ANNUAL REPORT 2009 / 2010

MHeNS School for Mental Health and Neuroscience ANNUAL REPORT 2009 / 2010 School for Mental Health and Neuroscience Faculty of Health Medicine and Life Sciences

Content Preface Professor Dr. Harry Steinbusch 5 1. Future directions of MHeNS and EURON 7 2. Organisation structure 13 3. Divisions 17 3.1. Division I 19 3.1.1 Research lines 20 3.2. Division II 23 3.2.1. Expert groups 24 3.3. Division III 29 3.3.1. Research lines 30 2 4. Facts and Figures 37 3 4.1. Earning Power 39 4.2. Research Staff 45 5. Output results 47 5.1 Output results of the School Output 2009-2010 49 5.2 Best publications 2009-2010 49 5.3 PhD theses Div I 2009-2010 53 PhD theses Div II 2009-2010 54 PhD theses Div III 2009-2010 55 6. Master and PhD Educational Activities 57 6.1. Master Programme 59 6.2. PhD Programme 60 Annexes: 1. Overview Education PhD Programme 64 2. Current PhD theses 70 3. Publications 2009 2010

Preface 4 harry steinbusch scientific director I am pleased to provide our Annual Report 2009-2010. It presents an overview of the work and full information concerning the School for Mental Health and Neuroscience in the fields of research output, earning power, staff members and postdoctoral teaching activities in 2009-2010. The School has grown further not only regarding the number of publications as requested by the Faculty of Health, Medicine and Life Sciences but also in the quality of the papers as indicated by an increase in the average impact factors. The increase in non-tenured staff members has resulted in a steady increase in the number of PhD theses from 22 in 2009 to 30 in 2010. Our School now hosts about 170 PhD students. The guidance of these students is a significant challenge that requires an enormous and coordinated effort of staff members. In accordance with the performance contract with the Faculty of Health, Medicine and Life Sciences we have focused on establishing more funding from NWO (Dutch Medical Research Council) and FP7- EU grants, which has resulted in depending less on grants obtained from other peer-reviewed agencies. Grants obtained from industrial contract research now represent a more limited component of our funding. We are pleased to note that in this period several young investigators were successful in obtaining Mosaic, VENI or VIDI grants, such as those awarded to Drs. Temel, Rutten, Janssen and Germeys. Consequently, we can state that during this period we fully achieved all the goals of our performance contract. Another important event during this period was the application for re-accreditation of EURON and, thereby, implicated that of the School of Mental Health and Neuroscience. An evaluation of the External Research Committees (ERC) was carried in September 2009 when the committee visited the campus. In addition to the Research Director and the Division Leaders evaluated previously by the ERC, some Project Leaders, supported by competitive peer-reviewed financing, postdocs, Ph.D. students and the educational platform, were evaluated. All research groups were assessed as deserving continuous support. During this evaluation process, we received very valuable feedback regarding our strengths and weaknesses. These comments were used for our return visit at the ECOS (Evaluation Commission Research Schools) commission February 2010 at the Royal Dutch Academy of Arts and Sciences in Amsterdam. We were pleased that after the external research committee forwarded their positive comments to the ECOS commission, the KNAW decided by July 15th, 2010 to award us the official re-accreditation for another 6 years, 2010-2016. In 2009, a discussion was started concerning the appropriate size for an Institute. In accord with its merits, MHeNS has been regarded as sufficiently large to act as an independent School within the university. Nonetheless, we would like to note that although we are one of the smaller Schools within the Faculty of Health, Medicine and Life Sciences, we still produce the largest number of high impact papers, Ph.D-students and a well-organized Master program. However, it is worth noting that neuroscience research is still quite fragmented in the capital area. This speaks to the need for closer cooperation among the different units. To this end, we have reorganized our clinical groups and divisions, although we will still have three divisions. Thus, one division will be clearly focused on Cognitive Neuropsychiatry and Clinical Neuroscience, one division will be on Environmental Psychiatry and the third one will focus on Fundamental and Systems Neuroscience. In with this, educational activities of the Master s programs corresponds to these subdivisions. The strength of MHeNS is in its translational approach. For example, division 1 concerns neuroepidemiology and brain imaging, division 2 focuses on gene-environmental changes/interactions related to psychiatric disturbances such as psychoses, and division 3 5

6 uses animal and cellular models related to systems-level research. These lines of research at MHeNS will continue to find much synergy within collaborative projects and research networks. The proportion of foreigners on staff has been steadily increasing from the inception of MHeNS in 2002, attaining approximately 26% for researchers in 2010. The Research Master Degree Program in Neuroscience EMN (The European Master in Neuroscience) was initiated (in early 2009) by EURON in cooperation with our partners. The first round of the teaching program will be implemented in September 2013 and the first student should graduate from the program in the middle of 2015. All research groups of our EURON partners will participate in teaching in EMN so that all major research areas of the Fundamental and Systems Neuroscience program will be covered. In this master we will bring together the best expertise available from all participating eleven universities, so that an excellent and stimulating program can be offered to the new students. In conclusion, I would like to thank all members of MHeNS for contributing their knowledge and expertise to the School and students in the past years. Importantly, these changes and improvements that have been made will create new opportunities for the upcoming years. I look forward to new directions and challenges in the restructured academic environment in the coming years. Prof. Harry W.M. Steinbusch Scientific Director School for Mental Health and Neuroscience chapter 1 Future directions of MHeNS and EURON

Future directions of MHeNS and EURON This mission can be made possible by building on multidisciplinary approaches. Therefore, as a foundation we will continue to educate and train Master and PhD students to become independent researchers who are able to plan and execute cutting edge science and to function well in multidisciplinary research programs in academia and/or industry. This will be achieved by sharing expertise and knowledge among all EURON partners and by stimulating mobility of Master and PhD students. In addition, we will strive for uniformity or comparability of standards for PhD degrees among the three participating countries, i.e., the Netherlands, Belgium and Germany. Indisputably, the training of young competent PhD s in the Neurosciences is crucial to maintaining the competitiveness of the European community in Neuroscience-based research. The new generation of our neuroscientists should be capable of integrating information across different levels of research. Similarly, they should be competent to participate in integrative projects as a next step in elucidating the complex interplay between multiple genetic and environmental factors in order to reveal how this interplay translates into normal brain function and/or disease. The mission of the School for Mental Health and Neuroscience European Graduate School of Neuroscience (EURON) at Maastricht University and the European Graduate As mentioned above EURON has been re-accredited by the School for Neuroscience, EURON, at the Euregional level is Royal Dutch Academy of Arts and Sciences (KNAW) from threefold: 2010 to 2016. The external review committee (ERC) has 1. focusing on a basic understanding of brain function made some clear observations concerning MHeNS in relation and disease mechanisms, to EURON. The report of the ERC identifies MHeNS as 2. understanding the function of genes and proteins, cellular the prime coordinator of EURON and states that MHeNS is processes and neuronal networks in relation to in a favourable position to continue to develop as a centre human health, of excellence in Europe. The shared expertise, knowledge 3. establishing reciprocal translational links between lab and infrastructure of EURON will facilitate this goal. The and clinic. ERC emphasizes that current leadership of MHeNS has 8 developed an excellent research training program, mak- 9 ing optimal use of the geographical Euregional location and opportunities for EU funded programs. The committee stated that the PhD program and the supervision is very good and of importance for PhD students on many levels, e.g., sharing expertise, knowledge transfer, mobility opportunities and opportunities for learning new techniques. In addition, EURON aims to produce uniform PhD degrees of the highest quality and to execute the Bologna process. The translational research focus of MHeNS to perform high impact translational neuroscience research fits very well with the mission of EURON to address research topics in a multidisciplinary approach. Strategic Goals for the School for Mental Health and Neuroscience at Maastricht University 2011 2015 The School will be facing in the immediate forthcoming period some important changes. However, we believe change will also create opportunities. The first opportunity is related to the establishment of the Maastricht University Medical Center (MUMC) and the fact that the MUMC has decided to stimulate and invest an amount of H 2 million for the expansion of the research capacity of MHeNS. The School

has added to this from their own resources an additional H 0.5 million, which brings the total investment to H 2.5 million. The additional funding provided by MUMC will be deployed with a view to put in effect and consolidate strategic choices for expansion and strengthen the positions of postdocs and researchers at the assistant professorship level. At present, all these positions are, unfortunately, nontenured while what is really needed is tenure-track positions to support and recruit excellent career-oriented staff members from within or beyond. Recently, an analysis of the five Schools by the MUMC Governing Board was conducted. As a result, it was decided that the criteria for carrying the certificate of Centre of Excellence include that a School should have sufficient critical mass to guarantee sufficient PhD-output and demonstrate the ability of staff to obtain VENI, VIDI and VICI, comparison with the other UMCs in the Netherlands, and 2) the wish that patients in both the short and long term should benefit from research. MHeNS also recognizes the need for a translational approach. Theme 1: Gene-Environmental Changes in Psychiatric Diseases In this research line participating groups are identifying A specific point deserving of attention is our partnership interactions between genes and environment, neuroimaging with the Faculty of Psychology and Neuroscience (FPN). In (i.e., identifying cerebral phenotypes for the study of our School within Division 1, the Department of Psychopharmacology, ecogenetics) and experimental psychology and psychopready (FPN) headed by Prof. Dr. J. Ramaekers alharmacology (i.e., identifying experimental psychological Thus, to summarize, the focus of MHeNS will be on various participates. In addition, there is a strong link with and psychopharmacological phenotypes for the study of levels: educational activities at the level of the Research Master ecogenetics). This will facilitate the early recognition and 1. Research: three divisions work on, two translational research Program Cognitive and Clinical Neuroscience in which the treatment of psychiatric disorders, in particular psychosis themes, bridging the boundaries between the School is involved in 3 of the 4 tracks. It should be noted and depression, leading ultimately to mental health services three divisions, 10 awards as well as grants from major organizations such as that the FHML is the principal coordinator of two tracks of research. 2. Education: further expanding and strengthening Re- 11 the Netherlands Foundation for Scientific Research (NWO). An analysis by the Board has revealed that MHeNS meets all these criteria. Another consideration regarding Strategic Goals for the next 4 years is the implementation of a ZKO, a Care Clinical Research Unit, headed by Prof. Dr. J. van Os. The MUMC is a fusion of the FHML with the Academic Hospital Maastricht which took place in 2008. This new ZKO Mental Health and Neuroscience initiative that started in 2009 will deal with all aspects of mental health related issues related to research, patient care and education in the Academic Hospital Maastricht. The ZKO is not formally integrated into the School but the two entities partly overlap with each other. As mentioned before this relationship has resulted in direct opportunities for translational research from bed to bench and vice-versa. Finally, we would like to provide some additional thoughts with respect to EURON. We have mentioned before that MHeNS is a fully integrated partner in EURON. However, EURON comprises nine other universities in the Euregio as well. MHeNS has been taking the lead in all organizational aspects. Currently only divisions 2 and 3 of MHeNS are participating within EURON. It should be expanded to other research areas. Because it already provides an excellent opportunity for networking, further Euregional activities and introducing an international or European Master in Experimental and Clinical Neuroscience have great potential, which we will incorporate in the next period. the Research Master. We would like to build further and even strengthen our partnership with other groups in FPN, such as the Neuroimaging group of Prof. Dr. R. Goebels and the Neuroplasticity group of Prof. Dr. P. De Weerd. These partnerships are important for research and educational exchanges and could be a basis for a further growth towards a Neuroscience Campus Maastricht (NCM). The foundation of our future plans is that the research within MHeNS is divided into the three reorganized divisions. The choice for three divisions is based upon methods-related considerations: division 1 on patient care related cognitive neuropsychiatry and clinical neuroscience; division 2 on patient care-related gene environment investigations, and division 3 on animal models for neurodegenerative disorders. However, all these three divisions will have a major focuses towards two translational themes: 1: Gene-Environmental Changes in Psychiatric Diseases and 2: Neurodegeneration and Plasticity as outlined below. This way, critical mass will be created and the research will acquire additional prominence within the MUMC. The specific focus on translational themes is in line with 1) the wish of MUMC to have a specific translational research focus in Theme 2: Neurodegeneration and Plasticity In this research line there is a direct link between clinical applied human research towards mechanistic approaches using transgenic mouse and rat models for neurodegeneration. Thus, participating fields within this translational line include quantitative neuromorphology, molecular neurobiology, behavioural neuroscience, neuroimmunology, neuroimaging and psychopharmacology. These involve clinical services for adult neurodegenerative disorders and developmental cognitive disorders, both from the point of view of early detection and intervention and from the point of view of health services research. In addition a large number of molecular neurobiological questions can be addressed. To summarize, MHeNS clearly wants to move forward and establish further its Center of Excellence level. To achieve this status we first need a critical mass. To a certain extent this is beyond our control and, therefore, should be encouraged/facilitated by the MUMC in the form of concrete rewards (financial support) as successive, specified goals are achieved. We have already increased a variety of funding opportunities and we will continue to do so thereby increasing the number of Ph.D. students and postdocs. However, to increase critical mass at the tenure-track level we need full cooperation and support by the MUMC and UM. We intend to garner international recognition of each of the two research lines, showing this consistently on a translational level. In this way we clearly will distinguish ourselves within the national competition. We are now ready for the next step. It is our hope that all members of MHeNS can join together on this in the time to come. search Master, Ph.D. and postdoctoral activities, 3. Collaboration: further exploring the possibilities for a two faculty based Neuroscience Campus Maastricht.

12 chapter 2 Organisation structure

Organisation structure MHeNS is managed by the Board of MHeNS. The board is the body where strategis issues are discussed and effectuated. It consists of five members: the scientific director, the managing director and the three division leaders. Dean of the Faculty Health, Medicine and Life Sciences Prof. Dr. Martin Paul Managing Director Laurent Louwies Scientific Director Prof. Dr. Harry Steinbusch Cognitive Neuropsychiatry and Mental Health Neuroscience Clinical Neuroscience 14 15 Prof.Dr. Frans Verhey Deputies Dr. Martin van Boxtel Dr. Caroline van Heugten FHML Psychiatry & Neuropsychology (section Neuropsychology) Prof.Dr. Inez Myin-Germeys Deputy Dr. Koen Schruers Psychiatry & Neuropsychology (section Psychiatry) Prof.Dr. Marc de Baets Deputies Prof.Dr. Martin van Kleef Dr. Yasin Temel Core departments: Psychiatry & Neuropsychology (section Neuroscience) * Restructuring of the divisions in 2009-2010. Movement Sciences (2009)* General Practice Radiology Othorhinolaryngology (2010)* Neurology (2010)* FPN Neuropsychology & Psychopharmacology Clinical Neuropsychology (2010)* Neurosurgery Anesthesiology Urology Othorhinolaryngology (2009)* Ophthalmology Neurology (2009)* Non core departments: Clinical Neuropsychology (2009)* Pediatrics Internal medicine Figure 2.1 Organogram of MHeNS: the contribution of the different Departments of FHML to the current three Divisions of MHeNS.

Members of EURON MHeNS is the coordinator of the European Graduate School of Neuroscience [EURON]. EURON is a research and training network of 10 universities in the three countries Belgium, Germany and the Netherlands. 16 EURON MHeNS Belgium Université Libre de Bruxelles Universiteit Hasselt Katholieke Universiteit Leuven Université de Liège Université Catholique de Louvain Germany RWTH Aachen University University of Bonn University of Cologne The Netherlands Maastricht University (MHeNS) Radboud Universiteit Nijmegen (2009)* Figure 2.2 EURON in relation to MHeNS. * RU Nijmegen has withdrawn partnership in EURON since Dec. 2009. chapter 3 Divisions

Divisions Goals & Results 2009-2010 3.1 Division I: Cognitive Neuropsychiatry & Clinical Neuroscience Division Leader: Prof. Dr. Frans Verhey Deputies: Dr. Martin van Boxtel Dr. Carolien van Heugten Dr. Paulien Aalten Dr. Jos Adam Dr. Marjan van den Akker Prof. Dr. Bert Aldenkamp Dr. Lucien Anteunis Dr. Walter Backes Prof. Dr. Jan Willen Cohen Ter Vaart Dr. Jeanette Dijkstra Dr. Annelien Duits Dr. Carin Faber Dr. Ellen Gerrits Dr. Ed. Gronenschild Prof. Dr. Fred Hendrikse Dr. Paul Hofman Prof. Dr. Raymond Hupperts Dr. Vivian Kranen van Mastenbroek Prof. Dr. Herman Kingma Prof. Dr. Bernd Kremer Dr. Marc de Krom Dr. Abraham Kroon Dr. Albert Leentjens Prof. Dr. Peter de Leeuw Prof. Dr. Werner Mess Prof. Dr. Job Metsemakers Dr. Robert van Oostenbrugge Dr. Rudolf Ponds Dr. Sascha Rasquin Prof. Dr. Harry Uylings Dr. Wim van der Elst Dr. Pieter - Jelle Visser Prof. Dr. Hans Vles Dr. Marjolein de Vugt Dr. Wim E.J. Weber Prof. Dr. Joachim Wildberger 18 Dr. Claire Wolfs 19 Goals & Results CNP-&CNS performs fundamental and applied research on brain-cognition relationships. CNP-&CNS mission is to generate new insights into neurocognitive and neurobehavioural mechanisms in order to improve treatment and care for people with cognitive disorders, and other neurological disorders. Since 2009, clinical neuroscience researchers have been assigned to the Division 1 and the new name became Cognitive Neuropsychiatry & Clinical Neuroscience (CNP-&CNS), covering the translational nature of the Division 1 research program. With respect to the medical conditions, the focus is upon neurodegeneration in relation to neurodegenerative diseases of the central nervous system, such as Alzheimer s disease and its prodromal phases, Parkinson s disease, peripheral nervous system disease such as small fiber neuropathy, acquired brain damage such as stroke, traumatic brain injuries, and epilepsy. The general goal of the division is to develop new insights into the neurocognitive and neuro-behavioral mechanisms in order to improve treatment and care for people with such conditions. We investigate the contribution of biological, neuropsychological and psychosocial factors, single and in combination, and the effect of ageing on the development of normal neurocognition and mild to severe cognitive dysfunction. Research in Division 1 is conducted in a multi-disciplinary way, with contributions of researchers from neuropsychology, cognitive neuroscience, neuropsychiatry, clinical neurology, neuroradiology and neuro-epidemiology. In 2009-2010 we continued to investigate normal, successful and pathological ageing, but with a greater emphasis on the translational focus. Programs and projects in the domains of neuroimaging and biomarkers were expanded by further adoption of HTA (Health Technology Assessment) approaches. The allocation of the clinical neuroscience researchers and radiologists in the division has strengthened the neuro approach of the division, enabling a strong research program in which cognitive and clinical neurosciences are integrated.

