Discover the power of your newborn s cord blood.

Transcription

1 Discover the power of your newborn s cord blood.

2 What s so special about your newborn s cord blood? Your baby s umbilical cord blood is a valuable source of noncontroversial stem cells. Cord blood stem cells, like bone marrow stem cells, are free of political and ethical debate. The benefits of cord blood stem cells are clear cord blood has already saved thousands of lives and medical researchers are now exploring potential new uses for conditions like diabetes, heart disease and stroke. We encourage you to read more about this remarkable gift of nature and make an informed decision for your family. 1

3 Cord Blood Overview 2

4 Stem Cells: The New Era in Medicine Unlike most conventional medicines that treat symptoms, cellular medicines focus on correcting and/or replacing diseased or damaged cells. Stem cells are the building blocks of organ tissue, blood and the immune system. Stem cells can also turn into other types of cells including heart, muscle and nerve cells. Heart Cells Stem Cell Blood Cells Liver Cells Pancreatic Cells Nerve Cells T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M 3

5 Future Potential of Stem Cells Alzheimer s Disease 10% of those over age 65 will develop Alzheimer s, which currently includes 4.5 million Americans. Stroke Every 45 seconds, someone in America has a stroke. Every 3 minutes, someone dies from stroke. Heart Disease The leading cause of death in U.S. (1 million every year) Currently, 12.6 million Americans suffer from Heart Disease. Lou Gehrig s Disease (ALS) Every year, 10,000 new cases are diagnosed in the U.S. Once diagnosed, a patient s life-expectancy ranges from 3 to 5 years. Muscular Dystrophy 20,000-50,000 people are affected by Muscular Dystrophy annually. Liver Disease 25 million Americans (1 in 12) are or have been afflicted with liver and biliary diseases. Up to 50% have no symptoms and the first sign of liver disease may be an abnormal blood test. Bone Regeneration Osteoporosis is a major public health threat for an estimated 44 million Americans, or 55% of people age 50 and older. Skin & Tissue Regeneration for Burn Victims 80% of all burn injuries occur at home, primarily to children (250,000 per year). Burns are the leading cause of accidental death in children under the age of 2. Spinal Cord Injuries 243,000 Americans suffer from spinal cord injuries. Over 40% of all cases are caused by vehicle accidents. Health care costs and living expenses can run as high as $600,000 in the first year and $112,000 in subsequent years. Diabetes In the U.S. alone, 16 million people suffer from Diabetes and it is the 7th leading cause of death. Multiple Sclerosis An estimated 400,000 Americans are afflicted with MS. The cause is still unknown and relatives of affected people are 8 times more likely to contract the disease. Disease statistics based on data acquired in Research into the ability of stem cells to treat these diseases is experimental. Cord blood stem cells may never be proven to be effective treatments for these diseases. 4 T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M

6 Cord Blood: A Premier Source of Stem Cells Your baby s cord blood stem cells are a valuable potential medical resource for your baby and family. These valuable cord blood stem cells, like the stem cells found in bone marrow, are non-controversial and free of political and ethical debate surrounding other types of stem cells. Here s what we know about cord blood stem cells today: Cord blood stem cells are now used to treat over 70 life-threatening diseases including many cancers. A baby s cord blood stem cells have the potential to be used for the baby, siblings and other family members. A stem cell transplant using cells from the family is recognized as the best treatment option. Transplants from a family member have twice the success rate as transplants using donated cells from outside the family.* Cord blood stem cells are being researched as potential treatment options for many diseases including diabetes and heart disease. *Gluckman, et al., New England Journal of Medicine 1997, pp T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M 5

7 Advancements in Cord Blood Stem Cells Diseases treatable with cord blood 1 70+? Number of cord blood transplants 1 10,000? Number of family cord blood units banked 0 600,000+? Lifetime probability (by age 70) of undergoing a stem cell transplant* 1 in 1,700, in 217? There are a number of things we know that make cord blood valuable and there are things that we can only predict that it will be used for in the future, but right now there are things called stem cells which are building-block cells that can become anything so in the future, if a baby needs certain transplants, like say, for bone marrow for leukemia. There are a lot of things that we don t even know yet that they could be used for. The U.S. Surgeon General, Vice Admiral Richard H. Carmona, M.D., M.P.H., F.A.C.S. from an interview on the Discovery Health Network *Statistics based on Nietfeld JJ et al. Biol Blood Marrow Transplantation. 2008;14: Assumes a constant utilization rate (17%) for undergoing a stem cell transplant. Cord Blood stem cell research to treat additional diseases is experimental. The number of diseases treatable with such stem cells may not increase as rapidly in the future ViaCord. 6 T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M

