Pharmaceutical Fine Chemicals. April 2015



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Pharmaceutical Fine Chemicals April 2015

Slide 2 of 19 Flarer S.A. is a Swiss Pharmaceutical Company, born in 1991, regularly inspected by the Swiss Authorities (Swissmedic). It is located in the Italian speaking part of Switzerland, on the lake of Lugano.

Slide 3 of 19 FLARER MAIN BUSINESS Active Pharmaceutical Ingredients (API) Cosmetic raw materials; Nutraceutical raw materials; Finished products; Packaging material; Patent holder: 3TabGum (3 layers medicated chewing gums through a direct compression production process).

Alberto Salini (President) alberto.salini@flarer.ch THE STRUCTURE OF FLARER Stefano Salini (Managing Director) stefano.salini@flarer.ch Renato Ferrari (Commercial Manager) Alex Bolognini (Marketing & Sales) Luigi Basaglia (Quality Assurance) renato.ferrari@flarer.ch alex.bolognini@flarer.ch info@flarer.ch Jolanda Bernasconi (Technical & Commercial Assistant) Simona Vanin (Commercial Assistant) Laura Ossola (Regulatory Affairs & Commercial Assistant) Cinzia Ossola (Book-Keeping) jolanda.bernasconi@flarer.ch simona.vanin@flarer.ch laura.ossola@flarer.ch cinzia.ossola@flarer.ch Slide 4 of 19

MANUFACTURERS REPRESENTED BY FLARER CANTABRA BCN IBERICA (HQ) CATALANA COPRIMA

Slide 6 of 19 MOEHS PRODUCT LIST Acebutolol HCl Choline Fenofibrate Irbesartan Metoprolol Tartrate Quinupramine Amantadine HCl Dihydralazine Mesylate Lansoprazole N-Acetylcysteine Rabeprazole Sodium Amantadine Sulphate Droperidol Lidocaine Base Nifedipine Sertraline HCl Amlodipine Besilate Dronedarone Lidocaine HCl Nifuroxazide Sotalol HCl Articaine or Carticaine Duloxetine HCl Magnesium Lactate Dihydrate Ofloxacin Sumatriptan Base Benzbromarone Entacapone Mebeverine HCl Olanzapine Sumatriptan Succinate Bisoprolol Fumarate Eseridine Salicylate Mepivacaine HCl Pantoprazole Sodium Telmisartan Bupivacaine HCl Fenofibrate Metoprolol Succinate Prilocaine HCl Tetrachlormethiazide Carbocysteine Gentisate Sodium Pyrantel Embonate Triamterene Carvedilol Guanethidine Sulfate Quetiapine Fumarate Trimebutine Maleate Celiprolol HCl Venlafaxine HCl

FROM MOEHS RESEARCH Late Stage of Development: Early Stage of Development: Under Evaluation: Ezetimibe Olmesartan Pregabalin Rivaroxaban Sitagliptin Vildagliptin Dexmedetomidine Levobupivacaine HCl Prasugrel Alogliptin Benzoate Canaglifozin Dapaglifozin Empaglifozin Enzelutamide Indacaterol Maleate * Products will not be offered or supplied tocountries where valid patents are in force Slide 7 of 19

Slide 8 of 19 PROTEOS PRODUCT LIST Skin Care Cellulite Treatment Eye Care Nail Care Keratoclean Hydra PB Renovenzyme PB Hyalucorrect PB Kernail-soft PB Keratoclean Sensitive PB Lipocel-erase Hydra PB Keratopeel PB Lipocel-erase Hydra Blue- Pink PB Lipocleansing Hydra PB Hyaldrain PB Lipocleansing Hydra Blue- Pink PB Lipocleansing Sensitive PB Lipocleansing Peel PB

