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-Antimicrobial Agents and Chemotherapy American Society for Microbiology (ASM) -Journal of Antimicrobial Chemotherapy British Society of Antimicrobial Chemotherapy (BSAC) -Journal of Clinical Microbiology American Society for Microbiology (ASM) -Applied and Environmental Microbiology American Society for Microbiology (ASM) -FEMS Microbiology Letters Federation of European Microbiological Societies (FEMS) -Emerging Infectious Diseases Centers for Disease Control and Prevention (CDC) -International Journal of Antimicrobial Agents European Society f Chemotherapy (ESC) -Clinical Microbiology and Infection European Society of Clinical Microbiology and Infectious Diseases (ESCMID) -Future Microbiology Future Medicine - ( ) ( ). ) ISI : 143 ISI : 6 : 4 : 11 : 50 : 60 (IF): IF: 608,7 IF: 4,26 (citations)* : 3.227. ISI, SCI Expanded, ScienceDirect & Scopus.

ISI 1. MENTIS A, TZOUVELEKIS L, MAVROMMATI L. Susceptibility of fifteen Chlamydia trachomatis strains isolated in Greece. Journal of Antimicrobial Chemotherapy 1989; 24: 94. 1 5,068 2. LEGAKIS N, TZOUVELEKIS L, MAKRIS A, KOTSIFAKI H. Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin. Antimicrobial Agents and Chemotherapy 1989; 33: 124-127. 77 4,841 3. TZOUVELEKIS L, TUMAH H, MALLIARA K, LEGAKIS N. Relationship of antibiotic resistance phenotype to R-pyocin susceptibility pattern in clinical isolates of Pseudomonas aeruginosa. Journal of Chemotherapy 1989; 1: 226-230. 4 1,084 4. VATOPOULOS A, PHILIPPON A, TZOUVELEKIS L, KOMNINOU Z, LEGAKIS N. Prevalence of a transferable SHV-5 type -lactamase in clinical isolates of Klebsiella pneumoniae and Escherichia coli in Greece. Journal of Antimicrobial Chemotherapy 1990; 26: 635-648. 48 5,068 4a. MENTIS A, TZOUVELEKIS L, SPILIADIS C, BLACKWELL C, WEIR D. Inhibition of Helicobacter pylori haemagglutination activity by human salivary mucins. Microbiology Immunology (FEMS) 1990; 64: 125-128. 12 2,441 5. TZOUVELEKIS LS, MENTIS AF, MAKRIS A, SPILIADIS C, BLACKWELL C, WEIR D. In vitro binding of Helicobacter pylori to human gastric mucin. Infection and Immunity 1991; 59: 4252-4254. µ 72 4,165 6. VATOPOULOS AC, TSAKRIS A, TZOUVELEKIS LS, LEGAKIS NJ, PITT TL, MILLER GH, SHAW KJ, ANTREOU M, NIKOLOPOULOU M, KOMNINOU Z. "Diversity of aminoglycoside resistance in Enterobacter cloacae in Greece". European Journal of Clinical Microbiology and Infectious Diseases 1992; 11:131-138. 4 2,859 7. TSAKRIS A, VATOPOULOS AC, JOHNSON AP, PITT TL, LEGAKIS NJ, TZOUVELEKIS LS. "Prevalence of a plasmid-mediated type II dihydrofolate reductase gene among trimethoprim-resistant urinary pathogens in Greek hospitals". Journal of Antimicrobial Chemotherapy 1992; 29:405-413. 5

5,068 8. TZELEPI E, TZOUVELEKIS LS, VATOPOULOS AC, MENTIS AF, TSAKRIS A, LEGAKIS NJ. "High prevalence of stably derepressed class-i -lactamase expression in multiresistant clinical isolates of Enterobacter cloacae from Greek hospitals". Journal of Medical Microbiology 1992; 37:91-95. 24 2,502 9. TZOUVELEKIS LS, TZELEPI E, MENTIS AF, VATOPOULOS AC, TSAKRIS A. "Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability". FEMS Microbiology Letters 1992; 95:195-200. 21 2,044 10. TZOUVELEKIS LS, MENTIS AF, TZELEPI E, TSAKRIS A, KYRIAKIS K, LEGAKIS NJ. "Exposure effects of netilmicin on Enterobacter cloacae clinical isolates". Chemotherapy 1992; 38:405-409. µ µ 1 1,816 10a.TSAKRIS A, VATOPOULOS A, TZOUVELEKIS L, LEGAKIS N. Diversity of resistance phenotypes and plasmid analysis in multiresistant O:12 Pseudomonas aeruginosa. European Journal of Epidemiology 1992; 8: 575-580. 9 4,713 11. TSAKRIS A, JOHNSON AP, LEGAKIS NJ, TZOUVELEKIS LS. "Prevalence of the type I and type II DHFR genes in trimethoprim-resistant urinary isolates of Escherichia coli from Greece". Journal of Antimicrobial Chemotherapy 1993; 31:665-671. 13 5,068 12. TZOUVELEKIS LS, TZELEPI E, MENTIS AF, TSAKRIS A. "Identification of a novel plasmid-mediated -lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae". Journal of Antimicrobial Chemotherapy 1993; 31:645-654. 54 5,068 13.LEGAKIS NJ, TZOUVELEKIS LS, TSAKRIS A, LEGAKIS JN, VATOPOULOS AC. "On the incidence of antibiotic resistance among aerobic gram-negative rods isolated in Greek hospitals". Journal of Hospital Infection 1993; 24:233-237. 9 3,393 14.HEISIG P, TZOUVELEKIS LS, VATOPOULOS AS, LEGAKIS NJ. Ciprofloxacin resistance in enterobacterial clinical isolates. Journal of Antimicrobial Chemotherapy 1993; 33:887-888. 3 5,068 15.TZOUVELEKIS LS, TZELEPI E, KAUFMANN ME, MENTIS A. Consecutive mutations leading to the in vivo emergence of imipenem resistance in a clinical strain of Enterobacter aerogenes. Journal of Medical Microbiology 1994; 40:403-407.

