NAME: Cynthia CALKIN POSITION / TITLE: Assistant Professor of Psychiatry, Dalhousie University ADDRESS: Abbie J. Lane Building, Room 3095 5909 Veterans Memorial Lane Halifax, Nova Scotia B3H 2E2 Office: (902) 473-1126 Fax: (902) 473-4877 Email: cindy.calkin@cdha.nshealth.ca EDUCATION / TRAINING 2010-2010 Diploma - Statistical Genetics: Probability and Statistical Inference - University of Washington 2010-2010 Diploma - The Peer Review Process & Making Your Grant More Competitive - Dalhousie University 2005-2009 FRCPC - Fellow - Psychiatry, Dalhousie University 1993-1995 CCFP - Fellow - Family Practice - Dalhousie University 1989-1993 Doctorate (M.D.) - Dalhousie University 1987-1989 BSc (cum laude) - Dalhousie University USER PROFILE Disciplines Trained In: Psychiatry, Family Medicine Research Disciplines: Psychiatry Areas of Research: Mood Disorders, Neuroendocrine Diseases Fields of Application: Biomedical Aspects of Human Health, Pathogenesis and Treatment of Diseases Research Specialization Keywords: Bipolar Disorder, Medical Co-morbidity, Metabolic Syndrome, Psychiatry, Type 2 Diabetes
POSITIONS AND HONOURS Positions and Employment 2010 - present Active staff psychiatrist, Capital District Health Authority, Halifax, Nova Scotia, Canada 2012 - present Assistant Professor, Department of Psychiatry, Dalhousie University 2010 2012 Lecturer, Department of Psychiatry, Dalhousie University Honors 1999-2002 APA Physician s Recognition Award (Distinction) - American Medical Association 1992 Dr. Elizabeth Weld Memorial Award (Distinction) - Dalhousie University 1991 John George & Emily MacDougall Award (Distinction) - Dalhousie University 1990 John George & Emily MacDougall Award (Distinction) - Dalhousie University OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS Memberships/Credentials 2011 - present International Group for the Study of Lithium treated patients - Member 2009 - present Nova Scotia College of Physicians & Surgeons - Member 2009 - present Royal College Physicians & Surgeons of Canada Certificant and Fellow 2005 - present Canadian Psychiatric Association - Member 1995 - present Canadian Medical Association Member 1995 present Canadian College of Family Practice - Member 1994 - present Licentiate, MCCQE Part 1 - Medical Council of Canada 1999-2006 American Board of Family Practice - Certificant 2
Research Support 2012-2015 The risk and burden of insulin resistance in bipolar disorder. Brain and Behavior Research Foundation (formerly NARSAD), principal investigator, $59,032 2010-2012 Sub-phenotyping bipolar disorder as a function of diabetes co-morbidity. Capital Health Research Fund, principal investigator, $14,949 International Collaboration Activities 2013 - Metabolic dysfunction in depression- biochemical and anthropometric markers and their relationship with cognitive functioning International collaboration with Dr Dorota Łojko, PI- Researcher-Poland 2011 - present International Group for the Study of Lithium treated patients (IGSLi) - IGSLi Member & researcher - Germany 2010 - present Pharmacogenomics of mood stabilizer response in bipolar disorder international study with Dr. John Kelsoe, PI - Researcher - California Mentoring Activities 2012 - present As assistant professor (Dalhousie University) - 6 mentorees 2010-2012 As Lecturer (Dalhousie University) - 11 mentorees Publications (Peer reviewed only) Cynthia V. Calkin, Martina Ruzickova, Rudolf Uher, Tomas Hajek, Claire M. Slaney, Julie S. Garnham, M. Claire O Donovan, Martin Alda: Insulin resistance and outcome in bipolar disorder. British Journal of Psychiatry, May 2014, In Press Tomas Hajek, Cynthia Calkin, Ryan Blagdon, Claire Slaney, Rudolf Uher, Martin Alda: Insulin resistance, diabetes mellitus and brain structure in bipolar disorders? Neuropsychopharmacology, May 2014, In Press. Tomas Hajek, Cynthia Calkin, Ryan Blagdon, Martin Alda: Type 2 diabetes mellitus - a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders. Biological Psychiatry. Nov 2013 Epub ahead of print. 3
Mirko Manchia, Martin Alda, Cynthia V. Calkin: Repeated erythromycin/codeine-induced psychotic mania. Clin Neuropharmacol. 2013. 36 (5): 177-178. Mirko Manchia Cynthia V. Calkin Martin Alda: Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: a Consortium on Lithium Genetics (ConLiGen) Report. PLoS ONE. 2013. 19;8(6):e65636. Cynthia V. Calkin, David Gardner, Thomas Ransom, Martin Alda: The relationship between bipolar disorder and type 2 diabetes: more than just comorbid disorders. Annals of Med 2013. 45: 171 181. Cynthia V. Calkin, Martin Alda: Beyond bipolar guidelines: Practical issues in long term treatment with lithium. Can J Psych. 2012. 