3.1.1 Divisie I Research lines, staff Research-Line: P.I.: Neurodegenerative disorders: mechanisms, early diagnosis and biomarkers Prof. Dr. F. Verhey, Dr. P-J Visser, Dr. P. Aalten, Dr. R. van Oostenbrugge, Dr. A. Leentjens, Dr. M. van Boxtel, Research-Line: P.I.: Neuropsychological interventions and cognitive rehabilitation Dr. C. van Heugten, Dr. M. de Vugt, Dr. R. Ponds, Dr. M. van Boxtel, Prof. Dr. F. Verhey PhD students: Drs. A. Colon, Drs. F. van Dooren, Post doc/ Drs. K. Beerhorst, Drs. R. Besseling, Dr. A. Duits Drs. O. Schiepers, Drs. P. Spauwen, PhD students: Drs. I. Brands, Drs. M. van Eeden, Drs. R. Binie, Drs. H. Braakman, PhD students: Drs. S. Aarts, Drs. L. Clerx, Drs. W. van Zwam Drs. M. Fens, Drs. E. de Joode, Drs. M. Hermans, Drs. S. van der Kruijs, drs. B. Dandachi-Fitzgerald, Focus of research: Insight into the prevention, etiology Drs. B. ter Mors, Drs. V. Moulaert, Drs. S. Stappenberg -Klinkenberg, Drs. R. Drijgers. Drs. L. Elias, and treatment of type 2 diabetes and Drs. S. Smeets, Drs. N. Tielemans, Drs. E. Vanhoutte, Drs. M. Vaessen, Drs. R. Handels, Drs. M. Huijts, other chronic diseases and mental Drs. D. van Vliet, Drs. L. Willemstein, Drs. M. Vlooswijk Drs. H. Jacobs, Drs. M. Legra, health Drs. G. Wolters, Focus of research: Chronic epilepsy 20 Drs. N. Vermunt, Drs. S. Vos Focus of research: Cognitive rehabilitation and health 21 Focus of research: Translational research into the early diagnosis of pathological ageing A large scale national biobank, coordinated by MUMC and the VU-MC, formed the infrastructure for translational research into the early diagnosis of pathological ageing (Parelsnoer Neurodegeneratief). Novel diagnostic technology for the early detection of Alzheimer s disease will be examined and evaluated in terms of Health Technology Assessment, i.e., with respect to its added value to existing diagnostic procedures (LeARN, CTMM). A project funded by VSB was started on the prediction of individual trajectories in cognitive disorders. Collaboration with the Department of Neurology and Radiology was intensified, which has led to a new study on neurovascular mechanisms of cognitive disorders, and the interaction between vascular and neurodegenerative mechanisms. Two Kootstra fellowships were obtained (Koehler, Burgmans). Research-Line: P.I.: Determinants of normal, successful and pathological cognitive ageing Dr. M. van Boxtel, Prof. Dr. F. Verhey, Dr. R. van Oostenbrugge, Dr. P. Hofman, Dr. W. Backes, Dr. T. van Berenschot Division staff members supported the initiation of the Maastricht Study (MS), a study to provide more insight into the prevention, etiology and treatment of type 2 diabetes and other chronic diseases and mental health. The MS is a good example of the integrative approach we are aiming at, with input from the departments of Psychiatry & Psychology, Neurology, Neuroradiology, and Neuro-ophtalmology). The central theme of the input from our division is the relation between cognitive function and (silent) cerebrovascular disease in type 2 diabetes, and the application of novel brain imaging methods for the early detection of cognitive dysfunction as well as cerebrovascular disease. A NWO/FES program (0,9Me) was obtained to develop internet-based low-level intervention strategies to support the development of the cognitive ageing process in middle-aged and older adults. service evaluation research. Interventions in cognitive and acquired brain disorders. A stronger focus was put on evidence based neuropsychological interventions, psychosocial interventions, caregiver interventions, cognitive rehabilitation and health service evaluation research. Interventions are investigated in cognitive and acquired brain disorders. Two large grants were received for research in this area. One was received from VSB fonds/zonmw for a research programme on successful psychosocial reintegration of patients and caregivers after stroke. In this programme 4 PhD students (Maastricht, Nijmegen and Utrecht) will investigate the course and predictors of psychosocial functioning, costs of psychosocial care and effectiveness of two new psychosocial interventions for patients and caregivers. The second grant is a NOW/FES Brain & Cognition grant. In this programme the effectiveness of cognitive rehabilitation and factors influencing the success of cognitive rehabilitation will be examined. Research-Line: P.I.: Post doc/ PhD students: Epilepsy/ neuropathy and myotonic dystrophy Prof. Dr. B. Aldenkamp, Dr. M. de Krom, Prof. Dr. H. Vles, Dr. C. Faber The central theme within the research topic Epilepsy is Chronic Epilepsy. This topic is studied in a translational design by means of animal studies, genetic studies (drug resistance), and studies in humans focussed on the impact on cognitive function in chronic epilepsy including brain imaging studies into the early detection of cognitive deterioration. A substantial grant from the National Epilepsy Fund (NEF) was obtained for this programme (led by Prof. Dr. B. Aldenkamp). Research into neuromuscular disorders (led by Dr. C. Faber) targets myotonic dystrophy and neuropathy, with a focus on small fibre neuropathy. In 2010, a formal international cooperation within this later field was established with Prof S. Waxman (Yale University). Furthermore, a PhD funded by the GBS CIDP Foundation International and a grant from a Baxter PNS Fellowship started a study on clinimetric aspects (outcome measures) in Small Fibre Neuropathy (SFN) within a large multi-dimensional international multi-centre collaboration project, captured under the umbrella PeriNomS Inflammatory Peripheral Neuropathy Outcome Measures Standardisation PeriNomS study, small fibre neuropathy (SFN) PeriNomS study). Furthermore, additional funding was obtained from the Talecris Talents programme.

3.2 Division II: Mental Health Division Leader: Prof. Dr. Inez Myin-Germeys Deputy: Dr. Koen Schruers Dr. Maarten Bak Dr. Philippe Delespaul Dr. Rob van Diest Dr. Marjan Drukker Prof. Dr. Eric Griez Dr. Ed Goenenschild Prof. Dr. Peter van Harten Dr. Gunter Kenis Prof. Dr. Andries Korebrits Dr. Tineke Lataster Dr. Richel Lousberg Dr. Machteld Marcelis Dr. Nancy Nicolson Prof. Dr. Jim van Os Dr. Frenk Peeters Dr. Bart Rutten Dr. Jan Schieveld Dr. Jean-Paul Selten Dr. Ruud Severijns Dr. Jacqueline Strik Dr. Wolfgang Viechtbauer Prof. Dr. Marten de Vries Dr. Marieke Wichers Dr. Ruud van Winkel Dr. Franz Wojciechowski Goals & Results As outlined in the SEP protocol, division II Mental Health is 2) A second approach to improve G*E studies, is to improve focusing on gene-environment research in mental health the assessment strategy of environmental exposures in and illness, within a translational context, bringing together relation to live experience (reactive phenotytpes), relevant 22 human and animal components of gene-environment for mental health and resilience. In 2009, workers in divi- 23 interaction research as well as translating these findings to the clinic. The ultimate goal is to identify interactive determinants of reactive phenotypes at the level of lived experience relevant to mental health and resilience. In 2009 and 2010, we worked on the following goals: 1) In order to improve Gene-Environment (G*E) studies searching for the causes of complex diseases such as severe mental disorders, increasingly large sample sizes are urgently required. In 2009, Prof. van Os formed a European Consortium, funded by a large FP7 grant, bringing together 28 European partners to study the influence of G*E in the onset of the prodrome and the first episode of psychosis, the prevalence of psychosis as well as its course over time. The management team of this consortium is situated within Division II, as is the leader of workpackage 7, and collaborators within workpackage 2, 4 and 5. The first data are currently being collected by the 28 partners involved. A large effort has been made to pool together previously collected ESM data, resulting in a large data-set of real-life reactivity data which combined with genetic information offers a unique opportunity for G*E analyses. sion II developed a digital apparatus, the PsyMate, which allows investigating direct person-environment interactions in the realm of daily life lived experience. The software of this apparatus was patented, and it will be further developed for use within the FP7 European G*E study. Currently, the PsyMate is being used in studies of both psychosis and depression. Second, Division II has invested in the development of experimental tasks as tools to study how responses to experimental exposures are moderated by genotype. An experimental task assessing social defeat has been developed. 3) Different biological phenotypes as outcome variables of G*E studies have been identified using MRI, PET, and cortisol paradigms. 4) Complex designs using multimarker analyses require extensive statistical knowledge. Division 2 has invested in the further development of statistical approaches. A statistician has been appointed and close contacts with groups across Europe, Asia and the US have been further developed.

5) Translational studies bringing together basic animal research and patient studies remain a core research line within division II. The translational expert-group has initiated a number of studies, translating human findings to animal models and vice versa. Bart Rutten obtained a VENIgrant to investigate resilience to trauma within a translational context, underscoring the national appreciation of this approach. 6) Finally, the PsyMate is in the process of being tested, in Zon-MW supported trials, in depression and psychosis for therapeutic effects, using feedback derived from information in the reality of daily life. Expert-group: Genetics Coordinator: Dr. R. van Winkel P.I.: Prof. Dr. J. van Os, Dr. B. Rutten, Dr. G. Kenis, Dr. W. Vichtbauer, Dr. M. Drukker, Dr. M. Wichers, Dr. C. Simons PhD students: Drs. D. Collip, Drs. C. Vangeneugten, Drs. M. Van Nierop, Drs. J. Decoster, Drs. N. Geschwind, Drs. C. Lothmann Focus of research: The design of genetic studies in the field of psychiatry as well as investigating the role of genetic variances and gene-environment interactions in the etiology, severity and course of psycho- The management structure of Division II changed in 2009. In april 2009, Dr. Inez Myin-Germeys become the Division 24 leader of Division II. In addition, methodological expert pathology Drs. M. Gevonden, Drs. M. van Winkel, Drs. D. Hernaus 25 groups have been formed, enabling the joining of forces within the division, as well as providing excellent opportunities for training of junior team members. Expert groups on 1) Genetics, 2) Experience sampling, 3) Neuroimaging, 4) Experimental approaches, 5) Epidemiology and Mental Health Services Research, and 6) Translational approaches have been formed. Furthermore, division II welcomed two new full professors. Peter van Harten has become Professor of Movement Disorders in Psychosis. Inez Myin-Germeys has become Professor of Ecological Psychiatry. 3.2.1. Expert groups The genetics expert group coordinates the design of genetic studies in the field of psychiatry as well as the choice of various genetic methodologies, choice of SNPs and genes of interest for the different research lines. Furthermore, it offers a platform for bringing together several disciplines in order to conduct adequately designed, multi-disciplinary and translational research to establish the role of genetic variances and gene-environment interactions in the etiology, severity and course of psychopathology and dimensions of psychological and psychiatric traits. Expert-group: Coordinator: P.I.: Post doc/ PhD students: Experience Sampling Dr. M. Wichers Prof. Dr. I. Myin-Germeys, Dr. T. Lataster, Dr. R. van Winkel, Dr. Ph. Delespaul, Dr. N. Nicolson, Dr. W. Viechtbauer, Dr. N. Jacobs Dr. C. Simons, Drs. T. Driesen, Drs. M. Oorschot, Drs. N. Geschwind, Drs. D. Collip, Drs. R. Kuepper, Drs. J. Lataster, Drs. C. Lothmann, Drs. J. Decoster, Drs. C. van Zelst, Drs. F. Smeets, Drs. I. Kramer, Drs. J. Hartmann, Drs. M. Janssens, Drs. T. Batink. Focus of research: To guard and increase the quality of ESM data collections and analyses, as well as to increase statistical expertise and analytic possibilities The aim of the EXM expertgroup is to guard and increase the quality of ESM data collections and analyses, to examine the validity of the method and the items used in ESM and report on this in international peer-reviewed journals, as well as to increase statistical expertise and analytic possibilities, such as time-series analysis in ESM. Expert-group: Coordinator: P.I.: Collaborators: Post doc/ PhD students: Neuro-imaging Dr. M. Marcelis (psychiatrist) Dr. K. Schruers, Prof. Dr. I. Myin-Germeys, Dr. E. Gronenschild, Prof. Dr. J. van Os, Prof. Dr. E. Griez Dr. A. Roebroeck, Dr. V. van de, Dr. M. van Kroonenburgh, Prof. Dr. R. Goebel, Prof. Dr. K. van Laere, Prof. Dr. F. Mottaghy Drs. P. Habets, Drs. P. Domen, Drs. S. Peeters, Dr. L. Goossens, Drs. D. Collip, Drs. J. Lataster, Drs. R. Kuepper, Drs. N. Leibold, Focus of research: To combine expertise on various neuroimaging modalities (eg. smri, DTI, fmri, PET, MRS) and analysing techniques to examine brain structure and function in psychiatric disorders The expert group Neuro-imaging is a group of researchers that are using various neuroimaging modalities (e.g. smri, DTI, fmri, PET, MRS) and analysing techniques to examine brain structure and function in psychiatric disorders, such as psychotic and anxiety disorder. Our main goals are to examine i) genetic and environmental determinants of brain structure and function in these disorders, ii) neurobiological pathways influencing psychopathology and, iii) neurobiological effects of various therapeutic interventions.

Expert-group: Coordinator: P.I.: Post doc/ PhD students: Experimental Psychopathology Dr. T. Lataster Dr. K. Schruers, Prof. Dr. E. Griez Dr. C. Simons, Dr. L. Goossens, Drs. F. Smeets, Drs. M. Janssens, Drs. A. Shazad, Drs. K. de Cort, Drs. I. Knuts, Drs. D. Collip, Drs. J. Lataster Focus of research: To design novel experimental tasks assessing underlying (neuro)psychological and biological mechanisms that are implicated in the development, course and outcome of psychiatric disorders. Expert-group: Coordinator: P.I.: Post doc/ PhD students: Epidemiology and mental health services research Dr. M. Drukker* Dr. M. Bak, Dr. Ph. Delespaul*, Dr. W. Viechtbauer*, Prof. Dr. J. van Os, Drs. G. Driessen Drs. M. Heins, Drs. E. Deloore, Drs. C. Lothman*, Drs. I. Pipeleers, Drs. F. Smeets*, Drs. M. Oorschot, Dr. N. Gunther, Dr. G. Guilera Focus of research: To discuss the correct use of research methods (epidemiology) and metaanalyses as well as to work on data of patient registers and monitors. This expert group provides support to those researchers 26 designing novel experimental tasks assessing underlying *Active in meta-analysis subgroup approach. (neuro)psychological and biological mechanisms that are 27 implicated in the development, course and outcome of This expert group aims to analyse and develop in correct psychiatric disorders. The focus is on psychotic and affective use of research methods (epidemiology) and meta-analy- disorders. Our goal is to combine these experimental ses. Furthermore, this expert group works on the data of designs with the observational methods (for example the one register (Psychiatric Case Register) and two monitors Experience Sampling Method) that have been developed (Cumulative Needs for Care Monitor and Medication Monitor), within our department in order to improve validity of our as well as on data of healthy children, collected by the studies. youth health care division (YHCD) of the Public Health Service South-Limburg and the Infant Welfare Centre register. Expert-group: Coordinator: P.I.: Post doc/ PhD students: Translational and Cross-species Research Dr. B. Rutten Dr. G. Kenis, Dr. D. van den Hove, Prof. Dr. H. Steinbusch, Prof. Dr. J. van Os, Prof. Dr. K-P. Lesch, Prof. Dr. F. Verhey, Dr. K. Schruers, Dr. P-J. Visser Dr. B.e Machiels, Drs. E. Lambrichts, Drs. O. Peerbooms, Drs. L. Chouliaras, Drs. N. Leibold, Drs. S. Mafi Rad, Drs. C. Hammels, Drs. E. Pischva Focus of research: To support and stimulate innovative projects on translational research questions that require a cross-species The mission of this expert group / team is to support and stimulate innovative projects on translational research questions that require a cross-species approach. The research of its members aims to decipher molecular and cellular pathways that underlie sensitivity and resilience to environmental exposures, and gene-environment interactions in (neuro)psychiatric phenotypes. The ultimate goal is to identify molecular and cellular pathways that are causally involved in the etiologies of psychiatric disorders, to identify biologic markers that predict disease onset and course, to establish the reversibility of neurobiological changes, and to find novel preventive and therapeutic strategies.