21 2,502 16.TZOUVELEKIS LS, TZELEPI E, MENTIS AF. Nucleotide sequence of a plasmid- mediated cephalosporinase gene (blalat-1) found in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy 1994; 38:2207-2209. 32 4,841 17.GIANELLI D, TZELEPI E, TZOUVELEKIS LS, MENTIS AF, NICOLOPOULOU C. Dissemination of cephalosporin resistant Serratia marcescens strains producing a plasmidic SHV type -lactamase in Greek hospitals. European Journal of Clinical Microbiology and Infectious Diseases 1994; 13:764-767. 21 2,859 18.DOUBOYAS J, TZOUVELEKIS LS, TSAKRIS A. "In-vitro activity of ampicillin/sulbactam against multiresistant Acinetobacter calcoaceticus var. anitratus clinical isolates". Journal of Antimicrobial Chemotherapy 1994; 34:298-300. 11 5,068 19.LEGAKIS NJ, TZOUVELEKIS LS, HATZOUDIS G, TZELEPI E, GOURKOU A, PITT TL, VATOPOULOS AC. Dissemination of plasmids encoding an SHV-5 type beta- lactamase among Klebsiella pneumoniae strains isolated in Greek hospitals. Journal of Hospital Infection 1995; 31:177-187. 28 3,393 20.LEGAKIS NJ, MANIATIS A, TZOUVELEKIS LS. Prevalent mechanisms of resistance among enterobacteria isolated in Greek hospitals. Microbial Drug Resistance 1996; 1:331-333. 4 2,153 20a.TZOUVELEKIS LS, TZELEPI E, MENTIS AF, LEGAKIS NJ. Activity of cefpirome against selected clinical enterobacterial isolates with -lactamase-mediated resistance. Infection 1995; 23: 384-388. 5 2,659 21.TZOUVELEKIS LS, PRINARAKIS E, GAZOULI M, MIRIAGOU V, TZELEPI E, LEGAKIS NJ. In vitro activity of cefetamet against enterobacteria expressing an SHV-5 type -lactamase. Chemotherapy 1996; 42:324-328. 2 1,816 22.PRINARAKIS E, TZELEPI E, GAZOULI M, MENTIS AF, TZOUVELEKIS LS. Characterization of a novel SHV -lactamase variant that resembles the SHV-5 enzyme. FEMS Microbiology Letters 1996; 139:229-234. 18 2,044 23.GEORGOPOULOS S, MENTIS AF, SPILIADIS CA, TZOUVELEKIS LS, TZELEPI E, MOSHOPOULOS A, SKANDALIS N. Helicobacter pylori infection in spouses of patients with

duodenal ulcers and comparison of ribosomal RNA gene patterns. Gut 1996; 39:634-638. µ 69 10,111 24.GAZOULI M, TZOUVELEKIS LS, PRINARAKIS E, TZELEPI E. Transferable cefoxitin resistance in enterobacteria isolated in Greek hospitals and characterization of a plasmid-mediated group 1 -lactamase (LAT-2). Antimicrobial Agents and Chemotherapy 1996; 40:1736-1740. 48 4,841 25.GAZOULI M, KAUFMANN M, TZELEPI E, DIMOPOULOU H, PANIARA O, TZOUVELEKIS LS. Study of an outbreak of cefoxitin-resistant Klebsiella pneumoniae in a general hospital. Journal of Clinical Microbiology 1997; 35:508-510. 30 4,153 26.TZOUVELEKIS LS, GAZOULI M, PRINARAKIS EE, TZELEPI E, LEGAKIS NJ. Comparative evaluation of the inhibitory activities of the novel penicillanic acid sulfone Ro 48-1220 against - lactamases that belong to groups 1, 2b, and 2be. Antimicrobial Agents and Chemotherapy 1997; 41:475-477. 18 4,841 27.PRINARAKIS E, MIRIAGOU V, TZELEPI E, GAZOULI M, TZOUVELEKIS LS. Emergence of an inhibitor-resistant -lactamase (SHV-10) derived from an SHV-5 variant. Antimicrobial Agents and Chemotherapy 1997; 41:838-840. µ 85 4,841 28.TZOUVELEKIS LS, ZISSIS NP, GAZOULI M, TZELEPI E, LEGAKIS NJ. In vitro comparative assessment of -lactamase inhibitors and their penicillin combinations against selected enterobacteria. International Journal of Antimicrobial Agents 1997; 8: 193-197. 5 4,128 29.TZELEPI E, AVGERINOU H, KYRIAKIS K, TZOUVELEKIS LS, FLEMETAKIS A, KALOGEROPOULOU A, FRANGOULI E. Antimicrobial susceptibility and types of Neisseria gonorrhoeae in Greece. Data from the four-year period 1990-1993. Sexually Transmitted Diseases 1997; 24:378-385. µ 15 2,873 29a.TSAKRIS A, TZOUVELEKIS LS, DOUBOYAS J, PANAGEA T, TZELEPI E. Diversity of - lactamases among Klebsiella pneumoniae strains isolated in a university hospital. European Journal of Epidemiology 1997; 13:103-107. 8 4,713 30.GAZOULI M, SIDORENKO S, TZELEPI E, KOZLOVA N, GLADIN NP, TZOUVELEKIS LS. A plasmid-mediated -lactamase conferring resistance to cefotaxime in a clone of Salmonella typhimurium found in St.-Petersburg, Russia. Journal of Antimicrobial Chemotherapy 1997; 41:119-121.

