Changes to CPT Coding for 2015

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1 Changes to CPT Coding for 2015 The American Medical Association (AMA) publishes the Current Procedural Terminology (CPT) coding manual on an annual basis. For 2015, the pathology and laboratory section of the CPT manual includes 107 new Category I CPTs, including three new Tier I CPTs, 48 deleted CPTs, and 32 CPT description revisions. (See the table below for assays relevant to MedTox clients.) LabCorp will begin submitting the AMA s 2015 CPT codes, effective January 1, 2015, unless other payer guidance is received. The CPT codes presented below are intended as general guidelines and are based on the AMA s 2015 CPT code manual. Please confirm with the Each billing party is responsible for its own CPT coding. The table below does not include any custom panels created for individual clients. We hope that your office staff will find this information of benefit. Please contact your local MedTox service representative if you have questions. Drug Testing Procedures Test Name Test Nº CPT 2014 CPT Acetylmorphine Confirmation, Urine Acetaminophen (Tylenol, Datril ), Serum Acetaminophen (Tylenol, Datril ), Urine Acetazolamide (Diamox ) Acetone Acetyl Fentanyl Alcohol Biomarkers Quantitative, Urine Alcohol Biomarkers, Urine Alcohol, Ethyl Legal, Blood Alcohol, Ethyl Legal, Urine Alcohol, Ethyl Urine Alcohol, Ethyl, Blood Alcohol, Ethyl, Vitreous Fluid Alcohol, Isopropyl Alcohol, Methyl Alpha PVP Alprazolam (Xanax ), Serum Alprazolam Confirmation, Quantitative, Urine Amantadine (Symmetrel ) Amikacin (Amikin ) Amiodarone (Cordarone ) and Desethylamiodarone Amitriptyline (Elavil ) and Nortriptyline ; Amobarbital (Amytal ) Amoxapine (Asendin ) and 8-Hydroxyamoxapine Amphetamine and Methamphetamine Confirmation, Urine, Qualitative (Clinical use only) Amphetamine Confirmation, Serum

2 Amphetamines Analysis, Serum Amphetamines Analysis, Whole Blood Amphetamines, Expanded + MDEA Quantitative Confirmation to 500 ng/ml ; Amphetamines, Expanded + MDEA Quantitative Confirmation to LOQ ; Amphetamines, Quantitative Confirmation to 500 ng/ml Amphetamines, Quantitative Confirmation to LOQ Anabolic Steroid Screen, Urine ; Antidepressant Drug Screen, Qualitative ; ; 80337; Antidepressant Drug Screen, Quantitative ; 80337; Antidepressant Drug Screen, Urine, Quantitative ; 80337; Antidepressant Profile, Qualitative, Expanded, Urine ; 80337; Antihistamine Screen Antipsychotic Drug Screen, Serum/Plasma (x11) Antipsychotic Drug Screen, Urine Antipsychotic Drug Screen, Whole Blood Aripiprazole (Abilify ) Atenolol (Tenormin ) Atomoxetine (Strattera ), Serum Azathioprine (Imuran ) as 6-Mercaptopurine Baclofen (Lioresal ) Barbiturate Analysis, Serum Barbiturate Analysis, Whole Blood Barbiturate Confirmation, Quantitative, Urine Barbiturate Confirmation, Serum Forensic Benzodiazepine Analysis, Serum Benzodiazepine Analysis, Whole Blood Benzodiazepine Confirmation, Qualitative, Urine Benzodiazepine Confirmation, Quantitative, Urine Benzodiazepine Confirmation, Serum, Quantitative Benzodiazepine Confirmation, Whole Blood, Quantitative Benztropine (Cogentin ), Serum Blood Drugs of Abuse, Whole Blood (x8) Blood Drugs of Abuse, Whole Blood (x6) Blood Drugs of Abuse, Whole Blood With EtOH (x11) Blood Drugs of Abuse, With Meperidine and Tramadol, Whole Blood (x11); ; 80302; 80362; Brodifacoum Bupivacaine (Marcaine ) Buprenorphine (Subutex, Buprenex, Suboxone ), Serum/Plasma Buprenorphine (Subutex, Buprenex, Suboxone ), Whole Blood Buprenorphine Screen and Confirmation, Urine Bupropion (Wellbutrin, Zyban ) and Hydroxybupropion Buspirone (Buspar ) Butalbital (Fiorinal ) Butorphanol (Stadol ) Caffeine, Serum