3.3 Division III: Neuroscience Division Leader: Prof. Dr. Marc De Baets Deputies: Prof. Dr. Maarten van Kleef Dr. Yasin Temel Dr. Ronald Deumens Dr. Daniel van den Hove Dr. Danilo Gavilanes Dr. Govert Hoogland Dr. Bert Joosten Prof. Dr. Philip van Kerrebroeck Dr. Gommert van Koeveringe Dr. Boris Kramer Dr. Ellen La Heij Dr. Fred van Leeuwen Dr. Mario Losen Dr. Marco Marcus Dr. Piluca Martinez Prof. Dr. Koo van Overbeeke Dr. Jos Prickaerts Prof. Dr. Harry Steinbusch Prof. Dr. Veerle Visser-Vandewalle Prof. Dr. Hans Vles Dr. Lim Lee Wei Goals & Results The Division Neuroscience performs translational research with a strong emphasis on fundamental research. The translational research area can be subdivided into two parts: neurodegeneration and neuroplasticity. The results of the research efforts in division 3 are described by the different Principal investigators and expertise groups. 28 Its mission is to uncover the underlying mechanisms of 29 neurodegenerative and regenerative processes for neurological and psychiatric diseases to improve early diagnosis, health and treatment strategies. Thus, we aim to gain knowledge of physiological and pathophysiological mechanisms underlying affective, cognitive and motor disorders. Within this context, the role of neuroinflammation and pain is also studied as well as their link to developmental disturbances and neuro-urogenital control. Main research topics include cell signalling, brain plasticity, neurodegeneration, regeneration,genetics and epigenetics. Eventually, its aim is to translate relevant scientific findings into new neurotherapies including pharmacotherapy, antibodies or deep brain stimulation. The multidisciplinary staff consists of professionals from relevant disciplines within research and clinic. There are collaborations within world-wide international networks of research offering a strong environment to come up with new neurotherapeutical approaches.

3.3.1 Division III Signal Translation / Neuroplasticity Environment Epigenetics Signal Transduction Experimental Neurosurgery Pain: Transition from acute to chronic pain Modulation of chronic pain Urology 30 Neuroinflammation inflammation Translational neuro- nal transduction in affective processes/disorders, we have base tumours neuraxis, and are considered to be fundamental to the 31 Central Nervous System neuroinflammation Neonatology Epilepsy Alzheimer disease Research lines, staff Research lines: Signal Transduction P.I.: Dr. J. Prickaerts, Dr. Y. Temel, Prof. Dr. H. Steinbusch Post doc: Dr. T. Vanmierlo, Dr. M. van Duinen PhD students: Drs. O. Reneerkens, Drs. E. Bollen, Drs. A Sierksma, Drs. J. De Vry Focus of research: Cellular signal transduction in affective and cognitive processes in health and disease. The major aim is to unravel the mechanism of action of signaling pathways both in health and disease while at the same time exploring the therapeutic potential of key factors in the affected signaling pathway. With respect to sig- discovered that the mechanism of acute tryptophan depletion, which is a tool to challenge the serotonergic system in humans and animals to detect whether it is vulnerable to stress, is very likely not related to serotonin at all (Van Donkelaar et al., 2011). In the field of signal transduction in cognitive processes/disorders it has been shown that phosphodiesterase inhibitors improve memory in rats independently of cerebrovascular effects (Rutten et al., 2009). This is of major importance since this indicates that the second messengers camp and cgmp, which are normally degraded by phosphodiesterases, can be targets for new drugs to improve memory function directly. Recently, a proof of principle study funded by an obtained grant from ZonMW has started investigating the memory improving potential of a specific phosphodiesterase inhibitor in age-related cognitive impaired subjects. Finally, we have succeeded in setting up our unique method of microelectroporation as a non-viral approach for targeted gene delivery in specific brain areas of rodents (De Vry et al., 2010). This approach will be used in future experiments to directly influence the expression of genes implicated in signal transduction in either affective or cognitive processes. For this we received a grant from the Internationale Stichting Alzheimer Onderzoek (ISAO). The results of these studies will help us to find new therapeutic targets for affective and cognitive disorders. Research line: Experimental Neurosurgery P.I.: Dr. Y. Temel, Dr. G. Hoogland, Prof. Dr. V. Visser-Vandewalle and Prof. Dr. H.Steinbusch Post doc: Dr. LW. Lim PhD students: Drs. A. Jahanshahi, Drs. S. Hescham, Drs. M. Janssen, Drs. S. Tan, Drs. H. Vlamings,, Drs. Y. Yakkioui, Drs. D. Zeef Focus of research: Movement disorders and related psychiatric symptoms, biology of skull Our group is continuing to perform both clinical and experimental studies. In this respect, we have conducted studies to improve the surgical therapy for Parkinson s disease patients, by developing novel evaluation methods (saccadometry). In our experimental studies, we mainly focused on developing novel therapies in experimental models of Parkinson s disease (tailored neurostimulation) and Huntington s disease (neurostimulation and gene therapy). These lines of research are supported by grants from the NWO-Veni, Cure Huntington s Disease Intitiative (CHDI, New York, USA), and Hersenstichting Nederland. Research-Line: Transition from acute to chronic pain P.I.: Dr. B. Joosten, Dr. R. Deumens PhD students: Drs. S. van Gorp, Drs. R. Jaken, Drs. S. van Neerven, Drs. L. Knaepen, Drs. M. Theunissen Focus of research: Identification of predictors of chronic pain and investigating approaches aimed at prevention of chronic pain Chronic pain is associated with an enormous socio-economic burden and can result from a plethora of clinical conditions. In our research, we focus primarily on traumainduced neuropathies in the peripheral and/or central nervous system, which are a common cause of chronic pain. The initial pathological events at the site of nerve damage form the drive of pathological events higher up in the establishment of chronic of pain. We aim at understanding the processes of neurodegeneration and regeneration in relation to neuropathic pain. In a recently completed Ph.D. project we found that injury to peripheral nerves induces structural plasticity in the wiring of the spinal nociceptive network, a phenomenon which is likely long-lasting. In a collaboration with UMC Utrecht, we reported on immune-related molecular requirements for chronic pain in animal models of peripheral tissue inflammation and peripheral neuropathy. In two ongoing Ph.D. projects we are investigating predictors of neuropathic pain after spinal cord injury. As a strategy to prevent pain chronification after nerve injury, we aim to provide (1) repair of nerve injuries / damage, (2) immuno-modulatory therapies (Prof. Dr. M. De Baets, Dr. M. Losen, Dr. P. Martinez) and (3) functional training paradigms (e.g. enriched environment). Moreover, we are interested in understanding the pathological events by which pain-related insults during the neonatal period can have long-lasting effects on pain in adulthood (Dr. J. Pawluski, Prof. Dr. H. Steinbusch).

Research-Line: Modulation of chronic pain P.I.: Dr. B. Joosten Post doc: Dr. S. Janssen PhD students: Drs. M. Truin, Drs. H. Smits, Drs. W. Pluijms, Drs. K. van Boxem, Drs. R. Slangen Focus of research: The understanding and application of neuromodulatory techniques, in particular spinal cord stimulation and pulsed radiofrequency, in order to minimize chronic (neuropathic) pain. Pain Syndrome) and the other one in patients with Failed Back Surgery Syndrome (FBSS), both of which provide limited clinical evidence that SCS relieves neuropathic pain. We extend implementation of SCS in other NPP syndromes and designed and completed a pilot study on the clinical effect of SCS in painful diabetic polyneuropathy (PDP). As a follow-up, an RCT (Rachelle Slangen) on the effect of SCS in PDP is currently ongoing. In order to understand the underlying mechanism of action of SCS in PDP a rat model for PDP was developed in the laboratory and the effect of various stimulation parameters was analyzed. It is our intention to study the role of SCS in small fiber neuropathies experimentally as well as clinically in collaboration with Dr. C. Faber (Department of Neurology). From a basic scientific point of view the role of glial cells (as immune-regulatory cells) in the modulation of chronic pain (or plasticity of the nervous system) has our prime interest. Pulsed Radiofrequency as a minimally invasive therapy for treatment of chronic lumbar radicular pain (low back pain) is being studied based on an RCT (Koen van Boxem). In a rat model of lumbar radicular pain, the mechanism of action PRF is being studied. Research Line: Urology P.I.: Dr. G. Van Koeveringe Co investigators: Prof. Dr. J.I. Gillespie, Prof. Dr. Ph. E.BV. van Kerrebroeck, Dr. S.W. de Wachter Post doc: Dr. L. Herfst PhD students: Drs. S. Rahnamai, Drs. B. Biallosterski, Drs. V. Vennemann, Drs. R. Heeringa Focus of research: Neurourology: bladder signalling, control mechanisms and neuromodulation. The Urology Group performs a translational research program Today Spinal Cord Stimulation (SCS) is used in the treatment directed towards fundamental understanding of of intractable neuropathic pain (NPP). Despite the neurogenic and autonomic control mechanisms of the Research Line: Translational neuroinflammation existence of SCS as a pain therapy for over 40 years, up till bladder. The research involves neuronal bladder physiology P.I.: Prof. Dr. M. De Baets, now only two randomized clinical trials (RCT s) have been and pharmacology in relation to the origins of bladder dysfunction. Dr. P. Martinez, Dr. M. Losen and 32 Four projects are ongoing in order to study dif- Dr. P. Molenaar performed: one in patients with CRPS-1(Chronic Regional Research Line: Alzheimer disease; neurodegeneration PhD students: Drs. K. Vrolix, Drs. A. Gomez 33 and posttranslational modifications of Technicians: J. Endert, R. Schneider proteins Focus of research: Defining antigen-specific approaches to P.I.: Dr. F. Van Leeuwen, treatments in neurodegenerative and Prof. Dr. H. Steinbusch neuroimmunological diseases. Post doc: Dr. N. Kholod, Dr. J.-J. Cheng PhD students: Drs. F. Dennissen, Drs. R. Gentier ferent levels of bladder dysfunction in close collaboration with the neuroscience research school, clinical urological department and the Pelvic Care Centre Maastricht. Line 1, funded partly by an NWO-Mozaiek grant and an FP7-ITN Marie Curie EU grant, investigates the role of NO-cyclicG- MP and prostaglandin pathways in the bladder wall in relation to non-voiding activity and its role in the development of the overactive bladder syndrome. Both the NO-cyclicG- MP pathway and the prostaglandin pathway have been shown to play a role in the intrinsic control mechanism in the bladder wall. In addition, the way by which this mechanism is modulated by the central nervous system will be subject of the future afferent recording and tracer studies. Line 2, funded partly by the FP7-ITN Marie Curie EU grant, is a physiological and pharmacological study of non-voiding detrusor activity in animal models representing different mechanisms of diseases affecting bladder control such as a subvesical obstruction guinea pig model, an Alzheimer transgenic mouse model and a decerebrated rat model. The determination of the respective contribution of either bladder or brain/nerve dysfunction to these diseases will contribute to a better understanding of the clinical problems and (patho)physiological mechanisms. Line 3 investigates the perception of bladder sensations in humans and the relationship to voiding behaviour. A relationship of an existing overactive bladder syndrome with non-voiding activity is studied using high-resolution urodynamic measurements. A relationship is sought between psychological profile and the degree of bladder fullness perception.. Line 4 investigates the role of sacral neuromodulation in humans on complaints of overactive bladder and voiding dysfunction. In this research line both working mechanisms (using techniques and models described above) and an optimisation of the current neuromodulation treatment by means of determination of predictive factors and optimisation of techniques are the main subjects to be studied. Parts of the research lines 3 and 4 will be investigated in newly developed and ongoing clinical trials. Focus of research: Protein quality control in Alzheimer s disease. Efficient neuronal function depends on cellular homeostasis. Posttranslational modifications (e.g., ubiquitination) contribute to many functions such as control of short-lived proteins, transcription factors and degradation of aberrant proteins. These homeostatic control mechanisms are often flawed during aging and disease. Our research focuses on quality control mechanisms such as the ubiquitin-proteasome system (UPS). We have discovered that mutant ubiquitin (UBB +1 ) accumulates in the hallmarks of Alzheimer s disease, suggesting that it has a function in this multifactorial disease. Indeed, UBB +1 inhibits the UPS and results in neuronal dysfunction. In the past year we have fully characterized the enzyme Ubiquitin-C-terminal hydrolase L3 that is able to hydrolyse UBB +1 (in collaboration with N.Dantuma, Karolinska Institute, Stockholm, Sweden). In addition, we developed tools (e.g., transgenic animals) to study the effects of UBB +1 in vivo (Fischer et al., 2009, Dennissen et al., 2010). We are currently investigating anatomical (light and immunoelectron microscopy) and behavioral aspects ( e.g., Morris water maze and fear conditioning) in these UBB +1 mice as well as genetic crosses with the Alzheimer mouse model line (APP-Swe/PSEN1, Δ exon9).significantly, interactions between UBB +1 and Aβ plaque formation have already been shown, e.g., plaque load changes. We are working with a broad range of diseases from Myasthenia gravis to, Alzheimer s disease to Schizophrenia. Our goal is to define fine antigen-specificities of individual patients antibodies and their mechanisms of action and/ or individualised treatments based on this new knowledge. The project includes studies of inter-patient heterogeneity in the target autoantigens the autoantibodies and their pathogenic actions and immunological and tissue-specific factors that influence clinical presentation and severity. State of the art technology is used: mature (CD22 + ) B lymphocytes are isolated from peripheral blood or tissue and immortalized with EBV and the polyclonal B cell activator CpG 2006. After immortalization, B cell clones produce monoclonal antibodies. The screening of the antibodies is performed by immunohistochemistry or radioimmunoassay. We also test new approaches to explore the possibilities for treatment: We have demonstrated that Bortezomib

can improve MG symptoms and, therefore, proteasome inhibition is a promising therapeutic strategy to target plasma cells in antibody mediated autoimmune diseases. Research Line: Central Nervous System neuroinflammation P.I.: Dr. P. Martinez, Dr. M. Losen, Prof. Dr. H. Steinbusch, Prof. Dr. M. de Baets Post-doc: Dr. M. Gangolf PhD students: Drs. C. Mencarelli, Drs. G. Bode Focus of research: Understanding neuroinflammation in neurodegenerative diseases. The Epilepsy Research Group aims at translational research by organizing its projects around three central themes, i.e., epileptogenesis, diagnostics, and treatment. Febrile seizures are convulsions brought on by fever in infants and small children. Although the absolute risk remains very small, certain children who have febrile seizures face an increased risk of developing epilepsy. The epileptogenesis research studies the long-term influence of devel- We are studying the role of innate immunity in the pathogenic 34 mechanism involved in neurodegenerative diseases The topics were: 1) Fetal asphyxia (FA); our data support the opmental seizures on neuronal functions. These findings and the involvement of lipids in the early inflammatory prompted a new PhD-study that focuses on long-term 35 process. We are studying the function/dysfunction of danger functional changes of ionotropic receptors of hippocampal signal molecules e.g., Serum amyloid P component and granule cells (collaboration with prof. J-M Rigo and A. Swijs- the ceramide transporter in the neurodegenerative process. en, Hasselt University, Belgium; supported by transnational Moreover we also study the role of these proteins in ER and University Limburg). mitochondrial dysfunction, early pathogenic mechanisms in the neurodegenerative process. Passive immunization with human anti-abeta antibodies is a new therapeutic approach. However recent passive immunization trials have shown some adverse effects. Because antibodies can also exert inflammatory responses, the effector mechanisms of a therapeutic antibody need to be carefully controlled we are studying the contribution of these mechanisms to the therapeutic effect (plaque clearing and improvement of memory function) and possible side effects using pro-inflammatory mouse IgG2a and anti-inflammatory mouse IgG1 antibodies in an AD mouse model Research Line: Neonatology Developmental neuroscience P.I.: Dr. A. Gavilanes, Dr. B. Kramer, Prof. Dr. H. Steinbusch, Prof. Dr. L. Zimmermann, Prof. Dr. J. Vles Kootstra Postdoc: Dr. E Strackx PhD students: Drs.E. Vlassaks, Drs. K. Cox, Drs. R. Jellema, Drs. M. Seehaase, Drs. M. Gantert Associated Researchers: Dr. P. Martínez, Dr. D. van den Hove, Prof. Dr. M. De Baets Focus of research: Asphyxia and inflammation. We focused on the study of the impact of asphyxia and inflammation during fetal and neonatal CNS development. concept that severe FA has a critical role in neurodegeneration and aging. 2) Fetal asphyctic preconditioning; we report the development and characterization of a novel animal model of permanent neuroprotection due to sub-lethal FA. We believe that this model will serve as a useful tool to study the basic mechanisms underlying endogenous neuroprotection. 3) Fetal (LPS) inflammation; we documented for the first time morphological and electrophysiological evidence of a CNS compromise at preterm birth secondary to chorioamnionitis in the sheep. Furthermore, we showed cortical cerebellar changes that might account for the motor and non-motor deficits seen in neonates from compromised pregnancies. E. Strackx defended her PhD thesis, based on the first two described topics, in January 2010. Research Line: Epilepsy P.I.: Dr. G. Hoogland, Dr. M. Majoie, Prof. Dr. A. Aldenkamp, Prof. Dr. J. Vles Post doc: None PhD students: None In collaboration with: Focus of research: Molecular imaging of epileptogenesis. Accumulating evidence suggests that neuromodulation by electric currents can be a treatment option for epilepsy patients. However, the efficacy of this therapy is variable. The treatment research line explores mechanisms by which vagus nerve stimulation (VNS) may exert its antiepileptic effect. In 2011, we completed a PhD-study in which we developed a clinically relevant animal model that is suitable to study VNS-induced changes in the epileptic brain (Rijkers et al., Brain Res. 2010). In a follow-up PhD-study, supported by a Kootstra fellowship from Maastricht university, M. Aalbers is currently studying the role of neuroinflammation in epileptogenesis (in collaboration with dr. A. Vezzani, Mario Negri, Milano, Italy).

