TILDELING AV FORSKNINGSMIDLER 2015



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TILDELING AV FORSKNINGSMIDLER 2015 Søker Prosjekttittel Institusjon Innvilget Beløp Magnar Bjørås Molykære mekansimer for DNA reparasjon Arne Klungland Characterization of novel and known DNA modifications in cancer initiation and progression Generelle driftsmidler 450 000 Bjarne Bogen T celler i immunovervåkning og immunterapi av kreft Generelle driftsmidler 175 000 Jorrit Enserink PRECISION MEDICINE FOR ACUTE MYELOID LEUKEMIA PATIENTS Alexandre Corthay Cancer immunotherapy by targeting tumor-infiltrating macrophages Generelle driftsmidler 169 000 Ole Audun Werner Haabeth Stig Ove Bøe Immunotherapeutic modulation of the bone marrow microenvironment in multiple myeloma Acute promyelocytic leukemia: molecular pathogenesis and mechanism of cure Kvalifiseringsstipend (3 år) 2 816 902 Generelle driftsmidler 175 000 Ingrun Alseth RNA modifications in cancer; the role of Endonuclease V Generelle driftsmidler 200 000 Kyrre Emblem TREATMENT - Improved Therapy Response Assessment in Metastatic Brain Tumors Eirik Malinen Image-based targeting of cancer

Cecilie Kiserud Alexander Fosså Hodgkin`s lymphoma: Risk and prevalence of long-term adverse effects and challenges for the health care service Euronet-PHL-C2 studien-en europeisk randomisert studie for optimalisert behandling av barn og unge med klassisk Hodgkin lymfom Generelle driftsmidler 175 000 Odd Terje Brustugun Precision oncology in lung cancer Generelle driftsmidler 175 000 Odd Terje Brustugun Novel EGFR-targeting therapy in non-small cell lung cancer. Treatment effects and resistance mechanisms. Klinisk korttidsstipend 942 000 Åslaug Helland Why are some cancers more aggressive? Generelle driftsmidler 175 000 Torgeir Bruun Wyller Kjersti Bruheim Treatment and survival in Norwegian cancer patients beyond 75 years of age Is the new concept of patient tailored radiotherapy safe in small cervical tumours? Klinisk korttidsstipend 942 000 Stein Andersson Executive functioning in survivors of pediatric brain tumors Generelle driftsmidler 100 000 Harald Stenmark Cell division and cancer Generelle driftsmidler 800 000 Camilla Raiborg ER-Endosome Contact: Implications for Tumour Suppressor Pathways, Cell Migration and Invasion Kaisa Haglund Cytokinesis and carcinogenesis Forskerstipend, 1-4. år 3 923 835 Generelle driftsmidler 100 000 Kay Oliver Schink Macropinocytosis in cancer cells - Culprit or Saviour? Kvalifiseringsstipend (3 år) 2 816 902 Sebastian Schultz Final steps of autophagosome closure - mechanistic insights and potential role in cancer Kvalifiseringsstipend (3 år) 2 816 902 Kirsten Sandvig Endocytosis and intracellular sorting of protein toxins

Alicia Llorente Sascha Pust Antoni Wiedlocha Extracellular Vesicles and Prostate Cancer: In Search of Tumorigenesis Mechanisms and Biomarkers Membrane crosslinkers in carcinogenesis: New possibilities for cancer diagnosis and therapy Next generation targeted radionuclide therapy for FGF receptor expressing cancers Generelle driftsmidler 175 000 Kvalifiseringsstipend (3 år) 2 816 902 Generelle driftsmidler 175 000 Jørgen Wesche Novel regulators of cancer cell migration Generelle driftsmidler 130 000 Ellen Margrethe Haugsten Ragnhild Lothe Switching off Met signalling - Identification of novel regulators and their relevance in metastatic prostate cancer Kreft, et resultat av genetiske og epigenetiske endringer. Modeller og mekanismer. Kvalifiseringsstipend (3 år) 2 816 902 Generelle driftsmidler 200 000 Guro Elisabeth Lind Epigenetic biomarkers for early detection and monitoring of cancer Generelle driftsmidler 175 000 Rolf Skotheim Kvalitativ transkriptvariasjon i kreft Heidi Lyng Molecular biomarkers in radiotherapy of cancer Anette Weyergang AN IMMUNE-MEDIATED GATEWAY FOR ELIMINATION OF CANCER Kvalifiseringsstipend (3 år) 2 816 902 Generelle driftsmidler 200 000 Einar Rofstad Tumor-Radiobiologi Generelle driftsmidler 175 000 Kristian Berg Fotokjemisk internalisering Generelle driftsmidler 175 000 Randi Syljuåsen DNA damage checkpoint signaling, hypoxia and radiation Generelle driftsmidler 175 000 Kristin Taskén Targeting therapy resistance in prostate cancer Generelle driftsmidler 175 000

