Oswaldo Cruz Foundation F I O C R U Z
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1 Oswaldo Cruz Foundation F I O C R U Z Wim Degrave April 2015 Research Education Technological Development Production Reference Services Scientific collections Health assistance Information/Communication Planning & Management
2 DISTRIBUTION of 22 TECHNICAL UNITS In 11 States in Brazil 10 Research Institutes 3 Health Schools CPqMD Rondonia Pantanal ICC/ IBMP DIREB CEARA CPqRR PIAUI CPqGM RIO CPqAM IOC ENSP INCQS IFF COC ICICT IPEC ESPJV Biomanguinhos Farmanguinhos CECAL 2 Hospitals 3 Production Plants 1 Technological Center 1 Health History Center 1 Information Center 1 Ctr. Quality Control 1 Public Health Center
3 Research and Development at Fiocruz: Growing awareness for translational research what, where, how Collective Health Research in Public Health Biomedical Research Translational Research, Clinical Research Technological Development scale-up, Production validation Services Clinical assistance Reference services Planning Production of knowldege Scientific collections and biodiversity assets Clinical Research Reference Services Applied research Product development Production Quality control Control Biotechnology New technologies Teaching, Capacity building, information, communication, Technology management
4 VPPLR Translational R&D Programmes & Interdisciplinary Research with New Technologies PPT on Chagas, Leishmania, Schisto, Tb, emerging diseases PPT- on Chronic non-communicable diseases (cancer) PPT-Neuro: Research in Neurology and its disorders PPT-Metabolo: diseases of metabolism PPT Nanotechnology: formulations for drugs and vaccines; tools for diagnóstics ROCC- Omic technologies and Scientific Computation PI-Biosyn : Synthetic Biology; synthetic antigens for diagnostics, recombinant viruses for vaccines; enzyme engineering, synthetic antibodies, synthetic production systems.
5 Fiocruz International Cooperation Cooperation Technical cooperation D N D i IBISA Pasteur Network
6 Marketing The Innovation System at Fiocruz Research at R&D Institutes PAPES PCTIS Translational Research Fio-Tb Bio-Manguinhos Far-Manguinhos IBMP CIPBR Bio-Manguinhos Far-Manguinhos Private partners Private Partners Basic and Applied Research Pre- Development Development Preclinical Scale-up Clinical Production Universities partners
7 Tb Research at Fiocruz Group/Institute Miguel Hiijar / Carlos Basilia / Hisbello Campos Philip Suffys / IOC Fatima Fandinha / Helio Fraga / ENSP Valéria Rolla / INI Patrícia Bozza, Milton Moraes / IOC Leila M. Lima / IOC Wim Degrave Teca Galvão Haiana Charifker / CPqAM Major focus Public health, Tb observatory / Advocacy Molecular epidemiology, typing, drug resistance Microbiology, strain collections, clinical research Clinical Research Immunology, cell biology BCG, comparative genomics, bioinformatics Diagnostics, pediatric clinical practice
8 Tb Research at Fiocruz - 2 Group/Institute Major focus Marco Krieger / IBMP / Bio Diagnostics development Mauricio Barreto Margareth Dalcomo / ENSP Graça Henriques /FAR Maria Christina Lourenço - INI André Daher / FAR Marcos Nora Epidemiology, Public Health programs, vaccination studies Clinical Research Drug screening Drug screening Drug development, clinical trials Milton Moraes
9 TECNOLOGIES IN DIAGNOSTIC SYSTEMS ibmp.org.br/en/
10 New Production Capacity Important investments Strategic actions CDTS under construction IBMP Paraná: m2 GMP area for diagnostics production e development CIPBR: m2 total m2 GMP area for diagnostics production
11 Infrastructure DNA sequencing Genotyping 3730XL QuantStudio Viia 7 Ion Torrent SOLiD XL NextSeq MiSeq HiSeq 2500
12 Research and Development Interests - 1 Drugs, combination therapies and formulations for Tb treatment, clinical studies Novel diagnostic systems (PCR-rt, sensors, nanotechnology, microfluidics, microchips for detection and drug resistance) Strain collections and biobanking; Omics; antigen studies, vaccine models, drug resistance, molecular epidemiology PPD development Computational modeling for vaccine and treatment studies Training, capacity building
13 Research and Public Health Interests - 2 Studies and modeling on social and environmental determinants of Tb Vulnerable populations and complementary interventions Studies on the impact / eficacy of programs and interventions Matematical models and geo-referencing Advocacy, communication and social mobilization
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