36 chapter 4 Facts and figures

Facts and figures 4.1 Earning Power In this section, we present information concerning resources and funding. Direct funding is provided mainly by the MUMC + and comes indirectly from the Dutch Ministry of Education, Culture and Science. Research Funding: funds received in competition from national and international science foundations. Contracts: funds from third parties. Direct Funding at Division level Div. Year Granted organisation Project Amount in e Acquired by 38 1 2009 Maastricht University Kootstra Talent Fellowship* (postdoc) 25.116 S. Köhler 2010 Maastricht University Kootstra Talent Fellowship (postdoc) 25.116 S. Burgmans SUBTOTAL CN&CN 50.232 2 2009 Maastricht University Kootstra Talent Fellowship (postdoc) 25.116 L. Goossens Maastricht University Kootstra Talent Fellowship (postdoc) 25.116 H. Lataster 39 SUBTOTAL 50.232 3 2009 Maastricht University Kootstra Talent Fellowship (PhD-student) 18.381 M. Aalbers Maastricht University Kootstra Talent Fellowship (postdoc) 25.116 Y. Brasnjevic Maastricht University Kootstra Talent Fellowship (PhD-student) 18.381 A. Muris Maastricht University Kootstra Talent Fellowship (postdoc) 25.116 E. Strackx SUBTOTAL 86.994 TOTAL MHeNS 187.458 * Kootstra Talent Fellowships: Awarded by the Faculty Health, Medicine and Life Sciences. Talented future PhD students: The fellowship is meant to bridge the time between graduation of a talented student in Medicine, Health or Life Sciences and the start of an official contract as a PhD-student. Talented future postdocs: The fellowship is meant to bridge the time between graduation of the PhD-student and the start of an official contract as a postdoc.

National Research Funding at Division level Div. Year Granted organisation Project Amount in e Acquired by Div. Year Granted organisation Project Amount in e Acquired by 1 2009 ZonMw Randomized trial on the effects of a 2 2009 NWO NWO-Mozaiek / The Ecogenetics of psychogeriatric diagnostic day hospital 25.000 F. Verhey Connectivity in Schizophrenia 121.090 J. van Os ZonMw Active mobilisation of psychological 2010 NWO-Nationaal Initiatief resources during passive antidepressant Hersenen & Cognitie ReStoRe: a comprehensive 225.000 M. Van Boxtel pharmacotherapy: REsource MObilisation ZonMw rehabilitation research program on Device In Depression (REMOD-ID) 125.000 M. Wichers social reintegration of stroke patients 2010 ZonMw VENI-NWO Grant: and their caregivers 500.000 C. Van Heugten Moving from vulnerability to resilience: NWO-Nationaal Initiatief shaping the bodily and psychological Hersenen & Cognitie Cognitieve Revalidatie 175.000 C. Van Heugten ability to withstand life adversity. 250.000 B. Rutten NWO-Nationaal Initiatief Hersenen & Cognitie Cognitieve Revalidatie 25.000 C. Van Heugten SUBTOTAL MENTAL HEALTH 496.090 40 ZonMw Knoop in je zakdoek: Cognitieve revalidatie voor hersenletsel patienten 3 2009 ZonMw VENI-NWO Grant: 41 met milde cognitieve problemen. 31.974 C. Van Heugten The role of immunoglobulin G4 in ZonMw VENI-NWO Grant / autoimmunity against cell membrane Functional MRI biomarkers of cognitive receptors 250.000 M. Losen decrements in diabetes. 250.000 J. Jansen 2010 ZonMw ZonMw: Predictive validity of phosphodiesterase SUBTOTAL CN&CN 1.231.974 type 4 inhibition for cognitive improvement: a translational behaviour-eeg approach. 264.201 J. Prickaerts SUBTOTAL NEUROSCIENCE 514.201 TOTAL MHeNS 1.010.291

National and International Reviewed Funding at Division level Div. Year Granted organisation Reviewed Project Amount in e Acquired by Dep. Year Granted organisation Reviewed Project Amount in e Acquired by 1 2009 Alzheimer Nederland PR* Diverse projecten 80.000 F. Verhey 3 2009 ISAO PR BDNF: the bridge between depression Alzheimer Nederland PR Vroegdiagnostiek bij dementie 231.667 F. Verhey and Alzheimer s disease 100.000 J. Prickaerts Alzheimer Nederland PR Vroegdiagnostiek bij dementie 231.667 F. Verhey ISAO PR Insulin dysregulation as precursor Alzheimer Nederland PR Vroegdiagnostiek bij dementie 55.000 F. Verhey to Alzheimer s disease 50.000 E. Van Donkelaar 2010 Alzheimer Nederland PR Diverse projecten 80.000 F. Verhey ISAO PR A protective effect of misframed ISAO PR Blood-brain barrier permeability in ubiquitin on AB plaque load in AD 150.000 F. Van Leeuwen Alzheimer s disease 50.000 S. Burgmans ISAO PR Development of analogues of Nationaal Epilepsie Fonds PR Local axonal architecture and new drug dimebon. 100.000 T. Strekalova spontaneous dynamic BOLD ISAO PR Mechanism of oxidative stress in fluctuations in bottom-of-sulcusdysplasia: Alzheimer s disease 100.000 H. Steinbusch/ a model of cryptogenic Y. Park location related seizurs. 34.674 P. Hofman Hersenstichting Nederland PR Hersenstichting 2009(2)-26 42 GBS Foundation PR GBS: Perinoms study 11.251 K.Faber/ Hersen pacemaker voor depressie ; I.Merkies 43 SUBTOTAL CN&CN 774.259 2 2009 ISAO PR DNA methylation in Alzheimer s disease 48.870 B. Rutten ECNP Non PR** ECNP Research Grant for Young Scientists 40.000 K. Schruers Mondriaan Zorggroep Non PR Onderzoekssamenwerking Mondriaan/ Psychiatrische Epidemiologie 59.000 J. van Os VWS Non PR Mental Health Case Register (PCR-Zuid-Limburg) 118.000 J. van Os 2010 VWS Non PR Mental Health Case Register (PCR-Zuid-Limburg) 120.999 J. van Os Mondriaan Zorggroep Non PR Onderzoekssamenwerking Mondriaan/ Psychiatrische Epidemiologie 59.000 J. van Os GGZ Non PR Samenwerkingsovereenkomst Regionale Zorgmonitor GGZ. 40.000 Ph. Delespaul European Union PR EU-GEI Management Coördinator / OZ deel Maastricht 1.158.460 J. van Os SUBTOTAL MENTAL HEALTH 1.644.329 neuronale mechanismen van elektrische hersenstimulatie in diermodellen van depressie. 35.000 Y. Temel European Commission PR European Master in Neuroscience 265.121 H. Steinbusch CHDI Foundation, Inc. PR Deep Brain Stimulation in a Transgenic Rat Model of Huntington s Disease 163.949 Y. Temel 2010 ISAO PR ISAO OW 2010 30.000 H. Steinbusch ISAO PR Temel/Memory enhancement by deep brain stimulation in experimental Alzheimer s disease. 100.000 Y. Temel AFM PR Role of the central anchoring protein rapsyn in myasthenia gravis and its experimental animal model. 29.000 M. De Baets Stichting MS Research PR Tryptophan enriched diets to improve mood and co gnitive function in multiple sclerosis 48.707 C. Lieben *PR = peer-reviewed / ** Non-PR = non-peer-reviewed SUBTOTAL NEUROSCIENCE 1.171.777 TOTAL MHeNS 3.590.365

Contract Funding Div. Year Granted organisation Project Amount in e Acquired by 1 2010 Bristol-Myers Squibb BMS Visser. 165.000 P.J. Visser SUBTOTAL CN&CN 165.000 2 2010 SWOL PhD project 250.000 P. Van Harten SUBTOTAL MENTAL HEALTH 250.000 4.2 Research staff Research staff input at School level (n fte/year) Position 2009 2010 Senior Research staff inclusive external funding Tenured staff 18,6 18,9 Non- tenured staff 25,6 25,6 Subtotal senior research staff 44,2 44,4 3 2009 Talecris Biotherapeutics, Inc. Peripheral Neuropathy Outcome Measures PhD students* 44,7 45,9 Standardisation (PeriNomS) Study 147.975 K. Faber inclusive external funding Intra-Cellular Therapies, Inc. Intra Cellular Therapies (ICT) 46.080 J. Prickaerts University of Girona Study of the gene expression inducef Total research staff 88,9 90,3 44 after STN-DBS, a technique used in the treatment of Parkinson disease 3.939 Y. Temel Supporting staff 23,5 23,7 45 2010 EnVivo Pharmaceuticals, Inc. EnVivo 75.800 J. Prickaerts SUBTOTAL NEUROSCIENCE 273.794 TOTAL MHeNS 688.794 Total staff 112,4 114,0 *PhD students form an important part of the workforce of the School; in 2011 there were...present (Annex 2) Research staff input at Cognitive Neuropsychiatric & Clinical Neuroscience (n fte/year) Position 2009 2010 Senior Research staff inclusive external funding Tenured staff 6,4 6,4 Non- tenured staff 8,0 9,2 Subtotal senior research staff 14,4 15,6 PhD students 12,5 14,5 inclusive external funding Total research staff 26,9 30,1 Supporting staff 5,5 5,7 Total staff 32,4 35,8

Research staff input at Mental Health (n fte/year) Position 2009 2010 Senior Research staff inclusive external funding Tenured staff 6,2 6,3 Non- tenured staff 6,3 6,8 Subtotal senior research staff 12,5 13,1 PhD students 9,3 10,2 inclusive external funding Total research staff 21,7 23,3 Supporting staff 9,5 9,6 46 Total staff 31,2 32,9 Research staff input at Neuroscience (n fte/year) Position 2009 2010 Senior Research staff inclusive external funding Tenured staff 6,0 6,2 Non- tenured staff 11,4 11,4 Subtotal senior research staff 17,4 17,6 PhD students 22,9 21,2 inclusive external funding chapter 5 Output results Total research staff 40,2 38,8 Supporting staff 8,5 8,4 Total staff 48,7 47,2

5.1 Output results of the School This overview presents the output, expressed as peer reviewed publications. The full list of publications are reported at our website (publicationss MHeNS 2009-2010). In chapter 5.2 the best 5 publications per year, per division are listed illustrating the core research. In addition the overview below shows the number of PhD-theses. A full list of PhD-theses is listed in chapter 5.3. Academic publications in refereed* journals 2009 2010 Division Cognitive Neuropsychiatry & Clinical Neuroscience 171 194 Division Mental Health 75 115 Division Neuroscience 15 153 Total 361 462 48 PhD theses 31 22** * Refereed journals: papers in academic journals that employ an anomynous peer referee system. ** Difference with numbers in chapter 5.3 is due to parttime appointments at other FHML Schools. 49 5.2 Best Publications 2009 2010 Division Cognitive Neuropsychiatry & Clinical Neuroscience 2009 1. Wolfs, C. A., Dirksen, C. D., Kessels, A., Severens, J. L., & Verhey, F. R. (2009). Economic evaluation of an integrated diagnostic approach for psychogeriatric patients: results of a randomized controlled trial. Arch Gen Psychiatry, 66(3), 313-323 (IF 14.2) 2. Visser, P. J., Verhey, F., Knol, D. L., Scheltens, P., Wahlund, L. O., Freund-Levi, Y., Tsolaki, M., Minthon, L., Wallin, A. K., Hampel, H., Burger, K., Pirttila, T., Soininen, H., Rikkert, M. O., Verbeek, M. M., Spiru, L., & Blennow, K. (2009). Prevalence and prognostic value of CSF markers of Alzheimer s disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol, 8(7), 619-627 (IF 14.2) 3. Staals, J., van Oostenbrugge, R. J., Knottnerus, I. L., Rouhl, R. P., Henskens, L. H., & Lodder, J. (2009). Brain microbleeds relate to higher ambulatory blood pressure levels in first-ever lacunar stroke patients. Stroke, 40(10), 3264-3268 (IF 6.5) 4. Bakkers M., Merkies I. S., Lauria G., Devigili G., Penza P., Lombardi R., Hermans M. C., van Nes S. I., De Baets M., Faber C. G. (2009) Intraepidermal nerve fiber density and its application in sarcoidosis. Neurology 73(14): 1142-8. (IF 7.043) 5. Burgmans, S., van Boxtel, M. P., Smeets, F., Vuurman, E. F., Gronenschild, E. H., Verhey, F. R., Uylings, H. B., & Jolles, J. (2009). Prefrontal cortex atrophy predicts dementia over a six-year period. Neurobiol Aging, 30(9), 1413-1419 (IF 6.0)

2010 Divisie Neuroscience 1. Vlooswijk, M. C., Jansen, J. F., de Krom, M. C., Majoie, H. M., Hofman, P. A., Backes, W. H., & Aldenkamp, A. P. (2010). Functional MRI in chronic epilepsy: associations with cognitive impairment. Lancet Neurol, 9(10), 1018-1027 (IF 18.126) 2009 2. Knottnerus, I. L., Govers-Riemslag, J. W., Hamulyak, K., Rouhl, R. P., Staals, J., Spronk, H. M., van Oerle, R., van Raak, E. P., 1. Brasnjevic I., Steinbusch H. W., Schmitz C., Martinez-Martinez P. (2009) Delivery of peptide and protein drugs over the Lodder, J., ten Cate, H., & van Oostenbrugge, R. J. (2010). Endothelial activation in lacunar stroke subtypes. Stroke, 41(8), blood-brain barrier. Prog Neurobiol 87(4): 212-51. (IF 9.13) 1617-1622 (IF 7.041) 2. Rutten K., Van Donkelaar E. L., Ferrington L., Blokland A., Bollen E., Steinbusch H. W., Kelly P. A., Prickaerts J. H. (2009) 3. Vaessen, M. J., Hofman, P. A., Tijssen, H. N., Aldenkamp, A. P., Jansen, J. F., & Backes, W. H. (2010). The effect and reproducibility Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in of different clinical DTI gradient sets on small world brain connectivity measures. Neuroimage, 51(3), 1106-1116 rats. Neuropsychopharmacology 34(8): 1914-25. (IF 6.835) (IF 5.739) 3. Truin M., van Kleef M., Verboeket Y., Deumens R., Honig W., Joosten E. A. (2009) The effect of Spinal Cord Stimulation 4. Ramakers, I. H., Visser, P. J., Aalten, P., Kester, A., Jolles, J., & Verhey, F. R. (2010). Affective symptoms as predictors of in mice with chronic neuropathic pain after partial ligation of the sciatic nerve. Pain 145(3): 312-8. (IF 6.03) Alzheimer s disease in subjects with mild cognitive impairment: a 10-year follow-up study. Psychol Med, 40(7), 1193-1201 (IF 4. Vanmierlo T., Rutten K., Dederen J., Bloks V. W., van Vark-van der Zee L. C., Kuipers F., Kiliaan A., Blokland A., Sijbrands E. 5.012) J., Steinbusch H., Prickaerts J., Lutjohann D., Mulder M. (2009) Liver X receptor activation restores memory in aged AD 5. Burgmans, S., van Boxtel, M. P., Vuurman, E. F., Evers, E. A., & Jolles, J. (2010). Increased neural activation during picture mice without reducing amyloid. Neurobiol Aging (IF 5.959) encoding and retrieval in 60-year-olds compared to 20-year-olds. Neuropsychologia, 48(7), 2188-2197 (IF 4.345) 5. Kreczmanski P., Heinsen H., Mantua V., Woltersdorf F., Masson T., Ulfig N., Schmidt-Kastner R., Korr H., Steinbusch H. W., Hof P. R., Schmitz C. (2009) Microvessel length density, total length, and length per neuron in five subcortical regions in schizophrenia. Acta Neuropathol 117(4): 409-21. (IF 5.31) 50 Divison Mental Health 51 2009 1. van Os, J. and S. Kapur (2009). Schizophrenia. Lancet 374(9690): 635-45. (IF 28.409) 2. Simons, C. J., D. K. Tracy, et al. (2009). Functional Magnetic Resonance Imaging of Inner Speech in Schizophrenia. Biol Psychiatry. (IF 8.672) 3. Dominguez, M. D., M. Wichers, et al. (2009). Evidence That Onset of Clinical Psychosis Is an Outcome of Progressively More Persistent Subclinical Psychotic Experiences: An 8-Year Cohort Study. Schizophr Bull. (IF 7.467) 4. Myin-Germeys, I., M. Oorschot, et al. (2009). Experience sampling research in psychopathology: opening the black box of daily life. Psychol Med 39(9): 1533-47 (IF 4.718) 5. Goossens, L., J. Kukolja, et al. (2009). Selective processing of social stimuli in the superficial amygdala. Hum Brain Mapp 30(10): 3332-8.(IF 6.256) 2010 1. van Os J, Kenis G, Rutten BP (2010). The environment and schizophrenia. Nature, 468, 203-12. (IF 34.480) 2. van Winkel R; Genetic Risk and Outcome of Psychosis (GROUP) Investigators (2010). Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up. Archives of general Psychiatry, [Epub ahead of print] (IF 12.257) 3. Henquet C, van Os J, Kuepper R, Delespaul P, Smits M, Campo JA, Myin-Germeys I. (2010). Psychosis reactivity to cannabis use in daily life: an experience sampling study. Br J Psychiatry, 196, 447-53. (IF 5.777) 4. Wichers M, Geschwind N, van Os J, Peeters F. (2010). Scars in depression: is a conceptual shift necessary to solve the puzzle? Psychol Med, 40, 359-65. (IF 5.012) 5. Habets P, Marcelis M, Gronenschild E, Drukker M, van Os J; for G.R.O.U.P (2010). Reduced Cortical Thickness as an Outcome of Differential Sensitivity to Environmental Risks in Schizophrenia. Biol Psychiatry, [Epub ahead of print]. (IF 8.926) 2010 1. Chouliaras, L., Rutten, B. P., Kenis, G., Peerbooms, O., Visser, P. J., Verhey, F., van Os, J., Steinbusch, H. W., van den Hove, D. L. (2010). Epigenetic regulation in the pathophysiology of Alzheimer s disease. Prog Neurobiol, 90(4), 498-510 (IF 9.14) 2. Basar, K., Sesia, T., Groenewegen, H., Steinbusch, H. W., Visser-Vandewalle, V., Temel, Y. (2010). Nucleus accumbens and impulsivity. Prog Neurobiol, 92(4), 533-57 (IF 9.14) 3. Vry, J. D., Martinez-Martinez, P., Losen, M., Bode, G. H., Temel, Y., Steckler, T., Steinbusch, H. W., Baets, M. D., Prickaerts, J. (2010). Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain. Mol Ther, (IF 6.239) 4. J ahanshahi, A., Vlamings, R., Kaya, A. H., Lim, L. W., Janssen, M. L., Tan, S., Visser-Vandewalle, V., Steinbusch, H. W., Temel, Y. (2010). Hyperdopaminergic status in experimental Huntington disease. J Neuropathol Exp Neurol, 69(9), 910-7 (IF 4.564) 5. van Neerven, S., Joosten, E. A., Brook, G. A., Lambert, C. A., Mey, J., Weis, J., Marcus, M. A., Steinbusch, H. W., van Kleef, M., Patijn, J., Deumens, R. (2010). Repetitive intrathecal VEGF(165) treatment has limited therapeutic effects after spinal cord injury in the rat. J Neurotrauma, 27(10), 1781-91 (IF 4.252)