µ 30 5,068 31.TSAKRIS A, DOUBOYAS J, TZOUVELEKIS LS. High rates of resistance to piperacillintazobactam among Escherichia coli and Klebsiella pneumoniae strains isolated in a Greek hospital. Diagnostic Microbiology and Infectious Diseases 1997; 28:39-41. 5 2,528 32.TZOUVELEKIS LS, TZELEPI E, PRINARAKIS E, GAZOULI M, KATRAHOURA A, GIAKKOUPI P, PANIARA O, LEGAKIS NJ. Sporadic emergence of cefepime and cefpirome resistant Klebsiella pneumoniae strains in Greek hospitals. Journal of Clinical Microbiology 1998; 36:266-268. 22 4,153 33.GIAKKOUPI P, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Substitution of Arg-244 for Cys or Ser in SHV-1 and SHV-5 -lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes. FEMS Microbiology Letters 1998; 160:49-54. µ 8 2,044 34.GAZOULI M, TZELEPI E, SIDORENKO SV, TZOUVELEKIS LS. Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A -lactamase (CTX- M-4): involvement of serine 237 in cephalosporin hydrolysis. Antimicrobial Agents and Chemotherapy 1998; 42:1259-1262. - µ 74 4,841 35.GIAKKOUPI P, MIRIAGOU V, GAZOULI M, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Properties of mutant SHV-5 -lactamases constructed by substitution of Met to Ile or Val at position 69. Antimicrobial Agents and Chemotherapy 1998; 42: 1281-1283. µ 8 4,841 36.TZOUVELEKIS LS, TZELEPI E, MANIATIS A, VOGIATZAKIS E, PANIARA O, TSELENTIS Y, LEGAKIS NJ. Amoxicillin-clavulanate resistance as related to - lactamase content in Escherichia coli strains from community acquired urinary tract infections. Clinical Microbiology and Infection 1998; 4:321-324. 3 4,540 37.PRINARAKIS EE, TZOUVELEKIS LS, LEGAKIS NJ. Activity of loracarbef against TEM extendedspectrum -lactamase-producing Escherichia coli strains and its interaction with the enzymes. Chemotherapy 1998; 44: 260-264. 1 1,816 38.TZOUVELEKIS LS, GAZOULI M, MARKOGIANNAKIS A, PARASKAKI E, LEGAKIS NJ, TZELEPI E. Emergence of third-generation cephalosporin-resistant Salmonella typhimurium in Greece: report of the first three cases. Journal of Antimicrobial Chemotherapy 1998; 42: 273-275. 20 5,068

39.GAZOULI M, TZELEPI E, MARKOGIANNAKIS A, LEGAKIS NJ, TZOUVELEKIS LS. Two novel plasmid-mediated cefotaxime-hydrolyzing -lactamases (CTX-M-5 and CTX-M-6) from Salmonella typhimurium. FEMS Microbiology Letters 1998; 165:289-293. 58 2,044 40.GAZOULI M, TZOUVELEKIS LS, VATOPOULOS AC, TZELEPI E. Transferable class C - lactamases in Escherichia coli strains isolated in Greek hospitals and characterization of two enzyme variants (LAT-3 and LAT-4) closely related to Citrobacter freundii AmpC -lactamase. Journal of Antimicrobial Chemotherapy 1998; 42:419-425. 40 5,068 41.GAZOULI M, LEGAKIS NJ, TZOUVELEKIS LS. Effect of substitution of Asn for Arg-276 in the cefotaxime-hydrolyzing class A -lactamase CTX-M-4. FEMS Microbiology Letters 1998; 169:289-293. µ 25 2,044 42.DEMETZOS C, STAHL B, ANASTASSAKI T, GAZOULI M, TZOUVELEKIS LS, RALLIS M. Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds. Planta Medica 1998; 65:76-78. 39 2,153 43.GIAKKOUPI P, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Aspartic acid for asparagine substitution at position 276 decreases susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 -lactamases. Journal of Antimicrobial Chemotherapy 1999; 43:23-29. µ 13 5,068 44.KYRIAKIS KP, TZELEPI E, FLEMETAKIS A, AVGERINOU H, TZOUVELEKIS LS, FRANGOULI E. Epidemiological aspects of male gonococcal infection in Greece. Sexually Transmitted Diseases 1999; 26:43-48. 12 2,873 45.TZELEPI E, KOUPPARI G, MAVROIDI A, ZAPHIROPOULOU A, TZOUVELEKIS LS. Erythromycin-resistant group A -haemolytic streptococci isolated in a paediatric hospital in Athens, Greece. Journal of Antimicrobial Chemotherapy 1999; 43: 745-746. 21 5,068 46.TZOUVELEKIS LS, VATOPOULOS AC, KATSANIS G, TZELEPI E. A rare case of failure by an automated system to detect extended-spectrum -lactamase in a cephalosporin-resistant Klebsiella pneumoniae isolate. Journal of Clinical Microbiology 1999; 37:2388. µ 29 4,153 47.TZOUVELEKIS LS, BONOMO RA. SHV-type -lactamases. Current Pharmaceutical Design 1999; 5:847-864.

