Padeletti Università degli Studi di Firenze
2 1) Long QT Syndrome 2) Short QT Syndrome 3) J wave Syndrome: Early Repolarization Syndrome Brugada Syndrome Curr Probl Cardiol 2012;37:
3 Long QT Syndrome Long QT syndrome (LQTS) is a hereditary repolarization disorder characterized by a prolonged QT interval on surface ECG, syncope, polymorphic VT, and increased risk of sudden cardiac arrest in individuals with no underlying structural heart disease. Curr Probl Cardiol 2012;37:
4 Come calcolare correttamente il QT Johnson JN & Ackerman NJ, Br J Sports Med 2009
5 Possibili varianti morfologiche dell onda T Goldenberg, Moss & Zareba, J Cardiovasc Electrophysiol 2006
6 Dal QT al QTc Goldenberg, Moss & Zareba, J Cardiovasc Electrophysiol 2006
7 Zareba W, Progress in Cardiovascular Diseases 2008
8 Sovrapposizione fra soggetti sani e pazienti affetti da LQTS Johnson JN & Ackerman NJ, Br J Sports Med 2009
9 Diagnosi di Long QT Syndrome Schwartz Score 1) Criteri Elettrocardiografici 2) Anamnesi personale 3) Anamnesi famigliare LQTS Probality Score 1 poin or less = low probability 2 to 3 points = intermediate probability 4 points or higher = hight probability Zareba W, Progress in Cardiovascular Diseases 2008
10 Long QT Syndrome Zareba W, Progress in Cardiovascular Diseases 2008
11 Fisiopatologia
12 Fisiopatologia Zareba W, Progress in Cardiovascular Diseases 2008
13 Forme più frequenti di LQTS Roden DM et al, NEJM 2008
14 LQT3 LQT2 LQT1 Zareba W, Progress in Cardiovascular Diseases 2008
15 Triggers Zareba W, Progress in Cardiovascular Diseases 2008
16 Stratificazione del Rischio By Gender Goldenberg et at. JACC Vol. 51, No. 24, 2008
17 Stratificazione del Rischio By QTc duration Zareba W, Progress in Cardiovascular Diseases 2008
18 Stratificazione del Rischio By Syncope Goldenberg et at. JACC Vol. 51, No. 24, 2008
19 Stratificazione del Rischio By LQTS genotypes It has been suggested that arrhythmic risk is related to the presence of specific LQTS genotypes. The lethality of cardiac events was found to be significantly higher in LQT3 than in LQT2 and LQT1 family members Goldenberg et at. JACC Vol. 51, No. 24, 2008
20 Stratificazione del Rischio Goldenberg and Moss, JACC 2008
21 Indicazioni terapeutiche Roden DM et al, NEJM 2008
22 Zareba W, Progress in Cardiovascular Diseases 2008
23 Effetto della denervazione autonomica cardiaca Zareba Progress in Cardiovascular Disease 2008
24 Genetic Testing 1) Genetic testing can identify a mutation in 50 to 75% of probands in whom the diagnosis appears to be certain on clinical grounds. 2) A negative genetic test does not rule out the diagnosis. 3) There is also the potential for false positive results, since detection of a mutation does not establish the diagnosis. 4) Genetic testing is most useful in two settings: When a clinical diagnosis is relatively certain, knowing the specific gene affected may clarify the prognosis In a family with an affected proband and a known genetic defect, the genotyping of family members can help rule out the diagnosis in some patients. However a positive test identifies a family member as being a mutation carrier, even if he or she is asymptomatic and has a normal QT interval. Roden DM et al, NEJM 2008
25 Short QT Syndrome The hereditary short QT syndrome (SQTS) is a recently described repolarization disorder associated with sudden cardiac death in individuals with no underlying structural heart disease. Curr Probl Cardiol 2012;37:
26 Short QT Syndrome Twelve-lead electrocardiogram of a patient with short QT syndrome Curr Probl Cardiol 2012;37:
27 Short QT Syndrome Point-scoring system for diagnosis of SQTS Patients are classified as 1. low probability (score 2) 2. intermediate probability (3 points) 3. high probability (4 points) of short QT syndrome. Curr Probl Cardiol 2012;37:
28 Short QT Syndrome Therapy Options 1) ICD implant. 2) Use of hydroquinidine to suppress recurrent VT/VF and also in patients deemed unsuitable for or who refuse an ICD implant. 3) Use of amiodarone in suppressing recurrent VT in a patient has been reported.there are no long-term data on the use of amiodarone in patients with SQTS. Curr Probl Cardiol 2012;37:
29 Early Repolarization Pattern The Early History J wave Antzelevitch et al. Heart Rhythm 2010
30 Early Repolarization Variants (ERPV) Boineau et al. Journal of Electrocardiology 2007
31 Early Repolarization Pattern Pathophysiology Antzelevitch et al. Heart Rhythm 2010
32 Pattern di ER a sede inferiore o laterale Haïssaguerre M et al, NEJM 2008
33 The History Antzelevitch et al. Heart Rhythm 2010
34 Variazioni temporali del punto J ed eventi aritmici Haïssaguerre M et al, NEJM 2008
35 Modalità di insorgenza di FV Relazione con la frequenza cardiaca Soppressione degli eventi di FV dopo aumento della frequenza di pacing atriale Nam GB et al, Eur Heart J 2010
36 Modalità di insorgenza di FV Relazione con la frequenza cardiaca Soppressione degli eventi di FV somministrazione di Isoproterenolo Nam GB et al, Eur Heart J 2010