5.3 PhD -theses 2009 2010 Division CN & CN 2009 Baars M.A.E. Epidemiological studies into prodromes and risk factors for cognitive decline and dementia Promotor: Prof.dr. J. Jolles; Prof.dr. F.R.J. Verhey Co-promotor: Dr. M.P.J. van Boxtel Bootsma H.P. Hoogenhout E.M. New anti-eleptic drugs in pharmacoresistant epilepsy; retention Perceived cognitive problems in young old adults : contex- Esquivel G. time as outcome parameter tual factors, assessment and intervention With the body in mind; the role of exercise and acid-base bal- Promotor: Prof.dr. A.P. Aldenkamp; Prof.dr. Y.A. Hekster Promotor: Prof.dr. J. Jolles ance in panic Co-promotor: Dr.ir. J.A.R.J. Hulsman Winkens I. Co-promotor: mw.dr. R. Groot; Dr, W. v.d. Elst Promotor: Prof.dr. E.J.L. Griez 52 Mental slowness after stroke: assessment and treatment Co-promotor: Dr. K.R.J. Schruers 53 Bouwens S.F.M. Ecological aspects of cognitive assessment Promotor: Prof.dr. F.R.J. Verhey Co-promotor: Dr. C.M. van Heugten Braek D. in de Attention dysfunction and ADHD in adults: determinants and interventions Promotor: Prof.dr. J. Jolles Co-promotor: Dr. J. Dijkstra Deursen J.A. van Functional and structural brain markers of Alzheimer s disease: clinical studies using EEG and VBM Promotor: Prof.dr. W. Riedel; Prof.dr. F.R.J. Verhey Co-promotor: Dr. E.F. Vuurman Nicolai J. Non-convulsive aspects of epilepsy in children Promotor: Prof.dr. A.P. Aldenkamp / Prof.dr. J. Vles Co-promotor: Dr. J.B.A.M. Arends Vlaar A.M. Transcranial duplex scanning in parkinsonian disorders comparison with SPECT Promotor: Prof.dr. W.H. Mess Co-promotor: Dr. W.E.J. Weber; Dr. S.C. Tromp; Dr. M.J. van Kroonenburgh Promotor: Prof.dr. D.T. Wade; Prof.dr. L. Fasotti Co-promotor: Dr. C.M. van Heugten Division CN & CN 2010 Bol Y. Understanding fatigue in multiple sclerose Promotor: Prof.dr. F.R.J. Verhey; Prof.dr. R.M. Hupperts; Prof. dr. J.W. Vlaeyen Co-promotor: Dr. A.A. Duits Bour A. Cognition and depression after stroke; course and interaction Promotor: Prof.dr. F.R.J. Verhey; Prof.dr. M. Limburg Co-promotor: Dr. S.M.C. Rasquin Caroli A. Multimodal analysis of neuroimages in alzheimer s disease Promotor: Prof.dr. F.R.J. Verhey Co-promotor: Dr. A. Remuzzi; Dr. G.B. Frisoni Hobbelen H. Paratonia enlightened: definition, diagnosis, course, risk factors and treatment Promotor: Prof.dr. R.A. de Bie; Prof.dr. F.R.J. Verhey; Prof.dr. Co-promotor: R.T.C.M. Koopmans Keulers E.H.H. The adolescent brain: neurocognitive development and subject - related factors Promotor: Prof.dr. J. Jolles Co-promotor: Dr. P. Stiers Reijnders J.S.A.M. Mood and motivation in parkinsons disease Promotor: Prof.dr. F.R.J. Verhey Co-promotor: Dr. A.F.G. Leentjens; Dr. W.E.J. Weber Smeets F. Cognitive aging and functional compensation evidence from brain imaging studies Promotor: Prof.dr. J. Jolles Co-promotor: Dr. E. Vuurman; Dr. M. van Boxtel Cavedini P. Decisional processes in obsessive-compulsive spectrum disorders. From neuropsychology to clinical implications Promotor: Prof.dr. E.J.L. Griez Co-promotor: Prof.dr. G.P., Milan Perna Dominguez. M. A dynamic model of the onset of clinical psychosis from an epidemiological perspective. Promotor: van Os Co-promotor: Dr. Krabbendam; Dr. Wichers Glaser J.P. Stress reactivity in borderline personality disorder Promotor: Prof.dr. J. van Os Co-promotor: Dr. I. Myin-Germeys Goossens L. The threatened brain: magnetic resonance imaging studies into fear and panic Promotor: Prof.dr. E.J.L. Griez Co-promotor: Dr. K.R.J. Schruers; Dr. S. KU Sunaert Jabben N.E.J.G. Exploring neurocognition across the psychosis continuum Promotor: Prof.dr. J. van Os Co-promotor: Dr. L. Krabbendam Moresi S.M.J. Preparing for action; a behavioral and pupillometric study Promotor: Prof.dr. J. Jolles; Prof.dr. H. Kuipers Co-promotor: Dr.J. Adam; Dr.P. van Gerven Burgmans S. Linking cognitive and cerebral aging, evidence from structural and functional MRO Promotor: Prof.dr. J. Jolles; Prof.dr. H.B.M. Uylings Co-promotor: Dr.M.P.J. van Boxtel; Dr. E.F.P.M. Vuurman Division Mental Health 2009 Allardyce J.G.S. Epidemiological studies of Schizophrenia Promotor: Prof.dr. J. van Os Kohler S. Psychopathology and ageing; towards a better understanding of psychosis and depression in later life Promotor: Prof.dr. F.R.J. Verhey /Prof.dr. J. van Os

Lardinois M.J.H. Why stress causes psychosis and psychosis causes stress Promotor: Prof.dr. J. van Os Co-promotor: Dr. I. Myin-Germeys Lataster H.W.G. On the pathway from stress to psychosis Promotor: Prof.dr. J. van Os Co-promotor: Dr. I. Myin-Germeys Division Mental Health 2010 Domschke K. Genetic determinants of emotional processing in anxiety Donkelaar E. van Kreczmanski P. and depression - some implications for treatment response Challenging the serotin system Neuropathology of Schizophrenia : a new vistas Promotor: Prof.dr. E.J.L. Griez Promotor: Prof.dr. H.W.M. Steinbusch Promotor: Prof.dr. H.W.M. Steinbusch Brunner F.V.J. 54 Co-promotor: Dr. J. Prickaerts; Dr. P.A.T. Kelly; Dr. A. Blokland Co-promotor: Dr. C. Schmitz Prognosis in complex regional pain syndrome 55 Gorini A. Virtual Worlds, Real Healing Promotor: Prof.dr. E.J.L. Griez Co-promotor: Dr. K. Schruers Rossum I. van Onset, course and comorbidity of bipolar symptoms and treatment setting Prof.dr. J. van Os Co-promotor: Dr. T. Tenback Simons C.J.P. In search of neurobiological intermediate phenotypes of aberrant information processing in psychosis Promotor: Prof.dr. J. van Os; Prof.dr. W. Riedel Co-promotor: Dr. L. Krabbedam Vossen H.G.M. Cortical processing of pain: a bridge between experimental findings and clinical implications Promotor: Prof.dr. J. van Os; Prof.dr. H. Hermens Co-promotor: Dr. R. Lousberg Versmissen D.J.G. On social Cognition: Vulnerability and symptoms in Psychosis Promotor: Prof.dr. J. van Os Co-promotor: Dr.L. Krabbendam Division Neuroscience 2009 Beuken M. v.d. Symptoms in Patients with cancer Promotor: Prof.dr. M. van Kleef; Prof.dr. H.C. Schouten Co-promotor: Dr. J. Patijn; Dr. J.M. de Rijke Foecking M. Identification and Characterisation of stress-regulated proteins in the central nervous system in vivo and in vitro studies on rodents Promotor: Prof.dr. H.W.M. Steinbusch Co-promotor: Prof.dr. D.R. Cotter Gabriel A.F. Effect of housing in an enriched environment on the recovery from experimental inflammatory pain Promotor: Prof.dr. M. Marcus Co-promotor: Dr. E. Joosten Grol S. The intersitial cells of the urinary bladder Promotor: Prof.dr. P.E.V.A. van Kerrebroeck Co-promotor: Dr. G.A. van Koeveringe; Prof.dr. J.I.Gillespie Hoff E.I. Vascular cognitive impairment and cholinergic function26-3-2009 an integrative analysis in rat brain. Promotor: Prof.dr. H.W.M. Steinbusch; Prof.dr. M. Limburg Co-promotor: Dr. R.J. van Oostenbrugge; Dr. R.M. Dijkhuizen Jongh R. de Modulation and Adaption in the Normal and Obstructed Urinary Bladder. Promotor: Prof.dr. Ph.E.V. van Kerrebroeck Co-promotor: Dr. G.A. van Koeveringe; Prof.dr. J.I. Gillespie Lim Lee Wei The periaqueductal gray and defensive behavior: new clues from an old concept Promotor: Prof.dr. H.W.M. Steinbusch; Prof.dr. V. Visser- Vandewalle Co-promotor: Dr. Y. Temel; Dr. A. Blokland Meulen ter P.H. Injection therapy for stress urinary incontinence in adult women Promotor: Prof.dr. Ph.E.V.A. van Kerrebroeck Co-promotor: Dr. L.C.M. Berghmans Phernambucq M.A. New approaches for immune modulation in Myasthenia Gravis Promotor: Prof.dr. M.H. de Baets Co-promotor: Dr. M.R. Losen; Dr.P. Martinez-Martinez Renterghem C. van The clinical value of TURP in patients with elevated or rising PSA Promotor: Prof.dr. Ph. van Kerrebroeck Co-promotor: Dr. G. van Koeveringe Division Neuroscience 2010 Brasnjevic I. Moleclar and cellular alterations in the aging and Alzheimer s disease brain: implications for therapeutic and preventative strategies Promotor: Prof.dr. H.W.M. Steinbusch Co-promotor: Dr. B. Rutten Promotor: Prof.dr. M. van Kleef Co-promotor: Prof.dr. L.M. Bachman Jaken R.J.P. Neurophatic pain: glial responses and plasticity in the spinal nociceptive network Promotor: Prof.dr. M. Marcus Co-promotor: Drs. R. Deumens; Dr. E. Joosten Schreiber J. The quest for the origin and prevention of postoperative myalgia following syccinylcholine new insights in an old problem Promotor: Prof.dr. M. van Kleef; Prof.dr. M.A.E. Marcus; Prof. dr.t. FuchsBuder Sesia T. The nucleus accumbens: stimulate your impulse Promotor: Prof.dr. H.W.M. Steinbusch; Prof.dr. V. Visser-van de Walle Co-promotor: Dr. Y. Temel

Stanescu D.M. Pax6 in mammalian degenerative retina Promotor: Prof.dr. F. Hendrikse; Prof.dr. J.P.M. Geraedts Strackx E. Fetal asphyxia: Fried of foe? Promotor: Prof.dr. J.S. Vles; Prof.dr. L.J. Zimmermann Co-promotor: Dr. A.W. Gavilanes Vanmierlo T. Brain sterol metabolism - modulating alzheimer s disease Promotor: Prof.dr. H.W.M. Steinbusch Co-promotor: Dr. M. Mulder; Prof.dr. D. Lütjohann 56 Veen R. van der Macular pigment; in the healthy and diseased retina Promotor: Prof.dr. F. Hendrikse Co-promotor: Dr. T.T.J.M. Berendschot chapter 6 Master and PhD Educational Activities

6.1 Master Programme Involvement of MHeNS in Master programs Research Master in Cognitive and Clinical Neuroscience MHeNS has an active participation in the interfaculty Research Master (RM) Cognitive and Clinical Neuroscience, that received its accreditation by NVAO/KNAW in 2004 (reaccreditated in 2009). This two-year RM program has four specializations: 1) Cognitive Neuroscience, 2) Neuropsychology, 3) Psychopathology and 4) Fundamental Neuroscience. The RM is an interfaculty program of the FPN (which acts as coordinating Faculty) and the FHML. MHeNS provides teaching staff to tracks 2, 3 and 4, as well as the coordinators of track 3 and 4, Dr. N. Nicolson and Dr. J. Prickaerts, respectively. The program is internationally oriented and all courses are given in English. Students become acquainted with the most important theories, models, techniques, and analytic methods that are used in their respective specialization. The program stimulates scientific insight and a critical attitude through active participation in the form of discussions, presentations, and papers. The curriculum includes theoretical courses, colloquia, skill trainings, and workshops followed throughout year 1 and the first half of year 2. In addition, and in order to broaden overall knowledge of this rapidly developing interdisciplinary field, students follow the lecture series Interdisciplinary Perspectives. In year 2, students from all four specializations conduct their own research project and thereafter report it in the form of a master s thesis. Students following the specializations Psychopathology or Neuropsychology follow in addition, a 13-week clinical internship in an approved setting. The clinical internship can be conducted in conjunction with the research internship, or as a separate activity. The Research Master program is equivalent to 120 European credits. MHeNS is involved in the curricula of several regular and Research Master programs of FHML and FPN. MHeNS, all three divisions participate in the Research Master Cognitive and Clinical Neuroscience, a joint Research Master between FHML and FPN. In addition, Division 2 co-organizes the International Post-Master program Affective Neuroscience. Furthermore MHeNS, particularly Division 3, is involved in the master Clinical Molecular Sciences of the Transnational University Limburg (School Post Master Program Affective Disorder of Life Sciences). Finally, MHeNS, particularly Division 2, is The Universities of Maastricht and Florence, the Psychopharmacology involved in the 4 year Research Master Arts Klinisch Unit of Bristol University, and the Sackler Onderzoeker (A-KO) of FHML. School of Medicine (Tel Aviv) organize a joint postgraduate 58 program, which leads towards an International Master De- 59 gree in Affective Neuroscience. This is a two-year, part time curriculum, for holders of a degree in medicine, psychology or a related discipline. This high-profile master is aimed at research-minded clinicians who want to develop their research skills and scientific knowledge in the field of anxiety and depression. The program emphasizes a scientific approach and gives insights and theoretical knowledge on epidemiology, neurobiology, clinical and experimental psychology. Prof. Dr. Eric Griez of Division 2 is chairman of the Board of Directors of this Master program. The Master of Affective Neuroscience was accredited as a post-initial Master s program by the NVAO in 2008. The first year consists of an intensive residential course and requires the candidate to conduct an approved research project under supervision of a mentor in one of the institutes that is connected to the network. In the second year, candidates attend a second intensive residential course and a one-week series of top seminars. Furthermore, they complete their research project by writing and defending a dissertation. Throughout the curriculum students are supported by e-workshops. The program is largely tailored to individual needs by means of a personal portfolio for each candidate, in accordance with the MUMC+ standards. Af-