3 Caffeine, Urine Cannabinoid (THC) Confirmation, Serum Cannabinoid Analysis, Serum Cannabinoid Analysis, Whole Blood Carbamazepine (Tegretol ) Carbamazepine (Tegretol ) and Carbamazepine-10,11-Epoxide ; Carbamazepine (Tegretol ), Unbound and Total ; ; Carbamazepine and 10,11-Epoxide, Unbound ; Carbamazepine and Epoxide, Free And Total ; 80156; 82491(x2) Carbamazepine, Unbound Carboxy-THC (Marijuana Metabolite) Confirmation, Qualitative, Urine Carboxy-THC (Marijuana Metabolite) Confirmation, Quantitative, Urine Carisoprodol (Soma ) and Meprobamate ; Carisoprodol (Soma ) and Meprobamate, Urine Cathinone and Methcathinone, Urine Chloramphenicol (Chloromycetin ) Chlordiazepoxide (Librium ) and Desmethylchlordiazepoxide Chlorpheniramine (Chlortrimeton ), Serum Chlorpheniramine (Chlortrimeton ), Urine Chlorpromazine (Thorazine ) Chlorpropamide (Diabinese ) Citalopram (Celexa ) Clobazam, Serum/Plasma Clomipramine (Anafranil ) and Desmethylclomipramine Clonazepam With Metabolite Klonopin Clonazepam,Urine as Metabolite Clonidine (Catapres ) Clorazepate (Tranxene ) as Desmethyldiazepam Clozapine (Clozaril ) and Norclozapine Cocaethylene Confirmation, Quantitative, Urine Cocaethylene Confirmation, Serum Cocaine Analysis, Serum Cocaine Analysis, Whole Blood Cocaine and Metabolite Confirmation, Serum/Plasma, Whole Blood, VIT Cocaine and Metabolite Confirmation, Whole Blood Cocaine Confirmation, Qualitative, Urine Cocaine Confirmation, Quantitative, Urine Codeine and Morphine Confirmation, Serum Codeine Confirmation, Serum ; Compliance Amphetamine Confirmation, Urine ; Compliance Barbiturate Confirmation, Urine Compliance Benzodiazepine Confirmation, Urine Compliance Buprenorphine Confirmation, Urine Compliance Cocaine Confirmation, Urine

4 Compliance Drug Analysis, Urine (No THC) (x3); 80100; 80154; 82055; 82145; 82520; 82570; 83840; Compliance Drug Analysis, Urine, With Reported Medications (x4); 80100; 80154; 82055; 82145; 82520; 82570; 83840; ; 80302; 80326; 80331; 80334; 80337; 80338; 80341; 80344; 80346; 80348; 80353; 80354; 80355; 80357; 80358; 80359; 80360; 80361; 80364; 80365; 80366; 80367; 80368; 80370; 80371; 80372; 80373; 80377; 82570; ; 80302; 80326; 80331; 80334; 80337; 80338; 80341; 80344; 80346; 80348; 80353; 80354; 80355; 80357; 80358; 80359; 80360; 80361; 80364; 80365; 80366; 80367; 80368; 80370; 80371; 80372; 80373; 80377; 82570; Compliance Drug Screen 10 With Reflex Confirmation, Urine ; 80101(x10) 80301; 80324; 80346; 80348; 80353; 80354; 80358; 80359; 80361; 80365; Compliance Fentanyl Confirmation, Urine Compliance Methadone Confirmation, Urine Compliance Opiate/Opioid Confirmation, Urine ; 80354; 80358; 80361; 80365; Compliance Propoxyphene Confirmation, Urine Compliance Tapentadol Confirmation, Urine Compliance THC Confirmation, Urine ; Comprehensive Blood Drug Screen (x10); 80100; Comprehensive Drug Analysis, Urine (x4); 80100; 80154; 82055; 82145; 82520; 82570; 83840; Cyclobenzaprine (Flexeril ) Cyclosporine (Sandimmune ) Desalkylflurazepam Desipramine (Norpramin ) Desomorphine, Urine Dextromethorphan (DM), Serum Dextromethorphan and Metabolite, Urine, Quantitative Diazepam (Valium ) and Desmethyldiazepam Digoxin (Lanoxin, Lanoxicaps ) Digoxin, Unbound Diltiazem (Cardizem, Dilacor ) ; 80302; 80326; 80331; 80334; 80337; 80338; 80341; 80344; 80346; 80348; 80353; 80354; 80355; 80357; 80358; 80359; 80360; 80361; 80364; 80365; 80366; 80367; 80368; 80370; 80371; 80372; 80373; 80377; 82570;

