PROGRAM BOOK MARCH 4-10, Henry B. González Convention Center San Antonio,Texas

Transcription

1 PROGRAM BOOK MARCH 4-10, 2017 Henry B. González Convention Center San Antonio,Texas

2 Hold the World s Largest Pathology Meeting in the Palm of Your Hand 2017 Diagnostic Pathology Update JULY Halifax, Nova Scotia, Canada Download all the USCAP meeting information at Learn more at

3 SCHEDULE & GENERAL INFO #IAMUSCAP #USCAP2017

4 DON T THROW AWAYMEETING YOUR SHOT! ANNUAL 2017 BE IN THE ROOM WHERE IT HAPPENS. - LIN-MANUEL MIRANDA, HAMILTON (THE MUSICAL) The Nathan Kaufman Timely Topics Lecture The Maude Abbott Legacy and USCAP Honors Dr. Daniel J. Brat March 6, 4:30 P.M. Dr. Peter A. Humphrey March 7, 4:15 P.M. Stars at Night Ballroom Henry B. Gonzalez Convention Center Stars at Night Ballroom Henry B. Gonzalez Convention Center Imaginative visuals, cool messaging, electric buzz, information on the move. Pathology at the speed of thought.

5 FROM THE PRESIDENT AND EVP: MOVING INFORMATION IN THE DIGITAL AGE For the past four years, Dr. Laura W. Lamps has led the Education Committee to adopt a more progressive attitude regarding changes in presentation methodology, including the incorporation of interactive elements such as audience response systems, utilization of virtual slides, interactive microscopy modalities and a pilot approach to converting the traditional classroom to an interactive conversational venue. As Dr. Lamps transitions from her position as Chair of the Education Committee, she is recognized for excellence as the recipient of the 2017 President s Award. N. Volkan Adsay, M.D. President David B. Kaminsky, M.D., FIAC Executive Vice President Pathologists are confronted with information overload on a daily basis. Laboratories generate more than 70% of the medical record with increasingly greater impact on the delivery of healthcare. Pathology requires constant updates in new developments relevant to translational research, improved diagnostic criteria, novel methodologies and practice changers in order to fulfill its increasing role in disease management and prognostication. USCAP is a force in information generation and delivery in the world of diagnostics, and is moving pathology education to the next dimension. The 2017 Annual Meeting showcases how USCAP delivers crucial information, curated by experts, packaged in modular units, distributed digitally, available on demand, and accessible also on mobile devices. Social media is now an integral part of the information transfer. The USCAP Social Media Committee celebrated achieving 29 million tweet impressions during the 2016 Annual Meeting and routinely moves information on Facebook, Twitter, Instagram and YouTube. A novel approach was the broadcast from the USCAP Interactive Center of a segment of Dr. Jason Hornick s interactive microscopy course on soft tissue tumors on FaceBook Live on December 11, The educational programs of this meeting will now also become a part of the new modern library of digital educational assets that are professionally re-mastered and/ or developed at the studio of the USCAP Linder Learning Center, providing long-term (and much wider) access to highly respected information presented at USCAP meetings. While USCAP is proud of the way it delivers critical information, it s important to remember that we are also the consummate platform for cutting edge research in diagnostic pathology. This Annual Meeting attracted the submission of 2,700 abstracts encompassing all subspecialty areas of translational research in anatomic and molecular pathology. As in the past, the research presented and discussed at this meeting with the participation of thousands from our community will ultimately move from platforms and poster boards, leading the way to progress, new diagnostic criteria and creation of the basis of precision medicine. In this Meeting, and throughout the year at the USCAP Learning Center in Palm Springs, CA, you will also have the opportunity to benefit from the USCAP interactive microscopy sessions, 36 concise courses organized for you under the leadership of Dr. Steven Billings. Our and membership have determined that offering our educational programs also to pathologists practicing in under-resourced countries is an essential part of our mission. The engagement of Paul Lewin as Director of International Development has been an extraordinary impetus to innovating education, fostering the next generation of pathologists and promoting global health. He has facilitated, in collaboration with the Foundation Committee, the opportunity for 20 pathologists from underserved countries and 15 pathologists-in-training to attend this meeting; promoted growth of funds that support the USCAP Interactive Learning Center; and revolutionized the way courses and digital products from the Interactive Learning Center are managed for exposure and sales. Global health through philanthropy is a strategic initiative of the Academy, and we are proud of the progress we continue to make in its support. The recently improved USCAP website, is your resource for all things about the Academy. Its functional, aesthetic and personalized format is now customized to your needs and convenience. Be sure to use the APP for navigating this meeting. Harness your energies to explore all facets of this energizing and stimulating educational event. Don t miss the Maude Abbott Lecture and USCAP Honors special program at 4:15 P.M. on Tuesday, March 7, in the Stars at Night ballroom, or the Generation U celebration which is for and about you. And what you can say about yourself at the end of the week is: #IAMUSCAP. I AM A BETTER PATHOLOGIST.

6 N. VOLKAN ADSAY, M.D. PRESIDENT OF THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGISTS Dr. Volkan Adsay is Professor of Pathology, Vice Chair, and Director of Anatomic Pathology at Emory University. He completed his Anatomic Pathology and Clinical Pathology residency in New York and a two-year fellowship in Oncologic Pathology at the Memorial Sloan-Kettering Cancer Center. After 11 years as faculty at Wayne State University and Karmanos Cancer Center, he joined Emory University. Dr. Adsay is an internationally-recognized pathologist in the field of gastrointestinal and pancreatobiliary cancers. He has published over 240 peer-reviewed articles, authored several chapters in the most prestigious textbooks of Diagnostic Pathology (Sternberg s Diagnostic Surgical Pathology; Odze and Goldblum s Surgical Pathology of GI tract Liver, Biliary tract and Pancreas) Gastrointestinal Tract Surgery (Blumgart s Surgery of the Liver, Biliary Tract and Pancreas) and Oncology (Kelsen s Gastrointestinal tract Oncology), mostly focusing on cancers of pancreas, gallbladder and ampulla. He was a member of the Pancreas Review Group of National Cancer Institute, and co-author in multiple chapters in the World Health Organization s classification of tumors series. Among his contributions, he was instrumental in the pathologic characterization of various tumor types of the pancreas and biliary tract, and was also member of an international group that put forth the definition and criteria for the early cancerous lesions of these organs and prognostication of the tumors of these sites. He serves as President of the United States and Canadian Academy of Pathology (USCAP) and the Pancreatobiliary Pathology Society and as committee member in several national and international academic medical societies. He has given over 100 lectures at national and international platforms. He sits on the editorial board of 8 medical journals including American Journal of Surgical Pathology, Virchow s Archives, Modern Pathology, and Archives of Pathology and Laboratory Medicine. He is also the recipient of multiple teaching awards from medical students and residents as well as one of the recipients of the AACR Team Science Award in 2013 as a member of the Hopkins Team.

7 DAVID B. KAMINSKY, M.D., FIAC EXECUTIVE VICE PRESIDENT OF THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGISTS Dr. David B. Kaminsky assumed responsibilities of the Executive Vice President of the United States and Canadian Academy of Pathology on July 1, Prior to his affiliation with USCAP, he was a community-based pathologist in Palm Springs, California, with an academic perspective focused on education and patientcentered care. He served as Chairman of the Department of Pathology at Eisenhower Medical Center for 28 years and then established a private practice laboratory dedicated to surgical pathology and ultrasound-guided fine needle aspiration biopsy. During his tenure at the Eisenhower Medical Center, he served on the of Directors of the Annenberg Center for Health Sciences where he conceived and launched the teleconference series for the American Society of Cytopathology (ASC), and subsequently, Africa Calls, a distance learning endeavor that brings continuing medical education to 22 sites in Africa, initially funded by the Annenberg Center and now by the American Society for Clinical Pathology. As a pioneer in fine needle aspiration biopsy, he published Aspiration Biopsy for the Community Hospital in 1981 and collaborated with Dr. William J. Frable in numerous lectures and workshops to promote acceptance of aspiration biopsy as a costconservative, minimally invasive diagnostic technique. Dr. Kaminsky served as President of the American Society of Cytopathology and received the Papanicolaou Award and the President s Award. He was the inaugural President of the ASC Foundation. He is Past-President and a current active member of the California Society of Pathologists. He has lectured throughout the world on fine needle aspiration biopsy, and is the 2015 recipient of the Yolanda Oertel Interventional Cytopathologist of the Year Award of the Papanicolaou Society of Cytology and the 2016 recipient of the Maurice Goldblatt Cytology Award of the International Academy of Cytology which recognizes his lifelong love of and dedication to clinical cytology; his efforts in establishing fine needle aspiration cytology in clinical practice; his special relationship to underserved areas of the world, and his achievements in bringing knowledge and expertise to these areas; his loyal support of Acta Cytologica and the International Academy of Cytology for many years. His varied interests outside medicine include documentary film making (Academy Award Nomination for the film, short documentary category; Emmy Nomination for Executive Producer, feature documentary; Special Jury Prize for short documentary, Palm Springs International Festival of Short Films), organization of film festivals, Italian cinema, and cinematography (Palm Springs International Film Festival, Bangkok International Film Festival, American Film Institute, Palm Springs Art Museum). He was awarded bronze and silver Tellys for two programs about USCAP that were broadcast on The Discovery Channel. He was awarded the distinguished Cavaliere della Repubblica medal by the Italian government for his work in medicine and the arts, particularly Italian cinema, and a Congressional Award for Medicine by the American government. He championed the development of the Powers-Sanchez Interactive Center and the Linder Learning Center in Palm Springs, California as USCAP s resource for moving information in the digital age and personalized education/mentoring. Personal goals include collaborative education, organizational excellence and the strengthening of pathology as a world leader in contemporary medicine by dedicated commitment to USCAP. His vision includes the promotion of connectivity within the Academy, pathologist-in-training and member engagement, an invigorated Ambassador program, promotion of empathy, and the integration of arts in health care as a healing modality.

8 TRAVIS NEWMAN Managing Director Educational Program Coordinator Stand-alone Meetings

9 USCAP WOULD LIKE TO THANK THESE GENEROUS SPONSORS FOR THEIR SUPPORT OF THE NON-CME EVENTS AT THE 2017 ANNUAL MEETING.

10 THE LATEST INFORMATION ABOUT PD-L1 BIOMARKER TESTING ARE YOU UP TO DATE? VISIT BOOTH 208 TO LEARN MORE The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content, or faculty for this 2017 Annual Meeting. PD-L1 = programmed death ligand 1. Copyright 2017 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved. ONCO /16

11 Discover how pathology can enable precision medicine Personalized medicine is more than just a test. It is about building a comprehensive picture of the patient. Philips digital pathology and genomics solutions help pathologists to use multiple data sources (multi-omic, imaging, clinical), streamline workflow, share and collaborate. This can ultimately help you to get deeper insights into a patient s condition than ever before. Attend our seminar and luncheon Hear from clinical experts about the impact digital and computational pathology is having today. Monday March 6th - Time: hrs. Location: Bowie Room, San Antonio Grand Hyatt Hotel Visit us at Philips booth #202 This Exhibitor Seminar is not a part of the official USCAP Educational Program at the 2017 Annual Meeting, and is not sponsored by the USCAP. The USCAP does not officially endorse any company or its products and does not award CME credits for attendance at Exhibitor Seminars.

12 Bristol-Myers Squibb looks forward to seeing you at USCAP 2017 J O I N U S Please come visit Bristol-Myers Squibb at Booth 126 for an interactive experience on PD-L1 and the evolving science of immune-biomarkers. The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting. Bristol-Myers Squibb Company. All rights reserved. ONCUS /16

13 The Rising Star in Immunotherapy Markers PD-L1 + TTF-1 PD-L1 + p40 + CD8 CK5/14 + p63 + CK7/18 Lung adenocarcinoma } Immune checkpoint marker in tumor immunotherapy 1,2 } PD-L1 stains tumor membrane (brown) 3 Lung squamous carcinoma } PD-L1 stains tumor membranes (brown) 1,2 } p40 stains tumor cell nuclei (blue) 3 } TTF-1 stains tumor nuclei (blue) 1,2 } CD8 + T cells are stained red & scattered within tumor cells 3 Cat. : PD-L1 ACI 3171, API 3171; TTF-1 ACI 3126, API 3126; p40 ACI 3066, API 3066; CD8 ACI 3160, API 3160 Visit Us For a Full Range of Immunotherapy Markers... Order Online 24/7! Brahmer J, et al. NEJM 2015;373: Melosky, B, et al. J Clin Oncol 2016;14: Kakavand, H, et al. Pathology 2016;48: The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting.

14 Your single-source laboratory solution. More than 490,000 tests performed on 225,000+ patients annually access answers actions Integrated with more than 700 electronic medical records (EMR) and practice management systems Menu of more than 450 genetic, pathology, IHC, and FISH tests, including 15 oncologyspecific pharmacogenetic tests Staff of more than 75 pathologists, PhDs, and genetic counselors dedicated to oncology and familial cancer testing Official Silver Sponsor of USCAP 17 Booth #510 The sponsor of this ad verifi es that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting Laboratory Corporation of America Holdings. All rights reserved. onc-933-v Visit booth #513 Turnkey Digital Pathology Solution from OptraSCAN! Starting at $1950 USD* On-Demand Monthly Subscription 15 or 120 Slide WSI Scanners Brightfield, Fluorescent & Frozen Sections Models Small Footprint Cloud Storage, LIMS, Sharing and Telepathology Consults Pay-per-use Image Analysis Assays: H&E, IHC & FISH [email protected] For research-use only The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting. *Monthly subscription available for US & Canada only

15 Precision Diagnosis is the Foundation of Precision Medicine. Inspirata offers a comprehensive and integrated Cancer Diagnostics Workflow Solution available for clinical and translational research. The solution automates anatomic and molecular pathology workflows, providing whole slide imaging and image analysis, companion diagnostics, consultations, tumor board support and the construction of a big data repository. Visit us at USCAP in Booth #310 to learn more. Integrated Anatomic & Molecular Pathology Workflow & Cockpit Consultation Portal Whole Slide Imaging Decision Support & Directed Review Image Analysis Predictive & Prognostic Assays Multi-Disciplinary Tumor Big Data Analytics with NLP Engine The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting.

16 ACHIEVE MORE WITH EUS Acquire confidence in your diagnosis SharkCore Fine Needle Biopsy Needle Medtronic.com/gi Visit us in Booth 705 The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting. US150849a(1) 2017 Medtronic. All rights reserved. Medtronic, Medtronic logo and Further, Together are trademarks of Medtronic.

17 ctdna TESTING NOW FDA APPROVED FOR TAGRISSO (osimertinib) IN PATIENTS WITH METASTATIC EGFR NON-SMALL CELL LUNG CANCER (NSCLC) WHO HAVE PROGRESSED ON OR AFTER EGFR TKI THERAPY TAGRISSO HAS THE ONLY FDA-APPROVED, CLINICALLY VALIDATED COMPANION DIAGNOSTIC TEST FOR THE EGFR T790M MUTATION THAT USES EITHER TISSUE OR PLASMA 1 Incorporating both tissue and plasma testing into your practice may identify more patients with the EGFR T790M mutation 2 Testing for the presence of the EGFR T790M mutation in plasma specimens is recommended only in patients where tumor tissue is not available 3 If this mutation is not detected in a plasma specimen, re-evaluate the feasibility of biopsy for tumor tissue testing 3 The cobas EGFR Mutation Test v2 was clinically validated based on its results in the TAGRISSO clinical trials 1 Confirm the presence of the EGFR T790M mutation prior to prescribing TAGRISSO 3 TAGRISSO DEMONSTRATED EFFICACY IN TWO CLINICAL TRIALS Effective in two separate global, Phase II, single-arm, open-label clinical trials in patients with metastatic EGFR T790M mutation-positive NSCLC who had progressed on or after EGFR TKI therapy 3 A 59% objective response rate (95% CI: 54 64) observed in patients who progressed with previous EGFR TKI therapy 3 Interstitial Lung Disease (ILD) occurred in 3.3% and was fatal in 0.5% of TAGRISSO patients 3 Visit TAGRISSOhcp.com for more information References: 1. cobas EGFR Mutation Test v2 [package insert]. Indianapolis, IN: Roche Molecular Systems, Inc Diaz LA Jr, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 2014;32: TAGRISSO [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2016.

18 WHEN PATIENTS PROGRESS, IT S TIME TO TEST IMPORTANT SAFETY INFORMATION There are no contraindications for TAGRISSO Interstitial Lung Disease (ILD)/Pneumonitis occurred in 3.3% and was fatal in 0.5% of 813 TAGRISSO patients. Withhold TAGRISSO and promptly investigate for ILD in any patient presenting with worsening of respiratory symptoms indicative of ILD (e.g., dyspnea, cough and fever). Permanently discontinue TAGRISSO if ILD is confirmed QTc interval prolongation occurred in TAGRISSO patients. Of the 411 patients in two Phase II studies, 0.2% were found to have a QTc greater than 500 msec, and 2.7% had an increase from baseline QTc greater than 60 msec. Conduct periodic monitoring with ECGs and electrolytes in patients with congenital long QTc syndrome, congestive heart failure, electrolyte abnormalities, or those who are taking medications known to prolong the QTc interval. Permanently discontinue TAGRISSO in patients who develop QTc interval prolongation with signs/symptoms of life threatening arrhythmia Cardiomyopathy occurred in 1.4% and was fatal in 0.2% of 813 TAGRISSO patients. Left Ventricular Ejection Fraction (LVEF) decline >10% and a drop to <50% occurred in 2.4% of (9/375) TAGRISSO patients. Assess LVEF before initiation and then at 3 month intervals of TAGRISSO treatment. Withhold TAGRISSO if ejection fraction decreases by 10% from pretreatment values and is less than 50%. For symptomatic congestive heart failure or persistent asymptomatic LV dysfunction that does not resolve within 4 weeks, permanently discontinue TAGRISSO Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during TAGRISSO treatment and for 6 weeks after the final dose. Advise males with female partners of reproductive potential to use effective contraception for 4 months after the final dose The most common adverse reactions (>20%) observed in TAGRISSO patients were diarrhea (42%), rash (41%), dry skin (31%) and nail toxicity (25%) INDICATION TAGRISSO is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR tyrosine kinase inhibitor therapy. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. Please see Brief Summary of complete Prescribing Information on adjacent page. TAGRISSO is a registered trademark of the AstraZeneca group of companies. COBAS is a registered trademark of Roche 2016 AstraZeneca. All rights reserved /16

19 TAGRISSO TM (osimertinib) tablets, for oral use Brief Summary of Prescribing Information. For complete prescribing information consult official package insert. INDICATIONS AND USAGE TAGRISSO is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR tyrosine kinase inhibitor (TKI) therapy. This indication is approved under accelerated approval based on tumor response rate and duration of response [see Clinical Studies (14) in full Prescribing Information]. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. DOSAGE AND ADMINISTRATION Patient Selection Confirm the presence of a T790M EGFR mutation in tumor or, in the absence of tumor, plasma specimens prior to initiation of treatment with TAGRISSO [see Indications and Usage (1) and Clinical Studies (14) in full Prescribing Information]. Testing for the presence of the mutation in plasma specimens is recommended only in patients for whom a tumor biopsy cannot be obtained. If this mutation is not detected in a plasma specimen, re-evaluate the feasibility of biopsy for tumor tissue testing. Information on FDA-approved tests for the detection of T790M mutations is available at Recommended Dosage Regimen The recommended dose of TAGRISSO is 80 mg tablet once a day until disease progression or unacceptable toxicity. TAGRISSO can be taken with or without food. If a dose of TAGRISSO is missed, do not make up the missed dose and take the next dose as scheduled. Administration to Patients Who Have Difficulty Swallowing Solids Disperse tablet in 60 ml (2 ounces) of non-carbonated water only. Stir until tablet is dispersed into small pieces (the tablet will not completely dissolve) and swallow immediately. Do not crush, heat, or ultrasonicate during preparation. Rinse the container with 120 ml to 240 ml (4 to 8 ounces) of water and immediately drink. If administration via naso-gastric tube is required, disperse the tablet as above in 15 ml of non-carbonated water, and then use an additional 15 ml of water to transfer any residues to the syringe. The resulting 30 ml liquid should be administered as per the nasogastric tube instructions with appropriate water flushes (approximately 30 ml). Dosage Modification Adverse Reactions Table 1 Recommended Dose Modifications for TAGRISSO Target Organ Adverse Reaction a Dose Modification Interstitial lung disease Permanently discontinue TAGRISSO. Pulmonary (ILD)/Pneumonitis a b c Cardiac Other QTc interval greater than 500 msec on at least 2 separate ECGs b QTc interval prolongation with signs/symptoms of life-threatening arrhythmia Asymptomatic, absolute decrease in LVEF c of 10% from baseline and below 50% Symptomatic congestive heart failure Grade 3 or higher adverse reaction If improvement to Grade 0-2 within 3 weeks If no improvement within 3 weeks Withhold TAGRISSO until QTc interval is less than 481 msec or recovery to baseline if baseline QTc is greater than or equal to 481 msec, then resume at 40 mg dose. Permanently discontinue TAGRISSO. Withhold TAGRISSO for up to 4 weeks. If improved to baseline LVEF, resume. If not improved to baseline, permanently discontinue. Permanently discontinue TAGRISSO. Withhold TAGRISSO for up to 3 weeks. Resume at 80 mg or 40 mg daily. Permanently discontinue TAGRISSO. Adverse reactions graded by the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 (NCI CTCAE v4.0). ECGs = Electrocardiograms LVEF = Left Ventricular Ejection Fraction QTc = QT interval corrected for heart rate Drug Interactions Strong CYP3A4 Inducers If concurrent use is unavoidable, increase TAGRISSO dosage to 160 mg daily when coadministering with a strong CYP3A inducer. Resume TAGRISSO at 80 mg 3 weeks after discontinuation of the strong CYP3A4 inducer [see Drug Interactions (7), and Clinical Pharmacology (12.3) in full Prescribing Information]. CONTRAINDICATIONS None. WARNINGS AND PRECAUTIONS Interstitial Lung Disease/Pneumonitis Across clinical trials, interstitial lung disease (ILD)/pneumonitis occurred in 3.3% (n=27) of TAGRISSO treated patients (n=813); 0.5% (n=4) were fatal. Withhold TAGRISSO and promptly investigate for ILD in any patient who presents with worsening of respiratory symptoms which may be indicative of ILD (e.g., dyspnea, cough and fever). Permanently discontinue TAGRISSO if ILD is confirmed [see Dosage and Administration (2.4) and Adverse Reactions (6) in full Prescribing Information]. QTc Interval Prolongation The heart rate-corrected QT (QTc) interval prolongation occurs in patients treated with TAGRISSO. Of the 411 patients in Study 1 and Study 2, one patient (0.2%) was found to have a QTc greater than 500 msec, and 11 patients (2.7%) had an increase from baseline QTc greater than 60 msec [see Clinical Pharmacology (12.2) in full Prescribing Information]. In Study 1 and 2, patients with baseline QTc of 470 msec or greater were excluded. Conduct periodic monitoring with ECGs and electrolytes in patients with congenital long QTc syndrome, congestive heart failure, electrolyte abnormalities, or those who are taking medications known to prolong the QTc interval. Permanently discontinue TAGRISSO in patients who develop QTc interval prolongation with signs/symptoms of life-threatening arrhythmia [see Dosage and Administration (2.4) in full Prescribing Information]. Cardiomyopathy Across clinical trials, cardiomyopathy (defined as cardiac failure, pulmonary edema, ejection fraction decreased or stress cardiomyopathy) occurred in 1.4% (n=11) of TAGRISSO treated patients (n=813); 0.2% (n=2) were fatal. In Study 1 and Study 2, Left Ventricular Ejection Fraction (LVEF) decline >10% and a drop to <50% occurred in 2.4% (9/375) of patients who had baseline and at least one follow-up LVEF assessment. Assess LVEF by echocardiogram or multigated acquisition (MUGA) scan before initiation of TAGRISSO and then at 3 month intervals while on treatment. Withhold treatment with TAGRISSO if ejection fraction decreases by 10% from pretreatment values and is less than 50%. For symptomatic congestive heart failure or persistent, asymptomatic LV dysfunction that does not resolve within 4 weeks, permanently discontinue TAGRISSO [see Dosage and Administration (2.4) in full Prescribing Information]. Embryo-Fetal Toxicity Based on data from animal studies and its mechanism of action, TAGRISSO can cause fetal harm when administered to a pregnant woman. In animal reproduction studies, osimertinib caused post-implantation fetal loss when administered during early development at a dose exposure 1.5 times the exposure at the recommended human dose. When males were treated prior to mating with untreated females, there was an increase in preimplantation embryonic loss at plasma exposures of approximately 0.5-times those observed in patients at the 80 mg dose level. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with TAGRISSO and for 6 weeks after the final dose. Advise males with female partners of reproductive potential to use effective contraception for 4 months after the final dose [see Use in Specific Populations (8.1), (8.3) and Clinical Pharmacology (12.3) in full Prescribing Information]. ADVERSE REACTIONS The following adverse reactions are discussed in greater detail in other sections of the labeling: Interstitial Lung Disease/Pneumonitis [see Warnings and Precautions (5.1) in full Prescribing Information] QTc Interval Prolongation [see Warnings and Precautions (5.2) in full Prescribing Information] Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The data described below reflect exposure to TAGRISSO (80 mg daily) in 411 patients with EGFR T790M mutation-positive non-small cell lung cancer who received prior EGFR TKI therapy, in two single-arm studies, Study 1 and Study 2. Patients with a past medical history of ILD or radiation pneumonitis that required steroid treatment, serious arrhythmia or baseline QTc interval greater than 470 ms were excluded from Study 1 and Study 2. Baseline patient and disease characteristics were: median age 63 years, 13% of patients were 75 years old, female (68%), White (36%), Asian (60%), metastatic (96%), sites of brain metastases (39%), World Health Organization (WHO) performance status of 0 (37%) or 1 (63%), 1 prior line of therapy [EGFR-TKI treatment only, second line, chemotherapynaïve (31%)], 2 or more prior lines of therapy (69%). Of the 411 patients, 333 patients were exposed to TAGRISSO for at least 6 months; 97 patients were exposed for at least 9 months; however, no patient was exposed to TAGRISSO for 12 months. In Studies 1 and 2, the most common (>20%) adverse reactions (all grades) observed in TAGRISSO-treated patients were diarrhea (42%), rash (41%), dry skin (31%), and nail toxicity (25%). Dose reductions occurred in 4.4% of patients treated with TAGRISSO. The most frequent adverse reactions that led to dose reductions or interruptions were: electrocardiogram QTc prolonged (2.2%) and neutropenia (1.9%). Serious adverse reactions reported in 2% or more patients were pneumonia and pulmonary embolus. There were 4 patients (1%) treated with TAGRISSO who developed fatal adverse reactions of ILD/pneumonitis. Other fatal adverse reactions occurring in more than 1 patient included pneumonia (4 patients) and CVA/cerebral hemorrhage (2 patients). Discontinuation of therapy due to adverse reactions occurred in 5.6% of patients treated with TAGRISSO. The most frequent adverse reactions that led to discontinuation were ILD/pneumonitis and cerebrovascular accidents/infarctions. Tables 2 and 3 summarize the common adverse reactions and laboratory abnormalities observed in TAGRISSO-treated patients.

20 TAGRISSO TM (osimertinib) tablets, for oral use 2 Table 2 Adverse Reactions (>10% for all NCI CTCAE* Grades or >2% for Grades 3-4) in Study 1 and Study 2 TAGRISSO N=411 Adverse Reaction All Grades Grade 3-4 f % % Gastrointestinal disorders Diarrhea Nausea Decreased appetite Constipation Stomatitis 12 0 Skin disorders Rash a Dry skin b 31 0 Nail toxicity c 25 0 Pruritus 14 0 Eye Disorders d Respiratory Cough General Fatigue Musculoskeletal Back pain Central Nervous System Headache Infections Pneumonia Vascular events Venous thromboembolism e * NCI CTCAE v4.0. a Includes cases reported within the clustered terms for rash adverse events: Rash, rash generalized, rash erythematous, rash macular, rash maculo-papular, rash papular, rash pustular, erythema, folliculitis, acne, dermatitis and acneform dermatitis. b c Includes dry skin, eczema, skin fissures, xerosis. Includes nail disorders, nail bed disorders, nail bed inflammation, nail bed tenderness, nail discoloration, nail disorder, nail dystrophy, nail infection, nail ridging, onychoclasis, onycholysis, onychomadesis, paronychia. d Includes dry eye, vision blurred, keratitis, cataract, eye irritation, blepharitis, eye pain, lacrimation increased, vitreous floaters. Other ocular toxicities occurred in <1% of patients. e Includes deep vein thrombosis, jugular venous thrombosis, and pulmonary embolism. f No grade 4 events have been reported. Additional clinically significant adverse reactions occurring in 2% or more of patients treated with TAGRISSO included cerebrovascular accident (2.7%). Table 3 Laboratory Abnormalities (>20% for all NCI CTCAE Grades) in Study 1 and Study 2 Laboratory Abnormality Change from Baseline All Grades (%) TAGRISSO N=411 Change from Baseline to Grade 3 or Grade 4 (%) a Clinical Chemistry Hyponatremia Hypermagnesemia Hematologic Lymphopenia Thrombocytopenia a Anemia Neutropenia a The only grade 4 laboratory abnormality was 1 patient with grade 4 thrombocytopenia. DRUG INTERACTIONS Effect of Other Drugs on Osimertinib Strong CYP3A Inducers Coadministering TAGRISSO with a strong CYP3A4 inducer decreased the exposure of osimertinib compared to administering TAGRISSO alone [see Clinical Pharmacology (12.3) in full Prescribing Information]. Decreased osimertinib exposure may lead to reduced efficacy. Avoid coadministering TAGRISSO with strong CYP3A inducers (e.g., phenytoin, rifampin, carbamazepine, St. John s Wort) [note: effect of St. John s Wort varies widely and is preparation-dependent]. Increase the TAGRISSO dosage when coadministering with a strong CYP3A4 inducer if concurrent use is unavoidable [see Dosage and Administration (2.4) in full Prescribing Information]. No dose adjustments are required when TAGRISSO is used with moderate and/or weak CYP3A inducers. Effect of Osimertinib on Other Drugs Coadministering TAGRISSO with a BCRP substrate increased the exposure of the BCRP substrate compared to administering the BCRP substrate alone [see Clinical Pharmacology (12.3) in full Prescribing Information]. Increased BCRP substrate exposure may increase the risk of exposure-related toxicity. Monitor for adverse reactions of the BCRP substrate (e.g., rosuvastatin, sulfasalazine, topotecan), unless otherwise instructed in its approved labeling, when coadministered with TAGRISSO. USE IN SPECIFIC POPULATIONS Pregnancy Risk Summary Based on data from animal studies and its mechanism of action, TAGRISSO can cause fetal harm when administered to a pregnant woman. There are no available data on TAGRISSO use in pregnant women. Administration of osimertinib to pregnant rats was associated with embryolethality and reduced fetal growth at plasma exposures 1.5 times the exposure at the recommended human dose [see Data]. Advise pregnant women of the potential risk to a fetus. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically-recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Data Animal Data When administered to pregnant rats prior to embryonic implantation through the end of organogenesis (gestation days 2-20) at a dose of 20 mg/kg/day, which produced plasma exposures of approximately 1.5 times the clinical exposure, osimertinib caused postimplantation loss and early embryonic death. When administered to pregnant rats from implantation through the closure of the hard palate (gestation days 6 to 16) at doses of 1 mg/kg/day and above (0.1-times the AUC observed in patients at the recommended dose of 80 mg), an equivocal increase in the rate of fetal malformations and variations was observed in treated litters relative to those of concurrent controls. When administered to pregnant dams at doses of 30 mg/kg/day during organogenesis through lactation Day 6, osimertinib caused an increase in total litter loss and postnatal death. At a dose of 20 mg/kg/day, osimertinib administration during the same period resulted in increased postnatal death as well as a slight reduction in mean pup weight at birth that increased in magnitude between lactation days 4 and 6. Lactation Risk Summary There are no data on the presence of osimertinib in human milk, the effects of osimertinib on the breastfed infant or on milk production. Administration to rats during gestation and early lactation was associated with adverse effects, including reduced growth rates and neonatal death [see Use in Specific Populations (8.1) in full Prescribing Information]. Because of the potential for serious adverse reactions in breastfed infants from osimertinib, advise a lactating woman not to breastfeed during treatment with TAGRISSO and for 2 weeks after the final dose. Females and Males of Reproductive Potential Contraception Females Advise females of reproductive potential to use effective contraception during treatment with TAGRISSO and for 6 weeks after the final dose [see Use in Specific Populations (8.1) in full Prescribing Information]. Males Advise male patients with female partners of reproductive potential to use effective contraception during and for 4 months following the final dose of TAGRISSO [see Nonclinical Toxicology (13.1) in full Prescribing Information]. Infertility Based on animal studies, TAGRISSO may impair fertility in females and males of reproductive potential. The effects on female fertility showed a trend toward reversibility. It is not known whether the effects on male fertility are reversible [see Nonclinical Toxicology (13.1) in full Prescribing Information]. Pediatric Use The safety and effectiveness of TAGRISSO in pediatric patients have not been established. Geriatric Use One hundred eighty-seven (45%) of the 411 patients in clinical trials of TAGRISSO were 65 years of age and older, and 54 patients (13%) were 75 years of age and older. No overall differences in effectiveness were observed based on age. Exploratory analysis suggests a higher incidence of Grade 3 and 4 adverse reactions (32% versus 25%) and more frequent dose modifications for adverse reactions (23% versus 17%) in patients 65 years or older as compared to those younger than 65 years. Renal Impairment No dose adjustment is recommended in patients with mild [creatinine clearance (CLcr) ml/min, as estimated by the Cockcroft Gault method (C-G)] or moderate (CLcr ml/min, as estimated by C-G) renal impairment. There is no recommended dose of TAGRISSO for patients with severe renal impairment (CLcr <30 ml/min) or end-stage renal disease [see Clinical Pharmacology (12.3) in full Prescribing Information]. Hepatic Impairment No dose adjustment is recommended in patients with mild hepatic impairment [total bilirubin less than or equal to upper limit of normal (ULN) and AST greater than ULN or total bilirubin between 1.0 to 1.5 times ULN and any AST]. There is no recommended dose for TAGRISSO for patients with moderate or severe hepatic impairment [see Clinical Pharmacology (12.3) in full Prescribing Information]. Distributed by: AstraZeneca Pharmaceuticals LP, Wilmington, DE TAGRISSO is a trademark of the AstraZeneca group of companies AstraZeneca 2015 Iss. 09/ /16

21 Protect Patients and Improve Productivity with CEREBRO Sample Tracking and Workflow Solutions Visit us at USCAP 2017 Booth Automate Tracking Verify specimen identity at every step 2. Enhance Productivity Gain efficiency and drive continuous improvement 3. Maintain Control Use your patient ID and preferred instruments CEREBRO Workflow management for increased efficiency and patient safety The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content or faculty for this 2017 Annual Meeting. LeicaBiosystems.com/CEREBRO Copyright 2017 Leica Biosystems Imaging, Inc. All Rights Reserved. LEICA and the Leica logo are registered trademarks of Leica Microsystems IR GmbH. CEREBRO is a trademark of the Leica Biosystems group of companies in the USA and optionally in other countries Rev A. 01/2017

22 Belonging. The word includes longing..to discover each other.to connect, share our inner selves.to absorb new information, create ideas.to see in a new way.to think out loud and talk about it like you were singing.to embrace our differences.to imagine a healthy world because of you Membership benefits include: 25% discount on all meetings and educational seminars including the USCAP Annual Meeting Enhanced career paths Networking opportunities with world-class experts Personalized life-long learning Additional benefits to make you a better pathologist USCAP. Where you belong. For good. Renew or apply for membership today at

23 MIND YOUR BUSINESS USCAP s BUSINESS changes how you think, what you know, and the world. See for yourself at USCAP's official Annual Business Meeting. Saturday, March 4 3:30 P.M. Henry B. González Convention Center Cantilever MARCH 4-10, 2017 SAN ANTONIO, TEXAS

24 GENERATION U U are the NOW generation, hip, vibrant, electric, inventive, passionate, thirsty for the future. What s next is what s up at your party. Discover its mystery and passion. 6-7:30. Tuesday, Grand Hyatt Texas Ballroom

25 USCAP PHOTO BOOTH BE THE STAR OF THE SHOW Welcome home to your Academy! Grab a colleague, mentor, or friend and stop by the complimentary USCAP Photo Booth located outside the Exhibit Hall. Capture the fun and energy of the 2017 USCAP Annual Meeting with the Photo Booth, take home photos and share your experience on Facebook, Twitter or Instagram. Throughout the meeting, tag your photos with #IAMUSCAP and #USCAP2017 and stop by the photo booth to get a free printout! Located Outside the Exhibit Hall WIN AN APPLE WATCH! Take selfies at all of the marked locations throughout the meeting, hashtag them with #USCAPselfie17 and #IAMUSCAP, and be entered to win. ACTUAL PRIZE WATCH MAY VARY FROM SHOWN Details on the USCAP app. LOOK FOR THE SELFIE SPOTS!

26 GLOBAL. EMPATHY. UNDERSERVED. PHILANTHROPY. TECHNOLOGY. NEED. DIGITAL OUTREACH. KNOWLEDGE TRANSFER. RESPONSIBILITY. Creating a Better Pathologist for a Healthier World.

