Belo Horizonte and Rio de Janeiro, October 15th 2015

Minas Gerais: a large and important state 226,000 square miles (Larger than France or Spain) 20 million people (Comparable to Australia) 2 nd largest exporter in Brazil MG 3 rd largest GDP in Brazil GDP: US$ 197 billion (2012) 9.2% of Brazil Sources: CEI-FJP/IBGE

Located in the economic center of Brazil Close to Rio de Janeiro and São Paulo 40% of the national population; 63% of Brazilian GDP; 55% of country s purchase power; 64% of industrial production; 58% of electricity consumption. Mato Grosso do Sul Paraná Goiás São Paulo Santa Catarina DF Minas Gerais Bahia Rio de janeiro Espírito Santo Sources: IBGE, MME, SECEX/MDIC, 2012 Rio Grande Do Sul

Comparing Minas Gerais s GDP (2012) 16,244 Percentage of Minas Gerais in relation to the major economies of the world United States China Japan Germany France United Kingdom Brazil 1.3% 2.5% 3.5% 6.0% 7.9% 8.4% 9.2% 8,229 5,937 3,425 2,611 2,461 2,248 197 Source: World Bank (US$ billion)

Minas Gerais: a large pharma cluster in Brazil MG: 83 SP: 103 RJ: 16 PR: 14 RS: 19

Graduate in Pharmaceuticals in Minas Gerais 2500 2156 2109 2000 1500 1194 1000 500 331 0 Linhas de Pesquisa Presquisadores Estudantes Técnicos Source: CNPq - Censo dos Grupos de Pesquisa 2010.

FUNED - Ezequiel Dias Foundation FUNED is aligned with SUS policies (SUS: National Health System). It is a Minas Gerais state company and national domestic producer. FUNED produces drugs currently imported by the federal government. Participates in 7 partnerships (PDPs) with private companies. FUNED has a modern biotechnology factory with more than 2.500 m².

Pharma Companies in Minas Gerais

INDI MG Instituto de Desenvolvimento Integrado de Minas Gerais INDI is the investment promotion agency of Minas Gerais State (1968). INDI acts in the prospection, induction and attraction of investments for sustainable development of Minas Gerais. The INDI provides full assistance without costs to potential investors. Dialogue with other government agencies with regard to environmental issues (SEMAD), tax relief (SEF) and location of investment INDI is part of Minas Gerais system for economic development: science and technology agency Fapemig, local development bank BDMG, state investor CODEMIG, state energy company CEMIG and state-owned drug company FUNED. INDI also cooperates with local business association, such as FIEMG (manufacturing sector) and SEBRAE (small business sector).

INDI MG Instituto de Desenvolvimento Integrado de Minas Gerais How can INDI help you? Information and research, Selection of sites, Infrastructure and project implementation, Support in the process of environmental licensing, Identifying funding solutions through our partners, Discussing special tax regimes, Promoting the investor (federal, local and municipal levels).

INDI MG Instituto de Desenvolvimento Integrado de Minas Gerais Biomm case: production of human insulin. Biomm holds technology for large-scale production of recombinant insulin. Biomm will be able to produce other biosimilars in its new industrial plant. Biopharmaceutical plant under construction (operation scheduled to 2017). Location: Nova Lima, close to Metropolitan Region of Belo Horizonte. The Biomm project relies on the support of several local and federal agencies and institutions: BNDES, BDMG, Fapemig and Finep. Recent case: Unitec Semiconductors had support from INDI, Codemig, Finep, CEMIG and Copasa. Shareholders: Berbill, BNDESPar, IBM, BDMG, MATEC e WS-Intecs. Other cases of partnership: FIAT (cars and trucks), Helibras (helicopters, with Airbus Helicopters), CBMM (niobium minning), Bunge Fertilizantes (phosphate mining), Renova (renewable energy, CEMIG with SunEdison).

Thank you! Ricardo Ruiz VP ricardo.ruiz@indi.mg.gov.br Telephone: +55 (31) 3915-2851 Telephone: +55 (31) 3915-2838 presidencia@indi.mg.gov.br www.indi.mg.gov.br Belo Horizonte, October 15th 2015