Laboratory water purification systems

Laboratory water purification systems

Choosing a water purification system Application ISO 3696 classification Suggested model and configuration Page Feed water for labware washers Sterifeed 20 Feed water for autoclaves Grade 3 Crystal 7 RO 18 Glassware rinsing RO 15 Feed water for automated biochemistry analyzers General laboratory work Electrochemistry Flame AAS Wet chemistry Spectrophotometry Buffer and media preparation Reagent preparation Ion chromatography ICP-MS Grade 2 Crystal Clinic 22 Grade 2 Grade 1 Crystal 7 Pure 18 Pure 15 Crystal B Pure 10 Trace 12 Graphite AAS ICP-OES Crystal B Trace 3 12 Gas chromatography Grade 1 Crystal B 3 Integrity 6 TOC measurements Onsite 8 cytometry Bio 12 Cell and tissue culture Grade 1 Crystal B Bio 3 Integrity Bio 6 Molecular biology Onsite Bio 8 2

systems Crystal B series Crystal B ultrapure systems are multi-purpose water purification systems. The Crystal B systems produce ultrapure and pure water directly from tap water. Crystal B Ultrapure systems are available in the following configurations: Crystal B Trace (P/N CB-1015) produces water for inorganic trace analysis. Water can be used for atomic absorption spectrometry (with graphite furnace atomizer), ICP-OES analysis, ICP-MS and other inorganic analytical methods. Crystal B (P/N CB-1101) produces water with very low organic carbon (TOC) content meeting requirements of liquid chromatography methods. Crystal B water can also be used for some microbiological and molecular biology appli cations. Crystal B Bio (P/N CB-1201) system produces water with very low organic and RNase/DNase content that is intended for the use in molecular biology, including RNase-sensitive applications. Any configuration of a Crystal B ultrapure system produces both ultrapure and pure water. Ultrapure (Grade 1) water is d through the point-of-use on the front panel. Pure (Grade 2) water is d directly from the storage. Crystal B ultrapure water can be used for the most demanding appli cations including, but not limited to: inorganic trace analysis liquid chromatography cell culture molecular biology With resistivity of 18.2 Mega- Ohm*cm (0.055 μs/cm) ultrapure water produced by a Crystal B system exceeds requirements of all relevant standards (ISO 3696 Grade 1, ASTM Type I, CLSI Type I). Purified water is collected in a storage. An integrated recirculation system ensures consistent of water and reduces total organic carbon (TOC) to very low levels: <2ppb for and Bio configurations and 5-10 ppb for the Trace configuration. produced by the Crystal B systems complies with the requirements of ISO 3696 Grade 2 water and can be used for labware washing, wet chemistry methods, flame spectrophotometers, etc. The rate of ultrapure water is 2 L/min. Whereas the rate of pure water is 4 L/min. All Crystal B systems have a controller with a graphic LCD display for water indication. The LCD display provides all necessary information about system status, as well as the remaining life and deionization (DI) performance. The smart DI monitoring system also provides a reduction in running costs. A user is instructed to replace the DI only when the is near the end of its service life. If a Bluetooth option (P/N 10103) is installed, the controller can be detached, so the Crystal B system can be controlled remotely. If spacesaving is crucial, wall-mounting the Crystal B, and the use of a remote control is the right choice. All cartridges and s are easily accessible and no tools are required to replace them. The Crystal B system can be installed on a laboratory bench or mounted on a wall. The Crystal B has important safety functions: filling control tap water pressure control protection from failure The Crystal B systems include: Pre- set Deionization Final stage polishing 25L storage with an integrated Grade II dispensing system Point-of-use final (0.22 μm micro for the Crystal B Trace and systems) Ultra for the Crystal B Bio systems; and/or a photo-oxidation for elimination of organics ( and Bio configurations) UV sterilization (Bio configuration) 3

diagrams (RO ) Deionization Shunting Final point of-use Check Polishing Protective Ultrapure water Pure (Grade 2) water Crystal B Trace (RO ) Deionization Shunting Polishing Final point of-use Check Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Pure (Grade 2) water Crystal B (RO ) Check Deionization UV sterilization (254 nm) Shunting Polishing Final point of-use Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Pure (Grade 2) water Crystal B Bio 4