27 2017 TABLE OF CONTENTS TAB 1 - SCHEDULE & GENERAL INFORMATION Certificate of CME/SAM Credit of Participation...p. 3 Coffee Breaks/Headshot Lounge Open...p. 4 Daily Program Outline/Meeting at a Glance...p Convention Hall Floor Plans...p. 13 Marriott Rivercenter Floor Plan...p.14 Marriott Riverwalk Floor Plan...p. 15 Grand Hyatt Floor Plans...p Exhibit Hall Information and Floor Plan...p. 18 Poster Pickup and Viewing Station...p. 19 USCAP Operations...p. 19 Past Presidents and Secretary-Treasurers...p. 20 In Memoriam...p. 21 USCAP and Committee Members...p Business Meeting Agenda...p Business Meeting Minutes...p International Academy of Pathology Session...p Affiliate Events...p TAB 2 - PATHOLOGISTS-IN-TRAINING Welcome Message from Resident Advisory Chair...p. 37 Fellowship Fair...p Resident Advisory Committee...p. 40 TAB 3 - COMPANION SOCIETY MEETINGS Saturday - Companion Meetings...p Sunday - Companion Meetings...p TAB 4 - SPECIALTY CONFERENCES Sunday - Genitourinary Pathology...p. 67 Sunday - Ophthalmic Pathology...p. 67 Sunday - Pathologist-in-Training...p. 68 Sunday - Pediatric Pathology...p. 68 Monday - Bone and Soft Tissue Pathology...p. 69 Monday - Cytopathology...p. 69 Monday - Hematopathology...p. 70 Monday - Liver Pathology...p. 70 Tuesday - Cardiovascular Pathology...p. 71 Tuesday - Dermatopathology... p. 71 Tuesday - Neuropathology... p. 72 Tuesday - Surgical Pathology...p. 72 Wednesday - Breast Pathology...p. 73 Wednesday - Gastrointestinal Pathology...p. 73 Wednesday - Infectious Disease Pathology...p. 74 Wednesday - Renal Pathology... p. 74 Thursday - Gynecologic Pathology...p. 75 Thursday - Head and Neck, and Endocrine Pathology...p. 75 Thursday - Pulmonary Pathology...p. 76 TAB 5 - SPECIAL COURSES Saturday - Residents' Workshop: Genomic Medicine for Pathologists: What You Need to Know...p Monday - Facebook, Twitter, Instagram, et al: Everything a Pathologist Needs to Know to be a Social Media Pro...p Monday - Clinical Application of Next Generation Sequencing for the Management of Patients with Solid Tumors...p Monday - Tumor Immunology: Implications for TNM Staging and Therapeutics...p Tuesday - Molecular Diagnostic and Genomic Applications in Cancer: A Primer for the Pathologist...p Monday - Interactive Microscopy...p Tuesday - Interactive Microscopy...p Wednesday - Interactive Microscopy...p Thursday - Interactive Microscopy...p Monday - Hot Topics in Pathology...p. 94 Tuesday - Hot Topics in Pathology...p. 94 Wednesday - Hot Topics in Pathology...p. 94 Thursday - Hot Topics in Pathology...p. 95 Timely Topics Lecture...p. 96 Maude Abbott Lecture...p. 96 TAB 6 - LONG COURSE Prostate Pathology: Practical Issues...p TAB 7 - SHORT COURSES Wednesday...p Thursday...p Friday...p TAB 8 - SPECIAL LECTURES TAB 9 - USCAP HONORS TAB 10 - ABSTRACTS Proffered Papers Monday AM...p Monday PM...p Tuesday AM...p Tuesday PM...p Poster Sessions I - Monday AM...p II - Monday PM...p III - Tuesday AM...p IV - Tuesday PM...p V - Wednesday AM...p VI - Wednesday PM...p Abstract Review...p. 257 Abstract Disclosure Information...p TAB 11 - INDEX 1

28 NOTES 2

29 CERTIFICATE OF CME/SAM CREDIT OR PARTICIPATION ACCREDITATION STATEMENT The United States and Canadian Academy of Pathology (USCAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. AMA CREDIT DESIGNATION STATEMENT The USCAP designates this live activity for a maximum of AMA PRA Category 1 Credit(s). Physicians should only claim the credit commensurate with the extent of their participation in the activity. INTERNATIONAL PHYSICIANS The American Medical Association has determined that physicians not licensed in the US who participate in this CME activity are eligible for AMA PRA Category 1 Credit(s). HEALTH PROFESSIONALS Health Professional participants (including residents and fellows-in-training) may claim hours to receive a Certificate of Participation for an activity designated for AMA PRA Category 1 Credit(s). SELF-ASSESSMENT MODULE CREDITS The USCAP is approved by the American of Pathology to offer Self-Assessment Module (SAM) credits for the purpose of meeting the American of Pathology (ABP) requirements for Maintenance of Certification (MOC). Registrants must take and pass the post-test in order to claim SAM credit(s). The number of SAM credits has increased again this year. There will be more than 310 SAMs credits offered during this year's meeting. Since many of these offerings are presented in overlapping time slots, an individual may earn a maximum of SAMs credit hours during the Annual Meeting. SESSION TYPES FOR WHICH AMA PRA CATEGORY 1 CREDITS ARE OFFERED: SCIENTIFIC ABSTRACT PRESENTATIONS SPECIALTY CONFERENCES KAUFMAN TIMELY TOPICS LECTURE MAUDE ABBOTT LECTURE LONG COURSE SHORT COURSES MOLECULAR DIAGNOSTIC AND GENOMIC APPLICATIONS IN CANCER TUMOR IMMUNOLOGY: IMPLICATIONS FOR TNM NEXT GENERATION SEQUENCING SPECIAL COURSE INTERACTIVE MICROSCOPY HOT TOPICS IN PATHOLOGY FACEBOOK, TWITTER, INSTAGRAM, ET. AL: EVERYTHING A PATHOLOGIST NEEDS TO KNOW TO BE A SOCIAL MEDIA PRO THE INSIDER'S GUIDE TO QUALITY IMPROVEMENT 8.75 TOTAL CREDITS 2.0 CREDITS EACH 1.0 CREDIT 1.0 CREDIT 6.0 CREDITS 3.0 CREDITS EACH 7.25 CREDITS 3.0 CREDITS 3.75 CREDITS 1.5 CREDITS EACH 1.0 CREDITS EACH 3.0 CREDITS 3.0 CREDITS The Companion Society Meeting activities have been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the United States and Canadian Academy of Pathology and the Companion Societies listed below. The United States and Canadian Academy of Pathology is accredited by the ACCME to provide continuing medical education for physicians. COMPANION SOCIETY MEETINGS EXCEPT* *HISTORY OF PATHOLOGY SOCIETY AND PALEOPATHOLOGY CLUB American Association of Neuropthologists American Association of Ocular Oncologists and Pathologists American Society for Investigative Pathology Arthur Purdy Stout Society of Surgical Pathologists Association for Molecular Pathology Association for Pathology Informatics Binford-Dammin Society of Infectious Disease Pathologists Endocrine Pathology Society Hans Popper Hepatopathology Society History of Pathology Society* International Society of Bone & Soft Tissue Pathology International Society of Breast Pathology 3.0 CREDITS EACH 1.5 CREDITS EACH International Society of Gynecological Pathologists International Society of Urological Pathology North American Society of Head & Neck Pathology Paleopathology Club* Papanicolaou Society of Cytopathology Pulmonary Pathology Society Renal Pathology Society Rodger C. Haggitt Gastrointestinal Pathology Society Society for Cardiovascular Pathology Society for Hematopathology Society for Ultrastructural Pathology 3

30 SCHEDULE & GENERAL INFO REGISTRATION DESK SCHEDULE The USCAP Registration Desk will be located in the Henry B. González Convention Center, Hall 1 Registration area on the first floor. SATURDAY, MARCH 4 SUNDAY, MARCH 5 THROUGH THURSDAY, MARCH 9 FRIDAY, MARCH 10 1:00 PM 8:00 PM 7:00 AM 5:00 PM 7:00 AM 1:00 PM COFFEE BREAKS DAY DATE START TIME END TIME SUNDAY MARCH 5 10:00 AM* 10:30 AM SUNDAY MARCH 5 3:00 PM* 3:30 PM MONDAY MARCH 6 9:30 AM* 11:00 AM MONDAY MARCH 6 3:00 PM* 4:30 PM TUESDAY MARCH 7 9:30 AM* 11:00 AM TUESDAY MARCH 7 2:45 PM 4:00 PM WEDNESDAY MARCH 8 9:30 AM* 11:00 AM WEDNESDAY MARCH 8 2:30 PM* 4:00 PM THURSDAY MARCH 9 9:30 AM 10:00 AM THURSDAY MARCH 9 2:30 PM 3:00 PM FRIDAY MARCH 10 9:30 AM 10:00 AM FRIDAY MARCH 10 2:30 PM 3:00 PM * Headshots will be available in CC 224 during these coffee breaks HEADSHOT LOUNGE Stop by CC 224 any time during the coffee breaks March 5th-8th (excluding the afternoon of March 7th) to get your headshot taken by our professional photographers. This service will be complimentary for members and only $50 for non-members. 4

31 SCHEDULE & GENERAL INFO MEETING AT A GLANCE 2017 MEETING AT A GLANCE INFORMATION IN THIS SECTION WAS CURRENT AS OF MARCH 4. FOR LAST MINUTE UPDATES, YOU CAN GO ONLINE AT OR VIEW IN THE USCAP MOBILE APP USCAP365 AVAILABLE AT THE APP STORE AND GOOGLE PLAY. USCAP 2017 NEWS EMBARGO POLICY Unless otherwise noted, all abstracts presented at the USCAP Annual Meeting are embargoed until the date and time of presentation. Abstracts presented at a news conference are embargoed until the date and time of the news conference. The USCAP reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during the USCAP Annual Meeting. USCAP 2017 DISCLAIMER STATEMENT The information presented at the USCAP news conferences and within the Research Summaries Book represents the opinion of the presenters and authors and is not necessarily the view of the USCAP. The USCAP makes no representation as to the truth or warranty, accuracy, or originality of the information presented. 5

32 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION **CC= Convention Center RC= Rivercenter GH= Grand Hyatt SNB= Stars at Night Ballroom in Convention Center SATURDAY, MARCH 4, :00 AM - 5:00 PM SPECIAL COURSE Residents Workshop: Genomic Medicine for Pathologists...p CC 221 A (Ticketed) 3:30 PM - 4:00 PM USCAP BUSINESS MEETING...p CC 220 Cantilever 7:00 PM - 10:00 PM COMPANION SOCIETY MEETINGS American Association of Neuropathologists...p CC 221 A-C Association for Pathology Informatics...p.42...CC 221 D Endocrine Pathology Society...p CC Hemisfair 2 Papanicolaou Society of Cytopathology...p CC Hemisfair 3 Pulmonary Pathology Society...p CC 225 International Society of Urological Pathology...p CC Hemisfair 1 SUNDAY, MARCH 5, :00 AM - 8:00 AM YOGA WITH LAURA LAMPS: 2017 MILES FOR MENTORS: YOGA EDITION... GH Pool Terrace (Ticketed) 8:30 AM - 12:00 PM COMPANION SOCIETY MEETINGS Arthur Purdy Stout Society of Surgical Pathologists...p CC Hemisfair 2&3 Society for Cardiovascular Pathology with Binford-Dammin Society of Infectious Disease Pathologists...p CC 304 College of American Pathologists...p CC Hemisfair 1 Hans Popper Hepatopathology Society...p CC 225 Renal Pathology Society...p CC 303 AB Society for Ultrastructural Pathology...p CC 303 C 1:30 PM - 3:00 PM COMPANION SOCIETY MEETING Paleopathology Club...p CC 302 C 1:30 PM - 5:00 PM COMPANION SOCIETY MEETINGS American Association of Ocular Oncologists and Pathologists...p CC 303 AB American Society for Investigative Pathology...p CC 302 AB American Society for Clinical Pathology...p CC 303 C International Society of Bone and Soft Tissue Pathology...p CC 301 International Society of Gynecological Pathologists...p CC 225 North American Society of Head and Neck Pathology...p CC 304 Rodger C. Haggitt Gastrointestinal Pathology Society...p CC Hemisfair 1 Society for Hematopathology...p CC Hemisfair 2&3 3:30 PM - 5:00 PM COMPANION SOCIETY MEETING History of Pathology Society...p CC 302 C 5:30 PM - 7:30 PM FELLOWSHIP FAIR...p CC 221 ABC 7:30 PM - 9:30 PM EVENING SPECIALTY CONFERENCES Evening Specialty Conference - Genitourinary Pathology...p CC Hemisfair 1 Evening Specialty Conference - Ophthalmic Pathology...p CC 303 C Evening Specialty Conference - Pathologist in Training...p.68...CC 221 D Evening Specialty Conference - Pediatric Pathology...p CC 303 AB 7:30 PM - 10:30 PM COMPANION SOCIETY MEETINGS American Society for Cytopathology...p CC 301 American Society of Dermatopathology...p CC 302 AB Association for Molecular Pathology...p CC 304 International Society of Breast Pathology...p CC 225 6

33 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION MONDAY, MARCH 6, :00 AM - 3:00 PM MENTORS AT THE TABLE HOSPITALITY ROOM... CC 220 Cantilever 8:00 AM - 9:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: Odontogenic Cysts and Tumors...p RC Conf. Room 11 Interactive Microscopy: Diagnostic Dilemmas in Skin Adnexal Tumor Pathology...p RC Conf. Room 5 Interactive Microscopy: Fatty Tumors of the Retroperitoneum...p RC Conf. Room 6 8:00 AM - 12:00 PM PROFFERED PAPERS Proffered Papers Section A - Genitourinary Pathology...p CC SNB 3&4 Proffered Papers Section B - Breast Pathology...p CC Hemisfair 1 Proffered Papers Section C - Cytopathology...p CC 225 Proffered Papers Section D - Gastrointestinal Pathology...p CC Hemisfair 3 Proffered Papers Section E - Gynecologic Pathology...p CC 304 Proffered Papers Section F - Techniques...p CC 301 Proffered Papers Section G - Pulmonary Pathology...p CC 302 Proffered Papers Section H - Potpourri...p CC 303 8:00 AM - 12:00 PM SPECIAL COURSES Clinical Application of Next Generation Sequencing for the Managment of Patients with Solid Tumors...p CC 22 Facebook, Twitter, Instagram, et al: Everything a Pathologist Needs to know to be a Social Media Pro...p CC Hemisfair 2 9:30 AM - 12:00 PM POSTER SESSIONS Poster Presentations - Monday AM...p CC Hall 1 10:00 AM - 11:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: Lymphoma Mimics: What You Don t Know Can Hurt Them...p RC Conf. Room 6 Interactive Microscopy: Key Concepts in Neoplasms of the Eye and Ocular Adnexa: A Practical Approach...p RC Conf. Room 11 Interactive Microscopy: Practical Approaches in Interpretation of Renal Mass Biopsy...p RC Conf. Room 5 12:00 PM - 1:00 PM HOT TOPICS Hot Topics in Pathology 01-Gastrointestinal Pathology...p RC Conf. Room 1-4 1:00 PM - 3:00 PM PROFFERED PAPERS Proffered Papers Section A - Genitourinary Pathology...p CC SNB 3&4 Proffered Papers Section B - Pulmonary Pathology...p CC Hemisfair 1 Proffered Papers Section C - Hematopathology...p CC 225 Proffered Papers Section D - Breast Pathology...p CC Hemisfair 3 Proffered Papers Section E - Kidney/Renal Pathology...p CC 304 Proffered Papers Section F - Head and Neck Pathology...p CC 301 Proffered Papers Section G - Quality Assurance...p CC 302 Proffered Papers Section H - Endocrine Pathology...p CC 303 1:00 PM - 5:00 PM SPECIAL COURSES Tumor Immunology: Implications for TNM Staging and Therapeutics...p CC 221 The Insider s Guide to Quality and Safety...p CC Hemisfair 2 1:00 PM - 4:30 PM POSTER SESSIONS Poster Presentations - Monday-PM...p CC Hall 1 7

34 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION 1:30 PM - 3:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Endometrial Pathology-Selected Challenging and Informative Cases...p RC Conf. Room 6 Interactive Microscopy: Practical Approach to Papillary Problems and Other Dilemmas in Breast Core Needle Biopsy Interpretation...p RC Conf. Room 11 Interactive Microscopy: Unusual and Problem Cases in Head and Neck Cytopathology...p RC Conf. Room 5 4:30 PM - 5:30 PM SPECIAL LECTURE Nathan Kaufman-Timely Topics: Platforms, Diagnosis and Disease: An Evolution Rooted in Pathology...p.96...CC SNB 2-4 4:30 PM - 6:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Glioma Diagnosis-2017: What Pathologists Need to Know...p RC Conf. Room 6 Interactive Microscopy: What Can the Placenta Tell Us?...p RC Conf. Room 11 Interactive Microscopy: Morphology vs. Molecular Markers in GI Biopsy Diagnosis: How Not to Get Tripped Up When Integrating Results!...p RC Conf. Room 5 7:30 PM - 9:30 PM EVENING SPECIALTY CONFERENCES Evening Specialty Conference - Bone and Soft Tissue Pathology...p CC 221 Evening Specialty Conference - Cytopathology...p CC 301 Evening Specialty Conference - Hematopathology...p CC 225 Evening Specialty Conference - Liver Pathology...p CC 302 TUESDAY, MARCH 7, :00 AM - 3:00 PM MENTORS AT THE TABLE HOSPITALITY ROOM... CC 220 Cantilever 8:00 AM - 9:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: An Approach to Intraoperative Consultation in Neuropathology...p RC Conf. Room 6 Interactive Microscopy: Look at that Bug! Interesting Infectious Disease Cases...p RC Conf. Room 11 Interactive Microscopy: High Risk Non-Melanoma Skin Cancers: Lessons from UV-Drenched New Zealand...p RC Conf. Room 5 8:00 AM - 12:00 PM PROFFERED PAPERS Proffered Papers Section A - Genitourinary Pathology...p CC Hemisfair 1 Proffered Papers Section B - Breast Pathology...p CC Hemisfair 3 Proffered Papers Section C - Hematopathology...p CC 225 Proffered Papers Section D - Gastrointestinal Pathology...p CC 221 Proffered Papers Section E - Gynecologic Pathology...p CC 304 Proffered Papers Section F - Cytopathology...p CC 301 Proffered Papers Section G - Bone and Soft Tissue Pathology...p CC 302 Proffered Papers Section H - Liver Pathology...p CC 303 8:00 AM - 5:15 PM SPECIAL COURSE Molecular Diagnostic and Genomic Applications in Cancer: A Primer for the Pathologist...p CC Hemisfair 2 9:30 AM - 12:00 PM POSTER SESSIONS Poster Presentations - Tuesday-AM...p CC Hall 1 10:00 AM - 11:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: A Practical Approach to Endoscopic Ultrasound Guided Fine Needle Aspiration Biopsy...p RC Conf. Room 6 Interactive Microscopy: Diagnostic Issues in DLBCL: A 2017 Perspective...p RC Conf. Room 11 Interactive Microscopy: Head and Neck Pathology: New Insights and Entities...p RC Conf. Room 5 8

35 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION 12:00 PM - 1:00 PM HOT TOPICS Hot Topics in Pathology 02-Breast Pathology...p RC Conf. Room :00 PM - 1:45 PM INTERNATIONAL ACADEMY OF PATHOLOGY SYMPOSIUM...p GH Lone Star Ballroom B 1:00 PM - 2:45 PM PROFFERED PAPERS Proffered Papers Section A - Informatics...p CC Hemisfair 1 Proffered Papers Section B - Autopsy/Cardiovascular...p CC Hemisfair 3 Proffered Papers Section C - Neuropathology...p CC 225 Proffered Papers Section D - Gastrointestinal Pathology...p CC 221 Proffered Papers Section E - Dermatopathology...p CC 304 Proffered Papers Section F - Pancreas...p CC 301 Proffered Papers Section G - Hematopathology...p CC 302 Proffered Papers Section H - Pathobiology...p CC 303 1:00 PM - 4:30 PM POSTER SESSIONS Poster Presentations - Tuesday-PM...p CC Hall 1 1:30 PM - 3:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Challenging Gestational Trophoblastic Lesions-Morphology and Beyond...p RC Conf. Room 6 Interactive Microscopy: Don t Be Duped! Look-alikes in Genitourinary Pathology...p.90...RC Conf. Room 11 Interactive Microscopy: Sneaky GI Biopsies with Hidden Diagnoses: Lessons in Applying a Systematic Approach...p RC Conf. Room 5 4:15 PM - 5:50 PM SPECIAL LECTURE Maude Abbott Legacy and USCAP Honors: Prostate Cancer: Then and Now...p.28, 96...CC SNB 2-4 4:30 PM - 6:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Lung Cancer Classification: Controversies and Challenges...p RC Conf. Room 6 Interactive Microscopy: Mesenchymal Tumors of the Breast: A Conceptual Framework for the Practicing Pathologist...p RC Conf. Room 11 Interactive Microscopy: Correlation of Tumorous and Non-Tumorous Conditions of Bones and Joints with Clinical Imaging: How does the pathology create the imaging features and what you need to know about them...p RC Conf. Room 5 6:00 PM - 7:30 PM GENERATION U RECEPTION (Registrants and guests invited)... GH TEXAS BALLROOM 7:30 PM - 9:30 PM EVENING SPECIALTY CONFERENCES Evening Specialty Conference - Cardiovascular Pathology...p CC 301 Evening Specialty Conference - Dermatopathology...p CC 302 Evening Specialty Conference - Neuropathology...p CC 303 Evening Specialty Conference - Surgical Pathology...p CC SNB 3&4 WEDNESDAY, MARCH 8, :00 AM - 9:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: An Approach to Problematic Vascular Tumors: Benign, Borderline, Malignant and Pseudo Malignant...p RC Conf. Room 6 Interactive Microscopy: Uncommon Types of Invasive Mammary Carcinoma...p RC Conf. Room 11 Interactive Microscopy: When and How to Use Molecular Studies in the Diagnosis of Melanocytic Lesions...p RC Conf. Room 5 9

36 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION 8:00 AM - 12:00 PM SHORT COURSES ** For short courses see ticket for room assignment SC02-Molecular Diagnostics in Cytopathology: Opportunities, Limitations and Pitfalls... p.99 SC06-Diagnostic Dilemmas in Neoplastic and Non-Neoplastic Bone Pathology... p.99 SC08-The Pathologist s Role in Guiding Breast Cancer Treatment in the Era of Neoadjuvant Therapy... p.99 SC15-Practical Ocular Pathology for Pathologists... p.99 SC16-Surgical Pathology Diagnostic Error Prevention... p.99 SC22-Making Comments Count: How to Give Effective Feedback... p.99 SC36-The Updated WHO Classification of Myeloid Neoplasms: A Practical Approach to Genetically-Defined and Not-So-Well Defined Entities... p.99 SC38-Common Diagnostic Dilemmas in Head and Neck Pathology: Pitfalls, Pearls, and Clinical Insights... p.99 SC60-Surgical Pathology and Cytopathology of the Pancreas and Ampulla... p.99 8:00 AM - 5:30 PM LONG COURSE Prostate Pathology: Practical Issues...p CC SNB 3&4 9:00 AM - 12:00 PM POSTER SESSIONS Poster Presentations - Wednesday-AM...p CC Hall 1 10:00 AM - 11:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: Diagnostic Challenges in Head and Neck Surgical Pathology...p RC Conf. Room 11 Interactive Microscopy: Thymic Epithelial Tumors and its Mimickers, Challenges and Pitfalls of Anterior Mediastinal Tumors...p RC Conf. Room 6 Interactive Microscopy: Peculiar Polyps: Diagnostics of Less Common Colorectal Lesions and Awareness of Their Clinical Associations...p RC Conf. Room 5 12:00 PM - 1:00 PM HOT TOPICS Hot Topics in Pathology 03-Immunohistochemistry...p RC Conf. Room 1-4 1:00 PM - 4:00 PM POSTER SESSIONS Poster Presentations: Wednesday-PM...p CC Hall 1 1:30 PM - 3:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Frozen Section in Ovarian and Peritoneal Lesions: Challenges and Controversies...p RC Conf. Room 6 Interactive Microscopy: Tricky Thyroid Tumors...p RC Conf. Room 11 Interactive Microscopy: Tumor and Tumor-like Proliferations of the Spleen...p RC Conf. Room 5 1:30 PM - 5:30 PM SHORT COURSES ** For short courses see ticket for room assignment SC07-It s Not as Bad as it Looks: Pairs of Look-Alike Lesions in Surgical Neuropathology... p.100 SC19-Melanocytic Lesions: A Practical Approach to Diagnosis, Adjunctive Molecular Studies and Appropriate Therapy/Management... p.100 SC23-Surgical and Molecular Pathology of Thyroid Neoplasia... p.100 SC31-Doing More with Less: A Cytology-Histology Correlation of Pulmonary Masses... p.100 SC32-Predictive Biomarkers: Lessons from Clinical Trials... p.100 SC37-Head and Neck Pathology in the Human Papillomavirus Era: A Crash Course... p.100 SC42-Difficult Diagnoses in Pediatric Hematopathology... p.100 SC48-Problematic Areas in the Pathology of the Uterine Cervix... p.100 SC49-Practical Approach to Molecular Diagnosis of Bone and Soft Tissue Tumors... p

37 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION 4:30 PM - 6:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Recognizing Early Oral Cancer, High-risk Precursor Lesions and Mimics...p RC Conf. Room 11 Interactive Microscopy: Interpretation of Intestinal Biopsy in the Era of Precision Medicine...p RC Conf. Room 6 Interactive Microscopy: Urinary Tract Cytopathology: Using the Paris System to Improve Your Practice...p RC Conf. Room 5 7:30 PM - 9:30 PM EVENING SPECIALTY CONFERENCES Evening Specialty Conference - Breast Pathology...p CC 221 AB Evening Specialty Conference - Gastrointestinal Pathology...p CC 221 CD Evening Specialty Conference - Infectious Disease Pathology...p CC 225 CD Evening Specialty Conference - Renal Pathology...p CC 225 AB THURSDAY, MARCH 9, :00 AM - 9:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: Sneaky Cancers and Their Mimics...p RC Conf. Room 6 Interactive Microscopy: Diagnostic Pitfalls in Prostate Pathology...p RC Conf. Room 11 Interactive Microscopy: The 2015 American Thyroid Association Guidelines: The Role of the Surgical Pathologist in Management of Differentiated Thyroid Cancer...p RC Conf. Room 5 8:00 AM - 11:30 AM SHORT COURSES ** For short courses see ticket for room assignment SC04-Autopsy in the 21st Century: An Update for Pathologists Performing Hospital Autopsies Today... p.101 SC05-The Nerve of Some Nerve Sheath Tumors! A Practical Approach to Common Problems in Surgical Pathology... p.101 SC17-Introducing the WHO 2016 Classification of Testicular Tumors: A Synthesis of Molecular and Morphologic Data... p.101 SC18-Diagnostic Criteria of the Paris System for Reporting Urinary Cytology: An Outcomes and Risk Based System... p.101 SC21-Practical Molecular Diagnostics for the Practicing Surgical Pathologist... p.101 SC29-Practical Issues and Clinical Implications in Urinary Bladder Pathology... p.101 SC34-Non-Invasive Nightmares in Breast Pathology... p.101 SC43-Medical Liver Biopsies: Translating Morphologic Patterns into Meaningful Pathology Reports... p.101 SC44-Shedding Light on the Gray Zones of Neoplastic Lung Pathology... p.101 SC51-Common Questions in Gastrointestinal Pathology: Pitfalls and Pearls from Daily Consensus Conference... p.102 SC53-From Pixels to Diagnosis: Introduction to Digital Pathology and Image Analysis... p.102 SC54-Practical Informatics Solutions for Anatomic Pathology Quality Management... p.102 SC57-Translocations and Mutations and Rearrangements, Oh my! The Practical Application of Molecular Techniques in Gynecologic Pathology... p :00 AM - 11:30 AM INTERACTIVE MICROSCOPY Interactive Microscopy: Mesenchymal Tumors of the Uterus: An Update in Classification, Immunostains, and Differential Diagnosis...p RC Conf. Room 6 Interactive Microscopy: Surgical Pathology of Pancreatobiliary Tract...p RC Conf. Room 11 Interactive Microscopy: Pathology of Common Interstitial Lung Diseases- The Essentials for Practicing Pathologists...p RC Conf. Room 5 12:00 PM - 1:00 PM HOT TOPICS Hot Topics in Pathology 04-Dermatopathology...p RC Conf. Room

38 SCHEDULE & GENERAL INFO MEETING AT A GLANCE MEETING AT A GLANCE TIME SESSION PAGE # LOCATION 1:30 PM - 3:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Accurate Diagnosis of Renal Tumor Types: Not Just an Academic Exercise...p RC Conf. Room 6 Interactive Microscopy: Medical Liver Biopsies-How to Stay Out of Trouble...p RC Conf. Room 11 Interactive Microscopy: Diagnosing Histologically Subtle, Yet Clinically Significant, Breast Lesions on Needle Core Biopsies...p RC Conf. Room 5 1:00 PM - 4:30 PM SHORT COURSES ** For short courses see ticket for room assignment SC03-Uses and Limitations of Immunohistochemistry and other Adjunctive Studies in Breast Pathology... p.103 SC09-Challenging Frozen Sections: When Do I Stick My Neck Out and How Far?... p.103 SC11-Contemporary Cardiovascular Pathology from Grossing Bench to Bedside: How Emerging Ancillary Tools Are Transforming the Field... p.103. SC24-Bacterial Infection and The Kidney: Diagnostic Difficulties in Kidney Biopsies... p.103 SC25-Colorectal Dysplasia in IBD: Diagnosis, Implications, and Pitfalls... p.103 SC27-A Pattern-Based Approach to the Diagnosis of Soft Tissue Tumors... p.103 SC30-Diagnosis of Renal Neoplasms Using Integrated Histologic, Cytologic and Molecular Approaches in the Era of Precision Medicine... p.103 SC39-Bone Marrow Manifestations of Systemic Disease... p.103 SC52-Difficult Endometrial Biopsies: Malignancy, Mimics, Molecules, and Mishaps... p.103 SC55-A Practical Approach to Infectious Disease Pathology... p.103 SC56-Nerve and Muscle Biopsies - A Patient-Centered Approach for the General Pathologist... p.104. SC59-Occupationally Related Pleural and Pulmonary Disorders in the 21st Century: Challenges, Pitfalls and No-Nos... p.104 SC62-Nodal Mestastases in Head and Neck Lesions: Where s the Primary?... p.104 4:30 PM - 6:00 PM INTERACTIVE MICROSCOPY Interactive Microscopy: Diagnostic Challenges in Cutaneous Soft Tissue Tumors...p RC Conf. Room 6 Interactive Microscopy: Overcoming Stage Fright in Lung Cancer: Making Sense of Histologic Parameters that Matter...p RC Conf. Room 11 Interactive Microscopy: Using The 2016 WHO Classification of CNS Tumors to Inform Molecular Testing...p RC Conf. Room 5 7:30 PM - 9:30 PM EVENING SPECIALTY CONFERENCES Evening Specialty Conference - Gynecologic Pathology...p CC 221 Evening Specialty Conference - Head and Neck/Endocrine Pathology...p CC 301 Evening Specialty Conference - Pulmonary Pathology...p CC 225 AB FRIDAY, MARCH 10, :00 AM - 11:30 AM SHORT COURSES ** For short courses see ticket for room assignment SC12-Medical Renal Pathology for the General Surgical Pathologist... p.105 SC14-Biopsies of Mediastinal Lesions: Challenges, Pitfalls and Practical Tips... p.105 SC20-Challenging Cases in Thyroid Cytopathology: How Can Ultrasound Findings and Molecular Tests Help?... p.105. SC26 -Colonic Polyps-Daily Problems Only Pathologists Understand... p.105 SC35-Going with the Flow of Bile: An Update on Tumors of the Liver, Bile Ducts and Gallbladder... p.105 SC40-Hematolymphoid Lesions at the Borderline Between Benign and Malignant-Finding Your Way Out of Uncertainty... p.105 SC41-Expanding the Differential Diagnosis in Urologic Pathology: Controversies and New Entities... p.105 SC47-Late Intrauterine Demise: Placental and Fetal Postmortem Pathology... p.105 SC50-Clinical Realities of Next-Generation Sequencing... p.105 1:00 PM - 4:30 PM SHORT COURSES SC10-Diagnostic Challenges in Prostate Pathology... p.106 SC28-Pulmonary Infections: Morphologic and Molecular Tips for the Surgical Pathologist... p.106. SC33-Ovarian Carcinoma: An Update on Histotype Diagnosis, Primary Site Assignment, and Staging... p.106. SC45-Workshop on Problematic Ductal Proliferations of the Breast... p.106 SC46-Open Confession is Good for the Soul: Memorable Mistakes and What We ve Learned... p

39 SCHEDULE & GENERAL INFO FLOOR PLANS CONVENTION HALL FLOOR PLAN Stars at Night Ballroom HemisFair Ballroom Meeting Rooms Meeting Rooms Exhibit Halls 1-4B Bridge Hall Lila Cockrell Theatre Main Lobby/ Business Center West Lobby Meeting Rooms The LDR Grotto 13

40 SCHEDULE & GENERAL INFO FLOOR PLANS MARRIOTT RIVERCENTER FLOOR PLAN 14

41 SCHEDULE & GENERAL INFO FLOOR PLANS MARRIOTT RIVERWALK FLOOR PLAN 15

42 SCHEDULE & GENERAL INFO FLOOR PLANS GRAND HYATT FLOOR PLAN 2nd Floor 16

43 SCHEDULE & GENERAL INFO FLOOR PLANS GRAND HYATT FLOOR PLAN 3rd Floor 4th Floor 17

44 SCHEDULE & GENERAL INFO FLOOR PLANS EXHIBIT HALL FLOOR PLAN 1st Level HENRY B. GONZÀLEZ CONVENTION CENTER 18

45 POSTER PICKUP & POSTER VIEWING STATION Poster Pick-up Location: Call4Posters and iposters, Exhibit Hall 1 in the Henry B. Gonzales Convention Center. The hours are Monday & Tuesday 7:00 AM 5:00 PM, and Wednesday, 7:00 AM 3:00 PM. Posters that were created or submitted for printing and shipping using Learner s Digest International Call4Posters may be picked up at their section. All poster presenters have the option of submitting their posters electronically (free of charge) and having them posted on the USCAP website in the iposters, where they will be available for viewing after the meeting. Please visit the iposters booth for details. USCAP OPERATIONS The United States and Canadian Academy of Pathology USCAP West 500 South Palm Canyon Drive, Suite 321 Palm Springs, CA p. (760) f. (760) USCAP East 404 Town Park Blvd., Suite 201 Evans, GA p. (706) f. (706) David B. Kaminsky, MD, FIAC Executive Vice President [email protected] Darlynne L. Baki Director of Operations USCAP West [email protected] Tina Bowie Membership Services Assistant [email protected] Krista M. Cairns Educational Program Coordinator Annual Meeting [email protected] Denice Chinn Educational Program Coordinator Stand-alone Meetings [email protected] La Toya Collier Educational Program Assistant [email protected] Christian Giangreco Digital Products Coordinator/ Information Technology [email protected] Stacie Hargett Assistant Meeting Planner [email protected] Carolyn Lane Director of Membership Services [email protected] Paul Lewin Director of International Development [email protected] Travis Newman Managing Director [email protected] Teresa Powers Membership Services Coordinator [email protected] Deborah Waterhouse Interactive Coordinator [email protected] Nancy West Director of Meeting Services [email protected] 19

46 SCHEDULE & GENERAL INFO PAST PRESIDENTS James Carroll W. G. MacCallum A. S. Warthin R. M. Pearce A. S. Warthin O. Klotz W. M. L. Coplin James Ewing F. B. Mallory James F. Coupal H. E. Robertson George R. Callender Victor Jacobsen William Boyd V. H. Cornell Carl V. Weller James E. Ash Tracy B. Mallory William H. Feldman Samuel R. Haythom Ralph D. Lillie Everett L. Bishop James E. Ash G. Lyman Duff Granville A. Bennett James B. McNaught Averill A. Liebow Harold L. Stewart Jesse E. Edwards Edward B. Smith William O. Russell Chapman H. Binford Robert E. Stowell F. W. Wiglesworth Benjamin Castleman John B. Hazard J. Lowell Orbison David E. Smith Henry D. Moon A. James French Robert H. More Joshua L. Edwards Edward A. Gall T. C. Jones William Christopherson F. K. Mostofi Nathan Kaufman Richard E. Palmer Murray R. Abell Jack M. Layton Benjamin F. Trump Jack P. Strong William Hartmann Kenneth M. Earle Leland D. Stoddard Bernard M. Wagner F. Stephen Vogel David M. Robertson Robert McCluskey John Yardley Robert Leader Ronald S. Weinstein Cecilia Fenoglio-Preiser David F. Hardwick Costan W. Berard Peter A. Ward Ramzi S. Cotran Hector Battifora William Gardner Richard L. Kempson Sharon W. Weiss Elaine S. Jaffe Harvey Goldman Deborah Powell Ronald DeLellis Louis P. Dehner Virginia A. LiVolsi Ricardo V. Lloyd Sylvia L. Asa Henry D. Appelman Christopher P. Crum Victor R. Reuter Richard J. Zarbo Stuart J. Schnitt Gregory N. Fuller Linda D. Ferrell Jeffrey L. Myers Celeste N. Powers John R. Goldblum Past Secretary-Treasurers Maude Abbott James E. Ash Ruell Sloan Harold Stewart F. K. Mostofi Leland D. Stoddard Nathan Kaufman F. Stephen Vogel Fred G. Silva Bruce R. Smoller 20

47 SCHEDULE & GENERAL INFO IN MEMORIAM SHORT COURSES THESE SOULS WERE RECALLED FROM THE WORLD AND USCAP BUT REMAIN FOREVER IN OUR MEMORIES AND WHEN MY TIME IS UP HAVE I DONE ENOUGH? WILL THEY TELL MY STORY? NATHAN KAUFMAN, M.D. PRESIDENT SECRETARY TREASURER LIN-MANUEL MIRANDA: HAMILTON STEPHEN ALLEN, MD JOHNSTON R. BARR, MD EDWARD J. BENZ, SR, MD RONALD S. BERARDI, MD VIVEK BHARGAVA, MD WILLIAM BLANC, MD DONALD BROCK, MD BRUCE BROWN, MD BRIAN T. COLLINS, MD ASSAAD DAOUD, MD WILLIAM L. DRAKE, JR, MD RICHARD EISENBERG, MD EMMANUEL FARBER, MD BARBARA FLORENTINE, MD JOHN FUERY, MD PAUL GIKAS, MD FAIRFIELD GOODALE, MD WILLIAM HARTMANN, MD (President ) WILLIAM HAWK, MD LLOYD RAYMOND HERSHBERGER, MD ANNE D. HOOPER, MD ROBERT V.P. HUTTER, MD VIOLET JIJI, MD DAVID S. JOHNSON, MD DAGMAR KALOUSEK, MD LOUIS KASZA, DVM, PHD NATHAN KAUFMAN, MD (President ; and Secretary-Treasurer ) GEORGE B. KENT, JR, MD WALI KHAN, MBBS GORDON K. KLINTWORTH, MD SIDNEY KOBERNICK, MD IRENA KOPROWSKA, MD ROBERT LANNIGAN, MD JONATHAN LARA, MD JACK M. LAYTON, MD (President ) MARGARET LITTMAN, MD GLENN MARTIN, MD A.JULIO MARTINEZ, MD HSIEN-MING MENG, MD M.S.N. MURTHY, MD DENNIS E. OSE, MD G. BARRY PIERCE, MD JAMES A. PITCOCK, MD CASSIUS PLAIR, MD HAROLD M. PRICE, MD RODERICK ROSS, MD DAVID ROWLANDS, MD BENITO RYBAK, MD RANJIT SACHDEV, MD CALVIN SAMPSON, MD HAROLD SCHUMACHER, MD TETSUO SHIMAMURA, MD HISHASHI SHINOZUKA, MD RICHARD T. SMITH, MD JOHN E. STOPKA, MD GLEN TODD, VMD, PHD J. ALLAN TUCKER, MD JOHANNA VAN DER BEL-KAHN, MD KARL H. WEGNER, MD JOSEPH WILLIAMS, MD RAYMOND YESNER, MD RAYMOND ZASTROW, MD EUGENE G. ZUZGA, DO 21

48 BOARD & COMMITTEE MEMBERS EXECUTIVE COMMITTEE TERM ENDING N. Volkan Adsay, M.D., President 2017 Christopher Fletcher, M.D., FRCPath, President Elect 2017 Wendy L. Frankel, M.D., Vice President 2017 John R. Goldblum, M.D., Past President 2017 John Sinard, M.D., Ph.D., Secretary 2020 David John Grignon, M.D., Treasurer 2019 David B. Kaminsky, M.D., FIAC Executive Vice President BOARD OF DIRECTORS TERM ENDING Julia C. Iezzoni, M.D Audrey J. Lazenby, M.D Suzanne Z. Powell, M.D Sanja Dacic, M.D., Ph.D Daniel A. Arber, M.D Marisa R. Nucci, M.D Laura C. Collins, M.D John A. Hart, M.D EDUCATION COMMITTEE MEMBERS TERM ENDING Laura W. Lamps, M.D., Chair 2017 Alyssa M. Krasinskas, M.D Melinda E. Sanders, M.D Paul E. Wakely, Jr., M.D Anthony (Tony) Yachnis, M.D Rhonda K. Yantiss, M.D Amy Chadburn, M.D John D. Reith, M.D Raja R. Seethala, M.D Aleodor (Doru) Andea, M.D., MBA 2019 Michelle S. Hirsch, M.D., Ph.D Carol F. Farver, M.D Meera R. Hameed, M.D Rish Pai, M.D., Ph.D Anil Parwani, M.D., Ph.D., MBA 2020 Ashley M. Cimino-Mathews, M.D James R. Cook, M.D., Ph.D Lakshmi Priya Kunju, M.D Vinita Parkash, MBBS 2020 Sub-committee Chairs / Pathologists-In-Training Shree G. Sharma, M.D., Informatics Subcommittee 2020 Jason L. Hornick, M.D., Ph.D., Abstract Assignment Committee 2017 Marisa R. Nucci, M.D., Subcommittee for Unique Live Course Offerings 2017 Eva Vertes George, M.D., Pathologist-In-Training 2017 Michael Gerald Drage, M.D., Pathologist-In-Training 2017 Bradley (Brad) J. Quade, M.D., Ph.D., CME Subcommittee 2017 Steven D. Billings, M.D., Short Course Coordinator, Chair IM Sub-committee 2017 David B. Kaminsky, M.D., FIAC (Ex-Officio) 22

49 SCHEDULE & GENERAL INFO BOARD & COMMITTEE MEMBERS ABSTRACT ASSIGNMENT COMMITTEE SHORT COURSES TERM ENDING Jason L. Hornick, M.D., Ph.D. Chair 2017 Justine Barletta, M.D Leona Doyle, M.D Brad Ferris, M.D Kristin Jensen, M.D Dylan V. Miller, M.D Elizabeth Morgan, M.D Rajiv Patel, M.D Bobbi S. Pritt, M.D Charles M. Quick, M.D Raga Ramachandran, M.D., Ph.D Shree G. Sharma, M.D Maria Westerhoff, M.D Sean R. Williamson, M.D Justin Bishop, M.D Daniel Dye, M.D Ryan Gill, M.D., Ph.D David Hwang, M.D., Ph.D Robin D. LeGallo, M.D Juan-Miguel Mosquera, M.D Ericka Olgaard, D.O Alexandros Polydorides, M.D., Ph.D Michael Roh, M.D., Ph.D Sandro Santagata, M.D., Ph.D Laura Wood, M.D., Ph.D EDUCATION INFORMATICS SUBCOMMITTEE TERM ENDING Shree G. Sharma, M.D., Chair 2020 Rish K. Pai, M.D., Ph.D Darren T. Wheeler, M.D Liron Pantanowitz, M.D Gaurav Sharma, M.D Hunter Hardy, M.D Laura W. Lamps, M.D. (Ex-Officio) David B. Kaminsky, M.D., FIAC (Ex-Officio) CME SUBCOMMITTEE MEMBERS TERM ENDING Bradley J. Quade, M.D., Ph.D., Chair 2017 Sara C. Shalin, M.D., Ph.D Yaolin Zhou, M.D. (Fellow) 2017 Amy Chadburn, M.D John D. Reith, M.D Melinda E. Sanders, M.D Yaël K. Heher, M.D., MPH, FRCPC 2019 SUBCOMMITTEE FOR UNIQUE LIVE COURSE OFFERINGS TERM ENDING Marisa Nucci, M.D., Chair 2017 Alyssa M. Krasinskas, M.D Aleodor (Doru) Andea, M.D., MBA 2019 Carol F. Farver, M.D Ashley M. Cimino-Mathews, M.D Raja Seethala, M.D

50 SCHEDULE & GENERAL INFO BOARD & COMMITTEE MEMBERS SUBCOMMITTEE FOR INTERACTIVE MICROSCOPY TERM ENDING Steven D. Billings, M.D., Chair 2018 Laura W. Lamps, M.D Laura C. Collins, M.D Paul E. Wakely, Jr., M.D COURSE DIRECTORS Diagnostic Cytopathology - Ritu Nayar, M.D Diagnostic Pathology Update Adam Bagg, M.D., Co-Director 2019 Diagnostic Pathology Update Rhonda Yantiss, M.D., Co-Director 2021 Interactive Microscopy Steven D. Billings, M.D FINANCE COMMITTEE MEMBERS TERM ENDING Henry Tazelaar, M.D., Chair 2019 Robert P. Hasserjian, M.D Mary S. Richardson, M.D Allen Gown, M.D David J. Grignon, M.D., Treasurer 2019 Eyas M. Hattab, M.D., MBA 2019 Cain McClary, M.D N. Volkan Adsay, M.D. (Ex-Officio) David B. Kaminsky, M.D., FIAC (Ex-Officio) Travis Newman (Managing Director, Accountant) MEMBERSHIP COMMITTEE MEMBERS TERM ENDING Tarik Tihan, M.D., Ph.D., Chair 2017 Esmeralda C. Marginean, M.D Robert M. Najarian, M.D Marwan A. Yared, M.D., (Representative for Resident Advisory Committee) 2017 Kristie White, M.D Patricia E. Goldhoff, M.D., MA (Pathologist-In-Training) 2018 Cristina Magi-Galluzzi, M.D., Ph.D Lydia P. Howell, M.D Alejandro Ariel Gru, M.D Sonam Prakash, M.D David B. Kaminsky, M.D., FIAC (Ex-Officio) Carolyn Lane (Director of Membership) 24

51 SCHEDULE & GENERAL INFO BOARD & COMMITTEE MEMBERS SOCIAL MEDIA SUBCOMMITTEE TERM ENDING Jerad M. Gardner, M.D Samson W. Fine, M.D Roseann I. Wu, M.D, M.P.H Sean R. Williamson, M.D Nicole D. Riddle, M.D Xiaoyin Sara Jiang, M.D Nathan Lee, M.D Matthew Wasco, M.D Rashna Meunier, M.D Raul Gonzalez, M.D Genevieve (Eve) M. Crane, M.D., Ph.D David B. Kaminsky, M.D., FIAC (Ex-Officio) Ethan Kaminsky (KAMPROD) Christian Giangreco (Staff, Information Technology) Stacie Hargett (Staff) PUBLICATIONS COMMITTEE MEMBERS TERM ENDING Murray B. Resnick, M.D., Ph.D., Chair 2019 Elaine Jaffe, M.D Jeffrey Goldsmith, M.D Rajiv M. Patel, M.D Brian Rubin, M.D. Ph.D Romil Saxena, MBBS, FRCPath 2019 David B. Kaminsky, M.D., FIAC (Ex-Officio) JOURNAL EDITORS LABORATORY INVESTIGATION TERM ENDING Gene P. Siegal, M.D., Ph.D. 1/1/09 12/31/18 Robert W. Hardy, M.D., Ph.D. 1/1/09 12/31/18 Alexander Lazar, M.D., Ph.D. 7/1/13 12/31/18 Catherine Ketcham, Ph.D., Managing Editor JOURNAL EDITORS MODERN PATHOLOGY TERM ENDING John N. Eble, M.D. 5/1/00 6/30/20 Harvey M. Cramer, M.D. 7/1/05 6/30/20 Catherine Ketcham, M.D., Ph.D., Managing Editor 25

52 SCHEDULE & GENERAL INFO BOARD & COMMITTEE MEMBERS FOUNDATION COMMITTEE MEMBERS TERM ENDING Gregory N. Fuller, M.D., Ph.D. Chair 2018 Celeste N. Powers, M.D., Ph.D Linda D. Ferrell, M.D Marie E. Robert, M.D Ann Marie Nelson, M.D Julia A. Bridge, M.D Mary S. Richardson, M.D Steven C. Smith, M.D., Ph.D Martha Bishop Pitman, M.D Esther Oliva, M.D N. Volkan Adsay, M.D. (Ex-Officio) David John Grignon, M.D. (Ex-officio) Treasurer David B. Kaminsky, M.D., FIAC (Ex-Officio) Paul M. Lewin (Director, International Development) USCAP CANADA FOUNDATION TERM ENDING David F. Hardwick, M.D., Chair 2017 Michael F. Allard, M.D Sylvia L. Asa, M.D., Ph.D C. Blake Gilks, M.D John Veinot, M.D Ilan Weinreb, M.D NOMINATING COMMITTEE MEMBERS TERM ENDING John R. Goldblum, Chair 2017 Linda D. Ferrell, M.D Esther Oliva, M.D., Member at Large 2017 Celeste N. Powers, M.D., Ph.D Julia A. Bridge, M.D Laura W. Lamps, M.D. (Ex-Officio) David B. Kaminsky, M.D., FIAC (Ex-Officio) YOUNG INVESTIGATOR AWARD COMMITTEE TERM ENDING Audrey J. Lazenby, M.D., Chair 2017 Julia C. Iezzoni, M.D Cristina R. Antonescu, M.D Celina G. Kleer, M.D Sanja Dacic, M.D David B. Kaminsky, M.D., FIAC (Ex-Officio) CASTLEMAN AWARDS COMMITTEE TERM ENDING William C. Faquin, M.D., Ph.D., Chair 2018 Mary S. Richardson, M.D Victor E. Reuter, M.D Gregory N. Fuller, M.D., Ph.D Martha Pitman, M.D David Rimm, M.D., Ph.D David N. Louis, M.D., (Ex-Officio) N. Volkan Adsay, M.D. (Ex-Officio) David B. Kaminsky, M.D., FIAC (Ex-Officio) 26

