SAFETY DATA SHEET. SECTION 1: Identification of the substance/mixture and of the company/ undertaking. SECTION 2: Hazards identification



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SAFETY DATA SHEET, Part Number 600198 SECTION 1 Identification of the substance/mixture and of the company/ undertaking 1.1 Product identifier Product name Part No. (Kit) 600198 Part No., Part Number 600198 10X Taq 600197-51 600131-82 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses Analytical reagent. 10X Taq 1 ml 20 ml 1.3 Details of the supplier of the safety data sheet Agilent Technologies Manufacturing GmbH & Co. KG Hewlett-Packard-Str. 8 76337 Waldbronn Germany 0800 603 1000 e-mail address of person responsible for this SDS pdl-msds_author@agilent.com 1.4 Emergency telephone number Emergency telephone number (with hours of operation) CHEMTREC +(44)-870-8200418 SECTION 2 Hazards identification 2.1 Classification of the substance or mixture Product definition Mixture 10X Taq Mixture Classification according to Regulation (EC) No. 1272/2008 [CLP/GHS] H412 LONG-TERM AQUATIC HAZARD - Category 3 10X Taq H412 LONG-TERM AQUATIC HAZARD - Category 3 Ingredients of unknown toxicity Ingredients of unknown ecotoxicity Classification according to Directive 1999/45/EC [DPD] 10X Taq Percentage of the mixture consisting of ingredient(s) of unknown toxicity 1.6% Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment 50% 10X Taq Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment 1.6% 08/12/2014 1/16

, Part Number 600198 SECTION 2 Hazards identification The product is not classified as dangerous according to Directive 1999/45/EC and its amendments. 10X Taq The product is not classified as dangerous according to Directive 1999/45/EC and its amendments. Classification Not classified. 10X Taq Not classified. See Section 16 for the full text of the R phrases or H statements declared above. See Section 11 for more detailed information on health effects and symptoms. 2.2 Label elements Signal word Hazard statements Precautionary statements 10X Taq 10X Taq Prevention 10X Taq Response 10X Taq Storage 10X Taq Disposal 10X Taq Hazardous ingredients No hazardous ingredient Supplemental label elements Annex XVII - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles Special packaging requirements Tactile warning of danger 10X Taq 10X Taq No signal word. No signal word. Harmful to aquatic life with long lasting effects. Harmful to aquatic life with long lasting effects. P273 - Avoid release to the environment. P273 - Avoid release to the environment. P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. 2.3 Other hazards Other hazards which do not result in classification 10X Taq None known. None known. 08/12/2014 2/16

, Part Number 600198 SECTION 3 Composition/information on ingredients 3.2 Mixtures Mixture 10X Taq Mixture Product/ingredient name Identifiers Classification % 67/548/EEC Regulation (EC) No. Type 1272/2008 [CLP] CAS 9036-19-5 <1 Xi; R41 Eye Dam. 1, H318 Aquatic Acute 1, H400 Aquatic Chronic 1, H410 [1] [5] 10X Taq Potassium chloride EC 231-211-8 CAS 7447-40-7 Poly(oxy-1, 2-ethanediyl),.alpha.-[ (1,1,3, 3-tetramethylbutyl) phenyl]-.omega.- hydroxy- 2-Amino-2- (hydroxymethyl) propane-1,3-diol hydrochloride EC 214-684-5 CAS 1185-53-1 >=1 - <5 >=1 - <5 Not classified. Aquatic Chronic 2, H411 [1] Xi; R36/37/38 See Section 16 for the full text of the R- phrases declared above. Skin Irrit. 2, H315 Eye Irrit. 2, H319 STOT SE 3, H335 (Respiratory tract irritation) See Section 16 for the full text of the H statements declared above. [1] There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Type [1] Substance classified with a health or environmental hazard [2] Substance with a workplace exposure limit [3] Substance meets the criteria for PBT according to Regulation (EC) No. 1907/2006, Annex XIII [4] Substance meets the criteria for vpvb according to Regulation (EC) No. 1907/2006, Annex XIII [5] Substance of equivalent concern Occupational exposure limits, if available, are listed in Section 8. SECTION 4 First aid measures 4.1 Description of first aid measures Eye contact Inhalation 10X Taq 10X Taq Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. 08/12/2014 3/16