43 3,870 48.TASSIOS PT, GAZOULI M, TZELEPI E, MILCH H, KOZLOVA N, SIDORENKO SV, LEGAKIS NJ, TZOUVELEKIS LS. Spread of a Salmonella typhimurium clone resistant to third generation cephalosporins in three European countries. Journal of Clinical Microbiology 1999; 37:3774-3777. 58 4,153 49.GIAKKOUPI P, TZELEPI E, TASSIOS PT, LEGAKIS NJ, TZOUVELEKIS LS. Detrimental effect of the combination of R164S with G238S in TEM-1 -lactamase on the extended-spectrum activity conferred by each single mutation. Journal of Antimicrobial Chemotherapy 2000; 45:101-104. µ 9 5,068 50.TZOUVELEKIS LS, TZELEPI E, TASSIOS PT, LEGAKIS NJ. CTX-M-type - lactamases: an emerging group of extended-spectrum enzymes. International Journal of Antimicrobial Agents 2000; 13:137-142. 164 4,128 51.LOUKOVA V, TZOUVELEKIS LS, TASSIOS PT, THIEL W. (2000). Extended- spectrum - lactamases in Salmonella strains isolated in Austria. International Journal of Antimicrobial Agents. 2000; 15:155-156. 2 4,128 52.TASSIOS PT, CHATZICHRISTODOULOU C, LAMBIRI M, KANSOUZIDOU A, SARANDOPOULOU A, KREAMASTINOU J, TZOUVELEKIS LS, LEGAKIS NJ. Molecular typing of multi-drug resistant Salmonella blockley outbreak isolates from Greece. Emerging Infectious Diseases. 2000; 6: 60-64. µ 18 6,169 53.GIAKKOUPI P, TZOUVELEKIS LS, TSAKRIS A, LOUKOVA V, SOFIANOU D, TZELEPI E. Characterization of IBC-1, a novel integron-associated extended- spectrum -lactamase from Enterobacter cloacae. Antimicrobial Agents and Chemotherapy 2000; 44:2247-2253. 66 4,841 54.MAVROIDI A, TZOUVELEKIS LS, TASSIOS PT, FLEMETAKIS A, DANIILIDOU M, TZELEPI E. Characterization of Neisseria gonorrhoeae strains with decreased susceptibility to fluoroquinolones isolated in Greece from 1996 to 1999. Journal of Clinical Microbiology 2000; 38:3489-3491. µ 16 4,153 55.MAVROIDI A, TSAKRIS A, TZELEPI E, TZOUVELEKIS LS. VIM-2 metallo- - lactamaseproducing Pseudomonas aeruginosa from Greece. Journal of Antimicrobial Chemotherapy 2000; 46:1041-1043. 45

5,068 56.TZELEPI E, ARVANITIDOU, TZOUVELEKIS LS, MAVROIDI A, TSAKRIS A. The isoelectric focusing patterns of -lactamases of Yersinia enterocolitica from aquatic environments. Journal of Antimicrobial Chemotherapy 2000; 46:513-514. 4 5,068 57.GIAKKOUPI P, HUJER AM, TZELEPI E, MIRIAGOU V, BONOMO RA, TZOUVELEKIS LS. Substitution of Thr for Ala-237 in TEM-17, TEM-12 and TEM- 24: alterations in -lactam resistance conferred on Escherichia coli. FEMS Microbiology Letters 2001; 201:37-40. µ 7 2,044 58.PETINAKI E, MIRIAGOU V, TZOUVELEKIS LS, POURNARAS S, HATZI F, KONTOS F, MANIATI M, MANIATIS AN. Methicillin-resistant Staphylococcus aureus in the hospitals of central Greece. International Journal of Antimicrobial Agents 2001; 18:61-65. 18 4,128 59.MAVROIDI A, TZOUVELEKIS LS, KYRIAKIS KP, AVGERINOU H, DANIILIDOU M, TZELEPI E. Chromosomal mutations in multiple antibiotic resistant Neisseria gonorrhoeae. Antimicrobial Agents and Chemotherapy 2001; 45:2651-2654. 25 4,841 60.MAVROIDI A, TZELEPI E, TSAKRIS A, MIRIAGOU V, SOFIANOU D, TZOUVELEKIS LS. An integron-associated -lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extendedspectrum -lactamase IBC-1. Journal of Antimicrobial Chemotherapy 2001; 48:627-630. 41 5,068 61. AQEL A, MANIATIS AN, LEGAKIS NJ, TZOUVELEKIS LS. Mupirocin-resistant Staphylococcus aureus in Greek hospitals. International Journal of Antimicrobial Agents 2001; 18:407-408. 3 4,128 62.LEBESSI E, DELAGRAMMATICAS H, TASSIOS PT, TZOUVELEKIS LS, IOANNIDOU S, FOUSTOUKOU M, LEGAKIS NJ. Extended-spectrum -lactamase- producing Klebsiella pneumoniae in a neonatal intensive care unit in the high- prevalence area of Athens, Greece. Journal of Clinical Microbiology 2002; 40:799-804. µ 26 4,153 63.MAVROIDI A, TZELEPI E, MIRIAGOU V, GIANNELI D, LEGAKIS NJ, TZOUVELEKIS LS. CTX- M-3-producing Escherichia coli from Greece. Microbial Drug Resistance 2002; 8:35-37. 9 2,153 64.PETINAKI E, MIRIAGOU V, TZOUVELEKIS LS, HATZI F, LEGAKIS NJ, MANIATIS AN. Evaluation of an anti-pbp 2a slide latex agglutination test in coagulase- negative staphylococci isolated in Greek hospitals. Diagnostic Microbiology and Infectious Diseases 2002; 42:279-282.