Applications Application Crystal B Trace Crystal B Crystal B Bio Reagent preparation Ion chromatography ICP-MS Atomic absorption spectrophotometry with graphite atomizer ICP-OES Gas chromatography Total Organic Carbon measurement cytometry Cell and tissue culture Molecular biology Components 10019 10310 Accessory Pre- set for chlorine and organics reduction Crystal B Trace Crystal B Crystal B Bio + + + + + + + + + Deionization, standard + + + 10029 Polishing + + + 10105 Photo-oxidation + + 10012 Point-of-use micro + + 10109 Point-of-use ultrafiltration + 10102 UV sterilization + 10106 Integrated TOC monitor option 10103 Removable controller with Bluetooth option option option Specifications Purified water specifications Crystal B Trace Crystal B Crystal B Bio Pure (Grade 2) water resistivity >10 MΩ x cm >10 MΩ x cm >10 MΩ x cm Pure (Grade 2) water conductivity <0.1 μs/cm <0.1 μs/cm <0.1 μs/cm Ultrapure (Grade 1) water resistivity 18.2 MΩ x cm 18.2 MΩ x cm 18.2 MΩ x cm Ultrapure (Grade 1) water conductivity 0.055 μs/cm 0.055 μs/cm 0.055 μs/cm TOC 5 10 ppb <2 ppb <2 ppb RNase <0.01 ng/ml DNase <4 pg/μl Bacteria < 1 cfu/ml < 1 cfu/ml < 1 cfu/ml Endotoxins <0.15 EU/mL <0.15 EU/mL < 0.001 EU/mL icles > 0.22 μm <1/ per ml <1/ per ml <1/ per ml Nominal flow, pure water (to storage ) 10 L/h 10 L/h 10 L/h Nominal flow, ultrapure water 2 L/min 2 L/min 2 L/min Nominal flow, pure water 4 L/min 4 L/min 4 L/min Deionization life (standard ) 1 m 3 1 m 3 1 m 3 Recovery >30 % >30 % >30 % Dimensions (WxDxH), cm 50x40x60 50x40x60 50x40x60 25 L 25 L 25 L Tank dimensions (WxDxH), cm 30x25x50 30x25x50 30x25x50 Feed water pressure 0.5 5 bar 0.5 5 bar 0.5 5 bar Feed water conductivity < 900 μs/cm < 900 μs/cm < 900 μs/cm Ordering Information Model Crystal B Trace CB-1015 Crystal B CB-1101 Crystal B Bio CB-1201 Consumables Description Replacement criteria Comments 10019 Replacement set, Crystal B Filter life counter is zero or the is clogged 10310 Replacement deionization DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm 10029 Replacement polishing Every 1 2 years, depending on operation 10011 Replacement sterilization UV bulb As required (on average every 3 years) Bio systems only 10018 Replacement photooxidation UV bulb As required (on average every 3 years) and Bio systems 10012 Replacement 0.22 μm micro Every 6 12 months Trace and systems 10120 Replacement ultra Every 6 12 months Bio systems only 5

systems Integrity series Crystal Integrity systems produce ultrapure water directly from tap water. produced by the Crystal Integrity system complies with the requirements for Grade 1 water in accordance with relevant standards (ISO 3696, ASTM, CLSI). The Crystal Integrity systems are recommended for laboratories with relatively low consumption of ultrapure water (about 5 litres per day). Crystal Integrity systems are available in the following configurations: Integrity System (P/N CB-1503) produces water with very low organic carbon (TOC) content. This meets the re quirements for liquid chromatography methods. Integrity water can also be used for some microbiological and molecular biology appli cations. Applications Application Consumables Integrity Bio System (P/N CB- 1505) produces water with very low organic and RNase/DNase content. This is intended for use in molecular biology, including RNase-sensitive applications. Crystal Integrity water is intended for the most demanding applications including, but not limited to: inorganic trace analysis liquid chromatography cell culture molecular biology produced by an Integrity system, with resistivity of 18.2 MegaOhm*cm (0.055 μs/cm), exceeds requirements of all relevant standards (ISO 3696 Grade 1, ASTM Type I, CLSI Type I). Purified water is collected in an integrated storage. The recirculation system ensures consistent of water and reduces total organic carbon (TOC) to very low levels: <2ppb. Space-saving, integrated, 5L is made of high density polyethylene to minimize contamination. The storage is accessible for cleaning. Integrity Integrity Bio Reagent preparation Ion chromatography ICP-MS Atomic absorption spectrophotometry with graphite atomizer ICP-OES Gas chromatography Total Organic Carbon measurement cytometry Cell and tissue culture Molecular biology Components Accessory All Integrity systems have a controller with a graphic LCD display for water indication. The LCD display provides all necessary information about system status, remaining life, and polishing performance. The smart polishing monitoring system provides a reduction in running costs. Users are instructed to replace the polishing only when the is close to the end of its service life. If a Bluetooth option (P/N 10103) is installed, the controller can be detached. The Integrity system can be controlled remotely for more convenient operation. All cartridges and s are easily accessible and no tools are required to replace them. The Integrity system can be installed on a laboratory bench or mounted on the wall to save space. The Crystal Integrity has important safety functions, including: filling control tap water pressure control Integrity Integrity Bio Description Replacement criteria Comments 10019 Replacement set, Integrity Filter life counter is zero or the is clogged 10029 Replacement polishing DI Err message is shown, or water conductivity while dispensing is consistently > 0.1 μs/cm 10011 Replacement sterilization UV bulb As required (on average every 3 years) Bio systems only 10018 Replacement 0.22 μm micro As required (on average every 3 years) and Bio systems 10012 Replacement 0.22 μm micro Every 6 12 months systems only 10120 Replacement ultra Every 6 12 months Bio systems only 10019 Pre- set for chlorine and organics reduction reduction + + + + 10029 Polishing + + 10105 Photo-oxidation + + 10012 Point-of-use micro + 10109 Point-of-use ultrafiltration + 10102 UV sterilization + 10106 Integrated TOC monitor option 10103 Removable controller with Bluetooth option option 6