8 Diseases Currently Treated With Cord Blood Stem Cells Below is a list of over 70 diseases that have been treated with cord blood stem cells.* However, this list continues to grow as research advances. Cancers Acute lymphoblastic leukemia (ALL) Acute myeloid leukemia (AML) Burkitt s lymphoma Chronic myeloid leukemia (CML) Juvenile myelomonocytic leukemia (JMML) Hemophagocytic lymphohistiocytosis Non-Hodgkin s lymphoma Hodgkin s lymphoma Langerhan s cell histiocytosis Lymphomatoid granulomatosis Myelodysplastic syndrome (MDS) Chronic myelomonocytic leukemia (CMML) Bone Marrow Failure Syndromes Amegarakyocytic thrombocytopenia Autoimmune neutropenia (severe) Congenital dyserythropoietic anemia Cyclic neutropenia Diamond-Blackfan anemia Evan s syndrome Fanconi anemia Glanzmann s disease Juvenile dermatomyositis Kostmann s syndrome Red cell aplasia Schwachman syndrome Severe aplastic anemia Congenital sideroblastic anemia Thrombocytopenia with absent radius (TAR syndrome) Dyskeratosis congenita Blood Disorders/Hemoglobinpathies Sickle-cell anemia (hemoglobin SS) HbSC disease Sickle ߺ Thalassemia a-thalassemia major (hydrops fetalis) ß-thalassemia major (Cooley s anemia) ß-thalassemia intermedia E-ߺ thalassemia E-ß+ thalassemia Metabolic Disorders Adrenoleukodystrophy Gaucher s disease (infantile) Metachromatic leukodystrophy Krabbe disease (globoid cell leukodystrophy) Gunther disease Hermansky-Pudlak syndrome Hurler syndrome Hurler-Scheie syndrome Hunter syndrome Sanfilippo syndrome Maroteaux-Lamy syndrome Mucolipidosis Type II, III Alpha mannosidosis Neumann Pick Syndrome, type A and B Sandoff Syndrome Tay Sachs Disease Batten disease (inherited neuronal ceroid lipofuscinosis) Lesch-Nyhan disease Immunodeficiencies Ataxia telangectasia Chronic granulomatous disease DiGeorge syndrome IKK gamma deficiency Immune dysregulation polyendocrineopathy X-linked Mucolipidosis, Type II Myelokathesis X-linked immunodeficiency Severe combined immunodeficiency Adenosine desaminase deficiency Wiskott-Aldrich syndrome X-linked agammaglobulinemia X-linked lymphoproliferative disease Omenn s syndrome Reticular dysplasia Thymic dysplasia Leukocyte adhesion deficiency Other Osteopetrosis *Although the potential use of umbilical cord blood is expanding rapidly, the odds that a family member without one of these diseases will need to use their child s cord blood are low. There is no guarantee that the umbilical cord blood will be a match for a family member or will provide a cure. Autologous cord blood stem cells will not guarantee suitable treatment for all inherited genetic diseases. As with any transplant therapy, therapeutic success depends upon many factors beyond the stem cells themselves including patient condition, type of disease, recipient-donor relationship and matching, and other factors. T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M 7

9 A real life story of cord blood helping families. Geoff and Amber Patrick of Henderson, NV were blessed with 2 beautiful girls Paris and Taylor. Life couldn t have been better. That was, until Taylor was diagnosed with leukemia and needed a stem cell transplant. After searching for a suitable donor, the best candidate turned out to be her older sister, Paris. Taylor and Paris underwent the painful but necessary bone marrow stem cell transplant which sent the Leukemia into remission. The Patrick s life returned to normal and in November of the following year, they were blessed with a third beautiful daughter, Trinity. Because of what they had been through with Taylor, they decided to preserve Trinity s cord blood stem cells with ViaCord, just in case. Two years later, that simple decision turned out to be a life-saver for Taylor. Her Leukemia came back and her best chance for success was a cord blood stem cell transplant. A transplant was scheduled and occurred in March, Today, Taylor is a happy, healthy little girl thanks to a seemingly simple decision by her parents to preserve her sister s cord blood with ViaCord. To view a video of the Patrick Family story and others, visit: Individual results may vary. Although the potential use of cord blood is expanding rapidly, the odds that a family member without a disease currently treatable with cord blood stem cells will need to use their child s cord blood are low. There is no guarantee that the cord blood will be a match for a family member or will be an appropriate or effective treatment. 8 T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M