µ 4 2,528 65.VILLA L, MAMMINA C, MIRIAGOU V, TZOUVELEKIS LS, TASSIOS PT, NASTASI A, CARATTOLI A. Multi-drug, broad-spectrum cephalosporin resistance among Salmonella enterica serotype Enteritidis clinical isolates in Southern Italy. Journal of Clinical Microbiology 2002; 40:2662-2665. 34 4,153 66.KYRIAKIS KP, TZELEPI E, AVGERINOU H, TZOUVELEKIS LS, FLEMETAKIS A, FRANGOULI E. Current characteristics of male gonorrhoea outpatients in Athens, Greece. Sexually Transmitted Infections 2002; 78:E5. - 2,854 67.MIRIAGOU V, FILIP R, COMAN G, TZOUVELEKIS LS. Expanded-spectrum cephal sporinresistant Salmonella strains in Romania. Journal of Clinical Microbiology 2002; 40:4334-4336. µ 24 4,153 68.POURNARAS S, TSAKRIS A, MANIATI M, TZOUVELEKIS LS, MANIATIS AN. Identification of a novel metallo- -lactamase gene (blavim-4) in Pseudomonas aeruginosa. Antimicrobial Agents and C erapy 2002; 46:4026-4028. 51 4,841 69.MIRIAGOU V, TZELEPI E, GIANNELI D, TZOUVELEKIS LS. Escherichia coli with a self-transferable, multi-resistant plasmid coding for the metallo- -lactamase VIM-1. Antimicrobial Agents and Chemotherapy 2003; 47:395-397. 83 4,841 70.LEBESSI E, STAMOS G, FOUSTOUKOU M, VOURLI S, LEGAKIS NJ, TZOUVELEKIS LS. Performance of ESBL detection methods in clinical enterobacteria producing IBC-1. Journal of Clinical Microbiology 2003; 41:912. µ 1 4,153 71.GIAKKOUPI P, PETRIKKOS G, TZOUVELEKIS LS, TSONAS S, THE WHO-NET STUDY GROUP, LEGAKIS NJ, VATOPOULOS AC. Spread of integron-associated blavim genes among Pseudomonas aeruginosa strains in Greek hospitals. Journal of Clinical Microbiology 2003; 41:822-825. µ 41 4,153 72.TZOUVELEKIS LS, LUKOVA V, TASSIOS PT, FLUIT J, LEGAKIS NJ. - Lactamase-mediated resistance among Salmonella isolates from European hospitals. Clinical Microbiology and Infection 2003; 9:149-152. 7 4,540

73.TZELEPI E, MAGANA H, PLATSOUKA E, SOFIANOU D, LEGAKIS NJ, TZOUVELEKIS LS. Extended-spectrum -lactamase types in Klebsiella pneumoniae and Escherichia coli in two Greek hospitals. International Journal of Antimicrobial Agents 2003; 21:285-288. 37 4,128 74.MIRIAGOU V, TZOUVELEKIS LS, ROSSITER S, TZELEPI E, ANGULO FJ, WHICHARD J. Imipenem resistance ia a Salmonella strain due to plasmid-mediated class A carbapenemase KPC-2. Antimicrobial Agents and Chemotherapy 2003; 47:1297-1300. 112 4,841 75.VOURLI S, KARTALI G, KONTOPOULOU C, SOFIANOU D, TZOUVELEKIS LS, TZELEPI E. Characterization of Klebsiella pneumoniae clinical strains producing a rare extended-spectrum - lactamase of the IBC type. International Journal of Antimicrobial Agents 2003; 21:495-497. 5 4,128 76.POURNARAS S, MANIATI M, PETINAKI E, TZOUVELEKIS LS, TSAKRIS A, LEGAKIS NJ, MANIATIS AN. Hospital outbreak of multiple clones of Pseudomonas aeruginosa carrying the unrelated beta-lactamase variants blavim-2 and blavim-4. Journal of Antimicrobial Chemotherapy 2003; 51:1409-1414. µ 53 5.068 77.VOURLI S, TZOUVELEKIS LS, TZELEPI E, LEBESSI E, LEGAKIS NJ, MIRIAGOU V. Characterization of In111, a novel class 1 integron that carries the extended-spectrum -lactamase gene blaibc-1. FEMS Microbiology Letters 2003; 255:149-153. 19 2,044 78.GIAKKOUPI P, XANTHAKI A, KANELOPOULOU M, VLAHAKI A, MIRIAGOU V, KONTOU S, PAPAFRAGGAS E, MALAMOU H, TZOUVELEKIS LS, LEGAKIS NJ, VATOPOULOS AC. VIM-1 metallo- -lactamase-producing Klebsiella pneumoniae strains in Greek hospitals. Journal of Clinical Microbiology 2003; 41:3893-3896. µ 100 4,153 79.CHANIOTAKI S, GIAKKOUPI P, TZOUVELEKIS LS, PANAGIOTAKOS D, KOZANITOU M, PETRIKKOS G, AVLAMI A, THE WHONET STUDY GROUP, VATOPOULOS AC. Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece. Clinical Microbiology and Infection 2004; 10:75-78. 18 4,540 80.VOURLI S, GIAKKOUPI P, MIRIAGOU V, TZELEPI E, VATOPOULOS AC, TZOUVELEKIS LS. Novel GES/IBC extended-spectrum -lactamase variants with carbapenemase activity in clinical enterobacteria. FEMS Microbiology Letters 2004; 234:209-213. 50 2,044