, Part Number 600198 SECTION 4 First aid measures Skin contact Ingestion Protection of first-aiders 10X Taq 10X Taq 10X Taq Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. No action shall be taken involving any personal risk or without suitable training. No action shall be taken involving any personal risk or without suitable training. 4.2 Most important symptoms and effects, both acute and delayed Potential acute health effects Eye contact Inhalation Skin contact Ingestion Over-exposure signs/symptoms Eye contact Inhalation Skin contact Ingestion 10X Taq 10X Taq Exposure to decomposition products may cause a health hazard. Serious effects may be delayed following exposure. 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 4.3 Indication of any immediate medical attention and special treatment needed 08/12/2014 4/16

, Part Number 600198 SECTION 4 First aid measures Notes to physician Specific treatments 10X Taq 10X Taq SECTION 5 Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. No specific treatment. No specific treatment. Use an extinguishing agent suitable for the surrounding fire. Unsuitable extinguishing media 10X Taq None known. None known. 5.2 Special hazards arising from the substance or mixture Hazards from the substance or mixture Hazardous combustion products 10X Taq 10X Taq In a fire or if heated, a pressure increase will occur and the container may burst. This material is harmful to aquatic life with long lasting effects. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain. In a fire or if heated, a pressure increase will occur and the container may burst. This material is harmful to aquatic life with long lasting effects. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain. Decomposition products may include the following materials carbon dioxide carbon monoxide Decomposition products may include the following materials carbon dioxide carbon monoxide nitrogen oxides halogenated compounds metal oxide/oxides 5.3 Advice for firefighters Special precautions for fire-fighters Special protective equipment for firefighters 10X Taq 10X Taq Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves) conforming to European standard EN 469 will provide a basic level of protection for chemical incidents. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves) conforming to European standard EN 469 will provide a basic level of protection for chemical incidents. 08/12/2014 5/16

, Part Number 600198 SECTION 6 Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures For non-emergency personnel For emergency responders 10X Taq 10X Taq No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For nonemergency personnel". If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For nonemergency personnel". 6.2 Environmental precautions 10X Taq Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). 6.3 Methods and material for containment and cleaning up Methods for cleaning up 6.4 Reference to other sections SECTION 7 Handling and storage 7.1 Precautions for safe handling Protective measures Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. See Section 1 for emergency contact information. See Section 8 for information on appropriate personal protective equipment. See Section 13 for additional waste treatment information. 10X Taq Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Avoid release to the environment. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Avoid release to the environment. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. 08/12/2014 6/16

, Part Number 600198 SECTION 7 Handling and storage Advice on general occupational hygiene 10X Taq Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. 7.2 Conditions for safe storage, including any incompatibilities 10X Taq Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. 7.3 Specific end use(s) Recommendations Industrial sector specific solutions 10X Taq SECTION 8 Exposure controls/personal protection 8.1 Control parameters Occupational exposure limits No exposure limit value known. Recommended monitoring procedures DNELs/DMELs No DNELs available. PNECs No PNECs available. Industrial applications, Professional applications. Industrial applications, Professional applications. If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to monitoring standards, such as the following European Standard EN 689 (Workplace atmospheres - Guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy) European Standard EN 14042 (Workplace atmospheres - Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents) European Standard EN 482 (Workplace atmospheres - General requirements for the performance of procedures for the measurement of chemical agents) Reference to national guidance documents for methods for the determination of hazardous substances will also be required. 08/12/2014 7/16

, Part Number 600198 SECTION 8 Exposure controls/personal protection 8.2 Exposure controls Appropriate engineering controls Individual protection measures Hygiene measures Eye/face protection Skin protection Hand protection Body protection Other skin protection Respiratory protection Environmental exposure controls Good general ventilation should be sufficient to control worker exposure to airborne contaminants. Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection safety glasses with sideshields. Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are still retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for different glove manufacturers. In the case of mixtures, consisting of several substances, the protection time of the gloves cannot be accurately estimated. Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. SECTION 9 Physical and chemical properties 9.1 Information on basic physical and chemical properties Appearance Physical state Colour Odour Odour threshold 10X Taq 10X Taq 10X Taq 10X Taq Liquid. Liquid. 08/12/2014 8/16

, Part Number 600198 SECTION 9 Physical and chemical properties ph Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Flammability (solid, gas) Upper/lower flammability or explosive limits Vapour pressure Vapour density Relative density Solubility(ies) Partition coefficient n- octanol/water Auto-ignition temperature Decomposition temperature Viscosity 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 10X Taq 8 8.8 Easily soluble in the following materials cold water and hot water. Easily soluble in the following materials cold water and hot water. 08/12/2014 9/16