57 (7): 437-45. Cynthia Calkin, Caroline van de Velde, Martina Ruzickova, Claire Slaney, Julie Garnham, Tomas Hajek, Claire O Donovan, Martin Alda: Can body mass index help predict outcome in patients with bipolar disorder? Bipolar Disorders 2009. 11 (6): 650-656. Martin Alda, Tomas Hajek, Cynthia Calkin, Claire O Donovan: Treatment of bipolar disorder: New perspectives. Ann Med 2008. 41 (3): 186-196. Cynthia V. Calkin, Carlo G. Carandang: Certain eating disorders may be a neuropsychiatric manifestation of PANDAS: Case report. J Can Acad Child Adolesc Psychiatry 2007 16 (3): 132-135. Abstracts C. Calkin, M. Ruzickova, C. Slaney, J. Garnham, R. Uher, C. O Donovan, M. Alda. Insulin resistance: An occult, modifiable risk factor for refractory bipolar disorder. International Journal of Neuropsychopharmacology Supplement. C. Calkin, M. Ruzickova, C. Slaney, J. Garnham, C. O Donovan, T. Ransom, M. Alda. Are comorbid insulin resistance and type II diabetes risk factors for refractory bipolar illness? European Neuropsychopharmacology supplement (ENP). C. Calkin, C. Slaney, M. Ruzickova, J. Garnham, C. O Donovan, T. Ransom, M. Alda. The risk of insulin resistance and type 2 diabetes mellitus in bipolar disorder. International College of Neuropsychopharmacology supplement (CINP). Presentations C. Calkin, M. Ruzickova, C. Slaney, J. Garnham, R. Uher, C. O Donovan, M. Alda. Insulin resistance: An occult, modifiable risk factor for refractory bipolar disorder. International Journal of Neuropsychopharmacology Supplement. Presented CINP Vancouver, 23 June 2014 4
C. Calkin, M. Ruzickova, C. Slaney, J. Garnham, R. Uher, C. T. Hajek, C. O Donovan, M. Alda. Co-morbid insulin resistance and type II diabetes predict chronic course of bipolar illness and poor response to lithium. Presented American Psychiatric Association (APA) Annual Meeting, New York City, 4 May 2014. C. Calkin, M. Ruzickova, C. Slaney, J. Garnham, C. O Donovan, T. Ransom, M. Alda. Are comorbid insulin resistance and type II diabetes risk factors for refractory bipolar illness? European Neuropsychopharmacology supplement (ENP), presented ECNP Barcelona, Spain, 6 Oct 2013. C. Calkin. Comorbid insulin resistance and type II diabetes may predict poor response to lithium. 2013 International Group for the Study of lithium treated patients (IGSLi) annual meeting. Dresden, Germany, 6 September 2013 C. Calkin. The role of early life adversity in bipolar disorder and diabetes. Presented as invited guest. Women in Psychiatry meeting, Halifax, NS. 20 Nov 2012 C. Calkin. Metabolic abnormalities in bipolar disorder. Presented as invited guest. 2012 New Brunswick Psychiatric Association Annual Meeting, Moncton, NB. 2 November 2012 C. Calkin, C. Slaney, J. Garnham, M. Ruzickova C. O Donovan, T. Ransom, M. Alda The risk and burden of insulin resistance and type 2 diabetes in bipolar disorder. 2012 International College of Neuro-Psychopharmacology (CINP) World Congress in Stockholm, Sweden 3-7 June 2012. C. Calkin. Bipolar Disorder and Metabolic Factors: Type 2 Diabetes, insulin resistance and metabolic syndrome. The Nova Scotia Bipolar Peer Support Alliance - Halifax Chapter presentation: 23 April 2012. C. Calkin. Medical Co-morbidity in bipolar disorder and the role of early life adversity. Clinical Academic Rounds Dalhousie University, Halifax, NS. 4 April 2012. C. Calkin, C. Van de Velde, M. Ruzickova, C. Slaney, J. Garnham, T. Hajek, C. O Donovan, M. Alda. Can body mass index help predict prognosis and outcome in bipolar disorder? 2011 WFSBP Annual Meeting. Prague, Czech Republic. 29 May- June 2, 2011. C. Calkin. Diabetes and metabolic factors in bipolar disorder. Presented as invited guest, 2010 International Group for the Study of lithium treated patients (IGSLi) annual meeting. Sardegna, Italy 1 October 2010 C. Calkin. Sub-phenotyping Bipolar Disorder as a Function of Diabetes Co-morbidity. Canadian Institute of Health Research: New Principal Investigators Meeting, Jackson Point, Canada, 19-21 November 2010 5
C. Calkin, C. Van de Velde, M. Ruzickova, C. Slaney, J. Garnham, T. Hajek, C. O Donovan, M. Alda. Body mass index correlates of bipolar disorder: Can BMI help predict prognosis and outcome? 2009 WFSBP Annual Meeting. Paris, France. 28 June - 2 July 2009. C. Calkin, C. van de Velde, M. Ruzickova, C. Slaney, J. Garnham, T. Hajek, C. O Donovan, M. Alda. Body mass index correlates of bipolar disorder: Can BMI help predict prognosis and outcome? Presented 2009 Society of Biological Psychiatry (SOBP) Annual Meeting Vancouver, Canada. 13-16 May 2009. C. Calkin, C. Van de Velde, C. Slaney, J. Garnham, M. Růžičková,T. Hájek, C. O Donovan, M. Alda. Body mass index correlates of bipolar disorder: Can BMI help predict prognosis and outcome? 2008 APA Annual Meeting in Washington, DC, USA. 3-8 May 2008. 6