81.MIRIAGOU V, TASSIOS PT, LEGAKIS NJ, TZOUVELEKIS LS. (2004). Expanded- spectrum cephalosporin resistance in non-typhoid Salmonella. International Journal of Antimicrobial Agents 2004; 23:547-555. 47 4,128 82.MIRIAGOU V, TZOUVELEKIS LS, VILLA L, LEBESSI E, VATOPOULOS AC, CARATTOLI A, TZELEPI E. CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid. Antimicrobial Agents and Chemotherapy 2004; 48:3172-3174. 28 4,841 83.GANGOUE-PIEBOJI J, MIRIAGOU V, VOURLI S, TZELEPI E, NGASSAM P, TZOUVELEKIS LS. Emergence of CTX-M-15-producing enterobacteria in Cameroon and characterization of a blactx-m-15 element. Antimicrobial Agents and Chemotherapy 2005; 49:441-443. 37 4,841 84.GIAKKOUPI P, TZOUVELEKIS LS, DAIKOS GL, MIRIAGOU V, PETRIKKOS G, LEGAKIS NJ, VATOPOULOS AC. Discrepancies and interpretation problems in susceptibility testing of VIMproducing Klebsiella pneumoniae. Journal of Clinical Microbiology 2005; 43:494-496. 26 4,153 85.MIRIAGOU V, TZELEPI E, DAIKOS GL, TASSIOS PT, TZOUVELEKIS LS. Panresistance in metallo- -lactamase-producing Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy 2005; 55:810-811. 23 5,068 86.POLITI L, TASSIOS PT, LAMPIRI M, KANSOUZIDOU A, PASIOTOU A, MELOU K, VATOPOULOS AC, LEGAKIS NJ, TZOUVELEKIS LS. Repeated occurrence of ESBLs among minor serotypes of Salmonella enteritidis. Journal of Clinical Microbiology 2005; 43:3453-3455. 22 4,153 87.CHATZIPANAGIOTOU S, IOANNIDOU V, IOANNIDIS A, NICOLAOU C, PAPAVASILEIOU E, CHANIOTAKI S, VATOPOULOS A, TZOUVELEKIS L, LEGAKIS NJ. Absence of the plasmidmediated quinolone resistance qnra gene among Campylobacter jejuni clinical isolates from Greece. International Journal of Antimicrobial Agents 2005; 26:261-262 4 4,128 88.MIRIAGOU V, CARATTOLI A, TZELEPI E, VILLA L, TZOUVELEKIS LS. IS26- associated In4- type integrons forming multiresistant loci in enterobacterial plasmids. Antimicrobial Agents and Chemotherapy 2005; 49:3541-3543. 32 4,841 89. POURNARAS S, IKONOMIDIS A, TZOUVELEKIS LS, TOKATLIDOU D, SPANAKIS N, MANIATIS AN, LEGAKIS NJ, TSAKRIS A. VIM-12, a novel metallo- -lactamase that ressembles a VIM-1/2 hybrid. Antimicrobial Agents and Chemotherapy 2005; 49:5153-5156.

21 4,841 90. HELMS M, LIGHFOOT D, POWLING J, BERGHOLD C, KORNSHOBER C, WYDO I, COLLARD JM, GODARD C, PRAZERES D, REIS EM, FONSECA L, FLINT J, POLLARI F, AHMED R, DEMCZUK W, HOSPEDALES J, CLARKE D, NURSE- LUCAS M, KARPISKOVA R, GERNER- SMIDT P, GILL N, O BRIEN S, THRELFALL J, SIITONEN A, LUKINMAA S, RABSCH W, TASSIOS PT, TZOUVELEKIS LS et al. International Salmonella typhimurium DT104 infections, 1992-2001. Emerging Infectious Diseases 2005; 11:859-867. µ 96 6,169 91.GIAKKOUPI P, TAMBIC-ANDRASEVIC A, VOURLI S, SKRLIN J, SESTAN-CRNEK S, TZOUVELEKIS LS, VATOPOULOS AC. Transferable DHA-1 cephalosporinase in Escherichia coli. International Journal of Antimicrobial Agents 2005; 27:77-80. 5 4,128 92.PARASKAKIS I, KAFETZIS D, CHRISAKIS A, PAPAVASILLIOU H, KIRIKOU H, PANGALIS A, TZOUVELEKIS LS, ATHANASIOU T, LEGAKIS NJ, ON BEHALF OF THE NATIONAL SURVEILLANCE NETWORK FOR PNEUMOCOCCAL RESISTANCE. Serotypes and antibiotic resistance of Streptococcus pneumoniae recovered from children in Greece during 2001-2004. Clinical Microbiology and Infection 2006; 12: 490-493. µ 10 4,540 93.VOURLI S, TSORLINI H, KATSIFA H, POLEMIS M, TZOUVELEKIS LS, KONTODIMOU A, VATOPOULOS AC. Emergence of Proteus mirabilis carrying blavim-1 metallo- -lactamase gene. Clinical Microbiology and Infection 2006; 12:691-694. 17 4,540 94. TSAKRIS A, POURNARAS S, IKONOMIDIS A, TZOUVELEKIS LS, SOFIANOU D, LEGAKIS NJ, MANIATIS AN. VIM-1 carbapenemase in Acinetobacter baumannii. Emerging Infectious Diseases 2006; 12: 981-983. 34 6,169 95.LOLI A, TZOUVELEKIS LS, TZELEPI E, CARATTOLI A, VATOPOULOS AC, TASSIOS PT, MIRIAGOU V. Sources of diversity of carbapenem resistance levels in Klebsiella pneumoniae carrying blavim-1. Journal of Antimicrobial Chemotherapy 2006; 58:669-672. 29 5,068 96. DAIKOS GL, PANAGIOTAKOPOULOU A, TZELEPI E, LOLI A, TZOUVELEKIS LS, MIRIAGOU V. Efficacy of imipenem against VIM-1-producing Klebsiella pneumoniae in a murine thigh infection model. Clinical Microbiology and Infection 2007; 13:202-205. 14 4,540 97. PANAGIOTAKOPOULOU A, DAIKOS GL, MIRIAGOU V, LOLI A, TZELEPI E, ZOUVELEKIS LS. Comparative in vitro killing of carbapenems and aztreonam against Klebsiella pneumoniae