5 Diphenhydramine (Benadryl ), Serum/Blood Diphenhydramine (Benadryl ), Urine Diuretic Screen, Urine Divalproex (Depakote ) as Valproic Acid Doxepin (Sinequan, Adapin ) and Desmethyldoxepin Drugs of Abuse Screen, 2, Meconium (x2) Drugs of Abuse Screen, 3, Meconium (x3) Drugs of Abuse Screen, 3, Meconium (x3) Drugs of Abuse Screen, 4, Meconium (x4) Drugs of Abuse Screen, 4, Meconium (x4) Drugs of Abuse Screen, 4, Meconium (x4) Drugs of Abuse Screen, 4, Meconium (x4) Drugs of Abuse Screen, 5, Meconium (x5) Drugs of Abuse Screen, 5, Meconium (x5) Drugs of Abuse Screen, 5, Meconium (x5) Drugs of Abuse Screen, 5, Urine (x5) Drugs of Abuse Screen, 6, Meconium (x6) Drugs of Abuse Screen, 6, Meconium (x6) Drugs of Abuse Screen, 6, Serum (x6) Drugs of Abuse Screen, 7, Meconium (x7) Drugs of Abuse Screen, 7, Urine (x7) Drugs of Abuse Screen, 8, Meconium (x8) Drugs of Abuse Screen, 8, Serum (x8) Drugs of Abuse Screen, 8, Urine (x8) Drugs of Abuse Screen, 8, Urine ; 80101(x8) Drugs of Abuse Screen, 9, Meconium (x9) Drugs of Abuse Screen, 10, Meconium (x10) Drugs of Abuse Screen, 10, Serum (x10) Drugs of Abuse Screen, 10, Whole Blood (x10) Drugs of Abuse Screen, 11, Serum (x11) Drugs of Abuse Screen, 11, Urine (x11) Drugs of Abuse Screen, Oral Fluid (x6) Drugs of Abuse, 11, Serum/Plasma With Tramadol and Mepridine (x2); 80101(x11) 80301; 80302; 80362; Drugs of Abuse, 11, Whole Blood With Tramadol and Meperidine (x2); 80101(x11) 80301; 80302; 80362; Drugs of Abuse, Oral Fluid Cotinine Duloxetine (Cymbalta ) Duloxetine (Cymbalta ), Urine Escitalopram (Lexapro ), Serum or Plasma Escitalopram (Lexapro ), Urine Ethosuximide (Zarontin ) Ethotoin (Peganone ) Ethylene Glycol, Serum and Blood Ezogabine, Plasma Felbamate (Felbatol ) Fentanyl (Innovar, Sublimaze ), Serum

