DIMITRIOS NIKOLAOU MD MRCOG Consultant Obstetrician-Gynaecologist Sub-specialist in Reproductive Medicine and Surgery



Similar documents
CONSENT TO PARTICIPATE IN THE IN VITRO FERTILIZATION-EMBRYO TRANSFER PROGRAM

In Vitro Fertilization

Fertility care for women diagnosed with cancer

London Fertility Centre Price List

FINANCIAL INFORMATION FOR PATIENTS

Who is this leaflet about and who is it for? Why would I need to receive donated eggs?

IN VITRO FERTILISATION IVF and ICSI

WOMENCARE A Healthy Woman is a Powerful Woman (407) Birth Control Pills

Information for you Abortion care

abortion abortion abortion abortion abortion abortion abortion on abortio abortion ortion abortion abortion abortion abortion abortio

progestog progestogen stogen-only pill progestogen progestogen-only pill he progestogen-only pill progestogen-onl progestogen-o the progestogenonly

Abnormal Uterine Bleeding

TERMINATION OF PREGNANCY- MEDICAL

In - Vitro Fertilization Handbook

EARLY PREGNANCY LOSS A Patient Guide to Treatment

Consent for In Vitro Fertilization

IVF & FET SURROGAC Y PROCEDURES EXPLANATION OF FEES

Information on termination of pregnancy (abortion) A series of information leaflets on termination of pregnancy services in Greater Glasgow & Clyde

Birth Control Options

Artificial insemination with donor sperm

injections injections injections injections injections injection injections injections injections tions njections injections injections injections

Assisted Reproductive Technologies at IGO

Gynaecology Service. Saint Mary s Hospital. The Whitworth Clinic. Information for patients

the IUD the IUD the IUD the IUD the IUD the IUD the IUD the IUD the IUD the IUD the IUD the IUD the IUD your guide to

Center for Women s Reproductive Care at Columbia University

This is Jaydess. Patient Information. What is Jaydess? How does Jaydess work?

Clinical Policy Committee

Our laboratory guide for you and your embryos

implant contraceptiv contraceptive contraceptive raceptiv contraceptive implant contraceptive contraceptive ontraceptive implant ontraceptive im

IUD. the IUD. the IUD. the IUD. the IUD. the IUD. the IUD. the IUD. the IUD. the IUD. your guide to

Egg Sharing Price list

Information Leaflet about IVF and ICSI

IVF OVERVIEW. Tracy Telles, M.D.

Diary Card. Cerazette. Keeping a record. For women prescribed Cerazette. How do I find out more?

How to choose an IVF clinic and understand success rates: Questions to ask when choosing an IVF clinic.

THE CENTER FOR ADVANCED REPRODUCTIVE SERVICES (CARS) (The Center) CONSENT FOR IN VITRO FERTILIZATION AND EMBRYO TRANSFER

IUD. the IUD. the IUD. the IUD. the IUD. the IUD. the IUD the IUD. the IUD. the the IUD. the IUD. the IUD. the IUD. the IUD. the IUD.

In Vitro Fertilization (IVF) Page 1 of 11

WOMENCARE A Healthy Woman is a Powerful Woman (407) Menstruation

Polycystic Ovarian Syndrome

טופס הסכמה לטיפולי הפרייה חוץ גופית

Centre for Preimplantation Genetic Diagnosis. Genetic testing. Care. Excellence. Support. Advice PGD

Information for Egg Donors for Research

NON MEDICARE FEES CANBERRA FERTILITY CENTRE VERSION JANUARY 2015 AM QWB 295

Homerton Fertility Centre, London

Sterilisation for women and men: what you need to know

Patient information. Goserelin Zoladex Breast Services Directorate PIF 1005 V3

Understanding Endometriosis - Information Pack

Risks and complications of assisted conception

ency emergency contra-

Guide to IVF Laboratory Results

Acute pelvic inflammatory disease: tests and treatment

Copper intra-uterine device (IUD)

Introduction Ovarian cysts are a very common female condition. An ovarian cyst is a fluid-filled sac on an ovary in the female reproductive system.

ivf Step-by-step through IVF Optimising success Risks and side effects Decisions to be made Managing your cycle

INFORMED CONSENT FOR EGG DONORS PRACTITIONER S GUIDE TO USING THE MODEL FORM

What is the menopause and what are the symptoms?

