2014 Vol. 26No. 167 45 RS 45 30 RS RSV RSV 1978 T cytotoxic T lymphocyte CTL MHCHLA ZinkernagelDoherty 1 CTL MHC CTL 23 1 2 HLA B52 B7 2 3 CTL T cell receptortcr HLAclass 3 CTL HLA B52B7 TCR CTL clonal expansion CTL CTL clone B52B7 B52B7 2 1984 1 1986 4 NY Ogra 0608543 1 16
68 2014 CTL 1 CTL 23 RSV 20 3 RSV RSV 1 RSV RSV A B AB 2 CTL HLA HLA B52B7
2014 Vol. 26No. 169 3 RSV HEp2 4 46 PCR RSV G RSV 10 23 79 G 60 B 2 12 10 4RSV AB 19801996 23
70 2014 5RSV RSV IgAIgG IgA IgG 2 IgA 0.1 mgml RSV 1 RSV RSV RSV RSV RSV nasopharyngeal secretionnps IgA IgG IgG 12 5 RSV 6 11 2 RSV RSV 7 RSV 2 12 RSV IL6TNF 8 13 in vitro RSV
2014 Vol. 26No. 171 6RSV RSV IgAIgG RSV IgAIgG IgA 0.1 mgml mrna 2 10 14,15 in vitro RSV NO 16,17 9 RSV RSV TLR3 TLR4 2 RNARSV F LPS HDM house dust miteil 8 RANTES l l 7RSV 2 HE 8RSV IL6 TNF IL6TNF IgA 0.1 mgml 1821 LT
72 2014 9RSV 10RSV 10RSV RSV TLR4 SNPs 22 23 RSV 3 RS RSV 11 RSV 2 in vivo in vitro RSV htert in vivo
2014 Vol. 26No. 173 11 RSV RSV RSV 24 RSV RSV RSV occludinclaudin 4 RSV RSV TGFPKCHIF1NF B 12 24,25 26,27 RS RSV reactive airway diseaserad NTT 20032010 RSV 1 1 RSV RSV 28 RSV MMPmatrix metalloproteinase MMP10 29 MMP10 RSV RAD RS 20 RSV 2
74 2014 12RSV RSV TGFPKCHIF1NFB RSV RSV RSV 1990. 1 RSV 2001. 7 RSV 2004.11 RSV 2011.11 RSV RSV 2003.11 RSV 5 1998. 6 RSVF MAbFDA 2002. 1 CLD 2005.10 CHD 2013. 8 RSV RSV ELISA RSV 1990 5 13 3032 RSV MedImmune 1998 RSV complementarity determining regioncdr IgG RSV AB RSV RSV
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