CURRICULUM VITAE DAVID R. HOLMES JR., M.D.

CURRICULUM VITAE DAVID R. HOLMES JR., M.D. PERSONAL DATA: Name: Birthdate/place: Citizenship: Spouse: Children: David R. Holmes Jr., M.D. November 21, 1945; Oak Park, IL USA Virginia Zuehlke David; Joshua; Nathaniel; Jessica Professional Address: Mayo Clinic Saint Marys Hospital, MB4-523 200 First Street SW Rochester, MN 55905 Phone: (507) 255-2504 Fax: (507) 255-2550 PRESENT ACADEMIC RANK AND POSITION: Consultant, Division of Cardiovascular Diseases & Internal Medicine, Department of Internal Medicine Mayo Clinic, Rochester, Minnesota July 1978 to present Professor of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota July 1, 1987 to present Master s Faculty Privileges in Clinical Research Mayo Graduate School of Medicine, Mayo Foundation for Medical Education and Research, Rochester, Minnesota 2003 to present PREVIOUS PROFESSIONAL POSITIONS AND MAJOR APPOINTMENTS Instructor of Medicine Mayo Clinic College of Medicine, Rochester, Minnesota, 1976-1979 Assistant Professor of Medicine Mayo Clinic College of Medicine, Rochester, Minnesota, 1979-1983 Associate Professor of Medicine Mayo Clinic College of Medicine, Rochester, Minnesota, 1983-1987 Director - Electrophysiology and Pacing, Mayo Clinic and Mayo Foundation, 1981 to 1985 Director - Cardiac Catheterization Laboratory, Division of Cardiovascular Diseases & Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, 1984-2003 EDUCATION:

Curriculum Vitae -2- College/University: Medical School: Internship: Princeton University, Princeton, NJ; 1963-1967 (B.A.) Medical College of WI, Milwaukee, WI; 1967-1971 (M.D.) Virginia Mason Hospital, Seattle, WA; 1971-1972 (Straight Internship) Fellowship: Internal Medicine, Mayo Clinic, Rochester, MN; 1972-1974 Cardiovascular Diseases, Mayo Clinic, Rochester, MN; 1974-1976 BOARD CERTIFICATION(S): American Board of Internal Medicine June 1974; #047067 Subspecialty, Cardiovascular Disease October 1977; #047067 MEDICAL LICENSURE (S): 1972 present State of Minnesota #20568 2000 present State of Wisconsin #42029-020 2005 present State of Arizona #34891 2010 present State of Florida #ME 106767 HONORS / AWARDS: 1971 Alpha Omega Alpha Honor Society 1972 Outstanding Intern Award; Virginia Mason Hospital 1974 Internal Medicine Achievement Award, Mayo Graduate School 1992-2010 Best Doctors in America 1995 Transcatheter Therapeutics Career Achievement Award; Washington Cardiology Center 2000 Paul Dudley White Visiting Professor in Cardiovascular Medicine 2003 9 th Annual Robert L. Frye Lectureship at Mayo Clinic 2003 Mayo Clinic Cardiovascular Division Teacher of the Year 2003 Edward W. and Betty Knight Scripps Professor in Cardiovascular Medicine 2002-2003 President elect, Minnesota Chapter ACC 2004 Member, Board of Trustees ACC HONORS / AWARDS (cont.):

Curriculum Vitae -3-2004 Mayo Foundation Research Career Achievement Award 2006 American Heart Association Affiliate Eugene Drake Award 2006 ACC Distinguished Scientist Award (Clinical Domain) 2006 Champion of MN Cardiology Awardee, MN ACC chapter 2007 James B. Herrick Award of the American Heart Association Council on Clinical Cardiology 2008 Masters Faculty Privileges in Clinical Research 2010 Carl Wiggers Award 2011 Honorary Fellowship of the Royal College of Physicians of Ireland (FRCPI) 2012 Master of the American College of Cardiology (MACC) 2012 Fellow of the European Society of Cardiology (FESC) 2012 Medical College of Wisconsin Alumnus of the Year 2013 FDA Leveraging/Collaboration Award, TVT Registry Team MILITARY SERVICE: 1976-1978 United States Navy, National Naval Medical Center; Bethesda, MD Captain, (Retired-- 7-1-04) United States Naval Reserve Officer in Charge, Mayo PRIMUS Unit PROFESSIONAL & COMMUNITY MEMBERSHIPS, SOCIETIES, AND SERVICES: Professional Memberships & Services Alpha Omega Alpha 1971 American Board of Internal Medicine Invasive Cardiology Certification Examination Writing Committee 1996 2011 Interventional Cardiology Test Committee (through 2005) Committee for Maintenance of Certification 2006-2007 American College of Cardiology Immediate Past President, American College of Cardiology (2012) President, American College of Cardiology (2011-2012) Vice-President, American College of Cardiology (2009-2010) Fellow, American College of Cardiology Board of Trustees member (2004) Governor-elect, Minnesota Chapter ACC (2002-2003) Governor, Minnesota Chapter ACC (2003-2004) Co-chairman, Inaugural ACC Interventional Symposium (ACCIS) (1999, 2000) Co-chairman, ACC Annual Meeting 2003 Co-chairman, Annual Scientific Sessions 2003 Chairman, Procedure Training Working Group (1999-present) Chairman, ACC FAME initiative (2000-present) Interventional Spotlight Planning Committee (2001-2002)