How do fertility drugs work?

Consent for Frozen Donor Oocyte In Vitro Fertilization and Embryo Transfer (Recipient)

REPRODUCTIVE MEDICINE AND INFERTILITY ASSOCIATES Woodbury Medical Arts Building 2101 Woodwinds Drive Woodbury, MN (651)

SO, WHAT IS A POOR RESPONDER?

Timing is everything. Ovulation Tracking. Patient Information Booklet

WOMENCARE A Healthy Woman is a Powerful Woman (407) Endometriosis

Fertility-related choices. A decision aid for younger women with early breast cancer

Midland Fertility Services Blastocyst Transfer

Reproductive Technology. Chapter 21

U.K. Familial Ovarian Cancer Screening Study (UK FOCSS) Phase 2 Patient Information Sheet

Egg Donation Patient Information Becoming or using an egg donor

abortion your questions answered

ABORTION WHAT YOU NEED TO KNOW

Getting Pregnant: The Natural Approach Revealing the Secrets to Increase Your Fertility

FAQ CLINIC AND DOCTORS. What is the name and address of your clinic?

swine flu vaccination:

Pre-implantation Genetic Diagnosis (PGD)

what is an abortion where can I go for help? SAMPLE do my parents have to know?

Patient information leaflet for Termination of Pregnancy (TOP) / Abortion

University Hospitals Coventry and Warwickshire NHS Trust. Centre for Reproductive Medicine. We Care. We Achieve. We Innovate.

Information on. Abortion Services. Telephone

Vaginal hysterectomy and vaginal repair

Script/Notes for PowerPoint Presentation. Medication Use Safety Training for Seniors (MUST for Seniors)

Gonorrhoea. Looking after your sexual health

Ovarian cancer. Patient information from the BMJ Group. What is ovarian cancer? What are the symptoms?

Female Reproductive System. Unit 8 Lesson 2 Continued

So you think you might be pregnant?

Patient identifier/label: Page 1 of 6 PATIENT AGREEMENT TO SYSTEMIC THERAPY: CONSENT FORM FEC-T. Patient s first names. Date of birth.

Effective long-lasting strategy to prevent unintended pregnancy. The intrauterine system for contraception after abortion.

OVARIAN CYSTS. Types of Ovarian Cysts There are many types of ovarian cysts and these can be categorized into functional and nonfunctional

Mindfulness-based stress reduction (MBSR)

Understanding Fertility

Frozen Donor Embryo Transfer Price List, EDI 2016

The Menopause and Subtotal Hysterectomy

All methods of birth control are MUCH SAFER than being pregnant! If 100 women use each method for a year, how many of them get pregnant?

Lesbian Pregnancy: Donor Insemination

Support information for women, their partners and families. Early Pregnancy Loss (Miscarriage)

Abortion. just so you know

FDA-Approved Patient Labeling IMPLANON (etonogestrel implant) Subdermal Use

Department of Gynaecology Early medically induced termination of pregnancy. Information for patients

Tower Hamlets CCG Fertility policy

So you think you might be pregnant?

NHS cervical screening Helping you decide

Transcription:

DIMITRIOS NIKOLAOU MD MRCOG Consultant Obstetrician-Gynaecologist Sub-specialist in Reproductive Medicine and Surgery Private secretary: Tel: 07515 161 203 www.fertilityforlife.com secretary@fertilityforlife.com IVF on a Cetrotide protocol with Mr Nikolaou at Chelsea Westminster Here is what you need to do if you have been told that you are on a Cetrotide protocol for having treatment with Mr Nikolaou at Chelsea Westminster: 1) REGISTER WITH ACU First you need to register with the Assisted Conception Unit (ACU). Go to our website www.fertilityforlife.com, in the Chelsea/Westminster page, and it is one of the downloadable documents on your left hand side. You need to e-mail this form to the Assisted Conception unit (ACU) to the private patient coordinator, Ksenya, at Ksenya.Kirnitski@chelwest.nhs.uk, and copy at acu@chelwest.nhs.uk Alternatively, you can give the form in person to the receptionist at the ACU. 2) BOOK AN APPOINTMENT WITH THE NURSE Once you have registered, with the ACU, call ACU reception on 020 3315 8585 and ask to make an appointment to see a nurse for a nurse consultation. You need to mention that you are having private treatment with Mr. Nikolaou/Fertility for life. Both you and your partner will need to attend this meeting. You should not start treatment before seeing the nurse as there are important issues to be sorted out first. If there are any problems booking a nurse meeting, you should call the ACU on 0208 746 8585 and ask to speak to Ksenya, the private patient coordinator, or e mail her at Ksenya.Kirnitski@chelwest.hs.uk. 3) The treatment will start with your first period AFTER seeing the nurse. When your period comes, call the ACU reception on 020 8 746 8585 to book a treatment scan for day 2 or 3. The scans are done by the sonographer in the morning, 830-1230am in the ACU. After your scan you always see a nurse. This is the time to ask any questions that you may have about your ongoing treatment. If you have wider issues to discuss, you need to call my secretary and book a consultation. This will be charged at a normal rate as a follow up consultation. 4) If I have given you the oral contraceptive pill microgynon to take before you start your IVF treatment, you need to take it from the beginning of your menstrual cycle the month before the IVF treatment and take it for 21 days. Book your first treatment scan 3-5 days after stopping the microgynon, irrespective of bleeding. Occasionally I will give you 2 packs of microgynon. In this case you need to take the 21 active tablets of the first pack and then move on to the second pack without break, and stop when I tell you. The first scan will be 4-6 days after stopping microgynon. Not everyone has to take the contraceptive pill.

5) The purpose of the first scan is to ensure that all is OK to start ovarian stimulation. If there is a problem, such as a big ovarian cyst or an endometrial polyp, we may need to postpone the treatment for another cycle. 6) Assuming all is OK, we will start ovarian stimulation after the first scan, at a dose that will be individual to you. 7) Each time that you have a scan and a blood test, during your IVF cycle, the nurse will show the results to my consultant colleague or me in the afternoon. We will see the chart with the growing eggs and blood levels and decide if we need to change the dose of your medication. The nurses will call you in the afternoon to give you instructions. 8) You will need to have a second scan, and blood test, usually around 5 days after starting ovarian stimulation. At that stage we will assess the ovarian response and may adjust the dose of the medication. We will also start a second daily injection, which is called Cetrotide. The purpose of the first injection (Gonal F or Menopur) is to make the eggs grow. The purpose of the second injection (Cetrotide) is to make sure you will not ovulate until we collect your eggs. 9) You carry on doing both injections daily and we arrange for you to have 1 or 2 more scans and blood tests to monitor the ovarian response. Usually after 10-12 days of injections you are ready for egg collection. 10) There is an injection that is called Ovitrelle, which triggers the final maturation of the eggs prior to egg collection. The ACU nurse will call you to give you an exact time for having this injection, which will be usually between 8-11pm. Usually 37 hours later we do the egg collection. If we wait much longer you will ovulate. Sometimes we use a different drug instead of Ovitrelle. 11) You will not have any more injections after taking Ovitrelle. The day of egg collection you need to come to the ACU, fasted for 6 hours (no food or drink). Your partner needs to come with you to provide a sperm sample (unless we are using frozen or donor sperm). He needs to abstain from ejaculation for 3-5 days. The nurse will tell you exactly what time to come to the ACU. 12) The egg collection will be done under sedation, which will be administered by a nurse. You will be drowsy but not necessarily asleep. Your partner or a friend will need to take you home. 13) The egg collection will last for 15 min on average. You will go home a couple of hours later. The nurse will give you instructions what to do after an egg collection. The same night you will start using progesterone supplements, usually cyclogest pessaries. You will have one pessary rectally the same day as the egg collection and two a day rectally from the following day. You will be able to use them vaginally after the embryo transfer. 14) The next day you will be contacted by the embryologist by mid-day, to find out if any eggs have fertilized and how many embryos you have. The embryologist will tell you when to come for embryo transfer. This may be revised depending on the number and quality of your embryos.

15) You will carry one using progesterone supplements until the pregnancy test. Usually we recommend a urinary pregnancy test 2 weeks after the embryo transfer. Sometimes we also recommend intramuscular injections of progesterone and other medication in addition to the vaginal pessaries. 16) If the pregnancy test is positive you will need to carry on using vaginal progesterone pessaries and book a pregnancy assessment scan by contacting the receptionist at the ACU on 0208 7468585. This will be 3 weeks after the positive pregnancy test. If the pregnancy test is negative you will stop all medication and wait for a period. Sometimes the bleeding starts before the pregnancy test. If it is only slight bleeding, you carry on with your medication. If it is a heavy period then you stop.

