Participating centers Austria. Bulgaria. Czech Republic. Belgium SUPPLEMENTARY DATA

Human Reproduction, Vol.0, No.0 pp. 1 33, 2014 doi:10.1093/humrep/deu175_suppl SUPPLEMENTARY DATA Participating centers Austria Bregenz: Institut für Reproduktionsmedizin und Endokrinologie Dobl: Kinderwunschinstitut Schenk Feldkirch: Kinderwunschzentrum Landeskrankenhaus Feldkirch Graz: Institut für In-Vitro-Fertilisierung und Endokrinologie; Institut für Hormonstörungen Wechselbeschwerden und Kinderwunsch; A. ö. Landeskrankenhaus Graz Horn: Landesklinikum Waldviertel Horn Innsbruck: Landeskrankenhaus-Universitätskliniken Innsbruck; Private Kinderwunschklinik Dr Josef Zech GmbH; WOMED Therapiezentrum Kinderwunsch GmbH Klagenfurt: Sterignost Kinderwunschbehandlungs GmbH Krumpendorf: Privatkrankenanstalt Parkvilla Linz: Landes-Frauen- und Kinderklinik Oberpullendorf: A. Ö. Krankenhaus Oberpullendorf St. Pölten: Landesklinikum St. Pölten Salzburg: IVF-Zentren Prof. Zech Salzburg GmbH; Landeskrankenhaus Salzburg Universitätsklinikum der PMU; Babywunsch-Klinik Dr Zajc GmbH Vienna: Allgemeines Krankenhaus der Stadt Wien; Goldenes Kreuz; GYNANDRON Dr Freude; Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel; Wunschbaby-Zentrum, Institut für Kinderwunsch; Adebar Institut für Reproduktionsmedizin und Psychosomatik der Sterilität; Privat Klinik Wien Währing; Fertilitätszentrum Döbling Wels-Thalheim: Die KinderWunschKlinik Dr Loimer GmbH Belgium Antwerpen: Dienst Fertiliteit, Algemeen Ziekenhuis Middelheim Braine L alleud: Centre de Fécondation C.H. Interregional Edith Cavell (CHIREC), Brugge: BIRTH Fertiliteitskliniek, Algemeen Ziekenhuis Sint-Jan Brussel: Centrum voor Reproductieve Geneeskunde, UZ Brussel; Clinique de Procréation Médicalement Assistée, Hôpital Universitaire Saint- Pierre U.L.B.; Service de Gynécologie, Cliniques Universitaires Saint-Luc U.C.L.; Centre de FIV de l U.L.B. Hôpital Erasme Charleroi: Service Gyn/Obst, Clinique Notre Dame Edegem: Centrum voor Reproductieve Geneeskunde, Universitair Ziekenhuis Antwerpen U.I.A., Genk: Centre for Reproductive Medicine, Ziekenhuis Oost-Limburg St. Jan Gent: Vrouwenkliniek- Infertiliteitscentrum, U.Z. Gent; Centrum voor Fertiliteitstherapie, A.Z. Jan Palfijn Leuven: dienst Gynaecologie, Universitaire Zieknhuizen K.U.Leuven Gasthuisberg; Unit Reproductieve Geneeskunde, Regionaal Ziekenhuis Heilig Hart Libramont: Centre d Infertilité, Centre Hospitalier de l Ardenne Liege: Centre de FIV, Centre Hospitalier Régional de la Citadelle Namur: Service Gynéco, Centre Hospitalier Régional de Namur Rocourt: Centre Liégeois pour l étude et le traitement de la stérilité, Clinique Saint Vincent Bulgaria Pleven: Clinical Institute for Reproductive Medicine Plovdiv: Medical center BORA Sofia: In Vitro Gynecological center Todorov Brothers ; In Vitro Medical center J Dimitrov ; Ob/Gyn Hospital Dr Shterev Varna: Medical Center for assisted reproduction Varna ; Medical Center Olimed ; Medical Center Maichin Dom Czech Republic Brno: MUDr. Ales Bourek; REPROMEDA, s.r.o.; Sanatorium HELIOS, s.r.o.; CAR 01 Brno, Gyn. por. klinika FN Brno; UNICA, s.r.o.; Reprofit International s.r.o. Ceské Budejovice: Sanatorium ART, s.r.o. Hradec Kralove: SANUS, s.r.o. Jihlava: Sanus Jihlava Karlovy Vary: Institut reprodukční medicíny a genetiky, s.r.o.; Pronatal SPA, s.r.o. Kostelec nad Orlicí: ARLETA IVF, s.r.o. Liberec: Gennet Liberec Olomouc: Fakultni nemocnice Olomouc, CAR, Por.-gyn. Klinika; FER- TIMED, s.r.o. Ostrava: GYNCENTRUM Ostrava, s.r.o. Pardubice: SANUS Pardubice Plzen: Fakultní nemocnice Plzeň, CAR, Gyn.-por. Klinika; IVF Zentren Prof. Zech Pilsen s.r.o.; NATALART, s.r.o Praha: Fakultní nemocnice v Motole, CAR, Gyn.- por. klinika 2. LF UK; GENNET, s.r.o. Praha; GEST, s.r.o.; ISCARE I.V.F., a.s.; PRAGUE FERTILITY CENTRE s.r.o.; Pronatal Plus, s.r.o.; PRONATAL, s.r.o.; Ústav pro péči o matku a dítě; Všeobecná fakultní nemocnice v Praze, CAR, Gyn.- por. klinika 1. LF UK & The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

2 Teplice: Pronatal Nord, s.r.o Zlín: IVF Czech Republic, s.r.o. Denmark Aalborg: Faurskov Fertilitet og Ultralyd Aarhus: Aagaard Fertilitetsklinik; Privathospitalet Ciconia; Fertilitetsklinikken Skejby Sygehus; Maigaards Fertilitetsklinik Brædstup: Fertilitetsklinikken Brædstrup Sygehus Copenhagen: Dansk Fertilitetsklinik; Fertilitetsklinikken IVF; Fertilitetsklinikken Herlev Sygehus; Fertilitetsklinikken Hvidovre Hospital; Fertilitetsklinikken Rigshospitalet; Fertilitetsklinikken Trianglen; Copenhagen Fertility Center; VitaNova Dronninglund: Fertilitetsklinikken Dronninglund Fredericia: IVF-SYD Holbæk: Fertilitetsklinikken Holbæk Sygehus Odense: Fertilitetsklinikken Odense Universitetshospital; Odense IVF-Klinik Skive: Fertilitetsklinikken Skive Sygehus Finland Helsinki: Family Federation of Finland Helsinki; Felicitas; Fertinova; Graviditas; Helsinki University Central Hospital Joensuu: Northern Carelia Central Hospital Jyväskylä: In-Tiimi Jyväskylä Kuopio: In-Tiimi Kuopio; Kuopio University Central Hospital Lappeenranta: Felicitas Oulu: Family Federation of Finland Oulu; Oulu University Central Hospital Tampere: AVA Tampere; Ovumia; Tampere University Central Hospital Turku: AVA Turku; Family Federation of Finland Turku; Turku University Central Hospital France Agen: LBM G 2 BIO; LBM Olivot Mariotti Aix en Provence: Site d Aix en Provence, lbm Celse l Hoste; Lbm Solet Llorca, site Aix en Provence, Lbm Cardinal Amiens: Groupe Santé Victor Pauchet; Centre De Gyneco Obstetrique CHU Amiens Angers: C.H.U. D Angers; Lbm Andebio Angoulème: Laboratoire Labio 16 (2) Annecy: Lbm Biolac site Annecy; Labm Goguey Lorenter Jouval Annemasse: Hopital de Bonneville, lbm Bioalp Antibes: Lbm Soleau Antony: Labm Selas Laboratoires Velpeau; Lbm Novescia SiteVelpeau Argenteuil: Centre Hospitalier Victor Dupouy Auxerre Lbm Selas des Cordeliers Clairions Avignon: Polyclinique Urbain V, Lbm Biotop site Maison d Asclepios Bagnolet: Clinique de La Dhuys, Selafa Labm ZTP Bar le Duc: Lbm Syndibio Monvoisin Bastia: Lbm Vialle site de Lupino Bayonne: Capio Clinique Lafargue, lbm Ax Bio Ocean Beaumont: Clinique La Chataigneraie Bergerac: Lbm Novabio Besancon: CHU Saint Jacques; Polyclinique de Franche-Comté Béziers: Lbm Labosud OC Biologie Beziers BITERR Bollène: Labm Martin Pertris Bollène Bondy: Hopital Jean Verdier Bordeaux: Groupe Hospitalier Pellegrin CHU; Polyclinique Jean Villar, Lbm Bioffice Bourg en Bresse: Labm Bretin Megevand Brest: CHRU hopital Morvan; Clinique Pasteur Lanroze Brive la Gaillarde: Lbm Bioreze Brive Berthelot; Labo Leymarie Labro Chambon Bron: Hopital femme Mère Enfant Bussy Saint Georges: Lbm Bio vsm lab Caen: CHU Côte De Nacre CAEN; Labm Malherbe Calais: CH Calais; Laboratoire Principal Centre biologique Cannes: Labm Demes Castres: Lbm Novescia Midi-Pyrenées Cayenne: Centre Hospitalier de Cayenne Cernay: Labm Monnier Chalon sur Saone: Biolab Unilabs Chalon Boucicaut Chambery: Lbm MS Laboschambery Chambery Siege Chambray-Les-Tours: Pole Sante Leonard de Vinci/ Lbm l Abo+ Chambray Leonard de Vinci Champigny Sur Marne: CHI de Creteil, lbm Biomega Charleville-Mezieres: Hopital Manchester CH Charleville; Lbm Bio Ard Aisne Cholet: Lbm Xlabs; Lbm Biomelis Clamart: Hopital Antoine Béclère; Labm Benhaim site Jean Jaures Clermont-Ferrand: CHU Estaing Colmar: Lbm Barrand Alsace Compiegne: Lbm Biocôme Compiegne Bernard Cormeilles En Parisis: Clinique du Parisis Coutances: Lbm Multi sites Biocentre Créteil: Lbm Bio Epine Site Creteil Soleil Dax: Lbm Forte Bio Dijon: Hopital Le Bocage CHU Dijon; Lbm Biopole 21 dijon Vaillant; Lbm Bruant Dijon Draguignan: Labm Cammilleri Poillon Ville Dreux: CH Dreux Dunkerque: Laboratoire Principal Enghien Les Bains: Lbm Bio Paris Ouest Site Enghiene Epinal: Clinique L Arc en ciel Equeudreville Hainneville: Polyclinique du Cotentin Ermont: Clinique Claude Bernard Flers: CH Jacques Monod Flers Henin Beaumont: Laboratoire Secondaire Griere Lobry Kaysersberg: Lbm Cab site Vignoble La Roche sur Yon: Lbm Biorylis La Rochelle: Clinique du Mail La Rochelle La Tronche: Hopital Nord Lannion: Labm. Labazur Armorique Laval: Lbm Biolaris Le Blanc Mesnil: Hopital Prive De La Seine Saint Denis/Lbm Clement Fresnais Hamidi Minz Le Chesnay: Centre Medico Chirurgical de Parly II Le Coudray: CH Chartres Louis Pasteur Le Coudray Le Havre: Hopital Jacques Monod Ch Le Havre/Labm Rocaboy and Chevallier Helas Le Mans: Clinique du Tertre Rouge

3 Le Port: Clinique Jeanne d Arc Lens: CH Lens Les Abymes: CHU de Pointe a Pitre/Abymes Libourne: Lbm Aquilab Lille: Polyclinique du Bois; Hop Jeanne de Flandre CHR Lille; Laboratoire Secondaire Biolille Limoges: CHU Dupuytren Limoges; Labm Biolyss L Isle d Abeau: Lbm Noviale Lorient: Centre Hospitalier Bretagne Sud Lyon 2ieme: Lbm Dyomedea Lyon 7ieme: Clinique Du Val d Ouest Vendome, laboratoire Biomnis; Clinique du Tonkin, Laboratoire biomnis Lyon 8ieme: Hop Prive Mere Enfant Natecia/Lbm Novescia Rhone Alpes Macon: Lbm Medilabs Marseille 5ieme: APHM Hopital de la Conception Marseille 8ieme: Hopital St Joseph; Clinique Bouchard, Lbm Giorgetti Marseille 12ieme: Lbm JS Bio Metz: Hopital Maternité de Metz,/Labm Espacebio Stahl Kuntzel Mont de Marsan: Lbm Landes Biologie Medicale Montauban: Lbm Bio Fusion Montpellier: Hopital Araud de Villeneuve CHU MPT; Polyclinique Saint Roch; Mulhouse: Clinique Diaconat Roosevelt, Lbm du Diaconat; Lbm Cab site Pegon; Hopital Emile Muller Nancy: Polyclinque Majorelle; Maternité Régionale A Pinard; CHU Nantes site Hotel Dieu Hme; Clinique Breteche; Clinique J.Verne Pole Hosp mutualiste Nantes: C.H.U. Nantes Hotel Dieu et hoe; Clinique Breteche Viaud Site Breteche; Clinique J. Verne Pole Hosp mutualiste Neuilly sur Seine: Hôpital Américain; CH de Courbevoie Neuilly Puteaux Nevers: Lbm Scp G.Ferrand Nevers Nice: Labm Delpech Zerbib; Clinique Saint Georges; Chu De Nice Hopital De L archet Nimes: Groupe Hospitalier Caremeau CHU Nimes; Lab.Fourquet Goulesque; Laboratoire Bebin Cabrol Niort: Laboratoire Medilab Group (4) S Orleans: Centre Hospitalier regional d Orleans; Labm SELAS Biosynthèse Paris 5ieme: Lbm Selas Sante Bio Site Saint Germain Paris 9ieme: Hopital Des Diaconesses/Labm Drouot; Hopital Pierre Rouques Les Bluets /Labm Drouot Paris 10ieme: Labm Magenta Paris 13ieme: Groupe Hosp. Pitié Salpétrière Paris 14ieme: Hopital Cochin St Vincent Paul; Institut mutualiste Montsouris; Lbm Bio Epine Site Denfert; Lbm Selas Cbcv Site Bd Saint Jacques Paris 15ieme: Lbm La Scala Paris 16ieme: Clinique de La Muette; Lbm Eylau Unilabs Site Saint Didier; Ctre Chirurgical Pierre Cherest/Lbm Eylau Unilabs Site Saint Didier Paris 18ieme: G.I.H. Bichat/Claude Bernard Paris 19ieme: Lbm Bio Path Crimee Paris 20ieme: Hopital Tenon Pau: Polyclinique de Navarre Perigueux: Polyclinique Francheville Perpignan: Clinique Saint Pierre Pointe a Pitre: Laboratoire Espiand Girard Poissy: C.H. Int. De Poissy/St Germain en Laye Poitiers: CHU La Miletrie Quimper: Chic. Quimper; Lbm Ty Bio Reims: Polyclinique de Courlancy/Lbm Courlancy ; Polyclinique de Courlancy/Lbm de la Porte de Paris; Hopital Maison Blanche CHR Reims; Hopital Manchester CH Charleville/Lbm de la Porte de Paris Rennes: C.H.R. Hopital Sud; Clinique mutualiste La Sagesse Roanne: Ch De Roanne/Lbm Glbm Roanne/Tanneries Rodez: Lbm Cayrou Gorse Bourjeili Rouen: Hopital Charles Nicolle CHU Rouen; Clinique Mathilde Rouen/ Lbm Multi Sites Bio Seine Saint Brieuc: Labo. Curunet Geoffroy Saint Herblain: Polyclinique de L Atlantique Saint Malo: Lbm Bio Emeraude St Malo Desilles Saint-Martin de Boulogne: SAS Centre M.C.O. Cote D Opale Saint Martin d Heres: Clinique Belledonne Saint Nazaire: Centre hospitalier de St. Nazaire Saint Pierre: GHRS Réunion Saint Priest en Jarez: Hopital Nord Saintes: Laboratoire Cerdibio Charentes Sarreguemines: Labm Medilab est Schiltigheim: SIHCUS/CMCO Schoelcher: Clinique Sainte Marie Senlis: CH GHPSO Senlis/Lbm Biomag Senlis Sens: Labm Dehenry Melin Sevres: Ch Des 4 Villes Site Sevres Soissons: Centre Hospitalier de Soissons Strasbourg: Lbm des Vosges; Lbm Klumpp Tarbes: Lbm Top Bio Thiais: Lbm Bio Epine Toulon: Clinique Saint Michel/Labm Cohen Billiemaz Toulouse: Hopitaux Mere & Enfants Chu Tlse/Hopitaux Mere & Enfants Chu Tlse; Clinique De L union/lbm Montagut Rousselle De Mas; Lbm Cedibio Unilabs; Clinique Saint Jean Languedoc/Lbm Montagut Rousselle De Mas Tours: C.H.R.U. Bretonneau Tours Troyes: Labm Biolavi Valence: Clinique Pasteur/Labm de Clercq Valenciennes: Clinique du Parc/Laboratoire Principal Biogroup Vannes: Lbm Ocealab Site Kerlann Vannes Villefranche sur Saone: Labm Ingels Vignon Vitry Sur Seine: Clinique des Noriets/Lbm Bio Path VitryS/Seine Germany Aachen: Frauenarztpraxis mit Schwerpunkt Gynäkologische Endokrinologie und Reproduktionsmedizin, Dr med. Klaus-Michael Grunwald, Aachen; Universitäts-Frauenklinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Med. Fakultät der RWTH Aachen, Prof. Dr med. Joseph Neulen, Dr med. Benjamin Rösing, Dr rer. nat. Ute Weißenborn, Aachen Aalen: Aalener IVF-Zentrum, Dr Rainer Rau, Dr Birgit Schröppel, Dr Roland Eid (Biologe), Aalen Augsburg: IVF-Zentrum Augsburg, Dr med. K.-F. Hiller, Dr med. T. H. Bauer, Dr H. Kraus, Augsburg Bad Münder: Deutsche Klinik Bad Münder, Zentrum für Reproduktionsmedizin, MVZ wagnerstibbe GmbH, Bispink, Chandra, Breitbach, Hinrichsen, Peper, Bad Münder