37 Is the Early Repolarization Pattern a benign ECG manifestation?
38 Sudden Cardiac Arrest Associated with Early Repolarization HR 2.1 ( P=0.008) 206 pazienti rianimati dopo FV idiopatica ER inferiore/laterale 64 (31%) Haïssaguerre M et al, NEJM 2008
39 Long-Term Outcome Associated with Early Repolarization on Electrocardiography Tikkanen JT et al, NEJM 2009
40 Long-Term Outcome Associated with Early Repolarization on Electrocardiography Unadjusted RR 3.52 ( ) Unadjusted RR 3.94 ( ) Tikkanen JT et al, NEJM 2009
41 Differenti morfologie del tratto ST in pazienti con ER a sede inferiore ER con ST ascendente ER con ST orizzontale/discendente Tikkanen JT et al, Circulation 2011
42 Pattern di ER & SCD Solamente il quadro di ER a sede inferiore con ST orizzontale/discendente è risultato associato ad eventi aritmici fatali nella popolazione di soggetti (52% maschi, età media 44 ± 8.5 anni) già studiata precedentemente (NEJM 2009) Tikkanen JT et al, Circulation 2011
43 popolazione generale ER a sede inferiore Uberoi A et al, Circulation 2011
44 29281 ECGs alla VA Palo Alto Health Care System 87% maschi 55 ± 14 anni ER 2.3% F-U mediano 7.6 anni 1995 morti cardiache Uberoi A et al, Circulation 2011
45 Uberoi A et al, Circulation 2011
46 J wave Syndromes Antzelevitch et al. Heart Rhythm 2010
47 Brugada Syndrome The Early History Antzelevitch et al. Heart Rhythm 2010
48
49 Current Electrocardiographic Criteria for diagnosis of Brugada Pattern: a Consensus Report Type I Type II Bayés de Luna et al. Journal of Electrocardiology 45 (2012)
50 Current Electrocardiographic Criteria for diagnosis of Brugada Pattern: a consensus report Bayés de Luna et al. Journal of Electrocardiology 45 (2012)
51 From Brugada Pattern to Brugada Syndrome Brugada Syndrome is definitively diagnosed only if the ECG displays type 1 pattern in more than 1 precordial lead (V1-V3), either spontaneously or provoked after administration of a sodium channel blocking agent and is associated with 1 or more of the following clinical characteristics: 1. Syncope 2. Nocturnal agonal respiration 3. Inducible VT/VF with electrical stimulation 4. Family history of sudden cardiac death 45 years 5. Type 1 ECG pattern in family member 6. Spontaneous VT/VF Curr Probl Cardiol 2012;37:
52 Età di comparsa di episodi spontanei di FV/SD Benito B. et al., Progress in Cardiovasc Disease 2008
53 Pattern circadiano di FV nella Sindrome di Brugada Matsuo et al. Eur Heart J 1999
54 Management of patients with Brugada Syndrome: Results of the PRELUDE Registry Survival According to VTs/VF Inducibility Priori S et al.j Am Coll Cardiol 2012;59:37 45
55 Management of patients with Brugada Syndrome: Results of the PRELUDE Registry Survival According to History of Syncope Priori S et al.j Am Coll Cardiol 2012;59:37 45
56 Management of patients with Brugada Syndrome: Results of the PRELUDE Registry Survival According to Presence of Spontaneous type 1 ECG Priori S et al.j Am Coll Cardiol 2012;59:37 45
57 Management of patients with Brugada Syndrome: Results of the PRELUDE Registry Survival According to Presence of Ventricular Refractory < 200 ms Priori S et al.j Am Coll Cardiol 2012;59:37 45
58 Management of patients with Brugada Syndrome: Results of the PRELUDE Registry Survival According to Presence of QRS fragmentation Priori S et al.j Am Coll Cardiol 2012;59:37 45
59 CONCLUSION: Our data show that VT/VF inducibility is unable to identify high-risk patients, whereas the presence of a spontaneous type I ECG, history of syncope, ventricular effective refractory period 200 ms, and QRS fragmentation seem useful to identify candidates for prophylactic implantable cardioverter defibrillator. Priori S et al.j Am Coll Cardiol 2012;59:37 45
Diagnostic Scoring System for LQTS
Medical Coverage Policy Genetic Testing: Congenital Long QT Syndrome Device/Equipment Drug Medical Surgery Test Other Effective Date: 2/15/2011 Policy Last Updated: 2/21/2012 Prospective review is recommended/required.
