Márcio Duarte Albasini Mourão

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1 Márcio Duarte Albasini Mourão 42 Orchard Lane, Columbus, OH 43214, (812) EDUCATION Indiana University Bloomington, Indiana, USA and Gulbenkian Institute, Portugal May 2011 PhD in Informatics (Computational Biology and Complex systems) Minor Molecular Biology Thesis title - Reverse engineering the mechanisms and the dynamical behavior of complex biochemical pathways Advisor: Santiago Schnell Universidade Técnica de Lisboa (UTL) Instituto Superior Técnico (IST), Portugal May 2005 Masters of Informatics, Engineering and Computers, Specialization: Artificial Intelligence Thesis title - Management and Representation of Domains in Dialogue Systems (written in Portuguese) Advisor: Nuno Mamede Universidade Técnica de Lisboa (UTL) Instituto Superior Técnico (IST), Portugal May 2002 Licentiate of Informatics, Engineering and Computers, Specialization: Artificial Intelligence POSTDOCTORAL TRAINING College of Arts and Sciences, Mathematical Biosciences Institute (MBI) Ohio State University, USA 2013-Pres. Postdoctoral Researcher Investigates the kinetic steady state of microtubule arrays in plant-based systems as well as the contribution of individual microtubule dynamical parameters and microtubule interactions to the self-organization. Investigates the role of macromolecular crowding in diffusion and reaction kinetics. Investigates Drosophila flies response to pheromone sensing and mating. Investigates the mrna degradation pathway. Reviews scientific papers. Department of Molecular & Integrative Physiology University of Michigan, USA Postdoctoral Researcher Applies both computational and statistical approaches to investigate the performance of different methods in the prediction of significant periods of mono and bi-oscillatory data. Investigates how different number of points, cycles and noise in oscillatory data affect different methods in the prediction of significant periods of mono and bi-oscillatory data. Uses computational and stochastic methods to investigate the kinetic steady state of cortical microtubule arrays in plant based systems. Investigates the contribution of individual microtubule dynamical parameters and microtubule interactions to the self-organization of microtubule arrays in plant based systems. Applies lattice simulations to investigate the role of macromolecular crowding in diffusion and reaction kinetics. Investigates fractal kinetics behavior in biochemical reactions occurring in crowded environments. Organizes the lab meetings and mentors undergraduate students. Reviews scientific papers and helps writing grants.

2 TEACHING Department of Mathematics Michigan State University, USA Visiting Instructor Calculus I (Spring 2010/2011) Mathematical Biology (Fall 2010/2011) Department of Engineering Informatics (DEI) Universidade Técnica de Lisboa (UTL), Portugal Teaching Assistant Introduction to Programming (Fall 2004/2005) Distributed Systems (Spring 2003/2004) Architecture and Organization of Enterprise Information Systems (Fall 2003/2004) RESEARCH INTERESTS The long term interest is to investigate self-organization in biological, social, economical or even political systems. Currently, the focus is on the cytoskeleton microtubule, and the role of space in diffusion and reaction kinetics. The work involves a combination of both theoretical and computational models. HONORS AND AWARDS Postdoctoral Fellowship Mathematical Biosciences Institute (MBI), Ohio State University Pres. FCT scholarship Foundation for Science and Technology and Gulbenkian Institute (IGC). PUBLICATIONS In Preparation S. Pitchiaya, M. A. Mourão, S. Schnell, N. Walter. Number and size effects of P-Bodies in protein formation. Research Article. Z. Harvanek, M. A. Mourão, S. Schnell, S. Pletcher. Reversibility of fly mortality rates due to heterogeneous populations of mating expectations. Research Article. M. A. Mourão, S. Shaw. The role of nucleation, extinction and severing in the microtubule plant cortex. Research Article. M. Costa, M. A. Mourão. The role of ATXN3 in neuro-degenerative diseases. Research Article. M. A. Mourão, J. Bisher, S. Schnell. Macromolecular crowding effects in enzymatic reactions. Review Article. M. A. Mourão, S. Schnell. Macromolecular crowding effects on cell physiology. Perspective Article. Peer-Reviewed M. A. Mourão, L. Satin, S. Schnell (2014). Optimal experimental design to estimate statistically significant oscillatory periods in time course data. PLOS ONE 9, e DOI: /journal.pone