Slide 9 of 19 Antacid Compounds BK GIULINI-ICL PRODUCT LIST Antiperspirants Rheological Additives Aluminium Hydroxide powders Aluminium Hydroxide Wet Gels Magnesium Hydroxide Powders Dihydroxy Aluminium Sodium Carbonate (Carbaldrate) Aluminium Phosphate Magnesium Aluminium Silicate Hydrate (Almasilate Types) ALOXICOLL - Aluminium Chlorhydrate ZIRKONAL Aluminium Zirconium GILUGEL Aluminium/Magnesium Hydroxyde Stearate Magnesium Hydroxide Suspensions Sucralfate Powder Aluminium Hydroxide Co-Dried / Co-Blended Gels Sucralfate milled Powder Magaldrate Sucralfate Powder for direct compression Hydrotalcite Sucralfate Suspension Almagate

Slide 10 of 19 Paracetamol Powder Grades: Paracetamol DC Grades: ATABAY PRODUCT LIST Fine Powder APC 150 Extra Fine Powder APC 152 Micronized Powder APC 154 83 % DC APC 210 90 % DC APC 230 C 90 % DC/C APC 230 CP 96 % DC APC 242 C 96 % DC + 4 % Maize Starch APC 242 C/MS 96 % DC + 4 % PVP APC 242 FP Crystals-Capsule Grade APC 162 90 % DC APC 230 C/MS 96 % DC + 4 % PVP APC 242 P SP Powder APC 194 Super Fine Powder APC 196 Powder APC 198 90 % DC APC 230 C/MS-1 90 % DC + 10 % Pregelled Maize Starch APC 230 F/MS 97 % DC APC 244 97 % DC + 3 % PVP APC 244 P

SYNBIAS PRODUCT LIST Product List: At late stage of development: At early stage of development: Doxorubicin Bendamustine HCl Epirubicin Everolimus Idarubicin Rapamycin Vinorelbine * Products will not be offered or supplied to countries where valid patents are in force Cabazitaxel Cladribine Clofarabine Decitabine Fludabarine Irinotecan Lenalidomide Mitoxantrone Nelarabine Topotecan Valrubicin Slide 11 of 19

Slide 12 of 19 BIOEQUAL PRODUCT LIST Nails Skin Joints Phyto Nail Pen Anti Wart Pen Anti-Aging Cream L-Proline Tablets Nail Strengthener Pen Cellulite Cream Anti Wrinkle Cream L-Proline Sachets Spider Vein Cream Skin Care Cream L-Proline Topical Gel Couperose Cream Wound Cream

ZELLAEROSOL PRODUCT LIST Slide 13 of 19 Fill-in Aerosols (sprays and foams) Pump sprays Two-chamber packages of different systems Liquids Roll-ons Containers made of aluminium, tinplate, glass and plastics. Injection-moulded articles Protective caps for aerosols Adapters Plastic spouts Others Screen printing Fuel for lighters Gas for refillable lighters Non-resinating light lubricating oil Haircare Hairsprays Volume mousse Hair laquer Grossing spray Powder spray Bodycare Body wash / cleaning foam Sun lotions / Sun foams Hand lotion Body lotion / Body foam After bite lotions Gel sprays Deodorants Deosprays Deosprays for footcare Miscellaneous Mouthspray Repellents Refreshing sprays Impregnation spray Room freshner Carpet sprays Marking spray for different purposes

Slide 14 of 19 FLARER ALSO HAS PARTNERSHIPS WITH COMPANIES DEVELOPING: Active Pharmaceuticals Ingredients Plant extracs Medicated Chewing Gums Packaging solutions