Long QT. Long QT Syndrome. A Guide for
Long QT Long QT Syndrome A Guide for Introduction Long QT syndrome (LQTS) is a genetic heart disorder due to the malfunction of cardiac ion channels that results in 4,000 deaths annually in the United
Long QT syndrome! Should we treat all asymptomatic patients?!
! Long QT syndrome! Should we treat all asymptomatic patients?! Venice Arrhythmia 2015! Arthur A.M. Wilde Heart Centre NO CONFLICT OF INTEREST TO DECLARE Long QT Syndrome(s) Autosomal dominant/autosomal
Life Threatening EKG s In The Office. Joseph A Manfredi, MD, FACC, FHRS GHS Cardiovascular Symposium
Life Threatening EKG s In The Office Joseph A Manfredi, MD, FACC, FHRS GHS Cardiovascular Symposium January 24 th, 2015 Disclosures Speaker Honorariums: STJM, Boston Scientific Advisory role: Medtronic
Corporate Medical Policy
Corporate Medical Policy Genetic Testing for Cardiac Ion Channelopathies File Name: Origination: Last CAP Review: Next CAP Review: Last Review: genetic_testing_for_cardiac_ion_channelopathies 10/2008 4/2015
January 14-15, 2011 SCA Conference 2
Electrical Abnormalities: Long QT and Beyond Yaniv Bar-Cohen, M.D. Assistant Professor of Pediatrics Division of Cardiology / Electrophysiology Childrens Hospital Los Angeles Keck School of Medicine Genetic
Electrocardiographic Issues in Williams Syndrome
Electrocardiographic Issues in Williams Syndrome R. Thomas Collins II, MD Assistant Professor, Pediatrics and Internal Medicine University of Arkansas for Medical Sciences Arkansas Children s Hospital
Medical Policy Manual. Topic: Genetic Testing for Cardiac Ion Channelopathies Date of Origin: December 2012
Medical Policy Manual Topic: Genetic Testing for Cardiac Ion Channelopathies Date of Origin: December 2012 Section: Genetic Testing Last Reviewed Date: December 2015 Policy No: 07 Effective Date: January
How to read the ECG in athletes: distinguishing normal form abnormal
How to read the ECG in athletes: distinguishing normal form abnormal Antonio Pelliccia, MD Institute of Sport Medicine and Science www.antoniopelliccia.it Cardiac adaptations to Rowing Vagotonia Sinus
Guidelines for the diagnosis and management of Brugada Syndrome
The Cardiac Society of Australia and New Zealand Guidelines for the diagnosis and management of Brugada Syndrome Development of these guidelines was co-ordinated ordinated by A/Prof Jitendra Vohra and
Genetic Long QT Syndrome GENETIC TESTING FOR LONG QT SYNDROME HS-148. Policy Number: HS-148. Original Effective Date: 1/21/2010
Harmony Behavioral Health, Inc. Harmony Behavioral Health of Florida, Inc. Harmony Health Plan of Illinois, Inc. HealthEase of Florida, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance
Overview of Inherited Heart Rhythm Disorders for Patients
Introduction Overview of Inherited Heart Rhythm Disorders for Patients Inherited heart rhythm disorders affect a small portion of the population, presenting as palpitations, fainting, heart arrest and
Natural History of Early Repolarization in the Inferior Leads
ORIGINAL ARTICLE Natural History of Early Repolarization in the Inferior Leads Ricardo Stein, M.D., Karim Sallam, M.D., Chandana Adhikarla, M.D., Madhavi Boga, M.D., Alexander D. Wood, B.Sc., and Victor
A Case of Long QT Syndrome Type 3 Aggravated by Beta-Blockers and Alleviated by Mexiletine: The Role of Epinephrine Provocation Test
Case Report http://dx.doi.org/10.3349/ymj.2013.54.2.529 pissn: 0513-5796, eissn: 1976-2437 Yonsei Med J 54(2):529-533, 2013 A Case of Long QT Syndrome Type 3 Aggravated by Beta-Blockers and Alleviated
The QT interval: Too long, too short or just right
CONTEMPORARY REVIEW The QT interval: Too long, too short or just right Sami Viskin, MD From Tel-Aviv Sourasky Medical Center, Sackler-School of Medicine, Tel Aviv, Israel. The hallmark of the congenital
Long QT Syndrome Genetic Testing for Inherited Arrhythmias. patient guide
Long QT Syndrome Genetic Testing for Inherited Arrhythmias patient guide What is Long QT Syndrome? Arrhythmias are problems with the electrical system in the heart that controls the heartbeat s regular
Usefulness of Epinephrine Test in the Congenital Long QT Syndrome
Usefulness of Epinephrine Test in the Congenital Long QT Syndrome Wataru Shimizu M.D., Ph.D. CASE PRESENTATION A 14-year old Japanese boy was successfully resuscitated from cardiac arrest (near drowning)
How do you decide on rate versus rhythm control?
