Proton Therapy Essentials



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Proton Therapy Essentials An Architect s Perspective Presented By: Tsoi/Kobus & Associates Architects: Erik Mollo-Christensen, AIA Principal Jonathan Cohen, AIA Associate Principal

Proton Therapy Essentials An Architect s Perspective Objectives: 1. Overview What is Proton Therapy? Advantages Demand/Availability Opportunities/Challenges 2. Anatomy of a PT Facility Physical requirements Design flexibility A Healing Environment Planning considerations

Introduction Tsoi/Kobus & Associates (TK&A) offers nearly 20 years of experience in proton therapy facility planning and design Experience with: Cancer Centers Operating proton therapy facilities Planned proton therapy facilities Proton equipment manufacturers Academic and private proton therapy facilities Erik Mollo-Christensen, Principal Building long-term relationships 3-D modeling and design Jonathan Cohen, Associate Principal

1. Overview What is Proton Therapy? Advantages Demand/Availability Opportunities/Challenges

What is Proton Therapy? Form of radiation treatment using protons Large and specialized equipment Multi-room facilities 50-90,000 FT 2 $120-200 MM project cost Complex and integrated processes Finance Design/construction Physics Medicine

What is Proton Therapy? Form of radiation treatment using protons Large and specialized equipment Multi-room facilities 50-90,000 FT 2 $120-200 MM project cost Complex and integrated processes Finance Design/construction Physics Medicine Cyclotron accelerator Synchrotron accelerator

Clinical Advantages Higher dose with greater precision (tissue sparing) Reduced morbidity / side-effects Demonstrated effectiveness on cancer of the eye, head, neck, CNS, prostate, pediatric cancers Protons release their energy in a narrowly defined range Procure Treatment Center, Oklahoma City

Perceived Demand for Proton Therapy Significant and unmet need for Protons Especially for children Clinical role for PT remains controversial

Perceived Demand for Proton Therapy Significant and unmet need for Protons Especially for children Clinical role for PT remains controversial

Current Availability for Proton Therapy 1991 Loma Linda (U.S.) 2011 9 operating centers 4 under/construction +/- 25 centers worldwide Access remains limited (+/- 50,000 patients treated world-wide) Many centers announced/few built

Challenges to Adoption Financial/Regulatory High first cost/operating cost Financing CMS/Reimbursement coverage rate Political environment/healthcare reform

Challenges to Adoption Technical Limited Vendors/FDA and CE approval Equipment/Software not mature End user responsible for integration

Challenges to Adoption Clinical Slow facility ramp-up (not meeting business plan targets) Reliance on low-risk prostate cases Limited evidencephysician skepticism Lack of trained staff Clinicians Physicists Dosimetrists Radiation therapists

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule Still River Systems Monarch 250

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule IBA Proteus Nano

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule Compact Synchrotron, ProTom International

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) - 39 months Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) - 30 months Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

2. Anatomy of a PT Facility Physical Requirements Design Flexibility A Healing Environment Planning Considerations

What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities CT Exam

What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities

What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities Gantry ~ 90-190 tons

What are the Physical requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities

What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities

Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal

Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Integrated Facility

Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Free standing facility

Designing for Flexibility Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Proton Perelman Center for Advanced Medicine

Designing for Flexibility Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Cyclotron installation Gantry cage removal

A Healing Environment Self-referred patient base Outpatient treatment Efficiency/Throughout Two recent examples: - ProCure Treatment Center Oklahoma City, OK - Roberts Proton Therapy Center Philadelphia, PA

A Healing Environment Procure Treatment Center, Oklahoma City, OK

A Healing Environment

A Healing Environment

A Healing Environment

A Healing Environment

A Healing Environment Roberts Proton Therapy Center, Philadelphia, PA Raphael Vińoly Architects Perkins Eastman Tsoi/Kobus & Associates

A Healing Environment

A Healing Environment

A Healing Environment

A Healing Environment

Planning Considerations Clinical model/program Business model Site selection Team selection Equipment vendor Radiation physicist A/E team Builder Experience counts!