diagrams (RO ) Shunting Polishing Final point of-use Check Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Integrity (RO ) UV sterilization (254 nm) Shunting Polishing Final point of-use Check Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Integrity Bio Specifications Purified water specifications Integrity Integrity Bio Ultrapure (Grade 1) water resistivity 18.2 MΩ x cm 18.2 MΩ x cm Ultrapure (Grade 1) water conductivity 0.055 μs/cm 0.055 μs/cm TOC <2 ppb <2 ppb RNase <0.01 ng/ml DNase <4 pg/μl Bacteria < 1 cfu/ml < 1 cfu/ml Endotoxins <0.15 EU/mL < 0.001 EU/mL icles > 0.22 μm <1/ per ml <1/ per ml Nominal flow, pure water (to storage ) 4 L/h 4 L/h Nominal flow, ultrapure water 2 L/min 2 L/min Polishing life 1 m 3 1 m 3 Recovery >30 % >30 % Dimensions (WxDxH), cm 50x40x60 50x40x60 Integrated storage 5 L 5 L Feed water pressure 1.5 5 bar 1.5 5 bar Feed water conductivity < 900 μs/cm < 900 μs/cm Ordering Information Model Crystal Integrity Crystal Integrity Bio CB-1503 CB-1505 7

systems Onsite series Adrona Onsite systems produce ultrapure water from pre-treated water. produced by the Adrona Onsite complies with the requirements for Grade 1 water for all relevant standards (ISO 3696, ASTM, CLSI). Adrona Onsite systems are recommended for laboratories with consumption of ultrapure water of 5-10 litres per day. Adrona Onsite systems are available in following configurations: Onsite System (P/N CB- 1803) produces water with very low organic carbon (TOC) content. This meets the requirements of liquid chromatography methods. Onsite water can also be used for some microbiology and molecular biology applications. Onsite Bio System (P/N CB- 1805) produces water with very low organic and RNase/DNase content. This is intended for use in molecular biology, including RNase-sensitive applications. Water produced by Adrona Onsite systems is intended for most demanding applications including, but not limited to: inorganic trace analysis liquid chromatography cell culture molecular biology produced by an Integrity system, with resistivity of 18.2 MegaOhm*cm (0.055 μs/cm), exceeds requirements of all relevant standards (ISO 3696 Grade 1, ASTM Type I, CLSI Type I). Crystal Onsite systems have integrated sto - rage. The storage should be filled with pre-treated water by the operator. Pre-treated water may be obtained from a water still, or a reverse system. The Crystal Onsite system comes with a 5L carboy. The carboy has a stopcock and handle for convenient transportation of water from a water still to the Crystal Onsite unit. The recirculation system ensures a consistent of water and reduces total organic carbon (TOC) to a very low level: <2ppb. A space-saving, integrated, 5L is made of high-density polyethylene to minimize contamination. The 5L is accessible for cleaning. All Crystal Onsite systems have a controller with a graphic LCD display for water indication. The LCD display provides all the necessary information about system status, remaining life, and the polishing performance. The smart polishing monitoring system provides a reduction in running costs. The user is instructed to replace the polishing only when the is close to the end of it s service life. If a Bluetooth option (P/N 10103) is installed, the controller can be detached. The Onsite system can be controlled remotely for convenient operation. The Crystal Onsite has important safety functions including filling control. All cartridges and s are easily accessible and no tools are required to replace them. The Onsite system can be installed on a laboratory bench or mounted on the wall to save space. Applications Application Onsite Onsite Bio Reagent preparation Ion chromatography ICP-MS Atomic absorption spectrophotometry with graphite atomizer ICP-OES Gas chromatography Total Organic Carbon measurement cytometry Cell and tissue culture Molecular biology Components Accessory Onsite Onsite Bio 10029 Polishing + + 10105 Photooxidation + + 10012 Point-of-use micro + 10109 Point-of-use ultra filtration + 10106 Integrated TOC monitor option 10103 Removable controller with Bluetooth option option 8

