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Product-friendly and fast......vacuum Heating and Drying Ovens V V T Optimum drying results under exceptional conditions

Drying in a vacuum... The Advantages No doubt, there are various ways of drying your product. You should decide on the vacuum drying ovens VVT of Vötsch... Heat-sensitive mediums (e. g. pharmaceutical products) are dried with care Reduced drying times by lowering the pressure Due to the extremely low remaining oxygen content in the drying oven there are no oxidation processes Evaporating fluids (e. g. solvents) can be recovered Optimum drying conditions for light, powdery products as there is no turbulence (no convection) No skin-forming on the product being dried; therefore constant drying performance Graph showing state of water Economic because steam or warm water from other processes can be used as a heat medium Flexible heating. Pressure (mbar) 10 2 Graph showing state of water Solid Liquid 10 1 10 0 Evaporating Gaseous 10-1 10-2 10-3 -60-40 -20 0 20 40 60 80 100 Temperature in C 2

...more multi-faceted than you think Range of Application You can dry products from almost all branches of industry in a vacuum drying oven, e. g.: Pharmaceutical industry Chemical industry Cosmetics industry Food processing industry Electrical and electronic engineering Precision engineering and optics Aerospace industry Research and development Microstructure techniques Nanotechniques Plastics and ceramics Textiles Surface techniques State your special requirements we will carry out preliminary experiments for you. 3

Construction... Design Our vacuum drying ovens are of compact design. The major components are: - Drying oven with shelves - Heating and cooling aggregate for the thermal medium - Vacuum pump - Condenser with storage vessel. Heating Modes Electrical Warm water Thermal oil Steam Infrared radiation Microwave (HF) Testing We seal test our vacuum drying ovens and supply you with a test certificate. Safety Devices Pressure-relief valve Temperature limiter Construction Features All components of the drying oven itself are of stainless steel with material class 1.4571 as these may come into contact with the product. The external housing and reinforcements are made of stainless steel with the material class 1.4301. The interior of the drying oven is designed in compliance with GMP-/FDA regulations. This is important when the product being dried should on no account react to other substances or when product entrainment shall be prevented during loading/unloading. Inspection glass (200 mm diameter) in the door Heat-resistant silicon seal in the door Seals can be easily replaced when necessary Double-jointed hinge to ensure that the door closes tightly and prevents overwearing the seals Additional flanges are provided for special applications. Temperature Range The maximum rated temperatures that can be reached at the product being dried depend on the mode of heating used for the drying oven. Mode of Maximum Heating Temperature in C Electric 200 / 400 Warm water 95 / 140 Thermal oil 200 / 250 Steam according to the steam pressure A Thermostat B Vacuum drying oven C Condenser system D Vacuum pump 1 Heated shelf 2 Distribution system inflow 3 Distribution system feedback 4 Thermostat 5 Condenser 6 Storage vessel 4 Vacuum Heating and Drying Ovens VVT 125/170 WW-GMP

...and design Heating Modes We offer four heating solutions: - Electrical - With heating medium - Infrared radiation - Microwave (HF). The first two processes are based on the principle of contact heating. This means that the heat is conducted from the heat medium through contact areas to the product. With the electrical version, tubular heaters are fed in coils through the hollow shelves (sandwich construction). With the version using heat medium you have three possibilities: - Warm water - Thermal oil - Steam. If you wish to heat using a heat medium, we equip the drying oven with pressure-tight, hollow shelves. The difference from the electrical version is that the heat transfer medium flows through channels and then fills the entire cavity of the shelf. A separate thermostat controls the temperature of the heat medium. The heated medium is pumped in a cycle through the individual shelves. With the steam heating version a special valve is responsible for controlling the amount of steam. This control operates without auxiliary power so that it is possible to use this type of control in an explosion-proof room. With steam it is possible to heat in two different ways, the temperature of the steam being important: - When T <100 C the steam is routed into a heat exchanger where the heat energy of the steam is transferred to the water. The heated water is pumped through the shelves. - When T is >100 C the steam is fed into the distribution system for the shelves. Vacuum Heating and Drying Oven VVT 110/170 EA (jacket heating) Vacuum Pump A standard feature of our vacuum drying ovens are the oil-sealed, slide vane rotary vacuum pumps. Condenser The condenser enables large amounts of humidity to be recovered which is particularly important when using hazardous solvents. An additional advantage: condensation accelerates drying. Use with potentially explosive products and in hazardous locations Our vacuum drying ovens are explosion-protected when... - the vaccum drying oven is to be installed in an area where there is risk of explosion - the fluid of your product being dried is easily inflammable. Options/Accessories Use of special materials for all components that come into contact with evaporating fluids (e. g. Inconel, Hasteloy) Combination with recirculation air for heating up of products at normal atmosphere Design in accordance with GMP-/FDA Qualification documents are issued as verification of our tests In order to avoid condensation in the drying oven, the door and walls can be heated Pneumatically-controlled doors for the automatic loading of the drying oven Designed for high-vacuum processes Special dimensions Special vacuum pumps S!MPATI* Software (refer to page 6) Digital pressure display Pressure control in conjunction with a solenoid valve in the suction line Temperature sensor for product being dried Nitrogen supply for quick extraction of released vapour For aggressive solvents: door seals of viton or with FEP cover External housing with surrounding frame for installation in wall. 5

