Personal information. Academic positions. Teaching experience. Matteo Caffini. Curriculum Vitæ

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1 ACN Labs - CIMeC p.za Manifattura Rovereto (TN), Italy tel.: matteo.caffini@unitn.it skype: matteo.caffini Personal information Date of birth: August 24th, 1981 Place of birth: Mantova, Italy Citizenship: Italian Academic positions Mar now ACN Labs - CIMeC - University of Trento (Rovereto, Italy) Primary research activity: functional Near InfraRed Spectroscopy and scientific computing Nov Feb 2015 Dipartimento di Bioingegneria - Politecnico di Milano (Milano, Italy) Primary research activity: Molecular Imaging techniques and data analysis Visiting scientist at KU Leuven (Leuven, Belgium), Nov Jul 2014 Feb Oct Dipartimento di Scienze della Salute - Università degli Studi dell Aquila (L Aquila, Italy) Primary research activity: InfraRed Spectroscopy applied to biological tissues Dipartimento di Fisica - Politecnico di Milano (Milano, Italy) Primary research activity: InfraRed Spectroscopy applied to biological tissues Teaching experience Physics for graduates and undergraduates. Politecnico di Milano (Milano, Italy)

2 Education PhD in Physics Dipartimento di Fisica - Politecnico di Milano (Milano, Italy) Thesis: Diffuse Optical Tomography - Development and Validation of a Medical Device and of Physical Models for Brain Activation Studies Advisor: Prof. Rinaldo Cubeddu Visiting student at Massachusetts Institute of Technology (Cambridge, MA, USA) Visiting student at Martinos Center for Biomedical Imaging (Charlestown, MA, USA) Advisor: Prof. David A. Boas Period: Laurea magistrale in Biomedical Engineering Politecnico di Milano (Milano, Italy) Thesis: Functional NIRS techniques in a sustained attention test Laurea triennale in Biomedical Engineering Politecnico di Milano (Milano, Italy) Thesis: Functional Magnetic Resonance Imaging Diploma di maturità scientifica Istituto Tecnico Industriale Enrico Fermi (Mantova, Italy) Scholarships, Grants and Awards Best Student Poster Award at NIH Workshop 2011: 7th NIH Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside (Bethesda, MD, USA) Progetto Roberto Rocca scholarship (Boston, MA, USA) Ministero per l Università e la Ricerca scholarship (Milano, Italy) Computer skills O.S: MacOS X, Linux, Microsoft Windows Scientific computing and programming: Python, Matlab, C, C++ CAD: Blender, Solidworks, Rhinoceros, AutoCAD Others: L A TEX, Adobe Photoshop, Adobe Illustrator Technical skills Machine tools: excellent level Electrical tools: excellent level

3 Languages Italian: mother tongue English: excellent level French: good level Current Research interests Functional neuroimaging, Scientific Computing, Neuroscience Selected Publications Peer Reviewed Journals N. Bergsland, M. M. Laganà, E. Tavazzi, M. Caffini, P. Tortorella, F. Baglio, G. Baselli and M. Rovaris. Corticospinal tract integrity is related to primary motor cortex thinning in relapsing-remitting multiple sclerosis Multiple Sclerosis, 2015 Mar 19. [Epub ahead of print] M.M. Laganà and E. Tavazzi contributed equally to the paper. E. Visani, L.Canafoglia L, I. Gilioli, D. R. Sebastiano, V. E. Contarino, D. Duran, F. Panzica, R. Cubeddu, D. Contini, L. Zucchelli, L. Spinelli, M. Caffini, E. Molteni, A. M. Bianchi, S. Cerutti, S. Franceschetti, A. Torricelli. Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study. Brain Topography, 2014 Sep 25. [Epub ahead of print] H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, A. Torricelli. Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol. Journal of Biomedical Optics 2014 Aug;19(8): doi: /1.JBO A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, L. Spinelli. Time domain functional NIRS imaging for human brain mapping. Neuroimage, 2014 Jan 15; 85 Pt 1: doi: /j.neuroimage R. Re, M. Muthalib, D. Contini, L. Zucchelli, A. Torricelli, L. Spinelli, M. Caffini, M. Ferrari, V. Quaresima, S. Perrey, G. Kerr. Cerebral Cortex Activation Mapping upon Electrical Muscle Stimulation by 32-Channel Time-Domain Functional Near-Infrared Spectroscopy. Advances in Experimental Medicine and Biology, 789:441-7, R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, A. Torricelli. Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing. Biomedical Optics Express 2013 Sep 24;4(10): doi: /BOE V. Bari, P. Calcagnile, E. Molteni, R. Re, D. Contini, L. Spinelli, M. Caffini, A. Torricelli, R. Cubeddu, S. Cerutti, A. M. Bianchi. From neurovascular coupling to neurovascular cascade: a study on neural, autonomic and vascular transients in attention. Physiological Measurement, 33(8): , R. J. Cooper*, M. Caffini*, J. Dubb, A. Custo, D. Tsuzuki, B. Fischl, W. Wells III, I. Dan, D. A. Boas. Validating atlas-guided DOT: A comparison of diffuse optical tomography informed by atlas and subject-specific anatomies Neuroimage, 62(3), pagg , * These authors contributed equally to this paper. D. Contini, L. Zucchelli, L. Spinelli, M. Caffini, R. Re, A. Pifferi, R. Cubeddu and A. Torricelli. Brain and muscle near infrared spectroscopy/imaging techniques. Journal of Near Infrared Spectroscopy, 20, pagg , 2012.