3 M. Mourão, D. Kreitman and S. Schnell (2014). Unravelling the impact of obstacles in diffusion and kinetics of an enzyme catalysed reaction. Physical Chemistry Chemical Physics 16, DOI: /C3CP52417E. L. Zheng, Y. J. Seon, M. A. Mourão, S. Schnell, D. Kim, H. Harada, S. Papagerakis and P. Papagerakis (2013). Circadian rhythms regulate amelogenesis. Bone. DOI: /j.bone M. A. Mourão, S. Schnell, S. L. Shaw (2011). Macroscopic simulations of microtubule dynamics predict two steady-state processes governing array morphology. Computational Biology & Chemistry 35, DOI: /j.compbiolchem M. A. Mourão, J. Srividhya, P. E. McSharry, E. J. Crampin and S. Schnell (2011). MIKANA: Method for Inferring Kinetics and Network Architecture. PLoS ONE 6, e DOI: /journal.pone J. Srividhya, M. A. Mourão, E. J. Crampin, S. Schnell (2010). Enzyme kinetics: from experiments to computational mechanism reconstruction. Computational Biology & Chemistry 34, DOI: /j.compbiolchem João Neto, Renato Cassaca, Márcio Viveiros, Márcio Mourão (2006). Design of a Multimodal Input Interface for a Dialogue System. Lecture Notes in Computer Science 3960/2006, DOI: / _18. J. Graça, M. A. Mourão, O. Anunciação, P. Monteiro, H. S. Pinto, V. Loureiro (2005). Ontology Building Process: The Wine Domain. EFITA / WCCA, Proceedings of the 5 th Conference of the European Federation for Information Technology in Agriculture, Food and Environment. M. A. Mourão, Renato Márcio de França Cassaca, Nuno J. Mamede (2004). An Independent Domain Dialog System Through a Service Manager. Lecture Notes in Computer Science DOI: / _15. M. A. Mourão, Pedro Daniel Santiago Madeira, Nuno J. Mamede (2003). Interpretations and Discourse Obligations in a Dialog System. Lecture Notes in Computer Science 2721, DOI: / _31. Pedro Daniel Santiago Madeira, M. A. Mourão, Nuno J. Mamede (2003). STAR - A Multiple Domain Dialog Manager. Proceedings of the 5 th International Conference on Enterprise Information Systems, Thesis M. A. Mourão (2011), Reverse engineering the mechanisms and the dynamical behavior of complex biochemical pathways [PhD Thesis]. M. A. Mourão (2005), Management and Representation of Domains in Dialogue Systems [Master Thesis]. Non-academic publications Raia Diplomática Márcio Mourão & Daniel Sobral. Ciência holística. Raia Diplomática. 2. Márcio Mourão & Daniel Sobral. Medicina personalizada. Raia Diplomática. 3. Márcio Mourão & Daniel Sobral. Nanomedicina. Raia Diplomática. 4. Márcio Mourão & Daniel Sobral. Células estaminais. Raia Diplomática. 5. Márcio Mourão & Daniel Sobral. A rejeição de transplantes: problema resolvido? Raia Diplomática. 6. Márcio Mourão & Daniel Sobral. Alternatica para uma cura ao cancro? Raia Diplomática. Kompleta (Semanário Notícias da Madeira, Portugal) Márcio Mourão. Reprodução sexual. Kompleta. 8. Márcio Mourão. Células estaminais. Kompleta. 9. Márcio Mourão. Porque seguram as mulheres os bebés no braço esquerdo. Kompleta. 10. Márcio Mourão. Sangue. Kompleta.