diagrams Shunting Polishing Final point of-use Shunting Polishing Final point of-use Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Onsite Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Onsite Bio Specifications Purified water specifications Onsite Onsite Bio Ultrapure (Grade 1) water resistivity 18.2 MΩ x cm 18.2 MΩ x cm Ultrapure (Grade 1) water conductivity 0.055 μs/cm 0.055 μs/cm TOC <2 ppb <2 ppb RNase <0.01 ng/ml DNase <4 pg/μl Bacteria < 1 cfu/ml < 1 cfu/ml Endotoxins <0.15 EU/mL < 0.001 EU/mL icles > 0.22 μm <1/ per ml <1/ per ml Nominal flow, ultrapure water 2 L/min 2 L/min Polishing life 1 m 3 1 m 3 Recovery >30 % >30 % Dimensions (WxDxH), cm 50x40x60 50x40x60 Integrated storage 5 L 5 L Feed water conductivity < 15 μs/cm < 15 μs/cm Ordering Information Model Crystal Onsite CB-1803 Crystal Onsite Bio CB-1805 Consumables Description Replacement criteria Comments 10029 Replacement polishing DI Err message is shown, or water conductivity while dispensing is consistently > 0.1 μs/cm 10018 Replacement 0.22 μm micro As required (on average every 3 years) and Bio systems 10012 Replacement 0.22 μm micro Every 6 12 months systems only 10120 Replacement ultra Every 6 12 months Bio systems only 9

systems Crystal B Pure series The Crystal B Pure systems produce purified water for general laboratory applications and analytical inorganic methods. Crystal B complies with the requirements of ISO 3696 Grade 2. The costs of production are lower in comparison to the costs of. Pure (Grade 2) water complies with the requirements of a variety of applications, including: Many inorganic methods of analysis (e. g. flame spectrometry) Wet chemistry methods Electrochemistry Labware washing, etc. The Crystal B Pure systems are designed to provide a lab with water that is essentially free from dissolved ions and has a low TOC content. The conductivity of Crystal B is less than 0.1 μs/ cm. This exceeds the requirements for Grade 2 water put forth in ISO 3696. Applications Application Glassware rinsing Laboratory washers Autoclaves Electrochemistry Flame AAS Wet chemistry Spectrophotometry Buffer and media preparation Crystal B Pure 10 Crystal B Pure systems are equipped with a user-friendly control. The control has a graphic LCD display with indication of water. The Bluetooth option (P/N 10103) provides remote control of the Crystal B system via the detachable controller. The Crystal B system can be installed on a wall or under a bench, thus saving valuable laboratory space. The controller provides information about the system status; including remaining life and deionization (DI) performance. The smart DI mo- Specifications Purified water specifications Crystal B Pure Purified water resistivity >10 MΩ x cm Purified water conductivity <0.1 μs/cm icles > 0.22 μm <1 per ml Nominal flow, pure water (to storage ) 10 L/h Dispense flow, pure water 4 L/min Deionization life (standard ) 1 m 3 Recovery >30 % Dimensions (WxDxH), cm 50x40x60 (option) 25 L 300 L Feed water pressure 0.5 5 bar Feed water conductivity < 900 μs/cm

dule monitoring system provides a reduction in running costs. The user is instructed to replace the DI only when the is near the end of it s service life. diagram Crystal B Pure A storage for purified water is available as an option. We offer storage s with capacities ranging from 10L 60L. All s with a capacity of 25L and higher have integrated s for fast and convenient dispensing. The dispensing flow rate is 4 L/min. An integrated enables placement of the storage under a bench, if desired, to save more space. The Crystal B has important safety functions, including: Tank filling control, tap water pressure control, and protection from failure. (RO ) Check Deionization Pure (Grade 2) water The Crystal B systems include: Pre- set Deionization A UV sterilization is available as an option (P/N 10102). Ordering Information Model Components Accessory Crystal B Pure 10019 Pre- for chlorine and organics reduction + + + 10310 Deionization, standard + Crystal B Pure CB-1005 10102 UV sterilization option 10103 Removable controller with Bluetooth option s 11000 Accessory Basic w/, 25L Crystal B Pure option 11014 Tiny, 10L option 10007 10004 Comfort w/, 60L Economy w/, 50L option option Consumables 10019 10310 10011 Description Replacement criteria Comments Replacement set, Crystal B Replacement deionization Replacement sterilization UV bulb Filter life counter is zero or the is clogged DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm As required (on average every 3 years) Systems with 10102 option only 11