Leonardo A Meza Zepeda Genome-wide genetic and epigenetic programs in cancer Generelle driftsmidler 175 000 Ola Myklebost Mesenchymal Cancer Medicine Generelle driftsmidler 800 000 Gunhild Mælandsmo Kjetil Boye Therapeutic approaches and molecular understanding of metastatic cancer Circulating tumor DNA as a biomarker in gastrointestinal stromal tumor Generelle driftsmidler 175 000 Kjersti Flatmark Colorectal cancer metastasis - a question of location Generelle driftsmidler 200 000 Øystein Fodstad Tumor-og molekylærbiologiske studier av metastaser. Utvikling av nye diagnostiske og terapeutiske metoder Generelle driftsmidler 175 000 Trevor Clancy Systems immunology to guide personalized cancer medicine Kvalifiseringsstipend (3 år) 2 816 902 Erlend Bremertun Smeland Kanutte Huse Biology of B cell lymphoma - identification of new diagnostic markers and targets for therapeutic intervention Deep profiling of tumor-cell heterogeneity and tumor-associated T cells in follicular lymphoma Kvalifiseringsstipend (3 år) 2 816 902 Johanna Olweus Genetically engineered T cells targeting cancer stem cells Generelle driftsmidler 600 000 Arne Kolstad Development of novel immunotherapies in malignant lymphoma - discovery of targets and T cell receptors Forskerstipend, 1-4. år 2 011 919 Karl-Johan Malmberg Development of Cell Therapies for Malignant Lymphomas Based on New Insights Into Natural Killer Cell Repertoire Diversity Generelle driftsmidler 385 000 Mouldy Sioud Sébastien Wälchli Improving Dendritic Cell Cancer Vaccine and Antibody Therapy: From Bench to Bedside DEVELOPMENT OF NOVEL STRATEGIES IN CANCER IMMUNOTHERAPY Generelle driftsmidler 175 000

June Myklebust Deciphering impact of genetic and proteomic alternations on drug sensitivity in B-cell lymphoma Generelle driftsmidler 350 000 Harald Holte Novel clinical and translational aspects of malignant B-cell lymphomas Forskerstipend, 1-4. år 2 011 919 Anders Tveita Immunotherapeutic targeting of tumor-associated macrophages Generelle driftsmidler 200 000 Hege Elisabeth Giercksky Russnes Intra tumor heterogeneity; from single cell analysis to diagnostic tools. Therese Sørlie Molecular portraits of breast cancer: Translating genomics to the clinical practice Generelle driftsmidler 175 000 Bjørn Naume Targeting occult tumor cell dissemination in localized breast cancer Vessela Kristensen The genetic Make-up and metabolic profile of breast cancer patients; relation to clinical course and treatment response Generelle driftsmidler 650 000 Kathrine Røe Redalen BioPicture - Biologic mapping for treatment individualisation in rectal cancer by functional magnetic resonance Kvalifiseringsstipend (3 år) 2 816 902 Anne Ree Efficacy and Tolerability to Targeted Combined-Modality Therapy -- Biological Mechanisms in Colorectal Cancer Anne Eskild Are women getting older at last menstrual period, and what may be causes and consequences of high age at menopause? Hilde Nilsen Functional implications of the RNA- and DNA-processing activity of SMUG1 in telomere maintenance, stem cells, and cancer Generelle driftsmidler 700 000 Hoa Thi Tuyet Tran Acute myeloid leukemia in the elderly Klinisk korttidsstipend 942 000