53 SCHEDULE & GENERAL INFO BOARD & COMMITTEE MEMBERS GOLDMAN AWARDS COMMITTEE TERM ENDING Stuart Schnitt, M.D., Chair N/A Jeffrey E. Saffitz, M.D., Ph.D. N/A Laura W. Lamps, M.D. N/A N. Volkan Adsay, M.D. N/A Steven D. Billings, M.D. N/A David B. Kaminsky, M.D., FIAC (Ex-Officio) STOWELL-ORBISON AWARDS COMMITTEE TERM ENDING Omar Hameed, M.D., Chair 2019 Deborah J. Chute, M.D Leona A. Doyle, M.D Wayne Tam, M.D., Ph.D Andrew M. Bellizzi, M.D VOGEL AWARDS COMMITTEE TERM ENDING Esther Oliva, M.D., Chair 2019 Megan S. Lim, M.D., Ph.D Adam Bagg, M.D Anthony Yachnis, M.D Kristen A. Atkins, M.D John N. Eble, M.D., (Ex-Officio) Gene P. Siegal, M.D., Ph.D., (Ex-Officio) David B. Kaminsky, M.D., FIAC (Ex-Officio) AMERICAN MEDICAL ASSOCIATION TERM ENDING Nicole D. Riddle, M.D., Delegate 2017 Daniel C. Zedek, M.D., (Alternate) 2018 Michael O. Idowu, M.D., (CPT Advisor) 2019 David S. Wilkinson, M.D., Ph.D., (Alternate) 2019 David B. Kaminsky, M.D., Pathology Section Representative AMERICAN REGISTRY OF PATHOLOGY Ronald A. DeLellis, M.D. BIOLOGICAL STAIN COMMISSION Paul E. Swanson, M.D. INTERSOCIETY COMMITTEE ON PATHOLOGY INFORMATION Margaret M. Grimes, M.D. INTERSOCIETY PATHOLOGY COUNCIL David B. Kaminsky, M.D., FIAC N. Volkan Adsay, M.D. 27

54 SCHEDULE & GENERAL INFO BOARD & COMMITTEE MEMBERS PROGRAM DIRECTORS SECTION OF ASSOCIATION SHORT COURSES OF PATHOLOGY CHAIRS (PRODS) Suzanne Z. Powell, M.D. MOC ADVISORY COMMITTEE, AMERICAN BOARD OF PATHOLOGY Jordi J. Rowe, M.D. MAUDE ABBOTT LEGACY AND USCAP HONORS TUESDAY, MARCH 7, 2017 HENRY B. GONZÁLEZ CONVENTION CENTER - STARS AT NIGHT BALLROOM 4:15 P.M. - 5:50 P.M. STOWELL-ORBISON... Dr. Laura W. Lamps AUTOPSY AND SURGICAL PATHOLOGY... Dr. Teri Longacre CASTELMAN AWARD... Dr. Vania Nosé VOGEL AWARD... Dr. Esther Oliva DISTINGUISHED PATHOLOGIST AWARD... Dr. N. Volkan Adsay MOSTOFI AWARD... Dr. N. Volkan Adsay THE PRESIDENT S AWARD... Dr. N. Volkan Adsay RAMZI COTRAN YOUNG INVESTIGATOR AWARD... Dr. Jeffrey A. Golden HARVEY GOLDMAN MASTER TEACHER AWARD... Dr. Stuart J. Schnitt DR. L. CLARKE JR. & ELAINE F. STOUT ENDOWMENT AWARD... Dr. N. Volkan Adsay DR. FLORABEL G. MULLICK TRAVEL AWARD... Dr. Greg Fuller 5:00 PM INTRODUCTION OF MAUDE ABBOTT LECTURER AND PRESENTATION OF MAUDE ABBOTT MEDALLION... Dr. N. Volkan Adsay 5:05-5:50 PM: THE MAUDE ABBOTT LECTURE... Dr. Peter A. Humphrey 28

55 2017 BUSINESS MEETING AGENDA SATURDAY, MARCH 4, 2017 HENRY B. GONZÁLEZ CONVENTION CENTER CANTILEVER 3:30 P.M. - 4 P.M. 1. CALL TO ORDER... Dr. N. Volkan Adsay 2. INTRODUCTION... Dr. N. Volkan Adsay 3. APPROVAL OF MINUTES, 2016 BUSINESS MEETING... Dr. N. Volkan Adsay 4. REPORT OF THE PRESIDENT General Information Recognition of Dignitaries Announcements Bylaws Change 5. REPORT OF THE EXECUTIVE VICE PRESIDENT... Dr. David B. Kaminsky 6. REPORT OF THE EDUCATION COMMITTEE... Dr. Laura W. Lamps 7. REPORT OF THE FINANCE COMMITTEE... Dr. David Grignon 8. REPORT OF THE MEMBERSHIP COMMITTEE/RAC... Dr. Tarik Tihan 9. REPORT OF THE FOUNDATION COMMITTEE... Dr. Greg Fuller 10. REPORT OF THE PUBLICATIONS COMMITTEE... Dr. Murray Resnick 11. REPORT OF THE NOMINATING COMMITTEE... Dr. John Goldblum 12. ELECTION OF OFFICERS... Dr. John Goldblum 13. INSTALLATION OF THE PRESIDENT... Dr. N. Volkan Adsay 14. PRESENTATION OF THE PRESIDENT S MEDAL TO THE PAST-PRESIDENT... Dr. N. Volkan Adsay 15. REPORT OF THE IAP... Dr. David Hardwick Future Congresses (Amman, Jordan 2018; Glasgow, United Kingdom, 2020) 16. OTHER BUSINESS... Dr. N. Volkan Adsay 17. ADJOURNMENT... Dr. N. Volkan Adsay 29

56 2016 BUSINESS MEETING MINUTES TUESDAY, MARCH 15, 2016 WASHINGTON STATE CONVENTION CENTER, HALL 4E 3:30 PM 5:00 PM 2016 The program preliminary to the Annual Business Meeting opened at 3:41pm with video interviews by several key USCAP faculty members addressing Next Generation Learning. The President, John Goldblum, M.D. and the Executive Vice-President, David B. Kaminsky, M.D. were introduced. Dr. Goldblum thanked everyone for attending and then discussed how USCAP is conscious of changes in the way medical professionals learn. The traditional classroom teaching style is no longer the preferred method, particularly for millennial pathologists, who relate more to interactive, digital, on demand methodologies to grow their medical knowledge. Dr. Kaminsky spoke on the clinical implications of our knowledge and refining communication style, how we educate to meet the demands of how we learn. Video interviews with key USCAP faculty members underscored the importance of the paradigm shift in the ways new learners can receive access to knowledge and interactive learning. The Interactive Center is a prime example of how USCAP is leading the way to this new method of learning. The importance of the microscope is crucial in the learning of a pathologist. A video of the transformation of the Powers-Sanchez Interactive Center and Linder Learning Center was presented. Dr. Kaminsky described the construction of the Linder Learning Center and how it completes USCAP s vision of delivering education by a variety of versatile methods utilizing the broadcast studio and conference theater. USCAP s segment on The Discovery Channel s television series, Innovations was screened following introduction by Dr. Kaminsky. USCAP won the Silver Telly Award, Telly s highest honor. Dr. Goldblum described the process over the past year to create a more aesthetic and functional website with enhanced connectivity, representing USCAP s Smart Network. He then described creation of the Social Media Sub-committee under the leadership of Dr. Jerad Gardner, which energetically responds to the social demands of our members. Dr. Kaminsky described the redesign of the Ambassador program to attract pathologists-in-training to serve as diplomats for USCAP and propel them through their career tracks. He announced creation of the President s Helix, a group of Past-Presidents with historical wisdom, who desired to reconnect with the modern Academy. 1. CALL TO ORDER DR. JOHN R. GOLDBLUM The formal 2016 USCAP Business Meeting was called to order by Dr. Goldblum on Tuesday March 15, 2016 at 4:07 pm. 2. ADOPTION OF AGENDA DR. JOHN R. GOLDBLUM A motion (requested by Dr. John Goldblum) CARRIED to adopt the agenda. 3. APPROVAL OF MINUTES, 2015 BUSINESS MEETING DR. JOHN R. GOLDBLUM A motion CARRIED to approve the minutes (previously posted on the USCAP website and included in the program book) of the 2015 Annual Business Meeting. 4. REPORT OF THE PRESIDENT Recognition of Dignitaries Dr. Goldblum introduced several dignitaries in attendance and thanked them for attending the meeting. 5. REPORT OF THE EXECUTIVE VICE PRESIDENT DR. DAVID B. KAMINSKY Dr. Kaminsky thanked the staff for their hard work and dedication to the Academy. His informal report was represented by the video informational presentation about the state of the Academy and the narrative descriptions delivered by him and Dr. Goldblum immediately prior to calling to order the Business Meeting. 30

57 SCHEDULE & GENERAL INFO 2016 BUSINESS MEETING MINUTES 6. REPORT OF THE EDUCATION COMMITTEE DR. LAURA LAMPS Dr. Laura Lamps presented a summary of the 2016 Annual Meeting Statistics. There were 4,709 registrants from 84 countries. She stated that 3,054 abstracts were submitted with 2,096 accepted: an acceptance rate of 69%; these were triaged to 1,816 posters and 280 platform presentations. Dr. Lamps enumerated that the total number of possible CME s per person is 55.5 hours and SAMs per person 52.5 hours. She explained the excitement surrounding the new digital products, Interactive Microscopy, the Interactive Center, the opportunity to enhance mentoring and a reinvigorated subcommittee on Informatics. Dr. Lamps ended with a slide on a Formula for Success, which contained all the above-referenced totals. 7. REPORT OF THE FINANCE COMMITTEE DR. WENDY FRANKEL Financial success allows the USCAP to build its future, with investments like the interactive learning center and redesigned website. This growth and diversification of the Academy represents positive change, strengthening our ability to serve our members. A collective effort among the USCAP of Directors, Committees, and Management team working collaboratively resulted in USCAP s achieving strong financial metrics, developing a strong financial position and reinforcing USCAP as the most prestigious provider of continuing medical education for pathologists globally for many years to come. The combined revenues of the Academy totaled $7.2 million last fiscal year with more than 85% directed to fund USCAP programs for our customers and members. With a strong investment portfolio, primarily consisting of a diverse mix of mutual funds, treasury notes and bonds, we continue to achieve our annual targeted rate of return. In November 2015, auditors released their annual report on the Academy finances, which included no errors in management s presentation of the financial statements. 8. REPORT OF THE MEMBERSHIP/RAC COMMITTEES DR. TARIK TIHAN Dr. Tihan thanked the committee members and Dr. Kaminsky for their assistance over the last two years. He explained the structure and terms of the Membership Committee by presenting a list of the committee members. The bylaws change ratified the previous year (re-structuring member categories) has allowed over 70 Ph.D. colleagues to become members of USCAP. The creation of the Membership Passport is encouraging members for life. Dr. Tihan spoke on the revamping of the Ambassador program and he thanked the dedicated staff member Debbie Waterhouse. To assist with additional media support, the creation of the Social Media Sub-committee was developed under the supervision of Dr. Jerad Gardner. Dr. Tihan provided the attendees with graphical representations of the membership database and the demographics of the distribution of the membership. Priorities for 2016 include gathering member demographic data by mining the database, surveys, engaging clinical pathologists, creating members for life, continuing support for the Resident Advisory Sub-committee and Social Media committee, developing a member gift program and assisting the Executive Vice-President with the Ambassador program. 9. REPORT OF THE USCAP FOUNDATION DR. GREG FULLER Dr. Fuller thanked the Foundation Committee for their dedication in making this another successful year for the USCAP Foundation. The Foundation has adopted the goal of improving health globally by leveraging the power of philanthropy. The priorities of the Foundation are innovating education, fostering new pathologists and promoting global health. Dr. Fuller further described the importance of the Interactive Center and how the Foundation would play an integral role in its financial support. He reinforced mentorship as a key core value. Dr. Fuller described the several on-going initiatives of the Foundation such as partnering with the Cleveland Clinic and Yale for the multi-week clerkship for three young pathologists from Haiti, Paraguay, and Nepal; the Miles-for-Mentors cross-fit edition which was a success (Yoga was proposed for 2017 in San Antonio); provision of travel grants to ten pathologists-in-training to attend the Annual Meeting; and transforming the G program to the G program to provide travel scholarships to 40 pathologists from underserved countries who would not have otherwise had the opportunity to attend the meeting. The Foundation continues to support the West African school and thanked the ASCP for their collaboration on the Africa Calls initiative. Dr. Fuller thanked Dr. Hardwick for the creation of the USCAP Canada Foundation to allow Canadians an opportunity to make tax deductible contributions in support of the educational mission of the USCAP. 31

58 SCHEDULE & GENERAL INFO 2016 BUSINESS MEETING MINUTES 10. REPORT OF THE PUBLICATIONS COMMITTEE DR. MURRAY RESNICK Dr. Resnick began the presentation by stating this has been a very successful year with both journals Modern Pathology and Laboratory Investigation. He acknowledged the partnership between the USCAP and the Nature Publishing Group. Dr. Resnick explained the structure of Laboratory Investigation with its new developments and thanked editor-in-chief Dr. Gene Siegal for his dedication. Laboratory Investigation is among the top three journals devoted to general experimental pathology. Dr. Resnick then explained the structure of Modern Pathology and that it is one of the leading journals devoted to general diagnostic anatomic/surgical pathology. Dr. Resnick announced an unprecedented 4th term of office as editorin-chief by Dr. John Eble. The impact factors of each journal were presented in comparison to competitors. Next, slides for the most cited papers were noted for each journal. The submission process remains strong among competitors. The introduction of Meet the Editors was discussed, which allowed attendees to meet the editors at the Nature exhibit booth. Dr. Resnick ended by thanking Dr. Catherine Ketcham and Martha Simmons as well as the Editorial s and reviewers of LI and MP. 11. REPORT OF THE NOMINATING COMMITTEE AND ELECTION OF OFFICERS DR. CELESTE N. POWERS Dr. Powers began by thanking the members of the committee. Drs. Laura Collins, Marisa Nucci, and John Hart were elected by the membership to three opening positions on the of Directors (created by end-of-terms for three existing members). Dr. Powers also introduced the incoming Vice-President, Dr. Wendy Frankel, and the new Treasurer, Dr. David Grignon. 12. PRESENTATION OF THE PRESIDENT S MEDAL TO THE PAST-PRESIDENT DR. JOHN R. GOLDBLUM Dr. Goldblum presented Dr. Powers with a traditional engraved Medallion to commemorate her presidency. 13. INSTALLATION OF THE PRESIDENT DR. JOHN R. GOLDBLUM Dr. Goldblum introduced the incoming President, Dr. N. Volkan Adsay, and presented him with an engraved gavel. 14. REPORT OF THE IAP DR. DAVID HARDWICK Dr. Hardwick announced that the 2016 IAP Congress would be held on September 24-30th in Cologne, Germany. The 2018 Congress will take place in Amman, Jordan with the 2020 IAP Congress following in Glasgow, Scotland. 15. IN MEMORIAM Dr. David Kaminsky introduced a video presentation honoring those members of the Academy who died during the previous year. Two Past-Presidents, Dr. Bernard Wagner and Dr. F. Stephen Vogel were featured. 16. OTHER BUSINESS DR. JOHN R. GOLDBLUM Dr. Goldblum called for any new business from the floor. There was none. 17. ADJOURNMENT DR. JOHN R. GOLDBLUM The 2016 Annual Business Meeting was adjourned at 4:41 pm. John Sinard, M.D., Ph.D. September 9, 2016 Secretary Date Approved 32

59 SCHEDULE & GENERAL INFO IAP SESSION International Academy of Pathology Postgraduate Education in Pathology: Current Practice and Future Needs Around the Globe TUESDAY MARCH 7, :00 PM 1:45 PM GRAND HYATT, LONESTAR BALLROOM SALON B, 2ND FLOOR MODERATOR: Jane Dahlstrom, MBBS (Hons), PhD, FRCPA, FFOP, FFSc, SFHEA Australian National University Medical School and ACT Pathology, Woden, ACT, Australia SESSION CHAIR: George Kontogeorgos, MD, PhD, G. Gennimatas Athens General Hospital, Hellas, Greece 12:00 PM MIDDLE EAST EXPERIENCE Ghazi Zaatari, MD, American University of Beirut, Beirut, Lebanon 12:20 PM UNITED KINGDOM EXPERIENCE Ray McMahon, BSc, MD, FRCPath, Manchester Royal Infirmary, Manchester, UK 12:40 PM JAPANESE EXPERIENCE Osamu Matsubara, MD, PhD, National Defense Medical College, Tokorozawa, Saitama, Japan 1:00 PM CANADIAN EXPERIENCE Blake Gilks, MD, FRCP, University of British Columbia and Vancouver Coastal Health, Vancouver, British Columbia, Canada 1:20 PM INDIAN EXPERIENCE Vinay Kumar, MBBS, MD, FRCPath, The Pritzker Medical School, University of Chicago, Chicago, IL 33

60 Please note: For Alumni Receptions: You are invited to attend if you are an alumnus, a guest of an alumnus, or a friend of the institution. For Specialty/Companion Society Receptions: You are invited if you are a member of this society or are considering joining the society and wish to learn more about it. All luncheons are by invitation only. GH Grand Hyatt Hotel RC Marriott Rivercenter Hotel RW Marriott Riverwalk Hotel CC Henry B. Gonzalez Convention Center 2017 AFFILIATE EVENTS FRIDAY, MARCH 3RD 8:00 AM - 5:00 PM INT'L ASSOCIATION FOR THE STUDY OF LUNG CANCER RC Salon K (3rd Floor) 6:00 PM - 10:00 PM ADASP COUNCIL MTG & DINNER RC Salon M (3rd Floor) SATURDAY, MARCH 4TH 7:30 AM - 5:00 PM ADASP ANNUAL MEETING RC Conf. Rm. 13/14 (3rd Floor) 8:00 AM - 3:00 PM INT'L ASSOCIATION FOR THE STUDY OF LUNG CANCER RC Salon L (3rd Floor) 8:00 AM - 6:00 PM VHA NATIONAL DX ELECTRON MICROSCOPY RW Bonham (2nd Floor) AD HOC CMTE MEETING 8:30 AM - 12:00 PM CHINA-US PATHOLOGY SYMPOSIUM RC Salon E (3rd Floor) 10:00 AM - 5:00 PM PAPANICOLAOU SOCIETY MEETING RC Conf. Rm. 7 (3rd Floor) 12:00 PM - 1:30 PM ADASP LUNCHEON AND BUSINESS MEETING RC Salon K (3rd Floor) 12:00 PM - 4:00 PM INT'L SOCIETY OF UROLOGICAL PATH COUNCIL MTG RC Conf. Rm. 11 (3rd Floor) 12:00 PM - 6:00 PM CHINESE AMERICAN PATH ASSOC. RC Salon E (3rd Floor) 2:00 PM - 6:00 PM INT'L SOCIETY OF GYN PATHOLOGY EXEC COMM MTG RC Salon D (3rd Floor) 3:00 PM - 5:00 PM PULMONARY PATH SOCIETY COUNCIL MEETING RC Conf. Rm. 12 (3rd Floor) 3:45 PM - 5:45 PM RENAL PATHOLOGY SOCIETY BRD MTG RC Salon C (3rd Floor) 4:00 PM - 6:00 PM INT'L SOCIETY OF UROLOGICAL PATH RECEPTION RC Salon K (3rd Floor) 5:00 PM - 7:00 PM SOC FOR ULTRASTRUCTURAL PATHOLOGY RC Salon A (3rd Floor) EXECUTIVE BUSINESS MTG 5:00 PM - 7:30 PM ASSOCIATION OF INDIAN PATH EXEC CMTE MTG RW Crockett (2nd Floor) 5:00 PM - 7:30 PM PAPANICOLAOU SOCIETY RECEPTION RC Salon L (3rd Floor) 5:30 PM - 7:00 PM ENDOCRINE SOCIETY RECEPTION RC Conf. Rm. 11 (3rd Floor) 5:30 PM - 7:30 PM AFRICAN IAP ASSEMBLY/ASAP GROUP BOARD OF DIRECTORS MTG RC Conf. Rm. 16 (3rd Floor) 5:30 PM - 9:00 PM SOCIETY FOR HEMATOPATH EXECUTIVE COMM MTG RW Travis (2nd Floor) 6:15 PM - 6:45 PM INT'L SOCIETY OF UROLOGICAL PATH AGM MTG CC Hemisfair 1 (3rd Level) SUNDAY, MARCH 5TH 7:00 AM - 8:00 AM ENDOCRINE PATHOLOGY EDITORIAL BOARD MTG GH Bonham A (3rd Floor) 7:00 AM - 10:00 AM SOCIETY FOR HEMEPATH FELLOWSHIP DIRECTORS BREAKFAST RC Salon D (3rd Floor) 7:00 AM - 2:30 PM APC LEADERSHIP MEETING GH Bonham D (3rd Floor) 7:15 AM - 8:30 AM ARTHUR PURDY STOUT SOCIETY COUNCIL BREAKFAST RC Conf. Rm. 2 (3rd Floor) 7:30 AM - 9:00 AM WILEY-DIAGNOSTIC CYTOPATH /ED BOARD MTG RC Conf. Rm. 16 (3rd Floor) 8:00 AM - 12:00 PM DICOM PATHOLOGY WORKING GROUP GH Bonham B (3rd Floor) 8:00 AM - 3:30 PM ASCP RESIDENT'S COUNCIL GH Travis C/D (3rd Floor) 8:00 AM - 5:00 PM MESOTHELIOMA PANEL RC Conf. Rm. 7 (3rd Floor) 10:00 AM - 12:30 PM ASC/IAC SALIVARY GLAND TERMINOLOGY TASK FORCE GH Lonestar Ballroom Salon E (THE MILAN SYSTEM) (2nd Floor) 12:00 PM - 1:30 PM MCGILL UNIVERSITY LUNCHEON RC Conf. Rm. 13/14 (3rd Floor) 1:30 PM - 3:30 PM INTERNATIONAL BREAST PATH MEETING GH Presidio B (3rd Floor) 1:30 PM - 4:30 PM SOC FOR CARDIOVASCULAR PATH EXEC COMM MTG RC Conf. Rm. 16 (3rd Floor) 3:00 PM - 4:00 PM CYTOJOURNAL EDITORIAL BOARD ACTIVITY GH Travis A/B (3rd Floor) 34

61 SCHEDULE & GENERAL INFO AFFILIATE EVENTS SUNDAY, MARCH 5TH...cont. 3:00 PM - 5:00 PM INT'L SOCIETY OF BREAST PATH COMMITTEE MTG RC Conf. Rm. 4 (3rd Floor) 5:00 PM - 6:30 PM LWW - ADVANCES IN ANATOMIC PATH MTG. GH Bonham B (3rd Floor) 5:00 PM - 6:45 PM INT'L SOCIETY OF BREAST PATHOLOGY RECEPTION RC Conf. Rm. 3 (3rd Floor) 5:00 PM - 7:00 PM ARTHUR PURDY STOUT SOCIETY RECEPTION RC Conf. Rm. 2 (3rd Floor) 5:00 PM - 7:00 PM HEAD & NECK PATHOLOGY RECEPTION GH Presidio C (3rd Floor) 5:00 PM - 7:00 PM UNIVERSITY OF WASHINGTON DEPT. OF PATHOLOGY ALUMNI MIXER GH Bonham D (3rd Floor) 5:00 PM - 7:30 PM ASSOCIATION OF INDIAN PATH RECEPTION RC Salon B (3rd Floor) 5:15 PM - 6:30 PM IAC BUSINESS MEETING GH Republic C (4th Floor) 5:30 PM - 6:30 PM IRISH/NORTH AMERICAN PATHOLOGY MTG GH Lonestar Ballroom Salon D (2nd Floor) 5:30 PM - 7:00 PM UPMC FACULTY AND ALUMNI RECEPTION GH Lonestar Ballroom Salon C (2nd Floor) 5:30 PM - 7:30 PM CLEVELAND CLINIC ALUMNI RECEPTION GH Lonestar Ballroom Salon A (2nd Floor) 5:30 PM 7:30 PM DUKE PATHOLOGY ALUMNI RECEPTION GH Seguin (4th Floor) 5:30 PM - 7:30 PM COLUMBIA UNIV. (PRES HOSPITAL) ALUMNI REC. GH Mission A (2nd Floor) 5:30 PM - 7:30 PM FRIENDS OF AFRICA INITIATIVE MEETING GH Lonestar Ballroom Salon B (2nd Floor) 5:30 PM - 7:30 PM GI PATHOLOGY SOCIETY RECEPTION RC Conf. Rm. 8 (3rd Floor) 5:30 PM - 7:30 PM IRANIAN PATHOLOGISTS ASSOCIATION OF NA RECEPTION RC Conf. Rm. 12 (3rd Floor) 5:30 PM - 7:30 PM STANFORD UNIVERSITY RECEPTION RC Salon D (3rd Floor) 5:30 PM - 7:30 PM UNIVERSITY OF MIAMI RECEPTION GH Mission B (2nd Floor) 5:30 PM - 7:30 PM UT SOUTHWESTERN RECEPTION RC Conf. Rm. 1 (3rd Floor) 5:30 PM - 8:00 PM SOCIETY FOR HEMATOPATH RECEPTION RC Conf. Rm 13/14 (3rd Floor) 7:00 PM - 7:20 PM INT'L SOCIETY OF BREAST PATH AGM MTG CC 225 7:00 PM - 8:00 PM HEAD AND NECK JOURNAL BOARD MTG GH Presidio A (3rd Floor) 7:00 PM - 8:00 PM RENAL PATHOLOGY SOCIETY ANNUAL RECEPTION RC Salon K (3rd Floor) 7:00 PM - 12:00 AM UCSF RECEPTION RC Conf. Rm (3rd Floor 8:00 PM - 10:00 PM RENAL PATHOLOGY SOCIETY ANNUAL DINNER RC Salon L (3rd Floor) MONDAY, MARCH 6TH 7:00 AM - 9:00 AM (ELSEVIER) CV PATH EDITORIAL BOARD MEETING RC Conf. Rm. 7 (3rd Floor) 7:00 AM - 9:00 AM HUMAN PATH ASSOCIATE EDITORS MEETING RC Salon J (3rd Floor) 8:00 AM - 10:00 AM MD SURVEY TASK FORCE GH Crockett C/D (4th Floor) 8:00 AM - 10:00 AM TRIG COMMITTEE MEETING GH Independence (3rd Floor) 8:30 AM - 2:30 PM APC CHAIRS LUNCH/MEETING GH Texas Ballroom Salon A (4th Floor) 10:00 AM - 3:00 PM APC PRODS LUNCH/MEETING GH Texas Ballroom Salon E (4th Floor) 10:30 AM - 3:00 PM PANCREATOBILIARY SOCIETY LUNCHEON GH Lonestar Ballroom Salon F (2nd Floor) 11:30 AM - 2:00 PM HUMAN PATH EDITORIAL BOARD MEETING RC Salon J (3rd Floor) 12:00 PM - 1:30 PM INT'L JOURNAL OF GYN PATHOLOGY ED BRD GH Travis C/D (3rd Floor) 12:00 PM - 6:00 PM AFRICAN IAP ASSEMBLY/ASAP GROUP MEETING RC Salon K (3rd Floor) 4:00 PM - 5:30 PM ENUP BOARD MEETING GH Mission B (2nd Floor) 5:00 PM - 6:30 PM ARCHIVES OF PATH RECEPTION RC Salon L (3rd Floor) 5:00 PM - 7:00 PM HOUSTON METHODIST HOSPITAL RESIDENT RECEPTION RC Conf. Rm. 18 (3rd Floor) 5:00 PM - 7:00 PM MT. SINAI ALUMNI RECEPTION GH Texas Ballroom Salon F (4th Floor) 5:00 PM - 7:00 PM UNIVERSITY OF PENNSYLVANIA RECEPTION GH Bonham C (3rd Floor) 5:00 PM - 7:00 PM UNIVERSITY OF TEXAS MEDICAL BRANCH REUNION GH Presidio A (3rd Floor) 5:30 PM - 7:00 PM LABORATORY MEDICINE & PATHOLOGY GH Republic B (4th Floor) (UNIV. OF TORONTO) RECEPTION 5:30 PM - 7:00 PM UMASS MEDICAL SCHOOL ALUMNI RECEPTION RC Salon A (3rd Floor) 5:30 PM - 7:30 PM ALUMNI & FRIENDS OF YALE RECEPTION GH Republic A (4th Floor) 5:30 PM - 7:30 PM ARAB DIVISION OF IAP RECEPTION GH Presidio B (3rd Floor) 5:30 PM - 7:30 PM BRIGHAM AND WOMEN'S HOSPITAL RECEPTION RC Conf. Rm. 7 (3rd Floor) 5:30 PM - 7:30 PM JOHNS HOPKINS RECEPTION RC Salon M (3rd Floor) 5:30 PM - 7:30 PM LATIN AMERICAN PATH FOUNDATION RECEPTION RC Salon C (3rd Floor) 35

62 SCHEDULE & GENERAL INFO AFFILIATE EVENTS MONDAY, MARCH 6TH...cont. 5:30 PM - 7:30 PM MASSACHUSETTS GENERAL RECEPTION RC Conf. Rm. 8 (3rd Floor) 5:30 PM - 7:30 PM MAYO CLINIC ALUMNI ASSOCIATION RECEPTION GH Crockett C/D (4th Floor) 5:30 PM - 7:30 PM MD ANDERSON RECEPTION RC Conf. Rm. 13/14 (3rd Floor) 5:30 PM - 7:30 PM ROSWELL PARK RECEPTION GH Travis C/D (3rd Floor)5:30 PM - 7:30 PM UCLA ALUMNI RECEPTION GH Bonham E (3rd Floor) 5:30 PM - 7:30 PM UNIVERSITY OF ALABAMA AT BIRMINGHAM RECEPTION GH Crockett A/B (4th Floor) 5:30 PM - 7:30 PM UNIVERSITY OF CHICAGO RECEPTION GH Texas Ballroom Salon C (4th Floor) 5:30 PM - 7:30 PM UNIVERSITY OF ROCHESTER MEDICAL CENTER ALUMNI RECEPTION GH Sequin (4th Floor) 5:30 PM - 7:30 PM UNIVERSITY OF VERMONT RECEPTION GH Texas Ballroom Salon D (4th Floor) 5:30 PM - 7:30 PM UNIVERSITY OF WISCONSIN - MADISON PATHOLOGY GH Lonestar Ballroom Salon D DEPT. ALUMNI RECEPTION (2nd Floor) 5:30 PM - 7:30 PM VANDERBILT ALUMNI RECEPTION GH Bonham B (3rd Floor) 5:30 PM - 7:30 PM UNIVERSITY OF MICHIGAN ALUMNI SOCIETY GH Bonham D (3rd Floor) 6:00 PM - 8:00 PM MOFFITT CANCER CENTER RECEPTION RC Conf. Rm. 12 (3rd Floor) 6:00 PM - 8:00 PM NYU SCHOOL OF MEDICINE ALUMNI RECEPTION GH Lonestar Ballroom Salon C (2nd Floor) 6:00 PM - 8:00 PM WASHINGTON UNIVERSITY IN ST. LOUIS RECEPTION RC Salon D (3rd Floor) 8:00 PM - 10:00 PM UNIVERSITY OF MINNESOTA ALUMNI & FRIENDS RECEPTION RC Conf. Rm. 17 (3rd Floor) 9:00 PM - 11:00 PM INT'L ASSN OF CHINESE PATH ANNUAL REC GH Republic C (4th Floor) TUESDAY, MARCH 7TH 7:30 AM - 9:00 AM APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR GH Independence (3rd Floor) MORPHOLOGY ED. BOARD MTG. 7:30 AM - 9:30 AM ANNALS OF DIAGNOSTIC PATH (ELSEVIER) GH Lonestar Ballroom Salon C (2nd Floor) 12:00 PM - 2:00 PM AMERICAN JOURNAL OF SURGICAL PATH ED BOARD GH Travis A/B (3rd Floor) 3:00 PM - 6:00 PM SCVP MEETING GH Bonham D (3rd Floor) 5:30 PM - 7:30 PM BETH ISRAEL DEACONESS HOSPITAL RECEPTION GH Bonham B (3rd Floor) 5:30 PM - 7:30 PM EMORY UNIVERSITY RECEPTION GH Lonestar Ballroom Salon E (2nd Floor) 5:30 PM - 7:30 PM HISTOPATHOLOGY EDITORIAL BOARD RECEPTION GH Travis C/D (3rd Floor) 5:30 PM - 7:30 PM JAPAN NIGHT, JAPANESE DIVISION OF IAP RECEPTION GH Presidio C (3rd Floor) 5:30 PM - 7:30 PM MSKCC ALUMNI RECEPTION GH Travis A/B (3rd Floor) 5:30 PM - 7:30 PM UNC RECEPTION GH Presidio A (3rd Floor) 6:00 PM - 7:30 PM UNIVERSITY OF MARYLAND RECEPTION GH Bonham C (3rd Floor) 36

63 PATHOLOGISTS-IN-TRAINING #IAMUSCAP #USCAP2017

64 MENTORS TABLE at the Here is your opportunity to engage with the rockstars of the pathology world in a casual venue. Topics of Discussion Include... What s concrete about the abstract? #IAMUSCAP how to get into social media Grasping Informatics Global outreach one world of pathology Career Life Cycle of the Pathologist Finding empathy Next Generation Sequencing Women in Medicine Molecular Pathology Mentoring through Interactive Microscopy How to get published! Quality starts during training The patient-centered cytopathology practice Conflict management Monday, March 6, Breakfast Gene P. Siegal, M.D., Ph.D. Carol F. Farver, M.D. Shree Sharma, M.D. Celeste N. Powers, M.D., Ph.D. Marwan Yared, M.D. Laura C. Collins, M.D. Monday, March 6, Lunch Christopher D.M. Fletcher, M.D., FRCPath E. Blair Holladay, Ph.D., SCT(ASCP) Paul Lewin, Director of International Development Jerad Gardner, M.D. Steven D. Billings, M.D. Laura W. Lamps, M.D. Lynette M. Sholl, M.D. Tuesday, March 7, Breakfast Gene P. Siegal, M.D., Ph.D. Rebecca L. Johnson, M.D. Marwan Yared, M.D. Rhonda Yantiss, M.D. Wendy Frankel, M.D. Marisa Nucci, M.D. Richard L. Haspel, M.D. Tuesday, March 7, Lunch Yaël Heher, M.D., MPH, FRCP Rebecca L. Johnson, M.D. Paul Lewin, Director of International Development Shree Sharma, M.D. John R. Goldblum, M.D. Cristina Magi-Galuzzi, M.D., Ph.D. RESIDENTS ON THE VERGE Henry B. Gonzalez Convention Center Cantilever 7:00 A.M. 3:00 P.M.

65 PATHOLOGISTS-IN-TRAINING As the new Chair of the Resident Advisory Subcommittee, I m excited to welcome pathologists-in-training to this sensational and inspiring international meeting in San Antonio, Texas. We have designed this meeting with you in mind. Begin your experience at the special trainee registration and information booth in the lobby of the Henry B. Gonzalez Convention Center. You can t miss the invigorated signage that invokes Moving Information in the Digital Age. The USCAP staff will prepare you to navigate this amazing conference and optimize learning, networking, and Texan-style socializing. Don t miss two programs targeted to your needs and interests. Dr. Richard Haspel s Training Residents in Genomics meets 9 am to 5 pm on Saturday, March 4th and the Pathologists-in-Training Evening Specialty Conference from 7:30 pm to 9:30 pm on Sunday, March 5th. The Pathologists-in-Training and Ambassador Reception will take place in the attractive 220 space at the convention center from 5:30 pm to 7:30 pm on March 4th at the conclusion of the genomics program. Mentors at the Table is your opportunity to meet pathology rock stars and benefit from their mentoring influence and advice during breakfasts and lunches on March 6-7th, also in Room 220 of the convention center. The Fellowship Fair on Sunday evening (March 5th) is your exposure to some of the best subspecialty training opportunities in North America. You can meet faculty and fellowship directors from more than 40 institutions. Check out the Fellowship Fair charts found under this tab designed to help you quickly target your optimal program. There are numerous short courses, the Long Course, Timely Topics Lecture, and the amazing State-of-the Academy presentation that accompanies the prestigious Maude Abbott Lecture by Dr. Peter Humphrey. Our annual Abstract Competition with its many awards attracts the foremost pathology research from around the world. The information is presented by platform sessions and posters. The Ambassador program has been designed to help you navigate the meeting and your career pathways, guiding you to the heart of USCAP for your professional nurturing. Become involved with Dr. Jerad Gardner and his Social Media Committee in generating tweets, Facebook posts, and Instagrams. The USCAP Annual Meeting 2016 tracked almost 29 million twitter impressions! Social and professional networking are woven through numerous receptions, particularly the Generation U party. This year, the Foundation sponsored Travel Awards for fifteen pathologists-in-training ($1000 per scholarship) for facilitating attendance at the Annual Meeting. If you re not already a member of USCAP, you can become a Trainee Member for annual dues of $35 through residency and fellowship, which entitles you to many benefits including significant discounts on registration fees and an annual subscription to Modern Pathology or Laboratory Investigation. Become a better pathologist. Immerse yourselves in the kinetic energy and information resources at the world s largest pathology meeting. Marwan Yared, M.D. Chair, Resident Advisory Subcommittee Associate Professor, Baylor College of Medicine 37

66 PATHOLOGISTS-IN-TRAINING 2017 USCAP FELLOWSHIP FAIR Sunday, March 5, :30-7:30 PM CC Room 221 ABC # SUB SPECIALTIES 1 BLOOD BANKING / TRANSFUSION 2 BONE & SOFT TISSUE 3 BREAST 4 CANCER BIOMARKER 5 CARDIOVASCULAR PATHOLOGY 6 CHEMICAL PATHOLOGY 7 CLINICAL BIOCHEMICAL GENETICS 8 CLINICAL BIOCHEMISTRY 9 CLINICAL CHEMISTRY 10 CLINICAL CYTOGENETICS 11 CLINICAL IMMUNOLOGY 12 CLINICAL MICROBIOLOGY 13 CLINICAL MOLECULAR GENETICS 14 CYTOGENETICS 15 CYTOPATHOLOGY 16 DERMATOPATHOLOGY 17 ENDOCRINE 18 EXPERIMENTAL 19 FORENSIC 20 GENITOURINARY 21 GENOMIC PATHOLOGY 22 GI AND LIVER PATHOLOGY 23 GYNECOLOGIC PATHOLOGY 24 HEAD & NECK 25 HEMATOPATHOLOGY 26 HLA 27 IMMUNOPATHOLOGY 28 INFORMATICS 29 LABORATORY MEDICINE 30 MEDICAL GENETICS 31 MICROBIOLOGY 32 MOLECULAR GENETICS 33 MULTIDISCIPLINARY SUBSPECIALTY PATHOLOGY 34 MUSCULOSKELETAL PATHOLOGY 35 NEUROPATHOLOGY 36 ONCOLOGIC MOLECULAR 37 ONCOLOGIC SURGICAL PATHOLOGY 38 OPTHALAMIC PATHOLOGY 39 ORTHOPEDIC PATHOLOGY 40 PEDIATRIC PATHOLOGY 41 PERINATAL & DEVELOPMENTAL 42 PULMONARY PATHOLOGY 43 RENAL PATHOLOGY 44 RESEARCH 45 SARCOMA 46 SELECTIVE PATHOLOGY 47 SPECIAL COAGULATION 48 SURGICAL PATHOLOGY 49 THORACIC PATHOLOGY 50 UROPATHOLOGY 51 VIROLOGY INSTITUTION (TABLE #) FELLOWSHIPS OFFERED BAYLOR COLLEGE OF MEDICINE (#14) 1, 9, 15, 16, 25, 32, 35, 40, 48 BROWN UNIVERSITY ALPERT MEDICAL SCHOOL 3, 22, 23, 35, 40, 41, 48, 52 (#6) CLEVELAND CLINIC PATHOLOGY AND 1, 2, 5, 8, 12, 15, 16, 20, 22, 25, 32, 52 LABORATORY MEDICINE (#37) DARTMOUTH-HITCHCOCK MEDICAL CENTER (#26) 1, 9, 15, 16, 25, 32 EAST CAROLINA UNIVERSITY - BRODY SCHOOL OF 15, 19, 28, 48 MEDICINE (#39) EMORY UNIVERSITY (#29) 1, 15, 16, 19, 22, 25, 31, 32, 35, 40, 48 HOUSTON METHODIST HOSPITAL (#3) 1, 3, 9, 15, 23, 25, 26, 32, 35, 38, 48 ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 3, 15, 16, 17, 20, 22, 23, 24, 25, 32, 35, 43 (#40) INDIANA UNIVERSITY SCHOOL OF MEDICINE (#23) 15, 16, 19, 20, 22, 25, 31, 35, 48 LOYOLA UNIVERSITY MEDICAL CENTER (#16) 15, 16, 25, 48 MAYO CLINIC, ROCHESTER (#8) 1, 2, 3, 5, 12, 15, 22, 25, 32, 35, 42, 43, 47, 48 MD ANDERSON CANCER CENTER (#7) 1, 3, 4, 15, 16, 20, 22, 23, 25, 32, 45, 48, 49 MEMORIAL SLOAN KETTERING CANCER CENTER 3, 15, 16, 18, 20, 22, 23, 25, 32, 37, 49 (#10) MOFFITT CANCER CENTER (#41) 15, 16, 22, 25, 32, 48 MONTEFIORE MEDICAL CENTER / ALBERT 15, 16, 22, 25, 32, 52 EINSTEIN COLLEGE OF MEDICINE (#38) NORTHWELL HEALTH (#1) 15, 25, 48 NYU LANGONE MEDICAL CENTER (#17) 15, 22, 25, 32, 50, 52 OREGON HEALTH & SCIENCE UNIVERSITY 15, 25, 32, 35, 48 DEPARTMENT OF PATHOLOGY (#42) PATHOLOGYOUTLINES.COM, INC. (#9) FELLOWSHIP ADVERTISING WEBSITE ROSWELL PARK CANCER INSTITUTE (#15) 15, 37 RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL (#36) 25 THE CHILDREN'S HOSPITAL OF PHILADELPHIA (#30) 40 THE JOHNS HOPKINS UNIVERSITY SCHOOL OF 1, 9, 15, 20, 22, 23, 25, 31, 32, 35, 43, 48, MEDICINE - DEPARTMENT OF PATHOLOGY (#4) TUFTS MEDICAL CENTER (#31) 48 UNIVERSITY OF ALABAMA AT BIRMINGHAM (#12) 15, 19, 25, 32, 35, 48 UNIVERSITY OF ARKANSAS FOR MEDICAL 15, 16, 25, 48 SCIENCES (#27) UNIVERSITY OF CALIFORNIA SAN FRANCISCO 1, 15, 16, 22, 23, 25, 32, 35, 43, 48 (#24) UNIVERSITY OF CHICAGO (#33) 1, 9, 15, 16, 22, 24, 25, 31, 32, 43, 48, 49 UNIVERSITY OF MARYLAND (#2) 15, 25 UNIVERSITY OF MIAMI SCHOOL OF MEDICINE/ 1, 3, 15, 20, 22, 23, 24, 25, 32, 40 JACKSON MEMORIAL HOSPITAL (#35) UNIVERSITY OF MICHIGAN (#28) 1, 2, 3, 6, 15, 16, 19, 20, 22, 23, 25, 26, 28, 32, 35, 40, 42, WOMEN'S PATHOLOGY 38