ULTRAPURE WATER SYSTEMS series 12 The ultrapure systems are economy class, multi-purpose, water purification systems. ultrapure water systems are available in the following configurations: Trace System (P/N CE- 1001) produces water for inorganic trace analysis. This water is recommended for atomic absorption spectrometry (with graphite furnace atomizer), ICP- OES analysis, ICP-MS and other inorganic analytical methods. System (P/N CE- 1101) produces water with very low organic carbon content (TOC) to comply with the requirements of liquid chromatography methods. water can also be used for some microbiological and molecular biology applications. Bio System (P/N CE- 1201) produces water with very low organic and RNase/DNase content, intended for molecular biology, including RNase-sensitive applications. All systems produce two types of water: Ultrapure (ISO 3696 Grade 1) and Pure (ISO 3696 Grade 2). produced by the systems has resistivity 18.2 MegaOhm*cm (conductivity 0.055 μs/cm). This exceeds requirements of all the relevant standards (ISO 3696 Grade 1, ASTM Type I, CLSI Type I). Purified water is collected in a storage. The recirculation system ensures a consistent of water, and a low level of organic carbon content (TOC). TOC is <2ppb for and Bio configurations; and 5-10 ppb for the Trace configuration. The dispensing rate of high-, is 2 L/min. produced by systems can be used for labware washing, wet chemistry methods, flame spectrophotometers, etc.. is d directly from the storage. The dispensing flow rate of is 4 L/min. All systems have a graphic LCD display that provides a clear water readout. The display also provides information about the system status. This includes current resistivity and remaining pre service life. The smart deionization (DI) performance monitoring system provides a reduction in running costs. All cartridge and replacement can Ordering Information Model Trace Bio CE-1001 CE-1101 CE-1201 be done by the operator and no tools are required. The systems include important safety functions, such as: filling control tap water pressure control protection from a failure Running costs can be decreased even more by installing an 8L deionization option (P/N 10101). systems include: Pre- RO Deionization Polishing 25L storage with integrated Grade 2 dispensing system Point-of-use Final Filter: 0.22 μm micro for Crystal E Trace and systems ultra for Bio systems Photo-oxidation for reduction of organics (for and Bio configurations) UV sterilization (for the Bio configuration)

diagrams (RO ) Deionization Shunting Final point of-use Check Polishing Protective Ultrapure water Pure (Grade 2) water Trace (RO ) Deionization Shunting Polishing Final point of-use Check Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Pure (Grade 2) water (RO ) Deionization UV sterilization Check (254 nm) Shunting Polishing Final point of-use Protective Dual wavelength UV photooxidation (185/254 nm) Ultrapure water Pure (Grade 2) water Bio 13

14 Components 10009 10310 10101 Consumables 10009 10310 10113 10029 10011 10018 10012 Accessory Trace Description Replacement criteria Comments Replacement, Replacement deionization Replacement high-capacity deionization Replacement polishing Replacement sterilization UV bulb Replacement photooxidation UV bulb Replacement 0.22 μm micro Bio Pre- for chlorine and organics reduction + + + + + + + + + Deionization, standard + + + High capacity deionization, (replaces standard option option option ) 10029 Polishing + + + 10105 Photo-oxidation + + 10012 Point-of-use micro + + 10109 Point-of-use ultrafiltration + 10102 UV sterilization + Filter life counter is zero or the is clogged DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm Every 1 2 years, depending on operation As required (on average every 3 years) As required (on average every 3 years) Systems with 10101 option only Bio systems only and Bio systems only Every 6 12 months Trace and systems 10120 Replacement ultra Every 6 12 months Bio systems only Specifications Applications Application Trace Bio Reagent preparation Ion chromatography ICP-MS Atomic absorption ICP-OES Gas chromatography Total Organic Carbon cytometry Cell and tissue culture Molecular biology Purified water specifications Trace Bio Grade 2 water resistivity >10 MΩ x cm >10 MΩ x cm >10 MΩ x cm Grade 2 water conductivity <0.1 μs/cm <0.1 μs/cm <0.1 μs/cm Grade 1 water resistivity 18.2 MΩ x cm 18.2 MΩ x cm 18.2 MΩ x cm Grade 1 water conductivity 0.055 μs/cm 0.055 μs/cm 0.055 μs/cm TOC 5 10 ppb <2 ppb <2 ppb RNase N/A N/A <0.01 ng/ml DNase N/A N/A <4 pg/μl Bacteria < 1 cfu/ml < 1 cfu/ml < 1 cfu/ml Endotoxins <0.15 EU/mL <0.15 EU/mL < 0.001 EU/mL icles > 0.22 μm <1 per ml <1 per ml <1 per ml Nominal flow, pure water (to storage ) 10 L/h 10 L/h 10 L/h Nominal flow, ultrapure water 2 L/min 2 L/min 2 L/min Nominal flow, pure water 4 L/min 4 L/min 4 L/min Deionization life (standard ) 1 m 3 1 m 3 1 m 3 Deionization life (high capacity ) 3 m 3 3 m 3 3 m 3 Recovery >30 % >30 % >30 % Dimensions (WxDxH), cm 40x35x55 40x35x55 40x35x55 25 L 25 L 25 L Tank dimensions (WxDxH), cm 30x25x50 30x25x50 30x25x50 Feed water pressure 0.5 5 bar 0.5 5 bar 0.5 5 bar Feed water conductivity < 900 μs/cm < 900 μs/cm < 900 μs/cm

