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TABLE OF CONTENTS 1. The US Orthopedic Implants and Devices Market Introduction 2. The US Orthopedic Implants and Devices Market Value Chain 3. The US Orthopedic Implants and Devices Market Size, 2008-2013 4. The US Orthopedic Implants and Devices Market Segmentation, 2008-2013 5. The US Reconstructive Joint Replacement Implants Market Introduction and Market Size, 2008-2013 6. The US Reconstructive Joint Replacement Implants Market Segmentation by Hips, Knee, Shoulders and Others, 2008-2013 7. The US Hip Implants Market Introduction 7.1. The US Hip Implants Market Size by Value, 2008-2013 8. The US Hip Implants Market Segmentation, 2008-2013 8.1. By Type of Hip Replacement Procedure, 2011 and 2013 8.2. By Type of Components, 2010 and 2013 9. Market Shares of the Major Players in the US Hip Implant Market, 2009, 2010 and 2013 10. Future Outlook and Projections of the US Hip Implants Market, 2014-2018 11. The US Knee Implants Market Introduction 11.1. The US Knee Implants Market Size by Value, 2008-2013 12. The US Knee Implants Market Segmentation, 2008-2013 12.1. By Type of Knee Replacement Procedure, 2008 and 2013 12.2. By Type of Components, 2010 and 2013 13. Market Shares of the Major Players in the US Knee Implant Market, 2009, 2010 and 2013 14. Future Outlook and Projections of the US Knee Implants Market, 2014-2018 15. Trends and Developments in the US Hip and Knee Implants Market Minimally Invasive Hip and Knee Replacement Surgeries Gaining Traction Consolidation of the Orthopedic Devices Market Specialized and Custom Fitted Hip Implants

Rise in the Readmissions of the Hip Replacement Patients with Shorter Stays in Hospitals Post-surgery Manufacturers Focusing on Customized and Personalized Knee Implants Growing Demnad for Gender-specific Knee Implants Increasing Adoption of Computer Assisted Surgery Recall of Metal-on-Metal Hip Replacement Implants Growing Knee Replacement Lawsuits and Recall of Knee Implants Other Emerging Trends in the US Orthopedic Implants Market 16. Government Regulations in the US Orthopedic Implants and Devices Market 17. Company Profiles of the Major Players 18. SWOT Analysis of the US Orthopedic Implants Industry Strengths Weaknesses Opportunities Threats 19. Porter s Five Forces Analysis of the US Orthopedic Implants and Devices Market Bargaining Power of Buyers Bargaining Power of Suppliers Threat of New Entrants Threat of New Substitute Products Rivalry between Competitors 20. Future Outlook and Projections of the US Orthopedic Implants and Devices Market, 2014-2018 21. Macro-economic and Industry Factors Historical and Projections 21.1. Total and Old Population in the US, 2008-2018 21.2. Obese and Overweight Population in the US, 2008-2018 21.3. Personal Disposable Income of the Population in the US, 2008-2018

21.4. Total Healthcare Expenditure in the US, 2008-2018 21.5. Total Health Insurance Premiums Underwritten, 2008-2018 21.6. Total Diagnosed Diabetic Population in the US, 2008-2018 22. Appendix 22.1. Market Definitions 22.2. Abbreviations 22.3. Research Methodology Data Collection Methods Approach Variables (Dependent and Independent) Multi Factor Based Sensitivity Model Final Conclusion 22.4. Disclaimer

LIST OF FIGURES Figure 1: The Orthopedic Implants and Devices Value Chain Figure 2: The US Orthopedic Implants and Devices Market Size by Value on the Basis of Revenues in USD Million, 2008-2013 Figure 3: The US Reconstructive Joint Replacement Implants Market Size by Value on the Basis of Revenues in USD Million, 2008-2013 Figure 4: The US Reconstructive Joint Replacement Implants Market Segmentation by Knee, Hip, Shoulder and Other Implants on the Basis of Revenue in Percentage, 2008-2013 Figure 5: Hip Implant Components Figure 6: The US Hip Implants Market Size by Value on the Basis of Revenues in USD Million, 2008-2013 Figure 7: The US Hip Implant Market Segmentation by Type of Hip Replacement Procedure on the Basis of Revenue in Percentage, 2011 and 2013 Figure 8: The US Hip Implant Market Segmentation by Type of Components on the Basis of Revenue in Percentage, 2010 and 2013P Figure 9: The US Hip Stem Market Segmentation by Coated, Uncoated, Long and Resurfacing on the Basis of Revenue in Percentage, 2010 and 2013P Figure 10: The US Hip Implants Market Future Projections by Value on the Basis of Revenues in USD Million, 2014-2017 Figure 11: Knee Implant Components Figure 12: The US Knee Implants Market Size by Value on the Basis of Revenues in USD Million, 2008-2013 Figure 13: The US Knee Implant Market Segmentation by Type of Knee Replacement Procedure on the Basis of Revenue in Percentage, 2008 and 2013 Figure 14: The US Knee Implant Market Segmentation by Type of Components on the Basis of Revenue in Percentage, 2010 and 2013P Figure 15: The US Knee Implants Market Future Projections by Value on the Basis of Revenues in USD Million, 2014-2018 Figure 16: The US Orthopedic Implants and Devices Market Future Projections by Value on the Basis of Revenues in USD Million, 2014-2018 Figure 17: Total and Old Population in the US in Million, 2008-2018