4 Bayreuth: Klinik am Hofgarten, Kinderwunschzentrum Bayreuth, Dr Stefan Todorow, Bayreuth Bedburg/Erft: Gemeinschaftspraxis Dr med. Dieter Struller, Dr med. Christof Etien, Bedburg Berlin: Arbeitsgruppe Endokrinologie & Reproduktionsmedizin im Lützow Center, Dr med. Detlef H.G. Temme and Kollegen, Berlin; Fertility Center Berlin, Prof. Dr med. H. Kentenich, Dr med. A. Siemann, Dr med. G. Stief, Dr med. A. Tandler-Schneider, Berlin; Frauenarztpraxis Kinderwunschzentrum Helle Mitte, Berlin; Kinderwunschzentrum am Innsbrucker Platz Berlin, Babette Remberg, Dr med. Susanne Tewordt- Thyselius, Gyn. Endokrinologie und Reproduktionsmedizin, Berlin; Kinderwunschzentrum an der Gedächtniskirche, Dr Matthias Bloechle, Dr Silke Marr in Praxisgemeinschaft mit der Gemeinschaftspraxis Dr Hanadi Awwadeh, Dr Anja Mutz in Praxisgemeinschaft mit der Gemeinschaftspraxis Dr Birgit Roth, Carola Kadgien, Berlin; Kinderwunschzentrum Berlin, Akademische Lehrpraxis der Charité Universitätsmedizin, Frauenärztliche Gemeinschaftspraxis Dr med. Reinhard Hannen, Dr med. Christian F. Stoll, Berlin; Kinderwunschzentrum FERA im Wenckebach-Klinikum, Dr Andreas Jantke, Dr Sofia Spindeldreher, Dr Anna Stegelmann, Dr Manzoor Nowshari, Berlin; Praxisklinik für Fertilität, Dr med. Peter Sydow/Dr med. David J. Peet, Dr med. Carmen Sydow, Dr med. Ulrike Bergmann-Hensel, Berlin; Universitätsmedizin Berlin Charité Kinderwunschzentrum, Dr med. B. Pfüller, Dr med. J. Bartley, Dr med. I. Scheiber, Dr rer. nat. H. Schmiady, Berlin Bielefeld: Bielefeld Fertility Center, Paul A. Ebert, Dr Karl Völklein, Beata Szypajlo, Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie, Bielefeld; Bielefelder Institut für Fortpflanzungsmedizin BIF, Dr Beate Harms, Dr Nabaz Baban, Bielefeld Bocholt: Fertility Center Münsterland, Dr med. Ulrich Hilland, Bocholt Bochum: VITRO-MED Kinderwunschzentrum Bochum, Yvonne Giesner, Bochum Bonn: Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Bonn, Prof. Dr med. Hans van der Ven, Prof. Dr med. Katrin van der Ven, Dr med. Ulrike Bohlen, Prof. Dr rer. nat. Markus Montag, Bonn; Praxisklinik für gynäkologische Endokrinologie und Reproduktionsmedizin, Priv.-Doz. Dr med. Gernot Prietl, Bonn-Bad Godesberg Bremen: Bremer Zentrum für Fortpflanzungsmedizin (BZF), Dr Olaf Drost, Prof. Dr Ernst Heinrich Schmidt, Bremen; Kinderwunsch Bremen, Dr Achim v. Stutterheim, Tanja Finger, Dr Susanne Meyer- Ströh, Bremen Chemnitz: Kinderwunschzentrum Leipzig Chemnitz, Dres. P. Jogschies, D. Geistert, L. Shugair, A. Lahl; Kinderwunschzentrum Praxisklinik City Leipzig, Standort Chemnitz, Dr med. Astrid Gabert, Dr med. Katharina Bauer, Dr med. Georg Saager Darmstadt: Kinderwunschzentrum Darmstadt, Prof. Dr med. G. Leyendecker, Dr med. A. Bilgicyildirim, Dr med. M. Inacker, Darmstadt Deggendorf: Kinderwunschzentrum Niederbayern, Dr med. Hans J. Kroiss, Dr med. E. Bernhardt, Dr med. Anja Bräuker, Dipl. Biologin Heike Vornehm, Edith Wilhelm, Deggendorf Dortmund: Kinderwunschzentren Dortmund u. Siegen, Gemeinschaftspraxis Prof. Dr med. Stefan Dieterle, Dr med. Andreas Neuer, Prof. Dr med. Robert Greb, Dortmund und Siegen Dresden: Praxisklinik Dr med. Hans-Jürgen Held, Dresden; Universitätsklinikum Carl Gustav Carus Dresden Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Prof. Dr med. W. Distler, Dr rer. nat. G. Keck, Dr med. E. Gouma, Dresden Düsseldorf: UniKiD, Universitäres interdisziplinäres Kinderwunschzentrum Düsseldorf, Frauenklinik der Heinrich-Heine-Universität, Prof. Dr med. Jan-Steffen Krüssel, Dr med. Alexandra Hess, Dr med. Barbara Mikat-Drozdzynski, Dr med. Andrea Schanz, Dr rer. nat. Jens Hirchenhain, Düsseldorf; Zentrum für interdisziplinäre Kinderwunschbehandlung Düsseldorf, Dr M. Scholtes, Ph. D., Dipl.-med. K. Marx, Priv.-Doz. Dr med. S. Kißler, Dr med. Martina Behler, Dr med. S. Pfeiffer, Dr med. Petra Hubert, Tanja Emde, Dr med. Selma Yildirim-Assaf, Düsseldorf Erlangen: Gemeinschaftspraxis der Frauenärzte, Zentrum für Reproduktionsmedizin, Dr Miklos Hamori, Dr Rolf Behrens, Dr Andreas Hammel, Erlangen; Kinderwunschzentrum Erlangen, Dr med. J. Van Uem, Erlangen; Universitäts-Fortpflanzungszentrum Franken (UFF), Prof. Dr med. M. W. Beckmann, PD Dr med. Andreas Müller, Prof. Dr rer. nat. Ralf Dittrich (Biologe), Erlangen Essen: NOVUM Zentrum für Reproduktionsmedizin Essen Duisburg, Prof. Dr T. Katzorke, Dr Dirk Propping, Dr Susanne Wohlers, Prof. Dr P. Bielfeld, Essen Esslingen: IVF-Zentrum Esslingen, Dr med. J. E. Costea, Esslingen Frankfurt/Main: Fertilitätszentrum und Gynäkologische Endokrinologie, Universitätsfrauenklinik Frankfurt am Main, PD Dr med. Inka Wiegratz, Frankfurt am Main; Kinderwunschzentrum Frankfurt am Main, am Krankenhaus Nordwest, Prof. Dr med. E. Merz, Frankfurt am Main; Zentrum für Reproduktionsmedizin, Prof. Dr Ernst Siebzehnrübl, Dr Anja Weidner, Frankfurt Freiburg: Centrum für Gynäkologische Endokrinologie & Reproduktionsmedizin Freiburg (CERF), Gemeinschaftspraxis Dr Weitzell, Dr Thiemann, PD Dr Wetzka, Prof. F. Geisthövel, Freiburg; Klinik für Endokrinologie u. Reproduktionsmedizin, Universitäts-Frauenklinik Freiburg, Dr S. Friebel, Dr A. Hanjalic-Beck, Prof. H.P. Zahradnik, Freiburg Gelsenkirchen: Kinderwunschpraxis Gelsenkirchen, Dr med. Ute Czeromin, Dr med. Ina Walter-Göbel, Dr med. Kathrin Fißeler, Gelsenkirchen Göttingen: Georg-August-Universität Göttingen, Prof. Dr med. Dr Bernd Hinney, Prof. Dr Hans-Wilhelm Michelmann, Göttingen; Kinderwunschzentrum Göttingen, Dr Rüdiger Moltrecht, Dr Sabine Hübner, Dr Thomas Welcker, Dr Filiz Sakin-Kaindl, Dr Stephanie Mittmann, Dr Peter Schulzeck, Göttingen; Kinderwunschpraxis Göttingen, Reproduktionsmedizin/Gynäkologische Endokrinologie, Dr med. Monica Tobler, Jana Rostek, Göttingen Grevenbroich: green-ivf: Grevenbroicher Endokrinologikum & IVF- Zentrum, Dr J. Tigges, Dr K. Friol, PD Dr C. Gnoth, Grevenbroich Halle/Saale: Zentrum für Reproduktionsmedizin und Andrologie (ZRA), Universitätsklinikum Halle (Saale), Univ.-Prof. Dr med. Hermann M. Behre, Dr med. Petra Kaltwaßer, Dr rer. nat. Ewald Seliger Hamburg: Endokrinologikum Hamburg, Zentrum für Hormon- und Stoffwechselerkrankungen, Reproduktionsmedizin und Pränatale Medizin, Hamburg; Kinderwunschzentrum Altonaer Straße, GMP Dres. med. Bispink, Horn, Michel u. Partner, Dr Bispink, Dr Horn, Dr Michel, Dr Gohmann, Dr Aytekin, Dr Acar-Nosit, Hamburg; Kinderwunschzentrum Fleetinsel Hamburg, Dr med. Semsettin Kocak, Dr med. Peter List, Dr med. Uwe Weidner, Hamburg; MVZ Fertility Center Hamburg GmbH, Dr R. Fischer, Hamburg Hannover: Kinderwunschzentrum Langenhagen Wolfsburg, Dr Martina Müseler-Albers, Horst Peter Arendt, Dr Klaus Bühler, Dr Thilo Schill,

5 Langenhagen und Wolfsburg; Med. Hochschule Hannover, IVF-Labor, Fr. Dr Schippert, Fr. Dr Baßler, Hannover; Team Kinderwunsch Hannover, Dr Saymé und Kollegen, Werner Hoppenstedt, Hannover Heidelberg: Kinderwunschzentrum Heidelberg, Dr Waltraud Parta-Kehry, Dr Suat Parta, Friederike Tesarz, Dr Daniela Seehaus, Dr Christina Thöne, Heidelberg; Universitäts-Frauenklinik Heidelberg, Gynäkologische Endokrinologie und Fertilitätsstörungen, Prof. Dr Thomas Strowitzki, PD Dr Bettina Toth, Heidelberg Hildesheim: Zentrum für Reproduktionsmedizin u. Humangenetik Hildesheim, Dres. med. Algermissen, Justus, Wilke, Graf, Hildesheim Jena: Reproduktionsmedizinisches Zentrum Jena, Priv.-Doz. Dr med. habil. Heidi Fritzsche, Dipl.-med. Jens-Peter Reiher, Dr med. Angela Hoffmann; Universitätsfrauenklinik Jena, Prof. Dr med. Jürgen Weiss, Dr rer. nat. Ines Hoppe Karlsruhe: Karlsruher IVF-Programm, AG für Fortpflanzungsmedizin, Frauenarztpraxis H.J. Gräber, Dr V. Wetzel, Dr F. Tetens, Laborärzte Dr M. Linnemann und Kollegen, Humangenetik Dr G. Schlüter, Karlsruhe Kassel: MVZ für Reproduktionsmedizin am Klinikum Kassel, Dr med. Marc Janos Willi, Dr med. Oswald Schmidt, Prof. Dr med. Miguel Hinrichsen, Kassel Kempten: KWK KinderWunschKempten, Zentrum für Reproduktionsmedizin, Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Kempten ggmbh, Prof. Dr med. Ricardo Felberbaum, OA Gerhard Allgayer, Dr med. Daniela Hiltensberger, Dipl. Biol. Mohammad Kousehlar, Kempten Kiel: fertilitycenterkiel, Priv.-Doz. Dr Sören von Otte, Dr Volker Schulz, Dr Martin Völckers, Dr Heike Eckel, Kiel; Kinderwunschzentrum am UK-SH, Campus Kiel, Dr Andreas Schmutzler, Prof. Dr Ali Salmassi, Kiel; Kinderwunsch Kiel, Dr med. K. Brandenburg, Dr sc. agr. A. Bonhoff, Dr med. A. Carstensen, Kiel Köln: Kinderwunschzentrum-Köln Praxis und Klinik Schoenhauserstraße, Dr med. Markus Merzenich, Kinderwunschzentrum Köln Eva, Schwahn, Köln; PAN Institut für Endokrinologie u. Reproduktionsmedizin, Dr Stefan Palm, Dr Irene Pütz, Dr Mirko Dannhof, Prof. Dr Christoph Keck, Priv.-Doz. Dolores Foth, Köln; Uniklinik Köln, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Dr G. Rahimi, Dr C. Moers, I. Orth, Köln Leer: Zentrum für Reproduktionsmedizin, Gyn, Dr med. Wolfgang von der Burg, Leer Leipzig: Zentrum für Reproduktionsmedizin, Gynäkologische Endokrinologie und Sexualmedizin, Prof. Dr med. H. Alexander, Dipl.-Biol. W. Weber; Kinderwunschzentrum Leipzig-Chemnitz, Dres. F.A. Hmeidan, P. Jogschies, D. Geistert L. Shugair, A. Lahl; Kinderwunschzentrum Praxisklinik City Leipzig, Standort Leipzig, Dr med. Astrid Gabert, Dr med. Katharina Bauer, Dr med. Georg Saager Lübeck: UKL-Universitäres Kinderwunschzentrum Lübeck, Zentrum für Reproduktionsmedizin und Gynäkologische Endokrinologie am Universitätsklinikum Schleswig-Holstein, MVZ Ambulanzzentrum des UK-SH GmbH, Prof. Dr med. G. Griesinger, Priv.-Doz. Dr med. A. Schultze-Mosgau, Prof. Dr med. K. Diedrich, Lübeck Ludwigshafen: Kinderwunschzentrum Ludwigshafen, Dr med. Tobias Schmidt, Dr med. Claudia Schmidt, Dr rer. nat. Nicole Motzkus, Ludwigshafen Magdeburg: Kinderwunschzentrum Magdeburg, Dr med. Ingrid Nickel, Dr med. Evelyn Richter, Magdeburg; Universitätsklinik für Reproduktionsmedizin u. Gyn. Endokrinologie, Prof. Dr med. J. Kleinstein, Dr med. A. B. Brössner, Magdeburg Mannheim: Kinderwunschzentrum Mannheim, Klinikdirektor Prof. Dr med. M. Sütterlin, Dr med. R. Schaffelder, PD Dr med. St. Bussen Dr med. J. Schüttler, Dr Gentili, Mannheim Mainz: Kinderwunschzentrum der Universitätsmedizin Mainz, Univ.-Prof. Dr Rudolf Seufert M.Sc., Fr. Dr V. Passuello, Univ. Prof. Dr H. Kölbl, Mainz; Kinderwunsch Zentrum Mainz, Dr med. Robert Emig, Dr med. Silke Mettlin, Mainz Marburg: Universitätsklinikum Gießen Marburg GmbH, Standort Marburg Klinik für Gynäkologie, gyn. Endokrinologie u. Onkologie Schwerpunkt gyn. Endokrinologie, Reproduktionsmedizin und Osteologie, Prof. Dr med. Peyman Hadji, Prof. Dr med. Uwe Wagner, Dr med. Volker Ziller, Marburg Minden: Zentrum für Kinderwunschbehandlung und Pränataldiagnostik Minden, Dr med. Dipl.-Biochem. Onno Buurman, Dr med. Michael Dumschat, Dr med. Ralf Menkhaus, Dr med. Barbara Heidecker, Minden Mönchengladbach: Kinderwunschzentrum Mönchengladbach, Dr med. Georg Döhmen, Dr med. Thomas Schalk, Mönchengladbach München: A.R.T. Bogenhausen, Prof. Dr med. Dieter Berg, Dr med. Bernd Lesoine, München; Gynäkologische Endokrinologie und Reproduktionsmedizin der Uni München Innenstadt, Ludwig-Maximilians-Universität (LMU), Frauenklinik Innenstadt, PD Dr med. M.S. Kupka, Dr rer. nat. P. Papadopoulos, München; Hormonund Kinderwunsch-Zentrum der LMU München-Großhadern, Leiter: Prof. Dr Christian J. Thaler, Leitende Embryologin: Dr rer. nat. Viktoria von Schönfeldt, Klinik und Poliklinik der Frauenheilkunde und Geburtshilfe, Direktor: Prof. Dr med. Klaus Friese, München; Hormon Zentrum München, Dr med. H. Lacher, Dr med. J. Puchta, Dr med. S. Michna, PD Dr med. H.-U. Pauer, München; Kinderwunsch Centrum München-Pasing, Dr med. Klaus Fiedler, Dr med. Irene von Hertwig, Dr med. Gottfried Krüsmann, Prof. Dr med. habil Wolfgang Würfel, Ina Laubert, Dr med. Claudia Santjohanser, Sabine Völker, Osama Meri, Dr med. Jan Krüsmann, München; Zentrum für Reproduktionsmedizin München, Dr med. Walter Bollmann, Dr Thomas Brückner, Dr med. Ulrich Noss, München Münster: Kinderwunschzentrum Münster, Dr med. L. Belkien, Dr med. C. Niehoff, Fachärzte für Frauenheilkunde u. Geburtshilfe, Münster; Kinderwunschsprechstunde Uniklinik Münster IVF-Bereich, OA Dr med. Schüring, Prof. Kiesel, Martina Kreimer, Prof. Kliesch, Münster Neubrandenburg: Kinderwunschzentrum Neubrandenburg, Prof. Dr med. Roland Sudik, Dr med. Konstanze Kissing-Pahl, Neubrandenburg Neuwied: Kinderwunschzentrum Mittelrhein Koblenz und Neuwied, Dr Josef Beran, Dr Birgit Müller, Koblenz und Neuwied Nürnberg: Kinderwunsch- und Frauen-Hormon-Centrum Nürnberg, Dr Barbara Munzer-Neuwinger, Dr Joachim Neuwinger, Prof. Dr Peter Licht, Nürnberg Offenbach: Kinderwunschzentrum am Büsing Park, Dr med. K. Manolopoulos, Offenbach Oldenburg: Tagesklinik Oldenburg, Zentrum für Kinderwunschbehandlung, Dr med. Jörg Hennefründ, Dr med. Heike Boppert (vormals Ochs-Ring), Dr med. Michael Heeder, Oldenburg; Team Kinderwunsch Oldenburg, Dr med. Saif Jibril, Dr med. Gerhard Pohlig, Fachärzte für Frauenheilkunde und Geburtshilfe, Oldenburg Osnabrück: Zentrum für Kinderwunschbehandlung Osnabrück, Irene Coordes, Dr med. Manfred Schneider, Osnabrück Pforzheim: Centrum für Kinderwunsch Pforzheim, Verena Peuten, Pforzheim 515

