Dimethyl 2-methylglutarate

GPS Safety Summary Chemical Identity Dimethyl 2-methylglutarate Brand names Rhodiasolv IRIS CAS number 14035-94-0 Chemical name (IUPAC) 2-methylpentanedioic acid, dimethyl ester Molecular formula C 8H 14O 4 Synonyms Pentanedioic acid, 2-methyl-, 1,5-dimethyl ester Molecular weight 174.19 g/mol Applications Dimethyl 2-methylglutarate is used as solvent for various applications such as industrial cleaning, resin clean-up, foundry resins, paint stripping, paints and coatings formulations. It is also used as solvent in consumer products, such as household cleaners and personal care products. Safety Assessment, Exposure and Risk Management Recommendations Physical and chemical properties Property Physical state Liquid at room temperature Colour Colourless Odour Characteristic Boiling point 215.6 C Relative density 1.05 Flash point 98 C (closed cup) Vapour pressure 0.063 hpa at 20 C Water solubility 25 g/l at 20 C Octanol water partition Low potential for bioaccumulation Health effects Dimethyl 2-methylglutarate is not classified as dangerous for human health. Safety measures must be observed for industrial and professional uses. For details, please refer to the Safety Data Sheet. Environmental effects Dimethyl 2-methylglutarate is harmful to aquatic organisms. However, as it is readily biodegradable and not potentially bioaccumulative, it is not classified as dangerous for the environment. Emissions to the air are not expected. Disposal, treatment and recycling must comply with applicable regulations to preserve environment. Regulatory information and certifications Classification and labelling EU regulation (EC) 1272/2008 (CLP) Classification Dimethyl 2-methylglutarate is not classified regarding physical and chemical hazards nor is it classified for human health or for the environment, according to the regulation criteria. Registration and certification EU regulation on chemicals (EC) 1907/2006 (REACH) ISO 9001: 2008 certified Labelling No pictogram, no signal word, no Hazard or Precautionary statement. Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 I/I

GPS Safety Summary This Product Safety Summary is intended to provide a general overview of the chemical substance in the context of ICCA Global Product Strategy. The information on the Summary is basic information and is not intended to provide emergency response information, medical information or treatment information. The summary should not be used to provide in-depth safety and health information. In-depth safety and health information can be found on the (extended) Safety Data Sheet (e)sds for the chemical substance. General Statement Dimethyl 2-methylglutarate Dimethyl 2-methylglutarate is a colourless liquid organic compound with a mild characteristic odour. It has a very low vapour pressure and is miscible with most common organic solvents. It is not classified as dangerous for human health and for environment, based on available data. Dimethyl 2-methylglutarate is used as solvent in a wide range of applications, such as industrial cleaning, paint stripping, paint and coating formulations, and foundry resins. Biodegradable, non-flammable and non-voc (Volatile Organic Compound) according to EU legislation, it is used as an eco-friendly alternative to many traditional chlorinated or high VOC solvents. Dimethyl 2-methylglutarate use in consumer products is minor, it may be found in coating formulations, cleaning agents or personal care products where it is formulated in suitable concentrations for consumer applications, according to appropriate regulations, to ensure safe use of the final product, in the conditions of use written on the product packaging. Chemical Identity Name: Dimethyl 2-methylglutarate Brand names: Rhodiasolv IRIS Chemical name (IUPAC): 2-methylpentanedioic acid, dimethyl ester dimethyl 2-methylpentanedioate Synonyms: Pentanedioic acid, 2-methyl-, 1,5-dimethyl ester CAS number(s): 14035-94-0 EC number: 604-181-2 Molecular formula: C8H14O4 Structure: Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 1/6

Uses and applications Dimethyl 2-methylglutarate is a dibasic ester-based solvent. It is used as an alternative to traditional solvents in a large range of industrial and professional applications, such as resins manufacture clean-up, foundry resins, industrial coil and can coatings, paint strippers. It can be used for general purpose industrial cleaning for heavily soiled substrates or as plastic manufacture and processing solvent. Dimethyl 2-methylglutarate is also used as solvent in consumer products, such as household cleaners or cosmetics and personal care products. Physical/Chemical Properties Phys/Chem Safety Assessment Property Value Physical state Liquid at 20 C and atmospheric pressure Colour Colourless Odour Characteristic Molecular weight 174.19 g/mol Relative density 1.05 Freezing point < - 75 C Boiling point 215.6 C Flash point 98 C (closed cup) Explosive properties Non explosive Self-ignition temperature 430 C Vapour pressure 0.063 hpa at 20 C Water solubility 25 g/l at 20 C Octanol Water partition coefficient (log Kow) 0.89 at 25 C Based on available data, dimethyl 2-methylglutarate is not classified regarding physical and chemical hazards, according to EU regulation (EC) 1272/2008. Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 2/6