ter the second year, successful candidates are entitled to a Master Degree in Affective Neuroscience, jointly awarded by the Universities of Maastricht and Florence. Master Clinical Molecular Sciences Staff members of in particular the division 3 participate with lectures and seminars in several courses (e.g. courses 1.1 and 1.2) of the 2-year Master Clinical Molecular Sciences of the School for Life Sciences. Additionally, junior internships (4 months, first year) and senior internships (8 months, second year) within MHeNS are offered to students in this master program. This master program trains students to become molecular biologists. Arts Klinisch Onderzoeker (A-KO). This master is open for biomedical bachelor students, who are trained to become both a medical doctor and clinical researcher. A-KO researchers can serve as a bridge between health care and research. They can translate health care issues to scientific research and, on the other hand, apply research findings in daily health care. Internships are offered for this master program within the MHeNS divisions. European Master in Neuroscience MHeNS will apply for accreditation of a joint Master program European Master in Neuroscience (EMN) in 2011-2012 in collaboration with the University of Hasselt. Prof. Dr. Harry Steinbusch (Director), Prof. Dr. Jörg Mey (Program coordinator) and Dr. Nicole Senden (Managing Director) constitute the developing committee of EMN. Their goal is to cluster knowledge and expertise from different universities and countries in order to be able to offer specialised training. This network will result in more qualified teachers in all the specialist fields and will attract high quality Master students. The collaboration with scientific partners in the Euregion, i.e. Hasselt, Aachen, and Liège, will be strengthened in this Master EMN. Focus is on acquiring the molecular biological, neuroanatomical, electrophysiological, and behavioural techniques necessary for preclinical basic biological research. 6.2 PhD Programme In order to encourage MHeNS PhD candidates to take advantage of the diverse educational offerings available at the local, national, and international level, up-to-date links to course information are compiled on the MHeNS website ( PhD Courses ). In 2009 and 2010, many MHeNS PhD candidates again took advantage of the opportunity to attend the generic PhD courses offered by Maastricht University and the specific highly-rated, in-depth workshops and courses From? University), Drugs and the Brain: An Update in Psychopharmacology (collaboration Maastricht University and the University of Minho, Braga, Portugal), Stereotaxy: from local drug delivery to deep brain stimulation (Maastricht University) and Gene-environment interactions in Psychiatry (Maastricht University). Others followed more specialized Euron courses or courses offered by one of the MHeNS divisions, such as the Experience Sampling workshop that is given twice each year by Division II (Mental Health). To foster interaction and research collaboration across the three MHeNS divisions, the new full-day PhD workshop series Topics in Translational Neuroscience was initiated with the first theme Psychiatric and Somatic Comorbidity (held on January 18, 2010) and the second with the theme Schizophrenia: from Gene to Behaviour (held on October 29, 2010). Future workshops in this series will be organized twice a year. The annual MHeNS Research Day is another important educational activity for PhD candidates; all can present posters, and a few are selected each year for oral presentations. See for the total overview of the courses, workshops and events annex 1. MHeNS Educational Committee For both generic and specific parts of the PhD program in the School optimal integration requires that the educational leaders of their respective masters and research divisions actively and regularly discuss their educational programs. It is therefore that the MheNS Educational Committee was created in 2009. The four committee members meet once a month and represent the MHeNS PhD program, allied research master tracks, the EURON PhD training and MHeNS three divisions. In 2009-2010, the Educational Platform contributed to the following activities: - participation in meetings and exchange of information on master and PhD programs with other schools and universities within the Dutch Neurofederation and within the network of European Neuroscience Schools - implementation and evaluation of existing MHeNS and EURON PhD courses - expanding the PhD courses program, in particular workshops that bridge the research areas of the three MHeNS divisions (e.g., workshop Human Neuroanatomy and the new workshop series, Trends in Translational Neuroscience, in which PhD students from all three divisions participate two times a year). - inform and advice the board of MHeNS including written reports concerning educational activities. MHeNS PhD coordinator and monitoring of PhD progress and satisfaction The MHeNS PhD coordinator, with support from the MHeNS educational committee as well as the management office and ICT team members, explored a number of options for developing a web-based PhD monitoring system. In addition, an online survey was developed for yearly assessment of progress, career planning, and satisfaction with supervision. All MHeNS promovendi, including those working in affiliated clinical institutions or externally, will be invited to complete this survey in early February each year. Based on these results, new initiatives can be developed to facilitate progress and communication. Responding to a request from the Interfaculty Promovendi Commission, MHeNS also started a pilot project (2010) to assess the needs and satisfaction of the azm promovendi. In addition to these structural activities, the MHeNS PhD coordinator met with individual PhD candidates who were experiencing difficulties and discussed options with them for dealing with these issues (usually problems with supervision). MHeNS PhD representation In 2009, both PhD coordinator and PhD representative visited the three divisions of the school and introduced themselves, elucidated their functions, and explained their position within the school. Further, both PhD coordinator Research Master A-KO Staff members of, in particular, Division 2 participate in 60 the module Psychiatry of the 4-year Research Master Human Neuroanatomy to Psychopathology (Maastricht (NENS). and representative attended the meetings of the IPC (In- 61 terfaculty Promovendi Commission) and reported back to both students and the board of the school. Some of the aims and main tasks concerned making an inventory of the school s educational course offerings, stimulating collaboration between and integration of the three divisions, and improving the school s website in a way that information on everything that might be of interest for former, current or prospective PhD students could be accessed more easily. In addition, PhD students were specifically informed of the possibility of seeking help from the PhD coordinator in dealing with difficulties or confidential issues. After the school was assessed by an external review committee in September 2009, students from each division elected two representatives, who now form the PhD platform of the school. This newly formed platform of PhD representatives is pursuing the goal of stimulating collaboration between divisions, representing PhD interests, and forming the link between PhD students and the board of MHeNS (together with the PhD coordinator). They meet on a regular basis to discuss PhD matters and think of ways to improve or further develop PhD education, for example by implementing new activities such as discussion rounds,

symposia, etc. One of the first steps was planning the first MHeNS MINGLE DAY for PhD students. This day (which took place in March 2010) entailed an informal get-together of PhD students within the school, in order to get to know each other, get to know each other s area of interest, and exchange expertise. 62 annexes

Annex 1 Overview Educational PhD programme 2009-2010 Euron/MHeNS PhD educational program Participants 2009 Courses/workshops/events Location / organizer Description staff MHeNS involved MHeNS Other Euron Total number PhD students PhD students participants Feb 4-6 Course Stereotaxy: from local drug Maastricht / Dr. Y. Temel Stereotaxy is a widely used technique, both clinically and experimentally. Dr. Y. Temel, Prof. Dr. V. Visser-Vandewalle 8 3 22 delivery to deep brain stimulation This course will mainly focus on its experimental applications. In this area of translational neuroscience, however, clinical and experimental developments go hand in hand. The course focusses on basal ganglia physiology, deep brain stimulation and local drug delivery, EEG electrode implantation and recording Feb 9-13 Workshop Drugs and the Brain: an University of Minho (assoc. partner Interactive workshop with discussion groups and debates on the basic Prof. Dr. B. Leonard (Visiting Prof), 3 6 36 64 update in Psychopharmacology of Euron) / Prof. Dr. J. Palha, Prof. Dr. mechanisms of action of psychotropic drugs, clinical psychopharmacology, Dr. J. Prickaerts, Prof. Dr. H. Steinbusch N. Sousa; Maastricht University / how are psychotropic drugs discovered and developed, special topics that 65 Prof. Dr. H. Steinbusch / Prof. Dr. B. link basic and clinical neuroscience Leonard March 17 MHeNS Research Day Maastricht/H. Steinbusch Annual meeting for all members of MHeNS with oral and poster presentations H. Steinbusch, J. van Os, N. Nicolson, 75 none 142 of the research of the three divisions C. van Heugten, P. Martinez March 25 3rd Marie Curie Fellow Meeting Maastricht / H. Steinbusch Annual meeting for all Marie Curie Fellows of FP6 program Euron. Oral H. Steinbusch, M. Losen, P. Martinez, 5 8 30 presentations M. De Baets, J. Prickaerts, Y. Temel March 26 July 7-8 Sept. 26-27 Rodent Neuroanatomy Part I Basic Neuroanatomy: Preparation of the Brain Summer course in Electrophysiology: theory and applications Interactive Symposium about the Novel Object Recognition test Cologne / H. Schröder ULB / S. Schiffmann, D. Gall; Hasselt / J-M Rigo; ULG/ V. Seutin Maastricht / co-organizer J. Prickaerts Course on the anatomy of important brain structures and how the brain is organised. Practical course: focus is on the study of the electrical activity of excitable cells: biophysics, voltage clamp and patch-clamp techniques, cellular imaging The aim of this 2-day interactive symposium is to discuss the various test procedures that are being used and evaluate the possible relevance for the outcome of object recognition studies. For example, which brain structures are involved in this task? Further, we will discuss the use of this test in drug research. Oct 1-2 13th Euron PhD days RU Nijmegen / E. Roubos Annual meeting of all Euron PhD students to present their research orally or via poster. To meet other Euron partner universities and colleague PhD students. Oct 5-7 International course on Stereotaxy, Microsurgery, and Stereology Ondokuz Mayis University, Samsun, Turkey/Prof. Dr. S. Kaplan; Maastricht/ Y. Temel Scientific theory of stereotaxy, and hands-on training in key stereotactic applications. Focus on two main scientific applications: deep brain stimulation and local drug delivery Only Euron partner Cologne staff members is involved 1 8 14 Only Euron partners ULB, Hasselt en ULG 2 2 5 J. Prickaerts 1 1 29 H. Steinbusch, J. Prickaerts 20 37 79 H. Steinbusch, Y. Temel 1 1 30

Euron/MHeNS PhD educational program Participants 2010 Courses/workshops/events Location / organizer Description staff MHeNS involved MHeNS PhD students Other Euron PhD students Total number participants Jan 18 Mhens 1st Translational Workshop Comorbidity Maastricht / N. Nicolson Psychiatric and Somatic comorbidity. Topics: inflammation, HPA, stress, dementia, depression, psycho-somatic disorders, integrated care, vascular pathology, diabetes. Invited experts for presenting key lectures and to be the moderators of discussion. PhD students work in discussion groups on research questions, background papers. N. Nicolson, B. Leonard, J. van Os, D. van den Hove, S. Koehler 21 none 21 Feb 22-25 From human neuroanatomy to psychopathology J. Prickaerts. B. Rutten, P. Aalten Macroanatomy of the Human Brain: dissection; Microscopy brain structures human, mice and rat; lectures on neurodevelopment., cerebrovasculature, aging and pathology, cognition Maastricht The aim is to increase knowledge transfer in the rapidly evolving field of gene-environment interactions in psychiatry, and to forge bridges between J. Prickaerts, B. Rutten, P. Aalten, H. Steinbusch, H. Uylings, K. Schruers, J. van Os, R. van Oostenbrugge 11 2 19 Prof. J. van Os, Dr. B. Rutten, 15 none 28 March Euron Workshop Gene-environment 9-10 interactions in Psychiatry clinical and fundamental science. 66 March 17 MHeNS Research Day Maastricht / H. Steinbusch Annual meeting for all members of MHeNS with oral and poster presentations of the research of the three divisions N. Nicolson, M. van Boxtel H. Steinbusch, I. Myin-Germeys, 68 none 139 67 4 11 30 March 22-26 April 22-23 April 23-24 Sept. -Oct. (8 x 3hr) Workshop Drugs and the Brain: an update in Psychopharmacology Minho (assoc. partner of Euron) J. Palha, N. Sousa; Maastricht / H. Steinbusch Course Experience Sampling Method Maastricht / MHeNS Division Mental Health 2nd Joint Meeting of the Belgian- Dutch Neuromuscular Study Club and the German Reference Center for Neuromuscular Diseases of the DGNN Maastricht / M. De Baets; Aachen / J. Weis The workshop forms a part of a series on brain diseases, biology and psychopharmacology that were held previously in the Netherlands, Germany and Portugal. This year again the University of Minho will be our host! The purpose of the workshop is to give the neuroscientist an understanding of the clinical approaches to psychopharmacology and the clinician an understanding of the neuroscience basis of psychopharmacology. This course gives a full overviw of all aspects related to the use of the Experience Sampling Method in psychopathology: background, techniques, questionnaires, statistics and study implementation. The meeting includes state of the art lectures on motor neuron diseases, polyneuropathies, diseases of the neuromuscular junction and myopathies. Both clinical and basic aspects will be addressed. Course Evidence-Based Psychiatry Maastricht / M/ Drukker This course is designed to provide an update on methodological issues and statistical approaches in psychiatric epidemiology. Topics include research designs, RCTs, confounding & interaction, relative risk, odds ratio, attributive risk, meta-analysis, interpretation of output of regression models with interaction terms (lincom), multilevel analysis, and power. Visiting Prof. B. Leonard, Dr. J. Prickaerts, H,. Steinbusch I. Germeys, Ph. Delespaul, T. Driesen, C. Simons, C. Henquet, D. op t Eijnde, W. Beuken 1 none 12 M. De Baets, M. Losen, P. Martinez 3 3 61 M. Drukker, J. van Os, W. Viechtbauer 8 none 8

Overview Educational PhD programme 2009-2010 Euron/MHeNS PhD educational program Participants 2010 Courses/workshops/events Location/organizer Description staff MHeNS involved MHeNS PhD students Other Euron PhD students Total number participants Oct 29 MheNS 2nd Translational Workshop Schizophrenia Maastricht / N. Nicolson This next MHeNS workshop in the series Topics in Translational Neuroscience will focus on genetic as well as clinical aspects of schizophrenia. Students will work at assignements in discussion groups and will write a critical review N. Nicolson, B. Leonard, J. van Os, D. van den Hove, B. Rutten, G. Kenis, 19 2 23 Nov 10-12 Workshop Update on Alzheimer San Diego, USA This workshop will be organized as pre-meeting for the Society for Neuroscience H. Steinbusch 2 none 33 Research 3rd Edition and is sponsored by ISAO and AHAF. The International Society for Alzheimer Research (ISAO) and American Health Assistance Foundation (AHAF) will organize this 3-day workshop to provide PhD students an overview of the current research developments in experimental and clinical AD 68 presented by experts in the field. 4 none 8 69 Nov 25-26 Course Experience Sampling Method Maastricht / MHeNS Division Mental Health This course gives a full overviw of all aspects related to the use of the Experience Sampling Method in psychopathology: background, techniques, questionnaires, statistics and study implementation. I. Germeys, Ph. Delespaul, T. Driesen, C. SImons, M. Wichers, W. Beuken

Annex 2 Current PhD students (2011) Angela Bouwmans Early detection of Parkinson. Supervisor: Prof.Dr. M. Limburg, Co-supervisor(s): Dr. A. Winogrodzka / Prof.Dr. W. Mess/ Dr. W. Weber Division Cognitive Neuropsychiatry and Clinical Neuroscience Sil Aarts Long-term disease clustering: size and nature of multimorbidity and its reciprocal relation with psychosocial and psychological features in a general practice poplation. Supervisor: Prof.Dr. J. Metsemakers, Co-supervisor(s): Prof.Dr. F. Verhey/ Dr. M. van den Akker / Dr. M.P.J. van Boxtel Hilde Braakman Imaging study in epilepsy: Is there a neuronal correlate for cognitive impairment and response to antiepileptic drugs in children with frontal lob epilepsy? Supervisor: Prof.Dr. B. Aldenkamp, Cosupervisor(s): Prof.Dr. H. Vles / Dr. W. Backes / Dr. P. Hofman Ingrid Brands Psychological adjustment after brain injury. Supervisor: Prof.Dr. D. Wade, Co-supervisor(s): Dr. C. Van Heugten / Dr. S. Stapert Aukje Aben Mind, brain and education: on determinants of effective learning in adolescence Supervisor: Prof.Dr. J. Jolles, Co-supervisor: Dr. R.H.M. de Groot Meindert Buskermolen Behavioural impairments in children with hearing deficits. Supervisor: Prof.Dr. B. Aldenkamp; Co-supervisor: Dr. J. Hoekman Bart Ament Early problem detection and support for frail elderly: evaluation of the effects of an integrated Mickey Chenault Psychometric measures applied to audiological rehabilitation: uncovering factors influencing the chain of care model. Supervisor: Prof. dr. G.I.J.M. Kempen, Co-supervisor(s): Prof.Dr. F. Verhey/ Dr. process. Supervisor: Prof.Dr. B. Kremer P.M.A. van Bilsen / Dr. M. de Vugt 70 Gisela Claessens Coping after brain injury. Supervisor: Prof.Dr. F. Verhey, Co-supervisor(s): Dr. C. Van Heugten / Dr. Monique Anten e/v Wolters Gregorio S. Stapert 71 Laura Baijens Contribution of chlamydia pneumonae infection to atherosclerotic cerebrovasculare disease. Supervisor: Prof.Dr. J. Lodder, Co-supervisor(s): Prof.Dr. C.A. Bruggeman / Dr. A. van de Ven /Dr. M. Voorend Treatment of oropharyngeal dysphagia in patients with Parkinson s disease: Neuromuscular electric stimulation (NMES) versus logopedic dysphagia treatment. Supervisor: Prof.Dr. B. Kremer, Co-supervisor(s): Dr. L. Anteunis / Dr. R. Speyer Lies Clerx Albert Colon Novel diagnostic approaches for the diagnosis of Alzheimer disease: technology assessment and clinical effectiveness. Supervisor: Prof.Dr. F. Verhey, Co-supervisor: Dr. P. Aalten Improved detection of extra-temporal epileptogenic foci using MEG guided advanced MRI-analysis. Supervisor: Prof.Dr. P.A.J.M. Boon, Co-supervisor(s): Dr. P. Hofman / Dr. P. Ossenblok Ellen Barendse Kim Beerhorst Rene Besseling Roberto Binie Neuronal correlates in patients with epilepsy and autism. Supervisor: Prof.Dr. B. Aldenkamp Co-supervisor: Dr. M.P.H.Hendriks Prevalence of low bone mineral density in residents of a long-term facility care centre for people with refractory epilepsy and long-term use of ant-epileptic drugs: a cross-sectional cohort-study. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor: Dr. M. De Krom Impaired Cerebral Connectivity in Chronic Epilepsy. Supervisor: Prof.Dr. B. Aldenkamp, Cosupervisor(s): Dr. W. Backus / Dr. P. Hofman The relationship between stress and epileptic seizures. Supervisor: Prof.Dr. B. Aldenkamp, Cosupervisor(s): Dr. W. Backus / Dr. P. Hofman Brechje Dandachi- Non-motor changes after stimulation of the nucleus subthalamic in patients with advanced Fitzgerald Parkinson disease. Supervisor: Prof.Dr. V. Visser-Vandewalle, Co-supervisor(s): Dr. A. Duits / Dr. A. Winogrodzka Elsbeth de Joode Rosa Drijgers Jan Duijvestijn Technology-supported cognitive rehabilitation: usability and effectiveness of personal digital assistents as external compensation after brain injury. Supervisor: Prof.Dr. F. Verhey, Cosupervisor(s): Dr. C. van Heugten / Dr. M. van Boxtel Apathy in AD and PD. Supervisor: Prof.Dr. F. Verhey, Co-supervisor(s): Dr. P. Aalten / Dr. A. Leentjens Ageing and hearing loss. Supervisor: Prof.Dr. B. Kremer, Co-supervisor: Dr. L. Anteunis Nynke Bodde Prognostic factors for psychogenic pseudoepileptic seizures. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor: Prof. Dr. P.A.J.M. Boon Saskia Ebus Treatment of epileptiform EEG discharges. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor(s): Prof. Dr. P.A.J.M. Boon / Dr. J.B.A.M. Arends