4 E. Molteni, D. Contini, M. Caffini, G. Baselli, L. Spinelli, R. Cubeddu, S. Cerutti, A. M. Bianchi, S. Cerutti and A. Torricelli. Load-dependent brain activation assessed by time-domain functional near-infrared spectroscopy during a working memory task with graded levels of difficulty. Journal of Biomedical Optics, 17(5), , R. Re, D. Contini, M. Caffini, R. Cubeddu, L. Spinelli, and A. Torricelli. A compact timeresolved system for near infrared spectroscopy based on wavelength space multiplexing. Review of Scientific Instruments, 81, , M. Butti, D. Contini, E. Molteni, M. Caffini, L. Spinelli, G. Baselli, A. M. Bianchi, S. Cerutti, R. Cubeddu, and A. Torricelli. Effect of prolonged stimulation on cerebral hemodynamic: A time-resolved fnirs study. Medical Physics, 36(9): , Book Chapters M. Caffini, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu and A. Torricelli. Diffuse Optical Imaging of the Brain, in Dr. V. Chaudhary (editor), Brain Imaging. InTech Publisher, A. Torricelli, D. Contini, L. Spinelli, M. Caffini, A. Pifferi, and R. Cubeddu. Advanced methods for functional brain imaging, in N. Iftimia, W. R. Brugge, and D. X. Hammer (editors), Advances in Optical Imaging for Clinical Medicine, volume 1 of Wiley Series in Biomedical Imaging. Wiley, May Invited Talks M. Caffini, A. Torricelli, D. Contini, L. Zucchelli, R. Cubeddu, L. Spinelli, E. Molteni, A. M. Bianchi, G. Baselli, S. Cerutti, E. Visani, I. Gilioli, D. S. Sebastiano, E. Schiaffi, F. Panzica and S. Franceschetti. A multimodality approach based on fnirs-eeg, fmri-eeg and TMS for the assessment of cortical response during motor task in adults. 13 Convegno Nazionale delle Tecnologie Fotoniche. Genova, May 9-11, M. Caffini, D. Contini, L. Spinelli, R. Cubeddu, and A. Torricelli. A multichannel time-domain brain oximeter for clinical studies. 3rd Boston Workshop on Advanced TCSPC techniques. Boston, October 16, Proceedings of International Conferences L. Spinelli, A. Torricelli, D. Contini, M. Caffini, L. Zucchelli, R. Cubeddu, E. Molteni, A. M. Bianchi, G. Baselli, S. Cerutti, E. Visani, I. Gilioli, D. S. Sebastiano, E. Schiaffi, F. Panzica and S. Franceschetti. Multimodality fnirs-eeg, fmri-eeg and TMS Clinical Study on Cortical Response During Motor Task in Adult Volunteers and Epileptic Patients with Movement Disorders. Biomedical Optics. OSA, BM4A.1, V. Bari, P. Calcagnile, E. Molteni, R. Re, D. Contini, L. Spinelli, M. Caffini, A. Torricelli, R. Cubeddu, S. Cerutti, A. M. Bianchi. Study of neurovascular and autonomic response in a divided attention test by means of EEG, ECG and NIRS signals. Proceedings of 33rd International Conference of the IEEE EMBS, September 3, M. Caffini, L. Zucchelli, D. Contini, R. Cubeddu, L. Spinelli, D. Boas and A. Torricelli. Anatomical brain atlas for NIRS measurements of brain activation. Proc. ECBO 2011, NMTB, pag A. Torricelli, D. Contini, M. Caffini, L. Zucchelli, R. Cubeddu, L. Spinelli, E. Molteni, A. M. Bianchi, G. Baselli, S. Cerutti, E. Visani, I. Gilioli, D. S. Sebastiano, E. Schiaffi, F. Panzica and S. Franceschetti. Assessment of cortical response during motor task in adults by a multimodality approach based on fnirs-eeg, fmri-eeg, and TMS. Proc. ECBO 2011, MBF, pag H. Wabnitz, A. Pifferi, A. Torricelli, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, P. Sawosz, A. Liebert, R. Macdonald, and R. Cubeddu. Assessment of basic instrumental performance of time-domain optical brain imagers. Proc. SPIE 7896, , 2011.