How do you decide on rate versus rhythm control? Dr. Mark O Neill Consultant Cardiologist & Electrophysiologist Assumptions Camm et al. EHJ 2010;Sept 25 epub Choice of strategy: Criteria for consideration
European Heart Journal (2001) 22, 2290 2296 doi:10.1053/euhj.2001.2691, available online at http://www.idealibrary.com on
European Heart Journal (00), 90 96 doi:0.053/euhj.00.69, available online at http://www.idealibrary.com on New electrocardiographic leads and the procainamide test for the detection of the in sudden unexplained
Role of implantable cardioverter defibrillator therapy in patients with long QT syndrome
Role of implantable cardioverter defibrillator therapy in patients with long QT syndrome James P. Daubert, MD, Wojciech Zareba, MD, PhD, Spencer Z. Rosero, MD, Adam Budzikowski, MD, PhD, Jennifer L. Robinson,
Congenital long QT syndrome: Considerations for primary care physicians
REVIEW CME CREDIT ETHAN LEVINE, DO Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY ARTHUR J. MOSS, MD Cardiology Division, Department of Medicine, University
Assessment, diagnosis and specialist referral of adults (>16 years) with an episode of transient loss of consciousness (TLoC) or a blackout.
Assessment, diagnosis and specialist referral of adults (>16 years) with an episode of transient loss of consciousness (TLoC) or a blackout. TLoC is common huge variation in management range of clinicians
Long-QT Syndrome. The Cl inic a l Problem
T h e n e w e ng l a nd j o u r na l o f m e dic i n e clinical practice Long-QT Syndrome Dan M. Roden, M.D. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence
ARTICLE IN PRESS. Available online at www.sciencedirect.com. Received 5 November 2008
Available online at www.sciencedirect.com Journal of Electrocardiology xx (2009) xxx xxx www.jecgonline.com Exploring QT interval changes as a precursor to the onset of ventricular fibrillation/tachycardia
LQTS: Long QT Syndrome. Inherited Heart Disease Clinic
2011 LQTS: Long QT Syndrome Inherited Heart Disease Clinic What is LQTS? LQTS is a rare heart rhythm disorder. It causes a disruption of the electrical signal that stimulates your heart to beat. It occurs
Electrocardiography Review and the Normal EKG Response to Exercise
Electrocardiography Review and the Normal EKG Response to Exercise Cardiac Anatomy Electrical Pathways in the Heart Which valves are the a-v valves? Closure of the a-v valves is associated with which heart
Previously Published Works UC San Francisco
Previously Published Works UC San Francisco A University of California author or department has made this article openly available. Thanks to the Academic Senate s Open Access Policy, a great many UC-authored
LAST NAME VAT NUMBER. PHONE (Important for possible case discussion)
Long QT Panel CUSTOMER INFORMATION FIRST NAME LAST NAME ORGANIZATION VAT NUMBER BILLING ADDRESS 1ST LINE BILLING ADDRESS 2ND LINE POST CODE CITY COUNTRY EMAIL (Required) PHONE (Important for possible case
Sudden Arrhythmia Death Syndrome: Importance of the Long QT Syndrome
Sudden Arrhythmia Death Syndrome: Importance of the Long QT Syndrome JOHN S. MEYER, M.D., St. Luke s Hospital, Chesterfield, Missouri ALI MEHDIRAD, M.D., Midwest Heart Rhythm, St. Louis, Missouri BAKR
ATRIAL FIBRILLATION (RATE VS RHYTHM CONTROL)
ATRIAL FIBRILLATION (RATE VS RHYTHM CONTROL) By Prof. Dr. Helmy A. Bakr Mansoura Universirty 2014 AF Classification: Mechanisms of AF : Selected Risk Factors and Biomarkers for AF: WHY AF? 1. Atrial fibrillation
Guidelines for the diagnosis and management of Familial Long QT Syndrome
The Cardiac Society of Australia and New Zealand Guidelines for the diagnosis and management of Familial Long QT Syndrome These guidelines were revised by Dr Jonathan Skinner and a members of the Cardiovascular
How should we treat atrial fibrillation in heart failure
Advances in Cardiac Arrhhythmias and Great Innovations in Cardiology Torino, 23/24 Ottobre 2015 How should we treat atrial fibrillation in heart failure Matteo Anselmino Dipartimento Scienze Mediche Città
Rome, Italy December 4-7, 2012 Rome Cavalieri TIMETABLE
Rome, Italy December 4-7, 2012 Rome Cavalieri Monday, December 3 ROOM Terrazza Monte Mario PATIENT MANAGEMENT CONCEPTS AND CONTROVERSIES IN ELECTROPHYSIOLOGY BIOTRONIK International Fellows Program (IFP)
NEONATAL & PEDIATRIC ECG BASICS RHYTHM INTERPRETATION
NEONATAL & PEDIATRIC ECG BASICS & RHYTHM INTERPRETATION VIKAS KOHLI MD FAAP FACC SENIOR CONSULATANT PEDIATRIC CARDIOLOGY APOLLO HOSPITAL MOB: 9891362233 ECG FAX LINE: 011-26941746 THE BASICS: GRAPH PAPER
Potential Causes of Sudden Cardiac Arrest in Children
Potential Causes of Sudden Cardiac Arrest in Children Project S.A.V.E. When sudden death occurs in children, adolescents and younger adults, heart abnormalities are likely causes. These conditions are
Risk Stratification in the Long-QT Syndrome
The new england journal of medicine original article Risk Stratification in the Long-QT Syndrome Silvia G. Priori, M.D., Ph.D., Peter J. Schwartz, M.D., Carlo Napolitano, M.D., Ph.D., Raffaella Bloise,