producing VIM-1 metallo- -lactamase. International Journal of Antimicrobial Agents 2007; 29:360-362. 9 4,128 98. PAPAGIANNITSIS C, LOLI A, TZOUVELEKIS LS, TZELEPI E, MIRIAGOU V. SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. Antimicrobial Agents and Chemotherapy 2007; 51:2185-2188. 3 4,841 99. MIRIAGOU V, TZOUVELEKIS LS, FLEVARI K, TSAKIRI M, DOUZINAS EE Providencia stuartii with VIM-1 beta-lactamase. Journal of Antimicrobial Chemotherapy 2007; 60:183-184. 10 5,068 100. PAPAGIANNITSIS C, TZOUVELEKIS LS, TZELEPI E, MIRIAGOU V. Plasmid- encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrobial Agents and Chemotherapy 2007;51:3763-3767. 4 4,841 101. MAVROIDI A, PARASKAKIS I, PANGALIS A, KIRIKOU E, CHARISIADOU A, TASSIOS PT, TZOUVELEKIS LS. Spread of the Streptococcus pneumoniae Taiwan19F-14 clone among children in Greece. Clinical Microbiology and Infection 2007; 13:1213-1216. 5 4,540 102. PSICHOGIOU M, TASSIOS PT, AVLAMIS A, STEFANOU I, KOSMIDIS C, PLATSOUKA E, PANIARA O, XANTHAKI A, TOUTOUZA M, DAIKOS GL, TZOUVELEKIS LS. Ongoing epidemic of blavim-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey. Journal of Antimicrobial Chemotherapy 2007; 61:59-63. 58 5,068 103. LOLI A, TZOUVELEKIS LS, GIANNELI D, TZELEPI E, MIRIAGOU V. Outbreak of Acinetobacter baumannii with chromosomally encoded VIM-1 undetectable by imipenem-edta synergy tests. Antimicrobial Agents and Chemotherapy 2008; 52:1894-1896. 5 4,841 104. GIAKKOUPI P, VOURLI S, POLEMIS M, KALAPOTHAKI V, TZOUVELEKIS LS, VATOPOULOS AC. Supplementation of growth media with Zn2+ facilitates detection of VIM-2-producing Pseudomonas aeruginosa Journal of Clinical Microbiology 2008; 46:1568-1569. µ 6 4,153 105. ZIOGA A, WHICHARD JM, JOYCE K, TZELEPI E, TZOUVELEKIS LS, MIRIAGOU V. Evidence for chromosomal and plasmid location of CMY-2 cephalosporinase gene in Salmonella serotype Typhimurium. Journal of Antimicrobial Chemotherapy 2008; 61;1389-1390. 4

5,068 106. ZAPPAS S, GIAKKOUPI P, VOURLI S, HADJICHRISTODOULOU C, POLEMIS M, TZOUVELEKIS LS, AVLAMI A, VATOPOULOS A, DAIKOS GL, PETRIKKOS G. Epidemiology of metalloenzymeproducing Pseudomonas aeruginosa in a tertiary hospital in Greece. Journal of Chemotherapy. 2008; 20:307-311. - 1,084 107. MIRIAGOU V, DOUZINAS EE, PAPAGIANNITSIS CC, PIPERAKI E, LEGAKIS NJ, TZOUVELEKIS LS. Emergence of Serratia liquefaciens and Klebsiella oxytoca with metallo-beta-lactamase-encoding IncW plasmids: further spread of the blavim-1-carrying integron In-e541. International Journal of Antimicrobial Agents. 2008; 32:540-541. 10 4,128 108. VASILAKOPOULOU A, PSICHOGIOU M, TZOUVELEKIS LS, TASSIOS PT, KOSMIDIS C, PETRIKKOS G, ROMA ES, CHARVALOS E, PASSIOTOU M, AVLAMI A, DAIKOS GL. Prevalence and characterization of class 1 integrons in Escherichia coli of poultry and human origin. Foodborne Pathogens & Disease. 2009; 6:1211-1218. E. coli 9 2,260 109. PAPAGIANNITSIS CC, TZOUVELEKIS LS, MIRIAGOU V. Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. Antimicrobial Agents and Chemotherapy. 2009;53(1):277-280. 9 4,841 110. ZIOGA A, WHICHARD JM, KOTSAKIS SD, TZOUVELEKIS LS, TZELEPI E, MIRIAGOU V. CMY- 31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. Antimicrobial Agents and Chemotherapy. 2009; 53:1256-1259. 7 4,841 111. DAIKOS GL, PETRIKKOS P, PSICHOGIOU M, KOSMIDIS C, VRYONIS E, SKOUTELIS A, GEORGOUSI K, TZOUVELEKIS LS, TASSIOS PT, BAMIA C, PETRIKKOS G. Prospective observational study of the impact of VIM-1 metallo- -lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections. Antimicrobial Agents and Chemotherapy. 2009; 53:1868-1873. 52 4,841 112. KOTSAKIS SD, PAPAGIANNITSIS CC, TZELEPI E, TZOUVELEKIS LS, MIRIAGOU V. Extendedspectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. Antimicrobial Agents and Chemotherapy. 2009; 53:3520-3523. 3 4,841 113. GIAKKOUPI P, PAPPA O, POLEMIS M, VATOPOULOS AC, MIRIAGOU V, ZIOGA A, PAPAGIANNITSIS CC, TZOUVELEKIS LS. Emerging Klebsiella pneumoniae isolates coproducing KPC- 2 and VIM-1 carbapenemases. Antimicrobial Agents and Chemotherapy. 2009; 53:4048-4050. 32