67 PATHOLOGISTS-IN-TRAINING 2017 USCAP FELLOWSHIP FAIR # SUB SPECIALTIES 1 BLOOD BANKING / TRANSFUSION 2 BONE & SOFT TISSUE 3 BREAST 4 CANCER BIOMARKER 5 CARDIOVASCULAR PATHOLOGY 6 CHEMICAL PATHOLOGY 7 CLINICAL BIOCHEMICAL GENETICS 8 CLINICAL BIOCHEMISTRY 9 CLINICAL CHEMISTRY 10 CLINICAL CYTOGENETICS 11 CLINICAL IMMUNOLOGY 12 CLINICAL MICROBIOLOGY 13 CLINICAL MOLECULAR GENETICS 14 CYTOGENETICS 15 CYTOPATHOLOGY 16 DERMATOPATHOLOGY 17 ENDOCRINE 18 EXPERIMENTAL 19 FORENSIC 20 GENITOURINARY 21 GENOMIC PATHOLOGY UNIVERSITY OF NEBRASKA, MEDICAL CENTER 12, 22, 25, 32, 48 (#34) UNIVERSITY OF ROCHESTER MEDICAL CENTER 1, 3, 15, 20, 22, 25 (#18) UNIVERSITY OF UTAH (#19) 7, 9, 10, 11 13, 15, 22, 25, 30, 31, 32, 35, 40, 48 UNIVERSITY OF VIRGINIA HEALTH SCIENCES (#32) 1, 9, 15, 16, 23, 25, 35 UNIVERSITY OF WASHINGTON - DEPARTMENT OF PATHOLOGY (#25) UNIVERSITY OF WISCONSIN-MADISON/UW HEALTH (#11) UTHSCSA - UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO (#22) 1, 2, 3, 9, 15, 16, 19, 20, 22, 23, 25, 31, 32, 35, 40, 43, 48 1, 15, 25, 48 1, 15, 25, 48 VANDERBILT UNIVERSITY MEDICAL CENTER (#13) 1, 9, 12, 13, 15, 22, 25, 32, 35, 40, 43, 48 VIRGINIA COMMONWEALTH UNIVERSITY HEALTH 15, 25, 32, 48 SYSTEMS, DEPARTMENT OF PATHOLOGY (#21) WASHINGTON UNIVERSITY SCHOOL OF MEDICINE, 1, 15, 16, 22, 24, 25, 32, 48 DEPARTMENT OF PATHOLOGY AND IMMUNOLOGY (#5) YALE UNIVERSITY SCHOOL OF MEDICINE (#20) 1, 3, 15, 17, 20, 22, 23, 24, 25, 31, 32, GI AND LIVER PATHOLOGY 23 GYNECOLOGIC PATHOLOGY 24 HEAD & NECK 25 HEMATOPATHOLOGY 26 HLA 27 IMMUNOPATHOLOGY 28 INFORMATICS 29 LABORATORY MEDICINE 30 MEDICAL GENETICS 31 MICROBIOLOGY 32 MOLECULAR GENETICS 33 MULTIDISCIPLINARY SUBSPECIALTY PATHOLOGY 34 MUSCULOSKELETAL PATHOLOGY 35 NEUROPATHOLOGY 36 ONCOLOGIC MOLECULAR 37 ONCOLOGIC SURGICAL PATHOLOGY 38 OPTHALAMIC PATHOLOGY 39 ORTHOPEDIC PATHOLOGY 40 PEDIATRIC PATHOLOGY 41 PERINATAL & DEVELOPMENTAL 42 PULMONARY PATHOLOGY 43 RENAL PATHOLOGY 44 RESEARCH 45 SARCOMA 46 SELECTIVE PATHOLOGY 47 SPECIAL COAGULATION 48 SURGICAL PATHOLOGY 49 THORACIC PATHOLOGY 50 UROPATHOLOGY 51 VIROLOGY 52 WOMEN'S PATHOLOGY 39

68 RESIDENT ADVISORY COMMITTEE RESIDENT ADVISORY COMMITTEE MEMBER TERM ENDING Marwan Yared, M.D., Chair 2019 Amber Nolan, M.D., Ph.D Drew G. Davis, M.D Kurt W. Fisher, M.D., Ph.D Lindsay Alpert, M.D Martin J. Magers, M.D Lauren Ritterhouse, M.D., Ph.D Sakir Humayun ( Hume ) Gultekin, M.D Benjamin C. Calhoun, M.D., Ph.D Jessica Davis, M.D Erin N. Faber, D.O., MBA, MA 2019 Emilio Madrigal, D.O Sandra J. Shin, M.D

69 COMPANION MEETINGS #IAMUSCAP #USCAP2017

70 THE COMPANY WE KEEP Surround yourself with the dreamers and the doers, the believers and the thinkers - Edmund Lee Subspecialty companions to USCAP impact learning and connectivity from a collective, diverse knowledge base. Twenty-nine Societies comprise a unique sphere of influence dramatically enhancing the USCAP experience. AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS AMERICAN ASSOCIATION OF OPHTHALMIC ONCOLOGISTS AND PATHOLOGISTS AMERICAN COLLEGE OF VETERINARY PATHOLOGISTS AMERICAN SOCIETY FOR CLINICAL PATHOLOGY AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY AMERICAN SOCIETY OF CYTOPATHOLOGY AMERICAN SOCIETY OF DERMATOPATHOLOGY ARTHUR PURDY STOUT SOCIETY OF SURGICAL PATHOLOGISTS ASSOCIATION FOR MOLECULAR PATHOLOGY ASSOCIATION FOR PATHOLOGY INFORMATICS BINFORD-DAMMIN SOCIETY OF INFECTIOUS DISEASE PATHOLOGISTS COLLEGE OF AMERICAN PATHOLOGISTS ENDOCRINE PATHOLOGY SOCIETY HANS POPPER HEPATOPATHOLOGY SOCIETY HISTORY OF PATHOLOGY SOCIETY INTERNATIONAL SOCIETY OF BONE & SOFT TISSUE PATHOLOGY INTERNATIONAL SOCIETY OF BREAST PATHOLOGY INTERNATIONAL SOCIETY OF GYNECOLOGICAL PATHOLOGISTS INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY NORTH AMERICAN SOCIETY FOR HEAD AND NECK PATHOLOGY PALEOPATHOLOGY CLUB PAPANICOLAOU SOCIETY OF CYTOPATHOLOGY PULMONARY PATHOLOGY SOCIETY RENAL PATHOLOGY SOCIETY RODGER C. HAGGITT GASTROINTESTINAL PATHOLOGY SOCIETY SOCIETY FOR CARDIOVASCULAR PATHOLOGY SOCIETY FOR HEMATOPATHOLOGY SOCIETY FOR ULTRASTRUCTURAL PATHOLOGY Thanks to our Companion Societies and attendees for making the USCAP Annual Meeting the world s largest pathology event. See you next year in Canada!

71 COMPANION MEETINGS COMPANION SOCIETY MEETING AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS Pineal Region Tumors SATURDAY, MARCH 4, :00 PM 10:00 PM CC 221 A-C MODERATORS: Christine Fuller, MD, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Adekunle Adesina, MD, PhD, Baylor University, Texas Children s Hospital, Houston, TX COURSE DESCRIPTION: To address the difficult and challenging issues that can be encountered by both the practicing surgical pathologists and neuropathologists alike. The regional approach will facilitate the understanding of the practical issues and differential diagnostic problems that arise in actual practice. Many practicing pathologists encounter surgical neuropathology specimens and are in a position to provide intraoperative consultations and final diagnoses on a broad spectrum of neurosurgical specimens, while they are not necessarily trained in the field of neuropathology. These talks will provide a framework for them to formulate their work-up and diagnoses, while educating them on the intricacies and pitfalls of various tumors seen in the pineal region. Upon completion of this educational activity, participants should be able to: Describe the classification of pineal parenchymal tumors and WHO grading Identify the major tumors encountered in the pineal region and their differential diagnosis Effectively avoid pitfalls arising from the unusual histologic appearances inherent to the pineal region Become familiar with the tumors with papillary features arising in the pineal region 7:00 PM OPENING REMARKS Christine Fuller, MD, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Adekunle Adesina, MD, PhD, Baylor University, Texas Children s Hospital, Houston, TX 7:10 PM PINEAL PARENCHYMAL TUMORS Tarik Tihan, MD, PhD, University of California San Francisco, San Francisco, CA 7:50 PM GERM CELL TUMORS Eyas Hattab, MD, University of Louisville, Louisville, KY 8:30 PM PAPILLARY TUMOR OF THE PINEAL REGION AND THE DIFFERENTIAL DIAGNOSIS OF PAPILLARY TUMORS Brent Orr, MD, PhD, St. Jude Children s Research Hospital, Memphis, TN 9:10 PM PINEAL CYST, GLIAL AND OTHER RARE TUMORS Hannes Vogel, MD, Stanford University Medical Center, Stanford, CA 41

72 COMPANION MEETINGS COMPANION SOCIETY MEETING ASSOCIATION FOR PATHOLOGY INFORMATICS The March Towards Precision Medicine: Value of Pathology Informatics in Creation of Pixel and Genome Pipelines to Enhance the Diagnostic Process SATURDAY, MARCH 4, :00 PM 10:00 PM CC 221 D MODERATOR: Anil Parwani, MD, PhD, MBA, The Ohio State Universality, Columbus, OH COURSE DESCRIPTION: Digital pathology, image-based and genomic analytics is being increasingly appreciated as a critical area of pathology practice. The goal of the symposium is to present several aspects of digital pathology, next generation sequencing and image based analytics, and to apply these approaches too current and future pathology practice. As digital pathology and next generation sequencing becomes more mainstream, pathologists and pathologists in training need to not only understand the applications of these new technologies in routine practice, but how these technologies will change the pathology practice. Topics will focus on creating pipelines of image and genomic data through advanced techniques such as digital imaging and next generation sequencing. Focus will also be on leveraging data analytics utilizing both genomic and digital image pipelines. Very little exposure to these concepts is available in most pathology practices. In summary, this symposium will provide useful insights into the creation of pipelines of information from images and genomic sequencing and how these pipelines require an understanding of pathology informatics in providing solution, robust infrastructure and analytical tools. Upon completion of this educational activity, participants should be able to: Have a greater familiarity with the most recent advancement in the growing field of Digital Pathology and image analysis Understand the requirements for next generation sequencing of pathology specimens and system implementation Understand the opportunities afforded by the availability of digital pathology for computational analysis and creation of decision support analytical tools Apply concepts of digital image analysis to clinical practice and research such as multiplex analysis of pathology samples Present practical examples of next generation sequencing applications and the support of clinical diagnosis and precision medicine 7:00 PM INTRODUCTION AND SYMPOSIUM OVERVIEW: EMERGING TRENDS IN PATHOLOGY INFORMATICS Anil Parwani, MD, PhD, MBA, The Ohio State University, Columbus, OH 7:15 PM RE-IMAGINING THE MICROSCOPE TO FACILITATE COLLABORATION AND INTEGRATION OF BIG DATA IN MEDICINE Bruce Levy, MD, CPE, Geisinger Health System, Danville, PA 8:00 PM CREATION OF A PIXEL PIPELINE AND THE NEED FOR IMAGE ANALYSIS TO IMPROVE WORKFLOW AND INCREASE ADOPTION OF DIGITAL PATHOLOGY FOR CLINICAL USE Andrew J. Evans, MD, PhD, PRCPC, Toronto General Hospital, Toronto, ON, Canada 8:45 PM INFORMATICS CHALLENGES IN THE CREATION OF A GENOMIC PIPELINE USING NEXT GENERATION SEQUENCING: CURRENT STATE AND FUTURE DIRECTIONS Somak Roy, MD, University of Pittsburgh Medical Center, Pittsburgh, PA 9:15 PM COMPELLING USE-CASES FOR IMMEDIATE DEPLOYMENT OF IMAGE-BASED ANALYTICS IN DIGITAL WHOLE SLIDE IMAGING PATHOLOGY WORKFLOW Ulysses Balis, MD, University of Michigan Health System, Ann Arbor, MI 42

73 COMPANION MEETINGS COMPANION SOCIETY MEETING ENDOCRINE PATHOLOGY SOCIETY The Value and Pitfalls of Ki67 in the Diagnosis of Endocrine Neoplasms SATURDAY, MARCH 4, :00 PM 10:00 PM CC HEMISFAIR 2 MODERATORS: Hironobu Sasano, MD, PhD, Tohoku University School of Medicine, Sendai, Japan Ricardo V. Lloyd, MD, PhD, The University of Wisconsin, Madison, WI COURSE DESCRIPTION: Ki67 labeling index (LI) has been established as the reliable method of demonstrating the proliferative activity of tumor cells and is replacing classical mitotic index in potential classification, prediction of clinical outcome and therapeutic response to adjuvant or neoadjuvant therapy and others. Therefore, the exact value of Ki67 LI has been frequently asked by clinical oncologists managing the patients with cancer patients. In particular, among endocrine neoplasms, Ki67 LI plays indispensable roles in surgical pathology diagnosis of neuroendocrine neoplasms in pancreas, GI tract and lung, pituitary tumors and adrenal neoplasms, especially adrenocortical carcinoma. However, it is also true that the methodology of obtaining Ki67 LI has not been standardized especially in where to be evaluated, hot spots versus average and how to be counted, eye ball versus computer assisted image analysis. Therefore, in this companion symposium, the value and pitfalls of Ki67 labeling index will be summarized in lung, pancreas and GI tract neuroendocrine neoplasms, pituitary tumors and adrenal neoplasms. Upon completion of this educational activity, participants should be able to: Describe the importance and limitations of Ki67 labeling index in endocrine tumors including the value of threshold in discerning malignancy in individual endocrine tumors, possible overlap between benign and malignant endocrine tumors, its value as surrogate markers for adjuvant and neoadjuvant therapy in specific endocrine tumors Identify the threshold of Ki67 labeling index for discerning malignancy in endocrine tumors according to WHO classification and other guidelines. The proposed threshold of Ki67 LI in selecting specific medical therapy in endocrine neoplasms to communicate with clinical oncologists or endocrinologists. The importance of standardization of Ki67 LI as well as its limitations Incorporate the absolute Ki67 labeling index number in surgical pathology report of endocrine neoplasms including the methodology of immunostaining and scoring 7:00 PM INTRODUCTION: KI67; AVERAGE VERSUS HOT SPOTS; EYE BALL VERSUS IMAGE ANALYSIS Hironobu Sasano, MD, PhD, Tohoku University School of Medicine, Sendai, Japan 7:15 PM KI67 IN PANCREATIC NEN OR NEUROENDOCRINE NEOPLASM ACCORDING TO WHO 2017 Günter Klöppel, MD, PhD, Consultation Center for Pancreatic and Endocrine Tumors, München, Germany 7:45 PM KI67 IN PITUITARY TUMORS: WHAT INFORMATION COULD WE OBTAIN? Robert Yoshiyuki Osamura, MD, PhD, International University of Health and Welfare Mita Hospital, Tokyo, Japan 8:00 PM THE ROLE OF KI67 IN PULMONARY NEUROENDOCRINE TUMORS William Travis, MD, Memorial Sloan Kettering Cancer Center, New York, NY 8:30 PM THE VALUE AND PITFALLS OF KI67 LABELING INDEX IN GASTROINTESTINAL NEN OR NEUROENDOCRINE NEOPLASM Stefano La Rosa, MD, PhD, Institut Universitaire de Pathologie, Lausanne, Switzerland 8:55 PM ADVANTAGES AND LIMITATIONS OF ASSESSING PROLIFERATION IN ADRENAL TUMORS FOR DIAGNOSIS AND PROGNOSIS Thomas Giordano, MD, PhD, University of Michigan, Ann Arbor, MI 9:20 PM SUMMARY OF TALKS Ricardo V. Lloyd, MD, PhD, University of Wisconsin School of Medicine and Public Health, Madison, WI 43

74 COMPANION MEETINGS COMPANION SOCIETY MEETING PAPANICOLAOU SOCIETY OF CYTOPATHOLOGY The Current State of Thyroid Fine-Needle Aspiration: Considerations, Discussions and Conclusions SATURDAY, MARCH 4, :00 PM 10:00 PM CC HEMISFAIR 3 MODERATOR: Zubair W. Baloch, MD, PhD, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA COURSE DESCRIPTION: The PSC companion program for 2017 USCAP annual meeting will address new aspects and challenges that may lead to modification in the diagnosis and classification of thyroid FNA specimens. The subject experts presenting at this companion session will deliver educational content designed to highlight the importance of the pathologist's role in the diagnosis and further intervention and treatment of thyroid nodules. The first speaker will address various cytomorphologic features that distinguish between thyroid nodules classified as suspicious or consistent with papillary thyroid carcinoma. The second presentation will focus on how to make sense and incorporate the "American Thyroid Association" guidelines for management of thyroid nodules into daily practice of thyroid cytology. The third presenter will provide an overview of what is new and exciting in the field of molecular testing of thyroid FNA specimens with emphasis on next generation sequencing. The final presentation will provide an overview of the changes (to be expected) in the second edition of Bethesda System for Reporting Thyroid Cytology. Upon completion of this educational activity, participants should be able to: Describe key diagnostic features of thyroid FNA specimens classified as suspicious and malignant including diagnostic pitfalls Identify the role of molecular tests, especially those which employ next generation sequencing in the management of thyroid nodules Measure the impact of proposed changes in the Bethesda Thyroid FNA Classification Scheme on your practice of thyroid FNA cytology 7:00 PM INTRODUCTION OF PROGRAM AND SPEAKERS Zubair Baloch, MD, PhD, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 7:05 PM PSC AWARDS PRESENTATION Tarik M. Elsheikh, MD, Cleveland Clinic, Cleveland, OH 7:20 PM CYTOMORPHOLOGIC THRESHOLDS FOR CLASSIFYING THYROID FNA SPECIMENS AS SUSPICIOUS AND POSITIVE FOR PAPILLARY THYROID CARCINOMA Tarik M. Elsheikh, MD, Cleveland Clinic, Cleveland, OH 7:40 PM UNDERSTANDING THE CURRENT ATA GUIDELINES FOR THYROID NODULE MANAGEMENT AND THEIR IMPACT ON THE BETHESDA SYSTEM FOR REPORTING THYROID CYTOLOGY (TBSRTC) Jeffrey F. Krane, MD, PhD, Brigham & Women s Hospital, Boston, MA 8:00 PM NEXT GENERATION SEQUENCING AND THYROID FNA; UTILITY, IMPLEMENTATION AND PITFALLS Marina N. Nikiforova, MD, FCAP, University of Pittsburgh Medical Center, Pittsburgh, PA 8:20 PM PROPOSED MODIFICATIONS AND UPDATES FOR THE THYROID BETHESDA SYSTEM FOR REPORTING THYROID CYTOLOGY FROM AN INTERNATIONAL PANEL William C. Faquin, MD, PhD, Massachusetts General Hospital, Boston, MA 8:40 PM WHAT TO EXPECT FROM THE NEW EDITION OF THYROID BETHESDA SYSTEM FOR REPORTING THYROID FNA SPECIMENS Syed Z. Ali, MD, Johns Hopkins School of Medicine, Baltimore, MD 44

75 COMPANION MEETINGS COMPANION SOCIETY MEETING PULMONARY PATHOLOGY SOCIETY Challenges in Pulmonary Pathology SATURDAY, MARCH 4, :00 PM 10:00 PM CC 225 MODERATORS: Ross Miller, MD, Houston Methodist Hospital, Houston, TX Timothy Craig Allen, MD, JD, University of Texas Medical Branch, Galveston, TX COURSE DESCRIPTION: The intent of this course is to summarize the importance and utility of endobronchial ultrasound guided fine needle aspiration (EBUS FNA). Rapid onset evaluation (ROSE) will be addressed, particularly the advantages and potential challenges associated with its implementation and use. Upon completion of this educational activity, participants should be able to: Identify the various serosal spindle cell lesions one may encounter in biopsy specimens Describe the common pre-analytic variables encountered with lung cancer cytology specimens Describe the benefits of, and challenges encountered with, endobronchial ultrasound-guided fine needle aspiration specimens 7:00 PM BIOPSY INTERPRETATION OF SPINDLE CELL PROLIFERATIONS IN THE SEROSA Richard Attanoos, MD, University Hospital Llandough, Cardiff, UK and Vale University Health 7:30 PM DIFFERENTIAL DIAGNOSIS OF NEUROENDOCRINE CARCINOMAS OF THE LUNG Alain Borczuk, MD, Weill Cornell University Medical Center, New York, NY 8:00 PM OVERVIEW OF ENDOBRONCHIAL ULTRASOUND GUIDED FINE NEEDLE ASPIRATION (EBUS FNA): BENEFITS AND CHALLENGES Ross Miller, MD, Houston Methodist Hospital, Houston, TX 8:30 PM GRANULOMATOUS LUNG DISEASE: HOW PATHOLOGIC FINDINGS ADD VALUE TO CLINICAL AND RADIOLOGIC INFORMATION Sanjay Mukhopadhyay, MD, Cleveland Clinic, Cleveland, OH 9:00 PM DIFFERENTIAL DIAGNOSIS OF LYMPHOID INFILTRATES OF THE LUNG Kirtee Raparia, MD, Northwestern University, Chicago, IL 9:30 PM PREANALYTIC VARIABLES IN CYTOLOGY: LESSONS LEARNED FROM NEXT GENERATION SEQUENCING Sinchita Roy-Chowdhuri, MD, MD Anderson Cancer Center, Houston, TX 45

76 COMPANION MEETINGS COMPANION SOCIETY MEETING INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY Update on TNM Staging of Genitourinary Cancers SATURDAY, MARCH 4, :00 PM 10:00 PM CC HEMISFAIR 1 MODERATORS: Michelle S. Hirsch, MD, PhD, Brigham and Women s Hospital, Boston, MA Steven Shen, MD, PhD, Houston Methodist Hospital, Houston, TX COURSE DESCRIPTION: In early 2017 the updated 8th edition of the AJCC Staging Classification will be released. As there have been some changes to staging of genitourinary (GU) cancers, this is a timely and important topic. The session will begin with a brief overview by Dr. Mahul Amin, the Chief Editor of the upcoming AJCC manual, followed by a summary of any changes, guidelines and/or controversies regarding the TNM staging in each of the GU related organs. Upon completion of this educational activity, participants should be able to: Describe the process of cancer TNM staging in GU organs based on recent updates to the AJCC Staging Manual Identify differences in contemporary TNM staging parameters compared to the prior 7th AJCC edition for GU cancer Understand prognostic rational behind changes made to the TNM staging system for GU cancers 7:00 PM INTRODUCTION AND PRESIDENT S REMARKS Lars Egevad, MD, PhD, Karolinska Institutet, Stockholm, Sweden 7:15 PM OVERVIEW AND PRINCIPLES FOR CONTEMPORARY AJCC TNM STAGING Mahul Amin, MD, University of Tennessee Health Science Center, Memphis, TN 7:30 PM UPDATES IN THE NEW AJCC TNM STAGING OF BLADDER CANCER: ISSUES PERTAINING TO APPLICATION IN ROUTINE SURGICAL PATHOLOGY Gladell Paner, MD, (BS)MT, University of Chicago, Chicago, IL 8:00 PM UPDATE IN TNM STAGING AND HANDLING OF KIDNEY CANCER Kiril Trpkov, MD, University of Calgary, Alberta, Canada 8:30 PM UPDATES IN TNM STAGING OF PROSTATE CANCER Sampson Fine, MD, Memorial Sloan Kettering Cancer Center, New York, NY 9:00 PM UPDATES IN TNM STAGING OF TESTICULAR CANCER Muhammad Idrees, MBBS, Indiana University, Indianapolis, IN 9:30 PM UPDATES IN TNM STAGING OF PENILE CANCER Pheroze Tamboli, MBBS, The University of Texas MD Anderson Cancer Center, Houston, TX 46

77 COMPANION MEETINGS COMPANION SOCIETY MEETING ARTHUR PURDY STOUT SOCIETY OF SURGICAL PATHOLOGISTS There Are No Magic Bullets: When Immunostains Can Get You Into Trouble SUNDAY, MARCH 5, :30 AM 12:00 PM CC HEMISFAIR 2 & 3 MODERATORS: Vania Nosé, MD, PhD, Massachusetts General Hospital, Harvard Medical School, Boston, MA Rhonda Yantiss, MD, PhD, Weill Cornell Medicine, New York, NY COURSE DESCRIPTION: Pathologists increasingly rely upon ancillary techniques, particularly immunohistochemistry, to facilitate or render diagnoses. While these stains work well in narrowing down a differential diagnosis, results can also generate confusion, particularly when pathologists utilize reflexive immunohistochemical stain panels for the evaluation of specific tumor types. Many tumors show aberrant, or unexpected expression of markers that can lead to erroneous diagnoses. For example, CD138 is generally considered to be a marker of plasma cell differentiation, although this antibody can also stain a variety of other types of plasmacytoid tumor, including gastrointestinal stromal tumors. Pleomorphic sarcomas that show epithelioid morphology often express keratins, and some lymphomas can be negative for CD45. The purpose of this session is to discuss common immunohistochemical pitfalls that can lead to diagnostic errors. Upon completion of this educational activity, participants should be able to: Describe a rationale for ordering immunohistochemical stains for the classification of soft tissue tumors Identify diagnostic problems introduced by immunohistochemical staining patterns that are not entirely specific Measure overall stain utilization in their own practices 8:30 AM INTRODUCTION Vania Nosé, MD, PhD, Massachusetts General Hospital, Boston, MA Rhonda Yantiss, MD, PhD, Weill Cornell Medical College, New York, NY 8:35 AM PRESIDENT S AWARD 8:45 AM GENITOURINARY PATHOLOGY Jesse McKenney, MD, Cleveland Clinic, Cleveland, OH 9:10 AM GASTROINTESTINAL PATHOLOGY John Hart, MD, University of Chicago, Chicago, IL 9:35 AM HEMATOPATHOLOGY Judith Ferry, MD, Massachusetts General Hospital, Boston, MA 10:00 AM BREAK 10:30 AM PRIZE 10:40 AM GYNECOLOGIC PATHOLOGY Teri Longacre, MD, Stanford University, Stanford, CA 11:05 AM SOFT TISSUE PATHOLOGY Andrew Folpe, MD, Mayo Clinic, Rochester, MN 11:30 AM NEUROENDOCRINE TUMORS David Klimstra, MD, Memorial Sloan-Kettering Cancer Center, New York, NY 47

78 COMPANION MEETINGS COMPANION SOCIETY MEETING SOCIETY FOR CARDIOVASCULAR PATHOLOGY WITH BINFORD - DAMMIN SOCIETY OF INFECTIOUS DISEASE PATHOLOGISTS Cardiovascular Infections: Contemporary Approaches to Recognition and Diagnosis SUNDAY, MARCH 5, :30 AM 12:00 PM CC 304 MODERATORS: Joseph J. Maleszewski, MD, FACC, FCAP, Mayo Clinic College of Medicine, Rochester, MN T.C. Wu, MD, PhD, The Johns Hopkins Hospital, Baltimore, MD COURSE DESCRIPTION: Cardiovascular infections are a significant cause of morbidity and mortality in developed countries. Epidemiologic trends continue to change owing to antibiotic therapy and the burgeoning array of new cardiovascular devices being installed in patients. This session will update the audience on the latest developments in the field including diagnostic strategies, emerging ancillary microbiologic studies, and general evaluation of cardiovascular tissues and devices. Both autopsy and surgical specimens will be discussed. The session will be capped by Dr. John T. Fallon, the 2017 recipient of the Society for Cardiovascular Pathology s Distinguished Achievement Award, speaking on the molecular landscape of myocarditis. Upon Completion of this educational activity, participants should be able to: Describe the gross and histopathologic findings associated with cardiovascular infections. Identify complications that represent acute and chronic sequelae of cardiovascular infections. Measure the degree to which ancillary techniques inform contemporary diagnosis of cardiovascular infections. 8:30 AM COMPLICATIONS OF NATIVE VALVE ENDOCARDITIS Mathieu Castonguay, MD, Dalhousie University, Halifax, NS 9:00 AM THE PATHOLOGISTS TOOLKIT FOR EVALUATING CASES OF INFECTIVE ENDOCARDITIS: HISTOPATHOLOGY, SPECIAL STAINS, AND MOLECULAR TECHNIQUES Bobbi S. Pritt, MD, Mayo Clinic College of Medicine, Rochester, MN 9:30 AM PARASITIC INFECTIONS OF THE HEART Danny A. Milner, MD, MSc, American Society for Clinical Pathology, Chicago, IL 10:00 AM BREAK 10:30 AM CARDIOVASCULAR DEVICE INFECTION AND THE ROLE OF BIOFILM Robert F. Padera Jr., MD, PhD, Brigham and Women s Hospital, Boston, MA 11:00 AM MYOCARDITIS: INFECTION OR AUTOIMMUNE REACTION? DEEP SEQUENCING ANALYSES John Fallon, MD, PhD, Westchester Medical Center, Valhalla, NY 11:40 AM QUESTIONS 48

79 COMPANION MEETINGS COMPANION SOCIETY MEETING COLLEGE OF AMERICAN PATHOLOGISTS Mission Control-The Value of Cancer Protocols, Staging Manuals, and the Key Revisions to Select Tumor Sites SUNDAY, MARCH 5, :30 AM 12:00 PM CC HEMISFAIR 1 MODERATORS: Joseph D. Khoury, MD, University of Texas MD Anderson Cancer Center, Houston, TX Larissa V. Furtado, MD, FCAP, University of Utah/ARUP Laboratories, Salt Lake City, UT COURSE DESCRIPTION: Since 1986, the CAP Cancer Protocols have served as a resource and reference for complete reporting of malignant tumors, including American Joint Committee on Cancer (AJCC) staging and the World Health Organization (WHO) histologic type standard elements. The CAP Cancer Committee is responsible for producing and maintaining these important reference resources and cancer reporting tools. The protocols have grown in number and scope over the past several years, and have influenced important global efforts such as the International Collaboration on Cancer Reporting (ICCR) datasets. Reporting cancer elements has progressed from the traditional narrative reporting style with observed characteristics of the neoplastic cells to more highly arranged synoptic reports that better optimize readability with computer reporting systems. The current drive to develop structured reporting for cancer attempts to organize the data elements in the synoptic field to integrate with the laboratory information system (LIS) and then with the electronic medical record (EMR). The CAP Cancer Protocols are intended to: 1) support pathologists in generating complete reports that contain all the core data elements, and 2) ensure that the core data elements are clear and unambiguous for clinicians. The CAP Cancer Protocols are evolving to meet the needs for greater data usage and integration as the cancer community develops new therapies and big-data research. Upon completion of this educational activity, participants should be able to: Explain the value of the cancer protocols to patient care Distinguish the difference between synoptic reporting and structured reporting and the value both bring to cancer patients Demonstrate the key changes to the staging elements with the AJCC 8th edition Cancer Staging Manual (TNM) 8:30 AM INTRODUCTION Joseph D. Khoury, MD, University of Texas MD Anderson Cancer Center, Houston, TX Larissa V. Furtado, MD, FCAP, University of Utah/ARUP Laboratories, Salt Lake City, UT 8:35 AM WHY CANCER PROTOCOLS? Thomas P. Baker, MD, The Joint Pathology Center, Silver Spring, MD 9:00 AM COMMON CHANGES IN TNM STAGING Thomas P. Baker, MD, The Joint Pathology Center, Silver Spring, MD 9:25 AM PATHOLOGIC STAGING UPDATES IN BREAST CANCER Patrick L. Fitzgibbons, MD, St. Jude Medical Center, Fullerton, CA 9:55 AM BREAK 10:25 AM PATHOLOGIC STAGING UPDATES IN UROLOGIC CANCERS, INCLUDING PROSTATE, BLADDER, KIDNEY AND TESTIS Ming Zhou, MD, PhD, University of Texas Southwestern Medical Center, Dallas, TX 10:55 AM PATHOLOGIC STAGING UPDATES IN COLORECTAL CANCER Sanjay Kakar, MD, University of California San Francisco, San Francisco, CA 11:25 AM PATHOLOGIC STAGING UPDATES IN LUNG CANCER Sanja Dacic, MD, PhD, University of Pittsburgh Health System, Pittsburgh, PA 11:55 AM CONCLUDING REMARKS 49

80 COMPANION MEETINGS COMPANION SOCIETY MEETING HANS POPPER HEPATOPATHOLOGY SOCIETY Major Challenges in Liver Pathology SUNDAY, MARCH 5, :30 AM 12:00 PM CC 225 MODERATOR: Michael Torbenson, MD, Mayo Clinic, Rochester, MN COURSE DESCRIPTION: The mission of the Hans Popper Hepatopathology Society is to increase knowledge about the normal and diseased liver, with a special emphasis on the role of hepatopathology in clinical care. This session focuses on 6 big problematic areas in liver pathology. In fact, these problem areas represent some of the most common reasons for submitting cases for liver pathology consultation. Upon completion of this educational activity, participants should be able to: Describe the histological features of emerging hepatic viruses; the best approach to classifying metastatic tumors; the key histological findings of noncirrhotic portal hypertension Identify the histological findings used to diagnose and classify lymphomas of the liver; histological and clinical clues to possible etiologies in cryptogenic cirrhosis; key histological findings that distinguish steatosis from steatohepatitis 8:30 AM CRYPTOGENIC CIRRHOSIS: AN APPROACH TO THE DIAGNOSIS IN THE ERA OF MOLECULAR PATHOLOGY Dhanpat Jain, MD, Yale University School of Medicine, New Haven, CT 9:00 AM BEYOND A, B AND C: OTHER INFECTIONS OF THE LIVER Venancio Alves, University of Sao Paulo School of Medicine, Sao Paulo, Brazil 9:30 AM METASTATIC DISEASE OF THE LIVER: A COMMON SENSE APPROACH TO A COMMON PROBLEM Larry Burgart, MD, University of Minnesota College of Medicine, Abbott NW Hospital Minneapolis, MN 10:00 AM HEPATIC LYMPHOMA DIAGNOSIS, AN ALGORITHMIC APPROACH Ryan M. Gill, MD, PhD, University of California San Francisco, San Francisco, CA 10:30 AM BREAK 11:00 AM IDIOPATHIC NONCIRRHOTIC PORTAL HYPERTENSION Isabel Fiel, MD, Icahn School of Medicine at Mount Sinai, New York, NY 11:30 AM STEATOSIS VERSUS STEATOHEPATITIS: SOME CLARITY ON CONTROVERSIES David Kleiner, MD, PhD, National Cancer Institute, Bethesda, MD 50

81 COMPANION MEETINGS COMPANION SOCIETY MEETING RENAL PATHOLOGY SOCIETY Update on Hereditary Nephropathies SUNDAY, MARCH 5, :30 AM 12:00 PM CC 303 AB MODERATORS: Mariam P. Alexander, MD, Mayo Clinic, Rochester, MN Leal C. Herlitz, MD, Cleveland Clinic, Cleveland, OH COURSE DESCRIPTION: The 2017 Renal Pathology Society Companion meeting will focus on providing updated, clinically relevant information on the hereditary nephropathies that are encountered by practicing renal pathologists. Specific areas of focus will include APOL1 nephropathy, Hereditary nephropathy with FSGS, Nephronophthisis/Medullary cystic kidney disease and potential therapeutic targets in Alport syndrome. Upon completion of this educational activity, participants should be able to: Describe the morphologic characteristics of different hereditary nephropathies Identify the risk factors, clinicopathologic characteristics and pathophysiology of hereditary nephropathies Measure therapeutic targets in Alport Syndrome 8:30 AM APOL1 NEPHROPATHY Jeffrey B. Kopp, MD, National Institutes of Health, Bethesda, MD 9:15 AM HEREDITARY NEPHROPATHY WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS(FSGS) Joseph P. Gaut, MD, PhD, Washington University School of Medicine, Saint Louis, MO 10:00 AM BREAK 10:30 AM NEPHRONOPHTHISIS MEDULLARY CYSTIC KIDNEY DISEASE Stephen Bonsib, MD, MS, NephroPath/Arkana Laboratories, Little Rock, AR 11:15 AM THERAPEUTIC TARGETS IN ALPORT SYNDROME Jeffrey H. Miner, PhD, Washington University School of Medicine, Saint Louis, MO 51

82 COMPANION MEETINGS COMPANION SOCIETY MEETING SOCIETY FOR ULTRASTRUCTURAL PATHOLOGY Multidisciplinary Approach to the Contemporary Diagnosis of Spindle and Epithelioid Soft Tissue Tumors SUNDAY, MARCH 5, :30 AM 12:00 PM CC 303 C MODERATORS: Guillermo A. Herrera, MD, Louisiana State University Health Sciences, Shreveport, LA Giovanna Crisi, MD, PhD, Baystate Health, Springfield, MA COURSE DESCRIPTION: The symposium will provide an overview and highlight recent developments in the diagnosis of spindle and epithelioid soft tissue tumors using a multidisciplinary approach. The first half of the symposium will cover characteristic histomorphological features, will present established and new more specific immunohistochemical markers, and will present the current molecular cytogenetics of these tumors. The second half of the symposium will focus on the application and value of ultrastructural pathology as a diagnostic and complementary tool to the workup of spindle and epithelioid soft tissue tumors, and pediatric spindle cell, fibroblastic and myofibroblastic tumors. In the current practice of surgical pathology, the small tissue sample received for diagnostic workup may be insufficient for all modalities. Ultrastructural analysis should be viewed as an important tool to narrow a differential diagnosis. The surgical pathologist should be aware of look-alikes and pitfalls in ultrastructural pathology of spindle and epithelioid tumors. Upon completion of this educational activity, participants should be able to: Describe the differential diagnosis of spindle and epithelioid soft tissue tumors, and provide an overview of the multidisciplinary approach to render a final diagnosis Identify more specific antibodies that define the line of differentiation of a tumor, its ultrastructural features, and molecular cytogenetic alterations Measure the value of the different diagnostic approaches in establishing a final diagnosis in spindle and epithelioid soft tissue tumors 8:30 AM AN UPDATE ON THE ROLE OF IMMUNOHISTOCHEMISTRY AND MOLECULAR DIAGNOSTICS IN THE EVALUATION OF SPINDLE CELL TUMORS OF SOFT TISSUE Leona A. Doyle, MD, Brigham and Women s Hospital, Boston, MA 9:15 AM DIFFERENTIAL DIAGNOSIS OF EPITHELIOID CELL TUMORS: THE ROLE OF IMMUNOHISTOCHEMISTRY AND MOLECULAR GENETICS Andrew L. Folpe, MD, Mayo Clinic, Rochester, MN 10:00 AM BREAK 10:30 AM VALUE OF ELECTRON MICROSCOPY IN THE DIFFERENTIAL DIAGNOSIS OF SPINDLE AND EPITHELIOID CELL TUMORS G. Petur Nielson, MD, Massachusetts General Hospital, Boston, MA 11:00 AM LOOK-ALIKES IN SPINDLE AND EPITHELIOID TUMORS: ULTRASTRUCTURAL VALUE AND PITFALLS IN DIAGNOSIS Guillermo A. Herrera, MD, Louisiana State University Health Sciences, Shreveport, LA 11:30 AM PEDIATRIC SPINDLE CELL, FIBROBLASTIC AND MYOFIBROBLASTIC TUMORS John Hicks, MD, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 52

83 COMPANION MEETINGS COMPANION SOCIETY MEETING AMERICAN ASSOCIATION OF OCULAR ONCOLOGISTS AND PATHOLOGISTS Biomarkers in Ocular Oncology SUNDAY, MARCH 5, :30 PM 5:00 PM CC 303 AB MODERATOR: Patricia Chevez-Barrios, MD, The Houston Methodist Hospital, Houston, TX COURSE DESCRIPTION: This course is designed to provide knowledge to practicing pathologists regarding the use of biomarkers for the diagnosis, prognosis and guidance of therapy in a number of ocular neoplasms, including intraocular melanoma, sebaceous carcinoma, orbital and neural tumors. Upon completion of this educational activity, participants should be able to: Describe the relevant biomarkers in ocular oncology Identify certain diagnostic, prognostic and predictive biomarkers in ophthalmic tumors Measure diagnostic, predictive and prognostic relevant biomarkers in ophthalmic oncology 1:30 PM BIOMARKERS IN ORBITAL TUMORS Diva Regina Salomao, MD, Mayo Clinic, Rochester, MN 2:15 PM BIOMARKERS IN NEURO-OPTHALMOPATHOLOGY Fausto J. Rodriguez, MD, The Johns Hopkins Hospital, Baltimore, MD 3:00 PM BIOMARKERS IN OCULAR MELANOMA Patricia Chevez-Barrios, MD, The Houston Methodist Hospital, Houston, TX 3:45 PM BIOMARKERS IN SEBACEOUS GLAND CARCINOMAS Sander Dubovy, MD, Bascom Palmer Eye Institute, Miami, FL 4:30 PM QUESTIONS AND ANSWERS Patricia Chevez-Barrios, MD, The Houston Methodist Hospital, Houston, TX 53

84 COMPANION MEETINGS COMPANION SOCIETY MEETING AMERICAN SOCIETY FOR CLINICAL PATHOLOGY (ASCP) Innovations in Pathology Service for Low-Middle Income Countries SUNDAY, MARCH 5, :30 PM 5:00 PM CC 303 C MODERATOR: Danny A. Milner, Jr., MD, MSc, American Society for Clinical Pathology, Chicago, IL COURSE DESCRIPTION: Non-communicable diseases, NCDs, have been established as a clear threat not only to human health, but also to development and economic growth. This session will feature five global innovators working on the front lines to solve the NCD crisis in low-middle income countries. Topics to be covered include: telepathology, connecting patients to laboratories, rapid diagnostics for cancer, social media, and pathology capacity building models. Each speaker will provide a deep-dive into how technology or systematic approaches to healthcare create real world, impactful change for patients in low and middle-income countries. The session will also highlight the importance of assessment, collaboration, and sustainability in an effort to eliminate inequities in pathology service access around the world. Upon completion of this educational activity, participants should be better able to: Understand the lack of access and need for immediate solutions to non-communicable diseases in LMICs, especially Cancer Become familiar with existing novel programs using technology and/or approaches in which session attendants may be able to participate Engage in open discussion with attendants and panelists which inspires and perpetuates the conversation within the attendants own institutions going forward 1:30 PM INTRODUCTION AND OVERVIEW Danny A. Milner, Jr, MD, MSc, American Society for Clinical Pathology, Chicago, IL 1:40 PM TELEPATHOLOGY FOR RAPID TURNAROUND TIME AND MEETING PERSONNEL NEEDS E. Blair Holladay, PhD, SCT(ASCP)CM, American Society for Clinical Pathology, Chicago, IL 2:20 PM UNMANNED DRONES FOR CONNECTING COMMUNITY HEALTH WORKERS TO CENTRAL LABS Daniel Pepper, CEO at Vayu, LLC, Ypsilanti, MI 3:00 PM BREAK 3:10 PM RAPID ASSESSMENT OF BREAST CANCER FOR TREATMENT DECISIONS Jane E. Brock, MBBS, PhD, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 3:50 PM SOCIAL MEDIA IN TEACHING, CONNECTING, AND FACILITATING PATHOLOGY SERVICES Jerad M. Gardner, MD, University of Arkansas for Medical Sciences, Little Rock, AR 4:20 PM MODELS FOR PATHOLOGY LABORATORY CAPACITATION Danny A. Milner, Jr, MD, MSc, American Society for Clinical Pathology, Chicago, IL 4:50 PM PANEL WRAP-UP DISCUSSION 54