Operating and controlling... Operating and controlling with All Vötsch dry heat sterilisers are equipped with the operating and control system. The is a self-controlling, digital measuring and control system. The input of process parameters and programmes, as well as the output of actual values, operating and error messages, is carried out by means of a touch-panel. Comfortable input of process values and programme operation, with graphic presentation of the set and actual values by means of the touch-panel Programme memory for up to 100 programmes, with a total of 1,000 sections Two-level password protection against unauthorised access Integrated limit value temperature control system Serial interfaces RS 232 C and RS 485, Ethernet Operating and failure messages are shown on the colour touch-panel Compatible with Vötsch PC software package, for convenient administration and archiving data records Special user interface for application in a production environment (simplified process start/stop mode). Vötsch PC software package The Vötsch software ensures a complete documentation and graphical evaluation If installed in an optional notebook or PC, the user can create programme profiles and document all process parameters. Parallel to this, the user can make full use of the PC s performance. Software advantages: Up to 99 units can be networked Programming and selection of programmes for automatic processes; no costly programming required Not only operating and control but also documentation, visualisation and administration of sterilisation process data Print graphical presentation of process data and copy into other programmes. Internal interfaces ensure compatibility (with Microsoft Word, Microsoft Paint, Microsoft Excel, National Instruments Labview) Access via PC network and your Internet browser Transfer of messages per e-mail to an available mail-server (SMTP) Reads programmes, production data (product, operator, unit) via bar code (optional) Conforms with FDA 21 CFR, part 11. 6

...the Technical Data Series VVT 65/50 VVT 65/85 VVT 85/85 VVT 85/110 VVT 85/170 Nominal temperature C 200 200 200 200 200 Internal dimensions A Width mm 660 660 860 860 860 B Height mm 550 850 850 1100 1700 Depth mm 735 735 1050 1050 1050 Volume litre 260 418 758 980 1515 Shelves Width mm 650 650 850 850 850 Depth mm 650 650 950 950 950 Height above shelves 1) mm 130 130 130 120 130 No. of shelves (standard) 3 5 5 7 10 Available surface (standard) m 2 1.25 2.10 4.00 5.60 8.00 No. of shelves (max.) 5 8 8 10 16 Available surface (max.) m 2 2.10 3.30 6.40 8.00 12.90 External dimensions D Width mm 1,140 1,140 1,340 1,340 1,080 E Height mm 825 1,125 1,125 1,375 - H Height mm 1,450 1,750 1,750 2,000 2,000 Depth mm 1,115 1,115 1,430 1,430 1,430 Substructure height G mm 625 625 625 625 - Temperature distribution on the shelves K ±3 ±3 ±4 ±4 ±4 Heating capacity kw 3 5 10 14 20 Heating capacity with max. no. of shelves kw 5 8 16 20 32 Power supply 3/(N)/PE AC 400 V ±10 %, 50 Hz 3) Suction connections DN 40 KF 40 KF 40 KF 65 ISO-K 65 ISO-K + small flange DN 10 KF 10 KF 10 KF 10 KF 10 KF Ultimate vacuum 2) mbar 1 x 10-2 1 x 10-2 1 x 10-2 1 x 10-2 1 x 10-2 Weight, approx. kg 800 950 1,300 1,500 1,900 1) With electrically heated shelves minus 5 mm. 2) The ultimate vacuum depends on the type of pump used. 3) Other voltages and frequencies as option. We reserve the right to make technical alterations. Controlelements Controlelements Shelf Shelf Shelf Shelf 7

Standard and customised solutions... Standard and customised solutions to your special applications Heating and drying cabinets Vacuum, heating and drying ovens Clean air, heating and drying ovens Explosion-proof drying ovens Tempering ovens up to 750 C Chest ovens for easy top loading Drawer-type ovens Walk-in ovens and systems for continuous heating processes Hot air sterilisers for normal and clean air conditions Charging systems e. g. charging trolleys, transport trolleys and wire meshed shelves Heating options Electrical, gas, infrared, microwave, warm water, steam, thermal oil For process documentation as per EN ISO 9001 we offer a variety of accessories and software for controlling, monitoring and documenting. Networking of up to 99 systems via one PC station. Vacuum, heating and drying ovens VVTD 85/170/125 E-GMP Competence and dedication to customers... Individual consultation Engineering and development Production and assembly Commissioning and briefing Calibration in own laboratory Maintenance, spare parts service, repairs Recycling of redundant units Training and workshops Further information and representatives world-wide see www.voetsch.info Product Range Heat Technology Vötsch Industrietechnik GmbH Umweltsimulation. Wärmetechnik Greizer Strasse 41 49 35447 Reiskirchen-Lindenstruth Germany Phone +49 (0) 64 08 / 84-73 Fax +49 (0) 64 08 / 84-87 47 info-wt@v-it.com www.v-it.com www.voetsch.info DIN EN ISO 9001 D-Nr. VVT0.0.2/53062