General information about private IVF with Fertility for life/mr. Nikolaou at Chelsea Westminster Location: We will do your treatment at the Assisted Conception Unit, Chelsea and Westminster. This is on the 4 th floor, Lift bank D. The nearest underground tube stations are: Earl s Court and South Kensington. Website: www.chelwest.nhs.uk/acu E mail: acu@chelwest.nhs.uk (ACU reception) Tel: 020 3315 8585 Fax: 020 3315 8921 Emergency nurse phone number for out of hours: 07768 988 182 (only use in a real emergency). Alternatively you can call the switchboard of Chelsea Westminster on 020 8 746 8000 and ask the receptionist to call the ACU emergency line. Side-effects of drugs Prostap and buserelin can cause menopausal symptoms, such as tiredness, headaches, night sweats, hot flushes, nausea, mood changes. Gonal-F or Menopur can cause headaches, breast tenderness, nausea and tiredness. When you are near the egg collection you may feel heaviness or pulling inside your abdomen as your ovaries will be heavier. The cyclogest pessaries and Crinone cream can cause bloatedness and constipation. With crinone you can experience lumps of brown-stained gell coming out of the vagina. Don t panic, this is just the gel that carries the drug and the brown is almost certainly old blood from the site of the egg-collection. Cetrotide can cause local skin irritation which normally subsides after a few days.

Risks IVF is not without risks. We normally discuss them in the planning appointment and I am always happy to provide more clarifications during the treatment. Particularly you should be aware of the following: 1) The risk of poor-ovarian response and cycle cancellation. Note: If a cycle in cancelled before eggcollection, a cancellation fee is charged to cover the cost of work carried out up to that point. This is included in the price-list. 2) The risk of over-response and ovarian hyperstimulation syndrome. We take steps to minimize this risk, which is below 3%, including prevention and management. However, if you develop clinical ovarian hyperstimulation you will normally be admitted at Chelsea and Westminster Hospital through Accident and Emergency. 3) The risks of the operative procedures, including infection and internal bleeding. 4) The possible practical difficulties collecting eggs and transferring embryos in some cases. 5) The risk of multiple pregnancy if you transfer more than one embryo. 6) The risk of miscarriage and ectopic pregnancy 7) The risk of infection, internal bleeding or a surgical complication during the egg collection 8) The risk of an allergic reaction or a side effect of the drugs 9) IMPORTANT: Remember: ovaries don t always respond to stimulation with drugs. We don t always manage to collect eggs. Eggs occasionally fail to fertilize. Not all embryos are good embryos and not all of them survive in culture. There can be no guarantee that you will have extra embryos for freezing. 8) If you do ICSI there is a slightly increased risk of congenital abnormalities of the embryo (up by 0.5%). If the sperm is extremely poor you will be advised to organize genetic tests for your partner.

Fees The costs of the treatment are outlined in the price list, which you can find on our website www.fertilityforlife.com under pricelist. Your treatment is private. You usually pay the following The standard IVF package 3450. Your drugs (you buy them separately and the prices vary depending on your protocol, dose, duration of treatment and pharmacy, but the average cost of drugs for an IVF cycle is 1000-1500. You can buy form the pharmacy at Chelsea Westminster. Alternatively, my secretary can arrange home delivery from Healthcare at Home. Any additional laboratory procedures such as blastocyst culture, embryo freezing, sperm freezing, AZH (assisted zona hatching), IMZI as above The IVF cycle starts when I do the first scan after starting the medication and finishes when we do the pregnancy test. This does not include extra consultations apart from the normal IVF scans and procedures. It does not cover early pregnancy assessments, or any emergency reviews out of hours. If you have problems in early pregnancy, such as pain or bleeding, you can see your GP or another private gynecologist or go to Casualty at Chelsea Westminster, or call the nurse line at ACU. I may not be personally available to see and examine you in early pregnancy or out of hours. If I am available, your appointment will be booked via my secretary on 07515 161 203 and will be charged separately. If the treatment is unsuccessful we normally advise you to book a review consultation, where we analyze the outcome of the treatment and advise you on your next steps. This is booked via my secretary on 07515 161 203 or the receptionist in the ACU on 0208746 8585 and is included in your treatment price. In conclusion If you do IVF without ICSI and do not do blastocyst culture or embryo freezing you will pay: 3450 for the IVF cycle + approximately 1500 for drugs This does not include your initial consultations and investigations. The treatment cycle starts when you start taking the medication and finishes when you do the pregnancy test to see if it has worked or not. If you do ICSI you will pay an additional fee, as outlined in the price-list and if you freeze embryos you will pay an extra fee for freezing and storage for one year