6 Prien am Chiemsee: Kinderwunsch Centrum Chiemsee, Dr med. Susann Boehm, Dr med. Matthias Lehnert, Prien am Chiemsee. Recklinghausen: Reprovita, Kinderwunschzentrum Recklinghausen, Recklinghausen Regensburg: Kinderwunschzentrum Regensburg, Prof. Dr med. Bernd Seifert, Prof. Dr med. Monika Bals-Pratsch, Regensburg Remscheid: Institut für Gynäkologische Endokrinologie und Reproduktionsmedizin Remscheid, Dr med. J. Luckhaus, Remscheid Rostock: Praxiszentrum Frauenheilkunde, PD Dr med. H. Müller, A. Busecke, A. Bossow, Rostock Saarbrücken: Überregionale Gemeinschaftspraxis IVF-Saar Saarbrücken- Kaiserslautern, Drs med. M. Thaele, L. Happel, A. Giebel, N. Nassar, M. Otte, Saarbrücken und Kaiserslautern Stuttgart: Frauenarztpraxis mit Tagesklinik, Reproduktionsmedizin, Prof. Dr. med. Ute Fuchs, Stuttgart; Gynäkologie und Reproduktionsmedizin, Dr med. Fred Maleika, Dipl. Biol. Dr rer. nat. Silvia Harrer, Stuttgart; Kinderwunsch-Zentrum-Stuttgart, Praxis Villa Haag, Dr D. B. Mayer-Eichberger, Stuttgart Trier: Praxisklinik Trier, Zentrum für Gynäkologische Endokrinologie & Reproduktionsmedizin, Dr med. M. Satari, Prof. Dr med. J.P. Hanker Wissenschaftspark (WIP), Trier Tübingen: KinderwunschPraxis Dres. Göhring, Dr med. Ulrich Göhring, Dr med. Inés Göhring, Tübingen; UFK-Tübingen, IVF-Zentrum, Dr Barbara Lawrenz, Dr Eva Neunhoeffer, Tübingen Ulm: Kinderwunschpraxis Ulm, Praxis Dr Gagsteiger, Ulm; Praxisklinik Frauenstraße Ulm, Kinderwunschzentrum Ulm, Prof. Dr med. K. Sterzik, Dr med. E. Strehler, Ulm; Sektion für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universität Ulm, Dr K. Hancke, Dr B. Seemann, Dr E. Isachenko, Dr B. Rosenbusch, Ulm Viernheim: Viernheimer Institut für Fertilität, PD. Dr med. Stefanie Volz-Köster, Dr med. Christina Nell, Dr sc. hum. Brigitte Hauff, Viernheim Wetzlar: Kinderwunschzentrum Mittelhessen, Dr med. A. Hajimohammad, B. Oels, Wetzlar Wiesbaden: MVZ Kinderwunschzentrum Wiesbaden, Dres. med. M. Schorsch, Th. Hahn, G. Adasz, K. Schilberz, Wiesbaden Würzburg: Universitäts-Frauenklinik Würzburg, Kinderwunschzentrum, Dr med. Torsten Frambach, Dr med. Thomas Bernar, Würzburg; Zentrum für Kinderwunsch, Pränataldiagnostik, Medizinische Genetik, Dr med. R. Mai, Dr med. W. Schmitt, Frau Dr med. L. Mulfinger, Würzburg Greece Athens: Eugonia; Neogenesis IVF Centre; Embryoland IVF Centre; IVF and Genetics; Fertility institute; EMBRYO A.R.T Crete: Mediterranean Fertility Centre and Genetics Chania Ioannia: IVF Unit of OB/GYN, Medical school, Ioannia University Thessaloniki: Unit of Human Assisted Reproductive medicine, Papageorgiou General Hospital Hungary Budapest: Division of Assisted Reproduction, 1st Departement of OB/ GYN, Semmelweis University, Faculty of Medicine; Department of OB/ GYN, St. John s Hospital; Devai Institute; Forgacs Institute; CIRIS Budapest Center for International Reproductive Institute and System; Róbert Károly Private Clinic; Versys Clinic; Kaáli Institute Debrecen: Kaáli Institute Gyõr: Kaáli Institute Pécs: Departement of OB/GYN, Pécs University of Medicine Szeged: Kaáli Institute Iceland Reykjavik: ART Medica-IVF Iceland Ireland Clane: Assisted Conception Unit, Clane General Hospital, Clane, Co Kildare Cork: Cork Fertility Centre, Fernhurst House, College Road, Cork Dublin: Human Assisted Reproduction Ireland (HARI), Rotunda Hospital, Dublin 1; Merrion Fertility Clinic, National Maternity Hospital, Dublin 2 Galway: Galway Fertility Unit, Brooklawn House, Galway Kilkenny: The Kilkenny Clinic, Green Hill, Kilkenny Italy Abano Terme: Centro PMA Casa di Cura Abano Terme. Ancona: Centro PMA Presidio Ospedaliero G. Salesi Aosta: Centro PMA Valle d Aosta Appiano Gentile: Le Bettulle Casa di Cura s.r.l. Unità di Procreazione Medico Assistita Arco: Centro Provinciale per la Procreazione Medicalmente Assistita Ospedale Alto Garda e Ledro; Gynepro srl Avellino: Fisiopatologia della Riproduzione e Sterilità di Coppia A.O.R.N. San Giuseppe Moscati di Avellino. Bari: Centro Medico San Luca ; Centro PMA Casa di Cura Santa Maria; U.O. di Fisiopatologia della Riproduzione Umana e Congelamento Gameti A.O. Policlinico Consorziale di Bari; Centro di Fisiopatologia della Riproduzione Umana e PMA U.O. Ostetricia e Ginecologia Ospedale Di Venere di Carbonara) Barletta: Pro Andros s.r.l. Battipaglia: Centro Embryos s.r.l. Benevento: Centro di Fisiopatologia della Riproduzione Umana AORN G.Rummo di Benevento Bergamo: Centro di Procreazione Medico Assistita Enrico Radici -U.O. Ostetricia e Ginecologia A.O. Ospedali Riuniti di Bergamo Bollate: Centro di Sterilità della Coppia U.O. Ostetricia e Ginecologia A.O. G. Salvini di Garbagnate P.O. Caduti Bollatesi Bologna: SISMER Soc. Italiana Studio Med. Ripr.; Tecnobios Procreazione s.r.l.; Poliambulatorio Privato GYNEPRO; Centro di Infertilità e Procreazione Medicalmente Assistita A.O. di Bologna Università degli studi di Bologna Policlinico S.Orsola Malpighi Bolzano: Centro Sterilità Ospedale dibolzano Bra: Centro PMA Casa di Cura Città di Bra Brescia: Centro di Fecondazione Medicalmente Assistita U.O. Ostetricia e Ginecologia Casa di Cura Istituto Clinico Città di Brescia Brindisi: Casa di Cura SALUS, PROBIOS s.r.l. Ginecologia Brunico: Centro di medicina della riproduzione umana e crioconservazione gameti Ospedale di Brunico.

7 Cagliari: Centro per la Diagnosi e Cura della sterilità di Coppia Università degli Studi di Cagliari Ospedale S. Giovanni di Dio di Cagliari; Servizio Ostetricia e Ginecologia Diagnosi Prenatale e Preimpianto Opedale Regionale per le Microcitemico di Cagliari Campobasso: Centro Procreazione Medico Assistita Ospedale Cardarelli Cantu: Centro Fisiopatologia della Riproduzione del P.O. di Cantù A.O. Sant Anna di Como Carmagnola: Lisa s.r.l. Caserta: CARAN srl Medicina e Biologia della Riproduzione; Centro Genesis Day-Surgery DTC Società Consortile s.r.l. ; Fisiopatologia della Riproduzione A.O. San Sebastiano di Caserta Castel Volturno: I.D.F. Clinica Pineta Grande Castelfranco Veneto: ISIDE s.r.l. Ambulatorio Specialistico per la Riproduzione Assistita Castelvetrano: Hermes s.r.l. Servizi Sanitari Selinuntini Catania: A.O. Cannizzaro U.O. Ginecologia e Ostetricia Servizio di PMA; ARNAS Garibaldi S. Luigi Unità di Fertilizzazione in Vitro U.O. di Andrologia ed Endocrinologia della Riproduzione P.O. Garibaldi; Azienda Ospedaliera Universitaria V. Emanuele Ferrarotto S. Bambino Unità Operativa di Patologia ostetrica del P.O.S. S. Bambino; Casa di Cura Falcidia srl; Centro di Medicina della Riproduzione e Infertilità; CRA s.r.l. Centro di Riproduzione Assistita; G.M.R. Ginecologia e Medicina della Riproduzione Cattolica: Ospedale Cervesi di Cattolica Chianciano Terme: CDM Centro Diagnosi Medica s.r.l.; Chianciano Salute Centro di Chirurgia Ambulatoriale Chieti: Casa di Cura Spatocco Centro I.E.M.A. Istituto Europeo Medicina della Riproduzione Abruzzese Citta Sant angelo: Casa di Cura Villa Serena del Dott. L. Petruzzi s.r.l. Cittadella: Centro di Fecondazione Medicalmente Assistita di Cittadella U.O.A. Ostetricia e Ginecologia Dipartimento Materno Infantile P.O. di Cittadella ULSS 15 Alta Padovana Conegliano: Centro Regionale Specializzato di Fisiopatologia della Riproduzione Ospedale Civile di Conegliano Erice: Casa di Cura Sant Anna Centro di PMA Fermo: Casa di Cura Palmatea Centro satellite SISMER Firenze: Centro di Fisiopatologia della Riproduzione Umana Università degli Studi di Firenze A.O. Careggi; Centro di Procreazione Assistita Demetra ; Florence Centro di Chirurgia Ambulatoriale ed Infertilità; Futura Diagnostica Medica Procreazione Medicalmente Assistita s.r.l. Fossano: Centro per la Riproduzione Umana Assistita Ospedale di Fossano Frattamaggiore: Centro Fecondazione Assistita P.O. S. Giovanni di Dio ASL N.3 di Napoli. Frosinone: Centro Medico Life Genova: Centro di Fisiopatologia della Riproduzione Umana Dipt. Ostetricia e Ginecologia Padiglione I Ospedale San Martino; Medicina della Riproduzione Ospedale Evangelico Internazionale Gioia Tauro: Gatjc Gioia Tauro Giugliano In Campania: Clinic Center HERA Centro HERA srl. Gragnano: Studio A.G.O.I. del Dott. A. M. Irollo Grosseto: Demetra Centro Grossetano per la Cura dell Infertilita Lamezia Terme: C.I.S. Medicina Della Riproduzione L Aquila: Centro di Procreazione Medicalmente Assistita U.O.S. Dip. FIVET Ospedale San Salvatore L Aquila Latina: U.O. Dipartimentale di Andrologia e Fisiopatologia della Riproduzione Ospedale S. Maria Goretti Lecce: Casa di Cura Prof Petrucciani Centro di Procreazione Medicalmente Assistita Livorno: Arca Service s.r.l. Lugo: Laboratorio di Fisiopatologia della Riproduzione Umana P.O. di Lugo Maddaloni: IATREION s.r.l. Medicina Polispecialistica Manerbio: Dipartimento di PMA U.O. Ostetricia e Ginecologia A.O. di Desenzano del Garda P.O. di Manerbio Mantova: Centro di Medicina della Riproduzione ed Endocrinologia Ginecologica U.O. Ostetricia e Ginecologia A.O. Carlo Poma Marostica: Salus S.r.l. Genera Marostica Mazara Del Vallo: Terzo Millenio s.r.l. Merano: EUBIOS Mercogliano: Centro di Fisiopatologia della Riproduzione Messina: Centro Riproduzione Umana Chirurgia Ambulatoriale CRU s.r.l.; U.S. Fisiopatologia della Riproduzione Umana Centro PMA Azienda Ospedaliera Papardo Milano: Andrologia e Riproduzione Assistita U.O. Urologia II A.O. San Paolo di Milano P.O. San Paolo; Casa di Cura IGEA Sezione Procreazione Medico Assistita; Centro di Fecondazione Assisitita Casa di Cura Città di Milano s.p.a. ; Centro di Procreazione Medico Assistita Istituto Clinico Città Studi Spa; Centro di Riproduzione Assistita U.O. Ostetricia e Ginecologia A.O. Luigi Sacco P.O. Luigi Sacco; Centro Scienze della Natalità I.R.C.C.S. Ospedale San Raffaele; Centro studi e trattamento per disturbi della fertilità U.O. Ostetricia e Ginecologia- A.O. Ospedale Niguarda Ca Granda; ESPA Centro Endocrinologia, Sterilità e PMA Ospedale M. Melloni A.O. Fatebenefratelli e Oftalmico U.O. Ostetricia e Ginecologia; Fondazione Ca Granda Ospedale Maggiore Policlinico U.O. Semplice Dipartimentale (UOSD) Centro Sterilità ; MATRIS Medici Associati per la Terapia e la Ricerca dell Infertilità e Sterilità; Servizi Sforza s.r.l. Medicina della Riproduzione Modena: Centro di Medicina della Riproduzione Dip.to Scienze Mediche e Chirurgiche Materno-Infantili e dell adulto Sez. di Ginecologia ed Ostetricia A.0. Università di Modena Policlinico Molfetta: One Day Surgery di Ginecologia Ostetricia Infertilità Monteriggioni: Centro Servizi Montearioso s.r.l. Montichiari: Centro di Procreazione Assistita U.O. Ostetricia e Ginecologia A.O. Ospedali Civili di Brescia P.O. di Montichiari Monza: Centro di Medicina della Riproduzione BIOGENESI- Istituti Clinici Zucchi Napoli: Biologia della Riproduzione Crm Napoli presso casa di cura Villa del Sole; Centro di Fecondazione Assistita Villa Bianca; Centro di PMA Clinica Mediterranea; Centro di Sterilità Az. Univ. Policlinico Università degli Studi di Napoli Federico I; Centro di Sterilità ed Infertilità Ospedale Internazionale Casa di Cura s.r.l.; Centro PMA del Dipartimento Assistenziale di Ostetricia, Ginecologia e Neonatologia A.O.U. Policlinico Seconda Università degli Studi di Napoli; U.O.S.C. Ostetricia e Ginecologia A.O.R.N. A. Cardarelli ; U.O.S.D. Medicina della Riproduzione P.O. S. Giovanni Bosco ASL NA 1 Noventa Vicentina: Centro di Procreazione Medico Assistita Presidio Ospedaliero II-Ospedale di Noventa Vicentina Oderzo: Centro per la Procreazione Medicalmente Assistita Gianluigi Beltrame -ospedale di Oderzo, ULSS9 Treviso