Manon Fens Oliver Gerlach Long-term care after stroke. Supervisor: Prof.Dr. M. Limburg, Co-supervisor(s): Prof.Dr. J. Metsemaekers / Dr. C. Heugten / Dr. G. Beusmans Parkinson Care research. Supervisor: Prof.Dr. M. Limburg, Co-supervisor:Dr. W. Weber Stephan Jansen Maurice Janssen Imaging for the life sciences: medical imaging and movement detection to probe neuroplasticity. Supervisor: Prof.Dr. H. Kingma Quantification and Induction of Neuroplasticity in patients with vestibular disorders. Supervisor: Prof.Dr. H. Kingma, Co-supervisor:Prof.Dr. R. Stokroos Erik Gommer Dynamic cerebral autoregulation: methods and applications. Supervisor: Prof.Dr. W. Mess, Cosupervisor(s): Prof.Dr. R. Panerai / Dr. J Reulen Elissa Klaassen Functional MRI studies into neuro-energetic mechanisms and cognitive effects. Supervisor: Prof. Dr. J. Jolles, Co-supervisor(s): Dr. L. Evers /Dr. R.H.M. de Groot Nienke Gosens Osteoporosis and epilepsy; a study on the effect of antiepileptic drugs on bone metabolism. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor:Dr. M. De Krom Nikki Lee The learning adolescent: Choice processes and motivation. Supervisor: Prof.Dr. J. Jolles, Cosupervisor(s): Dr. R.H.M. de Groot / Dr. L. Krabbendam Nils Guinand Development of a vestibular implant for patients with bilateral vestibular function loss: 1--acute electric stimulation of the vestibular nerve, 2--candidate s quality of life assessment, 3--development of diagnostic and monitoring tools. Supervisor: Prof.Dr. H. Kingma Loes Leenen Anticonvulsants, Epilepsy, Piracetam, Fructose, Infant, Combination Drug Therapy. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor(s): Dr. M. Majoie /Dr. S.M. Evers / Dr. C. Van Heugten Marjolein Legra The role of personality features on behavioral and psychological symptoms of dementia. Supervisor: 72 Prof.Dr. F. Verhey, Co-supervisor:Dr. B. van Alphen Renske Hamel Early detection and diagnosis of Alzheimer s Disease (VSB-MCI study). Supervisor: Prof.Dr. F. Verhey, Co-supervisor:Dr. P. Aalten 73 Jessie Lemmens Implementation an evidenced based protocol for dysphagia screening in stroke patients. Supervisor: Ron Handels Novel diagnostic approaches for the diagnosis of Alzheimer disease: technology assessment and Prof.Dr. R. de Wit, Co-supervisor:Prof.Dr. M. Limburg clinical effectiveness. Supervisor: Prof.Dr. F. Verhey Anouk Linssen Cost effectiveness of screening for hearing lost in adults. Supervisor: Prof.Dr. B. Kremer, Cosupervisor:Dr. Isabelle Hartgerink Lutgens Cognitive functions in patients with allergic rhinitis. Supervisor: Prof.Dr. B. Kremer, Cosupervisor(s): L. Anteunis Dr. E. Vuurman / Dr. A. Vermeeren Willeke Lok PEPPER; Persisting Ear Problems, Providing Evidence for Referrals. Supervisor: Prof.Dr. B. Kremer, Mieke Hermans Cardiomyopathy in myotonic dystrophy type 1; often sene but rarely appreciated. Supervisor: Co-supervisor(s): Dr. L. Anteunis / Dr. C. Meesters Prof.Dr. M. Limburg, Co-supervisor:Dr. C. Faber Arthur Mallinson Visual Vestibular Mismatch: A poorly Understood presentation of balance system disease. Supervisor: Janneke Hoeijmakers Small fiber neuropathy. Supervisor: Prof. dr. R. van Oostenbrugge, Co-supervisor(s): Dr. C. Faber/ Prof.Dr. H. Kingma Dr. I.S. Merkies Esther Martens Ultrasonographic quantification and model evaluation of cerebral blood flow regulation. Supervisor: Janny Hof OAE at compensated middle ear pressure. Supervisor: Prof.Dr. B. Kremer, Co-supervisor(s): Dr. J. Prof.Dr. W. Mess, Co-supervisor(s): Prof.Dr. F. N. van de Vosse / Dr. J. Reulen van Dijk / Dr. L. Anteunis Marjolein Huijts Heidi Jacobs Genetic, molecular and (endothelial) cellular factors in cerebral small vessel disease related cognitive decline. Supervisor: Prof.Dr. J. Lodder, Co-supervisor(s): Dr. R. van Oostenbrugge /Dr. A. Duits Parietal matters in early Alzheimer s Disease: evidence from structural and functional MRI. Supervisor: Prof.Dr. J. Jolles, Co-supervisor(s): Prof.Dr. F. Verhey/ Dr. M.P.J. van Boxtel Veronique Moers-Hornikx Cerebellum, Neuromodulation and Cognition. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Prof. Dr. H. Steinbusch/ Dr. Y. Temel / Dr. G. Hoogland Veronique Moulaert ALASCA = Activity and Life After Survival of a Cardiac Arrest. Supervisor: Prof.Dr. D. Wade, Cosupervisor(s): Dr. J. Verbunt / Dr. C. van Heugten

Anne-Hilde Muris Immune and disease modulating effects of vitamin D in multiple sclerosis. Supervisor: Prof.Dr. R. Hupperts Sylvia Stappenberg- Klinkenberg Treatment of rolandic epilepsy. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor:Prof.Dr. H. Vles Geke Overvliet Ellen Pijpers Imaging bij Rolandische Epilepsie. Supervisor: Prof.Dr. B. Aldenkamp Frailty co-morbiditeit bij oudere mensen. Supervisor: Prof.Dr. A. Nieuwenhuizen Kruseman, Cosupervisor:Prof.Dr. C. Stehouwer Job Postelmans Surgical aspects of cochlear implantation. Supervisor: Prof.Dr. B. Kremer, Co-supervisor:Prof.Dr. R. Stokroos Kim Rijkers Rob Rouhl Stimulating fits. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Prof.Dr. H. Steinbusch/ Dr. M. Majoie Inflamation parameters in cerebral smal vessel diseases. Supervisor: Prof.Dr. J. Lodder, Cosupervisor:Dr. R. van Oostenbrugge Bert ter Mors Acquired Brain injury / neuropsychiatry. Supervisor: Prof.Dr. P. Van Harten, Co-supervisor:Dr. C. Van Heugten Nienke Tielemans Rick van de Langenberg Effectiveness of self-management strategies in CVA patients and their relatives. Supervisor: Prof. Dr. D. Wade, Co-supervisor:Dr. C. Van Heugten Sequential volumetric imaging of cerebellopontine angle tumors. Supervisor: Prof.Dr. B. Kremer, Co-supervisor:Prof.Dr. R. Stokroos Maarten Vaessen Frontal epilepsy in childeren. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor(s): Dr. W. Backes / Dr. P. Hofman Sandra van Abeelen Psychogenic non-epileptic seizures in children. Supervisor: Prof.Dr. B. Aldenkamp 74 Olga Schiepers Nutritional and genetic determinants of cognitive ageing: A neuroepidemiological approach. Supervisor: Wilma van Blarikom Quality of Life following changes in living circumstances of adults with epilepsy and intellectual 75 Prof.Dr. J. Jolles, Co-supervisor(s): Dr. M. van Boxtel /Dr. R.H.M. de Groot disabilities. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor:Dr. A. van Gennep Debby Schrans Duchenne Spierdystrofie. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor(s): Prof.Dr. H. Vles / Dr. J. Hendriksen Frank van Bussel Functional MRI biomarkers of cognitive decrements in diabetes. Supervisor: Prof.Dr. J. Wildberger, Co-supervisor:Dr. J.F.A. Jansen Sanne Smeets Diane Smit Joost Smolders Awareness of deficits after acquired brain injury. Supervisor: Prof.Dr. F. Verhey, Co-supervisor(s): Dr. C. Van Heugten / Dr. R. Ponds Experimental viral labyrinthitis: a neonatal sheep model. Supervisor: Prof.Dr. B. Kremer, Cosupervisor(s): Prof.Dr. R. Stokroos / Prof.Dr. B. Kramer Vitamine D as an immune modulator in multiple sclerosis. Supervisor: Prof.Dr. R. Hupperts, Cosupervisor(s): Prof.Dr. J.Cohentervaert / Dr. J. Damoiseaux Raymond van de Berg Merijn van de Laar Silvie van der Kruijs Vestibular implant. Supervisor: Prof.Dr. H. Kingma, Co-supervisor:Prof.Dr. R. Stokroos Personality factors in psychofysiological insomnia. Supervisor: Prof.Dr. B. Aldenkamp, Cosupervisor(s): Prof.Dr. D.Pevernagie / Dr. I. Verbeek Designing of virual reality tools for cognitive training in children with neurocognitive problems and epilepsy. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor(s): Prof.Dr. H. Vles H. /Dr. J. Hendriksen Lyzel Sonnenschein Mild cognitive impairment (MCI) and early markers of Alzheimer s disease. Supervisor: Prof.Dr. F. e/v Elias Verhey, Co-supervisor:Dr. P.J. Visser Peggy Spauwen Mieke Speth Diabetes and cognition. Supervisor: Prof.Dr. F. Verhey Effect of Botulinum Toxin and rehabilitation in CP on upperlimb function and skills. Supervisor: Prof.Dr. H. Vles, Co-supervisor:prof.dr. Rob J.E.M. Smeets Fleur van Dooren Mitchel van Eeden Jan van Tuijl The role of pyschological variables (depression, anxiety, type D personality) in the pathogenesis of type 2 diabetes and diabetes-related microvascular complications. Supervisor: Prof.Dr. F. Verhey, Co-supervisor(s): Dr. M. Schram / Dr. M.P.J. van Boxtel Psychosocial care after stroke. Supervisor: Dr. C. Van Heugten, Co-supervisor:Dr. S.M.A.A. Evers Post-CVA epilepsy: prevention and treatment. Supervisor: Prof.Dr. J. Lodder, Co-supervisor(s): Prof. Dr. B. Aldenkamp / Dr. J. van Raak

Deliane van Vliet NeedYD-study, Needs in Young onset dementia. Supervisor: Prof.Dr. F. Verhey, Co-supervisor:Dr. M. de Vugt Wilma Boevink What psychiatric patients effectively do to help themselves. Supervisor: Prof.Dr. J. van Os, Cosupervisor(s): v. Tilburg / Dr. B. Kroon / Dr. P. Delespaul Wim van Zwam Els Vanhoutte Neeltje Vermunt Marielle Vlooswijk Alessandro Colasanti Carbon Dioxide as an agent of a primal emotion. Supervisor: Prof. E. Griez Dina Collip Psychotic reactivity to stress: linking phenomenology, biology and genetics. Supervisor: Prof. Dr. I. Myin-Germeys, Co-supervisor:Prof. Jim van Os Klara de Cort Ellen de Loore Interoceptice conditioning. Supervisor: Prof. E. Griez, Co-supervisor:dr. K. Schruers Risk factors for psychosis in adolescents. Supervisor: Prof.Dr. I. Myin-Germeys, Co-supervisor:Prof. Jim van Os Jeroen Decoster Gene-environment interactions in psychosis. Supervisor: Prof.Dr. I. Myin-Germeys, Cosupervisor:Dr. R. van Winkel Stephanie Vos Novel diagnostic approaches for the diagnosis of Alzheimer s Disease: Technology assessment and clinical effectiveness. Supervisor: Prof.Dr. F. Verhey, Co-supervisor:Dr. P.J. Visser Patrick Domen Dysconnectivity in Psychosis: a neuroimaging study. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. 76 77 M. Marcelis Jerome Waterval Hyperostosis cranialis interna. Supervisor: Prof.Dr. B. Kremer Bernice Doove Lonneke Willemstein Anne Zumach Diagnostic procedures in acute SAH. Supervisor: Prof.Dr. J. Wilmink, em, Co-supervisor:Dr. P. Hofman Peripheral Neuropathy Outcome Measures Standardisation Study. Supervisor: Prof.Dr. M. de Baets, Co-supervisor:Dr. C. Faber Organisatie van zorg en medische besluitvorming rondom het levenseinde van dementerende ouderen. Supervisor: Prof.Dr. F. Verhey, Co-supervisor:Prof.Dr. J.M.G.A. Schols Neuronal determinants of cognitive disorders in patients with localization-related epilepsy: a multi-modal MRI study. Supervisor: Prof.Dr. B. Aldenkamp, Co-supervisor:Dr. M. de Krom The influence of the care context on neuropsychiatric symptoms in the demented elderly in nursing homes. Supervisor: Prof.Dr. F. Verhey, Co-supervisor(s): Prof.Dr. J.M.G.A. Schols / Dr. M. de Vugt Language perception and production in impaired children. Supervisor: Prof.Dr. B. Kremer, Cosupervisor(s): Dr. L. Anteunis /Dr. E. Gerrits Preventive child health care in dialogue with data on developmental outcome. Understanding pathways of adaptation: MOMknowsbest. Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Dr. M. Drukker / Prof. F. Ferron Nicole Geschwind Plasticity of reward experience in daily life: the way to prevent depression? Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Dr. M. Wichers / Dr. F. Peeters Martin Gevonden Social exclusion and psychosis: linking minority stress, brain metabolism & mental health. Supervisor: Prof.Dr. I. Myin-Germeys, Co-supervisor(s): dr. J. Selten / Prof. J. Booij Division Mental Health Anton Grech Structural Aetiology of Schizophrenia. Supervisor: Prof.Dr. J. van Os Baer Arts Tim Batink Ibrahim Tolga Binbay Cognitive functioning and bipolar disorder: a prospective, quasi-experimental study. Supervisor: Prof.Dr. J. van Os Experience measuring in Mental Healthcare. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. Marieke Wichers Dissecting the ecogenetic interactions in the urban social environment for psychosis? Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. M. Drukker Giuseppe Guaiana Petra Habets The role of epidemiology as an aid to psychiatric care. Supervisor: Prof. E. Griez Complex Neuro-imaging phenotypes in psychosis. Supervisor: Prof.Dr. J. van Os, Cosupervisor:Marcelis Rob Havermans Stress reactivity to daily events in patients with remitted bipolar disorder. Supervisor: Prof. Dr. M. devries, Co-supervisor:Dr. N. Nicolson

Manuela Heins Dennis Hernaus Nathalie Janssen Stress-reactivity in daily life: prediction of outcome. Supervisor: Prof.Dr. J. van Os, Cosupervisor:Prof.Dr. I. Myin-Germeys Psychotic reactivity to daily life stress: an experimental approach. Supervisor: Prof.Dr. I. Myin- Germeys Childhood Adversity and Salience Dysregulation. Supervisor: Prof.Dr. I. Myin-Germeys, Cosupervisor:dr. J. Schieveld Laura Mandelli Margreet Oorschot Odette Peerbooms Sanne Peeters Genetics in Affective Disorders. Supervisor: Prof. E. Griez Psychological mechanisms underlying paranoia and grandiosity in psychosis. Supervisor: Prof.Dr. I. Myin-Germeys, Co-supervisor:Prof.Dr. J. van Os Epigenetica. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. B. Rutten Brain plasticity in psychosis: a prospective neuroimaging study. Supervisor: Prof.Dr. J. van Os, Cosupervisor:Dr. M. Marcelis Mayke Janssens Predictors of functional outcome in psychosis. Supervisor: Prof.Dr. I. Myin-Germeys, Cosupervisor:Dr. T. Lataster Stefanie Pfeifer At risk for psychosis; exploring cognition as intermediate phenotype. Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Schiller / Krabbendam Nil Kaymaz The Ecogenetics of affective and non affective psychoses. Supervisor: Prof.Dr. J. van Os Judith Rickelt ACID based balance in affective states. Supervisor: Prof. E. Griez Inge Knuts Factors of Nicotine Dependance in Panic Disorder. Supervisor: Prof. E. Griez, Co-supervisor:dr. K. Schruers Sara Schutters Whenn all eyes are on you. Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Dr. K. Schruers / Prof. 78 Westenberg Monique Konings Cannabis en adolescenten. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. C. Henquet 79 Armin Shazad Relation neurocognition and negative symptoms in psychosis. Supervisor: Prof.Dr. I. Myin-Germeys, Ingrid Kramer Daily life emotional dynamics: new source for understanding and treating mental health symptoms. Co-supervisor:Dr. T. Lataster Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. M. Wichers Feikje Smeets ithink: Psychotic disorder: positive, negative and cognitive symptoms in daily life. Supervisor: Rebecca Kuepper Psychosis and the endocannbinooid system: Biological mechanisms of the cannabis psychosis Prof.Dr. J. van Os, Co-supervisor:Dr. T. Lataster relationship. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. C. Henquet Frank van Dael Obsessive compulsive disorder and psychosis. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Prof.Dr. Johan Lataster Psychotic Stress Reactivity in Psychosis Linking Phenomenology, Biology and Genetics. Supervisor: I. Myin-Germeys Prof.Dr. I. Myin-Germeys, Co-supervisor:Prof.Dr. J. van Os Margriet van der Werf Risk for Psychosis: a Life Span Perspective. Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Prof.Dr. Carsten Leue Studies at the interface of psychosomatic medicine costs and trends, from clinic to primary care. F. Verhey/Dr. R. van Winkel Supervisor: Prof.Dr. J. van Os Martine van Nierop Social stress and psychose. Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Prof.Dr. I. Myin-Germeys Ritsaert Lieverse Chronobiopsychosocial perspectives of old age major depression. A randomized placebo-controlled /Dr. R. van Winkel trial with bright light. Supervisor: Prof.Dr. J. van Os Mark van Winkel Active mobilisation of psychological resources and work engagement during burn out treatment. Claudia Lothmann Reward experience in daily life: from fundamentals to clinical practice. Supervisor: Prof.Dr. J. van Supervisor: Prof.Dr. I. Myin-Germeys, Co-supervisor(s): Dr. M. Wichers / Dr. F. Peeters Os, Co-supervisor:Dr. M. Wichers Catherine van Zelst Destigmatizing mental illness. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. Ph. Delespaul Shahed Mafi Rad GxE and epigenetic regulation in psychosis. Supervisor: Prof.Dr. J. van Os, Co-supervisor(s): Dr. B. Rutten / Dr. G. Kenis Mirjam Wouda Childhood Adversity and Salience Dysregulation. Supervisor: Prof.Dr. J. van Os, Co-supervisor:Dr. J. Schieveld