Cancellation fees If your IVF cycle is cancelled before egg-collection, you pay a cancellation fee of 700 plus drugs. If you have an egg collection procedure and there are no eggs, or if the eggs don t fertilize or the embryos don t survive, you pay the whole fee ( 3450 plus drugs) for your treatment as outlined above. The purpose of the cancellation fee is to cover the work of all the people who were involved in your care, up to the point that it was decided to abandon this cycle. This includes, scanning, medical advice, nursing input, administrative and secretarial work and laboratory work. The nurse consultation Before you start treatment you will need to make an appointment to meet a nurse at the ACU. Please phone ACU on 020 3315 8585 to book this appointment, which will need to be during working hours. Both you and your partner will need to attend. The nurse will have instructions from me about your treatment. If she has any queries she will ask me. In your meeting, she will cover practical aspects of your treatment, will get copies of your passports, will keep copies of your infectious screening, will ensure that you have your drugs and know how to use them. She will also ask you to fill in and sign a number of forms that are necessary for the Human Fertilization and embryology authority (HFEA). The forms that you have to fill in The nurse will ask you to fill in and sign a number of forms for the HFEA (Human Fertilization and embryology authority). These include: 1) Welfare of the child forms for both 2) HFEA forms for egg and sperm use for both 3) Consent to IVF. 4) Consent to ICSI if necessary 5) Consent to blastocyst culture 6) Consent to freezing of spare embryos All these forms will soon be uploaded on our website www.fertilityforlife.com in the Chelsea Westminster Section and you will be able to download them and fill them in before you see the nurse.

Your infectious screening All fertility Units are legally obliged to have up to date records (within 24 months) of screening for Hepatitis B, C and HIV for both of you. My secretary will offer to organize these tests for you, and you can have them done at the TDL laboratory, 55 Wimpole Street, London, or a nurse can visit you at home. The name of the profile that you need to order is FFL1 (Fertility for life 1). Alternatively, during the nurse consultation, the nurse will offer to do these tests for you. These are charged separately. If you have already done these tests you will need to bring copies of the results to the nurse, for filling in your hospital records. Please don t ask me to chase up your blood results for you (which you think you may have done at your last medical assessment at your work, or you GP etc. etc. etc. I simply don t have time to do this for you. I am very sorry. You will NOT have an egg collection if all the test results below, up to date within 24 months on the day of egg-collection, are not available and filled in the notes. This is absolutely clear. We need: Hepatitis B surface antigen for both Hepatitis B core antibody for both Hepatitis C antibody for both HIV 1, 2 antibodies for both Rubella immunity test (IgG) for the female partner. Please, note that for Hepatitis B we need both the core antibody (HBcAb) and the surface (or Australian) antigen (HBAsAg). The GPs occasionally do only the Hep B surface antigen but not the Hep B core antibody. Sometimes they do the surface antibody but not the surface antigen. So please check that you do have ALL the tests we need. If you are not sure, please liaise with the ACU nurses. Your prescription You need to ensure that you have the drugs that you need for the treatment. You have 2 options: Option1: You get a prescription when you see the nurse in the ACU and collect your drugs from the pharmacy at Chelsea Westminster. Ption 2: You have them delivered to your home by Healthcare at home. This can be arranged by contacting my secretary on 07515 161 203. My secretary will arrange for drugs to be delivered to your home address directly from Healthcare at home. We need at least 24 hours notice during working hours. However, if you