Curriculum Vitae -4- PROFESSIONAL MEMBERSHIPS AND SOCIETIES (cont): American College of Cardiology (cont.) Strategic Education Directions Committee (2001-present) Educational Program Committee (1999-2001) Learning Center Committee (1997-2000) Sub-committee for Written Standards for Interventional Cardiology (1997-2000) Co-Director, Heart House Interventional Cardiology Course (1995-present) Co-Director, Cardiology at Big Sky 1995 - present Co-Director, Yellowstone Summit 1996-2002 Abstract Grader, Annual Scientific Sessions (1985-present) Co-author, Expert Consensus Stent Document (1996, 1998) International Speakers Bureau Member, DICOM Committee International Governance Council (2009-2010) Interventional Scientific Council (2007-2011) Executive Committee Member (2009-2013) Executive Committee Chair (2011-2012) American Heart Association Fellow (FAHA) Abstract Grader (1985-present) Session Moderator (1985-present) Circulation Council 1987-present Interventional Andreas Gruentzig Society Inaugural Member Program Chair, 2000 Minnesota Society of Internal Medicine New England Institute of Advanced Medical Simulation, Board of Directors Franciscan Skemp Healthcare (FSH) Board member 2004-2005 Japanese College of Cardiology International Advisory Board Member 2013 National Institutes of Health Balloon Valvuloplasty Registry Steering Committee PTCA Registry Steering Committee, 1985-present Thrombolysis in Myocardial Infarction Angiography Subcommittee, 1986-present Sigma Xi, The Scientific Research Society Society for Cardiac Angiography and Interventions Fellow

1996 President 1994-1995 Secretary Training Standards Committee, Chair 1990-1994 Interventional Committee, 1997-1998 Continuing Medical Education Committee, 1997- present Interventional Cardiology Committee, 1992 - present Industry Round Table Committee, 1998 - present Laboratory Standards, 1990-1995 Government Relations, 1995-1997 Industry Relations Committee 1997-1998 Interventional Scientific Council 2007-2009 David R. Holmes Jr., M.D. Curriculum Vitae -5- New York State Advisory Board NY State Department of Health, Cardiac Advisory Committee - 2000 to 2013 Cardiac Catheterization Committee, SCAI Representative, 1994-1997 Ad Hoc Committee on Health System Reform, SCAI Representative, 1995-1995 Cardiovascular Subspecialty Societies Leadership Group, SCAI Representative, 1995-1996 Educational Products Subcommittees, Cardiac Catheterization and Interventional Cardiology, Self Assessment Program (Cath-SAP), 1996-1997 Ad Hoc Writing Committee on Competence in Interventional Cardiology, 1997-1999 NY State Department of Health, Elective PCI in Non-Surgery Centers, Workgroup Chair 2004-2005 Adult Electrophysiology Workgroup (chair) Certificate of Need (CON) Consultants Executive Committee PCIRS Subcommittee Planning and Policy Subcommittee Quality Improvement Workgroup NY State Cardiac Advisory Committee (through 9-30-2010) Heart Valve Society of America (HVSA) Founding member 2004 Editorial Reviewer ASEAN Heart Journal-Editorial Consultant European Heart Journal Circulation EuroIntervention Journal American Journal of Cardiology Journal of American College of Cardiology Chest Journal of Thoracic and Cardiovascular Surgery Mayo Clinic Proceedings Catheterization and Cardiovascular Diagnosis New England Journal of Medicine Journal of Invasive Cardiology Journal of Cardiovascular Translational Research

Curriculum Vitae -6- Editorial Board Member American Heart Journal The American Heart Hospital Journal The American Journal of Cardiology Journal of the American College of Cardiology Catheterization and Cardiovascular Diagnosis ACCEL Editorial Board International Advisory Board - Journal of Cardiology Cardio Vascular Radiation Medicine Circulation Current Cardiology Reviews Journal of Cardiovascular Risk Catheterization and Cardiovascular Interventions International Journal of Cardiovascular Interventions Minerva Medica Today in Cardiology (2004) Acute Cardiac Care (2006-2007) International Advisory Board Journal of Cardiology (2007) Saudi Heart Journal Interventional Cardiology (2009) Editorial Advisory Board of the Cardiology Coding Advisor (2013) International Advisory Board of the Journal of Cardiology Trends in Cardiovascular Medicine Editor Current Interventional Cardiology reports-editor (1999-2001) Reviews in Cardiovascular Medicine-Section Editor (1999-2004) Current Controlled Trials in Cardiovascular Medicine--Associate Editor Seminars in Interventional Cardiology International Journal of Cardiology (1995-1999) Interventional Cardiology Newsletter (1993-1996) JACC Interventions - Associate Editor (2009-present) JACC - Associate Editor (2014-2015) EDUCATIONAL ACTIVITIES: Mayo Clinic, Rochester, MN Undergraduate Mayo Medical School II; Sessions: Arrhythmias, Pathophysiology and Antiarrhythmic Agents (1983 to present) Student Supervision, Hospital Services Postgraduate Cardiovascular Training Program; 2-4 presentations/year (1979 to present) Cardiovascular Board Reviews, alternate years Resident Teaching, Hospital Services (1978 to present) Supervision and Training, Cardiology Fellows, in Pacing and Electrophysiology