Division Neuroscience Linda Ackermans Deep brain stimulation of the thalamus in intractable Tourette patients. Supervisor: Prof. Dr. E. Beuls, Co-supervisor(s): Prof.dr. V. Visser-Vandewalle / Dr. A. Duits / Dr. D. Cath Pablo Andrade - Montemayor Mayienne Bakkers Bart Biallosterski Pinching questions on pain. Supervisor: Prof.Dr. H. Steinbusch Small fibre neuropathy in sarcoidosis. Diagnosis, athogenesis and implications for treatment. Supervisor: Prof.Dr. M. de Baets, Co-supervisor(s): Prof. Dr. M. Drent / Dr. C. Faber / Dr. I. Merkies Afferent recording and non voiding activity in the motor sensory system of the bladder. Supervisor: Prof.Dr. Ph. van Kerrebroeck, Co-supervisor(s): Dr. G. van Koeveringe / Dr. S. de Wachter Kimberly Cox Fetal asphyctic preconditioning: The impact on brain morphology and gene expression. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Prof.Dr. L. Zimmermann / Dr. D. Gavilanes Boris Cox Multimodal Concept after Liver Surgery. Supervisor: Prof.Dr. M. Marcus, Co-supervisor:Prof. Dr. C. de Jong Rogier de Jong Niels de Vries Jochen De Vry Frank Dennissen Muriel Doors Marie Elshout Paul Ernest Markus Gantert Modulation and adaption in the normal and obstructed urinary bladder: a morphological and functional assessment. Supervisor: Prof.Dr. Ph. van Kerrebroeck Comparison of Functional and Visual Outcomes after ReSTOR, Array and a Monofocal Intraocular Lens Implantation. Supervisor: Prof.Dr. F. Hendrikse, Co-supervisor:Dr. R.M.M.A. Nuits Role of brain-derived neurotrophic factor (BDNF) in neuronal and synaptic plasticity in affective disorder. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Prof.Dr. M. de Baets / Dr. J. Prickaerts / Dr. P. Martinez-Martinez Gerard Bode Crossing the blood-brain barrier and finding novel players in neurodegenerative protein aggregation. Supervisor: Prof.Dr. M. de Baets, Co-supervisor(s): Prof.Dr. H. Steinbusch/Dr. P. Martinez- 80 Martinez Stefan de Wachter Urinary Bladder, Urodynamics, Sensation, Urination, Stress Urinary Incontinence. Supervisor: Prof.Dr. Ph. van Kerrebroeck 81 Eva Bollen Glutamatergic signal transduction in hippocampal memory processes. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Dr. J. Prickaerts Fabien Boulle Epigenetic modulation of bdnf gene: implications in adult pathology. Supervisor: Prof.Dr. H. Steinbusch Esther Bouman Ellen Brunenberg Yanny Cheng Quality Standards in Aneasthesiological Medical Systems. Supervisor: Prof.Dr. M. van Kleef, Cosupervisor(s): Prof.Dr. M. Marcus / Dr. H.F. Gramke Visualisation of the direct afferents from motor cortex to the subthalamic nucleus as a means of defining the motor part of the subthalamic nucleus. Supervisor: Prof.Dr. B. Ter Haar Romeny, Co-supervisor(s): Prof.dr. V. Visser-Vandewalle / Dr. B. Platel Keratoplasty. Supervisor: Prof.Dr. F. Hendrikse, Co-supervisor:Dr. R.M.M.A. Nuits Postnatal dysfunction of the major cellular clearing systems in Alzheimer s disease. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Dr. F. van Leeuwen Clinical applications of optical coherence tomography in anterior segment surgery. Supervisor: Prof.Dr. F. Hendrikse, Co-supervisor:Dr. R.M.M.A. Nuits Outcome studies and monitoring of patients in ophthalmology. Supervisor: Prof.Dr. F. Hendrikse Progression from glaucoma. Supervisor: Prof.Dr. F. Hendrikse Chorioamnionitis as a multi-organ disease of the fetus. Supervisor: Prof.Dr. L. Zimmermann, Cosupervisor(s): Prof. Dr. B. Kramer / Dr. D. Gavilanes Leonidas Chouliaras Epigenetics of Stress from Affective Psychopathology to Alzheimer s Disease. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Prof.Dr. J. van Os / Dr. B. Rutten / Dr. D. v.d. Hove Romina Gentier Studying the anatomy of Aß and a-synuclein aggregation in Alzheimer s disease and Parkinson s disease in an environment of proteasomal stress. Supervisor: Prof.Dr. H. Steinbusch Joris Coonen Erwin Cornips Fetal Nociception and Pain. Supervisor: Prof.Dr. M. Marcus, Co-supervisor:Dr. B. Joosten Clinical aspects of thoracic disc herniations. Supervisor: Prof.Dr. K. van Overbeeke Fleur Goezinne Clinical implications of retinal detachment. Supervisor: Prof.Dr. F. Hendrikse, Co-supervisor(s): Prof Dr. A. Kijlstra / Prof. Dr. E.C. La Heij

Alejandro Gomez Analysis of repair mechanisms at the Neuromuscular junction. Supervisor: Prof.Dr. M. de Baets, Co-supervisor(s): Dr. P. Martinez- Martinez / Dr. M. Losen Ralph Maassen The development and clinical implementation of a manual emergency ventilator. Supervisor: Prof.Dr. M. Marcus, Co-supervisor:Prof. A. van Zundert Caroline Hammels A novel anti-inflammatory IgG immunotherapy in Alzheimer s disease. Supervisor: Prof.Dr. M. de Baets Tom Marcelissen Experimental Aspects of Sacral Neuromodulation. Supervisor: Prof.Dr. Ph. van Kerrebroeck, Cosupervisor:Dr. S. de Wachter Rhea Heeringa (Sub) cortical integration of urge sensation. Supervisor: Prof.Dr. Ph. van Kerrebroeck, Cosupervisor:Dr. G. van Koeveringen Marisela Martinez - Claros Role of brain derived neurotrophic factor (BDNF) in hippocampal plasticity in relation to stresscognition interaction. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Dr. J. Prickaerts Sarah Hescham Deep brain stimulation in experimental Alzheimer s disease. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Prof.Dr. K. van Overbeeke / Dr. Y. Temel Chiara Mencarelli The role of cert in neurodegenerative diseases AD, PD. Supervisor: Prof.Dr. H. Steinbusch, Cosupervisor(s): Prof.Dr. M. de Baets / Dr. P. Martinez-Martinez Ali Jahanshahianvar The role of the dorsal raphe nucleus in neurodegeneration and neuroregeneration. Supervisor: Annelien Mertens Endothelial progenitor cells in Alzheimer s disease. Supervisor: Prof.Dr. J.W. Cohen Tervaert, Cosupervisor(s): Prof.Dr. H. Steinbusch, Co-supervisor:Dr. Y. Temel Prof. Dr. J. Lodder / Dr. R. van Oostenbrugge / Dr. J.G.M.C. Damoiseaux / Drs. E. Pijpers / Dr. M.M.G.L. Thewissen Mark Janssen SelectStim: towards a selective stimulation of the motor part of the subthalamic nucleus. Supervisor: 82 Prof.Dr. V. Visser-Vandewalle, Co-supervisor:Dr. Y. Temel Jose Luis Nava Investigation of a human stem cell based intervention strategy in an experimental model of amyotrophic lateral sclerosis. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Prof. Dr. J. Weis 83 Reint Jellema Preterm babies with neurological damage as patients for stem cell therapy. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Prof. Dr. B. Kramer / Dr. D. Gavilanes Leo Noordzij Anatomisch en functioneel herstel na ablatio chirurgie. Supervisor: Prof.Dr. F. Hendrikse Liesbeth Knaepen Long-term impact of repetitive neonatal pain exposure on the developing pain network. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor(s): Prof. Dr. D. Tibboel / Dr. B. Joosten / Dr. J. Patijn Dennis Oerlemans Further progress in Sacral Nerve Stimulation for neuromodulation of the lower urinary tract. Supervisor: Prof.Dr. Ph. van Kerrebroeck, Co-supervisor(s): Prof. dr. R. de Bie / Dr. E.H.J. Weil Stephanie Knippenberg Combination therapy in multiple sclerosis. Supervisor: Prof.Dr. R. Hupperts, Co-supervisor(s): Prof. Dr. J. Cohen Tervaert / Dr. M. Thewissen / Dr. J. Damoisieaux Evelyn Peelen Neurological and immunological aspects of vitamin D in MS patients. Supervisor: Prof.Dr. R. Prof. Dr. R. Hupperts, Co-supervisor(s): Prof. Dr. J. Cohen Tervaert Albère Koke Tens basic and clinical effects. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor(s): Prof. Dr. R. Smeets / Dr. J. Patijn Wouter Pluijms The Mechanism of Spinal Cord Stimulation Treatment in Diabetic Polyneuropathy. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor(s): Dr. C. Faber / Dr. B. Joosten Elke Kuypers Developmental changes after chorioamnionitis and antenatal steroids. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Prof. Dr. B. Kramer Elien Pragt Ontwikkeling neuropathisch pijnmodel. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor:Dr. B. Joosten Marijke Lemmens Cell Focus on ad - Morphological alterations in mouse models of Alzheimer s disease. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Prof. Dr. C. Schmitz Sajjad Rahnama i Alternative views on pathophysiology of the overactive bladder syndrome and related treatmentstrategies. Supervisor: Prof.Dr. Ph. van Kerrebroeck Randall Leong Optimalization of Sacral Neuromodulation Therapy. Supervisor: Prof.Dr. Ph. van Kerrebroeck, Cosupervisor(s): Prof. dr. R. de Bie / Dr. S. de Wachter Ine Rayen Neuroplasticity and neuromodulation of behaviour in offspring exposed to maternal depression and SSRI medications: involvement of the HPA axis and the 5-HT system. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Dr. J. Pawluski / Prof. Jacques Balthazart / Dr. Thierry Charlier

Olga Reneerkens The role of PDE2 and PDE10 inhibitors in cognitive processes. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor:Dr. J. Prickaerts Michiel Truin The Mechanism of Spinal Cord Stimulation Treatment of Experimental Neuropathic Pain. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor:Dr. B. Joosten Lucas Ricker Francesco Risso Andrea Sannia Biochemical and clinical factors in rhegmatogenous retinal detachment and proliferative vitreoretinopathy. Supervisor: Prof.Dr. F. Hendrikse, Co-supervisor(s): Prof Dr. A. Kijlstra / Prof. Dr. E.C. La Heij Clinical and experimental markers of perinatal asphyxia in different biological fluids. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Dr. D. Gavilanes / MD, PhD Diego Gazzolo, Clinical and experimental markers of perinatal asphyxia in different biological fluids. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Dr. D. Gavilanes / MD, PhD Diego Gazzolo, Suze Valen Koen van Boxem Franciscus van der Meer Diabetic macular oedema. Supervisor: Prof.Dr. F. Hendrikse Effects of pulsed radiofrequency of the dorsal root ganglia in sciatica. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor(s): Prof. A. van Zundert / Dr. B. Joosten Methods for development of optimal sampling strategies for therapeutic drug monitoring and population pharmacokinetics using Maximum A Posteriori Bayesian estimation. Supervisor: Prof.Dr. L. Zimmermann, Co-supervisor:Prof.Dr. M. Marcus Margriet van der Reis Outcome and quality of life of patients with exudative macular degeneration. Supervisor: Prof. Olaf Schijns Visualisation of the Gaba-transporter in temporal lobe epilepsie. Supervisor: Prof.Dr. K. van Overbeeke, Dr. F. Hendrikse Co-supervisor:Dr. G. Hoogland Maarten van Eerd Radiofrequenxy Treatment in Cervical Facet Joint Pain. Supervisor: Prof.Dr. M. van Kleef, Cosupervisor(s): 84 Dr. J. Patijn / Prof. A. van Zundert Matthias Seehase Chorioamnionitis as a multi-organ disease of the fetus. Supervisor: Prof.Dr. H. Steinbusch, Cosupervisor:Prof. Dr. B. Kramer 85 Frank van Eijs Effects of early spinal cord stimulation in CRPS-1. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor(s): Annerieke Sierksma Depression as a risk factor for Alzheimer s disease. Supervisor: Prof.Dr. H. Steinbusch, Cosupervisor(s): Dr. C. Faber / Prof. A. van Zundert Dr. J. Prickaerts / Dr. D.v.d. Hove Aukje van Gestel Cost-effectiveness of different strategies for the treatment and monitoring of ocular hypertension Rachel Slangen Effect of spinalcord stimulation in painful diabetic neuropathy. Supervisor: Prof.Dr. M. van Kleef and glaucoma. Supervisor: Prof.Dr. F. Hendrikse Martijn Smits Helga Smits Michelle Sparnaaij Sonny Tan Sacral neuromodulation: new developments. Supervisor: Prof.Dr. Ph. van Kerrebroeck Spinal Cord Stimulation and Experimental CRPS in the rat. Supervisor: Prof.Dr. M. van Kleef, Cosupervisor:Dr. B. Joosten The placental impact on perinatal asphyxia and fetal asphyctic preconditioning. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Dr. D. Gavilanes / Dr. E. Strackx The subthalamic nucleus and midbrain serotonergic neurones: a novel motor limbic interface. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Prof.dr. V. Visser-Vandewalle / Dr. Y. Temel Bart van Gorp Toll-like receptors and central neuropathic pain. Supervisor: Prof.Dr. M. van Kleef, Co-supervisor(s): Prof.Dr. M. de Baets / Dr. R. Deumens Sabien van Neerven Modulation of the neuroinflammatory response after spinal cord injury. Supervisor: Prof.Dr. H. Steinbusch, Co-supervisor(s): Prof.Dr. M. van Kleef / Dr. R. Deumens / Prof. Dr. J. Mey Sonja van Nes Anco van Vostkuilen Peripheral Neuropathy Outcome Measures Standardisation (Perinoms) Study. Part 1. Supervisor: Prof. Dr. P. van Doorn, Co-supervisor(s): Dr. C. Faber / Dr. I.S. Merkies Results and Improvements in Sacral Neuromodulation. Supervisor: Prof.Dr. Ph. van Kerrebroeck Annelien Tan The quality of glaucoma surgery. Supervisor: Prof.Dr. F. Hendrikse Maurice Theunissen Prevalence and predictors of chronic postsurgical pain after hysterectomy. Supervisor: Prof. Dr. M. L. Peters, Co-supervisor(s): Prof. Dr. M. Marcus / Dr. H.F. Gramke Nicole Veldhorst Delivery Systems in Anesthesiology. Supervisor: Prof.Dr. M. Marcus, Co-supervisor(s): Prof. K. Neef / Dr. P.H. van der Kuy Vera Vennemann Nonvoiding activity. Supervisor: Prof.Dr. Ph. van Kerrebroeck

Nienke Visser Rinske Vlamings Evi Vlassaks Toric intracoular lenses in correcting astigmatism. Supervisor: Prof.Dr. F. Hendrikse, Cosupervisor:Dr. R.M.M.A. Nuits Deep brain stimulation in Huntington s disease. Supervisor: Prof.Dr. H. Steinbusch, Cosupervisor(s): Prof.dr. V. Visser-Vandewalle / Dr. Y. Temel Fetal asphyctic preconditioning: The impact on the inflammatory response and on the development of the neuro-immune system. Supervisor: Prof.Dr. H. Vles, Co-supervisor(s): Prof.Dr. M. de Baets / Dr. D. Gavilanes / Prof. Dr. B. Kramer Kathleen Vrolix EU/Myastaid/LSHM-CT-2006-project. Supervisor: Prof.Dr. M. de Baets, Co-supervisor(s): Dr. M. Martinez-Martinez / Dr. M. Losen 86

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