8 Ortona: Centro di Procreazione Medicalmente Assistita ASL n8 2 Università degli studi G. d Annunzio Chieti Pescara Ospedale Civile G. Bernabeo di Ortona Padova: Analisi Mediche Pavanello s.a.s.; Biotech PMA s.a.s. di Bruno Giuliana; Centro di Procreazione Medicalmente Assistita Università di Padova A.O. di Padova Clinica Ginecologica e Ostetrica; Diaz s.r.l. Casa di Cura Privata Centro di PMA GEMMA Palermo: Casa di Cura Candela Spa; Centro Andros s.r.l.; Centro di Biologia della Riproduzione; Centro di Fisipatologia della Riproduzione U.O. di Ostetricia e Ginecologia Ospedale Ingrassia Aienda U.S.L. 6 Palermo; Centro di PMA Policlinico di Palermo A.O.U.P. Giaccone Clinica Ostetrica Ginecologica Università di Palermo; Genesy s.r.l.; Nuova Casa di Cure Demma A.M.B.R.A.; Procreazioni Assistite Demetra; Servizio di Fisiopatologia della Riproduzione Umana della Casa di Cure Orestano s.r.l. Parma: Centro Incapacità Riproduttiva CIR Clinica Ostetrica e Ginecologica Azienda Ospedaliero-Universitaria di Parma Pavia: Centro di Ricerca per la PMA IRCCS Policlinico San Matteo Università degli Studi di Pavia Perugia: Servizio di Diagnosi e Cura della Riproduzione Umana Struttura Semplice Dipartimentale della Struttura Complessa di Ostetricia e Ginecologia Azienda Ospedaliera di Perugia Pesaro: Azienda Ospedaliera San Salvatore di Pesaro Pieve Di Cadore: Ospedale di Pieve di Cadore Pisa: Casa di Cura Privata San Rossore; Centro di Fisiopatologia della Riproduzione e Procreazione Assistita Università degli Studi di Pisa Ospedale Santa Chiara A.O. Pisana; Ponte San Pietro: Centro di Medicina della Riproduzione BIOGENESI U.O. Ostetricia e Ginecologia IRCCS Policlinico San Pietro Pordenone: Struttura Operativa Semplice di Fisiopatologia della Riproduzione Umana e Banca del Seme Potenza: Azienda Ospedaliera Regionale San Carlo Dipartimento della donna e del bambino U.O.C. Ostetricia e Ginecologia Procreazione Medicalmente Assistita Pozzuoli: UOSD Fisiopatologia della Riproduzione Umana Centro di PMA di II livello P.O.S. Maria delle Grazie Pozzuoli ASL NA2 nord Quartu Sant elena: Casa di Cura Policlinico Citta di Quartu Ragusa: Clinica del Mediterraneo Centro PMA ASTER Reggio Di Calabria: Biomeeting s.r.l. Reggio Nell Emilia: Centro per la Diagnosi e la Terapia della Sterilità Involontaria di Coppia P-Bertocchi -A.O. Arcispedale S. Maria Nuova; Studio Diagnostico Raoul Palmer s.r.l. Rende: LIFE LAB Studio Medico Specialistico di Riproduzione e Andrologia Roma: A.S.I.C. Associazione per lo Studio dell Infertilità di Coppia; Alma Res; Ambulatorio Sterilità della Fabia Mater ; Antinori Severino Centro RAPRUI Day Surgery Ristemo Medica srl; ARTEMISIA; C.I.P.A. Centro Italiano Procreazione Assistita; Casa di Cura Villa Salaria Servizio di Fisiopatologia della Riproduzione; Centro Biofertility; Centro di Scienze della Riproduzione e Natalità Villa Pia ; Centro di Sterilità Istituto di Ginecologia Policlinico A. Gemelli Università Cattolica del Sacro Cuore; Centro Genesis (c/o Clinica Villa Pia); Centro LEDA; Centro Procreazione Medicalmente Assistita A.O. San Filippo Neri ; Fisiopatologia della Riproduzione Umana U.O. di Ginecologia e Ostetricia Azienda Ospedaliera S. Camillo Forlanini; Genera Clinica Valle Giulia; Grimaldi Medical spa Centro Studi Fertilità di Coppia; Grimaldi Studi Medici Centro Studi di Ginecologia, Fertilità e Parto; IRI Centro Ricerche Medicina della Riproduzione; Machiavelli Medical House; Medicina e Biologia della Riproduzione European Hospital; Nuova Villa Claudia Centro di Procreazione Medicalmente Assistita; One Day Medical Center s.r.l. (Ex Biogenesi); Praxi ProVita Centro di Fertilità; Servizio Fisiopatologia della Riproduzione e Fecondazione ASL RM A Centro della Salute della Donna S. Anna; Unità Operativa Fisiopatologia Riproduzione e Terapia Infertilità Ospedale Sandro Pertini ASL RM B; UOC OG C03 Infertilità e Fivet Azienda Policlinico Umberto I Università Sapienza Rozzano: I.R.C.C.S. Istituto Clinico Humanitas Dipartimento di Ginecologia e Medicina della Riproduzione Salerno: C.M.R. s.r.l. Centro di Medicina della Riproduzione; Fertilitas M.R.D.S. (Medicina della Riproduzione Day Surgery) s.r.l.; GEA Medicina della Riproduzione del Dott. Mario Cirmeni; Mediterraneo Medicina della Riproduzione Sassari: Centro per PMA Clinica Ostetrica e Ginecologica dell Università di Sassari A.O.U. di Sassari Selvazzano Dentro: Poliambulatorio Tencarola Arcella Analisi Mediche Biolab srl Siena: Centro Diagnosi e Cura Sterilità Università degli Studi di Siena U.O. Ostetricia e Ginecologia Policlinico Le Scotte-P.O. Senese Sondrio: Centro Sterilità della Coppia U.O. Ostetricia e Ginecologia A.O. della Valtellina e della Valchiavenna Ospedale Civile di Sondrio Sora: Centro S.T.S. s.r.l. Ambulatorio Fisiopatologia della Riproduzione Ginecologia ed Endocrinologia Taranto: CREA S.R.L. Centro Riproduzione e Andrologia Torino: C. M. R. Centro di Medicina Riproduttiva e Procreazione Assistita; Centro Medicina della Riproduzione Dipt. Disciplina Ginec. E Ostetriche Univ. Degli Studi di Torino; Centro Clinico San Carlo di Fecondazione Assistita e Ginecologia; Centro di Fisiopatologia della Riproduzione Ospedale Maria Vittoria ; Ginecologia Endocrinologica Centro FIVER Torino Ospedale Sant Anna; Livet s.r.l.; Promea s.p.a Trecenta: Centro PMA Presidio Ospedaliero S. Luca Trecenta ULSS 18 di Rovigo Treviso: Salute e Cultura Trieste: SSD Procreazione Medicalmente Assistita IRCCS Burlo Garofalo Udine: Casa di Cura Città di Udine Umbertide: Studio Associato Ostetrico-Ginecologico e Medicina della Riproduzione G.en.e.r.a Umbertide Vallo Della Luciana: Centro di PMA U.O. Ostetricia e Ginecologia P.O. San Luca di Vallo della Lucania Varese: Centro di Procreazione Medico Assistita U.O. Ostetricia e Ginecologia A.O. Ospedale Circolo e Fondazione Macchi di Varese P.O. Filippo del Ponte Venezia: ARC STER Centro Studi per la Terapia della Sterilità della Coppia s.r.l.; Centro di Procreazione Medicalmente Assistita P.O.di Mestre U.O. Ostetricia e Ginecologia Azienda U.L.S.S. 12 Venezia; Venice Fertility Verona: Centro Athena; Centro per la Diagnosi e Cura della Sterilità di Coppia- Ospedale Policlinico G.B Rossi Borgo Roma; Studio Medico Tethys Viareggio: Centro di Riproduzione Assistita Ettore Barale U.O.C. Ostetricia e Ginecologia Ospedale Versilia USL 12 di Viareggio Vicenza: Centro Medico Palladio

9 Vignola: San Tommaso Day Surgery Villorba: Centro do Medicina S.p.A Kazakhtstan Almaty: IVF Almaty Center; National Institute Obstetrics and Gynecology; Centre for Human Reproduction Astana Ekolife Lithuania Vilnius: Baltic and American Clinic Macedonia Bitola: Private IVF Center PLODNOST Skopje: University Gyn-Ob Clinic, Medical faculty Skopje; Special Gyn-Ob Hospital SISTINA ; General Hospital REMEDICA Moldova Chisinau: National Center for Reproductive Health and Medical Genetics Montenegro Podgorica: LIFE, private clinic Podgorica: ARS MEDICA, private clinic Cetinje: Human Reproduction Department, Hospital Danilo I Cetinje, governmental centre for ART Norway Bergen: Haukeland Universitetssykehus Haugesund: Haugesund Sykehus HF; Klinikk Hauskens Porsgrunn: Sykehuset Telemark HF Tromsø: Universtitetssykehus Nord Norge Trondheim: Medicus; St Olavs Hospital Oslo: Aleris; Rikshospitalet; Ulleval Universitetssykehus; Volvat Medical senter Poland Bialystok: BOCIAN Centrum Położniczo-Ginekologiczne; Klinika Rozrodczości i Endokrynologii Ginekologicznej; KRIOBANK Małżeńskiej; ARTemida Domitrz i Partnerzy. Bydgoszcz: GENESIS NZOZ Centrum Medyczne Gdansk: Invicta Klinika Leczenia Niepłodności Gdynia: GAMETA Katowice: ANGELIUS Szpital PROVITA; Zięba Clinic NZOZ; GYNCENTRUM Kielce: GAMETA Kraków: ARTVIMED; MACIERZYŃSTWO Centrum Medyczne; PARENS Centrum Leczenia Niepłodności Lodz: GRAVITA Diagnostyka i Leczenie Niepłodności; SALVE-MEDICA Lublin: AB OVO Sp. z o.o. NZOZ Centrum Zdrowia Rodziny; OVUM Rozrodczość i Andrologia Sp. z o.o Myslowice: NOVOMEDICA Opole: GMW EMBRIO Sp. z o.o Plock: GRAVIDA Police: Klinika Medycyny Rozrodu i Ginekologii; Poznan: Klinika Niepłodności i Endokrynologii Rozrodu; MedART Rzeszów: PARENS Rzgow: GAMETA Szpital Rzgow Szczecin: VitroLive Warszawa: INVICTA Klinika Leczenia Niepłodności; INVIMED Europejskie Centrum Macierzyństwa; novum Przychodnia Lekarska; Ośrodek Diagnostyki i Leczenia Niepłodności Wroclaw: POLMEDIS Klinika Leczenia Niepłodności; INVIMED Portugal Braga: FERTICARE Coimbra: FERTICENTRO; Hospitais da Universidade de Coimbra; Clinimer Espinho: COGE Faro: Fertimed Guimarães: Centro Hospitalar do Alto Ave Hospital N. S. da Oliveira Lisboa: Ava Clinic; British Hospital; CEMEARE; CLINDIGO; Centro Hospitalar Lisboa Norte Hospital de Santa Maria; CLIFER; Imoclinica; IVI-Lisboa; Maternidade Dr Alfredo da Costa; Hospital dos Lusiadas Oporto: Centro de Genética Prof. Alberto Barros; CEIE; CETI; Hospital de Santo António; Hospital de S. João; Maternidade Júlio Dinis Ponta Delgada: Clínica do Bom Jesus Vila Nova de Gaia: Centro Hospitalar Russia Astrakhan: Center for Family Planning and Reproduction Barnaul: Siberian institute of human reproduction and genetics Belgorod: Regional Clinical Hospital of Saint Ioasaph Blagoveshchensk: Clinic AmurMed Bryansk: Regional Center of a Family Planning and Human Reproduction Cheboksary: State-financed organization Presidential Perinatal Center of the Ministry of Health and Social Development of the Chuvash Republic Chelabinsk: Verlinsky Research Institute of Reproductive Medicine; DNK Clinic; Center for family planning and reproduction. Ekaterinburg: Center for Treatment of Reproductive Function Disorders Partus ; Ural Research Institute of Maternity and Child Care Ivanovo: Research Institute of Maternity and Childhood n.a. V.N. Gorodkov Kazan: AVA-PETER Ltd Kazansky department; Private clinic Nuriev s clinic Kislovodsk: Clinic Elorma Khabarovsk: State Common Health Institution Perinatal Center Khanty-Mansiysk: Establishment of Khanty-Mansiysk autonomous okrug Yugra Clinical hospital of okrug Krasnodar: The Municipal Health Care Institution The Planned Parenthood and Reproductive Health Center Krasnoyarsk: Center for Reproductive Medicine; Medical center of gynecologic endocrinology and reproduction Three hearts Makhachkala: Dagestan Centre of Human Reproduction Moscow: Scientific center for obstetrics Gynecology and Perinatology n.a. V.I.Kulakov; Perinatal medical center, IVF Department; Medical Center of Assisted Reproductive Technologies; Medical Center Lera ;