Introduction to Electrophysiology. Wm. W. Barrington, MD, FACC University of Pittsburgh Medical Center
Introduction to Electrophysiology Wm. W. Barrington, MD, FACC University of Pittsburgh Medical Center Objectives Indications for EP Study How do we do the study Normal recordings Abnormal Recordings Limitations
Acquired, Drug-Induced Long QT Syndrome
Acquired, Drug-Induced Long QT Syndrome A Guide for Patients and Health Care Providers Sudden Arrhythmia Death Syndromes (SADS) Foundation 508 E. South Temple, Suite 202 Salt Lake City, Utah 84102 800-STOP
Københavns Universitet
university of copenhagen Københavns Universitet Automatic J-point Location in Subjects with Electrocardiographic Early Repolarization Melgaard, Jacob; Struijk, Johannes J.; Hansen, John; Kanters, Jørgen
Automatic External Defibrillators
Last Review Date: May 27, 2016 Number: MG.MM.DM.10dC2 Medical Guideline Disclaimer Property of EmblemHealth. All rights reserved. The treating physician or primary care provider must submit to EmblemHealth
Atrial Fibrillation: Drugs, Ablation, or Benign Neglect. Robert Kennedy, MD October 10, 2015
Atrial Fibrillation: Drugs, Ablation, or Benign Neglect Robert Kennedy, MD October 10, 2015 Definitions 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary.
National Medical Policy
National Medical Policy Subject: Policy Number: Genetic Testing for Long QT Syndrome NMP490 Effective Date*: February 2005 Updated: August 2015 This National Medical Policy is subject to the terms in the
EXPERIMENTAL AND THERAPEUTIC MEDICINE 8: 201-206, 2014
EXPERIMENTAL AND THERAPEUTIC MEDICINE 8: 201-206, 2014 Feasibility and efficacy of a remote real time wireless ECG monitoring and stimulation system for management of ventricular arrhythmia in rabbits
HIV, High Dose Methadone, and the Treatment Conundrum 5/8/2014. Frederick L. Altice, MD, MA
EXPERT PANEL Managing HIV in Special Circumstances: Patients on High-Dose Methadone Frederick L. Altice, MD, MA Professor of Medicine, Epidemiology, and Public Health Yale University HIV, High Dose Methadone,
How to control atrial fibrillation in 2013 The ideal patient for a rate control strategy
How to control atrial fibrillation in 2013 The ideal patient for a rate control strategy L. Pison, MD Advances in Cardiac Arrhythmias and Great Innovations in Cardiology - Torino, September 28 th 2013
Investigation of Ion Channel Gene Variants in Patients with Long QT Syndrome
Investigation of Ion Channel Gene Variants in Patients with Long QT Syndrome Ernesto Curty 1, Fernando Eugênio dos Santos Cruz 2, Fabiane Santos Lima 1, Jorge Luiz Albuquerque Coutinho 2, Rosane Silva
Genetics for preventative cardiology. Objectives HEART DISEASE COMES IN MANY FORMS!
Genetics for preventative cardiology Robert Nussbaum, MD Chief of Genomic Medicine, UCSF Medical Center; Co-Director, Program in Cardiovascular Genetics, UCSF Heart and Vascular Center Julianne Wojciak,
sudden cardiac death, torsades de pointes, T wave alternans, syncope, genetic mutation
Reprinted with permission from JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY Volume 12 No. 4 April 2001 Copyright 2001 by Futura Publishing Company Inc. Armonk NY 10504-0418 Electrocardiographic Prediction
Innovation Platform: Sudden Cardiac Death
Innovation Platform: Sudden Cardiac Death Prof. dr. Bart Loeys CRC Antwerp General Assembly VzW Board of Directors Strategic Advisory Board Staff: 1 executive director 1 ICT manager 1 financial administration
www.irishheart.ie LONG QT SYNDROME SUPPORT GROUP IRELAND
www.irishheart.ie LONG QT SYNDROME SUPPORT GROUP IRELAND Long QT Syndrome Support Group This is a voluntary group of people, all of whom have families with Long QT syndrome (LQTS). It was set up in association
QT analysis: A guide for statistical programmers. Prabhakar Munkampalli Statistical Analyst II Hyderabad, 7 th September 2012
QT analysis: A guide for statistical programmers Prabhakar Munkampalli Statistical Analyst II Hyderabad, 7 th September 2012 Agenda ECG ICH E14 Thorough QT/QTc study Role of Statistical Programmer References
Appropriate Use Criteria for ICD/CRT Online Appendix Guideline Mapping and References Document
Appropriate Use Criteria for ICD/CRT Online Appendix Guideline Mapping and References Document Section 1: Secondary Prevention Table 1.1 CAD: VF or Hemodynamically Unstable VT Associated With Acute (
Genetic Testing for Long QT Syndrome
Technology Evaluation Center Genetic Testing for Long QT Syndrome Assessment Program Volume 22, No. 9 February 2008 Executive Summary Background A genetic test is currently commercially available for mutations
Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population. Carel Jan Willem Borleffs
Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population Carel Jan Willem Borleffs The studies described in this thesis were performed at the Department
Provocative testing with epinephrine infusion has become
Epinephrine Infusion in the Evaluation of Unexplained Cardiac Arrest and Familial Sudden Death From the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry Andrew D. Krahn, MD; Jeffrey S.