5 M. Caffini, A. Torricelli, R. Cubeddu, A. Custo, J. Dubb, and D. Boas. Validating an Anatomical Brain Atlas for Analyzing NIRS Measurements of Brain Activation. Biomedical Optics, OSA Technical Digest (CD), (Optical Society of America, 2010), paper JMA87. D. Contini, E. Molteni, R. Re, M. Caffini, A. Bianchi, L. Spinelli, G. Baselli, S. Cerutti, R. Cubeddu, and A. Torricelli. EEG and Time-Domain fnirs Co-Registration during a Divided Attention Task. Biomedical Optics, OSA Technical Digest (CD), (Optical Society of America, 2010), paper BSuD72. D. Contini, L. Spinelli, M. Caffini, L. Zucchelli, A. Tosi, R. Cubeddu, and A. Torricelli. A Multichannel Medical Device for Brain Imaging by Time-Domain fnirs. Biomedical Optics, OSA Technical Digest (CD), (Optical Society of America, 2010), paper JMA101. M. Caffini, A. Torricelli, R. Cubeddu, A. Custo, J. Dubb, and D. Boas. Validating an Anatomical Brain Atlas for Analyzing NIRS Measurements of Brain Activation. Digital Holography and Three-Dimensional Imaging, OSA Technical Digest (CD), (Optical Society of America, 2010), paper JMA87. D. Contini, L. Spinelli, M. Caffini, L. Zucchelli, A. Tosi, R. Cubeddu, and A. Torricelli. A Multichannel Medical Device for Brain Imaging by Time-Domain fnirs. Digital Holography and Three-Dimensional Imaging, OSA Technical Digest (CD), (Optical Society of America, 2010), paper JMA101. D. Contini, L. Spinelli, M. Caffini, R. Cubeddu, and A. Torricelli. A multichannel time-domain brain oximeter for clinical studies. Volume 7369, Page 73691D. SPIE, E. Molteni, G. Baselli, A. M. Bianchi, M. Caffini, D. Contini, L. Spinelli, A. Torricelli, S. Cerutti, and R. Cubeddu. Frontal brain activation during a working memory task: a time-domain fnirs study. Volume 7161, Page 71613N. SPIE, E. Molteni, A. M. Bianchi, G. Baselli, M. Caffini, D. Contini, L. Spinelli, A. Torricelli, S. Cerutti, and R. Cubeddu. Intra- and extra-cortical activation during a working memory task assessed by time-resolved near-infrared spectroscopy (fnirs). Volume 7369, Page SPIE, R. Re, D. Contini, M. Caffini, L. Spinelli, R. Cubeddu, and A. Torricelli. A compact timeresolved system for NIR spectroscopy. Volume 7368, Page SPIE, D. Contini, A. Torricelli, L. Spinelli, A. Pifferi, M. Caffini, and R. Cubeddu. time-resolved system for functional near infrared spectroscopy of brain cortex. Elettroottica, Milano, Giugno Multi-channel In Proceedings M. Butti, G. Baselli, A. M. Bianchi, M. Caffini, D. Contini, L. Spinelli, A. Torricelli, S. Cerutti, and R. Cubeddu. Generalized linear models to interpret time domain nirs: Effect of a prolonged stimulation on cerebral hemodynamics. In Biomedical Optics, page BMD10. Optical Society of America, A. Torricelli, D. Contini, L. Spinelli, M. Caffini, M. Butti, G. Baselli, A. M. Bianchi, A. Bardoni, S. Cerutti, and R. Cubeddu. Continuous Performance Test assessed with time-domain functional near infrared spectroscopy. Volume 6629, Page 66291M. SPIE, M. Butti, M. Caffini, A. Merzagora, A. Bianchi, G. Baselli, B. Onaral, P. Secchi, and S. Cerutti. Non-invasive neuroimaging: Generalized linear models for interpreting functional near infrared spectroscopy signals. In Neural Engineering, CNE 07. 3rd International IEEE/EMBS Conference on, Pages , May Other Istruttore di Arrampicata Libera (IAL) at Club Alpino Italiano (CAI). General Interests Free-climbing, mountaineering, football, hiking, music, literature.

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