Figure 18: Total Obese and Overweight Population in the US in Million, 2008-2018 Figure 19: Personal Disposable Income of the Population in the US in USD Million, 2008-2018 Figure 20: Total Healthcare Expenditure in the US in USD Million, 2008-2018 Figure 21: Total Health Insurance Premiums Underwritten in the US in USD Million, 2008-2018 Figure 22: Total Diagnosed Diabetic Population in the US in Million, 2008-2018

LIST OF TABLES Table 1: The US Orthopedic Implants and Devices Market Segmentation by Implants and Devices on the Basis of Revenue in Percentage, 2008-2013 Table 2: The US Orthopedic Implants and Devices Market Segmentation by Implants and Devices on the Basis of Revenue in USD Million, 2008-2013 Table 3: The US Orthopedic Implants Market Segmentation by Type of Implants on the Basis of Revenue in Percentage, 2008-2013 Table 4: The US Orthopedic Implants Market Segmentation by Type of Implants on the Basis of Revenue in USD Million, 2008-2013 Table 5: Market Share of the Major Players in the US Hip and Knee Implant Market on the Basis of Revenue in Percentage, 2009, 2010 and 2013P Table 6: Revenues of the Major Players in the US Hip and Knee Implant Market in USD Million, 2009, 2010 and 2013P Table 7: The US Reconstructive Joint Replacement Implants Market Segmentation by Knee, Hip, Shoulder and Other Implants on the Basis of Revenue in USD Million, 2008-2013 Table 8: The US Reconstructive Joint Replacement Implants Market Segmentation and Projections by Knee, Hip, Shoulder and Other Implants on the Basis of Revenue in USD Million, 2014-2018 Table 9: The US Hip Implant Market Segmentation by Type of Hip Replacement Procedure on the Basis of Revenue in USD Million, 2011 and 2013 Table 10: The US Hip Implant Market Segmentation by Type of Components on the Basis of Revenue in USD Million, 2010 and 2013P Table 11: The US Hip Stem Market Segmentation by Coated, Uncoated, Long and Resurfacing on the Basis of Revenue in USD Million, 2010 and 2013P Table 12: Market Share of the Major Players in the US Hip Implant Market on the Basis of Revenue in Percentage, 2009, 2010 and 2013P Table 13: Revenues of the Major Players in the US Hip Implant Market in USD Million, 2009, 2010 and 2013P Table 14: The US Knee Implant Market Segmentation by Type of Knee Replacement Procedure on the Basis of Revenue in USD Million, 2008 and 2013 Table 15: The US Knee Implant Market Segmentation by Type of Component on the Basis of Revenue in Percentage, 2010 and 2013P

Table 16: Market Share of the Major Players in the US Knee Implant Market on the Basis of Revenue in Percentage, 2009, 2010 and 2013P Table 17: Revenues of the Major Players in the US Knee Implant Market in USD Million, 2009, 2010 and 2013P Table 18: Company Profiles of the Major Players present in the US Hip and Knee Implant Market Table 19: Financial Performance of the Major Players present in the US Orthopedic Equipment Market in USD Million, 2008-2012 Table 20: Financial Performance of Biomet Inc. in USD Million, 2011-2013 Table 21: The US Orthopedic Implants and Devices Market Segmentation and Projections by Implants and Devices on the Basis of Revenue in USD Million, 2014-2018 Table 22: The US Orthopedic Implants Market Segmentation and Projections by Type of Implants on the Basis of Revenue in Percentage, 2014-2018 Table 23: Correlation Matrix for the US Hip Implants Market Table 24: Regression Coefficients Output