4,841 114. MIRIAGOU V, PAPAGIANNITSIS CC, TZELEPI E, CASALS JB, LEGAKIS NJ, TZOUVELEKIS LS. Detecting VIM-1 production in Proteus mirabilis by an imipenem-dipicolinic acid double disk synergy test. Journal of Clinical Microbiology. 2010; 48:667-668. 6 4,153 115. PAPAPARASKEVAS J, TZOUVELEKIS LS, TSAKRIS A, PITTARAS TE, LEGAKIS NJ; HELLENIC TIGECYCLINE STUDY GROUP. In vitro activity of tigecycline against 2423 clinical isolates and comparison of the available interpretation breakpoints. Diagnostic Microbiology and Infectious Diseases 2010; 66:187-194. 13 2,528 116. PAPAGIANNITSIS CC, GIAKKOUPI P, VATOPOULOS AC, TRYFINOPOULOU K, MIRIAGOU V, TZOUVELEKIS LS. Emergence of Klebsiella pneumoniae of a novel sequence type (ST383) producing VIM-4, KPC-2 and CMY-4 -lactamases. International Journal of Antimicrobial Agents. 2010; 36:573-574. 12 4,128 117. KOTSAKIS SD, MIRIAGOU V, TZELEPI E, TZOUVELEKIS LS. Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES - lactamases. Antimicrobial Agents and Chemotherapy. 2010; 54:4864-4871. 5 4,841 118. MIRIAGOU V, PAPAGIANNITSIS CC, KOTSAKIS SD, LOLI A, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Sequence of pnl194, a 79.3-kilobase IncN plasmid carrying the blavim-1 metallo- lactamase gene in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 2010; 54:4497-4502. 9 4,841 119. ZIOGA A, MIRIAGOU V, TZELEPI E, DOUZINAS E, TSAKIRI M, LEGAKIS NJ, DAIKOS GL, TZOUVELEKIS LS. The ongoing challenge of acquired carbapenemases: a hospital outbreak of Klebsiella pneumoniae simultaneously producing VIM-1 and KPC-2. International Journal of Antimicrobial Agents. 2010; 36:190-191. 14 4,128 120. DAIKOS GL, VRYONIS E, PSICHOGIOU M, TZOUVELEKIS LS, LIATIS S, PETRIKKOS P, KOSMIDIS C, TASSIOS PT, BAMIAS G, SKOUTELIS A. Risk factors for bloodstream infection with Klebsiella pneumoniae producing VIM-1 metallo-beta-lactamase. Journal of Antimicrobial Chemotherapy. 2010; 65:784-788. 7 5,068 121. KOTSAKIS SD, PAPAGIANNITSIS CC, TZELEPI E, LEGAKIS NJ, MIRIAGOU V, TZOUVELEKIS LS. GES-13, a -lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2010; 54:1331-1333. 7 4,841

122. PAPAGIANNITSIS CC, TZOUVELEKIS LS, KOTSAKIS SD, TZELEPI E, MIRIAGOU V. Sequence of pr3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 -lactamases. Antimicrobial Agents and Chemotherapy. 2011; 55:376-381. 2 4,841 123. KOTSAKIS SD, TZOUVELEKIS LS, PETINAKI E, TZELEPI E, MIRIAGOU V. Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: implications on hydrolysis of expanded-spectrum cephalosporins. Proteins 2011; 79:3180-3192. 3 3,392 124. PAPAGIANNITSIS CC, KOTSAKIS SD, PETINAKI E, VATOPOULOS AC, TZELEPI E, MIRIAGOU V, TZOUVELEKIS LS. Characterization of metallo- -lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147. Antimicrobial Agents and Chemotherapy 2011; 55:3570-3572. 6 4,841 125. PAPAGIANNITSIS CC, GIAKKOUPI P, VATOPOULOS AC, TRYFINOPOULOU K, MIRIAGOU V, TZOUVELEKIS LS. Emergence of Klebsiella pneumoniae of a novel sequence type (ST383) producing VIM-4, KPC-2 and CMY-4 -lactamases. International Journal of Antimicrobial Agents 2010; 36:573-574. - 4,128 126. GIAKKOUPI P, PAPAGIANNITSIS CC, MIRIAGOU V, PAPPA O, POLEMIS M, TRYFINOPOULOU K,, TZOUVELEKIS LS, VATOPOULOS AC. An update of the evolving epidemic of blakpc-2-carrying Klebsiella pneumoniae in Greece (2009-10). Journal of Antimicrobial Chemotherapy 2011; 66:1510-1513. 30 5,068 127. PAPAGIANNITSIS CC, TZOUVELEKIS LS, KOTSAKIS SD, TZELEPI E, MIRIAGOU V. Sequence of pr3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 beta-lactamases. Antimicrobial Agents and Chemotherapy 2011; 55(1):376-381. - 4,841 128. PAPAGIANNITSIS CC, KOTSAKIS SD, PETINAKI E, VATOPOULOS AC, TZELEPI E, MIRIAGOU V, TZOUVELEKIS LS. Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147. Antimicrobial Agents and Chemotherapy 2011; 55(7):3570-3572. 1 4,841 129. MAVROIDI, A., MIRIAGOU, V., MALLI, E., STEFOS, A., DALEKOS, G.N., TZOUVELEKIS, LS, PETINAKI, E. Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 -lactamase. International Journal of Antimicrobial Agents 2012; 39 (3): 247-250. 2 4,128 130. AKOVA M, DAIKOS GL, TZOUVELEKIS LS, CARMELI Y. Interventional strategies and current

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