4 11. Márcio Mourão. Fotossíntese. Kompleta. 12. Márcio Mourão. Uma explicação evolucionária para as emoções. Kompleta. 13. Márcio Mourão. O tabaco. Kompleta. 14. Márcio Mourão. O sistema imunitário. Kompleta. 15. Márcio Mourão. O cancro. Kompleta. 16. Márcio Mourão. A gripe. Kompleta. 17. Márcio Mourão. Biologia do desenvolvimento. Kompleta. 18. Márcio Mourão. A SIDA. Kompleta. 19. Márcio Mourão. Evolução ou criação. Kompleta. 20. Márcio Mourão. O ébola. Kompleta. 21. Márcio Mourão. Porque envelhecemos e morremos. Kompleta. 22. Márcio Mourão. A vida e a morte. Kompleta. 23. Márcio Mourão. A estrutura hierárquica da vida. Kompleta. 24. Márcio Mourão. A hibernação. Kompleta. 25. Márcio Mourão. O transplante de orgãos. Kompleta. 26. Márcio Mourão. Os diabetes. Kompleta. 27. Márcio Mourão. A clonagem. Kompleta. 28. Márcio Mourão. SNP. Kompleta. 29. Márcio Mourão. Medicina personalizada. Kompleta. 30. Márcio Mourão. A mudança climática. Kompleta. 31. Márcio Mourão. Árvores filogenéticas. Kompleta. PRESENTATIONS M. A. Mourão, D. Kreitman, S. Schnell. Unraveling the role of obstacles in diffusion and reaction kinetics of an enzyme catalyzed reaction (August 2014). SIAM: Life Sciences Conference, Charlotte, N. Carolina. Oral Presentation. M. A. Mourão, D. Kreitman and S. Schnell. Unravelling the impact of obstacles in diffusion and kinetics of an enzyme catalysed reaction (February 2014). 54 th Annual Biophysics Meeting, San Francisco. Poster Presentation. M. A. Mourão, D. Kreitman, S. Schnell. Designing simulations to investigate reactions inside the cell (February 2014). MBI Postdoctoral Seminar, Mathematical Biosciences Institute (MBI), Columbus, Ohio. Oral Presentation. M. A. Mourão, D. Kreitman, S. Schnell. Unraveling the role of obstacles in diffusion and reaction kinetics of an enzyme catalyzed reaction (August 2013). Workshop for Young Researchers in Mathematical Biology (WYRMB), Mathematical Biosciences Institute (MBI), Columbus, Ohio. Poster Presentation. M. A. Mourão, S. Schnell. MIKANA: Method for the Inference of Kinetics and Network Architecture (September 2010). NCIBI Tools and Technology. Michigan State University, Department of Mathematics, Mathematical Biology Seminars. Oral Presentation. M. A. Mourão, S. Schnell. MIKANA: Method for the Inference of Kinetics and Network Architecture (May 2010). NCIBI Tools and Technology. Center for Computational Medicine and Bioinformatics (CCMB), University of Michigan. Oral Presentation. M. A. Mourão, S. Shaw, S. Schnell. Stochastic simulations of interphase microtubule arrays (February 2010). Biophysical Society 54 th Annual Meeting. San Francisco, CA. Poster Presentation. M. A. Mourão, S. Shaw, S. Schnell. Stochastic simulations of cortical microtubule arrays in plant systems. Society for Mathematical Biology (July 2008). Toronto, Ontario. Poster Presentation. M. A. Mourão, J. Srividhya, E. J. Crampin, P. E. McSharry, S. Schnell. Optimal experimental design of a reaction inference methodology (July 2007). Society for Mathematical Biology. San Jose, CA. Oral Presentation. M. A. Mourão, N. Mamede. An Independent Domain Dialogue System Through a Service Manager (2004), EsTAL - España for Natural Language Processing Alicante, Spain. Oral Presentation. M. A. Mourão, N. Mamede. Interpretations and Discourse Obligations in a Dialogue System (2003), PROPOR, 6th Workshop on Computational Processing of the Portuguese Language Written and Spoken, Faro, Portugal. Oral Presentation.

5 MENTORING Undergraduate Doree Kreitmann (Undergrad student in the Department of Mathematics at UM). ARTICLE REVIEWS Journals Mathematical Biosciences. Physical Biology. PloS ONE. Physical Chemistry. SOFTWARE MIKANA - Method for Inferring Kinetics And Network Architecture - A freely downloadable software with a user friendly GUI for extracting reaction mechanisms from experimental time series data: URL: COMPUTER SKILLS C, C++, Java, Perl. Mathematica, Matlab. PREVIOUS RESEARCH SUPPORT 09/ /2014 James S. McDonnell Foundation Proposal 9184 Identification of bistable network topologies associated with toxic aggregation thresholds found in conformational diseases Principal Investigator: Santiago Schnell Role: Postdoctoral Research Fellow Total funds (4 years): $413,488 MEMBERSHIPS IN PROFESSIONAL SOCIETIES Society for Mathematical Biology (SMB). Society for Industrial and Applied Mathematics (SIAM). Biophysical Society.

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