THE US ORTHOPEDIC IMPLANTS AND DEVICES MARKET SIZE, 2008-2013 device manufacturers have leveraged their position in the market to steadily increase the prices while the reimbursement rates of the US government have stagnated or declined. The overall orthopedic implants and devices market in the US has expanded at a CAGR of ~% during 2008-2013 to reach USD ~ million in 2013 from around USD ~ million in 2008. Figure: The US Orthopedic Implants and Devices Market Size by Value on the Basis of Revenues in USD Million, 2008-2013 30,000.0 25,000.0 USD Million 20,000.0 15,000.0 10,000.0 5,000.0 0.0 2008 2009 2010 2011 2012 2013 THE US ORTHOPEDIC IMPLANTS AND DEVICES MARKET SEGMENTATION, 2008-2013 the orthopedic implants market of the US can also be segmented into seven major segments which include implants used in reconstructive joint replacements, spinal implants, trauma implants, orthobiologics, bone cement and accessories, extremity implants and others. Reconstructive joint replacement implants are the largest segment and represented around ~% of

the revenues generated in the US orthopedic implants market in 2013. These implants largely comprise of knee, hip and shoulder implants Table: The US Orthopedic Implants Market Segmentation by Type of Implants on the Basis of Revenue in Percentage, 2008-2013 Implant Segment 2008 2009 2010 2011 2012 2013 Reconstructive Joint Replacements Spinal Implants Trauma Implants Orthobiologics Bone Cement and Accessories Extremities Others Table: The US Orthopedic Implants Market Segmentation by Type of Implants on the Basis of Revenue in USD Million, 2008-2013 Implant Segment 2008 2009 2010 2011 2012 2013 Reconstructive Joint Replacements Spinal Implants Trauma Implants Orthobiologics Bone Cement and Accessories Extremities Others Total

THE US RECONSTRUCTIVE JOINT REPLACEMENT IMPLANTS MARKET SEGMENTATION BY HIPS, KNEE, SHOULDERS AND OTHERS, 2008-2013 The reconstructive joint replacement implant market in the US can be segmented into knee, hip, shoulder and others on the basis of the use of implant and the site of the repair. Knee implants was the largest segment with a share of ~% in terms of revenue in 2013. While the contribution of the segment has largely remained unchanged over the years, the revenues from the sales of knee implants have increased from around USD ~ million in 2008 to USD ~ million in 2013 Figure: The US Reconstructive Joint Replacement Implants Market Segmentation by Knee, Hip, Shoulder and Other Implants on the Basis of Revenue in Percentage, 2008-2013 100.0% 90.0% Percentage 80.0% 70.0% 60.0% 50.0% 40.0% 2008 2009 2010 2011 2012 2013 Knees Hips Shoulders Others Table: The US Reconstructive Joint Replacement Implants Market Segmentation by Knee, Hip, Shoulder and Other Implants on the Basis of Revenue in USD Million, 2008-2013 Implant Segment 2008 2009 2010 2011 2012 2013 Knees

Hips Shoulders Others Total THE US HIP IMPLANTS MARKET SEGMENTATION, 2008-2013 BY TYPE OF COMPONENTS, 2010 AND 2013 On the basis of the type of components, the hip implant market of the US can segmented into stem, shell/liner, head and others. Stem is the largest segment with a share of around ~% in the overall hip implant market of the US in 2013. The segment generated revenue of USD ~ million in 2013, inclining from USD ~ million in 2010. The high share of stem in the hip implant market of the US has majorly resulted from the large number of total hip replacement (THR) procedures performed in the country Figure: The US Hip Implant Market Segmentation by Type of Components on the Basis of Revenue in Percentage, 2010 and 2013P 100.0% 90.0% 80.0% 70.0% 60.0% Percentage 50.0% 40.0% 30.0% 20.0% 10.0% 0.0% 2010 2013 Stem Shell/Liner Head Other

Table: The US Hip Implant Market Segmentation by Type of Components on the Basis of Revenue in USD Million, 2010 and 2013P Hip Implant Component 2010 2013P Stem Shell/Liner Head Other MARKET SHARES OF THE MAJOR PLAYERS IN THE US HIP IMPLANT MARKET, 2009, 2010 AND 2013 The hip implants market of the US is dominated by six leading players which account for over 90.0% of the market in terms of sales revenue. These companies include DePuy Synthes, Stryker, Zimmer, Biomet, Wright and Exactech. DePuy Synthes which is owned by Johnson & Johnson is the largest player with a market share of ~% in the domestic sales of hip implants by value in the US in 2013 Table: Market Shares of the Major Players in the US Hip Implant Market on the Basis of Revenue in Percentage, 2009, 2010 and 2013P Company 2009 2010 2013P DePuy Stryker Zimmer Synthes Biomet Wright Exactech Others

