Proton Therapy Essentials

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1 Proton Therapy Essentials An Architect s Perspective Presented By: Tsoi/Kobus & Associates Architects: Erik Mollo-Christensen, AIA Principal Jonathan Cohen, AIA Associate Principal

2 Proton Therapy Essentials An Architect s Perspective Objectives: 1. Overview What is Proton Therapy? Advantages Demand/Availability Opportunities/Challenges 2. Anatomy of a PT Facility Physical requirements Design flexibility A Healing Environment Planning considerations

3 Introduction Tsoi/Kobus & Associates (TK&A) offers nearly 20 years of experience in proton therapy facility planning and design Experience with: Cancer Centers Operating proton therapy facilities Planned proton therapy facilities Proton equipment manufacturers Academic and private proton therapy facilities Erik Mollo-Christensen, Principal Building long-term relationships 3-D modeling and design Jonathan Cohen, Associate Principal

4 1. Overview What is Proton Therapy? Advantages Demand/Availability Opportunities/Challenges

5 What is Proton Therapy? Form of radiation treatment using protons Large and specialized equipment Multi-room facilities 50-90,000 FT 2 $ MM project cost Complex and integrated processes Finance Design/construction Physics Medicine

6 What is Proton Therapy? Form of radiation treatment using protons Large and specialized equipment Multi-room facilities 50-90,000 FT 2 $ MM project cost Complex and integrated processes Finance Design/construction Physics Medicine Cyclotron accelerator Synchrotron accelerator

7 Clinical Advantages Higher dose with greater precision (tissue sparing) Reduced morbidity / side-effects Demonstrated effectiveness on cancer of the eye, head, neck, CNS, prostate, pediatric cancers Protons release their energy in a narrowly defined range Procure Treatment Center, Oklahoma City

8 Perceived Demand for Proton Therapy Significant and unmet need for Protons Especially for children Clinical role for PT remains controversial

9 Perceived Demand for Proton Therapy Significant and unmet need for Protons Especially for children Clinical role for PT remains controversial

10 Current Availability for Proton Therapy 1991 Loma Linda (U.S.) operating centers 4 under/construction +/- 25 centers worldwide Access remains limited (+/- 50,000 patients treated world-wide) Many centers announced/few built

11 Challenges to Adoption Financial/Regulatory High first cost/operating cost Financing CMS/Reimbursement coverage rate Political environment/healthcare reform

12 Challenges to Adoption Technical Limited Vendors/FDA and CE approval Equipment/Software not mature End user responsible for integration

13 Challenges to Adoption Clinical Slow facility ramp-up (not meeting business plan targets) Reliance on low-risk prostate cases Limited evidencephysician skepticism Lack of trained staff Clinicians Physicists Dosimetrists Radiation therapists

14 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

15 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

16 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule Still River Systems Monarch 250

17 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule IBA Proteus Nano

18 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule Compact Synchrotron, ProTom International

19 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) - 39 months Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

20 Opportunities Lowering costs/ Reducing uncertainty Clinical expansion of reimbursable treatment sites (breast, lung, pancreas) - 30 months Evolving Technologies adapting on the fly Increased Vendor Competition Smaller scale/single room systems Third party development Design and construction schedule

21 2. Anatomy of a PT Facility Physical Requirements Design Flexibility A Healing Environment Planning Considerations

22 What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities CT Exam

23 What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities

24 What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities Gantry ~ tons

25 What are the Physical requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities

26 What are the Physical Requirements? Basic facility Diagram Large scale not a Linac Radiation Shielding & Geometry Building/equipment interface Stringent Design Requirements Loads Tolerances M/E Utilities

27 Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal

28 Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Integrated Facility

29 Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Free standing facility

30 Designing for Flexibility Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Proton Perelman Center for Advanced Medicine

31 Designing for Flexibility Designing for Flexibility Facility Scale Integrated vs. free-standing facilities Expansion & Phasing Installation Access & Removal Cyclotron installation Gantry cage removal

32 A Healing Environment Self-referred patient base Outpatient treatment Efficiency/Throughout Two recent examples: - ProCure Treatment Center Oklahoma City, OK - Roberts Proton Therapy Center Philadelphia, PA

33 A Healing Environment Procure Treatment Center, Oklahoma City, OK

34 A Healing Environment

35 A Healing Environment

36 A Healing Environment

37 A Healing Environment

38 A Healing Environment Roberts Proton Therapy Center, Philadelphia, PA Raphael Vińoly Architects Perkins Eastman Tsoi/Kobus & Associates

39 A Healing Environment

40 A Healing Environment

41 A Healing Environment

42 A Healing Environment

43 Planning Considerations Clinical model/program Business model Site selection Team selection Equipment vendor Radiation physicist A/E team Builder Experience counts!

In 1946 Harvard physicist Robert Wilson (1914-2000) suggested:

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