10 ViaCord s Banking Service ViaCord: The Cord Blood Experts ViaCord has been a cord blood leader for over 15 years. ViaCord is also a recognized leader in cord blood research. We re dedicated to finding new treatments using cord blood stem cells. 9

11 ViaCord s Cord Blood Collection & Processing Expertise Collection Expertise Only families choosing ViaCord have access to the Cell Sentinel TM Collection Bag The only FDA-Approved collection bag for use in a sterile field required for C-sections. Did you know... Approximately 30% of all babies are delivered by C-section. ViaCord s Cell Sentinel TM Cord Blood Collection Bag ViaCord s Cell Sentinel TM is the only cord blood collection bag that is FDA-approved and designed for use in C-section deliveries. Processing Expertise Only families choosing ViaCord have access to the expertise that comes from processing over 185,000 cord blood units in a Closed Processing System. Each cord is processed by professionals trained in preparing stem cell samples for transplant. Our state-of-the art processing laboratory is the first Family Bank to utilize FDA-cleared automated processing technology. The quality of our processing is demonstrated by our extensive history of cord blood transplants (please refer to insert for a complete listing of our transplant history) T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M 10

12 ViaCord s Cord Blood Testing & Storage Expertise Testing Expertise ViaCord uses an advanced, FDA-cleared microbial detection system designed to provide transplant physicians with the information required for appropriate treatment. Storage Expertise ViaCord s Processing Laboratory is a privately owned, state-of-the-art cord blood cryopreservation facility located just outside of Cincinnati. It is solely dedicated to processing and storing your baby s cord blood. ViaCord s state-of-the-art Processing Laboratory is AABB-accredited, CLIA-certified and FDA-registered, and staffed by professionals trained in preparing stem cell samples for transplant. Our experience and expertise shows in our proven history of long-term cryobag storage and that we have now processed and stored the cord blood of over 185,000 newborns. 11 T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M

13 ViaCord: The Cord Blood Experts ViaCord has processed over 185,000 units in a Closed Processing System. 12

14 A real life story of cord blood helping families. The Cannon family s pediatrician said it was just a stomach virus and that 5 yr. old Tyrone would soon be himself again. But when his illness worsened, further diagnosis revealed the tragic news that Tyrone had developed aplastic anemia. The Cannon s began to research drug treatment options, but quickly discovered that many of these options came with adverse side effects. Then, while watching TV one day, they saw a ViaCord commercial about preserving a newborn s cord blood stem cells. Since Tyrone s mother was expecting again, they decided to call ViaCord. Four months later, they gave birth to their daughter, Sania, and discovered her cord blood stem cells were a perfect match for Tyrone. A transplant was scheduled on December 16, 2005 and Tyrone was infused with less than an ounce of his new sister s cord blood stem cells. Today, Tyrone s aplastic anemia is now in complete remission. For the Cannon family, what began with one simple phone call, turned out to be one of the smartest decisions they ever made. To view video of this story and of other ViaCord success stories, visit: Individual results may vary. Although the potential use of cord blood is expanding rapidly, the odds that a family member without a disease currently treatable with cord blood stem cells will need to use their child s cord blood are low. There is no guarantee that the cord blood will be a match for a family member or will be an appropriate or effective treatment. 13