Clinical Policy Title: Genetic Testing for Long QT Syndrome (LQTS)
Clinical Policy Title: Genetic Testing for Long QT Syndrome (LQTS) Clinical Policy Number: (391) 04.01.02 Effective Date: Dec. 1, 2013 Initial Review Date: June 19, 2013 Most Recent Review Date: July 17,
Atrial Fibrillation and Cardiac Device Therapy RAKESH LATCHAMSETTY, MD DIVISION OF ELECTROPHYSIOLOGY UNIVERSITY OF MICHIGAN HOSPITAL ANN ARBOR, MI
Atrial Fibrillation and Cardiac Device Therapy RAKESH LATCHAMSETTY, MD DIVISION OF ELECTROPHYSIOLOGY UNIVERSITY OF MICHIGAN HOSPITAL ANN ARBOR, MI Outline Atrial Fibrillation What is it? What are the associated
Il loop recorder esterno. Roberto Maggi
Il loop recorder esterno Roberto Maggi ECG monitoring and syncope In-hospital monitoring Holter Monitoring Event recorder External loop recorder Remote (at home) telemetry Implantable loop recorder External
Non-Invasive Risk Predictors in (Children with) Pulmonary Hypertension
Ideal risk prognosticator Easy to acquire Non-Invasive Risk Predictors in (Children with) Pulmonary Hypertension Safe -- Non-invasive Robust Gerhard-Paul Diller Astrid Lammers Division of Adult Congenital
L ong QT syndrome causes sudden
LEADING ARTICLE 445 Cardiology... Is there a relation between SIDS and long QT syndrome? J R Skinner... A discussion of the evidence to date L ong QT syndrome causes sudden unexpected death through rapid
Pharmacology & Therapeutics
Pharmacology & Therapeutics 131 (2011) 171 177 Contents lists available at ScienceDirect Pharmacology & Therapeutics journal homepage: www.elsevier.com/locate/pharmthera Associate Editor: O. Binah Pharmacological
Danish Cardiovascular Research Academy and Faculty of Health Sciences University of Copenhagen
Danish Cardiovascular Research Academy and Faculty of Health Sciences University of Copenhagen PhD course: Cardiac arrhythmias - Aim and content: Cardiac arrhythmia represents a wide spectrum of abnormalities
Polymorphisms in the NOS1AP Gene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome
Journal of the American College of Cardiology Vol. 55, No. 24, 2010 2010 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2009.12.065
New Study Questions Sports Restrictions for Children with Long QT Syndrome
(http://consultqd.clevelandclinic.org) RESEARCH Apr. 22, 2015 @ 9:31 a.m. New Study Questions Sports Restrictions for Children with Long QT Syndrome A wider range of activities may be safe Conventional
La facilitazione alla PCI con statine
La facilitazione alla PCI con statine Bertinoro, 16 aprile 2010 Aldo Miola, M.D., Ph.D. Medical Manager Primary Care Pfizer Italy 1 Are statins beneficial in patients undergoing PCI? 2 3 Statin therapy
Dental treatment of a patient with long QT syndrome under moderate sedation with target-controlled infusion of propofol
Case Report pissn 2383-9309 eissn 2383-9317 J Dent Anesth Pain Med 2015;15(3):161-165 http://dx.doi.org/10.17245/jdapm.2015.15.3.161 Dental treatment of a patient with long QT syndrome under moderate sedation
Natural History of the Electrocardiographic Pattern of Early Repolarization in Ambulatory Patients
Natural History of the Electrocardiographic Pattern of Early Repolarization in Ambulatory Patients Chandana Adhikarla, MD b, *, Madhavi Boga, MD b, Alexander D. Wood b,c, and Victor F. Froelicher, MD a,b
Review of Important ECG Findings in Patients with Syncope Joseph Toscano, MD
92 Review of Important ECG Findings in Patients with Syncope Joseph Toscano, MD Abstract Guidelines recommend 12-lead ECG as an important test to perform in patients with syncope. Though the incidence
Equine Cardiovascular Disease
Equine Cardiovascular Disease 3 rd most common cause of poor performance in athletic horses (after musculoskeletal and respiratory) Cardiac abnormalities are rare Clinical Signs: Poor performance/exercise
Long QT Syndrome Patient Information Leaflet
Long QT Syndrome The Heart Rhythm Charity Promoting better understanding, diagnosis, treatment and quality of life for individuals with cardiac arrhythmias Long QT Syndrome Patient Information Leaflet
Long QT Syndrome: A Pamphlet for Community Awareness in Prevention of Sudden Cardiac Death in the Young
Long QT Syndrome: A Pamphlet for Community Awareness in Prevention of Sudden Cardiac Death in the Young Bauke Pier Lettenga Helena Lustig Bachelor s Thesis November 2009 School of Health and Social Studies
The choice for quality ECG arrhythmia monitoring
GE Healthcare EK-Pro The choice for quality ECG arrhythmia monitoring David A. Sitzman, MSEE. Mikko Kaski, MSAM. Ian Rowlandson, MSBE. Tarja Sivonen, RN. Olli Väisänen, MD, PhD. Clinical care environments
Sudden unexplained death in infancy and long QT syndrome. Jonathan Robert Skinner
Sudden unexplained death in infancy and long QT syndrome. Jonathan Robert Skinner Greenlane Paediatric and Congenital Cardiac Services, Starship Children s Hospital, Park Road, Grafton, Auckland New Zealand.