85 COMPANION MEETINGS COMPANION SOCIETY MEETING AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY The Liquid Biopsy: Future Applications for the Pathologist Buckle Up, It May Be a Bumpy Ride! SUNDAY, MARCH 5, :30 PM 5:00 PM CC 302 AB MODERATORS: Maria J. Merino, MD, National Institutes of Health, Bethesda, MD Danny A. Milner, MD, MSc, American Society for Clinical Pathology, Chicago, IL Mark E. Sobel, MD, PhD, American Society for Investigative Pathology, Bethesda, MD COURSE DESCRIPTION: The integration of anatomic, molecular, and genomic pathology into surgical pathology practice is conspicuous in oncology, where definition of molecular pathways important for specific tumors has enabled development of new biomarkers and innovative approaches to the detection of cancer and metastases. The so-called liquid biopsy includes a wide array of new technologies, including tumor-derived tumor vesicles and aptamer probes. The surgical pathologist will need to understand these new technologies and be aware of their advantages and pitfalls as they are applied into practice. Upon completion of this educational activity, participants should be able to: Describe the new technologies associated with the liquid biopsy Understand how aptamer probes can aide in the detection of circulating tumor cells Describe the role of tumor-derived exosomes 1:30 PM INTRODUCTION TO THE ASIP COMPANION MEETING Mark E. Sobel, MD, PhD, American Society for Investigative Pathology, Bethesda, MD 1:35 PM THE LIQUID BIOPSY: INTRODUCTION AND OVERVIEW Karen L. Kaul, MD, PhD, Northshore University Health System, Evanston IL 2:15 PM LIQUID BIOPSIES IN LUNG CANCER Lynette M. Sholl, MD, Brigham & Women s Hospital, Boston, MA 3:00 PM DETECTION AND ANALYSIS OF TUMOR-DERIVED EXTRACELLULAR VESICLES Jennifer Jones, MD, PhD, National Cancer Institute, Bethesda, MD 3:40 PM A NEW MOLECULAR PROBE FOR RAPID DETECTION OF CIRCULATING TUMOR CELLS IN WHOLE BLOOD Youli Zu, MD, Houston Methodist Hospital, Houston, TX 4:20 PM FINAL THOUGHTS ON THE LIQUID BIOPSY Maria J. Merino, MD, National Cancer Institute, Bethesda, MD 55

86 COMPANION MEETINGS COMPANION SOCIETY MEETING RODGER C. HAGGITT GASTROINTESTINAL PATHOLOGY SOCIETY State of the Art: An Update on Major Challenges in Selected GI Malignancies SUNDAY, MARCH 5, :30 PM 5:00 PM CC HEMISFAIR 1 MODERATOR: Michael Torbenson, MD, Mayo Clinic, Rochester, MN COURSE DESCRIPTION: The mission of the Rodger C. Haggitt Gastrointestinal Pathology Society is to emphasize the importance of gastrointestinal pathology as a sophisticated and complex area of pathology. The Education Committee, in consultation with Society officers, determined the title, contents, and speakers of this companion meeting. The chosen topics address new advances in our understanding of the classification and treatment of selected gastrointestinal malignancies. The program will emphasize the role of the surgical pathologist in the proper workup and reporting of these premalignant and malignant conditions, with an emphasis on the findings of most importance to proper patient management. Upon completion of this educational activity, participants should be able to: Describe key changes in the AJCC staging system of GI malignancies; the molecular basis for immunotherapy and the role the pathologist plays in patient selection Identify the criteria used to grade and stage mucinous appendiceal neoplasms and goblet cell tumors of the appendix; the criteria used to identify and classify epithelial dysplasia in the setting of inflammatory bowel disease Measure the impact that proper tumor classification, grading, and staging plays in clinical care for selected GI malignancies 1:30 PM INTRODUCTION 1:30 PM SELECTED UPDATES ON AJCC STAGING OF GI MALIGNANCIES Sanjay Kakar, MD, University of California San Francisco School of Medicine, San Francisco, CA 2:00 PM IMMUNOTHERAPY FOR GI MALIGNANCIES Robert Anders, MD, PhD, Johns Hopkins University School of Medicine, Baltimore, MD 2:30 PM UPDATE ON THE DIAGNOSIS AND GRADING OF APPENDICEAL MUCINOUS NEOPLASMS Reetesh K. Pai, MD, University of Pittsburgh Medical Center, Pittsburgh, PA 3:00 PM BREAK 3:30 PM GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD, University of California Los Angeles, Los Angeles, CA 4:00 PM RODGER C. HAGGITT MEMORIAL LECTURE: DYSPLASIA IN INFLAMMATORY BOWEL DISEASE Robert Riddell, MBBS, Mount Sinai Hospital, Toronto, Ontario 56

87 COMPANION MEETINGS COMPANION SOCIETY MEETING INTERNATIONAL SOCIETY OF BONE AND SOFT TISSUE PATHOLOGY Tumor Syndromes in Bone and Soft Tissue Pathology SUNDAY, MARCH 5, :30 PM 5:00 PM CC 301 MODERATORS: Julia Bridge, MD, Nebraska Health System, Omaha, Nebraska Judith VMG Bovée, MD, PhD, Leiden University Medical Center, Leiden, The Netherlands COURSE DESCRIPTION: Hereditary etiologies corresponding to Mendelian inheritance principles, in addition to congenital malformation syndromes lacking a clear inheritance pattern, have increasingly been recognized as responsible for a subset of bone and soft tissue tumor diagnoses in children and adults. A continuing rise in the identification of cancer-causing germline mutations for which molecular testing is available, coupled with a heightened awareness of the importance of a detailed family history for sarcoma patients, has improved diagnosis, prevention, surveillance, and therapy for affected families. The genetic breakthroughs that have resulted from the investigation of inherited cancer syndromes have not only benefited patients with heritable tumor predisposition but have also shed light on the regulatory molecular pathways in sporadic tumors thereby advancing the care of sarcoma patients without known risk factors too. These discoveries continue to expand the role of the surgical pathologist in the multidisciplinary care of patients with these neoplasms. In this companion meeting, new developments as well as current principles of molecular and surgical pathology in bone and soft tissue tumors (heritable and sporadic counterparts) and their application to the clinical management of these neoplasms will be emphasized. The symposium theme and content are selected by the President with input from the executive officers of the International Society of Bone and Soft Tissue Pathology. The agenda has been designed to meet the educational needs of general surgical pathologists as well as bone and soft tissue tumor subspecialists who are involved in the management of patients with mesenchymal neoplasms. Upon completion of this educational activity, participants should be better able to: Recognize recent developments in genomics of sarcomas arising in hereditary and sporadic settings Describe the role of germline/somatic biomarkers in the diagnostic classification, prognostication, and/or management of sarcomas that may arise Associate clinicomorphologic variants with specific genetic changes 1:30 PM WELCOME; TUMOR SYNDROMES IN BONE AND SOFT TISSUE PATHOLOGY Judith VMG Bovée, MD, PhD, Leiden University Medical Center, Leiden, The Netherlands 1:35 PM NEUROFIBROMATOSIS TYPE 1 SYNDROME AND ASSOCIATED TUMORS Steven L. Carroll, MD, PhD, Medical University of South Carolina, Charleston, SC 2:10 PM TUMOR SYNDROMES PREDISPOSING TO OSTEOSARCOMA Meera R. Hameed, MD, Memorial Sloan-Kettering Cancer Center, New York, NY 2:35 PM GNAS RELATED MESENCHYMAL TUMORS Gene P. Siegal, MD, PhD, University of Alabama, Birmingham, AL 3:00 PM BREAK 3:30 PM METABOLIC ENZYMES (IDH, FH, SDH) AND MESENCHYMAL TUMOR (SYNDROME)S Judith VMG Bovée, MD, PhD, Leiden University Medical Center, Leiden, The Netherlands 4:05 PM FAMILIAL ADENOMATOUS POLYPOSIS AND ASSOCIATED MESENCHYMAL TUMORS Cheryl M. Coffin, MD 4:30 PM CONCLUDING REMARKS 57

88 COMPANION MEETINGS COMPANION SOCIETY MEETING NORTH AMERICAN SOCIETY OF HEAD & NECK PATHOLOGY 20th Anniversary of the NASHNP: Then and Now: Evolving Concepts in Head and Neck Pathology A Festschrift for E. Leon Barnes SUNDAY, MARCH 5, :30 PM 5:00 PM CC 304 MODERATORS: Susan Muller, DMD, MS, Atlanta Oral Pathology, Decatur, GA Leon Barnes, MD, Professor Emeritus, University of Pittsburgh, Pittsburgh, PA COURSE DESCRIPTION: A Festschrift is a German word meaning a collection of writings by different authors published in honor of a scholar usually on a special occasion. The topics were selected by E. Leon Barnes, MD to celebrate the 20th anniversary of NASHNP symposia at USCAP. Dr. Barnes was instrumental in establishing the NASHNP and was the society s first president. The selected speakers will focus on an area of head and neck pathology that was originally published by Dr. Barnes, and then will describe the advances that have occurred since the original publications. Upon completion of this educational activity, participants should be better able to: Name the three histologic subtypes of Schneiderian papillomas Understand the role of human papillomavirus in the development of the three types of Schneiderian papillomas Understand the anatomy, localization, and pathology of paragangliomas of the head and neck including their molecular aspects Review the evolving diagnostic criteria of salivary tumors Describe the diagnostic criteria for salivary duct carcinoma, its histologic variants, and the molecular aspects related to tumor growth and treatment Understand the classification of sinonasal intestinal type adenocarcinomas, their risk factors, and prognostic and molecular features 1:30 PM INTRODUCTION Susan Muller, DMD, MS, Atlanta Oral Pathology, Decatur, GA 1:40 PM OSPS AND ESPS AND ISPS, OH MY! AN UPDATE ON SCHNEIDERIAN PAPILLOMAS Justin Bishop, MD, Johns Hopkins University School of Medicine, Baltimore, MD 2:10 PM PARAGANGLIOMAS OF THE HEAD & NECK: AN OVERVIEW Michelle Williams, MD, University of Texas MD Anderson Cancer Center, Houston, TX 2:40 PM SALIVARY DUCT CARCINOMA: IT S APOCRINE NATURE, ANDROGEN RECEPTER EXPRESSION, AND DIFFERENTIAL DIAGNOSIS Simion Chiosea, MD, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA 3:10 PM BREAK 3:30 PM INTESTINAL-TYPE ADENOCARCINOMAS: CURRENT CLASSIFICATION, IMMUNOHISTOCHEMISTRY/MOLECULAR PROFILE AND DIFFERENTIAL DIAGNOSIS Ilmo Lievo, MD, University of Turku, Turku, Finland 4:00 PM FAMOUS PEOPLE WITH HEAD & NECK DISEASE Leon Barnes, MD, Professor Emeritus, University of Pittsburgh Medical Center Presbyterian Hospital, Pittsburgh, PA 58

89 COMPANION MEETINGS COMPANION SOCIETY MEETING PALEOPATHOLOGY CLUB Paleopathology Around the Globe SUNDAY, MARCH 5, :30 PM 3:00 PM CC 302 C MODERATORS: Enrique Gerszten, MD, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA Pedro L. Fernández, MD, PhD, Hospital Clinic and University of Barcelona, Barcelona, Spain COURSE DESCRIPTION: Paleopathology has a close relation with the history of medicine. This symposium focuses on the use of modern techniques available to determine the diseases of the past. The topics were suggested by members of the Paleopathology Club, and they were selected by the Chairmen of the program. This symposium has been designed for Pathologists to learn about the disease that were present in the antiquity in different areas of the globe. Upon completion of this educational activity, participants should be better able to: Describe some of the lesions that were presented Identify the geographic areas, where the pathology was found Measure the prevalence of diseases in specific locations 1:30 PM HEALTH TRENDS AMONG ROMAN PERIOD BURIALS Robert R. Paine, PhD, Texas Tech University, Lubbock, TX 2:15 PM ORAL AND DENTAL PATHOLOGY IN NATIVE AMERICANS FROM THE LATE MISSISSIPPIAN PERIOD Michelle D. Hamilton, PhD, Texas State University, San Marcos, TX 59

90 COMPANION MEETINGS COMPANION SOCIETY MEETING SOCIETY FOR HEMATOPATHOLOGY An Update on Monocytic and Histiocytic Neoplasms and Disorders SUNDAY, MARCH 5, :30 PM 5:00 PM CC HEMISFAIR 2 & 3 MODERATORS: Michele Paessler, DO, Perelman School of Medicine, Philadelphia, PA Robert Lorsbach, MD, Cincinnati Children s Hospital, Cincinnati, OH COURSE DESCRIPTION: The Society for Hematopathology Companion Meeting will focus on neoplasms and reactive disorders of monocytes, histiocytes and dendritic cells. There have been recent, significant advances in our understanding of the pathogenesis and diagnosis of these neoplasms and disorders. Topics to be covered in this session include an update on the recently revised WHO classification of the histiocytoses and neoplasms of the macrophage-dendritic cell lineage, the pathogenesis of juvenile myelomonocytic leukemia, histopathology and genetics of dendritic cell neoplasms, the plasmacytoid dendritc cell neoplasms, the genomics of Langerhans cell histiocytoses and other histiocytic neoplasms, and an update on the pathogenesis and diagnosis of hemophagocytic lymphohistiocytosis. The program includes a panel of expert speakers and will provide an excellent opportunity for participants to update their knowledge of the pathogenesis, genomics and diagnosis of this group of often challenging neoplasms and disorders. Upon completion of this educational activity, participants should be able to: Describe the recently updated WHO classification of histiocytoses, tumors of macrophage-dendritic cell lineage and juvenile myelomonocytic leukemia Understand the role of immunohistochemistry and molecular testing in the diagnosis and prognostication of the macrophage-dendritic cell neoplasms, including Langerhans cell histiocytosis Describe the pathogenesis of hemophagocytic lymphohistiocytosis (HLH), including the predisposing genetic lesions, and the current diagnostic criteria for HLH 1:30 PM UPDATES IN JMML Mignon Loh, MD, PhD, University of California San Francisco, San Francisco, CA 2:00 PM WHO HAS AN UPDATE ON THE HISTIOCYTOSIS CHECK IN YOUR BLOOD: A BRIEF UPDATE ON HISTIOCYTIC NEOPLASMS AND DISORDERS Jennifer Picarsic, MD, University of Pittsburgh School of Medicine, Pittsburgh, PA 2:30 PM PLASMACYTOID DENDRITIC CELL NEOPLASMS Fabio Facchetti, MD, PhD, University of Brescia School of Medicine, Brescia, Italy 3:00 PM BREAK 3:30 PM DENDRITIC CELL NEOPLASMS: HISTOLOGY, IMMUNOHISTOCHEMISTRY, AND MOLECULAR GENETICS Jason Hornick, MD, PhD, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 4:00 PM REBRANDING HISTIOCYTIC DISORDERS Carl Allen, MD, PhD, Baylor College of Medicine and Texas Children s Cancer Center, Houston, TX 4:30 PM HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: A UNIQUE IMMMUNOREGULATORY DISORDER Michael B. Jordan, MD, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 60

91 COMPANION MEETINGS COMPANION SOCIETY MEETING INTERNATIONAL SOCIETY OF GYNECOLOGICAL PATHOLOGISTS The International Society of Gynecological Pathologist (ISGyP) Endometrial Carcinoma Project: Areas of Controversy SUNDAY, MARCH 5, :30 PM 5:00 PM CC 225 MODERATORS: W. Glenn McCluggage, MD, FRCPath, Belfast Health and Social Care Trust, Belfast, Ireland Vinita Parkash, MBBS, Yale University School of Medicine, New Haven, CT COURSE DESCRIPTION: The of International Society of Gynecological Pathologists convened a project to recommend guidelines for standardizing the diagnosis and reporting of endometrial carcinoma in The project was undertaken because of discussions that occurred while updating the most recent edition of the WHO blue book on the Diagnosis of Gynecologic Neoplasms. Experts felt that there were significant inconsistencies in terminology and criteria for the diagnosis of endometrial carcinoma around the world. It was also felt that there was need to update the currently used criteria to include recent advances in the understanding of molecular events in endometrial carcinoma. The ISGyP sponsored a broad project which included conducting a survey of the membership of the ISGyP to identify areas of controversy and confusion in the diagnosis of endometrial carcinoma. A conference was subsequently convened in Seattle in 2016, where discussion occurred and where possible guidelines were vetted and standardized criteria proposed. This conference will discuss the culmination of those efforts and will present those guidelines and recommendations, which will be published in 2017 in the International Journal of Gynecological Pathology. Upon completion of this symposium, participants should be better able to: Define the most useful histological features and immunohistochemical stains to diagnose clear cell carcinoma of the endometrium Identify the patterns of mixed endometrial cancer and distinguish them from diagnostic mimics Describe strategies for classifying high grade endometrial carcinoma into clinically relevant categories Determine how to assess staging parameters in endometrial carcinoma Describe the standardized grossing of tissues removed for the diagnosis and staging of endometrial carcinoma Describe the recent developments in the molecular classification of endometrial carcinoma 1:30 PM RATIONALE AND BACKGROUND FOR THE ISGYP ENDOMETRIAL CARCINOMA PROJECT Vinita Parkash, MBBS, Yale University School of Medicine, New Haven, CT 1:40 PM THE DIAGNOSIS OF MIXED CARCINOMA OF THE ENDOMETRIUM Joseph Rabban, MD, MPH, University of California San Francisco, San Francisco, CA 2:05 PM STRATEGIES FOR CLASSIFYING ENDOMETRIAL CARCINOMA WITH CLEAR CELLS Oluwole Fadare, MD, University of California San Diego, San Diego, CA 2:35 PM STRATEGIES FOR TYPING HIGH GRADE ENDOMETRIAL CARCINOMA Blake Gilks, MD, Vancouver General Hospital, Vancouver, BC 3:05 PM BREAK 3:30 PM ISGYP AWARD CEREMONY W. Glenn McCluggage, FRCPath, Belfast Health and Social Care Trust, Belfast, Ireland 3:35 PM SELECTED AREAS OF DIFFICULTY IN THE STAGING OF ENDOMETRIAL CARCINOMA W. Glenn McCluggage, FRCPath, Belfast Health and Social Care Trust, Belfast, Ireland 4:05 PM OPTIMAL GROSSING PARAMETERS IN THE REPORTING OF ENDOMETRIAL CANCERS Anais Malpica, MD, MD Anderson Cancer Center, Houston, TX 4:30 PM AUDIENCE Q & A AND COMMENTS 61

92 COMPANION MEETINGS COMPANION SOCIETY MEETING HISTORY OF PATHOLOGY SOCIETY Pathology in the Wake of the Great War SUNDAY, MARCH 5, :30 PM 5:00 PM CC 302 C MODERATOR: James R. Wright, Jr., MD, PhD, University of Calgary, Calgary, AB, Canada COURSE DESCRIPTION: This is the centenary of World War I, an event that changed the world and had a profound impact on the practice of pathology. No previous sessions have specifically addressed the practice of pathology and laboratory medicine during and immediately after the War nor have there been any presentations describing medical museum specimens collected during the War and their use and fate after the War. This session will fulfill these unmet needs. Upon Completion of this educational activity, participants should be able to: Describe the nature of laboratory services provided to the American Expeditionary Forces during WWI Describe how pathology/laboratory medicine became a hospital-based clinical specialty in the wake of the WWI Describe pathological specimens collected by the participants in WWI and their use and fate thereafter 3:30 PM HOW PATHOLOGY BECAME A CLINICAL DISCIPLINE IN AMERICA James R. Wright, MD, PhD, University of Calgary and Calgary Laboratory Services, Calgary, AB 4:30 PM A COOKE'S TOUR TO FIND THE REMAINING PATHOLOGY SPECIMENS COLLECTED DURING WW1 BY THE PATHOLOGISTS IN THE VARIOUS COMBATANT COUNTRIES Robin Cooke, MD, Royal Brisbane Hospital, Brisbane, Australia 62

93 COMPANION MEETINGS COMPANION SOCIETY MEETING INTERNATIONAL SOCIETY OF BREAST PATHOLOGY Molecular Diagnostics in Breast Pathology SUNDAY, MARCH 5, :30 PM 10:30 PM CC 225 MODERATORS: K.P. Siziopikou, MD, PhD, Northwestern University Feinberg School of Medicine, Chicago, IL Gelareh Farshid, MD, The University of Adelaide, South Australia COURSE DESCRIPTION: The purpose of the companion meeting is to inform the audience regarding the most recent changes in the practice of breast pathology. The current program will cover the emerging use of molecular diagnostics in breast pathology. The clinical applications of this state-of-art testing as well as future directions will be discussed. Upon Completion of this educational activity, participants should be able to: Describe how state-of-art molecular analysis contributes to proper diagnosis and management of carcinomas of the breast Identify the available and emerging molecular diagnostic tests in breast cancer Understand the increasing importance of genomics in the pathologic assessment of carcinomas of the breast 7:00 PM BUSINESS MEETING 7:15 PM INTRODUCTION AND PRESIDENT S REMARKS Ira Bleiweiss, MD, Hospital of the University of Pennsylvania, Philadelphia, PA 7:20 PM PRESENTATION OF TRAINEE AWARDS Ira Bleiweiss, MD, Hospital of the University of Pennsylvania, Philadelphia, PA 7:30 PM GENOMIC TOOLS IN BREAST CANCER; THE BREAST ONCOLOGIST S PERSPECTIVE Virginia G. Kaklamani, MD, University of Texas Health Science Center, San Antonio, TX 8:00 PM IMMUNE TARGETING IN BREAST CANCER Ashley Cimino-Mathews, MD, The Johns Hopkins Hospital, Baltimore, MD 8:30 PM CIRCULATING DNA AND NGS TECHNOLOGY Jorge S. Reis-Filho, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY 9:00 PM BREAST PATHOLOGY: WHAT IS TRENDING NOW Ira Bleiweiss, MD, Hospital of the University of Pennsylvania, Philadelphia, PA Edi Brogi, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY 9:30 PM QUESTIONS & ANSWERS 63

94 COMPANION MEETINGS COMPANION SOCIETY MEETING AMERICAN SOCIETY OF CYTOPATHOLOGY New Frontiers in Cytopathology Practice SUNDAY, MARCH 5, :30 PM 10:30 PM CC 301 MODERATOR: Rana Hoda, MD, FIAC, New York Presbyterian Hospital, New York, NY COURSE DESCRIPTION: The new frontiers in cytopathology will be addressed. (1) Application of cytological techniques in circulating tumor cell specimens: The circulating tumor cell (CTC) field is rapidly advancing with the advent of continuously improving technologies for enriching these rare neoplastic cells from blood. CTC has the potential to provide useful information for the clinical decision-making process in this era of personalized medicine and targeted therapeutics. CTC samples can be processed in the cytology laboratory with routine methods. (2) Primary HPV testing in cervical cancer screening: In April of 2014, the FDA approved the use of an HPV test (the cobas HPV test) for primary cervical cancer screening for women over the age of 25 years, without the need for a concomitant Pap test. This session will discuss the pros and cons for primary HPV test; (3) Advances in Pancreaticobiliary Cytology: Recent advances in pancreaticobiliary cytology with integrated cytology reporting, use of standardized terminology, new biopsy techniques and molecular testing of pancreatic cyst fluid will be also presented; (4) Ancillary Molecular Testing in Indeterminate Thyroid Nodules: How far have we come? This presentation will provide an overview of types of molecular tests available and the effect of these tests on rate of malignancy and management of indeterminate nodules. (5) Morphology and Molecular Testing in Non-Small Cell Carcinoma of the Lung (NSCLC): This presentation will summarize recent guidelines of the International Association for the Study of Lung Cancer, World Health Organization and Papanicolaou Society of Cytopathology, advances in NSCLC treatment including molecular targeted therapy and immunotherapy and its impact on the practice of cytopathologists. Upon completion of this educational activity, participants should be better able to: Describe advances and new frontiers in cytopathology practice Understand how to integrate clinical information and ancillary testing of lung, pancreatobiliary and thyroid lesions into cytology report Become familiar with new role of HPV test and circulating tumor cells in cytopathology practice 7:30 PM WELCOME AND INTRODUCTION Rana Hoda, MD, FIAC, New York Presbyterian Hospital, New York, NY 7:40 PM APPLICATION OF CYTOLOGICAL TECHNIQUES IN CIRCULATING TUMOR CELL SPECIMENS Alarice Lowe, MD, Brigham and Women s Hospital, Boston, MA 8:05 PM PRIMARY HPV TESTING IN CERVICAL CANCER SCREENING Jason Stone, MD, QML Pathology, Brisbane, Australia 8:30 PM ADVANCES IN PANCREATICOBILIARY CYTOLOGY Martha B. Pitman, MD, Massachusetts General Hospital, Boston, MA 8:55 PM ANCILLARY MOLECULAR TESTING IN INDETERMINATE THYROID NODULES: HOW FAR HAVE WE COME? William C. Faquin, MD, PhD, Massachusetts General Hospital, Boston, MA 9:25 PM MORPHOLOGY AND MOLECULAR TESTING IN NON-SMALL CELL CARCINOMA OF LUNG William Travis, MD, Memorial Sloan Kettering Cancer Center, New York, NY 64

95 COMPANION MEETINGS COMPANION SOCIETY MEETING AMERICAN SOCIETY OF DERMATOPATHOLOGY What's New in Dermatopathology - An Update SUNDAY, MARCH 5, :30 PM 10:30 PM CC 302 AB MODERATOR: Meera Mahalingam, MD, PhD, FRCPath, VA Integrated Services Network (VISN1), New England, West Roxbury, MA COURSE DESCRIPTION: The purpose of this topic is to underscore updates in select topics in dermatopathology. Topics covered will include Melanocytic proliferations, Immunohistochemistry, Adnexal neoplasms, Lymphoproliferative Disorders and Inflammatory Dermatoses. The format followed will be to describe cases that are illustrative of emerging entities/novel methodologies pertinent to the topic assigned. The relevance of clinicopathologic correlation as well as teaching points/take home messages will be emphasized. Upon completion of this educational activity, participants should be able to: Describe emerging entities in dermatopathology Identify new tools of utility in dermatopathology as diagnostic adjuncts Measure the relevance of the above in everyday practice 7:30 PM INTRODUCTION Meera Mahalingam, MBBS, PhD, FRCPath, VA Integrated Services Network (VISN1), New England, West Roxbury, MA 7:35 PM MELANOCYTIC PROLIFERATIONS Aleodor A. Andea, MD, MBA, University of Michigan Health System, Ann Arbor, MI 8:05 PM IMMUNOHISTOCHEMISTRY Drazen M. Jukic, MD, PhD, Georgia Dermatology and Skin Cancer Center and Georgia Dermatopathology, Savannah, GA 8:35 PM ADNEXAL NEOPLASMS Meera Mahalingam, MBBS, PhD, FRCPath, VA Integrated Services Network (VISN1), New England, West Roxbury, MA 9:00 PM LYMPHOPROLIFERATIVE DISORDERS Uma Sundram, MD, Beaumont Hospital Health-Anatomic Pathology, Royal Oak, MI 9:35 PM INFLAMMATORY DERMATOSES Claudia I. Vidal, MD, St Louis University, School of Medicine, St. Louis, MO 65

96 COMPANION MEETINGS COMPANION SOCIETY MEETING ASSOCIATION FOR MOLECULAR PATHOLOGY Lessons Learned in Molecular Oncology SUNDAY, MARCH 5, :30 PM 10:30 PM CC 304 MODERATORS: Cecilia Yeung, MD, Fred Hutchinson Cancer Research Center, Seattle WA James R. Cook, MD, PhD, Cleveland Clinic and Case Western Reserve University Cleveland, OH COURSE DESCRIPTION: Molecular diagnostic assays play an increasingly important role in the diagnosis, classification, and prognostic assessment of cancer, as well as in guiding the selection of treatment modalities. Keeping up with the rapid pace of new discoveries in molecular oncology creates numerous practical challenges for surgical pathologists and molecular diagnostic laboratories alike. In this session, speakers will address the current standard of molecular diagnostic practice in selected aspects of hematolymphoid, pulmonary, and gastrointestinal pathology. Speakers will be selected to represent knowledgeable individuals in these fields, and to provide a cross-section of perspectives including academic molecular pathology laboratories, reference laboratories, and the surgical pathologists and hematopathologists who must integrate results of molecular diagnostic assays into their final pathology reports. Each speaker will be asked to address a specific challenge faced in their practice, and the steps they took to address these challenges. Possible examples include: the choice of analytes to be tested; selection of appropriate methodologies; integration of multiple modalities, such as sequencing, FISH, and arrays; balancing standard of care and research needs; expanding informatics infrastructure; appropriate formatting of reports and integration with surgical pathology results; hurdles to billing and reimbursement. Upon completion of this educational activity, participants should be better able to: Describe current standards of molecular diagnostic practice in lung, gastrointestinal, and hematolymphoid cancers Identify appropriate molecular diagnostic methodologies and challenges in the health system environment Measure differences in clinical practice based on molecular diagnostic reporting and interpretation 7:30 PM WELCOME AND INTRODUCTION James R. Cook, MD, PhD, Cleveland Clinic, and Case Western Reserve University, Cleveland, OH 7:45 PM MOLECULAR STUDIES IN LUNG CANCER Neal I. Lindeman, MD, Brigham & Women s Hospital, Harvard Medical school, Boston, MA 8:15 PM MOLECULAR STUDIES IN GI PATHOLOGY Antonia R. Sepulveda, MD, PhD, Columbia University Medical Center, New York, NY 8:45 PM MOLECULAR STUDIES IN MYELOID NEOPLASMS Todd W. Kelley, MD, University of Utah and ARUP Laboratories, Salt Lake City, UT 9:15 PM FUTURE DIRECTIONS AND PANEL Q & A Cecilia C.S. Yeung, MD, Fred Hutchinson Cancer Research Center, Seattle, WA 66

97 SPECIALTY CONFERENCES #IAMUSCAP #USCAP2017

98 PATHOLOGY AT THE SPEED OF THOUGHT THE POWERS-SANCHEZ INTERACTIVE CENTER The Powers-Sanchez Interactive Center is designed for collaborative meetings to update classification/guidelines, teach molecular sciences, and project clinical impact. THE INTERACTIVE CENTER FEATURES: Two laboratories, each with an 18-head teaching microscope and 17 individual personal use microscopes Year-round, courses in all subspecialties of anatomic pathology that incorporate clinical correlation, ancillary studies, molecular pathology and genomics High definition cameras and telepathology software Digital displays of radiographic and gross images to enhance the microscopic reviews Ultrasound equipment for teaching interventional fine needle aspiration biopsy The sessions are intended to refine pathologists skills as practice changers for all genres (academics, community practice, commercial laboratories) and experience levels from trainees to department chairs. For more information, visit PA L M S P R I N G S, C A THE LINDER LEARNING CENTER The Linder Learning Center, a state-of-the-art broadcast studio and conference theater opened in May 2016, unites pathologists across the globe with live courses at the Powers-Sanchez Interactive Center. This interplay with the interactive center provides visual exchanges and content capture from experts in microscopy, uniting learners at the multi-head microscopes with those in the conference theater. The broadcast studio is designed for real-time WebEx broadcasts and digital asset productions targeted to global outreach and the education of pathologists world-wide, particularly those in low-resource settings. Courses, lectures, and interactive discussion sessions in the conference theater can be directed to educational products, bringing the latest information in diagnostics and translational research to pathologists everywhere. THE STUDIO IS COMPLETE WITH: A control room Editing suite Superb image capture and transmission A dedicated demonstration laboratory that vendors can schedule to familiarize learners with their latest products

99 EVENING SPECIALTY CONFERENCES SUNDAY GENITOURINARY PATHOLOGY Difficult Diagnoses in Genitourinary Pathology SUNDAY, MARCH 5, :30 PM-9:30 PM CC HEMISFAIR 1 MODERATOR: PANELISTS: Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic and Lerner Research Institute, Cleveland, OH Priya Rao, MD, MD Anderson Cancer Center, Houston, TX Sean Williamson, MD, Henry Ford Hospital, Detroit, MI Maria Picken, MD, Loyola University Medical Center, Maywood, IL Rajal Shah, MD, Miraca Life Sciences, Irving, TX Upon completion of this activity, participants should be able to: 1. Sharpen existing expertise and enhance the participant s spectrum of professional competency 2. Familiarize with uncommon entities in genitourinary pathology 3. Recognize pitfalls and identify pearls to accurate pathologic diagnoses OPHTHALMIC PATHOLOGY Tumors of the Orbit: Recent Updates and Diagnostic Approaches SUNDAY, MARCH 5, :30 PM-9:30 PM CC 303 C MODERATOR: PANELISTS: Fausto J. Rodriguez, MD, Johns Hopkins University, Baltimore, MD Patricia Chevez-Barrios, MD, Methodist Hospital, Houston, TX Nora Laver, MD, Tufts University School of Medicine, Boston, MA Mukul Divatia, MD, Methodist Hospital, Houston, TX Anat Stemmer-Rachamimov, MD, Massachusetts General Hospital, Boston, MA Upon completion of this activity, participants should be able to: 1. Identify the spectrum of myoepithelial neoplasms developing in the lacrimal gland 2. Formulate a working differential diagnosis of nerve sheath tumors and associated syndromes affecting the orbit 3. Recognize the histopathologic features of pseudoneoplastic mass lesions that may be encountered in orbital biopsies 4. Recognize the ancillary techniques and molecular tests helpful in the characterization and prognostication of orbital tumors 67

100 EVENING SPECIALTY CONFERENCES SUNDAY PATHOLOGIST-IN-TRAINING Landing the Job of Your Dreams SUNDAY, MARCH 5, :30 PM-9:30 PM CC 221 D MODERATOR: PANELISTS: Barbara S. Ducatman, MD, West Virginia University School of Medicine, Morgantown, WV Flavia Rosado, MD, West Virginia University School of Medicine, Morgantown, WV Jeffrey Vos, MD, West Virginia University School of Medicine, Morgantown, WV Barbara Ducatman, MD, West Virginia University School of Medicine, Morgantown, WV Upon completion of this activity, participants should be able to: 1. Identify basics of the CV and describe the elements of a polished cover letter 2. Define the usual questions asked in an interview and describe successful interview strategies 3. Compare and contrast negotiation styles and strategies PEDIATRIC PATHOLOGY Hereditary Cancer Predisposition in Children SUNDAY, MARCH 5, :30 PM-9:30 PM CC 303 AB MODERATORS: PANELISTS: Kyle Kurek, MD, Alberta Children's Hospital and University of Calgary, Calgary, AB, Canada. Megan K. Dishop, MD, Children's Hospitals and Clinics of Minnesota, Minneapolis-St. Paul, MN Ashley Hill, MD, Children's National Medical Center, Washington DC Kyle Kurek, MD, Alberta Children's Hospital, University of Calgary, Calgary, Canada Alexander Judkins, MD, Children's Hospital Los Angeles, Los Angeles, CA Cristina Antonescu, MD, Memorial Sloan Kettering Cancer Center, New York, NY Upon completion of this activity, participants should be able to: 1. List the most common genes associated with hereditary cancer predisposition in infants and children 2. Recognize the association between specific rare tumor types and genetic predisposition to cancer 3. Identify patterns of hereditary cancer predisposition based on family history 4. Describe the biologic basis for oncogenesis in childhood, using an example of a tumor suppressor gene and a gene regulating microrna 5. Understand the pathologist s role in recommending additional screening for pediatric oncology patients and their families 68

101 EVENING SPECIALTY CONFERENCES MONDAY BONE AND SOFT TISSUE PATHOLOGY Diagnostic Pitfalls in Bone and Soft Tissue Pathology MONDAY, MARCH 6, :30 PM-9:30 PM CC 221 MODERATOR: PANELISTS: Jason L. Hornick, MD, PhD, Brigham and Women's Hospital, Boston, MA Elizabeth Demicco, MD, PhD, Mount Sinai, New York, NY Khin Thway, Royal Marsden Hospital, London, United Kingdom Francois Le Loarer, MD, PhD, Centre Leon Berard, Lyon, France Brendan Dickson, MD, Mount Sinai, Toronto, Ontario, Canada Michael Klein, MD, Hospital for Special Surgery, New York, NY Upon completion of this activity, participants should be able to: 1. Appreciate recent updates in the diagnosis and classification of bone and soft tissue tumors 2. Effectively use new immunohistochemical markers for differential diagnosis 3. Interpret the results of molecular genetic findings in the context of histology CYTOPATHOLOGY Unusual/Interesting Cases with a Message MONDAY, MARCH 6, :30 PM-9:30 PM CC 301 MODERATOR: PANELISTS: Dina R. Mody, MD, The Methodist Hospital, Houston, TX Paul Ohori, MD, University of Pittsburgh Medical Center-Presbyterian Hospital, Pittsburgh, PA Esther Diana Rossi, MD, The Catholic University, Rome, Italy Fadi Abdul-Karim, MD, Cleveland Clinic, Cleveland, OH Vickie Jo, MD, Brigham and Women s Hospital, Boston, MA Upon completion of this activity, participants should be able to: 1. Understand the applications of molecular testing to cytopathology specimens for accurate diagnosis 2. Be cognizant of the limitations of molecular and ancillary testing in certain conditions 3. Effectively use new reporting terminologies and guidelines as applicable to cytopathology 69

102 EVENING SPECIALTY CONFERENCES MONDAY HEMATOPATHOLOGY Hematopathology Challenges: What They Didn t Teach You in Fellowship MONDAY, MARCH 6, :30 PM-9:30 PM CC 225 MODERATORS: PANELISTS: James R. Cook, MD, PhD, Cleveland Clinic, Cleveland, OH Tracy George, MD, University of New Mexico, Albuquerque, NM Robert Ohgami, MD, PhD, Stanford University, Stanford, CA Carlos Bueso-Ramos, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX Annette Kim, MD, PhD, Brigham and Women s Hospital, Boston, MA Magdalena Czader, MD, PhD, Indiana University, Indianapolis, IN Upon completion of this activity, participants should be able to: 1. Provide a differential diagnosis of hematopathology disorders based on select clinical and pathologic findings 2. Identify the key histopathologic features associated with specific hematopathology disorders 3. Select ancillary studies that aid in determining the diagnosis for specific hematopathology disorders LIVER PATHOLOGY Secrets from the Consult Files: Puzzling Cases Solved Piece by Piece MONDAY, MARCH 6, :30 PM-9:30 PM CC 302 MODERATOR: PANELISTS: Michael Torbenson, MD, Mayo Clinic, Rochester, MN Joseph Misdraji, MD, Massachusetts General Hospital, Boston, MA Uta Drebber, University of Cologne Institute of Pathology, Köln, Germany Steve Lagana, MD, Columbia University, New York, NY Bita Naini, MD, University of California Los Angeles, Los Angeles, CA Bill Cummings, MD, University of Indiana, Bloomington, IN Upon completion of this activity, participants should be able to: 1. Integrate clinical information and laboratory testing results into their interpretation of liver biopsy injury patterns 2. Understand the differential for common and uncommon patterns of liver injury 3. Effectively use Immunohistochemical stains when evaluating liver biopsies 70

103 EVENING SPECIALTY CONFERENCES TUESDAY CARDIOVASCULAR PATHOLOGY The Cardiovascular System in Systemic Disease TUESDAY, MARCH 7, :30 PM-9:30 PM CC 301 MODERATORS: Henry Tazelaar, MD, Mayo Clinic, Scottsdale, AZ Robert Padera, MD, PhD, Brigham and Women s Hospital, Boston, MA PANELISTS: Gayle Winters, MD, Brigham & Women s Hospital, Boston, MA Brandon Larsen, MD, PhD, Mayo Clinic Arizona, Scottsdale, AZ Mike Seidman, MD, PhD, St. Paul s Hospital and University of British Columbia, Vancouver, BC, Canada Marc Halushka, MD, PhD, Johns Hopkins Medical Institutions, Baltimore, MD Upon completion of this activity, participants should be able to: 1. Have an understanding of the key pathologic features required for a diagnosis of Erdheim Chester disease 2. Know the significance of a diagnosis of anti-phospholipid antibodies and how they can affect the cardiovascular system 3. Become familiar with the histologic features of the common inflammatory aortic diseases, know the current classification for aortic disease DERMATOPATHOLOGY Zebras in Dermatopathology: Relatively Rare Entities That May Be Missed in a Skin Biopsy with Serious Consequences TUESDAY, MARCH 7, :30 PM-9:30 PM CC 302 MODERATOR: PANELISTS: Victor G. Prieto, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX Aeree Kim, MD, Korea University Guro Hospital, Seoul, Korea Phyu Aung, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX Rami Al-Rohil, Vanderbilt University, Nashville, TN Gonzalo de Toro, MD, Hospital de Puerto Montt, Puerto Montt, Chile George Jour, MD, MD Anderson at Cooper-Cooper University Hospital, Camden, NJ Upon completion of this activity, participants should be able to: 1. Understand and apply to their practice: Histopathologic criteria, Immunohistochemical studies, and the use of molecular and genetic studies in the analysis of cutaneous neoplastic lesions 71

104 EVENING SPECIALTY CONFERENCES TUESDAY NEUROPATHOLOGY Integrated Diagnosis, Texas Style (Bigger and Better) TUESDAY, MARCH 7, :30 PM-9:30 PM CC 303 MODERATOR: PANELISTS: Arie Perry, MD, University of California San Francisco, San Francisco, CA Suzanne Powell, MD, Houston Methodist Hospital, Houston, TX Alex Judkins, MD, Children s Hospital of Los Angeles, Los Angeles, CA Christine Fuller, MD, Cincinnati Children s Hospital, Cincinnati, OH Anthony Yachnis, MD, University of Florida, Gainesville, FL Fausto J. Rodriguez, MD, Johns Hopkins University, Baltimore, MD Upon completion of this activity, participants should be able to: 1. Recognize integrated diagnoses now being defined by the WHO 2016 classification scheme for CNS tumors 2. Identify commonly used Immunohistochemical biomarkers that are useful in the daily practice of surgical neuropathology 3. Appreciate which molecular markers in surgical neuropathology are primarily diagnostic (i.e., part of the integrated diagnosis) versus prognostic or predictive SURGICAL PATHOLOGY Mimics in Surgical Pathology TUESDAY MARCH 7, :30 PM-9:30 PM CC SNB 3&4 MODERATOR: PANELISTS: Kumarasen Cooper, MBChB, DPhil, University of Pennsylvania Hospital, Philadelphia, PA Bobbi Pritt, MD, Mayo Clinic, Rochester, MN Wayne Grayson, MBChB, PhD, University of Witwatersrand, South Africa Monalisa Sur, MBBS, McMaster University, Hamilton, Ontario, Canada John Wojcik, MD, PhD, University of Pennsylvania, Philadelphia, PA Maria Martinez-Lage, MD, Harvard University, Boston, MA Upon completion of this activity, participants should be able to: 1. Familiarize with a variety of mimics in surgical pathology 2. Appreciate mimics in tumor pathology: benign vs malignant and vice versa 3. Identify and recognize mimics of micro-organisms in surgical pathology 72