15 ViaCord Research Institute Through the ViaCord Research Institute (VRI), we are focused on developing potential new uses for cord blood. VRI s mission to support science, technology and medical treatments using cord blood stem cells affirms our commitment to increase the value of cord blood to families. Our collaborations and support efforts also reflect our commitment to advancing science and to our families. ViaCord s Collaborators M.D. Anderson Cancer Center The ViaCord Research Institute and The University of Texas M.D. Anderson Cancer Center research collaboration is focusing on cord blood stem cell expansion system in adult transplantation. The study seeks to develop a method of treating more adults using cord blood stem cells. M. D. Anderson s Clinical Research Trial explores ViaCord s Co-Culture Expansion Technology, which may make it possible to use stem cells to treat even more patients by increasing the total number of stem cells available from a single cord blood unit. Pfizer Pfizer, the world s largest research-based biomedical and pharmaceutical company, will use ViaCord s proprietary Unrestricted Somatic Stem Cell lines in a platform for screening small molecules that impact the renewability, differentiation and function of stem cells. This work is anticipated to provide valuable insight into stem cell regeneration, which may ultimately lead to drugs and/or cell-based products that regenerate damaged or diseased tissues in the body. The University of Massachusetts Medical School The ViaCord Research Institute will support the University of Massachusetts Medical School in its research efforts into the potential use of umbilical cord blood-derived stem cells in treating type 1 diabetes. Type 1 diabetes, which accounts for between five and ten percent of all diagnosed cases of diabetes, is an autoimmune disease, that occurs most often in children and young adults. T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M 14

16 ViaCord The Cord Blood Experts In addition to our quality cord blood banking service and continued commitment to research, there are several other reasons why ViaCord is a proven cord blood leader: FDA-registered, AABB-accredited and CLIA-certified The only cord blood collection bag that is FDA-approved for use in a sterile operating field (C-section deliveries) Proven history of delivering viable units for transplant ViaCord s Quality Product Guarantee The ViaCord Gift Registry makes it easy for family and friends to participate in this valuable gift for your newborn To learn more, call toll-free to speak with one of our clinical consultants, available 24-7: T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M 15

17 ViaCord s Comprehensive Service Our comprehensive service takes care of every detail so you can focus on more important things like enjoying the first precious moments with your newborn. 1. Enroll. Enrolling with ViaCord couldn t be simpler. Just call one of our consultants or enroll on-line. No payment is due until the time of delivery. 4. Bedside pick-up by private courier. A private courier picks up your baby s cord blood from your hospital room and delivers it directly to our laboratory. 2. Bring kit to hospital. Soon after you enroll, you ll receive ViaCord s Collection Kit. Keep it with your pre-packed hospital luggage as a reminder to bring it along. Call our 24/7 hotline in route to the hospital. 5. Processing & cryopreservation. Our state-of-the-art laboratory utilizes the most advanced science and technology to maximize the quality of your baby s cord blood stem cells Call ViaCord after you give birth. After you give birth, the stem cell rich blood is collected from the cord in a simple 2-4 minute procedure. Then, just call us and we ll handle all the transportation logistics. Long Term Storage. You ll receive a certificate of cryopreservation from us letting you know your baby s cord blood is safely stored at our laboratory. T A L K T O T H E C O R D B L O O D E X P E R T S : W W W. V I A C O R D. C O M