Health Effects Human Health Safety Assessment Effect Assessment Acute Toxicity Oral/inhalation/dermal Irritation / corrosion Skin/eye/respiratory tract Sensitisation Toxicity after repeated exposure Oral/inhalation/dermal Genotoxicity / Mutagenicity Carcinogenicity Toxicity for reproduction Not classified for acute toxicity for all three routes of exposure. Not irritating to skin and eyes. Not classified as sensitising to the skin, based on animal data. Low toxicity after repeated exposure by inhalation and oral route, not resulting in classification. At high concentrations, possible effects on the olfactory epithelium. No data on dermal repeated toxicity, but expected to be low owing to negligible skin absorption potential. Not classified either for mutagenicity or genotoxicity. No data available. No adverse effect on fertility and on development based on in vivo experimental study results. All these results are based on available data. Regarding toxicological hazard, dimethyl 2-methylglutarate is not classified according to EC 1272/2008 regulation criteria. Environmental Effects Environment Safety Assessment Effect Assessment Aquatic Toxicity Fate and behaviour Biodegradation Bioaccumulation potential PBT / vpvb conclusion Harmful to fish and algae. Not harmful to invertebrates. Readily biodegradable. Not potentially bioaccumulative. The substance is considered to be neither persistent and bioaccumulative and toxic (PBT) nor very persistent and very bioaccumulative (vpvb). Based on available data, dimethyl 2-methylglutarate is considered as harmful to aquatic life, but since it is readily biodegradable and not potentially bioaccumulative, it is not classified as dangerous for the environment, according to EU regulation (EC) 1272/2008. Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 3/6

Exposure Human health Dimethyl 2-methylglutarate is manufactured in industry in closed processes which ensure that the risk is controlled. Where there is a risk of exposure to the substance, during (un)loading, sampling, analysis or maintenance operations and particularly in case of batch processes and spray applications, the exposure should be kept as minimum as possible by the use of appropriate risk management measures as suitable collective and personal protective equipment, good industrial hygiene practices and risk communication through appropriate training of workers. In end-use products like houshold cleaners or personal care products, dimethyl 2-methylglutarate is formulated to comply with requirements of the most stringent regulations for all applicable consumer uses to ensure that final products are used safely in the conditions of use written on the packaging. Environment Based on its physico-chemical properties, dimethyl 2-methylglutarate has a low potential for bioaccumulation and is readily biodegradable. It would be expected to partition predominantly into the aquatic compartment and not to adsorb on soil. Emissions in the air are not expected as the substance has a low potential for volatility. On industrial manufacturing and professional sites, effluents that may contain the substance must be directed to a waste water treatment plant. Due to its ecological properties, an indirect exposure of humans to dimethyl 2-methylglutarate via the environment is not expected. Risk Management Recommendations Human health For industrial and professional uses of dimethyl 2-methylglutarate and as recommended for the use of any chemical product, workers must be well informed and trained and must refer to the Safety Data Sheet (SDS). Where there is a risk of exposure to dimethyl 2-methylglutarate (during (un)loading, mixing, sampling, analysis or maintenance operations and particularly in case of batch processes and spray applications), it must be controlled by handling the substance under an adequate and efficient ventilation. Appropriate Personal Protective Equipment (PPE) must be worn (safety goggles, gloves, protective suit) as recommended in the SDS. In case of exposure to vapours or aerosol, a respirator with approved filter should be used. General industrial hygiene measures are required to ensure safe handling of the substance: Emergency equipment immediately accessible; use well-maintained PPE; wash hands and skin following contact; do not eat, drink or smoke at the workplace. For consumer uses, dimethyl 2-methylglutarate is formulated in suitable concentrations according to appropriate regulations, to ensure safe-use of the final products, in the conditions of use written on the product packaging. Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 4/6

Environment All industrial aqueous releases that may contain the substance must be directed to a waste water treatment plant or incinerated in compliance with local regulation. Disposal, treatment or recycling of industrial waste must comply with applicable regulations to preserve environment. State Agency Review This substance has been registered under the EU Regulation (EC) 1907/2006 (REACH). Regulatory Information / Classification and Labelling Substance classification and labelling according to EU regulation (EC) 1272/2008 (CLP): Classification Dimethyl 2-methylglutarate is not classified regarding physical and chemical hazards and is not classified either for human health or for the environment. Labelling No pictogram, no signal word, no Hazard or Precautionary statement. Contact Information within Company GPS Contact: GlobalProductStrategy@solvay.com Solvay GPS Safety Summaries: http://www.solvay.com/en/sustainability/product-responsibility/product-safety-summaries/index.html Additional Information ICCA Global Product Strategy: http://www.icca-chem.org/en/home/icca-initiatives/global-product-strategy/ Glossary of technical terms: http://www.solvay.com/en/sustainability/product-responsibility/product-safety-summaries/glossary.html Solvay website: http://www.solvay.com Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 5/6

Date of issue: October 2013 Revision: 0 Disclaimer The information provided in the present Safety Summary is based on European data available in REACH regulatory dossier (EC N 1907/2006) and is correct to the best of our knowledge, information and belief at the date of its publication. Such information is only intended to provide a general overview of the chemical substance in the context of ICCA Global Product Strategy and is not to be considered as a warranty or quality specification. It does not replace the safety data sheet and technical sheets. Thus, the information provided in this Safety Summary only relates to the designated specific product and may not be applicable if such product is used in combination with other materials or in another manufacturing process, unless otherwise specifically indicated. It does not release the user from ensuring he is in conformity with all regulations linked to its activity. Dimethyl 2-methylglutarate GPS Safety Summary Rev 0 October 2013 6/6