10 MAMA fertility Clinic; ART Clinic Test-Tube Babies ; Medical Center for Infertility Treatment Embrion ; Clinic and hospital Moscvorechye ; Moscow Centre of Andrology and Reproductive Gynecology; Infertility Treatment Clinic Mother & Child ; Medical Centre ART-EKO ; IVF and Genetics Center FertiMed ; EURO-CLINIC; Medical Center ASKON ; Endocrinology Research Center; Gynecology Department with the use of ART of the Central Clinical Hospital Nizhny Novgorod: Clinic AIST NN ; Federal Budget Health Care Institution Volga district health center of the Federal Medical-Biological Agency Novokuzneck: Clinic Media-Service ; Clinic of Women Health and Reproduction MEDICA ; Zonal Perinatal Center Novosibirsk: Medical Center Avicenna Omsk: The First Clinical Maternity Hospital of Omsk Oblast; Centre of Reproductive Medicine Orenburg: Center of Family Planning and Reproduction; Clinic MaxiMed Rostov-Don: Center of Human Reproduction and IVF Samara: IDK Medical Company; Clinic of Reproductive Health IVF ; Clinical Center of Cells Technologies Saratov: Regional Center for Family Planning and Reproduction; Clinic of Doctor Paramonov St. Petersburg: International Center for Reproductive Medicine; Saint- Petersburg State Establishment of Health Protection Maternity welfare clinic ~44 of Pushkinskiy District, Reproduction and Family Planning Center; AVA-PETER Ltd; Baltic Institute of Human Reproductology; Aimed Ltd; Mariinsky Hospital, Assisted Reproductive Technology Department; Advanced Fertility Clinic; Almazov Federal Heart, Blood and Endocrinology Centre; Euromed-Clinic Stavropol: Medical Diagnosis Stavropol Regional Centre Syktyvkar: Komi Republik Perinatal Centre Tula: Center of New Medical Technology Tumen: International Medical Center for Reproduction Mercury ; Medical Center Malysh. Ufa: Republic Center of Perinatology; ANEKO Medical Center Family Vladikavkaz: Republic Center for Family Planning and Reproduction Vladivostok: Medical Center for IVF and Endoscopic Surgery in Gynecology Santa Maria Yakutsk: Republic Hospital N1 National Centre of Medicine, Consultation of Human Reproduction Serbia Belgrade: Klinika za ginekologiju i akušerstvo Klinički Centar Srbije; Klinika za ginekologiju i akušertsvo Narodni front ; Specijalna ginekološka bolnica za lečenje steriliteta Jevremova ; Specijalna ginekološka bolnica za lečenje steriliteta Beograd ; Specijalna ginekološka bolnica Ivanović ; Specijalna bolnica za lečenje steriliteta Intermedicus BIS Medijana: Klinika za ginekologiju i akušerstvo, Klinički Centar Niš Novi Sad: Klinika za ginekologiju i akušerstvo, Klinički centar Vojvodine; Specijalna ginekološka bolnica Genesis Slovenia Ljubljana: Univerzitetni klinični center Ljubljana Maribor: Klinika za ginekologijo in perinatologijo,ukc Maribor Postojna: Bolnišnica za ginekologijo in porodništvo Spain A Coruña: Maternidad Belén Alava: Hospital de Txagorritxu Albacete: Hospital General de Albacete Alicante: Hospital General de Alicante; Hospital Inernacional Medimar; Centro Ginecológic Manjón; IVI Alicante Almeria: Unidad de Reproducción Hospital Virgen del Mar; Cira Mediterráneo; Roquetas FIV; Clinica JOFRE-FIV; IVI Almeria; URC H. Torrecárdenas Asturias: HUCA Unidad de Reproducción Hospital Materno Infantil Badajoz: Complejo Hospitalario Infanta Cristina (CERHA) Baleares: Instituto Balear de Fertilidad (IBI); Hospital Universitario Son Dureta; Hospital Son Llatzer; Hospital de Manacor; Instituto de Fertilidad Ana Belén Castel Barcelona: Institut Dexeus; IVI Barcelona; Hospital Clínic de Barcelona; Instituto Pous; Centro MédicoTeknon; Fertilab; Gine-3; ESIMER; FECUNMED; IMARA Hospital de Sant Pau; Hospital Vall d Hebron; Centro de Reproducción Asistida Sagrada Familia; Instituto de Ginecologia y Reproducción de Barcelona; Consorci Sanitari Parc Tauli Sabadell; Hospital Quiron Barcelona; Hospital del Mar; Centre Médic Salus XXI Caceres: Clínica Norba; Hospital Ciudad de Coria Cadiz: Clínica Medrano; Clinica SERMAN; FIV Recoletos Cádiz; Grupo Médico de Reproducción GMER; Unidad de Reproducción Área Sanitaria Campo de Gibraltar. FIV Recoletos Jerez Cantabria: Hospital Marqués de Valdecilla; CER Santander Castellón: IVI Castellón; H General de Castellón Ciudad Real: Clínica Rubal; FIV Recoletos Ciudad Real Cordoba: Clinica BAU; H.U. Reina Sofia Gipuzkoa: Clínica El Pilar de San Sebastián Girona: GINEXX, Unitat Reproduccio Humana Clínica Girona Gran Canaria: H.U. Materno Infantil de Las Palmas de Gran Canaria Granada: Hospital Virgen de las Nieves; Clínica Sanabria; CRH Granada; Margen S.L Guadalajara: FIV Recoletos Guadalajara Huelva: Fertimed Huelva; Unidad de Reproducción del H Juan Ramón Jiménez Jaen: Clínica Avicena; Clínica Ciudad de Jaén La Rioja: Clínica Ginecológica Juana Hernández; Hospital San Pedro; Centro Ginecológico Riojano Madrid: FIV Center; GINEFIV Madrid; Clínica Tambre; IVI Madrid; U.R.H García del Real; Hospital Severo Ochoa; Unidad de Reproducción Hospital de Alcorcón; Hospital La Paz; IGMR Dres. Ordás y Palomo; FIV Recoletos Madrid; Instituto Para El Estudio De La Esterilidad; Fundación Jiménez Díaz; Hospital Universitario Madrid-Montepríncipe; Hospital Quirón Madrid; Hospital Clínico San Carlo; Clínica Ruber Internacional; Hospital G Universitario Gregorio Marañón; Instituto Europeo de Infertilidad; Hospital Príncipe de Asturias; Clínica Procreatec; Hospital Ramón y Cajal Malaga: Málaga FIV; Centro Gutemberg; Hospital Materno-Infantil Carlos Haya; Clínica FERTIA; Clínica Rincón; CERAM (Centro de Reproducción Asistida de Marbella); CEMAR (Centro Malagueño de Reproducción Asistida); Consulta Jesús García; Hospital Costa del Sol Murcia: Tahe Fertilidad; Clínica IMAR (I Mediterránea Asociados en Reproducción); Hospital Universitario Virgen de la Arrixaca; IVI Murcia Navarra: Unidad de Reproducción del Hospital Virgen del Camino

11 Ourense: Complexo Hospitalario de Ourense Pontevedra: Hospital Nuestra Señora de Fátima; Povisa, Centro Hospitalario Universitario de Vigo Sevilla: Ginemed; Hospital Universitario Virgen del Rocío; CIVTE; CARE Clínica Ginecológica; Instituto Génesis; IVI Sevilla; Hospital Universitario Virgen de Valme Tarragona: Embriogyn Toledo: Hospital Virgen de la Salud Valencia: Hospital Universitario La Fe; IVI Valencia; HGU de Valencia Unidad de Reproducción Humana; Clínica Quirón Valencia; Hospital Francesc de Borja; Policlínico de Valencia; IMER Valladolid: FIV Recoletos; Hospital Clínico Universitario de Valladolid Vizcaya: Clínica Ginecológica Bilbao; Clínica Euskalduna; Quirón Bilbao; Hospital de Cruces; Galdakao Usansolo Ospitalea Zaragoza: Hospital Miguel Servet; URAM de la Clínica Montpellier Sweden Falun: IVF unit, Falu Hospital Göteborg: Fertility Center, Carlanderska Hospital; Reproduktionsmedicin, Sahlgrenska University Hospital, Göteborgs kvinnoklinik Linköping: IVF unit, RMC, Linköping University Hospital Malmö: Curakliniken; Öresundskliniken; RMC, Malmö University Hospital Örebro: IVF unit, Örebro University Hospital Stockholm: IVF Stockholm, St Görans Hospital; IVF unit, Karolinska University Hospital Huddinge; IVF unit, Sophiahemmet; Fertility Center Stockholm Umeå: IVF unit, Norrlands University Hospital, Umeå Uppsala: Carl von Linné Kliniken; Reproductive Center, Academic Hospital Switzerland Baden: Kinderwunschzentrum Baden, Frauenklinik Basel: Universitäts-Frauenklinik Basel; Kinderwunschzentrum Regio Basel; Fertilitas Bellinzona: Endomed Bern: Kinderwunschzentrum, Universitätsfrauenklinik; IVF-Team Lindenhofspital Biel: Care Genève: Centre Privé de PMA, Clinique des Grangettes; Unité de la médecine de la reproduction et d endocrinologie, HCUG; Centre PMA Clinique Générale Beaulieu-UNILABS Lausanne: Unité de Médecine de la Reproduction et d Endocrinologie gynécologique CHUV; Centre de PMA Clinique de la Source; Viollier- Medixy; Centre de procréation médicalement assistée (CPMA) Locarno: Centro Cantonale di Fertilità Luzern: Kinderwunschzentrum Luzern, Frauenklinik Niederuzwil: Institut für Reproduktionsmedizin und Endokrinologie Schaffhausen: Zentrum für Reproduktionsmedizin Sorengo: IIRM (Istituto Internazionale di medicina della riproduzione) St Gallen: Fachinstitut der Ostschweiz für Reproduktionsmedizin und Gynäkologische Endokrinologie (FIORE) Winterthur: Sterilitätszentrum Wintherthur Zürich: IVF Zürich; Universitätsspital Zürich, Kinderwunsch-Zentrum; GYN-A.R.T. AG The Netherlands Amsterdam: Academisch Medisch Centrum; Vrije universiteit Medisch Centrum Eindhoven: Catharina Ziekenhuis Groningen: Universitair Medisch Centrum Groningen Leiden: Leids Universitair Medisch Centrum Leiderdorp: MCK Maastricht: Universitair Medisch Centrum Maastricht Nijmegen: Universitair Medisch Centrum Nijmegen Rotterdam: Erasmus Medical Centre Tilburg: St. Elisabeth Ziekenhuis Utrecht: Universitair Medisch Centrum Utrecht Voorburg: Reiner de Graaf Groep Zwolle: Isala Ukraine Chernivtsi: Medical centre of infertility treatment Dnipropetrovs k: Genesis-Dnepr-IVF Donetsk: Isida-Don-IVF; Ukranian French medical Centre of Human Reproductive Function; Donetsk Regional Centre for Maternity and Child Care Ivano-Frankivs k: Precarpacian Centre of Reproductive Medicine Kharkyv: Ltd Sana-med; Center of Human Reproduction Implant Kyiv: Clinic of Reproductive Medicine Nadija; Institute of Reproductive Medicine; Neomed; Lviv: IVF clinic Alternatyva Odessa: Center for Reproductive Medicine REMEDI; LADA Reproductive Health Clinic; Reproductive Medicine Department, University Clinic, Odessa National Medical University Simferopol: Clinic of Crimean State Medical University; Department for Reproductive Medicine Genesis Clinic The UK Aberdeen: Aberdeen Fertility Centre Aldridge: Midland Fertility Services Bath: Bath Fertility Centre Belfast: Origin Fertility Care; Regional Fertility Centre, Belfast Birmingham: Birmingham Women s Hospital; BMI Priory Hospital Brentwood: Brentwood Fertility Centre Brighton and Hove: The Agora Gynaecology and Fertility Centre Bristol: Bristol Centre for Reproductive Medicine Burton Upon Trent: Burton Hospitals NHS Trust Cambridge: Bourn Hall Clinic Canterbury: BMI The Chaucer Hospital Cardiff: IVF Wales; London Women s Clinic, Cardiff Cheshunt: Herts and Essex Fertility Centre Colchester: Bourn Hall Clinic (Colchester) Coventry: Centre for Reproductive Medicine, Coventry Cranbrook: Benenden Fertility Centre (BFC) Darlington: London Women s Clinic, Darlington Dorchester: The Winterbourne Hospital Dundee: Ninewells Hospital Eastbourne: Sussex Downs Fertility Centre Edinburgh: Edinburgh Assisted Conception Unit; IVF Scotland 1200

12 Exeter: Peninsular Centre for Reproductive Medicine Gateshead: The Gateshead Fertility Unit Glasgow: Glasgow Nuffield Hospital; Glasgow Royal Infirmary; Glasgow Centre for Reproductive Medicine Great Missenden: The Chiltern Hospital Fertility Services Unit Hartlepool: Assisted Reproduction Unit (ARU), University Hospital of Hartlepool Hull: Hull IVF Unit Leeds: The Leeds Centre for Reproductive Medicine Leicester: Leicester Fertility Centre Liverpool: Hewitt Fertility Centre Llantrisant: Centre for Reproduction and Gynaecology Wales (CRGW) London: Assisted Conception Unit, King s College Hospital; Assisted Reproduction and Gynaecology Centre; Barts and The London Centre for Reproductive Medicine; Chelsea and Westminster Hospital; CREATE Centre for Reproduction and Advanced Technology; CRM London; Guys Hospital; Homerton Fertility Centre; IVF Hammersmith; London Female and Male Fertility Centre; London Fertility Centre; London Women s Clinic; Reproductive Genetics Institute; The Bridge Centre; The Centre for Reproductive and Genetic Health; The Lister Fertility Clinic. Manchester: CARE Manchester; Manchester Fertility Services LTD; St Mary s Hospital Middlesbrough: The James Cook University Hospital Newcastle Upon Tyne: Newcastle Fertility Centre at Life Northampton: CARE Northampton Nottingham: CARE Nottingham; NURTURE. Orpington: BMI Chelsfield Park ACU Oxford: Oxford Fertility Unit Plymouth: South West Centre for Reproductive Medicine Salisbury: Salisbury Fertility Centre Sheffield: CARE Sheffield; Jessop Fertility Shrewsbury: Shropshire and Mid-Wales Fertility Centre Southampton: Wessex Fertility Limited Swansea: London Women s Clinic, Swansea Tunbridge Wells: South East Fertility Clinic Woking: Nuffield Health Woking Hospital Wolverhampton: St Jude s Women s Hospital

13 Supplementary Table SI Participants of the EIM Consortium. Country 2010 2009 2008 2007 2006 Members of the European Union European countries... Albania x x x x Andorra x Armenia x Austria x x x x x x Azerbaijan x Belarus x Belgium x x x x x x x Bosnia x x x x Bulgaria x x x x x x Croatia x x x Cyprus x x x x x Czech Republic x x x x x x x Denmark x x x x x x x Estonia x x x Finland x x x x x x x France x x x x x x x Georgia x Germany x x x x x x x Greece x x x x x x x Hungary x x x x x x x Iceland x x x x x x Ireland x x x x x x Italy x x x x x x x Kazakhtstan x x x x Kosovo x Latvia x x x x x x Liechtenstein x Lithuania x x x x x x x Luxemburg x x Macedonia x x x x x x Malta x x Moldova x x x x Monaco x Montenegro x x x x x x Norway x x x x x x Poland x x x x x x x Portugal x x x x x x x Romania x x x x x Russia x x x x x x San Marino x Serbia x x x x x x Slovakia x x Slovenia x x x x x x x Spain x x x x x x x Sweden x x x x x x x Switzerland x x x x x x The Netherlands x x x x x x x Continued

14 Supplementary Table SI Continued Country 2010 2009 2008 2007 2006 Members of the European Union European countries... Turkey x x x x TheUK x x x x x x x Ukraine x x x x x x Vatican City x Black shaded, no data received; grey shaded, not a member. Supplementary Table SII Size of the IVF clinics reporting to the register in 2010. Country IVF clinics in the Size of reporting clinics (cycles per year) country...... All Reporting <100 % 100 199 % 200 499 % 500 999 % 1000 %... Austria 29 29 6 20.7 13 44.8 8 27.6 1 3.4 1 3.4 Belgium 18 18 0 0.0 0 0.0 2 11.1 4 22.2 12 66.7 Bulgaria 21 7 1 14.3 2 28.6 2 28.6 1 14.3 1 14.3 Czech Republic 32 32 4 12.5 0 0.0 8 25.0 13 40.,6 7 21.9 Denmark 20 20 1 5.0 0 0.0 4 20.0 9 45.,0 6 30.0 Finland 18 18 0 0.0 4 22.2 7 38.9 6 33.,3 1 5.6 France 107 104 5 4.8 9 8.7 34 32.7 37 35.6 19 18.3 Germany 124 114 12 10.5 12 10.5 39 34.2 29 25.4 22 19.3 Greece 50 9 0 0.0 4 44.4 3 33.3 2 22.2 0 0.0 Hungary 12 12 1 8.3 0 0.0 5 41.7 5 41.7 1 8.3 Iceland 1 1 0 0.0 0 0.0 0 0.0 1 100.0 0 0.0 Ireland 7 6 0 0.0 1 16.7 1 16.7 3 50.0 1 16.7 Italy 202 202 68 33.7 46 22.8 53 26.2 24 11.9 11 5.4 Kazakhstan 10 3 1 33.3 0 0.0 1 33.3 0 0.0 1 33.3 Lithuania 4 1 0 0.0 1 100.0 0 0.0 0 0.0 0 0.0 Macedonia 4 4 0 0.0 0 0.0 2 50.0 2 50.0 0 0.0 Moldova 2 1 0 0.0 0 0.0 0 0.0 1 100.0 0 0.0 Montenegro 3 3 1 33.3 1 33.3 1 33.3 0 0.0 0 0.0 Norway 11 11 0 0.0 0 0.0 3 27.3 4 36.4 4 36.4 Poland 38 29 10 34.5 2 6.9 10 34.5 6 20.7 1 3.4 Portugal 25 25 6 24.0 4 16.0 12 48.0 3 12.0 0 0.0 Romania 13 10 5 50.0 4 40.0 1 10.0 0 0.,0 0 0.0 Russia 116 72 13 18.1 10 13.9 26 36.1 18 25.0 5 6.9 Serbia 14 10 0 0.0 2 20.0 8 80.0 0 0.0 0 0.0 Slovenia 3 3 0 0.0 0 0.0 0 0.0 1 33.3 2 66.7 Spain 160 103 14 13.6 22 21.4 31 30.1 24 23.3 12 11.7 Sweden 16 16 0 0.0 0 0.0 1 6.3 9 56.3 6 37.5 Switzerland 26 25 5 20.0 2 8.0 13 52.0 3 12.0 2 8.0 The Netherlands 13 13 0 0.0 0 0.0 1 7.7 5 38.5 7 53.8 Ukraine 31 18 3 16.7 4 22.2 6 33.3 3 16.7 2 11.1 The UK 72 72 5 6.9 1 1.4 19 26.4 29 40.3 18 25.0 All 1202 991 161 16.2 144 14.5 301 30.4 243 24.5 142 14.3