6 Fentanyl (Innovar, Sublimaze ), Urine Forensic Fentanyl (Innovar, Sublimaze ), Urine Forensic Fentanyl (Innovar, Sublimaze ), Whole Blood Fentanyl and Analogues, Urine Fioricet (Butalbital, Acetaminophen, Caffeine) ; 80155; ; 80329; Flecainide (Tambocor ) Flunitrazepam (Rohypnol ) Confirmation, Urine Forensic Flunitrazepam (Rohypnol ) Screen and Confirmation, Urine Forensic Flunitrazepam Confirmation, Serum Fluoxetine (Prozac ) and Norfluoxetine Fluphenazine (Prolixin ), Serum Flurazepam (Dalmane ) and Desalkylflurazepam Forensic Drug Screen Analysis, (One nontissue specimen type allowed) ; 80101(x20); Free Morphine (Unconjugated) Confirmation, Urine Gabapentin (Neurontin ) Gabapentin, Urine Gastric Drug Screen (x2); 80101(x15); Gentamicin (Garamycin ) Gentamicin in Cerebrospinal Fluid (CSF) Haloperidol (Haldol ), Serum Heroin Analysis, Serum Heroin Confirmation, Quantitative, Urine ; Heroin Confirmation, Serum/Plasma/Whole Blood (x2) 80356; Hydrocarbons, Whole Blood ; Hydrochlorothiazide (Hydrodiuril ) Hydrocodone (Hycodan ), Serum Forensic Hydrocodone and Metabolite, Confirmation, Quantitative, Urine Hydromorphone Confirmation, Serum Ibuprofen (Motrin, Advil, Nuprin ), Serum Ibuprofen (Motrin, Advil, Nuprin ), Urine Imipramine (Tofranil ) and Desipramine ; Ipecac Use Markers, Serum or Plasma Ipecac Use Markers, Urine Ketamine and Metabolite, Quantitative, Whole Blood Ketamine Screen, Urine Kratom (Mitragynine), Urine, Quantitative Lacosamide (Vimpat ) Lamotrigine (Lamictal ) Lamotrigine (Lamictal ), Unbound Levetiracetam (Keppra ) Lidocaine (Xylocaine ) Lisdexamfetamine as Metabolite (Amphetamine), Serum Liver Tissue Screen (x15); 80100(x2)

7 Lorazepam (Ativan ), Serum Lorazepam Confirmation, Quantitative, Urine Lortab /Lorcet (Hydrocodone and Acetaminophen) ; ; Loxapine (Loxitane ) and 8-Hydroxyloxapine LSD Analysis, Serum LSD Analysis, Urine LSD Confirmation, Quantitative, Urine Maprotiline (Ludiomil ) MDMA (Methylenedioxymethamphetamine) Confirmation, Quantitative, Urine MDMA (Methylenedioxymethamphetamine), Serum/Plasma/Whole Blood Meconium Amphetamines Confirmation Meconium Barbiturate Confirmation Meconium Benzodiazepine Confirmation Meconium Cannabinoids (THC) Confirmation Meconium Cocaine Confirmation Meconium Methadone Confirmation Meconium Opiate Confirmation ; Meconium Oxycodone Confirmation Meconium Phencyclidine (PCP) Confirmation Meperidine (Demerol ) and Normeperidine, Serum Meperidine (Demerol ) and Normeperidine, Urine Mephedrone, MDPV and Methylone, Urine Mephenytoin (Mesantoin ) and Normephenytoin Mephobarbital (Mebaral ) Mephobarbital (Mebaral ) and Phenobarbital ; ; Meprobamate (Equanil ) Mercaptopurine (6-MP, Purinethol ) Mescalin/Psilocin, Urine Mescaline, Urine Methadone (Dolophine ), Serum Methadone (Dolophine ), Serum Forensic Methadone Analysis, Serum Methadone Analysis, Whole Blood Methadone Confirmation, Qualitative, Urine Methadone Confirmation, Quantitative, Urine Methamphetamine Confirmation, Serum Methaqualone Confirmation, Urine Methotrexate (Mexate ) Methsuximide (Celontin ) as Desmethylmethsuximide Methylphenidate (Ritalin ) and Metabolite, Urine Methylphenidate (Ritalin ), Serum Metoprolol (Lopressor ) Midazolam (Versed ), Serum Midazolam Confirmation, Quantitative, Urine