Slide 15 of 19 ACTIVE PHARMACEUTICAL INGREDIENTS 3,4-Difluoro Nitrobenzene Buspiron HCL Dinoprost Fosphenytoin Milrinone Acetylcholine Chloride Captopril Dolasetron Gemcitabine Moexipril Alprostadil (Prostaglandin E1) Chitosan Doxazosin Mesylate Gentamycin Sulphate Palonosetron Apomorfina Chlorphenesin Enalapril Maleate Glyloid TT-100 Pangamate Sodium Atovaquone Chondroitine Sulfate Enalaprilat Ketotifen Pemetrexed Disodium Atracurium Besylate Cis-Atracurium Eparin Lisinopril Perindopril Erbumine Benazepril Daptomycin Esculin Loperamide Pilocarpine Nitrate Benzalkonium Chloride Deanol-p-Acetamodobenzoate Finasteride Loratadine Pirenoxine Benzocaine Diclofenac Sodium Fluorescein Sodium Metformin HCl Potassium Sulfoguayacolate Beraprost Sodium Diclofenamide Flupirtine Maleate Metronidazole Prednisolon * Products will not be offered or supplied to countries where valid patents are in force

Slide 16 of 20 Under development Procaine Tamoxifen Citrate Atropine Base Fosaprepitant Quinapril Timolol Atropine Sulphate Gefitinib Ramipril Tobramycin Abiraterone Acetate Lurasidone Resorcinol Trandolapril Bortezomib Ractopamine HCl Rocuronium Bromide Tropicamide Darifenacin Silodosin Sodium Cromoglycate TSP (Tamarind Seed Polysaccharide) Everolimus Sitagliptin Sodium Ialuronate Tyloxapol Fexofenadine HCl Tetrabenazine Solifenacin Succinate Vancomycin * Products will not be offered or supplied to countries where valid patents are in force

Slide 17 of 20 PLANT INGREDIENTS BY CO2 EXTRACTION African Copal Bark Caraway Evening Primrose Seed Juniper Berries Oregano leaf Sawpalmetto barries Ajowain Fruits Cardamom Fennel Kava-kava root Orris root Schisandra fruit Allspice Barries Carrot Fenugreek seed Lavender flower Paprika Seabuckthorn berries Amaranth Seed Celery Seed Feverfew Lemon myrtle Parsley seed Seabuckthorn pulp Angelica Root Chia Seed Flavoxan Licorice root Peanut seed Soy germ Antimicrobial Blend Chili Frankincense Lovage root Peppermint leaf St. John s wort Arnica Flower Cinnamon Bark Galangal Root Mace Pomegranate seed Star anise Balm Leaf Clove Bud Galbanum Mango ginger Raspberry seed Tagetes flower Basil Leaf Coconut Garlic Marigold flower Rhatany root Thyme Black Cumin Coffee Ginger Marjoram leaf Rosehip (+seed) Usnea lichen Borage Seed Coriander GlucodOX Massoia bark Rosemary (+Antioxidant) Vanilla Planifolia Butter Cumin Seed Gromwell Root Millet seed Sage antioxidant (officinalis) Vanilla Tahitensis Calamus Curcuma Hazelnut Musk seed Sage Triloba Wheat bran Camomille Flower Dill Seed Hop Myrrh

Slide 18 of 20 Multilayer Chewing Gums MEDICATED CHEWING GUMS - FINISHED PRODUCTS - VisionGum LactiGum SensitiveGum ImmuneGum Q10Gum CavityGum DietGum MultivitGum WhiteGum EnergyGum

PACKAGING SOLUTIONS Ampoules Vials Chromatography GLASS (pharmaceuticals) GLASS (cosmetic) Bottles Vials Jars Closures Slide 19 of 20 Tubes PLASTIC (cosmetic) ALUMINIUM (cosmetic) CLOSURES

Slide 20 of 20 Alberto Salini Stefano Salini Renato Ferrari Alex Bolognini President alberto.salini@flarer.ch Managing Director stefano.salini@flarer.ch Commercial Manager renato.ferrari@flarer.ch Marketing & Sales alex.bolognini@flarer.ch CONTACT US Flarer S.A. Via Pian Scairolo 11 6915 Lugano-Noranco Switzerland Tel. +41 91 / 912 31 81 Fax. +41 91 / 912 31 88 e-mail: info@flarer.ch www.flarer.ch