systems Pure and RO series RO and Pure systems produce purified water of ISO 3696 Grade 3 (RO) and ISO 3696 Grade 2 (Pure). Pure and RO water have much lower production costs than ultrapure (Grade 1) water. Pure and RO water comply with the requirements of a variety of applications, including: Many inorganic methods of analysis (e. g. flame spectrophotometry) Wet chemistry methods Electrochemistry Labware washing, etc. The RO system reduces contamination in water by more than 98%. The conductivity of RO purified water is typically less than 5 μs/cm (dependent Specifications upon feed water). The Pure system produces water that is essentially free from inorganic contamination, and low in TOC content. The conductivity of water produced by the Crystal E Pure system is less than 0.1 μs/ cm. This exceeds the requirements for Grade 2 water according to ISO 3696. s of various sizes are available as an option for the Pure water system. The capacity of the s range from 10L to 300L. All s with a capacity of 25L or higher have integrated s for fast and convenient dispensing. The dispensing flow rate is 4 L/min. An integrated allows placement of the storage under a bench, if needed, to save space. The RO and Pure have a graphic LCD display providing indication of water, system status, and remaining life. The smart DI performance monitoring system provides a reduction in system running costs. All cartridge and replacement can be done by the operator without tools. The provides important safety functions, including: filling control tap water pressure control protection from failure. High-Consumption Laboratories and Applications: We offer the 20 Pure system for high consumption (30 L/day and more) applications. This includes a high capacity (8L) deionization. The high capacity provides a reduction in system running costs. It is also possible to order 8L option (P/N 10101) for the Crystal E Pure system. The systems include: Pre- Deionization (for Pure systems only) A UV-sterilization is available as an option (P/N 10102). Purified water specifications RO 20 Pure Pure Purified water resistivity >10 MΩ x cm >10 MΩ x cm Purified water conductivity <5 μs/cm <0.1 μs/cm <0.1 μs/cm icles > 0.22 μm <1 per ml <1 per ml <1 per ml Nominal flow, pure water (to storage ) 10 L/h 20 L/h 10 L/h Dispense flow, pure water 4 L/min 4 L/min 4 L/min Deionization life (standard ) N/A N/A 1 m 3 Deionization life (high capacity ) N/A 3 m 3 3 m 3 (optional) Recovery >30 % >30 % >30 % Dimensions (WxDxH), cm 40x35x55 40x50x55 40x35x55 (option) 25 L 300 L 25 L 300 L 25 L 300 L 25L dimensions (WxDxH), cm 30x25x50 30x25x50 30x25x50 Feed water pressure 0.5 5 bar 0.5 5 bar 0.5 5 bar Feed water conductivity < 900 μs/cm < 900 μs/cm < 900 μs/cm 15

diagrams (RO ) Check Pure (Grade 2) water RO (RO ) Deionization Check Pure (Grade 2) water Pure (RO ) Deionization Check Pure (Grade 2) water 20 Pure 16