Methods SOO G. KIM, MD, FACC, STEVEN W. SEIDEN, MD, JEFFREY A. MATOS, MD, LAWRENCE E. WASPE, MD, FACC, JOHN D. FISHER, MD, FACC
lacc Vol. 6, No.3 539 Discordance Between Ambulatory Monitoring and Programmed Stimulation in Assessing Efficacy of Class IA Antiarrhythmic Agents in Patients With Ventricular Tachycardia SOO G. KIM, MD,
The long-qt syndrome (LQTS) is an inherited or acquired
Compound Mutations A Common Cause of Severe Long-QT Syndrome Peter Westenskow, BS; Igor Splawski, PhD; Katherine W. Timothy, BS; Mark T. Keating, MD; Michael C. Sanguinetti, PhD Background Long QT syndrome
Atrial Fibrillation 2014 How to Treat How to Anticoagulate. Allan Anderson, MD, FACC, FAHA Division of Cardiology
Atrial Fibrillation 2014 How to Treat How to Anticoagulate Allan Anderson, MD, FACC, FAHA Division of Cardiology Projection for Prevalence of Atrial Fibrillation: 5.6 Million by 2050 Projected number of
Genetic analysis of Brugada syndrome and congenital long- QT syndrome type 3 in the Chinese
JCDR Original Paper Genetic analysis of Brugada syndrome and congenital long- QT syndrome type 3 in the Chinese Peng Liang, Wenling Liu 1, Cuilan Li 1, Wuhua Tao 2, Lei Li 1, Dayi Hu 1 Heart Center, Beijing
Efficient Evaluation of Chest Pain
Efficient Evaluation of Chest Pain Vikranth Gongidi, DO FACC FACOI Indian River Medical Center Vero Beach, FL No Disclosures Outline Background Chest pain pathway Indications for stress test Stress test
Syncope. enough to include disorders such as epileptic seizures and concussion. January 14-15, 2011 SCA Conference 1
Syncope and Atypical Seizures Ravi Mandapati, M.D., FACC.; FHRS Director, Specialized Program for Arrhythmias in Congenital Heart Disease UCLA Cardiac Arrhythmia Center David Geffen School of Medicine
Wide-Complex Tachycardias in the ED: Myths and Pitfalls
Wide-Complex Tachycardias in the ED: Myths and Pitfalls, FACEP, FAAEM Professor and Vice Chair Director, Emergency Cardiology Fellowship Department of Emergency Medicine University of Maryland School of
How do you decide on rate versus rhythm control?