15 Supplementary Table SIII Reporting methods in all countries reporting to the EIM in 2010. Country Requirements Responsibility Reporting methods... Cycles Deliveries... All reporting Austria Compulsory National Health Authority Individual Individual Belgium Compulsory National Health Authority Individual Individual Czech Republic Compulsory National Health Authority Individual Individual Denmark Voluntary Medical Organization Summaries Summaries Finland Compulsory National Health Authority Summaries Summaries Hungary Compulsory National Health Authority Individual Individual Iceland Compulsory Medical Organization Summaries Summaries Italy Compulsory National Health Authority Summaries Summaries Macedonia Voluntary National Health Authority Summaries Summaries Montenegro Compulsory Medical Organization Summaries Summaries Norway Compulsory National Health Authority Summaries Summaries Portugal Compulsory National Health Authority Summaries Summaries Slovenia Compulsory National Health Authority Summaries Summaries Sweden Compulsory Medical Organization Individual Individual The Netherlands Compulsory National Health Authority Individual Individual The UK Compulsory National Health Authority Individual Individual Partially reporting Bulgaria Voluntary Personal initiative Summaries Summaries France Compulsory National Health Authority Summaries Summaries Germany Voluntary Medical Organization Individual Individual Greece Voluntary National Health Authority Summaries Summaries Ireland Voluntary Medical Organization Summaries Summaries Kazakhstan Voluntary Medical Organization Summaries Summaries Lithuania Voluntary Personal initiative Individual Individual Moldova Voluntary Medical Organization Summaries Summaries Poland Voluntary Medical Organization Summaries Summaries Romania Voluntary Medical Organization Summaries Summaries Russia Voluntary Medical Organization Summaries Summaries Serbia Compulsory Medical Organization Summaries Summaries Spain Voluntary Medical Organization Summaries Summaries Switzerland Voluntary Medical Organization Individual Individual Ukraine Voluntary Medical Organization Summaries Summaries Reporting: individual ¼ individual cycles/pregnancy forms; summaries ¼ annual summaries of activities.

16 Supplementary Table SIV Countries where all clinics reported to the national register in 2010. Country Cycles Population Females of Cycles/ Cycles/million ART ART National ART reproductive million females of deliveries infants births infants age (millions) reproductive age (%)... Austria 6402 8.2 1.6 779 3939 1253 1559 78 742 2.0 Belgium 28 521 10.4 2.0 2736 14 494 4649 5199 129 173 4.0 Czech Republic 20 020 10.2 2.1 1962 9380 117 446 Denmark 15 954 5.5 0.9 2893 17 669 3205 3724 63 487 5.9 Finland 9312 5.3 1.0 1772 9719 1781 1859 61 371 3.0 Hungary 5562 10 2.0 557 2703 90 335 Iceland 824 0.3 0.1 2594 12 656 193 216 4903 4.4 Italy 58 860 60.7 11.9 969 4949 7942 9794 561 944 1.7 Macedonia 1497 2.1 0.5 722 3288 451 611 Montenegro 452 0.7 0.1 678 3183 104 136 7690 1.8 Norway 9007 4.7 0.9 1926 10 089 1885 2098 51 442 4.1 Portugal 7179 10.7 2.2 669 3290 1616 1962 101 381 1.9 Slovenia 4419 2 0.4 2206 17 701 987 1131 22 343 5.1 Sweden 17 628 9.1 1.5 1942 11 990 3809 4025 114 971 3.5 The Netherlands 23 627 16.6 3.2 1426 7394 4584 5015 184 397 2.7 The UK 57 856 62.3 12.3 928 4693 14 188 17 014 791 312 2.2 All 267 120 219 42.7 1221 6258 46 647 54 343 2 380 937 ARTcyclesreferto IVF, ICSI, FER, ED, IVM, FORandPGD combined. 798deliveriesafterIVMand FORwereexcludedfromthe calculations; totalsrefertothesecountries wheredatawere reported. Females of reproductive age refer to women between 15 and 45 years old (http://www.census.gov/ipc/www/idb/country.php). For the calculation of the cycles/million females of reproductive age, the original numbers (as found in Table I) are used, not the abbreviated numbers as mentioned in this table.

Supplementary Table SV Pregnancies and deliveries after IVF in 2010. Country Cycles Aspirations Transfers Clinical Deliveries Pregnancies Pregnancies Pregnancies Deliveries Deliveries Deliveries pregnancies per cycle (%) per aspiration (%) per transfer (%) per cycle (%) per aspiration (%) per transfer (%)... Austria 1014 952 330 32.5 34.7 Belgium 4526 4052 1213 887 26.8 29.9 19.6 21.9 Bulgaria 680 666 514 199 163 29.3 29.9 38.7 24.0 24.5 31.7 Czech Republic Denmark 6635 6304 5308 1584 1410 23.9 25.1 29.8 21.3 22.4 26.6 Finland 2632 2516 2202 781 630 29.7 31.0 35.5 23.9 25.0 28.6 France 21 783 18 084 5259 4047 24.1 29.1 18.6 22.4 Germany 9545 8876 2663 1825 27.9 30.0 19.1 20.6 Greece 823 710 657 239 197 29.0 33.7 36.4 23.9 27.7 30.0 Hungary 1217 1211 1171 393 32.3 32.5 33.6 Iceland 279 217 73 60 26.3 33.6 21.6 27.6 Ireland 1856 1483 1346 463 379 24.9 31.2 34.4 20.4 25.6 28.2 Italy 8797 7606 6425 1830 1265 20.8 24.1 28.5 14.4 16.6 19.7 Kazakhstan 1282 1282 1170 447 331 34.9 34.9 38.2 25.8 25.8 28.3 Lithuania 59 57 57 15 25.4 26.3 26.3 Macedonia 323 283 253 125 91 38.7 44.2 49.4 28.2 32.2 36.0 Moldova 284 272 260 104 86 36.6 38.2 40.0 30.3 31.6 33.1 Montenegro 29 27 25 13 13 44.8 48.1 52.0 44.8 48.1 52.0 Norway 3118 2942 2575 863 717 27.7 29.3 33.5 23.0 24.4 27.8 Poland 347 335 313 125 56 36.0 37.3 39.9 16.1 16.7 17.9 Portugal 1736 1571 1406 551 418 31.7 35.1 39.2 24.1 26.6 29.7 Romania 566 506 480 208 36.7 41.1 43.3 Russia 14 239 13 817 12 374 4722 3476 33.2 34.2 38.2 24.4 25.2 28.1 Serbia 419 410 351 129 98 30.8 31.5 36.8 23.4 23.9 27.9 Slovenia 1233 1205 1058 414 337 33.6 34.4 39.1 27.3 28.0 31.9 Spain 3456 2880 2474 974 503 28.2 33.8 39.4 14.6 17.5 20.3 Sweden 5754 5348 4724 1702 1312 29.6 31.8 36.0 22.8 24.5 27.8 Switzerland 799 741 605 159 124 19.9 21.5 26.3 15.5 16.7 20.5 The Netherlands 8750 7895 6925 2247 1683 25.7 28.5 32.4 19.2 21.3 24.3 Ukraine 2382 2328 2198 890 646 37.4 38.2 40.5 27.1 27.7 29.4 The UK 21 431 18 738 16 920 5788 5065 27.0 30.9 34.2 23.6 27.0 29.9 All* 88 847 118 280 103 972 34 503 25 819 28.1 29.2 33.2 21.8 22.4 25.5 The recording of deliveries is incomplete, see Supplementary data, Table SXIII. For Austria, Belgium, France, France, Germany and Iceland no data on initiated cycles available. Data on deliveries not available for Austria, Hungary, Lithuania and Romania. No data available for the Czech Republic. *Total refers to those countries where data were reported. 17

Supplementary Table SVI Pregnancies and deliveries after ICSI in 2010. 18 Country Cycles Aspirations Transfers Clinical Deliveries Pregnancies Pregnancies per Pregnancies per Deliveries Deliveries per Deliveries per pregnancies per cycle (%) aspiration (%) transfer (%) per cycle (%) aspiration (%) transfer (%)... Austria 4768 4476 1663 34.9 37.2 Belgium 13 131 11 830 3385 2345 25.8 28.6 17.9 19.8 Bulgaria 3993 3960 3210 1140 897 28.5 28.8 35.5 22.5 22.7 27.9 Czech Republic Denmark 5599 5417 4659 1389 1247 24.8 25.6 29.8 22.3 23.0 26.8 Finland 2229 2147 1921 597 475 26.8 27.8 31.1 21.3 22.1 24.7 France 34 709 32 001 9559 7511 27.5 29.9 21.6 23.5 Germany 35 150 33 904 9708 6692 27.6 28.6 19.0 19.7 Greece 1931 1703 1546 530 405 27.4 31.1 34.3 21.0 23.8 26.2 Hungary 3874 3863 3629 1169 30.2 30.3 32.2 Iceland 223 195 73 62 32.6 37.4 27.7 31.8 Ireland 1320 1173 1079 383 306 29.0 32.7 35.5 23.2 26.1 28.4 Italy 43 864 39 843 34 043 9154 6243 20.9 23.0 26.9 14.2 15.7 18.3 Kazakhstan 348 348 329 113 78 32.5 32.5 34.3 22.4 22.4 23.7 Lithuania 53 53 53 18 34.0 34.0 34.0 Macedonia 1086 1009 929 417 342 38.4 41.3 44.9 31.5 33.9 36.8 Moldova 340 328 315 130 110 38.2 39.6 41.3 32.4 33.5 34.9 Montenegro 417 417 389 118 89 28.3 28.3 30.3 21.3 21.3 22.9 Norway 3439 3314 2842 924 785 26.9 27.9 32.5 22.8 23.7 27.6 Poland 8621 8501 7473 2937 2233 34.1 34.5 39.3 25.9 26.3 29.9 Portugal 4139 3856 3346 1197 929 28.9 31.0 35.8 22.4 24.1 27.8 Romania 357 352 336 172 48.2 48.9 51.2 Russia 13 071 12 508 11 451 4233 2981 32.4 33.8 37.0 22.8 23.8 26.0 Serbia 1065 1050 965 372 289 34.9 35.4 38.5 27.1 27.5 29.9 Slovenia 2371 2310 1973 648 515 27.3 28.1 32.8 21.7 22.3 26.1 Spain 29 047 25 994 22 291 8513 5113 29.3 32.7 38.2 17.6 19.7 22.9 Sweden 5838 5499 4869 1719 1336 29.4 31.3 35.3 22.9 24.3 27.4 Switzerland 4683 4452 3709 1065 818 22.7 23.9 28.7 17.5 18.4 22.1 The Netherlands 8148 7639 6789 2426 1846 29.8 31.8 35.7 22.7 24.2 27.2 Ukraine 2882 2794 2613 1020 850 35.4 36.5 39.0 29.5 30.4 32.5 The UK 23 211 23 160 21 488 7228 6386 31.1 31.2 33.6 27.5 27.6 29.7 All* 171 926 249 671 224 653 72 000 50 883 27.7 28.8 32.0 20.4 21.1 23.5 The recording of deliveries is incomplete, see Supplementary data, Table SXIII. For Austria, Belgium, France, Germany and Iceland no data on initiated cycles available. For the Czech Republic, no data are available. Data on deliveries not available for Austria, Czech Republic, Hungary, Lithuania and Romania. *Total rates refer to those countries where data were reported.

19 Supplementary Table SVII Pregnancies and deliveries after FER (IVF and ICSI together) in 2010. Country Thawings Transfers Clinical Deliveries Pregnancies Pregnancies Deliveries per Deliveries per pregnancies per thawing (%) per transfer (%) thawing (%) transfer (%)... Austria 620 604 159 25.6 26.3 Belgium 8815 7138 1617 1094 18.3 22.7 12.4 15.3 Bulgaria 272 243 61 47 22.4 25.1 17.3 19.3 Czech Republic 4303 3963 Denmark 3371 2775 572 493 17.0 20.6 14.6 17.8 Finland 3280 815 588 24.8 17.9 France 21 376 18 750 3432 2477 16.1 18.3 11.6 13.2 Germany 17 876 16 947 3430 2150 19.2 20.2 12.0 12.7 Greece 461 442 129 98 28.0 29.2 21.3 22.2 Hungary 413 93 22.5 Iceland 205 200 60 49 29.3 30.0 23.9 24.5 Ireland 882 680 154 123 17.5 22.6 13.9 18.1 Italy 3758 3441 645 434 17.2 18.7 11.5 12.6 Kazakhstan 289 273 74 51 25.6 27.1 17.6 18.7 Lithuania 19 18 7 36.8 38.9 0.0 0.0 Macedonia 49 46 12 8 24.5 26.1 16.3 17.4 Moldova 0 0 0 0 Montenegro 6 6 2 2 33.3 33.3 33.3 33.3 Norway 2443 2046 486 383 19.9 23.8 15.7 18.7 Poland 3733 3550 866 549 23.2 24.4 14.7 15.5 Portugal 921 777 187 140 20.3 24.1 15.2 18.0 Romania 208 152 51 24.5 33.6 Russia 3760 3499 928 563 24.7 26.5 15.0 16.1 Serbia Slovenia 760 707 162 130 21.3 22.9 17.1 18.4 Spain 8760 7807 2448 1353 27.9 31.4 15.4 17.3 Sweden 5520 4948 1378 1051 25.0 27.8 19.0 21.2 Switzerland 4058 3668 777 544 19.1 21.2 13.4 14.8 The Netherlands 6729 1531 1055 22.8 15.7 Ukraine 1240 1177 334 251 26.9 28.4 20.2 21.3 The UK 10 476 9782 2297 2021 21.9 23.5 19.3 20.7 All* 104 181 104 061 22 707 15 654 20.3 22.7 14.1 15.8 The recording of deliveries is incomplete, see Supplementary data, Table SXIV. Data on the number of thawings are not available for Finland, Hungary and the Netherlands. For Austria, Hungary, Lithuania, Romania and the Netherlands no data on deliveries available. For the Czech Republic, no data on pregnancies and deliveries are available. For Serbia, no data are available. *Total rates refer to those countries where data were reported.

Supplementary Table SVIII Pregnancies and deliveries after egg donation (ED, fresh and frozen cycles) in 2010. 20 Country Donation Aspirations, Aspirations, Transfers, Transfers, Pregnancies, Pregnancies, Pregnancies/ Pregnancies/ Deliveries, Deliveries/ Deliveries/ fresh frozen fresh thawed fresh thawed fresh ET (%) thawed ET (%) fresh 1 frozen donation (%) ET (%)... Austria Belgium 1412 826 495 719 427 202 73 28.1 17.1 166 11.8 14.5 Bulgaria 76 75 1 75 11 37 7 49.3 63.6 35 46.1 40.7 Czech 2365 2278 2447 Republic Denmark 225 225 184 52 28.3 40 17.8 21.7 Finland 370 365 341 393 111 97 32.6 24.7 159 43.0 21.7 France 684 295 570 262 170 51 29.8 19.5 169 20.3 Germany Greece 446 242 188 263 172 109 59 41.4 34.3 122 27.4 28.0 Hungary 44 27 35 18 51.4 Iceland 65 52 48 51 16 14 33.3 27.5 22 22.2 Ireland 20 14 13 8 61.5 7 35.0 53.8 Italy Kazakhstan 229 228 69 200 69 106 18 53.0 26.1 86 37.6 32.0 Lithuania Macedonia 29 21 8 18 8 10 4 55.6 50.0 10 34.5 38.5 Moldova Montenegro Norway Poland 248 231 12 336 12 144 6 42.9 50.0 114 46.0 32.8 Portugal 282 234 312 150 48.1 113 40.1 36.2 Romania 20 20 20 10 50.0 Russia 2147 1586 505 1549 455 746 154 48.2 33.8 672 31.3 33.5 Serbia Slovenia 16 8 8 0 8 0 2 25.0 2 12.5 25.0 Spain 8615 6808 4313 7187 4032 3891 1512 54.1 37.5 3425 39.8 30.5 Sweden 171 186 148 64 39 34.4 26.4 84 25.1 Switzerland The Netherlands Ukraine 524 358 166 359 160 172 59 47.9 36.9 198 37.8 38.2 The UK 1562 1530 329 1430 304 552 72 38.6 23.7 549 35.1 31.7 All* 18 630 15 825 6612 16 292 6512 6568 2167 47.4 33.3 5973 35.1 29.4 No data available for Austria, Czech Republic, Germany, Italy, Lithuania, Moldova, Montenegro, Norway, Serbia, Switzerland and the Netherlands. *Total rates refer to those countries where data were reported. The recording of deliveries is incomplete, see Supplementary data, Table SXVI.

