Solutions for Acne Prone Skin
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1 Solutions for Acne Prone Skin How to win the battle against acne-causing bacteria Dr. Sam Shefer Salvona Technologies Inc
2 Acne vulgaris Acne lesion (folliculitis) When a pore is blocked, Propionibacterium acne (an anaerobic bacterium) overgrows and secretes chemicals that blend with dead cells to form an acne lesion (folliculitis, pimple). Pimples also may include the non-pore-resident Staphylococcus epidermidis, Staphylococcus aureus. Occurs at all ages, affects 60-70% of Americans. 20% will have severe acne, which results in permanent physical damage and scarring. Affects areas most densely populated by sebaceous follicles, including the face, the upper part of the chest, and the back. P. acnes can be killed by benzoyl peroxide, tetracycline, chlorhexidine gluconate, Clindamycin. 2
3 The Acne Myth 1. What causes Acne? 2. What is the best strategy to treat acne? 3
4 Facts 1. Antibiotics treat the symptoms of acne but do not work long term. 2. Everyone has acne bacteria on their skin. 3. If you expose perfect skin to the bacteria, it would not have any negative effect. 4. If you expose acne prone skin to the bacteria, it would cause redness, swelling, and inflammation. Propionibacterium acnes grown in thioglycollate medium. Aerotolerant anaerobic gram positive bacterium (rod) that is linked to the skin condition acne. 4
5 Acne Prone Skin Hormonal changes 5
6 Comedones Oil and skin cells clog hair follicles. 6
7 Inflammation and Severe Acne Papules are comedones that become inflamed, forming small red or pink bumps on the skin. This type of pimple may be sensitive to the touch. Picking or squeezing can make the inflammation worse and may lead to scarring. A large number of papules may indicate moderate to severe acne. 7
8 Salicylic Acid (API) Exfoliating and Anti-bacterial Agent What are the challenges? 1) Not formulation-friendly: poor solubility in water. Requires alcohol/surfactants to reach OTC levels. 2) Dryness and irritation due to low ph (< 2.7). 3) Reduced efficacy, short contact time. Extracted from the inner bark of White Willow tree Properties 4) Chemically reactive in soap bars. Powder Molecular formula: C7H6O3 Density: g/cm 3 Melting point: C, 318 F Boiling point: 211 C, 412 F (20 mmhg) Solubility in water: 0.2 g/100 ml (20 C) Acidity (pka):
9 Technology Criteria Rationale: Salicylic Acid will continuously exfoliate the skin, to open the pores, and allow air to fight acne. Sub-micron spheres provide the ability to: - Encapsulate Salicylic Acid for stability and compatibility - Enable easy formulation in facial wash and leave-on products - Form a clear emulsion for facial/body washes - Time release for longer-lasting benefits - Slow release and ph control for healthy and skin-friendly condition - Cost-effective 9
10 Successful use of Salicylic Acid: Practical formulations of facial/body washes and leave-on lotions. Effective, potent acid form Enhanced deposition on skin for longerlasting effect Maintain a skin-friendly and healthy ph environment on skin (5-5.5) 10
11 SalSphere Salicylic Acid 30 Structural Characteristics Bio-adhesive polymer Salicylic Acid Hydrophobic Core ( micron) SalSphere Major Features: Water-based Results in clear emulsion Deposition Slow release Skin-friendly ph 11
12 SalSphere Salicylic Acid 30 Exfoliation of the skin Exfoliating the skin results in more air penetrating the pores and inhibit bacteria growth. 12
13 SalSphere Salicylic Acid 30 Properties Formulation-friendly Stable and clear emulsion Skin-friendly ph ( ) 13
14 SalSphere Salicylic Acid 30 - Clinical Before After (1 week) Reduced redness and irritation within 1 day. Doesn t dry the skin due to release of small dosages over longer time. Long term benefit due to longer exposure to the skin. 14
15 Salicylic Acid Technology Enhanced Efficacy of Cosmetic-Grade Consumer Use Test *!" )!" Blemish Count (%)! (!" '!" &!" %!" $!" #!"!" 0.5% MultiSal SA 30! Control! (n=57; washed 3x/day for 30 days) 15
16 SalSphere Salicylic Acid 30 Longer-lasting Salicylic Acid on Skin 120! 100! Salicylic Acid %! 80! 60! 40! 20! 0! 0! 2! 4! 6! Time (hours)! Encapsulated SA! Free SA! Extraction Method 16
17 SalSphere Salicylic Acid 30 ph Control Encapsulated SA = ph 5-6!! Free SA = ph 3! 17
18 SalSphere Salicylic Acid 30 Skin ph : In-vivo 6.00! 5.00! 4.00! Skin ph! 3.00! 2.00! 1.00! Encapsulated SA! Free SA! Untreated Skin! 0.00! 0! 1! 2! 3! 4! 5! 6! Time (Hrs.)! 18
19 SalSphere Salicylic Acid 30 Long-lasting on Skin 120! 100! Salicylic Acid %! 80! 60! 40! 20! Encapsulated SA! Free SA! 0! 0! 2! 4! 6! Time (hours)! 19
20 Proven Results 20
21 Product Compatibility 21
22 MultiSal Salicylic Acid 30 Triggered Release Shell Sub-micron Spheres 22
23 MultiSal Salicylic Acid 30 Proven Effective 23
24 MultiSal Severe Acne Multi-Symptom Relief Functional Ingredients (FI) Salicylic Acid Benzalkonium Chloride, Camellia sinensis Leaf Extract Cocamidopropyl Dimethylamine, Butyrospermum Parkii (Shea Butter) Fruit, Cera Alba, Fucus Vesiculosis (Seaweed) Extract, Palmitic Acid, Lactic Acid Camellia Sinensis Leaf Extract, Conjugated Linoleic Acid, Anthemis Nobelis (Chamomile) Flower Extract Palmitoyl Tripeptide-5, Ascorbic Acid Purpose Anti-Acne Antibacterial/Antiseptic Modulate Hydration Anti-Inflammatory Rejuvenation Hydrolyzed Corn Starch, Hydrolyzed Silica, Zinc Sulfate, Kalonite Sebum Control 24
25 Smart Delivery Systems Solutions for Acne Prone Skin Advanced technologies that allow: 1. Seamless incorporation in formulations 2. Gentle yet effective exfoliation 3. Higher deposition, targeted release, and longer-lasting benefits. 4. Increased efficacy; once a pore is opened, air will help effectively reduce acne. 5. Keeps skin healthy and clear, preserves overall healthy appearance 25
26 Thank You Contact Salvona Technologies Inc.,
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