18 ViaCord + CHORI*: Proven History of Safe and Effective Units for Transplant Transplants Disease Treated Chemo/ Radiation Required Facility Date of Use Donor Relationship Recipient Age (yrs) Time Stored (months) Engraftment Time (Days) Processed By: Cord Volume Collected (ml) Nucleated Cell Count (x10 8 ) Total CD34+ Cells (x10 6 ) Acute Lymphoblastic Leukemia Y University of Miami 6/20/96 Sibling ViaCord Severe Aplastic Anemia Y Duke University Medical Center 9/19/97 Sibling CHORI N/A Wiskott Aldrich Syndrome Y Fred Hutchinson Cancer Research Center 11/14/97 Sibling ViaCord Acute Myelogenous Leukemia Y Rush University Medical Center 12/24/97 Sibling 4 <1 13 ViaCord Thalassemia Major Y University of California San Francisco Medical Center 6/4/98 Sibling CHORI Thalassemia Major Y University of Chicago Medical Center 12/23/98 Sibling CHORI Fanconi Anemia Y Johns Hopkins 6/15/99 Sibling ViaCord SKID/ Myelodysplastic Syndrome Y Oregon Health & Science University 9/7/99 Sibling CHORI Sickle Cell Disease Y Hackensack University Medical Center 9/22/99 Sibling CHORI Sickle Cell Anemia Y St. Jude Children's Research Hospital 2/02/00 Sibling ViaCord Sickle Cell Disease Y University of North Carolina 5/11/00 Sibling CHORI Thalassemia Major Y Children's Memorial Hospital, Chicago 6/8/00 Sibling CHORI Sickle Cell Disease Y Lucile Packard Children's Hospital 7/14/00 Sibling 4 25 N/A CHORI Thalassemia Major Y Children's Hospital of Orange County 10/4/00 Sibling CHORI Severe Aplastic Anemia Y Children's Hospital and Research Center Oakland 10/6/00 Sibling CHORI Acute Myelogenous Leukemia Y Fairview University Medical Center 11/17/00 Sibling 3 4 N/A CHORI Thalassemia Major Y Miami Children's Hospital 12/14/00 Sibling ViaCord Thalassemia Major Y Duke University Medical Center 12/14/00 Sibling CHORI Severe Aplastic Anemia Y Mount Sinai Hospital 4/02/01 Autologous (Self) ViaCord Severe Aplastic Anemia Y Memorial Sloan-Kettering Cancer Center 6/27/01 Sibling ViaCord Acute Lymphoblastic Leukemia Y Johns Hopkins 7/13/01 Sibling CHORI Sickle Cell Disease Y The Jimmy Everest Ctr. for Cancer & Blood Disorders in Children 11/2/01 Sibling CHORI Thalassemia Major Y Hackensack University Medical Center 11/29/01 Sibling CHORI Sickle Cell Disease Y Hackensack University Medical Center 12/7/01 Sibling CHORI Neuroblastoma Y Texas Children's Hospital 12/11/01 Autologous (Self) ViaCord Acute Lymphoblastic Leukemia Y Johns Hopkins 1/17/02 Sibling CHORI Thalassemia Major Y Children's Hospital and Research Center Oakland 2/1/02 Sibling CHORI Fanconi Anemia Y Fairview University Medical Center 4/23/02 Sibling ViaCord Chronic Granulomatous Disease Y Hackensack University Medical Center 4/25/02 Sibling 6 13 N/A1 ViaCord Acute Myelogenous Leukemia Y University of California San Francisco Medical Center 6/11/02 Sibling CHORI Sickle Cell Disease Y Texas Transplant Institute 7/23/02 Sibling CHORI Acute Myelogenous Leukemia Y University of Nebraska Medical Center 7/24/02 Sibling 4 3 N/A CHORI Acute Myelogenous Leukemia Y Children's Hospital and Research Center Oakland 8/5/02 Sibling CHORI (IPEX) Immune dysregulation, polyendocrinopathy, enteropathy, X-linked Y Fred Hutchinson Cancer Research Center 9/3/02 Sibling CHORI Sickle Cell Disease Y Memorial Sloan-Kettering Cancer Center 10/10/02 Sibling CHORI Acute Lymphoblastic Leukemia Y Lucile Packard Children's Hospital 11/4/02 Sibling CHORI Acute Myelogenous Leukemia Y Texas Transplant Institute 12/27/02 Sibling CHORI Myelodysplastic Syndrome Y University of Mississippi Medical Center 1/6/03 Sibling CHORI Acute Lymphoblastic Leukemia Y Oregon Health & Science University 1/24/03 Sibling CHORI Acute Myelogenous Leukemia Y New York Presbyterian Hospital 3/4/03 Sibling CHORI Acute Lymphoblastic Leukemia Y Oregon Health & Science University 5/13/03 Sibling CHORI *Children s Hospital Oakland Research Institute 1 Engraftment occurred with a follow up stem cell transplant using bone marrow from the same sibling. The patient experienced autologous hematopoietic recovery. P-TX-MED-1008