21 Supplementary Table SIX Initiated cycles, pregnancy and delivery rates by age distribution (years) of women treated with IVF in 2010. Country Cycles (%)... Pregnancy rates (%)... Delivery rates (%)... 34 35 39 40 34 35 39 40 34 35 39 40... Austria NA NA NA NA NA NA NA NA NA Belgium NA NA NA NA NA NA NA NA NA Bulgaria 54.6 35.1 10.3 38.5 19.7 12.9 33.7 14.2 5.7 Czech Republic 51.7 40.0 8.3 35.2 18.2 8.9 14.7 7.0 1.9 Denmark 42.7 33.6 23.7 NA NA NA NA NA NA Finland 50.9 33.2 15.9 37.1 28.9 16.0 31.8 22.1 9.5 France 48.9 35.2 15.9 NA NA NA NA NA NA Germany 41.1 38.2 20.7 34.7 27.4 15.4 24.8 17.8 8.5 Greece 35.1 35.4 29.5 39.4 30.3 17.3 32.6 26.1 13.1 Hungary 51.3 34.7 14.1 37.2 30.8 18.1 NA NA NA Iceland 44.1 35.1 20.8 31.7 27.6 13.8 27.6 22.4 8.6 Ireland 26.7 47.0 26.3 29.2 26.8 16.8 26.2 22.1 11.3 Italy 30.3 40.9 28.8 25.5 23.5 12.1 18.4 16.9 6.6 Kazakhstan 58.4 33.8 7.8 39.3 29.6 25.0 31.5 20.3 7.0 Lithuania 50.9 28.1 21.1 27.6 43.8 0.0 NA NA NA Macedonia 53.9 28.8 17.3 55.2 23.7 12.5 41.4 18.3 3.6 Moldova 60.6 29.6 9.9 40.7 32.1 25.0 34.3 27.4 14.3 Montenegro 69.0 27.6 3.4 60.0 12.5 0.0 60.0 12.5 0.0 Norway 49.1 39.5 11.4 31.0 26.5 17.2 27.0 21.4 11.3 Poland 63.4 30.3 6.3 40.5 31.4 13.6 16.8 16.2 9.1 Portugal 48.4 40.7 10.9 38.1 28.5 15.8 31.2 19.4 10.0 Romania 55.0 36.1 8.9 49.0 39.5 57.5 NA NA NA Russia 56.8 31.6 11.6 38.5 32.1 17.0 29.4 22.5 10.5 Serbia 43.0 46.8 10.3 38.3 26.0 20.9 33.3 16.8 11.6 Slovenia 56.0 32.3 11.8 39.7 29.6 15.2 34.1 22.4 9.0 Spain 32.5 47.0 20.5 34.6 29.2 17.8 20.7 15.5 8.3 Sweden 46.6 40.6 12.9 33.9 27.1 22.2 28.2 19.5 13.9 Switzerland 32.3 39.8 27.9 28.3 21.1 8.5 24.0 16.4 4.5 The Netherlands NA NA NA NA NA NA NA NA NA Ukraine 64.4 27.2 8.4 43.4 29.7 15.9 32.7 19.8 8.0 The UK 38.7 41.3 20.0 33.7 27.3 13.5 30.4 23.7 10.4 All 45.6 37.6 16.7 35.4 26.4 14.7 26.1 18.7 8.8 All: percentage of cycles per age group is computed among all countries giving the distribution. Pregnancy and delivery rates are computed on the countries providing them. For France and Iceland cycles refer to aspirations. For Belgium initiated cycles are left empty because cycles without oocyte aspiration are not classifiable into IVF/ICSI.

22 Supplementary Table SX Initiated cycles, pregnancy and delivery rates by age distribution (years) of women treated with ICSI in 2010. Country Cycles (%)... Pregnancy rate (%)... Delivery rate (%)... 34 35 39 40 34 35 39 40 34 35 39 40... Austria NA NA NA NA NA NA NA NA NA Belgium NA NA NA NA NA NA NA NA NA Bulgaria 38.3 40.8 20.8 33.5 31.2 14.2 28.6 23.7 8.7 Czech Republic NA NA NA NA NA NA NA NA NA Denmark 54.9 32.2 12.9 NA NA NA NA NA NA Finland 55.8 30.8 13.4 32.2 25.5 14.6 27.0 19.6 7.6 France 56.4 32.0 11.5 NA NA NA NA NA NA Germany 43.7 36.8 19.5 34.9 25.5 15.4 25.4 17.2 8.2 Greece 33.7 37.9 28.4 39.3 27.3 13.5 31.0 21.4 8.4 Hungary 52.9 33.6 13.4 35.0 28.8 14.8 NA NA NA Iceland 52.9 30.5 16.6 39.8 27.9 16.2 34.7 25.0 8.1 Ireland 37.3 44.6 18.1 35.8 27.8 18.0 29.1 22.2 13.4 Italy 29.4 41.3 29.3 29.1 22.2 10.6 21.2 15.5 5.5 Kazakhstan 69.8 24.4 5.7 33.3 34.1 15.0 23.5 23.5 5.0 Lithuania 58.5 30.2 11.3 41.9 31.3 0.0 NA NA NA Macedonia 52.0 24.2 23.8 51.9 31.2 16.3 45.1 27.4 5.8 Moldova 60.9 29.4 9.7 42.0 35.0 24.2 35.7 30.0 18.2 Montenegro 40.0 29.7 30.2 45.5 26.6 7.1 37.7 16.1 4.8 Norway 54.2 37.7 8.1 29.5 25.4 16.1 25.9 21.1 10.8 Poland 61.0 29.2 9.7 38.9 31.0 13.2 25.5 19.1 7.6 Portugal 47.1 39.3 13.7 34.4 27.4 14.5 27.5 21.3 8.3 Romania 47.9 40.6 11.5 52.6 45.5 39.0 NA NA NA Russia 57.5 30.2 12.3 36.9 30.7 19.7 27.2 20.9 10.4 Serbia 50.5 41.9 7.6 34.2 38.8 18.5 29.2 27.4 12.3 Slovenia 54.4 31.8 13.8 34.1 21.2 14.9 28.0 16.2 9.8 Spain 39.8 47.0 13.3 37.6 28.8 17.4 24.1 17.3 8.1 Sweden 51.0 38.3 10.7 35.2 25.7 16.1 28.6 19.1 9.8 Switzerland 37.1 40.9 22.0 30.8 22.1 10.4 25.7 16.6 5.1 The Netherlands NA NA NA NA NA NA NA NA NA Ukraine 60.0 28.8 11.2 41.4 30.1 17.1 35.3 24.4 11.5 The UK 45.5 39.0 15.5 37.2 29.8 16.8 33.7 26.1 12.9 All 45.2 37.5 17.3 35.2 26.6 14.0 28.5 18.5 7.7 All: percentage of cycles per age group is computed among all countries giving the distribution. Pregnancy and delivery rates are computed on the countries providing them. For France and Iceland cycles refer to aspirations. For Belgium initiated cycles are left empty because cycles without oocyte aspiration are not classifiable into IVF/ICSI.

23 Supplementary Table SXI Initiated cycles, pregnancy and delivery rates by age distribution (years) of women treated with FER in 2010. Country Cycles (%)... Pregnancies (%)... Deliveries (%)... 34 35 39 40 34 35 39 40 34 35 39 40... Austria NA NA NA NA NA NA NA NA NA Belgium 65.5 26.2 8.3 20.0 16.2 12.3 13.8 10.2 8.3 Bulgaria 51.8 36.4 11.8 24.8 16.2 31.3 19.9 13.1 18.8 Czech Republic 47.3 34.4 18.3 26.7 16.7 17.6 10.6 7.0 7.0 Denmark NA NA NA NA NA NA NA NA NA Finland NA NA NA NA NA NA NA NA NA France NA NA NA NA NA NA NA NA NA Germany 46.0 38.1 15.9 19.3 16.3 9.4 13.7 11.7 8.0 Greece 44.7 37.1 18.2 31.6 26.9 21.4 23.8 21.6 14.3 Hungary 59.0 33.2 7.8 23.8 18.8 14.7 NA NA NA Iceland 56.1 30.7 13.2 34.8 23.8 18.5 27.8 20.6 14.8 Ireland 23.8 57.8 18.4 24.3 15.9 13.6 18.1 13.7 9.3 Italy 39.6 43.5 16.9 19.8 18.0 8.8 14.7 11.1 5.2 Kazakhstan 57.1 26.6 16.2 27.4 21.6 25.4 18.8 17.5 22.0 Lithuania 77.8 22.2 0.0 35.7 50.0 NA NA NA NA Macedonia 57.1 30.6 12.2 17.9 33.3 33.3 10.7 26.7 16.7 Moldova NA NA NA NA NA NA NA NA NA Montenegro 66.7 33.3 0.0 50.0 NA NA 50.0 NA NA Norway 58.7 34.1 7.2 19.4 16.9 15.0 15.8 12.8 10.4 Poland 62.9 29.0 8.1 26.2 19.3 16.4 17.1 11.8 8.0 Portugal 50.2 38.1 11.7 25.4 23.6 19.8 20.5 15.9 14.3 Romania NA NA NA NA NA NA NA NA NA Russia 63.4 27.4 9.1 26.3 23.5 18.9 16.9 15.4 9.8 Serbia NA NA NA NA NA NA NA NA NA Slovenia 61.3 30.1 8.6 23.2 19.7 13.8 19.3 15.7 6.2 Spain 42.5 44.5 12.9 31.2 26.8 19.9 18.8 14.4 10.7 Sweden 43.2 44.6 12.2 30.2 24.0 21.8 24.0 18.1 14.0 Switzerland 37.8 42.4 19.8 21.1 18.8 16.0 16.2 13.0 9.0 The Netherlands NA NA NA NA NA NA NA NA NA Ukraine 68.1 22.4 9.5 30.0 22.9 25.4 23.7 16.2 16.4 The UK 43.4 39.5 17.1 23.9 22.2 16.3 21.5 19.4 13.5 All 49.1 37.1 13.8 23.6 20.0 14.8 21.4 18.0 13.4 All: percentage of cycles per age group is computed among all countries giving the distribution. Pregnancy and delivery rates are computed on the countries providing them.

24 Supplementary Table SXII Initiated cycles, pregnancy and delivery rates by age distribution (years) of women treated with ED in 2010. Country Cycles (%)... Pregnancies (%)... Deliveries (%)... 34 35 39 40 34 35 39 40 34 35 39 40... Austria NA NA NA NA NA NA NA NA NA Belgium 32.3 25.6 42.1 24.3 24.9 23.2 14.3 17.1 13.0 Bulgaria 14.0 26.7 59.3 75.0 73.9 35.3 66.7 43.5 33.3 Czech Republic 14.5 22.1 63.4 33.6 30.9 30.1 15.5 16.6 15.0 Denmark NA NA NA NA NA NA NA NA NA Finland 19.4 26.7 54.0 NA NA NA NA NA NA France NA NA NA NA NA NA NA NA NA Germany NA NA NA NA NA NA NA NA NA Greece 8.3 22.3 69.4 50.0 41.2 36.4 36.1 26.8 27.5 Hungary 37.1 28.6 34.3 46.2 60.0 50.0 NA NA NA Iceland 20.2 24.2 55.6 25.0 41.7 27.3 20.0 25.0 21.8 Ireland 10.0 50.0 40.0 100.0 30.0 37.5 100.0 30.0 25.0 Italy NA NA NA NA NA NA NA NA NA Kazakhstan 30.5 27.1 42.5 55.6 41.7 42.5 39.5 26.4 31.0 Lithuania NA NA NA NA NA NA NA NA NA Macedonia 19.2 30.8 50.0 80.0 62.5 38.5 80.0 25.0 30.8 Moldova NA NA NA NA NA NA NA NA NA Montenegro NA NA NA NA NA NA NA NA NA Norway NA NA NA NA NA NA NA NA NA Poland 23.6 32.8 43.7 39.0 47.4 42.1 32.9 34.2 31.6 Portugal 9.3 18.6 72.1 58.6 50.0 46.2 48.3 32.8 35.6 Romania 21.1 42.1 36.8 50.0 100.0 0.0 0.0 0.0 0.0 Russia 23.9 24.1 51.9 36.4 48.6 43.7 28.1 38.4 33.5 Serbia NA NA NA NA NA NA NA NA NA Slovenia 25.0 37.5 37.5 50.0 33.3 0.0 50.0 33.3 0.0 Spain 9.8 28.0 62.2 49.7 49.3 48.7 30.2 32.0 30.6 Sweden 38.9 50.6 10.5 33.8 28.4 31.4 29.2 22.5 22.9 Switzerland NA NA NA NA NA NA NA NA NA The Netherlands NA NA NA NA NA NA NA NA NA Ukraine 10.3 27.9 61.8 64.8 49.3 38.3 53.7 43.2 32.7 The UK 17.0 22.8 60.3 34.4 37.0 36.1 28.2 34.2 31.7 All 14.8 26.5 58.7 40.2 44.4 43.1 26.8 30.3 28.5 All: percentage of cycles per age group is computed among all countries giving the distribution. Pregnancy and delivery rates are computed on the countries providing them.

Supplementary Table SXIII Singleton, twin, and triplet deliveries after IVF and ICSI in 2010. Country Clinical Documented Lost to Deliveries all Deliveries with Singleton (n) % Twin (n) % Triplet % pregnancies pregnancy loss follow-up known multiplicity... Austria 2152 285 614 1253 1253 955 76.2 290 23.1 8 0.6 Belgium 4598 911 455 3232 3232 2866 88.7 359 11.1 7 0.2 Bulgaria 1339 279 0 1060 1060 658 62.1 379 35.8 23 2.2 Czech Republic Denmark 2973 2657 2657 2242 84.4 405 15.2 10 0.4 Finland 1378 273 0 1105 1105 985 89.1 117 10.6 3 0.3 France 14 818 0 11 558 11 381 9333 82.0 2018 17.7 30 0.3 Germany 12 371 2189 1665 8517 8514 5747 67.5 2432 28.6 335 3.9 Greece 769 136 31 602 556 389 70.0 150 27.0 17 3.1 Hungary 1562 Iceland 146 24 0 122 122 105 86.1 17 13.9 0 0.0 Ireland 846 160 1 685 684 549 80.3 130 19.0 5 0.7 Italy 10 984 2294 1182 7508 7508 5836 77.7 1531 20.4 141 1.9 Kazakhstan 560 117 34 409 401 303 75.6 94 23.4 4 1.0 Lithuania 33 Macedonia 542 87 22 433 433 285 65.8 141 32.6 7 1.6 Moldova 234 38 0 196 196 151 77.0 44 22.4 1 0.5 Montenegro 131 29 0 102 102 70 68.6 32 31.4 0 0.0 Norway 1787 285 0 1502 1502 1331 88.6 167 11.1 4 0.3 Poland 3062 302 471 2289 2289 1854 81.0 426 18.6 9 0.4 Portugal 1748 384 17 1347 1347 1066 79.1 272 20.2 9 0.7 Romania 380 78 Russia 8955 1635 863 6457 5914 4543 76.8 1306 22.1 65 1.1 Serbia 501 387 387 310 80.1 57 14.7 20 5.2 Slovenia 1062 210 0 852 852 724 85.0 128 15.0 0 0.0 Spain 9487 1755 2116 5616 5589 4246 76.0 1320 23.6 23 0.4 Sweden 3421 773 0 2648 2648 2492 94.1 153 5.8 3 0.1 Switzerland 1224 282 0 942 942 755 80.1 183 19.4 4 0.4 The Netherlands 4673 3529 3529 3152 89.3 372 10.5 5 0.1 Ukraine 1910 344 70 1496 1496 1122 75.0 357 23.9 17 1.1 The UK 13 016 1339 226 11 451 11 451 9173 80.1 2240 19.6 38 0.3 All 106 662 14 209 7767 77 955 77 150 61 242 79.4 15 120 19.6 788 1.0 For the Czech Republic, Hungary, Lithuania and Romania no data were available. Multiplicity is not known for all deliveries: France: 177, Germany: 3, Greece: 46, Ireland: 1, Kazakhstan: 8, Russia: 543 and Spain: 27. For Austria, no separate data for fresh cycles are available, FER cycles are also included here. 25