Applications Application Crystal E RO Crystal E Pure Glassware rinsing Laboratory washers Autoclaves Electrochemistry Flame AAS Wet chemistry Spectrophotometry Buffer and media preparation Components Accessory 10009 Pre- for chlorine and organics reduction 10039 Pre- set for chlorine and organics reduction RO Crystal E20 Pure Crystal Pure E + - + - + - + + + + + + 10310 Deionization, standard + 10101 High capacity deionization, (replaces standard ) + option 10201 Point-of-use microfiltration for Pure systems option option 10102 UV sterilization option option s Accessory RO Crystal E20 Pure Pure 11000 Basic w/, 25L option option option 10007 Comfort w/, 60L option option option 10004 Economy w/, 50L option option option 11014 Tiny, 10L option option option 10027 Comfort w/, 100L option option option Ordering Information Model Pure CE-1005 10026 Comfort w/, 200L option option option 10025 Comfort w/, 300L option option option RO 20 Pure CE-1245 C20-1001HC Consumables 10009 Description Replacement criteria Comments Replacement, RO, Pure Filter life counter is zero or the is clogged 10039 Replacement set, 20 Pure Filter life counter is zero or the is clogged 10310 Replacement deionization DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm Pure systems only 10113 Replacement high-capacity deionization DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm Only E20 Pure or systems with 10101 option 10011 Replacement sterilization UV bulb As required (on average every 3 years) Only systems with 10102 option 10012 Replacement 0.22 μm Every 6 12 months Only systems with 10201 option 17

systems Crystal 7 RO and Pure series The Crystal 7 Pure system (P/N C7-1001) is an entry level water purification system with very low system running costs. It is wall-mounted and does not require any space on a laboratory bench. The Crystal 7 Pure system produces purified water for general laboratory applications and analytical methods. Crystal 7 system water is used for many applications, including: Many inorganic methods of analysis (e. g. flame spectrophotometry) Wet chemistry methods Electrochemistry Labware washing, etc. The Crystal 7 Pure system is a reliable source of purified lab water with conductivity < 0.1 μs/cm (resistivity > 10 MegaOhm*cm). This exceeds requirements for Grade 2 water according to ISO 3696. The operating costs of a Crystal 7 Pure system are extremely low. The Crystal 7 RO system (P/N C7-1241) produces water that complies with ISO 3696 Grade 3 requirements. Specifications The Crystal 7 Pure and RO systems are equipped with a graphic LCD display providing system status info and water monitoring readouts. The remaining life and deionization (DI) performance are shown on the LCD display. The smart DI monitoring system provides a reduction in system operating costs. Users are instructed to replace the DI only when the is near the end of its service life. s for purified water are an available option. We offer storage s ranging in capacity from 10L 60L. Tanks of 25L or more have integrated s for fast and convenient dispensing. The dispensing flow rate is 4 L/min. All cartridges and s are easy to access and replace. An integrated allows users to place the storage under a bench, if desired, to save space. The Crystal 7 system has important safety functions, including: filling control tap water pressure control protection from failure The Crystal 7 systems include: boost set reverse deionization A UV-sterilization is available as an option (P/N 10102). Ordering Information Model Crystal 7 Pure C7-1001 Crystal 7 RO C7-1241 Purified water specifications Crystal 7 RO Crystal 7 Pure Purified water resistivity >10 MΩ x cm Purified water conductivity <5 μs/cm <0.1 μs/cm icles > 0.22 μm <1 per ml <1 per ml Nominal flow, pure water (to storage ) 7 L/h 7 L/h Dispense flow, pure water 4 L/min 4 L/min Deionization life N/A 1 m 3 Recovery >30 % >30 % Dimensions (WxDxH), cm 50x20x52 50x20x52 (option) 10 L 60 L 10 L 60 L Feed water pressure 0.5 5 bar 0.5 5 bar Feed water conductivity < 900 μs/cm < 900 μs/cm s Accessory Crystal 7 RO Crystal 7 Pure 11000 Basic w/, 25L option option 10007 Comfort w/, 60L option option 10004 Economy w/, 50L option option 11014 Tiny, 10L option option 18

diagrams Crystal 7 RO (RO ) Check 1μm sediment Pure (Grade 2) water Crystal 7 Pure (RO ) Check Deionization 1μm sediment Pure (Grade 2) water Applications Application Crystal 7 RO Crystal 7 Pure Glassware rinsing Laboratory washers Autoclaves Electrochemistry Flame AAS Wet chemistry Spectrophotometry Buffer and media preparation Components Accessory Crystal 7 RO 10014 Pre- set for chlorine and organics reduction Crystal 7 Pure + + + + + + 10015 Deionization pack + 10102 UV sterilization option Consumables 10014 10015 10011 Description Replacement criteria Comments Replacement set, Crystal 7 Replacement deionization Replacement sterilization UV bulb Filter life counter is zero or the is clogged DI Err message is shown, or water conductivity is consistently > 0.5 μs/cm As required (on average every 3 years) Systems with 10102 option only 19