19 Transplants (cont.) Disease Treated Chemo/ Radiation Required Facility Date of Use Donor Relationship Recipient Age (yrs) Time Stored (months) Engraftment Time (Days) Processed By: Cord Volume Collected (ml) Nucleated Cell Count (x10 8 ) Total CD34+ Cells (x10 6 ) Thalassemia Major Y San Francisco General Hospital 5/15/03 Sibling CHORI Severe Aplastic Anemia Y Dana-Farber Cancer Institute 5/29/03 Sibling CHORI Acute Lymphoblastic Leukemia Y Fred Hutchinson Cancer Research Center 6/17/03 Sibling CHORI Sickle Cell Disease Y Medical University of South Carolina 6/26/03 Sibling CHORI Diamond- Blackfan Anemia Y Dana-Farber Cancer Institute 8/8/03 Sibling CHORI Acute Lymphoblastic Leukemia Y Cincinnati Children's Hospital 8/19/03 Sibling CHORI Fanconi Anemia Y Cincinnati Children's Hospital 8/29/03 Sibling 5 80 N/A2 ViaCord Acute Lymphoblastic Leukemia Y Riley Hospital for Children 9/2/03 Sibling CHORI Wiskott Aldrich Syndrome Y Penn State Hershey Medical Center 10/22/03 Sibling CHORI Hurler Syndrome Y University of Louisville Hospital 11/28/03 Sibling CHORI Thalassemia Major Y Children's Hospital and Research Center Oakland 12/10/03 Sibling CHORI Acute Lymphoblastic Leukemia Y Children's Hospital of Denver 12/24/03 Sibling CHORI Sickle Cell Anemia Y Columbia-Presbyterian Medical Center 1/22/04 Sibling ViaCord Acute Myelogenous Leukemia Y Primary Children's Medical Center 2/3/04 Sibling 2 4 N/A CHORI Thalassemia Major Y Hackensack University Medical Center 8/6/04 Sibling CHORI Thalassemia Major Y University of California San Francisco Medical Center 9/29/04 Sibling CHORI Ectodermal Dysplasia Y Dana-Farber Cancer Institute 10/29/04 Sibling ViaCord Thalassemia Major Y All Children's Hospital 11/5/04 Sibling CHORI Thalassemia Major Y Children's Hospital and Research Center Oakland 12/9/04 Sibling CHORI Thalassemia Major Y Memorial Sloan-Kettering Cancer Center 12/30/04 Sibling CHORI Thalassemia Major Y Duke University Medical Center 1/5/05 Sibling CHORI Thalassemia Major Y University of Michigan Medical Center 1/21/05 Sibling CHORI Fanconi Anemia Y Cincinnati Children's Hospital 1/27/05 Sibling ViaCord Kostmann s Syndrome Y Children's Hospital of Pittsburgh 3/17/05 Sibling CHORI Thalassemia Major Y Children's Memorial Hospital, Chicago 3/17/05 Sibling CHORI Acute Myelogenous Leukemia Y University Medical Center, Tuscan AZ 3/22/05 Sibling ViaCord Acute Myelogenous Leukemia Y Children's Hospital and Research Center Oakland 5/31/05 Sibling CHORI Acute Lymphoblastic Leukemia Y Univiversity of California Davis Medical Center 6/28/05 Sibling CHORI Sickle Cell Disease Y Children's Hospital and Research Center Oakland 7/21/05 Sibling CHORI Thalassemia Major Y Children's Memorial Hospital, Chicago 7/21/05 Sibling CHORI Thalassemia Major Y Children's Hospital and Research Center Oakland 9/1/05 Sibling CHORI Sickle Cell Anemia Y University of Mississippi Medical Center 9/28/05 Sibling ViaCord Adrenoleukodystrophy Y Duke University Medical Center 10/13/05 Sibling ViaCord Sickle Cell Disease Y University of Mississippi Medical Center 10/19/05 Sibling CHORI Severe Aplastic Anemia Y New York Medical Center 12/23/05 Sibling ViaCord Acute Lymphoblastic Leukemia Y Kapiolani Medical Center 1/11/06 Sibling CHORI Myelodysplastic Syndrome Y Children's Hospital of Philadelphia 3/10/06 Sibling CHORI Thalassemia Major Y University of Florida-Shands 3/30/06 Sibling CHORI Acute Lymphoblastic Leukemia Y University of Florida-Shands 4/7/06 Sibling CHORI Acute Lymphoblastic Leukemia Y Duke University Medical Center 5/2/06 Sibling CHORI Shwachman-Diamond Anemia Y Cincinnati Children's Hospital 5/11/06 Sibling CHORI Sickle Cell Disease Y Medical College of Virginia Hospital 5/19/06 Sibling CHORI Sickle Cell Disease Y Texas Children's Hospital 6/21/06 Sibling CHORI Thalassemia Major Y Hackensack University Medical Center 8/30/06 Sibling CHORI Sickle Cell Disease Y Morgan Stanley Children's Hospital of New York Presbyterian 9/27/06 Sibling CHORI Acute Myelogenous Leukemia Y UCLA 10/20/06 Sibling ViaCord Acute Myelogenous Leukemia Y Riley Hospital for Children 12/08/06 Sibling ViaCord Engraftment occurred with a follow up bone marrow transplant 28 days later from the same sibling. P-TX-MED-1008