105 EVENING SPECIALTY CONFERENCES WEDNESDAY BREAST PATHOLOGY A Case That Taught Me Something WEDNESDAY, MARCH 8, :30 PM-9:30 PM CC 221 AB MODERATOR: PANELISTS: Jean Simpson, MD, Breast Pathology Consultants, Nashville, TN Andrea Kahn, MD, University of South Alabama, Mobile, AL Hannah Wen, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, NY Fouad Boulos, MD, American University of Beirut Medical Center, Beirut, Lebanon Kalliopi Siziopikou, MD, PhD, Northwestern University, Chicago, IL Melinda Sanders, MD, Vanderbilt University, Nashville, TN Upon completion of this activity, participants should be able to: 1. Recognize the salient diagnostic features of selected breast lesions 2. Integrate the imaging and pathology findings in the appropriate clinical context 3. Recognize the clinical management implications GASTROINTESTINAL PATHOLOGY You Don t See That Every Day: Non-Routine Diagnosis in Routine Cases WEDNESDAY, MARCH 8, :30 PM-9:30 PM CC 221 CD MODERATOR: PANELISTS: Rhonda Yantiss, MD, Weill Cornell Medical College, New York, NY Audrey Lazenby, MD, University of Nebraska, Omaha, NE Nicole Panarelli, MD, Albert Einstein School of Medicine, New York, NY Joseph Misdraji, MD, Massachusetts General Hospital, Boston, MA Kenneth Batts, MD, Allina Healthcare, Minneapolis, MN Thomas Smyrk, MD, Mayo Clinic, Rochester, MN Upon completion of this activity, participants should be able to: 1. Recognize key features of IBD-related neoplasia and distinguish them from their mimics 2. Identify subtle histologic features that allow one to classify colitis in mucosal biopsy samples 3. Familiarize themselves with differential diagnosis and infectious mimics of macrophage-rich infiltrates in samples of the GI tract 73

106 EVENING SPECIALTY CONFERENCES WEDNESDAY INFECTIOUS DISEASE PATHOLOGY Fungus in Formalin WEDNESDAY, MARCH 8, :30 PM-9:30 PM CC 225 CD MODERATOR: PANELISTS: Atis Muehlenbachs, MD, PhD, Centers for Disease Control and Prevention, Atlanta, GA Alejandro Velez Hoyos, Hospital Pablo Tobón Uribe, Medellín, Columbia Bobbi Pritt, MD, Mayo Clinic, Rochester, MN Gary Procop, MD, Cleveland Clinic, Cleveland, OH Shawn Lockhart, PhD, Centers for Disease Control and Prevention, Atlanta, GA Upon completion of this activity, participants should be able to: 1. Recognize the morphologic differential of fungi in tissue and their mimics 2. Recognize when molecular tests are indicated to further characterize fungal organisms 3. Interpret molecular test results and their pitfalls for fungal identification from pathology specimens RENAL PATHOLOGY Great Kidney Cases with Key Teaching Points WEDNESDAY, MARCH 8, :30 PM-9:30 PM CC 225 AB MODERATORS: PANELISTS: Vanesa Bijol, MD, Brigham and Women s Hospital, Boston, MA Tibor Nadasdy, MD, The Ohio State University, Columbus, OH Cynthia C. Nast, MD, Cedars-Sinai Medical Center, Los Angeles, CA Harsharan K. Singh, MD, The University of North Carolina, Chapel Hill, NC Christopher Larsen, MD, Arkansas Laboratories, Little Rock, AR Priya Mariam Alexander, MD, Mayo Clinic, Rochester, MN Laura Barisoni, MD, University of Miami, Miami, FL Upon completion of this activity, participants should be able to: 1. Work up the renal biopsy cases to the highest standard of practice based on clinical presentation of individual patients 2. Demonstrate the ability to identify and explain the etiology, pathogenesis, relevant investigations, and the differential diagnosis of discussed entities 3. Correlate the important clinical features of the disease with the pathologic changes 74

107 EVENING SPECIALTY CONFERENCES THURSDAY GYNECOLOGIC PATHOLOGY Lower Genital Tract Carcinomas in the Post-HPV Vaccination Era THURSDAY, MARCH 9, :30 PM-9:30 PM CC 221 MODERATOR: PANELISTS: C. Blake Gilks, MD, Vancouver General Hospital, Vancouver, BC, Canada Kay Park, MD, Memorial Sloan-Kettering Hospital, New York, NY Brooke Howitt, MD, Brigham and Women s Hospital, Boston, MA Blaise Clarke, MBBCh, University of Toronto, Toronto, Ontario, Canada Hugo Horlings, MD, PhD, Netherlands Cancer Institute, Amsterdam, Netherlands Upon completion of this activity, participants should be able to: 1. Understand the range and clinical significance of HPV-independent carcinoma of the lower female genital tract 2. Recognize the histopathological features of HPV-independent cervical adenocarcinomas and vulvar squamous and adenocarcinomas 3. Effectively use immunohistochemistry and molecular diagnostics in diagnosis of HPV-independent lower genital tract carcinomas HEAD AND NECK, AND ENDOCRINE PATHOLOGY What s New and Challenging in Head and Neck, and Endocrine Pathology? THURSDAY, MARCH 9, :30 PM-9:30 PM CC 301 MODERATOR: PANELISTS: Ilan Weinreb, MD, University Health Network, Toronto, Ontario, Canada Martin Bullock, MD, FRCPC, Dalhousie University, Halifax, NS, Canada Isabel Fonseca, MD, PhD, Instituto de Anatomia Patològica Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal Michelle Williams, MD, The University of Texas MD Anderson Cancer Center, Houston, TX Raja Seethala, University of Pittsburgh Medical Center, Pittsburgh, PA Upon completion of this activity, participants should be able to: 1. Recognize the causes of squamous morphology in the thyroid 2. Recognize new salivary gland tumors, including high-grade or aggressive variants 3. Understand the role of molecular testing in difficult head and neck cases with unusual features 75

108 EVENING SPECIALTY CONFERENCES THURSDAY PULMONARY PATHOLOGY It s in the Chest, but it is not Lung THURSDAY, MARCH 9, :30 PM-9:30 PM CC 225 AB MODERATOR: PANELISTS: Alain Borczuk, MD, Cornell University Medical Center, New York, NY Cesar Moran, MD, MD Anderson Cancer Center, Houston, TX Tamar Giorgadze, MD, PhD, Weill Cornell Medical School, New York, NY Neda Kalhor, MD, The University of Texas MD Anderson Cancer Center, Houston, TX Saul Suster, MD, The Medical College of Wisconsin, Milwaukee, WI Julia Geyer, MD, New York-Presbyterian Hospital, New York, NY Upon completion of this activity, participants should be able to: 1. Sharpen existing expertise in mediastinal pathology to distinguish primary pulmonary from primary mediastinal tumors 2. Recognize unusual variants of thymic neoplasia 3. Identify pitfalls in the diagnosis of lymphoproliferative processes of the mediastinum as distinct from thymic tumors 4. Effectively use immunohistochemistry in the diagnosis of extra-pulmonary thoracic cytology 76

109 SPECIAL COURSES #IAMUSCAP #USCAP2017

110 THE NUMBERS ARE IN! IMPRESSIONS 28,787,598 PARTICIPANTS TWEETS 19,298 1,369 AVG. TWEETS/PARTICIPANT 19 Our dynamic Twitter Team united the USCAP community in 2016 and celebrated its success at #USCAP2016. Thank you for sharing the excitement and energy of the Annual Meeting in Seattle! Keep the buzz going. AVG. TWEETS/HOUR 73 #IAMUSCAP #USCAP2017 #USCAP2017 #IAMUSCAP

111 SPECIAL COURSES SPECIAL COURSE Residents Workshop: Genomic Medicine for Pathologists: What You Need to Know SATURDAY, MARCH 4, :00 AM 5:00 PM CC 221 A COURSE DIRECTOR: Richard Haspel, MD, PhD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA FACULTY: Laura Tafe, MD, Dartmouth-Hitchcock Medical Center, Lebanon, NH COURSE DESCRIPTION: Next-generation sequencing methods and multi-gene panels have entered clinical practice. Pathologists, as directors of molecular pathology laboratories, are already playing a leading role in applying genomic technology to patient care. Regardless of your planned specialty, genomic pathology will become an important part of your career as a pathologist. Using a case-based, interactive small-group approach, workshop participants will learn principles related to the development of genomic assays and interpretation of results. The workshop will also include practical hands-on instruction with the use of online genomic pathology tools. The workshop was developed and will be led by members of the Training Resident in Genomics (TRIG) Working Group. Established in 2010, this group made up of experts in molecular pathology, medical education, and genetic counseling was formed to provide genomic pathology educational resources. The workshop will utilize a team-based learning approach. While there will be short lectures at the beginning and end of each session, the majority of learning will take place in small resident teams with faculty support. Upon completion of this educational activity, participants should be able to: Determine the clinical significance of genetic variants, using online tools Describe the benefits and limitations of integrative genomic analyses Describe the reporting issues related to genomic analyses 9:00 AM SESSION 1: SINGLE GENE TESTING Upon completion of this educational activity, participants should be able to: List the factors that go into the determination of who is an appropriate candidate for cancer susceptibility genetic testing Determine the clinical significance of variant related to cancer susceptibility genetic testing, with the use of online tools 10:30 AM COFFEE BREAK 10:45 AM SESSION 2: PROGNOSTIC GENE-PANEL TESTING 12:15 PM LUNCH Upon completion of this educational activity, participants should be able to: Describe the role of pathologists in facilitating prognostic gene-panel testing Compare utility of prognostic gene-panel testing to histologic methods Interpret a prognostic gene panel report and consider important components to ensure appropriate interpretation by the ordering clinician Describe the process of selecting genes for expression profiles for clinical use 1:00 PM SESSION 3: DESIGN OF A MULTIGENE ASSAY (CANCER GENE PANEL) Upon completion of this educational activity, participants should be able to: Describe different methods for detecting DNA variants (PCR vs. Sanger-based vs. NGS-based) Determine the appropriate methodology for a selected gene panel Describe the factors that determine the utility of inclusion of a specific gene in a multigene assay (in this case, a cancer gene panel) 77

112 SPECIAL COURSES 2:30 PM COFFEE BREAK Residents Workshop: Genomic Medicine for Pathologists: What You Need to Know...cont. 2:45 PM SESSION 4: WHOLE EXOME SEQUENCING Upon completion of this educational activity, participants should be able to: Describe key aspects of informed consent for genomic analyses Describe the benefits and limitations of integrative genomic analyses for advanced cancer patients Describe the reporting issues related to unintended findings Use online tools to interpret the clinical significance of genomic data 4:15 PM WRAP-UP/QUESTION AND ANSWER SESSION 78

113 SPECIAL COURSES SPECIAL COURSE Facebook, Twitter, Instagram, et al: Everything a Pathologist Needs to Know to be a Social Media Pro MONDAY, MARCH 6, :00 AM 12:00 PM CC HEMISFAIR 2 COURSE DIRECTOR: Jerad M. Gardner, MD, University of Arkansas for Medical Sciences, Little Rock, AR COURSE DESCRIPTION: Any pathologist or pathologist in training with an interest in using social media as a professional tool would benefit from this course. This includes general pathologists, subspecialty pathologists, residents, and fellows. The course material and potential benefits will be accessible to all attendees regardless of their level of experience with social media (i.e. both beginners who have never used social media and advanced users who have been using social media for years should benefit from this course; prior experience with social media is not required). Beginners will learn the basic features and how to get started on social media and how to gain familiarity with using it. More advanced users will learn about new opportunities to explore (e.g. involvement in cancer patient support groups on Facebook) as well as how to branch out to other platforms beyond their currently favored one (e.g. a pro user of Facebook will learn how to use Twitter and Instagram). The curriculum will provide an opportunity for participants to undertake a guided exploration of the following areas of study: Compare and contrast the different major social media platforms (e.g. Facebook, Twitter, Instagram, LinkedIn) Acquire the basics of how to create professional social media accounts and use them Discover a variety of potential pathology-related professional applications for social media Discuss concepts behind development of a practical and effective social media strategy for individual pathologists to enhance their professional careers Discuss the potential uses of social media for pathology professional societies, pathology departments, or other professional organizations Discuss the risks of social media and how to mitigate them 8:00 AM INTRODUCTION AND OBJECTIVES 8:10 AM REVIEW OF 4 MAIN SOCIAL MEDIA SITES: FACEBOOK, TWITTER, INSTAGRAM, LINKEDIN 8:30 AM BASICS OF USING SOCIAL MEDIA (HOW TO POST/TWEET, FOLLOW, LIKE, ETC) 8:40 AM PRACTICE TWEETING/POSTING WITH CRITIQUE, ASSISTANCE, AND Q & A BY DR. GARDNER 8:50 AM DIFFERENT IDEAS FOR HOW PATHOLOGISTS CAN USE SOCIAL MEDIA PROFESSIONALLY Upon completion of this educational activity, participants should be able to: Engage in Facebook pathology discussion groups Share pathology images, articles, and other content via Twitter Network with pathologists using social media Perform research collaboration and crowdsourcing Understand patient support group involvement Promote advocacy for pathologists using social media 9:20 AM ROLE OF SOCIAL MEDIA IN CAREER BUILDING AND BRAND BUILDING FOR PATHOLOGISTS Upon completion of this educational activity, participants should be able to: Explain what is my "brand" and how do I build it Identify ways social media can directly benefit your career Understand how to get your social media activity recognized as real professional work 9:50 AM COFFEE BREAK 79

114 SPECIAL COURSES Facebook, Twitter, Instagram, et al: Everything a Pathologist Needs to Know to be a Social Media Pro...cont. 10:50 AM ROLE OF SOCIAL MEDIA IN PATHOLOGY DEPARTMENTS AND PROFESSIONAL ORGANIZATIONS Upon completion of this educational activity, participants should be able to: Build an online presence beyond a website Interact with and gain followers and fans Distinguish between personal and business social media accounts 11:20 AM RISKS OF SOCIAL MEDIA (WHAT NOT TO DO ON FACEBOOK!) WITH CASE EXAMPLES 11:35 AM QA SESSION WITH DISCUSSION 80

115 SPECIAL COURSES SPECIAL COURSE Clinical Application of Next Generation Sequencing for the Management of Patients with Solid Tumors MONDAY, MARCH 6, :00 AM 12:00 PM CC 221 COURSE DIRECTOR: Jeffrey S. Ross, MD, Albany Medical Center, Albany, NY and Foundation Medicine, Inc., Cambridge, MA COURSE CO-DIRECTORS: Neal I. Lindeman, MD, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA Stephen Yip, MD, PhD, University of British Columbia and Vancouver General Hospital, Vancouver, BC COURSE DESCRIPTION: This half-day course is designed to familiarize the registrant with both the technical aspects and clinical applications of NGS for the solid tumor cancer patient. The first section of the course is organized into a didactic series of short lectures given by the course instructors to highlight the history of clinical DNA sequencing on cancer specimens focused on the search for potential therapy targets for patients with relapsed and refractory disease. The technical section will emphasize practical issues for pathologists including the types of samples that can be used, the quantity and proportion of tumor cells needed and the pre-analytic factors that can influence NGS test results. Both formalin fixed paraffin embedded tissues and blood-based liquid biopsies will be considered. The remaining sections of the course will consist of a case by case analysis that includes lung cancer, breast cancer, colorectal cancer, melanoma, brain tumors and cancer of unknown primary origin. Upon completion of this educational activity, participants should be able to: Contrast the differences, advantages and disadvantages between next generation sequencing (NGS) technologies and traditional Sanger Sequencing methods Understand the current limitations of one off" single gene hotspot sequencing tests versus comprehensive genomic profiling by NGS Contrast the advantages and disadvantages of the targeted NGS panel approach versus whole exome and whole genome sequencing Understand how next generation sequencing technologies can be applied to detect all classes of genomic alterations including base substitutions, short insertions/deletions, fusions and translocations, and copy number alterations including amplifications and homozygous deletions in a clinical grade, regulatory agency approved (CLIA/CAP) format using routine clinical FFPE samples Know how to preserve and prepare surgical pathology and cytologic samples including fluids and fine needle aspirations for NGS testing Contrast the uses and limitations of using a blood sample for analysis of circulating tumor cell and cell free DNA for NGS Be familiar with the potential of NGS to alter a cancer patient s clinical outcome by identifying a genomic alteration that can lead to a specific targeted therapy that would not have been considered if the NGS results had not been available Have a basic understanding of assessing quality assurance, proficiency testing and general validation of NGS procedures used in clinical testing of patient samples 8:00 AM INTRODUCTORY LECTURES: HISTORY OF DNA SEQUENCING, TRADITIONAL AND NGS SEQUENCING TECHNOLOGIES AND THE ROLES OF PATHOLOGISTS IN THE PROVIDING OF NGS RESULTS DESIGNED TO DIRECT PERSONALIZED CANCER TREATMENT 9:20 AM CASE 1: NON-SMALL CELL LUNG CANCER 9:40 AM CASE 2: BREAST CANCER 10:00 AM COFFEE BREAK 10:20 AM CASE 3: MELANOMA 10:40 AM CASE 4: COLORECTAL CANCER 11:00 AM CASE 5: CANCER OF UNKNOWN PRIMARY ORIGIN 11:20 AM CASE 6: BRAIN TUMORS 11:40 AM QUESTIONS AND DISCUSSION 81

116 SPECIAL COURSES SPECIAL COURSE The Insider s Guide to Quality and Safety MONDAY, MARCH 6, :00 PM 5:00 PM CC HEMISFAIR 2 COURSE DIRECTOR: Yael K. Heher, MD, MPH, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA COURSE CO-DIRECTOR: Raouf Nakhleh, MD, Mayo Clinic Florida, Jacksonville, FL COURSE DESCRIPTION: Pathologists have long been deeply invested in the quality of the care we provide. However, the increasing burden of clinical care, daily operations, and regulatory compliance have challenged the maintenance of a safe and high quality care environment. In parallel to increasing clinical demands, the health care community has become sharply focused on patient safety, with many major organizations calling on the laboratory to adapt to a culture of reliability, accountability, and transparency. Despite these shifts in the healthcare landscape, little to no specific tools exist to guide anatomic pathologists on exactly how to investigate medical errors and carry out quality improvement initiatives. This half day course will provide such a tool kit for frontline pathologists and pathologists-in-training. The course will be heavily casebased and interactive, utilizing a set of validated tools from the quality and safety literature and practical pathology-specific applications to facilitate learning. Upon Completion of this educational activity, participants should be able to: Understand the scope and breadth of quality and patient safety in anatomic pathology Utilize published quality principles to reduce risk of diagnostic error in surgical pathology Evaluate adverse events and near misses thoroughly and honestly using root cause analysis and the M&M model Effectively analyze and target root causes that may have contributed to failure using validated process improvement tools Optimize and standardize the pathology report as a communication tool to reduce errors and improve care Understand the role of process mapping and workflow redesign in successful quality improvement initiatives Describe the necessary elements of disclosure and the adverse event management process Comfortably discuss and resolve common challenging scenarios in quality and patient safety for pathologists 1:00 PM INTRODUCTORY LECTURE: WHAT IS QUALITY AND SAFETY IN THE LAB? 1:20 PM CASE 1: DIAGNOSTIC ERROR IN SURGICAL PATHOLOGY: HOW CAN WE REDUCE RISK? 1:40 PM CASE 2: M&M ROUNDS IN PATHOLOGY: ROOT CAUSE ANALYSIS, TRANSPARENCY, AND PROCESS IMPROVEMENT 2:00 PM COFFEE BREAK 2:30 PM CASE 3: COMMUNICATION IN PATHOLOGY: A MODEL OF POST-ANALYTIC QUALITY 2:50 PM CASE 4: HISTOLOGY LABELING ERROR: PROCESS MAPPING AND WORKFLOW REDESIGN 3:10 PM CASE 5: WHEN THINGS GO WRONG: DISCLOSURE AND ADVERSE EVENT MANAGEMENT 3:30 PM COFFEE BREAK 4:00 PM COMMON CHALLENGES IN QUALITY & SAFETY: ROLE PLAY SESSION 4:40 PM QUESTIONS AND DISCUSSION 82

117 SPECIAL COURSES SPECIAL COURSE Tumor Immunology: Implications for TNM Staging and Therapeutics MONDAY, MARCH 6, :00 PM 5:00 PM CC 221 COURSE DIRECTORS: Janis M. Taube, MD, The Johns Hopkins University School of Medicine, Baltimore, MD Robert A. Anders, MD, PhD, The Johns Hopkins University School of Medicine, Baltimore, MD COURSE DESCRIPTION: The recent success of immune based cancer therapy is changing the practice of pathology. In order to prepare practicing pathologists this course will explain the current and future approach to evaluating patient specimens. This course will specifically address TNM-Immune staging and the emerging use of surgical pathology specimens for immune-based assays, including immunologic biomarkers for therapeutic selection and monitoring. Upon conclusion of the course, participants will be able to address questions they receive from treating physicians, oncologists and patients regarding predictive and prognostic immune biomarkers, histologic features of adverse immune reactions and evaluation PD-L1 immunohistochemistry. Upon completion of this educational activity, participants should be able to: Summarize how the activity of checkpoint agents differs from that of more traditional therapeutics Summarize the latest concepts regarding the immune contexture of malignant neoplasms Discuss the histologic features associated with adaptive immune resistance Understand the limitations of PD-L1 evaluation I dentify additional markers and associated detection techniques that will likely be employed in future Immunopathology assays 1:00 PM IMMUNE CHECKPOINTS, CHECKPOINT BLOCKADE THERAPY, AND RATIONAL PATIENT SELECTION: AN OVERVIEW Janis M. Taube, MD, The Johns Hopkins University School of Medicine, Baltimore, MD Upon completion of this educational activity, participants should be able to: Summarize how the activity of checkpoint agents differs from that of more traditional therapies Describe possible immune-related side effects and the associated pathologic features from these agents Summarize recent FDA approvals for this class of therapeutics and the associated companion/complimentary diagnostics 1:30 PM THE IMMUNOSCORE Jerome Galon, MD, PhD, Cordeliers Research Center, Paris, France Upon completion of this educational activity, participants should be able to: Summarize how the Immunoscore performs compared to current TNM staging Understand how an Immunoscore is calculated Discuss the current status of the Immunoscore Task Force in validating this approach 2:00 PM PD-L1 IHC ASSAYS: WHAT IS THE DIFFERENCE AND WHAT IS NEXT David Rimm, MD, PhD, Yale University School of Medicine, New Haven, CT Upon completion of this educational activity, participants should be able to: Describe differences and similarities of current chromogenic IHC testing methods for PD-L1 Understand the strengths and limitations of pathologist reading of these assays Describe methods beyond chromogenic IHC for measuring PD-L1 and other PD-L1 related parameters to predict response to PD-1 axis therapies 2:30 PM RESULTS OF CHECK POINT INHIBITION IN PATIENTS WITH COLON CANCER Robert A. Anders, MD, PhD, The Johns Hopkins University School of Medicine, Baltimore, MD Upon completion of this educational activity, participants should be able to: Understand the importance of mismatch repair deficiency in colon cancer patients considering immune based chemotherapy Summarize the results of the anti-pd-1 clinical trial in colon patients Discuss the limitation of PD-L1 expression as a clinical predictive biomarker 83

118 SPECIAL COURSES Tumor Immunology: Implications for TNM Staging and Therapeutics...cont. 3:00 PM COFFEE BREAK 3:30 PM THE BREAST TUMOR IMMUNE MICROENVIRONMENT Ashley Cimino-Mathews, MD, The Johns Hopkins University School of Medicine, Baltimore, MD Upon completion of this educational activity, participants should be able to: Identify the components of the breast tumor immune microenvironment Compare and contrast the tumor microenvironment of in situ and invasive breast carcinoma Discuss the features of the tumor microenvironment unique to special subtypes of invasive carcinoma 4:00 PM NON-SMALL CELL LUNG CARCINOMA: THE TUMOR IMMUNE MICROENVIRONMENT Lynette M. Sholl, MD, Brigham and Women s Hospital, Boston, MA Upon completion of this educational activity, participants should be able to: Identify components of the NSCLC tumor immune microenvironment Compare and contrast treatment indications and PD-L1 assay strategies for lung squamous cell carcinoma vs. adenocarcinoma Discuss potential immune cell and tumor biomarkers beyond PD-L1 and their potential relationship to therapeutic outcomes 84

119 SPECIAL COURSES SPECIAL COURSE Molecular Diagnostic and Genomic Applications in Cancer: A Primer for the Pathologist TUESDAY, MARCH 7, :00 AM 5:15 PM CC HEMISFAIR 2 COURSE DIRECTORS: George J. Netto, MD, The University of Alabama at Birmingham, Birmingham, AL Karen Kaul, MD, PhD, North Shore University Health System, Evanston, IL COURSE DESCRIPTION: The pathologist is increasingly expected to play a central role in the management of cancer patients in the era of personalized oncology. Molecular diagnostic and genomic applications are rapidly penetrating the daily practice of the pathologist as the list of actionable genetic alteration in solid and hematologic tumors continues to expand. As highlighted in the USCAP 2012 combined companion meeting of the Association for Molecular Pathology Joint Meeting with American Society for Clinical Pathology in Coordination with American Society for Investigative Pathology, efforts to develop residency curricula that will address the educational needs in molecular and genomic pathology for pathologists in training are underway by some academic institutions and others. These initiatives include the efforts sponsored by the Training Residents in Genomics (TRIG) working group of the Pathology Residency Directors Section of the Association of Pathology Chairs. Similar educational needs are evident among practicing pathologists in the community and academic centers, pathology residents and fellows in institutions that are yet to develop a formal curriculum. A survey of the positive responses from attendees of the sold out special course titled Basic Principles and Practice of Molecular Pathology in Cancer, which was in its final iteration at USCAP 2012, is very indicative of an urgent and important educational need. The current course proposal intends to build upon and extend the role that the latter course, that is no longer offered, fulfilled. In fact, the proposal stems from the shared recognition of the AMP, ASIP and ASCP organizations that sponsored the 2012 combined companion meeting and from the director and faculty of the previous special course that there is the continuous need to offer educational opportunities to augment medical knowledge and to address competency deficiencies among the intended target audience, which is, primarily, the group of anatomic pathologists. Upon completion of this educational activity, participants should be able to: Select the appropriate and most cost-effective molecular and cytogenetic testing for workup of lymphomas and tissue-based leukemic infiltrates of various types Assess the technology, limitations and benefits of next generation mutation, array and transcriptional profiling in lymphomas Describe the emerging role of exome/whole genome sequencing in the management of patients with lymphoma 8:00 AM INTRODUCTION George J. Netto, MD, The University of Alabama at Birmingham, Birminham, AL 8:10 AM CURRENT NEXT GENERATION SEQUENCING TECHNOLOGY: A PRIMER TO THE ANATOMIC PATHOLOGIST Wayne W. Grody, MD, PhD, University of California Los Angeles School of Medicine, Los Angeles, CA Upon completion of this educational activity, participants should be able to: Discuss the overall principles of massively parallel sequencing (next generation sequencing) technologies Illustrate practical examples of NGS based clinical diagnostics and how it will be impacting daily practice of pathology 8:50 AM NEXT-GEN SURGICAL PATHOLOGY: NEW OPPORTUNITIES AND CHALLENGES Karen Kaul, MD, PhD, North Shore University Health System, Evanston, IL Upon completion of this educational activity, participants should be able to: Discuss how the evolving understanding of molecular events underlying cancer development is making molecular characterization of tumors a necessity for diagnosis and prognostication in the practice of the pathologist Present an overview of the evolution of molecular testing from single gene or mutation analysis to multiplex capabilities including next generation sequencing Discuss the challenges and opportunities associated with the incorporation of these tools into the daily practice of the pathologist 85

120 SHORT COURSES Molecular Diagnostic and Genomic Applications in Cancer: A Primer for the Pathologist...cont. 9:20 AM MOLECULAR MARKERS FOR TARGETED LUNG CANCER THERAPY John Iafrate, MD, PhD, Massachusetts General Hospital, Boston, MA Upon completion of this educational activity, participants should be able to: State the current genetic landscape of lung tumors Identify the role of genetic testing in guiding targeted therapies in lung cancer Appreciate the importance of advanced technologies in the future of pathologic assessment of tumors 10:00 AM COFFEE BREAK/POSTER SESSION 10:30 AM MOLECULAR TESTING IN THE MANAGEMENT OF PATIENTS WITH BREAST CANCER: CURRENT STATUS AND FUTURE DIRECTIONS Stuart J. Schnitt, MD, Beth Israel Deaconess Medical Center, Boston, MA Upon completion of the educational activity, participants should be able to: Explain the molecular classification of breast cancer and its clinical implications Review the uses and limitations of currently available molecular prognostic tests for patients with breast cancer Describe the emerging role of exome /whole genome sequencing in the management of patients with breast cancer 11:00 AM CLINICAL CYTOGENETIC AND MOLECULAR GENETIC TESTING IN BONE AND SOFT TISSUE TUMORS Julia A. Bridge, MD, University of Nebraska Medical Center, Omaha, NE Upon completion of this educational activity, participants should be able to: Review sample requirements and handling for RT-PCF, FISH, and cytogenetic analysis as they pertain to evaluating mesenchymal neoplasms Describe the advantages and limitations of genetic approaches commonly used in the classification of mesenchymal neoplasms to include conventional karyotyping, FISH and RT-PCR Recognize the diagnostic, prognostic, and therapeutic value of molecular markers in mesenchymal neoplasia 11:40 PM GIST AND MELANOMA: THE KIT CONNECTION AND SO MUCH MORE Alexander Lazar, MD, PhD, University of Texas M. D. Anderson Cancer Center, Houston, TX Upon completion of this educational activity, participants should be able to: Illustrate the techniques and results of molecular testing for gastrointestinal stromal tumor (GIST) and melanoma Recognize the association between histologic and molecular features in GIST and melanoma Interpret the emerging role of molecular diagnostics in patient management for GIST and melanoma 12:10 PM LUNCH BREAK 1:10 PM MOLECULAR DIAGNOSTICS OF LYMPHOMA: ASSAYS FOR CLASSIFICATION, OUTCOME PREDICTION AND THERAPY RESPONSE Dan Jones, MD, PhD, The Ohio State University College of Medicine, Columbus, OH Upon completion of this educational activity, participants should be able to: Select the appropriate and most cost-effective molecular and cytogenetic testing for workup of lymphomas and tissue-based leukemic infiltrates of various types Assess the technology, limitations and benefits of next generation mutation, array and transcriptional profiling in lymphomas Describe the emerging role of exome/whole genome sequencing in the management of patients with lymphoma 1:50 PM COLORECTAL CANCER: MOLECULAR TESTING FOR THE SURGICAL PATHOLOGIST Kevin C. Halling, MD, PhD, Mayo Clinic, Rochester, MN 86

121 SPECIAL COURSES Molecular Diagnostic and Genomic Applications in Cancer: A Primer for the Pathologist...cont. Upon completion of this educational activity, participants should be able to: Discuss how MSI and DNA mismatch repair IHC testing and germline DNA mismatch repair gene sequencing are used to identify, diagnose, and manage patients with HNPCC Explain how microsatellite instability testing can be used to assess stage II and III CRC patients prognosis and response to 5FU treatment Describe how KRAS and BRAF testing can be used to predict response to anti-egfr therapies for patients with metastatic colorectal cancer (CRC) Describe the emerging role of exome/whole genome sequencing in the management of patients with colorectal cancer 2:30 PM EMERGING IMMUNOLOGIC BIOMARKERS: PD-L1 AND BEYOND Janis Taube, MD PhD, The Johns Hopkins University, Baltimore, MD Upon completion of this educational activity, participants should be able to: Introduce the CTLA-4/CD80 or CD86 and PD-1/PD-L1 checkpoints, including physiologic and pathologic expression Discuss the association of immunoarchitectural features of the tumor microenvironment and relationship to response with anti-pd-1/pd-l1 checkpoint blockade Compare available assays for PD-L1 detection in surgical pathology specimens 3:00 PM COFFEE BREAK/POSTER SESSION 3:30 PM MOLECULAR DIAGNOSTICS OF CNS TUMORS Arie Perry, MD, University of California San Francisco School of Medicine, San Francisco, CA Upon completion of this educational activity, participants should be able to: Review the most common molecular alterations in CNS tumors Recognize the association between histologic and molecular features in CNS tumors Interpret the emerging role of molecular diagnostics in patient management for CNS tumors 4:00 PM ROLE OF THE PATHOLOGIST IN GUIDING IMMUNO-ONCOLOGICAL THERAPIES Scott Rodig, MD, PhD, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Upon completion of this educational activity, participants should be able to: Review clinical outcomes in melanoma, lung cancer, bladder cancer, hematological malignancies to novel immunotherapies Discuss histopathological and genetic correlates leukemia of clinical response to immunotherapy Review current applications of diagnostic pathological methods to guide immunotherapy Describe development of future diagnostic methods to guide immunotherapy 4:30 PM MOLECULAR DIAGNOSTICS OF HEAD AND NECK TUMORS Justin Bishop, MD, Johns Hopkins University, Baltimore, MD Upon completion of this educational activity, participants should be able to: Review HPV-related Oropharyngeal SCC entities (locations, prognosis, histology) Discuss HPV testing strategies in the Head & Neck tumors Discuss newly described tumor-defining translocations in salivary gland tumors 5:00 PM QUESTION PERIOD AND CONCLUDING REMARKS George J. Netto, MD, The University of Alabama at Birmingham, Birmingham, AL 87

122 SPECIAL COURSES INTERACTIVE MICROSCOPY *** All Interactive Microscopy Courses will be held at the River Center on the 3rd Floor*** MONDAY, MARCH 6, :00 AM 9:30 AM ODONTOGENIC CYSTS AND TUMORS David E. Klingman, DMD, Uniformed Services University of the Health Sciences, Bethesda, MD RC Conference Room 11 DIAGNOSTIC DILEMMAS IN SKIN ADNEXAL TUMOR PATHOLOGY Thomas Brenn, MD, Western General Hospital and The University of Edinburgh, Edinburgh, Scotland RC Conference Room 5 FATTY TUMORS OF THE RETROPERITONEUM Karen Fritchie, MD, Mayo Clinic, Rochester, MN RC Conference Room 6 MONDAY, MARCH 6, :00 AM 11:30 AM LYMPHOMA MIMICS: WHAT YOU DON T KNOW CAN HURT THEM Dennis P. O Malley, MD, O Malley Medical Consulting, Dana Point, CA RC Conference Room 6 KEY CONCEPTS IN NEOPLASMS OF THE EYE AND OCULAR ADNEXA: A PRACTICAL APPROACH Pablo Zoroquiain, MD, McGill University Health Center, Montreal, Quebec RC Conference Room 11 PRACTICAL APPROACHES IN INTERPRETATION OF RENAL MASS BIOPSY Steven Shen, MD, PhD, The Methodist Hospital, Houston, TX RC Conference Room 5 MONDAY, MARCH 6, :30 PM 3:00 PM ENDOMETRIAL PATHOLOGY-SELECTED CHALLENGING AND INFORMATIVE CASES Charles Quick, MD, University of Arkansas for Medical Sciences, Little Rock, AR RC Conference Room 6 PRACTICAL APPROACH TO PAPILLARY PROBLEMS AND OTHER DILEMMAS IN BREAST CORE NEEDLE BIOPSY INTERPRETATION Andrea Dawson, MD, Cleveland Clinic Foundation, Cleveland, OH RC Conference Room 11 UNUSUAL AND PROBLEM CASES IN HEAD AND NECK CYTOPATHOLOGY Paul Wakely Jr., MD, The Ohio State University Wexner Medical Center, Columbus, OH RC Conference Room 5 88

123 SPECIAL COURSES INTERACTIVE MICROSCOPY MONDAY, MARCH 6, :30 PM 6:00 PM GLIOMA DIAGNOSIS-2017: WHAT PATHOLOGISTS NEED TO KNOW Tony Yachnis, MD, University of Florida, Gainesville, FL RC Conference Room 6 WHAT CAN THE PLACENTA TELL US? Debra S. Heller, MD, Rutgers New Jersey Medical School, Newark, NJ RC Conference Room 11 MORPHOLOGY VS. MOLECULAR MARKERS IN GI BIOPSY DIAGNOSIS: HOW NOT TO GET TRIPPED UP WHEN INTEGRATING RESULTS! Marie Robert, MD, Yale University School of Medicine, New Haven, CT RC Conference Room 5 TUESDAY, MARCH 7, :00 AM 9:30 AM AN APPROACH TO INTRAOPERATIVE CONSULTATION IN NEUROPATHOLOGY Richard Prayson, MD, Cleveland Clinic, Cleveland, OH RC Conference Room 6 LOOK AT THAT BUG! INTERESTING INFECTIOUS DISEASE CASES Kathleen Montone, MD, University of Pennsylvania, Philadelphia, PA RC Conference Room 11 HIGH RISK NON-MELANOMA SKIN CANCERS: LESSONS FROM UV-DRENCHED NEW ZEALAND Patrick Emanuel, MD, Auckland District Health, Auckland, New Zealand RC Conference Room 5 TUESDAY, MARCH 7, :00 AM 11:30 AM A PRACTICAL APPROACH TO ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE ASPIRATION BIOPSY Longwen Chen, MD, PhD, Mayo Clinic Arizona, Scottsdale, AZ RC Conference Room 6 DIAGNOSTIC ISSUES IN DLBCL: A 2017 PERSPECTIVE Megan Lim, MD, Hospital of the University of Pennsylvania, Philadelphia, PA RC Conference Room 11 HEAD AND NECK PATHOLOGY: NEW INSIGHTS AND ENTITIES Vickie Jo, MD, Brigham and Women s Hospital, Boston, MA RC Conference Room 5 89

124 SPECIAL COURSES INTERACTIVE MICROSCOPY TUESDAY, MARCH 7, :30 PM 3:00 PM CHALLENGING GESTATIONAL TROPHOBLASTIC LESIONS-MORPHOLOGY AND BEYOND Natalia Buza, MD, Yale University, New Haven, CT RC Conference Room 6 DON T BE DUPED! LOOK-ALIKES IN GENITOURINARY PATHOLOGY Brian Robinson, MD, Weill Cornell Medical College, New York, NY RC Conference Room 11 SNEAKY GI BIOPSIES WITH HIDDEN DIAGNOSES: LESSONS IN APPLYING A SYSTEMATIC APPROACH Dora Lam-Himlin, MD, Mayo Clinic, Scottsdale, AZ RC Conference Room 5 TUESDAY, MARCH 7, :30 PM 6:00 PM LUNG CANCER CLASSIFICATION: CONTROVERSIES AND CHALLENGES Alain Borczuk, MD, Cornell University Medical Center, New York, NY RC Conference Room 6 MESENCHYMAL TUMORS OF THE BREAST: A CONCEPTUAL FRAMEWORK FOR THE PRACTICING PATHOLOGIST Jordi Rowe, MD, Cleveland Clinic, Cleveland, OH RC Conference Room 11 CORRELATION OF TUMOROUS AND NON-TUMOROUS CONDITIONS OF BONES AND JOINTS WITH CLINICAL IMAGING: HOW DOES THE PATHOLOGY CREATE THE IMAGING FEATURES AND WHAT YOU NEED TO KNOW ABOUT THEM Michael Klein, MD, The Hospital for Special Surgery, New York, NY RC Conference Room 5 WEDNESDAY, MARCH 8, :00 AM 9:30 AM AN APPROACH TO PROBLEMATIC VASCULAR TUMORS: BENIGN, BORDERLINE, MALIGNANT AND PSEUDO MALIGNANT Andrew L. Folpe, MD, Mayo Clinic, Rochester, MN RC Conference Room 6 UNCOMMON TYPES OF INVASIVE MAMMARY CARCINOMA Timothy D Alfonso, MD, Weill Cornell Medical College, New York, NY RC Conference Room 11 WHEN AND HOW TO USE MOLECULAR STUDIES IN THE DIAGNOSIS OF MELANOCYTIC LESIONS Doru Andea, MD, University of Michigan, Ann Arbor, MI RC Conference Room 5 90

125 SPECIAL COURSES INTERACTIVE MICROSCOPY WEDNESDAY, MARCH 8, :00 AM 11:30 AM THYMIC EPITHELIAL TUMORS AND ITS MIMICKERS, CHALLENGES AND PITFALLS OF ANTERIOR MEDIASTINAL TUMORS Anja C. Roden, MD, Mayo Clinic, Rochester, MN RC Conference Room 6 DIAGNOSTIC CHALLENGES IN HEAD AND NECK SURGICAL PATHOLOGY Theresa Scognamiglio, MD, New York Presbyterian Hospital, New York, NY RC Conference Room 11 PECULIAR POLYPS: DIAGNOSTICS OF LESS COMMON COLORECTAL LESIONS AND AWARENESS OF THEIR CLINICAL ASSOCIATIONS Jaclyn F. Hechtman, MD, Memorial Sloan Kettering Cancer Center, New York, NY RC Conference Room 5 WEDNESDAY, MARCH 8, :30 PM 3:00 PM FROZEN SECTION IN OVARIAN AND PERITONEAL LESIONS: CHALLENGES AND CONTROVERSIES Andres Roma, MD, University of California San Diego, San Diego, CA RC Conference Room 6 TRICKY THYROID TUMORS Justine A. Barletta, MD, Brigham and Women s Hospital, Boston, MA RC Conference Room 11 TUMOR AND TUMOR-LIKE PROLIFERATIONS OF THE SPLEEN Daniel Arber, MD, Stanford Medicine-Stanford Health Care, Stanford, CA RC Conference Room 5 WEDNESDAY, MARCH 8, :30 PM 6:00 PM INTERPRETATION OF INTESTINAL BIOPSY IN THE ERA OF PRECISION MEDICINE Xiuli Liu, MD, PhD, University of Florida, Gainesville, FL RC Conference Room 6 RECOGNIZING EARLY ORAL CANCER, HIGH-RISK PRECURSOR LESIONS AND MIMICS Mihai Merzianu, MD, Roswell Park Cancer Center, Buffalo, NY RC Conference Room 11 URINARY TRACT CYTOPATHOLOGY: USING THE PARIS SYSTEM TO IMPROVE YOUR PRACTICE Christopher J. VandenBussche, MD, The Johns Hopkins Hospital, Baltimore, MD RC Conference Room 5 91

126 SPECIAL COURSES INTERACTIVE MICROSCOPY THURSDAY, MARCH 9, :00 AM 9:30 AM SNEAKY CANCERS AND THEIR MIMICS Rhonda K. Yantiss, MD, Weill Cornell Medical College, New York, NY RC Conference Room 6 DIAGNOSTIC PITFALLS IN PROSTATE PATHOLOGY Adeboye O. Osunkoya, MD, Emory University School of Medicine, Atlanta, GA RC Conference Room 11 THE 2015 AMERICAN THYROID ASSOCIATION GUIDELINES: THE ROLE OF THE SURGICAL PATHOLOGIST IN THE MANAGEMENT OF DIFFERENTIATED THYROID CANCER Juan C. Hernandez-Prera, MD, H. Lee Moffitt Cancer Center, Tampa, FL RC Conference Room 5 THURSDAY, MARCH 9, :00 AM 11:30 AM MESENCHYMAL TUMORS OF THE UTERUS: AN UPDATE IN CLASSIFICATION, IMMUNOSTAINS, AND DIFFERENTIAL DIAGNOSIS Joseph Rabban, MD, University of California San Francisco, San Francisco, CA RC Conference Room 6 SURGICAL PATHOLOGY OF PANCREATOBILIARY TRACT N. Volkan Adsay, MD, Emory University Hospital, Atlanta, GA RC Conference Room 11 PATHOLOGY OF COMMON INTERSTITIAL LUNG DISEASES- THE ESSENTIALS FOR PRACTICING PATHOLOGISTS Carol Farver, MD, Cleveland Clinic, Cleveland, OH RC Conference Room 5 THURSDAY, MARCH 9, :30 PM 3:00 PM ACCURATE DIAGNOSIS OF RENAL TUMOR TYPES: NOT JUST AN ACADEMIC EXERCISE Pheroze Tamboli, MBBS, University of Texas MD Anderson Cancer Center, Houston, TX RC Conference Room 6 MEDICAL LIVER BIOPSIES-HOW TO STAY OUT OF TROUBLE John Hart, MD, University of Chicago, Chicago, IL RC Conference Room 11 DIAGNOSING HISTOLOGICALLY SUBTLE, YET CLINICALLY SIGNIFICANT, BREAST LESIONS ON NEEDLE CORE BIOPSIES Syed A. Hoda, MD, New York Presbyterian Hospital, New York, NY RC Conference Room 5 92