Heart Rhythm Congress 2014 How do you decide on rate versus rhythm control? Dr Ed Duncan Consultant Cardiologist & Electrophysiologist Define Rhythm Control DC Cardioversion Pharmacological AFFIRM study
Genetic Predisposition to Ventricular Arrhythmias and. Sudden Death in Hypertrophic Cardiomyopathy
Dott.ssa Daria Santini Dottorato di Ricerca in Medicina Sperimentale Genetic Predisposition to Ventricular Arrhythmias and Sudden Death in Hypertrophic Cardiomyopathy Background Hypertrophic cardiomyopathy
DEVICE RECALLS: The Era of Regulation and Outcome Metrics: Optimizing Benefits and Managing Risks
DEVICE RECALLS: The Era of Regulation and Outcome Metrics: Optimizing Benefits and Managing Risks Kenneth A. Ellenbogen, MD Kontos Professor & Chairman Virginia Commonwealth University School of Medicine
Tips and Tricks to Demystify 12 Lead ECG Interpretation
Tips and Tricks to Demystify 12 Lead ECG Interpretation Mission: Lifeline North Dakota Regional EMS and Hospital Conference Samantha Kapphahn, DO Essentia Health- Interventional Cardiology June 5th, 2014
Over the past decade, the discovery of mutations in
Review Novel Insights in the Congenital Long QT Syndrome Xander H.T. Wehrens, MD; Marc A. Vos, PhD; Pieter A. Doevendans, MD; and Hein J.J. Wellens, MD Background: The congenital long QT syndrome is a
Professor Rose Anne Kenny, St James Hospital &Trinity College, Dublin
Syncope Presentation and Investigation in the Acute Setting Professor Rose Anne Kenny, St James Hospital &Trinity College, Dublin Definition- Presentation Syncope is a syndrome consisting of a relatively
Basics of Pacing. Ruth Hickling, RN-BSN Tasha Conley, RN-BSN
Basics of Pacing Ruth Hickling, RN-BSN Tasha Conley, RN-BSN The Cardiac Conduction System Cardiac Conduction System Review Normal Conduction Conduction QRS QRS Complex Complex RR PP ST ST segment segment
The Electrocardiogram (ECG)
The Electrocardiogram (ECG) Preparation for RWM Lab Experiment The first ECG was measured by Augustus Désiré Waller in 1887 using Lippmann's capillary electrometer. Recorded ECG: http://www.youtube.com/watch_popup?v=q0jmfivadue&vq=large
The Emerging Atrial Fibrillation Epidemic: Treat It, Leave It or Burn It?
The Emerging Atrial Fibrillation Epidemic: Treat It, Leave It or Burn It? Indiana Chapter-ACC 17 th Annual Meeting Indianapolis, Indiana October 19, 2013 Deepak Bhakta MD FACC FACP FAHA FHRS CCDS Associate
the basics Perfect Heart Institue, Piyavate Hospital
ECG INTERPRETATION: the basics Damrong Sukitpunyaroj MD Damrong Sukitpunyaroj, MD Perfect Heart Institue, Piyavate Hospital Overview Conduction Pathways Systematic Interpretation Common abnormalities in
New in Atrial Fibrillation
New in Atrial Fibrillation September 2011 Stroke prevention more options Rhythm Control -drugs - alternatives to drugs; ablation Rate Control - pace + ablate A-FIB Dell Stroke Risk AFib Two Principles
Application for a Marketing Authorisation: Requirements and Criteria for the Assessment of QT Prolonging Potential
Application for a Marketing Authorisation: Requirements and Criteria for the Assessment of QT Prolonging Potential Bundesinstitut für Arzneimittel Dr. med. Clemens Mittmann Bundesinstitut für Arzneimittel
Echocardiography Guided Cardiac Resynchronization Therapy in Patients with Symptomatic Heart Failure and Narrow QRS Complex
Echocardiography Guided Cardiac Resynchronization Therapy in Patients with Symptomatic Heart Failure and Narrow QRS Complex Johannes Holzmeister, M.D. University of Zurich, Zurich, Switzerland on behalf
Presenter Disclosure Information
2:15 3 pm Managing Arrhythmias in Primary Care Presenter Disclosure Information The following relationships exist related to this presentation: Raul Mitrani, MD, FACC, FHRS: Speakers Bureau for Medtronic.
Diagnosis Code Crosswalk : ICD-9-CM to ICD-10-CM Cardiac Rhythm and Heart Failure Diagnoses
Diagnosis Code Crosswalk : to 402.01 Hypertensive heart disease, malignant, with heart failure 402.11 Hypertensive heart disease, benign, with heart failure 402.91 Hypertensive heart disease, unspecified,
MONITORAGGIO ECG: DIAGNOSI NEL PAZIENTE CON SINCOPE
Bologna, 1.2.2013 MONITORAGGIO ECG: DIAGNOSI NEL PAZIENTE CON SINCOPE Marco Tomaino Divisione di Cardiologia/Servizio Aritmologico/Syncope Unit Multidisciplinare Ospedale Centrale di Bolzano ECG Monitoring
Platelet Function Testing vs Genotyping : Focus on Pharmacogenomics of Clopidogrel. Kiyuk Chang, M.D., Ph.D.
Platelet Function Testing vs Genotyping : Focus on Pharmacogenomics of Clopidogrel Kiyuk Chang, M.D., Ph.D. Cardiovascular Center & Cardiology Division Seoul St. Mary s Hospital The Catholic University
1p36 and the Heart. John Lynn Jefferies, MD, MPH, FACC, FAHA
1p36 and the Heart John Lynn Jefferies, MD, MPH, FACC, FAHA Director, Advanced Heart Failure and Cardiomyopathy Services Associate Professor, Pediatric Cardiology and Adult Cardiovascular Diseases Associate
CARDIAC ELECTROPHYSIOLOGY, ARRHYTHMIAS AND PACING. Medical Knowledge. Goals and Objectives PF EF MF LF Aspirational
Know the histology and gross anatomy of the normal sinoatrial node, atrial conduction pathways, atrioventricular (AV) junction and nod, His bundle, conduction fascicles and terminal intra-ventricular conduction