26 Supplementary Table SXIV Singleton, twin, triplet and quadruplet deliveries after FER in 2010. Country Clinical Documented Lost to Deliveries all Deliveries with Singleton (n) % Twin (n) % Triplet % pregnancies pregnancy loss follow-up known multiplicity... Austria Belgium 1617 356 167 1094 1094 963 88.0 129 11.8 2 0.2 Bulgaria 61 14 0 47 47 37 78.7 10 21.3 0 0.0 Czech Republic Denmark 572 493 493 420 85.2 70 14.2 3 0.6 Finland 815 230 0 588 588 545 92.7 43 7.3 0.0 France 3432 0 2477 2436 2194 90.1 239 9.8 3 0.1 Germany 3264 717 397 2150 2063 1731 83.9 310 15.0 22 1.1 Greece 129 27 4 98 94 58 61.7 34 36.2 2 2.1 Hungary 93 Iceland 60 11 0 49 49 44 89.8 5 10.2 0 0.0 Ireland 154 30 1 123 123 109 88.6 13 10.6 1 0.8 Italy 645 181 30 434 434 356 82.0 75 17.3 3 0.7 Kazakhstan 74 23 0 51 49 41 83.7 8 16.3 0 0.0 Lithuania 7 Macedonia 12 4 0 8 8 7 87.5 1 12.5 0 0.0 Moldova Montenegro 2 0 0 2 2 2 100.0 0 0.0 0 0.0 Norway 486 103 0 383 383 347 90.6 34 8.9 2 0.5 Poland 866 139 178 549 549 489 89.1 60 10.9 0 0.0 Portugal 187 44 3 140 140 122 87.1 17 12.1 1 0.7 Romania 51 17 Russia 928 234 131 563 555 445 80.2 107 19.3 3 0.5 Serbia Slovenia 162 32 0 130 130 114 87.7 16 12.3 0 0.0 Spain 2448 620 475 1353 1349 1129 83.7 216 16.0 4 0.3 Sweden 1378 327 0 1051 1051 1000 95.1 49 4.7 2 0.2 Switzerland 777 233 0 544 544 489 89.9 54 9.9 1 0.2 The Netherlands 1531 1055 1055 1006 95.4 49 4.6 0 0.0 Ukraine 334 63 20 251 251 203 80.9 46 18.3 2 0.8 The UK 2297 236 40 2021 2021 1674 82.8 346 17.1 1 0.0 All 22 382 3641 1446 15 654 15 508 13 525 87.2 1931 12.5 52 0.3 For Austria, the Czech Republic, Germany, Hungary, Lithuania, Moldova, Romania and Serbia no data were available. Multiplicity is not known for all deliveries: France: 41, Germany: 87, Greece: 4, Kazakhstan: 2, Russia: 8 and Spain: 4.

Supplementary Table SXV Weeks of gestation at delivery (%), according to multiplicity, in ART (fresh, FER and ED cycles together) 2010. Country Singleton Twin Triplet......... 20 27 28 32 33 36 371 Sum a NA 20 27 28 32 33 36 371 Sum NA 20 27 28 32 33 36 371 Sum a NA a weeks weeks weeks weeks weeks weeks weeks weeks weeks weeks weeks weeks... Austria 0.8 4.2 10.3 84.7 955 0 4.5 25.2 53.1 17.2 290 0 25.0 75.0 0.0 0.0 8 0 Belgium 0.8 1.7 8.1 89.5 4108 40 3.4 8.6 43.0 44.9 532 9 11.1 11.1 77.8 0.0 9 0 Bulgaria Czech Republic Denmark Finland 0.6 0.0 7.4 92.0 1542 6 4.4 0.0 42.5 53.1 161 1 0.0 0.0 100.0 0.0 3 0 France Germany Greece 7.3 23.8 30.1 38.8 521 0 0.0 39.2 52.7 8.1 222 0 7.4 18.5 66.7 7.4 27 0 Hungary Iceland 0.6 0.0 6.5 92.9 170 0 4.3 13.0 34.8 47.8 23 0.0 Ireland Italy Kazakhstan 13.1 26.7 26.2 34.0 413 16 14.5 31.6 29.1 24.8 125 0 25.0 37.5 0.0 37.5 9 1 Lithuania Macedonia 1.4 0.7 15.3 82.7 298 4 3.4 6.8 60.3 29.5 146 0 0.0 71.4 28.6 0.0 7 0 Moldova Montenegro 1.4 2.8 5.6 90.3 72 0 3.1 6.3 18.8 71.9 32 0 Norway Poland 3.3 12.0 15.0 69.7 1299 123 4.2 9.3 34.7 51.7 255 19 20.0 40.0 40.0 0.0 5 0 Portugal 0.9 1.3 10.4 87.5 1279 10 4.6 10.8 52.6 32.6 327 2 0.0 0.0 80.0 20.0 10 0 Romania Russia 1.1 1.7 6.4 90.8 5464 179 2.8 6.6 27.0 63.5 1580 61 11.0 31.5 43.8 13.7 74 1 Serbia 0.0 1.9 4.5 93.5 310 0 7.0 5.3 36.8 50.9 57 0 20.0 30.0 40.0 10.0 20 0 Slovenia 1.1 1.6 8.5 88.7 840 220 7.6 7.6 42.0 42.7 153 22 Spain 0.8 1.6 11.1 86.5 7916 1155 2.4 9.6 44.7 43.3 2433 449 10.0 20.0 60.0 10.0 36 6 Sweden 0.6 0.8 4.2 94.4 3598 19 5.5 4.0 25.4 65.2 206 5 40.0 40.0 20.0 0.0 5 0 Switzerland 0.9 1.0 9.0 89.0 1244 3 3.4 8.9 49.8 37.9 237 2 20.0 80.0 0.0 0 5 0 The Netherlands Ukraine The UK 0.7 1.8 6.9 90.6 11 404 17 3.0 10.3 38.9 47.8 2742 2 11.9 35.7 47.6 4.8 42 0 All 1.1 2.4 8.5 88.0 41 433 1792 3.3 10.4 39.9 46.3 9521 580 12.3 31.0 47.2 9.5 260 8 a Sum: sum of deliveries with data on term date. Percentages are computed on those deliveries. NA, deliveries with unknown term. 27

28 Supplementary Table XVI Complications and fetal reductions in 2010. Country Cycles OHSS Complications to oocyte retrieval... Fetal reduction All Bleeding Infection Maternal death... Austria 6402 Belgium 28 521 75 186 20 18 1 0 Bulgaria 5030 2 7 7 0 0 41 Czech Republic 20 020 53 9 9 0 0 Denmark 15 954 Finland 9312 65 17 11 6 0 France 79 427 30 Germany 62 571 111 164 309 0 0 Greece 3693 27 7 13 0 0 26 Hungary 5562 10 2 0 0 0 6 Iceland 824 5 1 1 0 0 0 Ireland 4078 13 6 3 3 0 0 Italy 58 860 162 119 111 8 0 0 Kazakhstan 2276 16 4 Lithuania 131 0 0 0 0 0 0 Macedonia 1497 21 26 20 Moldova 624 3 1 1 0 0 7 Montenegro 452 4 2 Norway 9007 63 11 7 4 0 0 Poland 13 325 56 33 29 4 0 0 Portugal 7179 47 5 2 3 0 Romania 1151 14 2 3 Russia 34 026 401 47 44 2 0 48 Serbia 1484 20 4 4 0 0 6 Slovenia 4419 34 1 1 0 0 Spain 58 735 180 55 27 5 1 62 Sweden 17 628 1 Switzerland 9540 22 22 3 0 0 8 The Netherlands 23 627 Ukraine 7085 96 11 11 0 0 38 The UK 57 856 139 All 550 296 1500 708 641 53 2 441

29 Supplementary Table SXVII Intrauterine insemination with husband semen (IUI-H) in 2010. Country Cycles Deliveries Deliveries (%) Singleton (%) Twin (%) Triplet (%)... Women,40 years Austria Belgium 10 127 663 6.5 96.4 3.6 0.0 Bulgaria 1906 237 12.4 91.6 8.4 0.0 Czech Republic Denmark 10 903 1487 13.6 89.7 9.7 0.6 Finland 3816 369 9.7 94.3 4.9 0.8 France Germany Greece 397 44 11.1 87.8 12.2 0.0 Hungary Iceland Ireland 1503 141 9.4 90.8 9.2 0.0 Italy 25 587 2014 7.9 89.0 9.9 1.0 Kazakhstan 778 63 8.1 100.0 0.0 0.0 Lithuania 145 Macedonia 556 50 9.0 74.0 10.0 2.0 Moldova 96 13 13.5 100.0 0.0 0.0 Montenegro 234 12 5.1 100.0 0.0 0.0 Norway 414 47 11.4 87.2 12.8 0.0 Poland 11 118 855 7.7 93.2 6.8 0.0 Portugal 1918 214 11.2 88.3 11.7 0.0 Romania 974 Russia 5607 727 13.0 90.5 8.4 1.1 Serbia 808 Slovenia 740 65 8.8 80.0 20.0 0.0 Spain 21 204 1635 7.7 88.6 10.9 0.6 Sweden Switzerland The Netherlands Ukraine 1466 180 12.3 96.9 3.1 0.0 The UK 7278 All 107 575 8816 9.0 90.4 8.9 0.6 Women 40 years Austria Belgium 1120 25 2.2 100.0 0.0 0.0 Bulgaria 203 14 6.9 78.6 21.4 0.0 Czech Republic Denmark 997 44 4.4 90.9 9.1 0.0 Finland 245 7 2.9 100.0 0.0 0.0 France Germany Greece 98 3 3.1 100.0 0.0 0.0 Hungary Iceland Ireland 188 8 4.3 100.0 0.0 0.0 Italy 6482 206 3.2 95.1 4.9 0.0 Continued

30 Supplementary Table SXVII Continued Country Cycles Deliveries Deliveries (%) Singleton (%) Twin (%) Triplet (%)... Kazakhstan 60 3 5.0 Lithuania 10 Macedonia 42 1 2.4 100.0 0.0 0.0 Moldova 14 1 7.1 100.0 0.0 0.0 Montenegro 22 0 0.0 Norway 21 2 9.5 100.0 0.0 0.0 Poland 772 34 4.4 90.6 9.4 0.0 Portugal 126 5 4.0 100.0 0.0 0.0 Romania 50 Russia 535 64 12.0 98.4 1.6 0.0 Serbia 112 Slovenia 0 0 Spain 883 20 2.3 90.0 10.0 0.0 Sweden Switzerland The Netherlands Ukraine 25 1 4.0 100.0 0.0 0.0 The UK 1016 All 13 021 438 3.7 94.7 5.3 0.0 Percentages of singleton, twin and triplet deliveries are counted on the total number of deliveries with known multiplicity.

31 Supplementary Table SXVIII Intrauterine insemination with donor semen (IUI-D) in 2010. Country Cycles Deliveries Deliveries (%) Singleton (%) Twin (%) Triplet (%)... Women,40 years Austria Belgium 5503 537 9.8 96.7 3.1 0.2 Bulgaria 611 128 20.9 74.2 25.8 0.0 Czech Republic Denmark 7248 1169 16.1 93.5 6.4 0.1 Finland 838 115 13.7 96.5 3.5 0.0 France Germany Greece 38 8 21.1 62.5 37.5 0.0 Hungary Iceland Ireland 219 47 21.5 95.7 4.3 0.0 Italy Kazakhstan 87 16 18.4 100.0 0.0 0.0 Lithuania Macedonia 40 5 12.5 80.0 20.0 0.0 Moldova 66 20 30.3 100.0 0.0 0.0 Montenegro Norway 382 72 18.8 91.7 8.3 0.0 Poland 1749 255 14.6 92.7 7.3 0.0 Portugal 157 25 15.9 88.0 12.0 0.0 Romania 80 Russia C.I.S. 1925 371 19.3 91.6 8.4 0.0 Serbia Slovenia 5 1 20.0 100.0 0.0 0.0 Spain 5385 710 13.2 87.2 12.1 0.7 Sweden 581 99 17.0 94.9 4.0 1.0 Switzerland The Netherlands Ukraine 609 88 14.4 92.0 8.0 0.0 The UK 3012 465 15.4 93.3 6.7 0.0 All 58 635 4131 14.5 91.9 7.9 0.2 Women 40 years Austria Belgium 715 27 3.8 100.0 0.0 0.0 Bulgaria 72 4 5.6 100.0 0.0 0.0 Czech Republic Denmark 2305 139 6.0 97.8 2.2 0.0 Finland 117 9 7.7 100.0 0.0 0.0 France Germany Greece 27 2 7.4 100.0 0.0 0.0 Hungary Iceland Ireland 56 7 12.5 100.0 0.0 0.0 Italy Continued

32 Supplementary Table SXVIII Continued Country Cycles Deliveries Deliveries (%) Singleton (%) Twin (%) Triplet (%)... Kazakhstan 7 1 14.3 Lithuania Macedonia 13 1 7.7 100.0 0.0 0.0 Moldova 7 1 14.3 100.0 0.0 0.0 Montenegro Norway 15 1 6.7 100.0 0.0 0.0 Poland 169 15 8.9 78.6 21.4 0.0 Portugal 4 0 0.0 Romania 40 Russia C.I.S. 473 97 20.5 96.9 3.1 0.0 Serbia Slovenia 2 0 0.0 Spain 732 52 7.1 94.2 5.8 0.0 Sweden 4 1 25.0 100.0 0.0 0.0 Switzerland The Netherlands Ukraine 13 0 0.0 The UK 794 41 5.2 92.7 7.3 0.0 All 5565 398 7.2 95.2 3.8 0.0 Percentages of singleton, twin and triplet deliveries are counted on the total number of deliveries with known multiplicity.

33 Supplementary Table SXIX The sum of fresh and FER ( cumulative ) delivery rates in 2010. Country Cycles Deliveries Multiple Thawings Deliveries Multiple Deliveries Deliveries Multiple deliveries deliveries deliveries IVF Fresh Fresh FER FER FER Fresh cycles Fresh and Fresh and and cycles cycles per initiated FER per FER per ICSI cycle (%) initiated total cycle (%) delivery (%)... Austria 6161 1253 298 620 20.3 20.3 23.8 Belgium 20 572 3232 366 8815 1094 131 15.7 21.0 11.5 Bulgaria 4673 1060 402 272 47 10 22.7 23.7 37.2 Czech Republic 12 864 4303 Denmark 12 234 2657 415 3371 493 73 21.7 25.7 15.5 Finland 4861 1105 120 588 43 22.7 34.8 9.6 France 56 492 11 558 2048 21 376 2477 242 20.5 24.8 16.3 Germany 51 720 8517 2767 17 876 2150 332 16.5 20.6 29.1 Greece 2754 602 167 461 98 36 21.9 25.4 29.0 Hungary 5091 Iceland 502 122 17 205 49 5 24.3 34.1 12.9 Ireland 3176 685 135 882 123 14 21.6 25.4 18.4 Italy 52 661 7508 1672 3758 434 78 14.3 15.1 22.0 Kazakhstan 1630 409 98 289 51 8 25.1 28.2 23.0 Lithuania 112 19 Macedonia 1409 433 148 49 8 1 30.7 31.3 33.8 Moldova 624 196 45 0 0 31.4 31.4 23.0 Montenegro 446 102 32 6 2 0 22.9 23.3 30.8 Norway 6557 1502 171 2443 383 36 22.9 28.7 11.0 Poland 8968 2289 435 3733 549 60 25.5 31.6 17.4 Portugal 5875 1347 281 921 140 18 22.9 25.3 20.1 Romania 923 208 Russia 27 310 6457 1371 3760 563 110 23.6 25.7 21.1 Serbia 1484 387 77 26.1 26.1 19.9 Slovenia 3604 852 128 760 130 16 23.6 27.2 14.7 Spain 32 503 5616 1343 8760 1353 220 17.3 21.4 22.4 Sweden 11 592 2648 156 5520 1051 51 22.8 31.9 5.6 Switzerland 5482 942 187 4058 544 55 17.2 27.1 16.3 The Netherlands 16 898 3529 377 49 20.9 20.9 12.1 Ukraine 5264 1496 374 1240 251 48 28.4 33.2 24.2 The UK 44 642 11 451 2278 10 476 2021 347 25.7 30.2 19.5 All 409 084 77 955 15 908 104 181 14 599 1983 20.0 23.7 19.3 For France the numbers are not initiated cycles, but aspirations.