127 SPECIAL COURSES INTERACTIVE MICROSCOPY THURSDAY, MARCH 9, :30 PM 6:00 PM DIAGNOSTIC CHALLENGES IN CUTANEOUS SOFT TISSUE TUMORS Steven Billings, MD, Cleveland Clinic, Cleveland, OH RC Conference Room 6 OVERCOMING STAGE FRIGHT IN LUNG CANCER: MAKING SENSE OF HISTOLOGIC PARAMETERS THAT MATTER Kelly Butnor, MD, The University of Vermont Medical Center, Inc, Burlington, VT RC Conference Room 11 USING THE 2016 WHO CLASSIFICATION OF CNS TUMORS TO INFORM MOLECULAR TESTING David J. Pisapia, MD, Weill Cornell Medicine, New York, NY RC Conference Room 5 93

128 SPECIAL COURSES HOT TOPICS IN PATHOLOGY Hot Topics in Pathology Gastrointestinal Pathology MONDAY, MARCH 6, :00 PM 1:00 PM RC CONFERENCE ROOM 1-4 MODERATOR: PANELISTS: Rish K. Pai, MD, PhD, Mayo Clinic Arizona, Scottsdale, AZ Alyssa Krasinskas, MD, Emory University School of Medicine, Atlanta, GA Christophe Rosty, MD, PhD, Envoi Pathology Associates, Brisbane, Australia Gregory Lauwers, MD, University of California San Francisco, San Francisco, CA Amitabh Srivastava, MBBS, Brigham and Women s Hospital, Boston, MA Hot Topics in Pathology Breast Pathology TUESDAY, MARCH 7, :00 PM 1:00 PM RC CONFERENCE ROOM 1-4 MODERATOR: PANELISTS: Edi Brogi, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY Aysegul Sahin, MD, The University of Texas MD Anderson Cancer Center, Houston, TX Kalliopi P. Siziopikou, MD, PhD, Northwestern University Feinberg School of Medicine, Chicago, IL Melinda Sanders, MD, Vanderbilt University, Nashville, TN Hot Topics in Pathology Immunohistochemistry in Evaluating Tumors of Undetermined Origin WEDNESDAY, MARCH 8, :00 PM 1:00 PM RC CONFERENCE ROOM 1-4 MODERATOR: PANELISTS: Jason L. Hornick, MD, PhD, Harvard Medical School, Brigham & Women's Hospital, Boston, MA Andrew M. Bellizzi, MD, University of Iowa Carver College of Medicine, Iowa City, IA Allen M. Gown, MD, PhenoPath, Seattle, WA 94

129 SPECIAL COURSES HOT TOPICS IN PATHOLOGY Hot Topics in Pathology Dermatopathology THURSDAY, MARCH 9, :00 PM 1:00 PM RC CONFERENCE ROOM 1-4 MODERATOR: PANELISTS: Rajiv M. Patel, MD, University of Michigan, Ann Arbor, MI Victor G. Prieto, MD, PhD, MD Anderson Cancer Center, Houston, TX Richard Scolyer, Melanoma Institute Australia and Royal Prince Alfred Hospital, Camperdown, Australia Doru Andea, MD, MBA, University of Michigan, Ann Arbor, MI 95

130 SPECIAL COURSES SPECIAL LECTURES MONDAY MARCH 6 4:30PM - 5:30PM CONVENTION CENTER STARS AT NIGHT BALLROOM 2-4 NATHAN KAUFMAN TIMELY TOPICS LECTURE Platforms, Diagnosis and Disease: An Evolution Rooted in Pathology Daniel J. Brat, MD, PhD, Emory University School of Medicine, Atlanta, GA TUESDAY MARCH 7 4:15 PM - 5:50 PM CONVENTION CENTER STARS AT NIGHT BALLROOM 2-4 MAUDE ABBOTT LEGACY AND USCAP HONORS Prostate Cancer: Then and Now Peter A. Humphrey, MD, PhD, Yale University, New Haven, CT 96

131 LONG COURSE #IAMUSCAP #USCAP2017

132 Docs with Guts USCAP s GI pathologists are the conduit for precision learning. They will take you down the tube for a sensational educational experience that is enduring, contemporary and evocative. You can be your best because of the best. Learn more at

133 LONG COURSE LONG COURSE Prostate Pathology: Practical Issues WEDNESDAY, MARCH 8, :00 AM- 5:30 PM CC SNB 3&4 COURSE DIRECTOR: CO-DIRECTOR: Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH Ming Zhou, MD, PhD, New York University Medical Center, New York, NY COURSE DESCRIPTION: Accurate diagnosis, Gleason grading and staging of prostate cancer, and prudent use of ancillary tests are critical for management of prostate cancer patients. However, error in diagnosing, grading and reporting prostate cancer has remained a significant problem in clinical practice, with diagnostic errors that potentially impact clinical management in 1-15% of prostate biopsies. Gleason grading system has undergone significant modification and a new grading system has been proposed, yet the adoption of these changes in clinical practice is slow. New entities of important clinical significance, such as intraductal carcinoma, have been described. There have been tremendous advances in the understanding of molecular and genetic mechanisms in prostate carcinogenesis and progression which has led to development of multigene genetic and genomic tests. However, there has been a lack of understanding of the new entities and molecular diagnostic tests among practicing pathologists. Upon completion of this educational activity, participants should be able to: Review histological criteria for diagnosing prostate cancer and use of immunohistochemistry markers. Review benign mimickers of prostate cancer and cancer that mimics benign prostate lesions. Update on recent modifications of Gleason system and the novel grading system (grade grouping). Identify the clinical relevant pathological parameters that should be included in the surgical pathology report. Learn the new advances in molecular mechanisms in prostate carcinogenesis/progression and clinically relevant genetic tests. 8:00 AM WELCOME/INTRODUCTION Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH Ming Zhou, MD, PhD, NYU Medical Center, New York, NY 8:05 AM EPIDEMIOLOGY AND GENOMICS OF PROSTATE CANCER: AN UPDATE Mark Rubin, MD, Weill Cornell Medical College, New York, NY 8:30 AM PROSTATE CANCER: DIAGNOSTIC CRITERIA AND ROLE OF IMMUNOHISTOCHEMISTRY Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH 8:55 AM BENIGN MIMICKERS OF PROSTATE CANCER Kiril Trpkov, MD, University of Calgary, Calgary, AB 9:25 AM QUESTIONS 9:30 AM BREAK 10:30 AM PROSTATE CANCER GRADING: FROM GLEASON TO A CONTEMPORARY NEW GRADING SYSTEM Jonathan Epstein, MD, The Johns Hopkins Medical Institute, Baltimore, MD 11:00 AM UNUSUAL VARIANTS OF ACINAR PROSTATE CANCER MIMICKING BENIGN Peter A. Humphrey, MD, Yale University, New Haven, CT 11:25 AM PROSTATIC INTRAEPITHELIAL NEOPLASIA, INTRADUCTAL CARCINOMA, DUCTAL ADENOCARCINOMA AND PIN- LIKE DUCTAL ADENOCARCINOMA Ming Zhou, MD, PhD, New York University Medical Center, New York, NY 11:55 AM QUESTIONS 97

134 LONG COURSE Continued... LONG COURSE 12:00 PM LUNCH 1:00 PM MUCINOUS AND SECONDARY TUMORS OF THE PROSTATE Adeboye Osunkoya, MD, Emory University School of Medicine, Atlanta, GA 1:25 PM PROSTATE CANCER REPORTING AND STAGING David Grignon, MD, Indiana University School of Medicine, Indianapolis, IN 1:55 PM QUESTIONS 2:00 PM TREATMENT EFFECT IN PROSTATE CANCER Andy Evans, MD, PhD, Toronto General Hospital, Toronto, ON 2:25 PM NEUROENDOCRINE TUMORS OF THE PROSTATE Samson Fine, MD, Memorial Sloan Kettering Cancer Center, New York, NY 2:50 PM QUESTIONS 3:00 PM BREAK 4:15 PM MESENCHYMAL TUMORS OF PROSTATE Jesse McKenney, MD, Cleveland Clinic, Cleveland, OH 4:40 PM MARKERS OF CLINICAL UTILITY IN THE DIFFERENTIAL DIAGNOSIS AND PROGNOSIS OF PROSTATE CANCER Glen Kristiansen, MD, University of Bonn, Bonn, Germany 5:05 PM QUESTIONS 5:10 PM CLOSING REMARKS & WRAP-UP 98

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136 YOUR FORMULA FOR SUCCESS Short Courses offered this year, 4,296 attendees + Companion Meeting 7,009 attendees total 84 Countries represented 19 Evening Specialty Courses with 4,214 total attendees Long Course attendees Annual Meeting Attendance Attendees were from 84 countries other than the U.S. or Canada. Scientific abstracts were submitted 3054for evaluation Possible CME Per Person= 55.5 HOURS + + Possible SAMs Per Person= HOURS + Total Possible CME= 446 HOURS Total Possible SAMs= 302 HOURS = your Academy With an exceptional education track for trainees, networking receptions, a huge fellowship fair and trainee conference rates, the world s largest pathology meeting is the perfect place to advance your career.

137 SHORT COURSES SHORT COURSES - WEDNESDAY A COFFEE BREAK IS SCHEDULED FOR 9:30 AM 11:00 AM * Indicates this is a new course ++ Indicates this is an ending course WEDNESDAY, MARCH 8, :00 AM 12:00 PM Room locations are printed on the Short Course Ticket 02 MOLECULAR DIAGNOSTICS IN CYTOPATHOLOGY: OPPORTUNITIES, LIMITATIONS AND PITFALLS* Sinchita Roy-Chowdhuri, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX Michael Roh, MD, PhD, University of Michigan Health System, Ann Arbor, MI 06 DIAGNOSTIC DILEMMA IN NEOPLASTIC AND NON-NEOPLASTIC BONE PATHOLOGY John Reith, MD, UF Health, Shands Hospital, Gainesville, FL Gunnlauger Petur Nielsen, MD, Massachusetts General Hospital, Boston, MA Scott E. Kilpatrick, MD, Cleveland Clinic, Cleveland, OH 08 THE PATHOLOGIST S ROLE IN GUIDING BREAST CANCER TREATMENT IN THE ERA OF NEOADJUVANT THERAPY W. Fraser Symmans, MBChB, University of Texas MD Anderson Cancer Center, Houston, TX Elena Provenzano, MD, Addenbrookes Hospital, Cambridge, UK Veerle Bossuyt, MD, Yale School of Medicine, New Haven, CT 15 PRACTICAL OCULAR PATHOLOGY FOR PATHOLOGISTS++ Nora V. Laver, MD, Tufts Medical Center, Boston, MA Anat Stemmer-Rachamimov, MD, Massachusetts General Hospital, Boston, MA Charles S. Specht, MD, Penn State Hershey Medical Center, Hershey, PA 16 SURGICAL PATHOLOGY DIAGNOSTIC ERROR PREVENTION* Raouf E. Nakhleh, MD, Mayo Clinic, Jacksonville, FL Keith E. Volmar, MD, Rex Pathology Associates, Raleigh, NC 22 MAKING COMMENTS COUNT: HOW TO GIVE EFFECTIVE FEEDBACK* Richard A. Prayson, MD, Med, Cleveland Clinic, Cleveland, OH J. Jordi Rowe, MD, Cleveland Clinic, Cleveland, OH 36 THE UPDATED WHO CLASSIFICATION OF MYELOID NEOPLASMS: A PRACTICAL APPROACH TO GENETICALLY-DEFINED AND NOT-SO-WELL DEFINED ENTITIES* Attilio Orazi, MD, FRCPath, Weill Cornell Medical College/NYP, New York, NY Daniel A. Arber, MD, Stanford Medicine, Stanford Health Care, Stanford, CA Robert P. Hasserjian, MD, Massachusetts General Hospital, Boston, MA 38 COMMON DIAGNOSTIC DILEMMAS IN HEAD AND NECK PATHOLOGY: PITFALLS, PEARLS, AND CLINICAL INSIGHTS Qihui Jim Zhai, MD, Mayo Clinic, Jacksonville, FL John Casler, MD, Mayo Clinic, Jacksonville, FL 60 SURGICAL PATHOLOGY AND CYTOPATHOLOGY OF THE PANCREAS AND AMPULLA* N. Volkan Adsay, MD, Emory University Hospital, Atlanta, GA Olca Basturk, MD, Memorial Sloan Kettering Cancer Center, New York, NY Michelle Dian Reid, MD, Emory University School of Medicine, Atlanta, GA 99

138 SHORT COURSES SHORT COURSES - WEDNESDAY A COFFEE BREAK IS SCHEDULED FOR 3:00 PM 4:00 PM * Indicates this is a new course ++ Indicates this is an ending course WEDNESDAY, MARCH 8, :30 PM 5:30 PM Room locations are printed on the Short Course Ticket 07 IT S NOT AS BAD AS IT LOOKS: PAIRS OF LOOK-ALIKE LESIONS IN SURGICAL NEUROPATHOLOGY++ Bette K. Kleinschmidt-DeMasters, MD, University of Colorado, Aurora, CO Richard A. Prayson, MD, Med, Cleveland Clinic, Cleveland, OH 19 MELANOCYTIC LESIONS: A PRACTICAL APPROACH TO DIAGNOSIS, ADJUNCTIVE MOLECULAR STUDIES AND APPROPRIATE THERAPY/MANAGEMENT Martin C. Mihm, Jr., MD, Brigham & Women s Hospital, Boston, MA Richard A. Scolyer, MD, Royal Prince Alfred Hospital, Camperdown, Australia Adriano Piris, MD, Brigham & Women s Hospital, Boston, MA 23 SURGICAL AND MOLECULAR PATHOLOGY OF THYROID NEOPLASIA Thomas J. Giordano, MD, PhD, University of Michigan Health System, Ann Arbor, MI Bruce M. Wenig, MD, H. Lee Moffitt Cancer Center, Tampa, FL 31 DOING MORE WITH LESS: A CYTOLOGY-HISTOLOGY CORRELATION OF PULMONARY MASSES++ Jennifer Brainard, MD, Cleveland Clinic, Cleveland, OH Carol Farver, MD, Cleveland Clinic, Cleveland, OH 32 PREDICTIVE BIOMARKERS-LESSONS FROM CLINICAL TRIALS++ Sunil Badve, MD, Indiana University of Medicine, Indianapolis, IN Josef Rüschoff, MD, Targos Molecular Pathology GmbH., Kassel, Germany Reinhard Büttner, University Hospital of Cologne/Institute of Pathology, Germany 37 HEAD AND NECK PATHOLOGY IN THE HUMAN PAPILLOMAVIRUS ERA: A CRASH COURSE Bill Faquin, MD, PhD, Massachusetts General Hospital, Boston, MA Mitra Mehrad, MD, Vanderbilt University, Nashville, TN Justin Bishop, MD, The Johns Hopkins Medical Center, Baltimore, MD Rebecca Chernock, MD, Washington University School of Medicine, Saint Louis, MO 42 DIFFICULT DIAGNOSES IN PEDIATRIC HEMATOPATHOLOGY Michele E. Paessler, DO, Perelman School of Medicine Children s Hospital, Philadelphia, PA Dehua Wang, MD, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Robert Lorsbach, MD, PhD, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 48 PROBLEMATIC AREAS IN THE PATHOLOGY OF THE UTERINE CERVIX++ Esther Oliva, MD, Massachusetts General Hospital, Boston, MA Carmen Tornos, MD, Stony Brook School of Medicine, Stony Brook, NY 49 PRACTICAL APPROACH TO MOLECULAR DIAGNOSIS OF BONE AND SOFT TISSUE TUMORS* Judith V.M.G. Bovee, MD, PhD, Leiden University Medical Center, Leiden, Netherlands Adrian Marino-Enriquez, MD, Brigham & Women s Hospital, Boston, MA 100

139 SHORT COURSES SHORT COURSES - THURSDAY A COFFEE BREAK IS SCHEDULED FOR 9:30 AM 10:00 AM * Indicates this is a new course ++ Indicates this is an ending course THURSDAY, MARCH 9, :00 AM 11:30 AM Room locations are printed on the Short Course Ticket 04 AUTOPSY IN THE 21ST CENTURY: AN UPDATE FOR PATHOLOGISTS PERFORMING HOSPITAL AUTOPSIES TODAY Alex K. Williamson, MD, LIJ Medical Center/ Northwell Health, New Hyde Park, NY Jody E. Hooper, MD, The Johns Hopkins University, Baltimore, MD 05 THE NERVE OF SOME NERVE SHEATH TUMORS! A PRACTICAL APPROACH TO COMMON PROBLEMS IN SURGICAL PATHOLOGY Caterina Giannini, MD, PhD, Mayo Clinic, Rochester, MN Fausto J. Rodriguez, MD, The Johns Hopkins University, Baltimore, MD Arie Perry, MD, University of California San Francisco, San Francisco, CA Andrew L. Folpe, MD, Mayo Clinic, Rochester, MN 17 INTRODUCING THE WHO 2016 CLASSIFICATION OF TESTICULAR TUMORS: A SYNTHESIS OF MOLECULAR AND MORPHOLOGIC DATA* Daniel M. Berney, FRCPath, St. Bartholomew s Hospital, London, UK Muhammad T. Idrees, MD, Indiana University Medical Center, Indianapolis, IN 18 DIAGNOSTIC CRITERIA OF THE PARIS SYSTEM FOR REPORTING URINARY CYTOLOGY: AN OUTCOMES AND RISK BASED SYSTEM Mathew T. Olson, MD, The Johns Hopkins Hospital, Baltimore, MD Christopher VandenBussche, MD, PhD, The Johns Hopkins Hospital, Baltimore, MD Güliz A. Barkan, MD, Loyola University Healthcare System, Maywood, IL Eva M. Wojcik, MD, Loyola University Healthcare System, Maywood, IL 21 PRACTICAL MOLECULAR DIAGNOSTICS FOR THE PRACTICING SURGICAL PATHOLOGIST* Dr. Daniel Kurtycz, MD, University of Wisconsin, Madison, WI Laura J. Tafe, MD, Dartmouth-Hitchcock Medical Center, Lebanon, NH Maria E. Arcila, MD, Memorial Sloan Kettering Cancer Center, New York, NY 29 PRACTICAL ISSUES AND CLINICAL IMPLICATIONS IN URINARY BLADDER PATHOLOGY* Qihui Jim Zhai, MD, Mayo Clinic, Jacksonville, FL Jae Y. Ro, MD, PhD, Houston Methodist Hospital, Weill Medical College, Houston, TX 34 NON-INVASIVE NIGHTMARES IN BREAST PATHOLOGY++ Timothy W. Jacobs, MBChB, Virginia Mason Medical Center, Seattle, WA Yunn-Yi Chen, MD, PhD, University of California San Francisco, San Francisco, CA 43 MEDICAL LIVER BIOPSIES: TRANSLATING MORPHOLOGIC PATTERNS INTO MEANINGFUL PATHOLOGY REPORTS Michael Torbenson, MD, Mayo Clinic, Rochester, MN Sanjay Kakar, MD, University of California San Francisco, San Francisco, CA 44 SHEDDING LIGHT ON THE GRAY ZONES OF NEOPLASTIC LUNG PATHOLOGY* Lynette Sholl, MD, Brigham & Women s Hospital, Boston, MA Sanja Dacic, MD, PhD, University of Pittsburgh, Pittsburgh, PA Marina Vivero, MD, Brigham & Women s Hospital, Boston, MA 101

140 SHORT COURSES SHORT COURSES - THURSDAY CONTINUED... THURSDAY, MARCH 9, :00 AM 11:30 AM A COFFEE BREAK IS SCHEDULED FOR 9:30 AM 10:00 AM * Indicates this is a new course ++ Indicates this is an ending course 51 COMMON QUESTIONS IN GASTROINTESTINAL PATHOLOGY: PITFALLS AND PEARLS FROM DAILY CONSENSUS CONFERENCE* Deepa T. Patil, MD, Cleveland Clinic, Cleveland, OH Ana E. Bennett, MD, Cleveland Clinic, Cleveland, OH John R. Goldblum, MD, Cleveland Clinic, Cleveland, OH 53 FROM PIXELS TO DIAGNOSIS: INTRODUCTION TO DIGITAL PATHOLOGY AND IMAGE ANALYSIS* Anil Parwani, MD, PhD, The Ohio State University, Columbus, OH Metin Gurcan, PhD, The Ohio State University, Columbus, OH 54 PRACTICAL INFORMATICS SOLUTIONS FOR ANATOMIC PATHOLOGY QUALITY MANAGEMENT++ Jeffrey Prichard, DO, Geisinger Medical Center, Danville, PA Steven Meschter, MD, Geisinger Medical Center, Danville, PA 57 TRANSLOCATIONSS AND MUTATIONS AND REARRANGEMENTS, OH MY! THE PRACTICAL APPLICATION OF MOLECULAR TECHNIQUES IN GYNECOLOGIC PATHOLOGY* Debra A. Bell, MD, Mayo Clinic, Rochester, MN Sarah E. Kerr, MD, Mayo Clinic, Rochester, MN 102

141 SHORT COURSES SHORT COURSES - THURSDAY A COFFEE BREAK IS SCHEDULED FOR 2:30 PM 3:00 PM * Indicates this is a new course ++ Indicates this is an ending course THURSDAY, MARCH 9, :00 PM 4:30 PM Room locations are printed on the Short Course Ticket 03 USES AND LIMITATIONS OF IMMUNOHISTOCHEMISTRY AND OTHER ADJUNCTIVE STUDIES IN BREAST PATHOLOGY Stuart J. Schnitt, MD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Laura C. Collins, MD, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 09 CHALLENGING FROZEN SECTIONS: WHEN DO I STICK MY NECK OUT AND HOW FAR?* Rhonda K. Yantiss, MD, Weill Cornell Medical College, New York, NY Timothy D Alfonso, MD, Weill Cornell Medical College, New York, NY Theresa Scognamiglio, MD, New York Presbyterian Hospital, New York, NY Brian Robinson, MD, Weill Cornell Medical College, New York, NY Alain Borczuk, MD, Cornell University Medical Center, New York, NY 11 CONTEMPORARY CARDIOVASCULAR PATHOLOGY FROM GROSSING BENCH TO BEDSIDE: HOW EMERGING ANCILLARY TOOLS ARE TRANSFORMING THE FIELD Joseph J. Maleszewski, MD, Mayo Clinic, Rochester, MN Peter T. Lin, MD, Mayo Clinic, Rochester, MN 24 BACTERIAL INFECTION AND THE KIDNEY: DIAGNOSTIC DIFFICULTIES IN KIDNEY BIOPSIES++ Anjali A. Satoskar, MD, The Ohio State University, Columbus, OH Tibor Nadasdy, MD, PhD, The Ohio State University, Columbus, OH 25 COLORECTAL DYSPLASIA IN IBD: DIAGNOSIS, IMPLICATIONS, AND PITFALLS Alexandros D. Polydorides, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, NY Noam Harpaz, MD, Mt. Sinai Medical Center, New York, NY Steven Itzkowitz, MD, Mt. Sinai School of Medicine, New York, NY 27 A PATTERN-BASED APPROACH TO THE DIAGNOSIS OF SOFT TISSUE TUMORS++ Leona A. Doyle, MD, Brigham & Women s Hospital, Boston, MA Jason L. Hornick, MD, PhD, Brigham & Women s Hospital, Boston, MA 30 DIAGNOSIS OF RENAL NEOPLASMS USING INTEGRATED HISTOLOGIC, CYTOLOGIC AND MOLECULAR APPROACHES IN THE ERA OF PRECISION MEDICINE Christopher Przybycin, MD, Cleveland Clinic, Cleveland, OH Jordan Reynolds, MD, Cleveland Clinic, Cleveland, OH Ming Zhou, MD, PhD, New York University Medical Center, New York, NY 39 BONE MARROW MANIFESTATIONS OF SYSTEMIC DISEASE Dita Gratzinger, MD, PhD, Stanford University Medical Center, Stanford, CA David Czuchlewski, MD, University of New Mexico School of Medicine, Albuquerque, NM Tracy George, MD, University of New Mexico School of Medicine, Albuquerque, NM 52 DIFFICULT ENDOMETRIAL BIOPSIES: MALIGNANCY, MIMICS, MOLECULES, AND MISHAPS++ Bojana Djordjevic, MD, University of Ottawa, Ottawa, ON Anais Malpica, MD, University of Texas MD Anderson Cancer Center, Houston, TX Russell Broaddus, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX 55 A PRACTICAL APPROACH TO INFECTIOUS DISEASE PATHOLOGY++ Bobbi S. Pritt, MD, Mayo Clinic, Rochester, MN Laura W. Lamps, MD, University of Michigan, Ann Arbor, MI 103

142 SHORT COURSES SHORT COURSES - THURSDAY CONTINUED... THURSDAY, MARCH 9, :00 PM 4:30 PM A COFFEE BREAK IS SCHEDULED FOR 2:30 PM 3:00 PM * Indicates this is a new course ++ Indicates this is an ending course 56 NERVE AND MUSCLE BIOPSIES- A PATIENT-CENTERED APPROACH FOR THE GENERAL PATHOLOGIST Peter Pytel, MD, The University of Chicago Medicine, Chicago, IL Douglas Anthony, MD, Rhode Island Hospital, Providence, RI 59 OCCUPATIONALLY RELATED PLEURAL AND PULMONARY DISORDERS IN THE 21ST CENTURY: CHALLENGES, PITFALLS AND NO-NOS Victor Roggli, MD, Duke University Medical Center, Durham, NC Thomas A. Sporn, MD, Duke University Medical Center, Durham, NC Henry D. Tazelaar, MD, Mayo Clinic, Scottsdale, AZ 62 NODAL METASTASES IN HEAD AND NECK LESIONS: WHERE S THE PRIMARY?* Bruce Wenig, MD, H. Lee Moffitt Cancer Center, Tampa, FL Juan C. Hernandez-Prera, MD, H. Lee Moffitt Cancer Center, Tampa, FL 104

143 SHORT COURSES SHORT COURSES - FRIDAY A COFFEE BREAK IS SCHEDULED FOR 9:30 AM 10:00 AM * Indicates this is a new course ++ Indicates this is an ending course FRIDAY, MARCH 10, :00 AM 11:30 AM Room locations are printed on the Short Course Ticket 12 MEDICAL RENAL PATHOLOGY FOR THE GENERAL SURGICAL PATHOLOGIST++ Anthony Chang, MD, University of Chicago, Chicago, IL Vanesa Bijol, MD, Brigham & Women s Hospital, Boston, MA 14 BIOPSIES OF MEDIASTINAL LESIONS: CHALLENGES, PITFALLS AND PRACTICAL TIPS++ Anja C. Roden, MD, Mayo Clinic, Rochester, MN Jennifer M. Boland, MD, Mayo Clinic, Rochester, MN Marie Christine Aubry, MD, Mayo Clinic, Rochester, MN 20 CHALLENGES IN THYROID CYTOPATHOLOGY: HOW CAN ULTRASOUND FINDINGS AND MOLECULAR TESTS HELP?++ Helen H. Wang, MD, Beth Israel Deaconess Medical Center, Boston, MA Pamela Hartzband, MD, Beth Israel Deaconess Medical Center, Boston, MA Michiya Nishino, MD, PhD, Beth Israel Deaconess Medical Center, Boston, MA 26 COLONIC POLYPS-DAILY PROBLEMS ONLY PATHOLOGISTS UNDERSTAND David F. Schaeffer, MD, Vancouver General Hospital, Vancouver, BC Hector Li-Chang, MD, Royal Victoria Regional Health Centre, Barrie, ON Rish K. Pai, MD, PhD, Mayo Clinic Arizona, Scottsdale, AZ 35 GOING WITH THE FLOW OF BILE: AN UPDATE ON TUMORS OF THE LIVER, BILE DUCTS AND GALLBLADDER++ N. Volkan Adsay, MD, Emory University Hospital, Atlanta, GA Alyssa M. Krasinskas, MD, Emory University Hospital, Atlanta, GA Matthew M. Yeh, MD, PhD, University of Washington Medical Center, Seattle, WA 40 HEMATOLYMPHOID LESIONS AT THE BORDERLINE BETWEEN BENIGN AND MALIGNANT-FINDING YOUR WAY OUT OF UNCERTAINTY Eric Hsi, MD, Cleveland Clinic, Cleveland, OH Carlos E. Bueso-Ramos, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX Megan O. Nakashima, MD, Cleveland Clinic, Cleveland, OH 41 EXPANDING THE DIFFERENTIAL DIAGNOSIS IN UROLOGIC PATHOLOGY: CONTROVERSIES AND NEW ENTITIES++ Michelle Hirsch, MD, PhD, Brigham & Women s Hospital, Boston, MA Donna E. Hansel, MD, PhD, University of California, San Diego, La Jolla, CA Mahul B. Amin, MD, Cedars-Sinai Medical Center, West Hollywood, CA 47 LATE INTRAUTERINE DEMISE: PLACENTAL AND FETAL POSTMORTEM PATHOLOGY++ Theonia K. Boyd, MD, Children s Hospital Boston, Boston, MA Drucilla J. Roberts, MD, Massachusetts General Hospital, Boston, MA 50 CLINICAL REALITIES OF NEXT-GENERATION SEQUENCING John D. Pfeifer, MD, PhD, Washington University, Saint Louis, MO Nikoletta Sidiropoulos, MD, The University of Vermont, Burlington, VT Jennifer Sehn, MD, Washington University, Saint Louis, MO Eric Duncavage, MD, Washington University, Saint Louis, MO 105

144 SHORT COURSES SHORT COURSES - FRIDAY A COFFEE BREAK IS SCHEDULED FOR 2:30 PM 3:00 PM * Indicates this is a new course ++ Indicates this is an ending course FRIDAY, MARCH 10, :00 PM 4:30 PM Room locations are printed on the Short Course Ticket 10 DIAGNOSTIC CHALLENGES IN PROSTATE PATHOLOGY++ Adeboye O. Osunkoya, MD, Emory University School of Medicine, Atlanta, GA Cristina Magi-Galluzzi, MD, PhD, Cleveland Clinic, Cleveland, OH 28 PULMONARY INFECTIONS: MORPHOLOGIC AND MOLECULAR TIPS FOR THE SURGICAL PATHOLOGIST++ Sanjay Mukhopadhyay, MD, Cleveland Clinic, Cleveland, OH Gary Procop, MD, Cleveland Clinic, Cleveland, OH Carol Farver, MD, Cleveland Clinic, Cleveland, OH 33 OVARIAN CARCINOMA: AN UPDATE ON HISTOTYPE DIAGNOSIS, PRIMARY SITE ASSIGNMENT, AND STAGING C. Blake Gilks, MD, Vancouver General Hospital, Vancouver, BC Martin Köbel, MD, Calgary Laboratory Services, Calgary, AB Naveena Singh, MD, The London Clinic, London, UK 45 WORKSHOP ON PROBLEMATIC DUCTAL PROLIFERATIONS OF THE BREAST++ Melinda F. Lerwill, MD, Massachusetts General Hospital, Boston, MA Kimberly Allison, MD, Stanford University, Stanford, CA Kristin Jensen, MD, MD, FCAP, Stanford University, Stanford, CA 46 OPEN CONFESSION IS GOOD FOR THE SOUL: MEMORABLE MISTAKES AND WHAT WE VE LEARNED++ Rhonda K. Yantiss, MD, Weill Cornell Medical Center, New York, NY Laura W. Lamps, MD, University of Michigan, Ann Arbor, MI 106

145 SPECIAL LECTURES #IAMUSCAP #USCAP2017

146 The Presidents Helix Ferrell Fuller Zarbo Crum Asa LiVolsi DeLellis Jaffe Kempson Powers Schnitt Reuter Appelman Lloyd Dehner Powell Weiss Hardwick Goldblum Every Generation Sequencing Revival. Continuity. Perspective. Engagement. Vitality. Legacy. Past-Presidents of the United States and Canadian Academy of Pathology may have completed their official tenures and leadership contributions, but represent a continuous source of institutional memory, wisdom, and contemporary, imaginative ideas. These iconic leaders have been invited to revive their engagement with the Academy through the helix, which passes USCAP DNA through generations of leadership to the future executive lineage. Through this identity, Past-Presidents may serve as advisors to current leadership, Ambassadors, and Strategic Planning, give courses in the Powers-Sanchez Interactive Center, and engage in media outreach to promote international development of the Academy. They are the structural backbone of an organization still in its growth spurt.

147 THE MAUDE ABBOTT LECTURE PETER A. HUMPHREY, M.D., PH.D USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Dr. Peter A. Humphrey is a surgical pathologist with expertise in urologic and prostate pathology. He was born in Chicago, Illinois and earned his B.A. from the University of Kansas, where he majored in chemistry and biochemistry. In 1984 he received his M.D. degree and Ph.D. degree (in biochemistry) from the University of Kansas Medical Center, followed by anatomic pathology residency at Duke University Medical Center. During the middle of his residency he took 2 research years to work on epidermal growth factor receptor (EGFR) mutant proteins and was awarded, at a USCAP meeting, the Benjamin Castleman Award for the work, published in PNAS, on creation of an antibody specific for a deletion mutant EGFR protein expressed in glioblastomas. During residency at Duke he launched his career-long interest in urologic pathology and prostate cancer, at a time when there was a surge of national clinical interest in prostate cancer with the introduction of prostate-specific antigen (PSA) testing and more widespread utilization of radical prostatectomy. In December 1988, he joined the faculty at Duke as Assistant Professor of Pathology and in 1992 left to become Associate Professor at Washington University School of Medicine in St. Louis, where he became Full Professor and in 2006 was named the Ladenson Professor and Director of Anatomic and Molecular Pathology. In 2014 he joined the Yale School of Medicine Department of Pathology as Professor and Director of Genitourinary Pathology. Dr. Humphrey has published over 330 papers, reviews, and book chapters, with a dominant focus on genitourinary pathology and diseases of the prostate. He is sole author of the 2003 textbook Prostate Pathology, is co-author of the 2011 AFIP Fascicle on Tumors of the Prostate, is editor and co-author of the 2008 and 2012 editions of The Washington Manual of Surgical Pathology, is co-author of the 2014 textbook Neoplastic Mimics in Genitourinary Pathology, and is a volume editor and co-author of the 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs. He has lectured and given courses throughout the United States and world, including 6 of the 7 continents (with only Antarctica to go). His prostate research includes clinico-pathologic and molecular pathologic studies. Molecular pathologic studies led to publications on the role of hepatocyte growth factor (scatter factor) and its receptor, c-met in prostate cancer, and separate papers on gene expression profiling of prostatic atrophy, ductal adenocarcinoma of the prostate, and acinar prostate cancer. Surgical pathology investigations include an original description of pseudohyperplastic adenocarcinoma and characterization of additional deceptively benign appearing prostate cancers including microcystic, foamy, and atrophic adenocarcinomas. Additional papers have addressed diagnostic immunohistochemistry, prostatic intraepithelial neoplasia, screen-detected prostate cancers, and prognostic indicators of tumor extent and grade. Teaching/ medical education is a vital component of Dr. Humphrey s career. He feels fortunate to have had the opportunity to provide many courses and lectures in many different venues. He also feels privileged to have worked with so many bright residents and fellows over the years. He has won resident teaching awards at Duke University and Washington University. Dr. Humphrey first attended a United States and Canadian Academy of Pathology (USCAP) Annual Meeting as a resident and has attended and contributed to every USCAP Annual Meeting since He has served as member of the Nominating Committee, member of Council, member of the Abstract Review, and member of the Education Committee. He has been moderator of numerous platform sessions, has helped give two short courses, and co-directed the 2003 Long Course on Prostate. The United States and Canadian Academy of Pathology has been crucial in Dr. Humphrey s career development. He is honored to provide the 2017 Maude Abbott Lecture. 107

148 USCAP is all around you. Take it in. Propose a Short Course Assist in USCAP's global educational outreach Join a USCAP Committee Instruct an Interactive Microscopy Course Guide the growth of your Academy Create an Academy buzz on social media Help attract USCAP members for life Reach out to pathologists-intraining Support the USCAP Foundation N. Volkan Adsay, M.D. USCAP President Engage with your Academy with a voice in next generation learning:

149 THE NATHAN KAUFMAN TIMELY TOPICS LECTURE DANIEL J. BRAT, M.D., PH.D USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Dr. Brat received his M.D. and Ph.D. from the Mayo Medical and Graduate Schools and then completed Residency in Anatomic Pathology and a Fellowship in Neuropathology at Johns Hopkins Hospital. He joined the Department of Pathology and Laboratory Medicine at Emory University in 1999 and is now a Professor and Vice Chair of Translational Programs. Dr. Brat is certified in Anatomic and Neuropathology and the Director of Neuropathology at Emory Healthcare Hospitals, where his practice includes Surgical and Autopsy Neuropathology. He has co-authored two textbooks in Neuropathology: Practical Surgical Neuropathology: A Diagnostic Approach, and Biopsy Interpretation of Central Nervous System. He has been involved with the WHO Classification of Brain Tumors since 2000 and co-authored 9 chapters in the 2016 edition. He has been the Co-Director of the AP/CP Residency Program for 11 years and the Director of the Neuropathology Fellowship Program for 16 years and has overseen the clinical training of over a 100 residents and fellows in Surgical Neuropathology. He has also participated in over 50 CME courses nationally and internationally, including Short Courses, Evening Sessions, and Companion Sessions at USCAP. Dr. Brat directs an NIH-funded basic and translational research laboratory that investigates mechanisms of glioma progression, including the contributions of hypoxia, genetics, tumor microenvironment and stem cells. He leads the scientific efforts of the In Silico Center for Brain Tumor Research, which uses large scale clinical and molecular databases, such as The Cancer Genome Atlas (TCGA), to address fundamental questions in human glioma behavior. He is also the Director of the NCIsupported Cancer Tissue and Pathology Shared Resource at Winship, which includes a full service histology laboratory and tissue procurement service. He has over 17 years of experience in brain tumor research and has written more than 200 peerreviewed manuscripts and reviews. In the laboratory setting, he has trained and mentored over 50 students, residents and fellows and has been named Mentor of the Year for Postdoctoral training at Emory University. Dr. Brat has served in leadership positions that oversee clinical practice and investigation in Oncology and Pathology, including the TCGA Glioblastoma and Lower Grade Gliomas (Co-Chair) Working Groups; the College of American Pathologists (CAP) Neuropathology Committee (Chair) and Council on Scientific Affairs; the Executive Council and Vice President Elect of the American Association of Neuropathologists; the of Directors for the Society of Neuro-oncology; the WHO Committee for Classification of Brain Tumors; and the AJCC Expert Panel. He is a member of the American Society for Clinical Investigation. 109

150 USCAP AMBASSADORS: TAKING OUTREACH TO NEXT GENERATION CONNECTIVITY COUNTRIES REPRESENTED AFGHANISTAN ALGERIA ARGENTINA BOTSWANA BRAZIL CANADA CROATIA HAITI INDIA JAPAN MYANMAR NEPAL NIGERIA PAKISTAN REPUBLIC OF MOLDOVA RWANDA SINGAPORE TURKEY UGANDA UK USA The re-imagined Ambassador Program is designed to achieve connectivity with future generations of pathologists. Engagement of pathologists-in-training as members for life in USCAP is critical to their career development and to becoming better pathologists. Ambassadors function to communicate to pathologists-in-training the value of membership in USCAP, engaging their interest, participation, and loyalty. The educators, committee members/chairs, and governance of USCAP derive from committed pathologists-in-training whose evolving maturity leads to the experience and confidence to assume these active roles. USCAP AMBASSADORS (DOMESTIC) 111 (36 STATES) USCAP AMBASSADORS (INTERNATIONAL) 24 (19 COUNTRIES) For more information or to apply for Ambassadorship, please contact us USCAP West 500 South Palm Canyon Drive, Suite 321 Palm Springs, CA Phone Fax

151 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY RESONATES WITH EXCELLENCE. WE ARE PROUD TO INTRODUCE THESE AWARD RECIPIENTS WHO HAVE MADE OUTSTANDING CONTRIBUTIONS IN THE FIELD OF PATHOLOGY.