need more drugs at very short notice (i.e. the same day), or if you run out of drugs during a WE or bank holiday we wont be able to help you. Therefore you need to think ahead. As we order directly from Healthcare at Home, we have to send you the full prescription. We cannot be sure exactly how long it will take for your ovaries to be ready for egg collection. For this reason, we tend to send slightly more so that you don t run out of drugs the last minute. Unfortunately we cannot offer you a refund if you don t use the drugs for whatever reason. Once the drugs are delivered to you they cannot be returned or used for another patient. Don t run out of drugs out of hours (especially the Weekend) I will leave it up to you to ensure that you have the drugs that you need. Booking scans and appointments To book the scans during the IVF cycle you call the ACU reception on 020 8 746 8585. The scans are done by the sonographer between 830am and 1230pm Monday to Friday. After the scan you ee one of the ACU nurses and usually you have a blood test. The nurse will liaise with my consultant colleague or me and she will call you in the afternoon with instructions. Duration of appointments A treatment scan appointment as part of your IVF cycle is an appointment to do a scan. It lasts for about 10 min. Unfortunately we cannot offer you a full consultation about your possible next steps should the treatment be unsuccessful, various things you heard or read on the Internet, etc. when you come for a treatment scan. There will be other patients waiting for a scan after you. If you have other issues to discuss then you need to contact my secretary on 07515 161 203 and book an appointment for consultation and scan. This consultation will be charged separately. Your egg-collection and embryo transfer The nurses will give you specific instructions about the timing of your Ovitrelle injection and your egg eggcollection. After your egg-collection you will receive verbal and written information. Before you leave the ACU the nurse must talk to you about going home following egg collection. You will start using progesterone pessaries or cream the same night, according to my instructions. Occasionally we use intramuscular injections of progesterone.

The day after the egg collection you will be contacted by the embryologist, usually by mid-day. He/she will let you know whether any eggs have fertilized or not, how many embryos you have and he/she will give you a provisional time for embryo transfer. The earliest we do an embryo transfer is 2 days after an egg collection. The latest is 5 days after the egg collection. The average is 3 days. The reason for prolonging the culture of embryos beyond day 3 is to decide which embryos are the best ones among a number of good embryos which seem similar in quality. Deciding how many embryos to transfer and when to transfer them The day after the egg-collection the embryologist will call me to tell me how many eggs have fertilized (if any) and discuss the quality of the embryos and possible time for embryo transfer. Then he will call you and discuss the same with you. We normally check your embryos daily and decide when the best time to transfer them back is. Usually this is day 3 or day 5 following egg-collection. The final decision about the number of embryos to transfer will be made by you. We will offer you information and advice. If you have spare embryos that are suitable for freezing the embryologist will inform you. You have to tell them if you want your spare embryos to be frozen. After the embryo transfer After the embryo transfer you will take your progesterone supplements for two weeks and then do a urinary pregnancy test. You will call the nurses on 020 8 746 8585 and leave a clear message with your name and date of birth as soon as you have the test result. If the pregnancy test is positive: You will need to continue using progesterone supplements for a few more weeks and book a pregnancy scan via the ACU reception on 07515 161 203. The scan will be 2-3 weeks after your positive pregnancy test and is done by the sonographer. If you need a repeat prescription for progesterone you can collect it from ACU nurses giving some notice (ideally 48 hours) and collect the drugs from the pharmacy at Chelsea Westminster. Alternatively, you can contact my secretary and ask for a repeat prescription to be sent to your home address but we need at least 48 hours notice to do this. For such a small prescription (a box of cyclogest pessaries, for example) I much prefer that you collect it though the nurses in the ACU. I find that I get flooded with requests for repeat prescriptions or similar minor issues, all of which tend to be urgent, and I simply cannot catch up! If you have abdominal cramps, or blood spotting, or other issues, while waiting for a pregnancy test, you will call the ACU nurses and receive advice directly from them.

If the pregnancy test is negative: You will stop using the progesterone supplements and will have a period. You will call my secretary or the ACU receptionist and book a review consultation no earlier than 2 weeks after your negative pregnancy test. During this consultation we will review your treatment cycle and plan the next steps. In my experience it is better if you leave the review for at least 2 weeks after the negative pregnancy test, in order to get some rest and have time for quiet reflection before we meet again. You should expect the normal cycle of psychological and physical tiredness, disappointment, depression, sometimes guilt, anger etc. before you can have a more balanced view of things again. During this period you should try and get some rest and support each other. Seeing the counselor or accupuncturist often helps during that time. You can arrange an appointment to see the counselor by contacting the ACU reception on 020 3313 8585 or 020 8 746 8585. Time off work You will need to be off-work the day of egg-collection. You may opt to be off-work for a few days following egg-collection, as you may feel some discomfort; however this is not usually necessary. After the embryo transfer you will need to avoid swimming, coffee and alcohol, as well as strenuous exercise. Some patients arrange to take a holiday after the embryo transfer. In the past we have received requests from patients to give sick certificates for a few weeks prior to treatment for preparation and a few weeks afterwards to recover. Unfortunately we cannot do this unless something catastrophic happens and you are really poorly for all this time (which is extremely unlikely!) Who will carry out your procedures The procedures (egg collection, embryo transfer, cervical assessment, endometrial scratch etc) will be carried out by either me or one of the other doctors who work in the ACU. If you need an absolute guarantee that I will always do your procedures personally, then I am afraid you should NOT start treatment with me as I CANNOT offer this promise. Information leaflets There are several leaflets available at the ACU, covering various parts of your treatment (egg collection, embryo transfer, ICSI, assisted hatching, multiple pregnancy etc., which you can read. However, when there is any discrepancy you will do what I have advised you or you will ask me in clinic.