Curriculum Vitae -7- (1981 to present) Supervision and Training, Cardiology Fellows, in Invasive Cardiology Practice (1981 to present) Mayo Alumni Association Course Director Interventional Cardiology Course Heart House (1996 to present) Co-Director Cardiology at Big Sky (1995 to present) Co-Director Yellowstone Summit (1996) Co-Director Practice of Interventional Cardiology Course Heart House (1995) Co-Director Mayo Clinic Cardiology Board Review Course (1996, 1997) Clinical Reviews Mayo Clinic Update in Cardiology (1990 to present) American College of Cardiology, Session Moderator (1985 to present) American Heart Association, Session Moderator (1985 to present) Master s Faculty Privileges in Clinical Research Carotid angioplasty/stenting/angiography clinical privileges (Feb. 2005 to present) RESEARCH ACTIVITIES NIH Sponsored Balloon Valvuloplasty Registry Steering Committee PTCA Registry Steering Committee (1985 to present) Thrombolysis in Myocardial Infarction Angiography Subcommittee (1986 to present) BARI Study Co-investigator Dynamic WAVE Registry (March 11, 1997 to present) NACI Registry (January 1991 through April 1998) Endothelin in Humans Coronary in Early Atherosclerosis-Consultant Industry Sponsored GUSTO I, II CAVEAT 1, 2 BOAT Trial RAVES Trial SABER Trial SMART Trial ATLAS Trial PRESTO Trial SIRIUS Bifurcation Distal Protection MedNova Bioheart X-Tract SCORES + 5 SAFER COURAGE REPLACE 2 CREST Logic Panacea COOL MI Berlex Factor Xa Inhibitor Regional Coordinator

Curriculum Vitae -8- Frontrunner Safe-Steer (CATS Trial) FIRE CAPTIVE Pivotal ATBAT Gene Quest 1A Gamma I Gamma II Gamma IV Gamma V Beta Cath Accumetrics Gold ALIVE AMISTAD II ASCENT ATLAST BEST CROWN SIRIUS ERASER EDGE GR II MAJIC MINI Crown Medtronic High Scaffolding Registry PARAGON TARGET SCORES START WIN WINS STRATAS SUPRA G TOTAL STARS WIKTOR WIKTOR 6322 WIKTOR Fibrin CADILLAC SYNTAX PARTNERS CLOSYS SAPPHIRE DAPT WATCHMAN PROTECT AF PREVAIL INSTITUTIONAL/DEPARTMENTAL ADMINISTRATIVE RESPONSIBILITIES, COMMITTEE MEMBERSHIPS, AND OTHER ACTIVITIES:

Divisional Member, Cardiovascular Executive Committee (1985 to present) Director, Electrophysiology/Pacemaker Service (1981-1985) Director, Adult Cardiac Catheterization Laboratory (1984 to 1998) Director, Cardiac Catheterization Laboratory (1998 to 2003) Data Safety and Monitoring Boards Head Data Safety & Monitoring Committee STRATUS Trial (1996-1997) Head Data Safety & Monitoring Committee VEGAS Trial (1997 -present) Member, Data Safety and Monitoring Committee Carotid Stent Study (1997 -present) INSPIRE (2000-present) FINESSE Trial (2001-present) CREDO (1999-2001) Chugai PREVAIL Study (2001-present) Scientific Committee Member, Cardiovascular Continuum Council (2003) David R. Holmes Jr., M.D. Curriculum Vitae -9- RESEARCH INTERESTS: Left atrial appendage for stroke prevention Evaluation of patients undergoing balloon angioplasty Evaluation of digital angiography and digital processing for coronary flow and coronary velocity Stenosis sizing with quantitative angiography Evaluation of patients with pre-excitation syndrome Evaluation of noninvasive methods of arrhythmia detection and treatment Development of balloon valvuloplasty Development of cardiovascular laser therapy Development of coronary atherectomy Intracoronary ultrasound Intracoronary endoprostheses Restenosis Simulation Technology Local Gene Therapy Myocyte injection for congestive heart failure Treatment of acute ischemic syndromes Stent placement Vascular brachytherapy