20 Transplants (cont.) Disease Treated Chemo/ Radiation Required Facility Date of Use Donor Relationship Recipient Age (yrs) Time Stored (months) Engraftment Time (Days) Processed By: Cord Volume Collected (ml) Nucleated Cell Count (x10 8 ) Total CD34+ Cells (x10 6 ) Sickle Cell Anemia Y Mount Sinai Hospital 1/18/07 Sibling ViaCord Sickle Cell Disease Y Children's Hospital-Philadelphia 1/19/07 Sibling CHORI Acute Myelogenous Leukemia Y Columbus Children's Hospital 1/25/07 Sibling ViaCord Severe Congenital Neutropenia Y Schneider Children's Hospital 2/08/07 Sibling ViaCord Thalassemia Major Y Children's Hospital and Research Center Oakland 2/9/07 Sibling CHORI Acute Lymphoblastic Leukemia Y Children's Memorial Hospital, Chicago 3/13/07 Sibling CHORI Brain Cancer Y Miami Children's Hospital 3/29/07 Autologous (Self) 9 mos ViaCord Acute Lymphoblastic Leukemia Y Duke University Medical Center 4/3/07 Sibling CHORI Sickle Cell Disease Y Nemours-Florida 4/18/07 Sibling CHORI Acute Lymphoblastic Leukemia Y University of North Carolina 5/16/07 Sibling CHORI Severe Combined Immune Deficiency Y Cincinnati Children's Hospital 6/04/07 Sibling ViaCord Severe Aplastic Anemia Y Children's Hospital of Wisconsin 6/08/07 Sibling ViaCord Acute Lymphoblastic Leukemia Y University of Michigan Health System 6/21/07 Sibling ViaCord Chronic Granulomatous Disease Y University of Rochester Medical Center 6/22/07 Sibling 5 9 N/A ViaCord Sickle Cell Anemia Y Children's Hospital of New York- Presbyterian 9/05/07 Sibling ViaCord Sickle Cell Anemia Y Miami Children's Hospital 9/06/07 Sibling ViaCord Sickle Cell Disease Y Duke University Medical Center 10/11/07 Sibling CHORI Severe Aplastic Anemia Y University of Minnesota Children's Hospital 10/30/07 Sibling ViaCord Thalassemia Major Y City of Hope 12/20/07 Sibling ViaCord Acute Lymphoblastic Leukemia Y Dana-Farber Cancer Institute 1/04/08 Sibling ViaCord Thalassemia Major Y University of Michigan Medical Center 5/01/08 Sibling CHORI Thalassemia Major Y University of California, San Francisco 5/29/08 Sibling 5 7 Pending* ViaCord Sickle Cell Disease Y Children's Hospital of Atlanta 7/03/08 Sibling 2 7 Pending* ViaCord Acute Myelogenous Leukemia Y All Children's Hospital 7/25/08 Sibling 2 2 Pending* ViaCord Acute Lymphoblastic Leukemia Y Dana-Farber Cancer Institute 8/15/08 Sibling 6 23 Pending* ViaCord Sickle Cell Disease Y Schneider Children's Hospital 8/15/08 Sibling 9 91 Pending* CHORI *Transplant results are not reported until at least post 100 days after transplant date. Increasing the Potential Uses of Cord Blood Infusions- Emerging Treatments Disease Treated** Chemo/ Radiation Required Facility Date of Use Donor Relationship Recipient Age (yrs) Time Stored (months) Engraftment Time Processed By: Cord Volume Collected (ml) Nucleated Cell Count (x108) Total CD34+ Cells (x106) Dysgenesis of the corpus callosum N Duke University Medical Center 3/20/07 Autologous (Self) 1 17 N/A ViaCord Type 1 Diabetes N University of Florida- Shands 3/23/07 Autologous (Self) N/A ViaCord Traumatic Brain Injury N Miami Children's Hospital 6/04/08 Autologous (Self) 4 44 NA ViaCord Traumatic Brain Injury N Santa Rosa 6/26/08 Autologous (Self) 4 44 NA ViaCord Cerebral Palsy N Duke University Medical Center 7/01/08 Autologous (Self) 2 23 NA ViaCord Cerebral Palsy N Duke University Medical Center 7/15/08 Autologous (Self) 7 mo 8 NA ViaCord Cerebral Palsy N Duke University Medical Center 7/15/08 Autologous (Self) 2 21 NA ViaCord Cerebral Palsy N Duke University Medical Center 8/05/08 Autologous (Self) 6 73 NA CHORI Type 1 Diabetes N University of Florida-Shands 8/08/08 Autologous (Self) 5 64 NA ViaCord Cerebral Palsy N Duke University Medical Center 9/16/08 Autologous (Self) 1 16 N/A ViaCord **Cord blood stem cell research to treat these additional diseases is experimental. These diseases are not on the list of diseases currently considered to be treated with cord blood stem cells and may never be considered to be diseases that can be effectively treated with cord blood stem cells. The odds are relatively low that cord blood you elect to store will be used to treat a family member. P-TX-MED-1008