Support for you: Who to contact and how during the treatment For booking scan appointments for treatment you will call the ACU reception in 020 8 746 8585. For initial and follow up consultations you will call my private secretary on 07515 161 203 or the ACU reception on 020 8 746 8585. During normal working hours, if you have queries regarding your ongoing treatment you can contact the ACU nurses on 020 3315 8585. You will leave a clear message with your name and contact number and they will get back to you by end of business the same day or the next working day. The nurses can assist you for queries about your consent forms, injection technique, blood tests and similar issues that refer to the practicalities of the treatment. You should mention that you are a private patient of Mr. Nikolaou. If you have a serious problem out of hours during your IVF treatment cycle, or you feel very unwell, you must contact the nurses on the emergency number on 07768 988 182. The nurse will advise you and may contact me or my consultant colleague to discuss if necessary. Please note this option is only for genuinely urgent and important issues that cannot wait until the next working day. If you need more than advice, the nurse will advise you to go to Accident and Emergency at Chelsea and Westminster hospital and be seen and admitted on the NHS if necessary. If you have an emergency and cannot get hold of the nurse for whatever reason then you must go to A & E at Chelsea and Westminster hospital The early pregnancy care (scans, consultations etc after the positive pregnancy test) is NOT part of your IVF cycle. Please go to our website www.fertilityforlife.com at the Chelsea and Westminster page and read the instructions. Finally: As you are aware, infertility and fertility treatment can be emotionally draining. It is the same for the doctor and the nurse who deals with many infertility cases at the same time. We do need time to recharge and recover, in order to be able to help you. So, yes, call us in an emergency, but please save the other issues for when we meet in clinic, rather than by ad-hoc e-mails and messages. Often patients come to me for a consultation but then remember something else, or hear things from friends or the Internet and ask me, via my secretary, to call them to discuss. Similarly, we receive e-mails with lists of questions. Unless it is a real emergency, I am sorry but I will not call you to have a chat and I will not answer medical questions by e - mail. If this is unacceptable to you, I am very sorry but you may prefer to see

another doctor. I am not happy to offer medical advice by e-mail or text messaging or ad-hoc telephone calls. The best time to discuss your treatment with me is in my clinic, where I have your medical records, and I am physically, mentally and emotionally available to deal with your issue. Please bring your questions with you to discuss when you come to clinic. In our website we explain our normal process, particularly that more than one clinic appointment are often necessary before you are eventually ready to proceed with treatment. You must not embark on treatment, especially IVF or surgery, if you don t fully understand what you are doing, why you are doing it, and you don t feel ready and happy to proceed. If things don t go according to plan This is a journey that we travel together. On our website www.fertilityforlife.com you will see out philosophy. I would also advise you to read the poem Ithaca by K. Kavafi. Even if there is an apparent set back, there will be something positive to take from it. My intention is to help you as much as I can, but I need you to have faith and trust me otherwise the treatment may be compromised at some level. If you have any concerns please talk to me about them openly when we meet. Often patients write to me out of hours, typically on a Saturday or Sunday night, on Christmas day etc., and expect me to get back to them immediately. I will get back to you when I am ready. You may need to be a little patient unless it is a real emergency. I try my best to help but you must also understand that I can get tired both physically and emotionally. I do care. Counseling Fertility treatment can put a lot of strain on individuals and relationships for a number of reasons. More so if it is not successful. You can always speak to me. Every fertility Unit has the obligation to offer independent counseling from qualified fertility counselors. You can access this by contacting ACU reception on 020 33138585 and ask for the contact numbers of the fertility counselors. You can also visit our website www.fertilityforlife.com and go to the page: infertility investigations and treatments/support for you