systems Sterifeed Sterifeed is a water purification system that is designed to produce feed water for autoclaves. The Sterifeed system produces water with conductivity of 5-11 us/cm. This is within the recommended conductivity range of 3-15 us/cm, presented by autoclave manufacturers. Specifications Water with a conductivity reading above 15 us/cm facilitates salt deposits on heating elements, eventually leading to the failure of the heating element. Water with a conductivity below 3 us/cm can attack internal surfaces of the autoclave, thusly damaging water level s, heating elements, and connections. Sterifeed water provides optimal conductivity, within the range of 5-11 us/cm, granting reliable operation of the autoclave. A pressurized water storage provides a consistent water supply to the autoclave. Many autoclaves require a pressurized and purified water supply. Some autoclaves have priming s for purified water intake, but if the water supply is not pressurized, an air gap may block the water flow. If an air blockage occurs, the operation of autoclave is not possible until the air is removed from the system. The pressurized water storage of the Sterifeed system eliminates the formation of air gaps, and ensures reliable operation of the autoclave. The Sterifeed system has an LCD display that provides information about the system status, water, and the remaining life. The water softening ensures long life of the purifying elements. These design features reduce the operational costs for your laboratory. Purified water specifications Sterifeed Purified water resistivity Purified water conductivity 5-11 μs/cm icles > 0.22 μm <1 per ml Nominal flow, pure water (to storage ) 10 L/h Deionization life N/A Recovery >30 % Dimensions (WxDxH), cm 50x20x52 Pressurized storage 60 L Tanks dimensions, cm 42x42x60 Feed water pressure 0.5 5 bar Feed water conductivity < 900 μs/cm The Sterifeed comes with the necessary accessories for connection to an autoclave, and no tools are required! 20

diagram (RO ) 5 μm sediment 1 μm sediment Check To autoclave Pressurized storage Softening cartridge Carbon cartridge Consumables Description Replacement criteria Comments 10016 Replacement set, Sterifeed Filter life counter is zero or the is clogged Ordering Information Model Crystal Sterifeed CS-1002 21

systems Crystal Clinic The Crystal Clinic water purification system is designed to provide purified water to automated biochemistry analyzers. Purified water ensures long-term, reliable operation from a biochemistry analyzer. Water produced from the Crystal Clinic has a resistivity of 10 MegaOhm*cm. This exceeds the manufacturers requirements for feed water to biochemistry analyzers. A double RO and pressurized 60L ensure a stable and reliable supply of water. The Crystal Clinic systems are equipped with a pressure regulator. Purified water pressure is precisely adjusted to the requirements of the analyzer. The Crystal Clinic has two reverse s and a high-capacity deionization cartridge (DI). The large DI cartridge volume significantly reduces operating costs. Water purified by the reverse s is collected in the storage.the water is then polished to 10 MegaOhm*cm by the deionization. The two reverse s enable a high flow rate through the permeable membranes, ensuring that purified water is always available. Pictures are for reference only. Depending on configuration, some options may not be present Specifications Purified water specifications Clinic Grade 2 water resistivity >10 MΩ x cm Grade 2 water conductivity <0.1 μs/cm icles > 0.22 μm <1 per ml Nominal flow, pure water (to storage ) 28 L/h Dispense flow to analyzer 4 L/min Dispense pressure 100 kpa Deionization life (high capacity ) 3 m 3 Recovery >30 % Dimensions (WxDxH), cm 40x50x55 Pressurized storage 60 L Tank dimensions, cm 42x42x60 Feed water pressure 0.5 5 bar Feed water conductivity < 900 μs/cm A large LCD display provides information about the system status, water, and life. The Crystal Clinic has two water s. The first controls the of water filling the storage. This is shown on the LCD display while the is beeing filled. The second controls the of water supplied to the Biochemical Analyzer. The Crystal Clinic system automatically monitors the performance of the deionization and alerts the operator when the DI needs replacement. The DI and can be replaced by the operator. No tools required! The Crystal Clinic has a port on the front panel. Pure (Grade 2) water can be used for general laboratory applications. 22

diagram (RO ) Check regulator Deionization Pressurized storage To analyzer Final pointof-use Components Accessory Crystal Clinic 10039 Pre- set for chlorine and organics reduction + Ordering Information s + s + 10101 High capacity deionization + 10102 UV sterilization option Model Crystal Clinic CL-2810 Consumables 10039 Description Replacement criteria Comments Replacement set, Crystal Clinic Filter life counter is zero or the is clogged 10113 Replacement high-capacity deionization DI Err message is shown, or water conductivity > 0.1 μs/cm 10011 Replacement sterilization UV bulb As required (on average every 3 years) Only for systems equipped with 10102

Dzerbenes 27, Riga LATVIA, LV 1006 Tel.: +371 67551894, +371 67551993 Fax: +371 67551976 e-mail: info@adrona.lv www.adrona.lv