21 The ViaCord Gift Registry During this special time, friends and family members will want to buy gifts to help you prepare for your new baby. That s why we created The ViaCord Gift Registry. It s a convenient way to invite your friends and family to help you pay for this service as a truly unique baby gift one that will last a lifetime. The ViaCord Gift Registry is also a convenient way to involve grandparents, baby shower organizers and guests in your decision to preserve your child s cord blood. To learn more, visit or call We look forward to assisting you with this new adventure. PP-GR-V2

22 P R I C I N G ViaCord SERVICE AND FEE OVERVIEW ViaCord does not require an up-front deposit fee which means you can enroll today and enjoy the comfort of knowing you won t have to make any payments until you deliver. Save $125 when you pay in full or select our 6-month payment plan: Payment Options Processing and Private Courier 1st Year Storage Payment Savings Pay In Full at the time of delivery $2070 $125 $2195 Save $125 6-month Payment Plan $2070 $125 $366/month Save $125 OR Take advantage of one of our convenient and affordable payment plans: Payment Plan Options Payment Details Included 48-Month Baby Steps Plan 12-Month Flexible Plan $64 per month No payments until 4 months after delivery $194 per month Payments start at delivery Includes Processing, Private Courier and 1st Year Storage Annual Storage Fee: $125 annual storage fee. This fee covers the long-term cryogenic storage of your baby s cord blood stem cells at VPL, ViaCord s state-of the-art cord blood processing and cryopreservation facility. Storage Prepayment Options: We also offer Storage Prepayment Options at significant savings versus our standard annual storage fee: 20-year Storage Prepayment Plan $1975 (Save $525) 25-year Storage Prepayment Plan $2300 (Save $825) PLEASE NOTE: Pricing is for U.S., single births only. Same-day express delivery of kit is subject to additional fees. A $150 fee will be charged if service is discontinued prior to delivery. Pricing subject to change. Pricing effective February 1, 2009 PP-P-V14 T O L L F R E E : / W W W. V I A C O R D. C O M

23 educational programs DO YOU KNOW SOMEONE ELSE WHO IS EXPECTING? At ViaCord, we believe every expectant family deserves to know about the life-saving potential of cord blood which is why we created our Referral Rewards Program: The ViaCord Referral Rewards Program Simply provide us with the names of your expectant friends and we ll send them an in-depth information packet so they can make an informed decision about preserving their baby s cord blood stem cells for their family. As a special thanks, for every friend who banks with ViaCord, we ll send you a $50 Gift Card to use anywhere Mastercard is accepted. To learn more about ViaCord s Referral Rewards Program, call toll-free: or visit *Excludes residents of Texas and Rhode Island. T O L L F R E E : / W W W. V I A C O R D. C O M PP-EP-V5