Copy of your records If you need a copy of your IVF records you will contact ACU reception directly (202 8 746 8585). My private secretary is not based at the Hospital and does not have do not hold any other records about you apart from any letters that we have already sent to you. If you need my secretary to send you other packages with old letters etc., there will be an admin fee for at least 50 to cover the time of the secretary and expenses. If, for example, you are moving to another country or clinic and you need me to write a detailed report covering all your consultations and treatment, then an invoice will be raised to cover my professional time. The current rate is 180 per hour. However, my private secretary will not be able to copy your NHS- funded IVF notes. You will need to arrange this yourself by contacting the ACU reception. If you want to see me at Women s wellness centre, or elsewhere, having had NHS treatments at Chelsea Westminster previously, you will need to bring a copy of your NHS records with you at your appointment with me. My private secretary does not have access to your NHS records or test results and cannot photocopy your medical motes or transfer them out of the hospital. Similarly, if you have done blood tests and scans at Chelsea Westminster as an NHS patient, for example tests for Hepatitis and HIV, you need to contact the NHS reception and arrange for copies of your tests to be sent to you before you see me in any other location apart from Chelsea Westminster. My private secretary does not have access to your NHS records and cannot request them on your behalf, as they are confidential records of yours. Plan A and plan B Fertility treatment is often a long journey. You need to have a strategy that includes pre-treatment advice and preparation, ongoing support (including counseling and alternative therapies), the treatment itself and a plan B. Pre-treatment and co-treatment It is important to optimize your weight and health before the treatment. In some cases, I may also put you on medication to prepare your ovaries for a few months before we actually start IVF. You can also find information n our website www.fertiityforlife.com under infertility treatments/support for you Plan-A Is what treatment we are going to try, how many attempts each and when. Usually I recommend that you plan at least 3 IVF attempts, even if you eventually only need one! This creates a psychological safety net that is very useful in case the first cycle is cancelled or is not successful. Having the net underneath increases the chance of the treatment being successful.

If your first IVF cycle is unsuccessful you must book a review consultation with me before you plan your next step. This is booked normally via my secretary on 07515 161 203 or the ACU receptionist on 020 8 746 8585. Let things cool off a little. You normally want to discuss with me immediately once your pregnancy test is negative. This is understandable. You need reassurance that you can still have babies and your fertility has not reached a sudden and irreversible end. However, it is far better to wait for a couple of weeks before we actually meet. This will allow me to consider your case, to receive the details of the laboratory observations on your gametes and embryos, and you to have some perspective. There is huge variability in all human characteristics and your ovarian response to stimulation, quality of embryos etc. will vary from cycle to cycle. The cumulative success of IVF treatment increases in the first 4-6 attempts. We normally recommend a break of 2 months between attempts, to let you recover both physically and emotionally. Plan B is what happens if all treatments fail. You need to make an appointment to discuss with me about your plan B, including being fertile without necessarily having your own biological children, or egg donation. Having considered this possibility helps people cope better with fertility treatment. Where can you see me For all private consultations you should call my secretary on 07515 161 203. Chelsea/Westminster private outpatients, 4 th floor, 369 Fulham road, London SW10: Appointments are Wed pm 2-5 and 6-8. Please, don t e mail me directly to try and book an appointment! I don t carry my diary with me and cannot do this for you. You need to call my secretary and tell her what you need: For example, if you need a consultation, book a consultation. This normally lasts for 60 min for new and 30min for follow up. If you need longer time, you need to book a long consultation If you need a scan, book a scan (not all rooms have a scanning machine and we need to know what you need in order to book this). If the scan is part of an ongoing IVF cycle for which you have paid a package fee, you need to clarify that it is a treatment scan, part of the IVF cycle, otherwise my secretary will book the wrong slot and you will receive a bill!

If you need a test for your fallopian tubes (HysoSY), you need to explain this to the secretary. If you expect me to have previous records for you or results of tests, you need to mention it to the secretary so that it can be organized for you. I hope the above information is clear and the treatment will run smoothly for you. Good luck! DIMITRIOS NIKOLAOU and the team at Fertility for life.