8 Mirtazapine (Remeron ) Mitotane (Lysodren ) Morphine Analysis, Whole Blood Morphine Confirmation, Quantitative, Urine Morphine Confirmation, Serum/Plasma/Whole Blood Naproxen (Aleve, Naprosyn, Anaprox ) NBOMe Hallucinogens, Urine Nefazodone (Serzone ) Nicotine and Cotinine Screen, Serum Nicotine and Cotinine Screen, Urine Nicotine and Cotinine, Quantitative, Whole Blood Nitrazepam (Mogadon ) Non-Steroidal Antiinflammatory Drug (NSAID) Screen, Serum Nortriptyline (Aventyl ) Olanzapine (Zyprexa ) Opiate and Opioid Confirmation, Urine ; 80354; 80358; 80361; 80364; 80365; 80367; 80372; Opiate Confirmation, Qualitative, Urine ; Opiate Confirmation, Quantitative, Urine ; Opiate Confirmation, Quantitative, Urine ; Opiate Confirmation, Quantitative, Urine ; 80361; Opiate/Oxycodone, Serum, Screen (x2) Opiate/Oxycodone, Whole Blood Screen (x2) Opiates and Opioids, Serum/Plasma (x4); ; Opiates, Unconjugated Expanded, Serum/Plasma ; 80361; Opiates, Unconjugated Expanded, Whole Blood ; 80361; Orphenadrine (Norflex ) Oxazepam (Serax ), Serum Oxcarbazepine (Trileptal ) as Metabolite Oxycodone (Percodan ), Serum Forensic Oxycodone and Metabolite, Serum or Plasma Oxycodone and Metabolite, Whole Blood Oxycodone Confirmation, Quantitative, Urine Pain Clinic Drug Screen, Comprehensive, Whole Blood, With Reported Medications (x12); ; 80302; Paliperidone (Invega, 9-hydroxyrisperidone), Serum Paroxetine (Paxil ) Pemoline (Cylert ) Pentazocine (Talwin ), Serum Pentazocine (Talwin ), Urine-Forensic Pentobarbital (Nembutal ) Pentobarbital (Nembutal ), Serum Forensic Percocet (Acetaminophen and Oxycodone) ; ; Perphenazine (Trilafon ), Serum

9 Phencyclidine (PCP) Analysis, Serum Phencyclidine (PCP) Analysis, Whole Blood Phencyclidine (PCP) Confirmation, Serum Phenethylamines Phenethylamines and Benzylpiperazines Phenobarbital (Luminal ) Phenobarbital, Unbound Phenobarbital, Unbound and Total ; (x2) Phentermine Confirmation, Quantitative, Urine Phenylethylmalonamide (PEMA) Phenylpropanolamine Analysis, Urine Phenylpropanolamine Confirmation, Serum Phenytoin (Dilantin ) Phenytoin, Unbound Phenytoin, Unbound and Total ; ; Phosphatidylethanol Pregabalin (Lyrica ), Urine Pregabalin (Lyrica ) Primidone (Mysoline ) Primidone (Mysoline ) and Phenobarbital ; ; Prochlorperazine (Compazine ) Promethazine (Phenergan ) Propafenone (Rythmol ) Propoxyphene (Darvon ) and Norpropoxyphene, Serum Propoxyphene Analysis, Serum Propoxyphene Analysis, Whole Blood Propoxyphene Confirmation, Qualitative, Urine Propoxyphene Confirmation, Quantitative, Urine Propranolol (Inderal ) Protriptyline (Vivactyl ) Pseudoephedrine (Sudafed ), Serum Pseudoephedrine (Sudafed ), Urine Psilocin, Urine Psychoactive Drugs of Abuse, Qualitative/Quantitative, Urine Quetiapine (Seroquel ) Risperidone (Risperdal ) and 9-Hydroxyrisperidone Rodenticide (Anticoagulant) Screen Rufinamide (Banzel ) Salicylate Salvinorin A and B (Salvia), Urine Secobarbital (Seconal ) Secobarbital (Seconal ), Serum Forensic Sedative Hypnotic Profile, Urine Forensic (x2); 80101(x3); Sertraline (Zoloft ) and Desmethylsertraline ;