Table: Revenues of the Major Players in the US Hip Implant Market in USD Million, 2009, 2010 and 2013P Company 2009 2010 2013P DePuy Stryker Zimmer Synthes Biomet Wright Exactech Others THE US KNEE IMPLANTS MARKET SEGMENTATION, 2008-2013 BY TYPE OF COMPONENTS, 2010 AND 2013 Knee implants can also be segmented on the basis of various components which are used as implants while performing knee replacement surgeries. On the basis of the types of components the knee implants can be categorized into Bicondylar femurs, tibia, tibial inserts, Patellas, unicondylar knees and others which include stems, wedges and hinged knees. Bicondylar femurs are the largest segment and accounted for around ~% of the knee implant market in terms of sales revenues in 2013. Around USD ~ million worth of Bicondylar femurs were sold in the US in 2013

Figure: The US Knee Implant Market Segmentation by Type of Components on the Basis of Revenue in Percentage, 2010 and 2013P 100.0% 90.0% 80.0% 70.0% Percentage 60.0% 50.0% 40.0% 30.0% 20.0% 10.0% 0.0% 2010 2013P Bicondylar Femurs Tibial Inserts Unicondylar Knees Tibia Patellas Others (stems, wedges, hinged knees) Table: The US Knee Implant Market Segmentation by Type of Component on the Basis of Revenue in Percentage, 2010 and 2013P Knee Implant Component 2010 2013P Bicondylar Femurs Tibia Tibial Inserts Patellas Unicondylar Knees Others (stems, wedges, hinged knees) Total

MARKET SHARES OF THE MAJOR PLAYERS IN THE US KNEE IMPLANT MARKET, 2009, 2010 AND 2013 The knee implant market in the US has primarily been dominated by six large implant manufacturing companies over the past few years. These companies together represent more than 90.0% of the knee implant sales in the US in terms of value. Presently DePuy Synthes is the largest player and has a market share of around ~%. DePuy acquired Synthes in 2012 and independently it had a share of around ~% and ~% in 2009 and 2010 respectively Table: Market Shares of the Major Players in the US Knee Implant Market on the Basis of Revenue in Percentage, 2009, 2010 and 2013P Company 2009 2010 2013P DePuy Zimmer Stryker Biomet Synthes Wright Exactech Other Table: Revenues of the Major Players in the US Knee Implant Market in USD Million, 2009, 2010 and 2013P Company 2009 2010 2013P DePuy Zimmer Stryker Biomet Synthes Wright Exactech Others

FUTURE OUTLOOK AND PROJECTIONS OF THE US ORTHOPEDIC IMPLANTS AND DEVICES MARKET, 2014-2018 It was estimated that mean annual caseload per surgeon would be around 52 surgeries annually by 2010; while by 2030 the annual caseload per surgeon was anticipated would triple to 167. The overall orthopedic implants and devices market of the US is projected to surge to around USD ~ million in 2018 from USD ~ million in 2013 by expanding at a CAGR of ~% during the forecast period of 2013-2018. In 2014 the market is estimated to reach USD ~ million by experiencing an annual growth of ~% over 2013. Figure: The US Orthopedic Implants and Devices Market Future Projections by Value on the Basis of Revenues in USD Million, 2014-2018 USD Million 35,000.0 34,000.0 33,000.0 32,000.0 31,000.0 30,000.0 29,000.0 28,000.0 27,000.0 26,000.0 2014 2015 2016 2017 2018 Table: The US Orthopedic Implants and Devices Market Segmentation and Projections by Implants and Devices on the Basis of Revenue in USD Million, 2014-2018 Implant Segment 2014 2015 2016 2017 2018 Implants

Equipments/Devices Total Table: The US Orthopedic Implants Market Segmentation and Projections by Type of Implants on the Basis of Revenue in Percentage, 2014-2018 Implant Segment 2014 2015 2016 2017 2018 Reconstructive Joint Replacements Spinal Implants Trauma Implants Orthobiologics Bone Cement and Accessories Extremities Others Total

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