, Part Number 600198 SECTION 9 Physical and chemical properties Explosive properties 10X Taq 9.2 Other information No additional information. SECTION 10 Stability and reactivity 10.1 Reactivity 10X Taq No specific test data related to reactivity available for this product or its ingredients. No specific test data related to reactivity available for this product or its ingredients. 10.2 Chemical stability 10X Taq The product is stable. The product is stable. 10.3 Possibility of hazardous reactions 10X Taq Under normal conditions of storage and use, hazardous reactions will not occur. Under normal conditions of storage and use, hazardous reactions will not occur. 10.4 Conditions to avoid 10.5 Incompatible materials 10.6 Hazardous decomposition products 10X Taq SECTION 11 Toxicological information 11.1 Information on toxicological effects Acute toxicity Poly(oxy-1,2-ethanediyl),. alpha.-[(1,1,3, 3-tetramethylbutyl)phenyl]-. omega.-hydroxy- Under normal conditions of storage and use, hazardous decomposition products should not be produced. Under normal conditions of storage and use, hazardous decomposition products should not be produced. Product/ingredient name Result Species Dose Exposure LD50 Oral Rat 2800 mg/kg - 10X Taq Potassium chloride LD50 Oral Rat 2600 mg/kg - Acute toxicity estimates Irritation/Corrosion 08/12/2014 10/16

, Part Number 600198 SECTION 11 Toxicological information Product/ingredient name Result Species Score Exposure Observation Poly(oxy-1,2-ethanediyl),. alpha.-[(1,1,3, 3-tetramethylbutyl)phenyl]-. omega.-hydroxy- Potential acute health effects Inhalation Ingestion Skin contact Eye contact 10X Taq 10X Taq 10X Taq Exposure to decomposition products may cause a health hazard. Serious effects may be delayed following exposure. Symptoms related to the physical, chemical and toxicological characteristics Inhalation Ingestion Skin contact Eyes - Severe irritant Rabbit - 1 Percent - 10X Taq Potassium chloride Eyes - Mild irritant Rabbit - 24 hours 500 milligrams Sensitiser Conclusion/Summary Chronic toxicity / Carcinogenicity / Mutagenicity / Teratogenicity / Reproductive toxicity Specific target organ toxicity (single exposure) Specific target organ toxicity (repeated exposure) Aspiration hazard Information on the likely routes of exposure Product/ingredient name 10X Taq 10X Taq 10X Taq 10X Taq Category Route of exposure - Target organs 10X Taq 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride Category 3 Respiratory tract irritation 08/12/2014 11/16

, Part Number 600198 SECTION 11 Toxicological information Eye contact Potential chronic health effects General 10X Taq Carcinogenicity 10X Taq Mutagenicity 10X Taq Teratogenicity 10X Taq Developmental effects Fertility effects 10X Taq 10X Taq 10X Taq Delayed and immediate effects and also chronic effects from short and long term exposure Short term exposure Potential immediate effects Potential delayed effects Long term exposure Potential immediate effects Potential delayed effects Toxicokinetics Absorption Distribution Metabolism Elimination 10X Taq 10X Taq 10X Taq 10X Taq 08/12/2014 12/16

, Part Number 600198 SECTION 11 Toxicological information Other information 10X Taq SECTION 12 Ecological information 12.1 Toxicity Product/ingredient name Poly(oxy-1,2-ethanediyl),. alpha.-[(1,1,3, 3-tetramethylbutyl)phenyl]-. omega.-hydroxy- Result Acute EC50 210 μg/l Fresh water Species Algae - Pseudokirchneriella subcapitata Exposure 96 hours Acute LC50 10800 μg/l Marine water Crustaceans - Pandalus 48 hours montagui - Adult Acute LC50 8600 to 9800 μg/l Fresh Daphnia - Daphnia magna - 48 hours water Neonate Acute LC50 7200 μg/l Fresh water Fish - Oncorhynchus mykiss 96 hours 10X Taq Potassium chloride Acute EC50 1337000 μg/l Fresh water Algae - Navicula seminulum 96 hours Acute EC50 9.24 g/l Fresh water Algae - Desmodesmus 72 hours subspicatus Acute EC50 83000 μg/l Fresh water Daphnia - Daphnia magna 48 hours Acute LC50 9.68 mg/l Fresh water Crustaceans - Pseudosida 48 hours ramosa - Neonate Acute LC50 880000 μg/l Fresh water Fish - Pimephales promelas 96 hours 12.2 Persistence and degradability Conclusion/Summary 12.3 Bioaccumulative potential 12.4 Mobility in soil Soil/water partition coefficient (KOC) Mobility 12.5 Results of PBT and vpvb assessment PBT vpvb 12.6 Other adverse effects SECTION 13 Disposal considerations 13.1 Waste treatment methods Product Methods of disposal The generation of waste should be avoided or minimised wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction. Hazardous waste The classification of the product may meet the criteria for a hazardous waste. Packaging 08/12/2014 13/16