10 Solvent Inhalants Profile, Blood ; ; Sotalol (Betapace ) Sufentanil (Sufenta), Serum Sulfonylurea Screen, Quantitative, Serum or Plasma Sulfonylurea Screen, Urine Sympathomimetic Amine Confirmation, Qualitative, Urine Synthetic Cannabinoids (K2, Spice), Expanded Profile, Qualitative Synthetic Cannabinoids (K2, Spice), Expanded Profile, Quantitative Synthetic Cannabinoids, Confirmation Comprehensive Synthetic Cannabinoids, Scheduled Confirmation Synthetic Cannabinoids, Scheduled, Urine, Qualitative Synthetic Cannabinoids, Whole Blood Synthetic Designer Drug Profile (x2); 82542(x2) 80304(x2); Tapentadol and MTB, Urine Temazepam (Restoril ), Serum THC (Marijuana) Metabolite, Urine; Normalized to Creatinine Forensic ; ; THC (Tetrahydrocannabinol) Confirmation, Serum Theophylline (Theodur ) Theophylline, Unbound Thiopental (Pentothal ) and Pentobarbital Thioridazine (Mellaril ) and Mesoridazine Thiothixene (Navane ) Tiagabine (Gabitril ) Tissue Drug Screen (x15); 80100(x2) Topiramate (Topamax ) Tramadol (Ultram ) and 0-Desmethyltramadol, Urine Tramadol (Ultram ) and 0-Desmethyltramadol, Serum Tramadol (Ultram ), Urine Qualitative Tranylcypromine (Parnate ) Trazodone (Desyrel ) Triazolam (Halcion ) Triazolam Confirmation, Quantitative, Urine Trifluoperazine (Stelazine ) Trihexyphenidyl (Artane ), Serum Trimethadione (Tridione ) and Dimethadione Trimipramine (Surmontil ) Tylox (Acetaminophen and Oxycodone) ; ; Valproic Acid (Depakene ) Valproic Acid, Unbound Valproic Acid, Unbound and Total ; ; Vancomycin (Vancocin ) Venlafaxine (Effexor ) and Desmethylvenlafaxine Vigabatrin (Sabril ) Vitreous Fluid Screen ; 80101(x11);

11 Volatiles Screen Ziprasidone (Geodon, Zeldox ) Zolpidem (Ambien ), Serum or Plasma Zolpidem (Ambien ), Urine Zonisamide (Zonegran ) Test Name Test Nº CPT 2014 CPT 2015 Molecular Pathology Procedures Human Papillomavirus (HPV) 16/18 Only Human Papillomavirus (HPV) High-risk Human Papillomavirus (HPV) High-risk Screen Human Papillomavirus (HPV) High-risk With Genotyping Human Papillomavirus (HPV) Screen With Reflex to Genotyping Immunohistochemistry (IHC) Changes Test Name CPT 2014 CPT 2015 Initial single IHC antibody stain procedure, per specimen Each additional IHC antibody stain on a single specimen Each IHC multiplex antibody stain procedure (ie, multiplex antibody stain procedure) 88342; 88343* Morphometric analysis, tumor immunohistochemistry, quantitative or semiquantitative, each single antibody stain, manual, per specimen Morphometric analysis, tumor immunohistochemistry, quantitative or semiquantitative, each single antibody stain, computer-assisted technology, per specimen In Situ Hybridization (ISH) Changes Test Name CPT 2014 CPT 2015 In situ hybridization, initial single probe, per specimen Each additional single probe stain procedure Each multiplex probe stain procedure, per specimen (ie, multiplex probe stain procedure) 88365* Morphometric analysis, in situ hybridization, quantitative or semiquantitative, initial single probe stain procedure, manual, per specimen Each additional single probe stain procedure, per specimen Each separately identifiable probe applied to the same specimen (ie, multiplex probe stain procedure) 88368* *The number of units billed is dependent on the specific multiplex test that is performed Laboratory Corporation of America Holdings All Rights Reserved

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