, Part Number 600198 SECTION 13 Disposal considerations Methods of disposal Special precautions SECTION 14 Transport information Regulatory information ADR/RID / IMDG / IATA The generation of waste should be avoided or minimised wherever possible. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Care should be taken when handling emptied containers that have not been cleaned or rinsed out. Empty containers or liners may retain some product residues. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Not regulated. 14.6 Special precautions for user Transport within user s premises always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage. 14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code Annex XVII - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles Other EU regulations Europe inventory SECTION 15 Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture EU Regulation (EC) No. 1907/2006 (REACH) Annex XIV - List of substances subject to authorisation Annex XIV None of the components are listed. Substances of very high concern Ingredient name 4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated [covering well-defined substances and UVCB substances, polymers and homologues] Seveso II Directive Intrinsic property Status Reference Date of number Substance of equivalent concern for environment At least one component is not listed. This product is not controlled under the Seveso II Directive. International regulations Chemical Weapon Convention List Schedules I, II & III Chemicals Not listed. Montreal Protocol (Annexes A, B, C, E) Not listed. Stockholm Convention on Persistent Organic Pollutants Not listed. Rotterdam Convention on Prior Inform Consent (PIC) Recommended ED/169/2012 6/11/2013 08/12/2014 14/16

, Part Number 600198 SECTION 15 Regulatory information Not listed. UNECE Aarhus Protocol on POPs and Heavy Metals Not listed. International lists National inventory Australia Canada China Japan Malaysia New Zealand Philippines Republic of Korea Taiwan United States All components are listed or exempted. All components are listed or exempted. All components are listed or exempted. Not determined. Not determined. All components are listed or exempted. All components are listed or exempted. Not determined. Not determined. All components are listed or exempted. 15.2 Chemical Safety Assessment SECTION 16 Other information This product contains substances for which Chemical Safety Assessments are still required. Indicates information that has changed from previously issued version. Abbreviations and acronyms ATE = Acute Toxicity Estimate CLP = Classification, Labelling and Packaging Regulation [Regulation (EC) No. 1272/2008] DNEL = Derived No Effect Level EUH statement = CLP-specific Hazard statement PNEC = Predicted No Effect Concentration RRN = REACH Registration Number Procedure used to derive the classification according to Regulation (EC) No. 1272/2008 [CLP/GHS] Aquatic Chronic 3, H412 Classification Calculation method Justification 10X Taq Aquatic Chronic 3, H412 Full text of abbreviated H statements H318 H400 H410 H412 10X Taq H315 H319 H335 (Respiratory tract irritation) H411 H412 Calculation method Causes serious eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects. Harmful to aquatic life with long lasting effects. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. (Respiratory tract irritation) Toxic to aquatic life with long lasting effects. Harmful to aquatic life with long lasting effects. 08/12/2014 15/16

, Part Number 600198 SECTION 16 Other information Full text of classifications [CLP/GHS] Aquatic Acute 1, H400 ACUTE AQUATIC HAZARD - Category 1 Aquatic Chronic 1, H410 LONG-TERM AQUATIC HAZARD - Category 1 Aquatic Chronic 3, H412 LONG-TERM AQUATIC HAZARD - Category 3 Eye Dam. 1, H318 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 1 Full text of abbreviated R phrases Full text of classifications [DSD/DPD] Date of issue/ Date of Date of previous issue Version 10X Taq Aquatic Chronic 2, H411 LONG-TERM AQUATIC HAZARD - Category 2 Aquatic Chronic 3, H412 LONG-TERM AQUATIC HAZARD - Category 3 Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2 Skin Irrit. 2, H315 SKIN CORROSION/IRRITATION - Category 2 STOT SE 3, H335 (Respiratory tract irritation) 10X Taq 10X Taq 08/12/2014 15/11/2012. 3 SPECIFIC TARGET ORGAN TOXICITY (SINGLE EXPOSURE) (Respiratory tract irritation) - Category 3 R41- Risk of serious damage to eyes. R36/37/38- Irritating to eyes, respiratory system and skin. Xi - Irritant Xi - Irritant Notice to reader Disclaimer The information contained in this document is based on Agilent s state of knowledge at the time of preparation. No warranty as to its accurateness, completeness or suitability for a particular purpose is expressed or implied. 08/12/2014 16/16