152 THRIVE! Mentoring is a relationship in which someone helps another to evolve. It s based on sharing expertise and knowledge, with powerful influence on career development. This Certificate of Appreciation recognizes YOUR MENTOR S NAME HERE for helping YOUR NAME HERE to become a better pathologist. USCAP Foundation will help you honor the mentor who helped you achieve your goals. Honor Your Mentor. For each $100 donation you make, USCAP Foundation will send a certificate of appreciation to the mentor of your choice. The funds raised will be used to pay it forward by helping pathologists-in-training attend the USCAP Annual Meeting. This year, USCAP Foundation is providing $15,000 in travel expenses for pathologists-in-training to attend the 2017 Annual Meeting. You can honor your mentor and help foster the next generation of pathologists all at once! For more information visit: foundation.uscap.org/mentor2017

153 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Knowledge is at the Center of Acknowledgement USCAP honors superior performance in teaching, research, publications, and service by recognizing vision, imagination and intuitive leadership. The Academy builds its future on high performers, the gatekeepers of its structural foundation. s Distinguished Pathologist Award The s Distinguished Pathologist Award was established by the USCAP of Directors for recognition of distinguished service in the development of the discipline of pathology. This award is presented to an individual who is recognized for making major contributions to pathology over the years. The F.K. Mostofi Distinguished Service Award The F.K. Mostofi Distinguished Service Award was established in 1976 as a tribute to the long and distinguished service to the Academy given by Dr. Mostofi. The award may be presented annually to a member of the Academy who has emulated Dr. Mostofi with outstanding service to USCAP and to the International Academy of Pathology. The President s Award This award was established so that each year the President and the Executive Committee would have the opportunity to recognize an individual for outstanding service to the Academy and the field of pathology. Harvey Goldman Master Teacher of the Year Award The Harvey Goldman Master Teacher of the Year Award was established in 2011 as a tribute to honor a dedicated, longstanding educator and mentor, Dr. Harvey Goldman. This award recognizes Dr. Goldman s seminal contributions to the USCAP s postgraduate educational and mentoring activities. Ramzi S. Cotran Young Investigator s Award The Ramzi S. Cotran Young Investigator s Award was established by the USCAP of Directors to recognize a body of investigative work which has contributed significantly to the diagnosis and understanding of human disease. This important award is named after Dr. Ramzi S. Cotran, Past-President of USCAP, outstanding pathologist, person, and mentor. Benjamin Castleman Award The Benjamin Castleman Award is presented during the USCAP Annual Meeting for an outstanding paper in the field of human pathology published in English during the preceding calendar year. F. Stephen Vogel Award The F. Stephen Vogel Award was established by contributions to a fund created by his family and friends. It is to be awarded in recognition of an outstanding paper by a resident or fellow published in one of the Academy journals, Modern Pathology or Laboratory Investigation, during the preceding calendar year. Dr. L. Clarke Jr. and Elaine F. Stout Endowment Award The Dr. L. Clarke Jr. and Elaine F. Stout Endowment Award was established in 2015 by the generous support of Dr. L. Clarke Jr. and Elaine F. Stout. This award ensures that pathologists endeavoring to resolve scientific medical problems by studying anatomic features are supported and appreciated in perpetuity. Florabel G. Mullick Award The Florabel G. Mullick Award honors the memory and enduring contribution of an inspirational pathologist who served as the first civilian director of the AFIP (Armed Forces Institute of Pathology). Stowell-Orbison, Surgical Pathology and Autopsy Awards for Pathologists-in-Training Pathologists-in-training (residents, fellows, Ph.D. candidates or medical students) who are first authors of a scientific paper presented at the USCAP Annual Meeting are eligible to apply for these awards. 1

154 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT BOARD S DISTINGUISHED PATHOLOGIST AWARD CHRISTOPHER D.M. FLETCHER, M.D., FRCPath Dr. Fletcher graduated from St. Thomas Hospital Medical School in London and obtained postgraduate qualifications from the Royal College of Pathologists (MRCPath ) and the University of London (M.D ) in the United Kingdom. Dr. Fletcher has published extensively on the pathology of soft tissue tumors and is probably best known for his work challenging the diagnostic entities of malignant fibrous histiocytoma and hemangiopericytoma. He has also described for the first time a variety of lesions, including, among others, deep benign fibrous histiocytoma, angiomyofibroblastoma, retiform hemangioendothelioma, spindle cell liposarcoma, myoepithelial lesions of soft tissue, cellular angiofibroma and soft tissue angiofibroma. He has worked extensively on cytogenetic/morphologic correlations in soft tissue tumors. He is Chairman of the WHO Working Group on the Classification of Soft Tissue Tumours, having been senior editor of both the 2002 and most recent 2013 classifications. He has nearly 600 publications, including more than 400 original papers on soft tissue neoplasms, and several books, among which are the two-volume Diagnostic Histopathology of Tumors, now in its 4th edition. He has been the recipient of numerous honors and awards, is on the editorial board of 17 international journals and was President of the Association of Directors of Anatomic and Surgical Pathology from He is currently President-Elect of USCAP and is former President of the International Society of Bone & Soft Tissue Pathology and the Arthur Purdy Stout Society. Dr. Fletcher is currently Professor of Pathology at Harvard Medical School, Vice Chair, Anatomic Pathology at Brigham and Women s Hospital, Boston, Massachusetts and Chief of Onco- Pathology at the Dana-Farber Cancer Institute in Boston. 2

155 THE F.K. MOSTOFI DISTINGUISHED SERVICE AWARD JOHN H. SINARD, M.D., Ph.D USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Dr. John Sinard did his undergraduate training in Biochemical Sciences at Harvard, and then obtained M.D. and Ph.D. degrees from the Johns Hopkins University School of Medicine. Subsequently, he did an Anatomic Pathology residency at the Yale New Haven Medical Center, and then joined the faculty in the department of Pathology at Yale where he has been since, rising to the rank of Professor. His first book, Outlines in Pathology, has been used by residents for many years to prepare for the American of Pathology examination. As one of the early pioneers in pathology informatics, his second book, Practical Pathology Informatics, was the first book devoted to informatics in the practice of anatomic pathology. During his time at Yale, John directed the Autopsy Service for 16 years and the Residency Training program for 6 years. He founded and is currently the medical director of the Pathology Informatics program at Yale, which is well known for developing custom software for clinical use, with a particular focus on solutions to improve the clinical workflow in anatomic pathology. This includes barcode-based asset tracking in histology, frozen section management and communication with the operating rooms, an integrated pathologist s workstation, a synoptic reporting module with automated staging, and quality and patient safety tools. He is currently the Vice Chair and Director of Anatomic Pathology. He remains clinically active in both surgical pathology and autopsy pathology, and still directs the ophthalmic pathology service, holding a joint appointment in the Department of Ophthalmology and Visual Sciences. He serves on the Medical Records and Clinical Information Committee, the Perioperative Patient Safety and Quality Committee, and the Medical Leadership Council for Yale-New Haven Hospital. He is Vice Chair of the State of Connecticut s Commission on Medicolegal Investigations. For USCAP, John taught the first short course on pathology informatics ( Managing and Using Clinical Information Systems in Anatomic Pathology ) from , and the second ( Practical Pathology Informatics: The Basics ) every other year from He served on the Education Committee for seven years and the Innovative Educational Products Committee for five years. In 2006 he became the founding Editor-in-Chief and CEO of the eacademy, the on-line education arm of USCAP, for which he designed and helped implement the Anatomic Pathology Electronic Case Series (APECS) program. He was elected to the of Directors in 2012, and became the first Secretary for the Academy under the new governance structure in John also serves on multiple committees and councils for the College of American Pathologists. He has served on the Hematology and Pathology Devices Panel of the Center for Devices and Radiological Health at the United States Food and Drug Administration, and is a member of the Clinical Laboratory Improvement Advisory Committee for the Centers for Disease Control. Personally, it has been an honor working for and with the United States and Canadian Academy of Pathology and its members. This is an amazing group of dedicated individuals devoted to the ongoing education of pathologists at all levels of their careers. I would particularly like to recognize two individuals who gave me the opportunity to get involved with USCAP early in my career, namely Fred Silva, then Executive Vice President of the USCAP, and Jeffrey Myers, then Chair of the USCAP Education Committee. They opened the door for what has been a wonderful two decades of involvement with the leadership of USCAP. Dr. Sinard will continue for a second term as Secretary of USCAP. 3

156 THE PRESIDENT'S AWARD USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT LAURA W. LAMPS, M.D Dr. Laura Webb Lamps is Professor of Pathology and Vice Chair for Academic Affairs at the University of Arkansas for Medical Sciences. Dr. Lamps, originally from Auburn, Alabama, received her B.S. degree from Davidson College, followed by her M.D. from Vanderbilt University in She also completed her residency and surgical pathology fellowship training at Vanderbilt. She joined the faculty at the University of Arkansas for Medical Sciences (UAMS) in 1998, where she most recently held the position of Professor and Vice Chair for Academic Affairs. In February of 2017, Dr. Lamps joined the faculty of the University of Michigan Department of Pathology as the Godfrey D. Stobbe Professor of Gastrointestinal Pathology, and Patient Safety Officer for the University of Michigan Hospital. Dr. Lamps is a renowned academic pathologist and educator, and a leader in the fields of gastrointestinal, hepatic, and infectious disease pathology. She has received multiple teaching awards, including the UAMS Department of Pathology Teaching Award, the UAMS Dean s Resident Teaching Award, and the UAMS Dean s Educational Incentive Award. She was recognized at graduation seven times by the UAMS fourth year medical students for her contributions to education. She has been invited as a visiting professor or course faculty at over 60 institutions throughout the country and the world. She has authored numerous papers and abstracts, particularly in her primary area of interest, the study of infectious diseases of the liver and GI tract. She is the co-author or author of several major pathology textbooks including Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections; Diagnostic Pathology: Normal Histology; and Diagnostic Pathology: GI Endoscopic Correlation. She has also contributed numerous book chapters to texts including Odze and Goldblum s Surgical Pathology of the Gastrointestinal Tract, Liver, Biliary Tract, and Pancreas, which is regarded as the most widely used GI textbook in the world. She is also one of four editors of the upcoming new edition of Rosai and Ackerman s Surgical Pathology. Dr. Lamps has served USCAP in many capacities. She has been a member of the Vogel Award Committee, the Ramzi Cotran Young Investigator Award Committee, and was co-chair of the Residency Advisory Committee. She was a member of the USCAP Council (now ) from , and most recently served as the chair of the Education Committee. During her tenure as chair of the Education Committee, she worked on several important initiatives including an overhaul of the evaluation system and creation of a procedure manual that documents all of the policies and procedures of the committee. Dr. Lamps has recently moved to Ann Arbor with her husband, Paul Ward, and their two rescue corgis, Henry and Alys. She is active in animal welfare efforts, and served on the board and as the past President of the Central Arkansas Rescue Effort for Animals. She is an avid knitter, cook, and substitute yoga instructor. 4

157 HARVEY GOLDMAN MASTER TEACHER OF THE YEAR AWARD STEVEN H. SWERDLOW, M.D USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Dr. Steven Swerdlow recognized his destiny at a young age. A workbook page entitled My Plans for the Future drawn in third grade shows him seated looking through a microscope with a pair of glasses and a mouse in a cage at his side! A graduate of Brandeis University and Harvard Medical School, he did his AP/CP training at Beth Israel Hospital in Boston, followed by a hematopathology fellowship with R. D. Collins and then a research fellowship at St. Bartholomew s Hospital in London. After nine years at the University of Cincinnati, he joined the University of Pittsburgh where he is Professor of Pathology and Hematopathology Division Director. Dr. Swerdlow is an accomplished hematopathologist and dedicated educator. His clinical work has been recognized with inclusion in America s Top Doctors and Best Doctors in America. His investigative efforts have concentrated on B-cell lymphomas (eg, with M. Williams helped establish the genetic basis of mantle cell (centrocytic) lymphoma), and to a lesser extent on T/NK-cell neoplasms, cutaneous lymphomas and the post-transplant lymphoproliferative disorders. He was involved in developing the WHO-EORTC classification of cutaneous lymphomas, lead editor for the 2008 WHO monograph on Classification of Tumours of Haematopoietic and Lymphoid Tissues and is lead editor for the 2016/2017 revision. He has >200 peer-reviewed publications, and published numerous chapters, a lymph node pathology text, and co-edited a pediatric hematopathology text. These accomplishments have led to many invited lectures around the world and the inaugural Society for Hematopathology (SH) Berard-Dorfman Founders Award for a senior hematopathologist (2015). He is an American of Pathology trustee, an ACGME Pathology Review Committee member; and, former USCAP council member, SH President, EAHP Executive Committee member, and Pittsburgh Pathology Society President. His lectures are known for their educational content, visual interest and entertaining qualities. He has received three resident teaching awards and has provided courses, helped organize slide workshops and provided other educational and special lectures for the USCAP (5 short courses, 2 long courses including one as co-director, and Diagnostic Pathology faculty) and numerous other organizations/institutions. He is grateful to the USCAP for its critical role in promoting his career. Of those from the old days, only Carolyn Lane remains, but Jo Ann Johnson, Jim Crimmins, and Fred Silva will never be forgotten. This award is of particular significance to Dr. Swerdlow because of his personal connection to Dr. Harvey Goldman admiring him as a teacher in medical school, and as an important mentor during his residency. Although he knows he drove Dr. Goldman crazy since he was unable to keep up a conversation about the Boston Red Sox while signing out together over the summer, he remained a friend until the end. Dr. Goldman, along with Dr. Donald Antonioli, worked with Dr. Swerdlow on his first classification project, one related to dead bowels, not lymphomas. Receiving this award would have pleased Dr. Swerdlow s father, an academic pathologist and winner of multiple Golden Apple teaching awards, and is a source of joy for his 92-year-old mother. Finally, he is grateful for the support of his wife Jenny, daughters Debbie (son-in-law Scott and granddaughter Mia) and Naomi. Many years ago, Naomi wrote that If you don t know what slides are, they have a picture on it and you put one in a thing you turn on the fwockis[sic] and look throw[sic] and see a neat picture and Debbie that The job of being a pathologist (a kind of doctor) is quite hard. Like most doctors, they try to cure people. Nothing more needs to be said. 5

158 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT THE RAMZI S. COTRAN YOUNG INVESTIGATOR S AWARD ANTHONY J. GILL, MBBS, FRCPA, M.D. Dr. Anthony Gill was born at Royal North Shore Hospital in Sydney in the old maternity unit, not more than 20 meters from the location of his current office and laboratory. He attended the Shore School on a full academic scholarship where he was dux and prefect before progressing to fulfilling his childhood dream to study medicine (MBBS) at the University of Sydney. He graduated with the Royal North Shore Hospital Medal and prizes for first in the university in both Medicine and Surgery in His postgraduate training included clinical years as an intern, resident and registrar in both internal medicine and emergency. Almost on a whim in 2000 he commenced training in the dark arts of Anatomical Pathology at Royal North Shore Hospital under the tutelage of pathologists whom he greatly respects including Judith Fryer, Jeanette Philips and Roberts Eckstein. He was immediately entranced by the ability of dedicated and highly trained pathologists to make critical decisions and directly and dramatically help patients on a daily basis, often despite minimal community recognition. During his training he had the opportunity to learn at Royal Prince Alfred Hospital, the Children s Hospital Westmead and the NSW Institute of Forensic Medicine. He qualified FRCPA in 2005 and commenced practice as a staff specialist at Royal North Shore Hospital with special interest in endocrine, gastrointestinal and pancreaticobiliary pathology. He also commenced translational research in surgical pathology gravitating towards the areas of endocrine and pancreaticobiliary pathology primarily because it was in these areas that he encountered particularly passionate and dedicated clinical and laboratory teams. He was awarded a higher doctorate by publication by the University of Sydney in 2011 and promoted to Associate Professor in Seeing a strong need for pathologists to not just contribute to translational research in clinical fields and the basic sciences, but also to be given the opportunity to undertake pathologistdirected research explicitly in the field of surgical pathology, he founded the Cancer Diagnosis and Pathology website with a mission to facilitate research by surgical pathologists in surgical pathology. He has published extensively both within the structure of this group and in major international collaborations including the International Cancer Genome Consortium (ICGC) where he was a key member of the Australian Pancreatic Genome Initiative, initially as lead pathologist and now as chairman. He was awarded a personal chair as Professor of Surgical Pathology at the University of Sydney in Dr Gill has co-authored more than 240 original research publications (more than one quarter as senior scientific author) but is particularly proud of his work in the field of succinate dehydrogenase deficient neoplasia. While he fully acknowledges the work of many other research groups in this very active field, his work has been crucial to the widespread recognition of both succinate dehydrogenase deficient GIST and succinate dehydrogenase deficient renal cell carcinoma as unique entities with profound clinical significance. He has been a co-author of 10 WHO Blue Book chapters across three different books and was a member of the WHO Consensus Committee which met in Lyons, France (April ) to finalize the 4th Edition 2017 Genetics of Tumour of Endocrine Organs. He is grateful for the recognition that his work has achieved including the 2011 Benjamin Castleman Award from USCAP, the 2014 NSW Premier s Award for excellence in Translational Cancer Research and the NSW Cancer Institute Wildfire Award (twice). 6 He is particularly grateful to his surgical pathology collaborators and mentors. He has always felt welcomed by the international community of pathologists from around the world and, in particular, by USCAP.

159 BENJAMIN CASTLEMAN AWARD CARLOS A. MURGA-ZAMALLOA, M.D USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Dr. Carlos A. Murga-Zamalloa was born in Lima, Peru. He received his M.D. degree from San Martin de Porres University, Lima. Subsequently, he completed two postdoctoral trainings at the University of Michigan in Dr. Anand Swaroop s and Dr. Megan Lim s laboratories. In 2015, he completed his Anatomic and Clinical Pathology Residency at the University of Michigan and is currently a Hematopathology Fellow at the University of Michigan. Dr. Murga-Zamalloa has published 24 peer-reviewed manuscripts, one third of them as first-author. His current work focuses on the pathogenesis of T-cell lymphomas and specifically on the role of actin-related signaling networks during the development and progression of these types of tumors. His most recent work has demonstrated the role of Wiskott-Aldrich syndrome protein (WASp) in regulating the oncogenesis of anaplastic large cell lymphoma. Dr. Murga-Zamalloa has been the recipient of the 2014 Hematological Opportunities for the Next Generation of Research Scientists (HONORS) Award from the American Society of Hematology (ASH) and the 2015 Stowell-Orbison Award Certificate of Merit from the United States and Canadian Academy of Pathology (USCAP). He is currently working under the mentorship of Dr. Ryan Wilcox and Dr. Stephen Weiss at the University of Michigan. 7

160 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT THE F. STEPHEN VOGEL AWARD MATTHEW W. ROSENBAUM, M.D. Dr. Matthew W. Rosenbaum is a California native who studied biology and Japanese linguistics at Macalester College. After college, he received a Fulbright Fellowship to study longevity in Japan at the Okinawa Research Center for Longevity Science. He also studied biomedical translation at the Interuniversity Center for Japanese Linguistics in Yokohama, Japan. Upon his return from Japan, Matthew enrolled at Cornell University Medical School and spent time at the World Health Organization in Geneva and the University of Sydney in Westmead, Australia. He graduated receiving the Herman L. Jacobius Prize in Pathology and membership in the Alpha Omega Alpha Honor Medical Society. He is currently in his third year of anatomic and clinical pathology training at Massachusetts General Hospital, where his research interests include gastrointestinal pathology, cytopathology, molecular diagnostics, and the tumor immune microenvironment. He has received research awards from the Rodger C. Haggitt Gastrointestinal Pathology Society and Papanicolaou Society of Cytopathology. He is currently slated to complete a cytopathology fellowship at Massachusetts General Hospital and is excited to further his research and clinical training. 8

161 DR. L. CLARKE JR. & ELAINE F. STOUT ENDOWMENT AWARD NATALIA RUSH, M.D USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT Dr. Natalia Rush is a pathologist-in-training in the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis. She earned her Medical Degree from Indiana University School of Medicine and Bachelor of Science in Biomedical Engineering from Illinois Institute of Technology, Chicago. Her academic interests are hepatic, gastrointestinal, and solid organ transplant pathology. Dr. Rush enjoys academic research and will continue her training as a fellow in liver and gastrointestinal pathology at Indiana University School of Medicine. Dr. Romil Saxena is her mentor who shaped her interests in hepatic and gastrointestinal pathology; together they have worked on several interesting clinicopathologic research projects. One such project led to the paper Hepatic arterial buffer response: pathologic evidence in non-cirrhotic human liver with extrahepatic portal vein thrombosis published in Modern Pathology (2016; 29:489-99), for which Dr. Rush is being honored by USCAP s 2017 Dr. L Clarke Jr. and Elaine F. Stout Award. Intricacies of the hepatic microvasculature and sophistication of its compensatory mechanisms make the study of hepatic vascular physiology and hepatic vascular diseases particularly challenging in human subjects. The hepatic arterial buffer response has been well documented in animals and has been demonstrated during surgery by imaging modalities in human subjects, but has persistently defied pathologic study. Using time honored principles of histopathologic observations and morphometric analyses, Dr. Rush and colleagues have provided pathologic evidence of a compensatory hepatic vascular physiologic response that is essential for maintaining whole body homeostasis. Their paper thus honors the Dr. L Clarke Jr. and Elaine F. Stout Award s founding principle of solving a medical problem based on anatomic studies. 9

162 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT DR. FLORABEL G. MULLICK AWARD MARIA FRANCES BUKELO, MBBS, M.D. Dr. Maria Frances Bukelo was raised in the coastal town of Mangalore, South India. Her keen interest in biology secured her admission to the St. John s National Academy of Health Sciences where she earned her Bachelor of Medicine and Bachelor of Surgery (MBBS) degrees from St. John s Medical College in Bangalore. She completed her residency training in Anatomic Pathology and Clinical Pathology from Fr. Muller Medical College in Mangalore during which she conducted a clinicopathological study of Multiple Myeloma for her M.D. dissertation. On obtaining her M.D. Pathology degree she joined the Department of Pathology at St. John s Medical College, Bangalore and has been working as Lecturer of Pathology since October 2013 and was just promoted to Assistant Professor of Pathology. Since her undergraduate days Dr. Bukelo has shown keen interest in research and is currently the recipient of the prestigious Wellcome Trust/DBT India Alliance Research Training Fellowship. She is working on the genotypic characterisation of Hirschsprung s Disease in the Indian cohort under the mentorship of Dr. Usha Kini, a pioneer in diagnostics of Hirschsprung s Disease in India. Dr. Bukelo also spends part of her time at the National Centre for Biological Sciences, Bangalore where she carries out her genomicsrelated work at Professor Sudhir Krishna s laboratory. In addition to her professional achievements, she maintains a huge rare Medical Philately collection which has been on exhibitions. On a personal note, she is honoured to be the second recipient of the Dr. Florabel G. Mullick Award. I thank the USCAP Foundation for enabling pathologists across the globe to witness cutting edge pathology, in its endeavours to reach out to areas of need. I remain grateful to all those who have mentored me in my career path and to all who have challenged me to grow and reflect in new ways about clinical diagnostics and laboratory research. This award is dedicated to my parents for their unconditional love and constant encouragement to push boundaries and offer my best. 10

163 USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT STOWELL-ORBISON AWARDS The Stowell-Orbison Awards are for trainees who are currently residents or fellows in pathology. USCAP offers up to four awards of $500 to pathologists-in-training who present the best research work through the medium of a poster presentation. In addition to these cash awards, a limited number of certificates of merit may also be presented. Applicants can submit only one paper per author, and the first author must be a pathologistin-training who had a major role in the study. Posters for this competition will be judged by members of the USCAP Stowell- Orbison Awards Committee based on originality, impact, design, presentation, and trainee input. The pathologist-in training (first author) must be present during the entire poster session to be considered for this award. SURGICAL AND AUTOPSY PATHOLOGY AWARDS The Association of Directors of Anatomic and Surgical Pathology (ADASP) and USCAP co-sponsor two additional awards of $500 each to pathologists-in-training for the best posters on a morphology-based surgical pathology study and on autopsy material, respectively, presented as part of the Stowell- Orbison competition. Applicants may win either of these awards alone, or they may win them in addition to a Stowell-Orbison Award. Eligibility is the same as for the Stowell-Orbison abstracts. Applicants can submit only one paper per author, and the first author must be a pathologist-intraining. Posters for this competition will be judged by a panel of members of the ADASP. STOWELL-ORBISON AWARDS & SURGICAL PATHOLOGY AND AUTOPSY AWARDS FOR PATHOLOGISTS-IN-TRAINING Papers accepted for both of these competitions will be presented as posters on Monday morning of the USCAP Annual Meeting. The names of the winners will be revealed by noon on Tuesday and the awards presentation will be at the USCAP Honors on Tuesday afternoon. Only one paper per person is eligible for this competition. In order to qualify, the potential awardee must have had a major role in the development of the studies leading to the abstract and must be listed as the first author of the paper. The abstract must be original and not previously published or presented, nor currently accepted for publication or presentation at another meeting prior to the USCAP Annual Meeting. An application form for these awards is available through the electronic abstract submission program. In order to be entered into the competition for these awards you must complete the online form and have your in training status verified online by the department chairman or program director. No abstract can be entered in the competition unless this online form has been completed prior to submission. Abstracts submitted for this competition, but not selected, are automatically considered for acceptance as a regular abstract presentation. 11

164 PREVIOUS AWARD WINNERS USCAP HONORS HIGH PERFORMANCE ACHIEVEMENT BOARD S DISTINGUISHED PATHOLOGIST AWARD Previous Winners: 2016 Thomas V. Colby 2015 Sharon W. Weiss 2014 Henry Appelman 2013 Kris Unni 2012 Steven Silverberg 2011 Stephen S. Sternberg 2010 Juan Rosai 2009 Louis P. Dehner 2008 Nathan Kaufman/ Bernard M. Wagner 2007 Peter Burger 2006 Harvey Goldman 2005 Robert D. Collins 2004 Kalman Kovacs/ Daria Haust 2003 Richard L. Kempson 2002 William Hartmann/ Robert Heptinstall 2001 Margaret Billingham / Leopold Koss 2000 John Yardley 1999 David Dahlin 1998 Robert E. Scully 1997 Elson Helwig 1996 Raffaele Lattes 1995 Henry Rappaport 1994 Franz Enzinger 1993 Wallace Clark 1992 Emmanuel Farber 1991 Stanley Robbins 1990 Arthur Hertig 1989 Earl Benditt 1988 Hans Popper HARVEY GOLDMAN MASTER TEACHER OF THE YEAR AWARD Previous Award Winners: 2016 Linda Ferrell 2015 Victor Reuter 2014 Christopher Fletcher 2013 Sharon Weiss 2012 Virginia LiVolsi 2011 Donald Antonioli / Henry Appelman THE F.K. MOSTOFI DISTINGUISHED SERVICE AWARD Recipients for Previous Years: 2016 Julia A. Bridge 2015 Linda Ferrell 2014 Fred Barr 2013 John Goldblum 2012 Celeste Powers 2011 Sylvia L. Asa 2010 John Eble 2010 James Crawford 2009 Jeffrey L. Myers 2008 Richard Fraser 2007 Victor E. Reuter 2006 Richard Zarbo 2005 Ronald A. DeLellis 2004 Donald A. Antonioli 2003 Elaine S. Jaffe 2002 Robert Pascal 2001 Virginia LiVolsi 2000 Fred G. Silva 1999 William A. Gardner 1998 Costan Berard 1997 Cecilia M. Fenoglio- Preiser 1996 Emanuel Rubin 1995 Harvey Goldman 1994 David F. Hardwick Bernard M. Wagner 1992 Kenneth M. Earle 1991 Kamal Ishak 1990 Nathan Kaufman 1989 Benjamin F. Trump 1988 Jack P. Strong 1987 Stephen Vogel 1986 Leland Stoddard 1985 Robert More 1984 Murray Abwell 1983 Richard Palmer 1982 Jack Layton 1981 Benjamin Castleman 1980 Joshua Edwards 1979 Robert Stowell 1978 Chapman Binford 1977 Harold Stewart THE MAUDE ABBOTT LECTURE Previous Lecturers: 2016 Stuart J. Schitt 2015 Ricardo V. Lloyd 2014 Ralph Hruban 2013 Victor Reuter 2012 Robert Kurman 2011 Elaine Jaffe 2010 Henry Appelman 2009 Michael Gimbrone 2008 Christopher Fletcher 2007 Virginia LiVolsi 2006 Anna-Luise Katzenstein 2005 David Page 2004 Aidan Carney 2003 James Downing 2002 Peter Isaacson 2001 Sharon Weiss 2000 Roger Haggitt 1999 Richard Kempson 1998 Louis P. Dehner 1997 Charles Hirsch 1996 Ramzi Cotran 1995 Juan Rosai 1994 Morris Karnovsky 1993 Ronald Dorfman 1992 Robert Scully 1991 Guido Majno 1990 Emanuel Rubin 1989 Leopold Koss 1988 Marilyn Farquhar 1987 Emmanuel Farber 1986 Paul Lacy 1985 Kenneth Brinkhous 1984 William Christopherson 1983 Robert Heptinstall 1982 Raffaele Lattes 1981 Lauren Ackerman 1980 Walter Sandritter THE PRESIDENT S AWARD Past Awardees: 2016 Celeste N. Powers 2015 E. Blair Holladay 2014 Richard L. Kempson 2013 Jean Silva 2012 Robin Cooke 2011 Fred Silva 2010 Jeffrey Myers 2009 JoAnn Johnson 2008 Jack Strong 2007 James Crimmins 2006 USCAP Staff 2005 Andrew Huvos 2004 David Hardwick 2003 Kamal Ishak 2002 Ruth Kirchstein and Alan Rabson 2001 Ramzi Cotran THE NATHAN KAUFMAN TIMELY TOPICS LECTURE Previous Speakers: 2016 Eric F. Glassy 2015 Otis W. Brawley 2014 Arul Chinniyan 2013 Christopher Crum 2012 Bogdan Czerniak 2011 Guillermo J. Teamey 2010 Anthony Atala 2009 Todd Golub 2008 Frank McKeon 2007 Steven L. Kunkel 2006 Tyler Jacks 2005 Phillip Sharp 2004 David H. Walker 2003 Irving L. Weissman 2002 Lance Liotta 2001 James Madera 2000 Peter M. Howley 1999 Anthony S. Fauci 1998 David Korn 1997 Raymond White 1996 Anthony Epstein 1995 Eric Stanbridge 1994 Francis Collins 1993 Judah Folkman 1992 French Anderson 1991 Stanley Cohen 1990 Philip Leder 1989 Jay Levy 1988 Cecilia Fenoglio-Preiser 1987 Ronald Weinstein 1986 James Curran 1985 Robert Leader 1984 Arthur Upton & Robert Squire 1983 Edwin Ewing & Thomas Spira THE BENJAMIN CASTLEMAN AWARD Previous Winners: 2016 Benjamin Durham 2015 Mark J. Kiel 2014 Valentina Nardi 2013 Abner Louissant 2012 Daniel Winer 2011 Anthony Gill/ Jiaqi Shi 2010 Adeboye Osunkoya 2009 Kirsten D. Mertz 2008 Laurence de Leval 2007 Adebowale Joel Adeniran 2006 Arul M. Chinnaiyan 2005 Andrew P. Weng 2004 Anirban Maitra 2003 Jerome T. O Connell 2002 David G. Huntsman 2001 Todd Kroll 2000 Daniel J. Brat 1999 Irina Lubensky 1998 Jeffrey K. Taubenberger 1997 Sarah S. Frankel 1996 Frederic G. Barr 1995 Marc Ladanyi 1994 Cheryl Willman 1993 Timothy McDonnell 1992 Giorgio Ingrahami 1991 Peter Humphrey 1990 Ivan Stamenkovic 1989 Stephen Peiper 1988 John Anastasi 1987 James Kurnick 1986 Lawrence Weiss 1985 Ann Thor 1984 George Murphy 1983 Renatao Iozzo 1982 William Beschorner 1981 Roger Warnke F. STEPHEN VOGEL AWARD Previous Winners: 2016 Charlotte Kweldam 2015 Patrick J. Cimino 2014 Ghassan Allo 2013 Bojana Djordjevic 2012 Elizabeth Demicco 2011 Jose Gaal 2010 Ibrahim Batal 2009 Samantha L. Butler 2008 Jeremy Wallentine 2007 Donna E. Hansel 2006 Rohit Bhargava 2005 Dylan V. Miller 2004 Robert Pu 2003 Dinesh Rakheja 2002 Ilene B. Bayer-Garner 2001 Pei Hui 2000 Julie Teruya-Feldstein THE RAMZI S. COTRAN YOUNG INVESTIGATOR S AWARD Previous Winners: 2016 Donna Hansel 2015 Charles Mullighan 2014 John Iafrate 2013 Celina Kleer 2012 Cristina Antonescu 2011 Shuji Ogino 2010 Jorge S. Reis-Filho 2009 Christine Iacobuzio- Donahue 2008 Anirban Maitra 2007 Arul M. Chinnaiyan 2006 Kojo S. J. Elenitoba- Johnson 2005 Marc Ladanyi 2004 Mark A. Rubin 2003 Julia A. Bridge 2002 Frederic G. Barr 2001 Ralph Hruban 2000 Mary Sunday 1999 Lawrence M. Weiss 1998 Cheryl L. Willman 1997 Christopher D. M. Fletcher 1996 James R. Downing DR. L. CLARKE JR. AND ELAINE F. STOUT ENDOWMENT AWARD Previous Winners: 2016 Nikhil Sangle 2015 Ming Jin

165 ABSTRACTS #IAMUSCAP #USCAP2017

166 WHAT S CONCRETE ABOUT THE ABSTRACT? While USCAP is proud of the way it delivers scalpel-edge education, the Academy is equally dedicated to research. Annual Meeting 2017 attracted 2,722 abstract submissions in all subspecialty areas of translational research in anatomic and molecular pathology. USCAP moves core research from 2017 ABSTRACT STATS 2,722 Abstracts Submitted 280 Accepted for Platform Presentations 1,583 Accepted for Posters (298 of these Posters are in Competition for Stowell-Orbison Awards) platforms and posters to the clinical sphere, leading progress in new diagnostic criteria and novel targeted therapies.

167 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 CC SNB 3&4 SECTION A GENITOURINARY CHAIRED BY: DEBRA L ZYNGER AND SCOTT A TOMLINS 8:00 Molecular Characterization of Prostatic Adenocarcinoma Gleason 4, Cribriform Pattern (897) Habiba Elfandy, Filippo Pederzoli, Eli Pullman, Svitlana Tyekucheva, Nikolaus Schultz, Massimo Loda. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; National Cancer Institute, Cairo University, Cairo, Egypt; Vita-Salute San Raffaele University, Milan, Italy; George Washington University, Washington, DC; Harvard School of Public Health, Boston, MA; Memorial Sloan Kettering Cancer Center, New York, NY; BWH, Harvard Medical School, Boston, MA; DFCI, Boston, MA. 8:15 Microsatellite Unstable (MSI-H) Prostate Cancer (PCA): Correlation of Morphology, Mismatch Repair Immunohistochemistry (MMR-IHC) and Next Generation Sequencing (NGS) (916) Anuradha Gopalan, Wassim Abida, Sumit Middha, Joshua Armenia, Joseph S Sirintrapun, Ying-Bei Chen, Hikmat Al-Ahmadie, Samson W Fine, Satish K Tickoo, David Solit, Michael F Berger, Nikolaus Schultz, Howard I Scher, Jinru Shia, Victor E Reuter. MSKCC, NY, NY. 8:30 Gene Expression Meta-Signature Identifies INSM1 Expression and YAP1 Loss as Markers of Neuroendocrine Prostate Cancer (1057) Alba FC Torres, Harrison Tsai, Lisa M Rooper, William H Westra, Tamara L Lotan. Johns Hopkins School of Medicine, Baltimore, MD. 8:45 PTEN Loss in Gleason Score 3+4=7 Prostate Biopsies Is Associated with Non-Organ Confined Disease at Radical Prostatectomy (859) Liana Benevides Guedes, Jeff Tosoian, Jessica Hicks, Ashley E Ross, Tamara L Lotan. Johns Hopkins University School of Medicine, Baltimore, MD. 9:00 Genomic Alterations of PTEN, CHD1, ASAP1, and Aneusomy Are Associated with Prognostic Grade Group Upgrade from Needle Biopsy to Prostatectomy (990) Prasuna Muppa, R Jeffrey Karnes, Stephen J Murphy, Farhad Kosari, Irina V Kovtun, Laureano J Rangel, William R Sukov, Rafael E Jimenez, George Vasmatzis, John C Cheville. Mayo Clinic, Rochester, MN. 9:15 Histological Patterns of Ductal Adenocarcinoma of Prostate Correlates with Mutations in DNA Repair Genes and May Aid in Selecting the Type of Systemic Therapy for Castration-Resistant Prostate Carcinoma (1066) Lawrence True, Roman Gulati, Jane Lange, Maria Tretiakova, Funda Vakar-Lopez, Peter Humphrey, Lars Egevad, Ondrej Hes, Tatjana Antic, Heather H Cheng, Bruce Montgomery, Peter Nelson, Eric Q Konnick, Michael Schweizer, Colin Pritchard. University of Washington, Seattle, WA; Yale University, New Haven, CT; Karolinska Institute, Stockholm, Sweden; Fred Hutchinson Cancer Center, Seattle, WA; University of Chicago, Chicago, IL; Charles University, Plzeň, Czech Republic. 11:00 Are Men with Gleason Score 3+4=7 Cancer on Biopsy Candidates for Active Surveillance? (899) Jonathan I Epstein, Jeff Tosoian. Johns Hopkins Hospital, Baltimore, MD. 11:15 Clinicopathologic Characteristics of Patients with Very Low-Risk (PI-RADS 1 or 2) Lesions by Multiparametric Prostate Magnetic Resonance Imaging (1068) Aaron Udager, Joel Friedman, Nicole Curci, John Wei, Chandy Ellimoottil, Rohit Mehra, Scott A Tomlins, Jeffrey S Montgomery, Matthew Davenport, Angela Wu, Lakshmi P Kunju. University of Michigan Health System, Ann Arbor, MI. 11:30 Histologic Spetrum of Metastatic Castration-Resistant Prostate Cancer (934) Jiaoti Huang, Yu Yin, George Thomas, Lawrence True, Tomasz M Beer, Martin Gleeve, Owen Witte, Josh Stuart, Chris Evans, Adam Foye, Jack Youngren, Eric Small. Duke University, Durham, NC; Anhui Medical University, Hefei, Anhui Province, China; Oregon Health Sciences University, Portland, OR; University of Washington, Seattle, WA; University of British Columbia, Vancouver, BC, Canada; UCLA, Los Angeles, CA; UC Davies, Sacramento, CA; UCSF, San Francisco, CA. 11:45 Impact of the 2014 International Society of Urological Pathology (ISUP) Modified Gleason Grading on Previously Diagnosed Gleason Score 6 Prostate Cancers in Radical Prostatectomies (877) Bonnie Choy, Shane M Pearce, Blake B Anderson, Gladell P Paner. University of Chicago, Chicago, IL. 12:00 BREAK 107

168 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 CC HEMISFAIR 1 SECTION B BREAST CHAIRED BY: BENJAMIN C CALHOUN AND DEBORAH A DILLON 8:00 Composite Analysis of Immunological and Metabolic Markers Defines Novel Subtypes of Triple Negative Breast Cancer (TNBC): Prognostic Significance and Implications for Immunotherapy (100) Thomas A Adams, Paris J Vail, Erik S Knudsen, Agnieszka K Witkiewicz. University of Arizona, Tucson, AZ. 8:15 Quality, Not Quantity : 10X Hot-Spot (HS) Analysis of Lymphocyte Markers (CD3, CD8, CD4, CD20) in Tumor- Infiltrating Lymphocytes (TILs) Is Superior to Whole Tumor (WT) Analysis in Triple-Negative Breast Cancer (TNBC) (225) Patrick J McIntire, Paula Ginter, Lina Irshaid, Xiaoyan Cui, Zhengming Chen, Sandra J Shin. Weill Cornell Medicine, New York, NY. 8:30 Metabolic and Immune Features of High Risk DCIS (237) David A Nolte, Paris J Vail, Erik S Knudsen, Agnieszka K Witkiewicz. University of Arizona, Banner University Medical Center, Tucson, AZ. 8:45 Evaluating the Checkpoint Immune System in HER2- Positive Breast Carcinoma with Anti-PD-L1 Multiplex Immunohistochemistry and Its Association with the Response to Anti-HER2 Neoadjuvant Chemotherapy (213) Zaibo Li, Hiroaki Nitta, Peter Banks, Yanjun Hou, Anil Parwani. Ohio State University, Columbus, OH; Ventana Medical Systems, Inc, Tucson, AZ. 9:00 PD-1, PD-L1, and B7-H3 Expression in Intrinsic Molecular Subtypes of Breast Cancer (259) Gary Rose, Stephanie Richards, Paula Rosenblatt, Madhurima Koka, Kimberly Tuttle, Ashley Cellini, Olga Ioffe. University of Maryland School of Medicine, Baltimore, MD. 9:15 Correlation of Tumor-Infiltrating Lymphocytes (TILs) with Residual Cancer Burden in Patients Treated with Neoadjuvant Chemotherapy (NAC) for Invasive Breast Carcinoma with a Focus on TILs Assessment in Heterogeneous Cases (127) Esther Cheng, Sandra Demaria, David Ko, Zhengming Chen, Tracy-Ann Moo, Eleni Andreopoulou, Timothy D Alfonso. Weill Cornell Medicine, New York, NY. 11:00 Evaluation of the Breast Myoepithelial Cell Layer by Physical Expansion of Tissue Microarrays (121) Octavian Bucur, Yongxin Zhao, Vanda Torous, Edward Boyden, Andrew H Beck, Stuart J Schnitt. Beth Israel Deaconess Medical Center, Boston, MA; MIT, Cambridge, MA. 11:15 Genomic Profiling of Pure Apocrine Carcinoma (261) Jeanette Ruiz, Gregor Krings, Deepika Sirohi, Nancy M Joseph, Elizabeth Hosfield, Timothy Jacobs, Yunn-Yi Chen. UCSF, San Francisco, CA; Kaiser, Oakland, CA; Virginia Mason Med Ctr., Seattle, WA. 11:30 Histopathologic Subgroups of AR+ TNBC Predict Pathologic Complete Response to Neoadjuvant Chemotherapy in Localized Breast Cancer (164) Paula Gonzales-Ericcson, Ingrid A Mayer, Bojana Jovanovic, Brian Lehmann, Monica V Estrada, Gabriela Kuba, Vandana Abramson, Erica Mayer, Patrick Dillon, Bardia Aditya, Jenny Chang, Andres Forero, Ingrid Meszoely, Ana Grau, Jennifer Pietenpol, Melinda Sanders. Vanderbilt University, Nashville, TN; Dana Farber Cancer Center, Boston, MA; University of Virginia Health Sciences Center, Charlottesville, VA; Massachusetts General Hospital, Boston, MA; Methodist Hospital Research Institute, Houston, TX; University of Alabama, Birmingham, AL. 11:45 The Molecular Mechanisms of Parity Driving Breast Cancer Etiology (117) Francisco Beca, Yujing Jan Heng, A Heather Eliassen, Rulla Tamimi, Sue Hankinson, Andrew H Beck. Beth Israel Deaconess Medical Center, Boston, MA; Harvard Medical School, Boston, MA; Harvard T.H. Chan School of Public Health, Boston, MA; University of Massachusetts Amherst, Amherst, MA. 12:00 BREAK CC 225 SECTION C CYTOPATHOLOGY CHAIRED BY: CHRISTOPHER VANDENBUSSCHE AND SINCHITA ROY-CHOWDHURI 8:00 Performance of the Aptima and Cobas HPV Testing Platforms in Detecting High Grade Cervical Dysplasia and Cancer (370) Yimin Ge, Paul Christensen, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina Mody. Houston Methodist Hospital, Houston, TX; Weill Medical College of Cornell University, New York, NY; BioReference Laboratories, Houston, TX. 8:15 Cervical Biopsy Rates Before and After the Introduction of HPV Type Reporting in Co-Tests with Negative Cytology (440) Heather Ruff, Dina Mody, Eric Luna, Donna Armylagos, Michael J Thrall. Houston Methodist Hospital, Houston, TX; BioReference Laboratories, Houston, TX. 108

169 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:30 Comparison of HPV DNA and HPV mrna Testing in a Cervical Primary Screening Population (435) Stephen Reynolds, Christine White, Padmaja Naik, Roisin O Brien, Trinh Pham, Imogen Sharkey Ochoa, Carrie Powles, Noel Bolger, Jacqui Barry O Crowley, Prerna Tewari, Sharon O Toole, Charles Normand, Linda Sharp, Grainne Flannelly, John J O Leary, Cara M Martin. Trinity College Dublin, Dublin, Ireland; Coombe Women & Infants University, Dublin, Ireland; Newcastle University, Newcastle on Tyne, United Kingdom; National Screening Service, Dublin, Ireland. 8:45 Impact of High-Risk Human Papillomavirus Testing on Pap Test Screening Complexity (469) Vanda Torous, Dawn Brancely, Luis Carpio, Paul VanderLaan. Beth Israel Deaconess Medical Center, Boston, MA. 9:00 Anal High Risk HPV Genotyping and Correlation with Biopsy Outcomes (407) Dan Lu, David Chhieng, Michael Gaisa, Keith Sigel, Qiusheng Si. Icahn School of Medicine at Mount Sinai, New York, NY. 9:15 Comparative Characterization of Genotype Profiles of High-Risk Human Papillomavirus (hrhpv) Infection in Male and Female HIV Positive Patients and Their Correlation with Anal Cytology and Biopsy (485) Xiaofei Zhang, David Chhieng, Michael Gaisa, Keith Sigel, Dan Lu, Yuxin Liu, Tamara Kalir, Qiusheng Si. The Mount Sinai Hospital, Icahn School of Medicine, New York, NY. 11:00 Cytologic Evaluation of p16 Staining in Head and Neck Squamous Cell Carcinoma in Cytolyt vs Formalin-Fixed Material (344) Darren Buonocore, Jean-Marc Cohen. Memorial Sloan Kettering Cancer Center, New York, NY. 11:15 Using the Rate of Positive UroVysion FISH Test Results Together with the Atypical Urothelial Cells (AUC)/ High Grade Urothelial Carcinoma (HGUC) Ratio in Evaluating the Performance of Cytopathologists (427) Stefan Pambuccian, Guliz Barkan, Eva M Wojcik. Loyola University, Maywood, IL. 11:30 Atypical Urothelial Cells (AUC) Diagnosis Rates and AUC/High Grade Urothelial Carcinoma (AUC/HGUC) Ratios Vary in Different Urinary Cytology (UCy) Specimen Types (428) Stefan Pambuccian, Guliz Barkan, Eva M Wojcik. Loyola University, Maywood, IL. 11:45 Polyoma (BK) Virus Cytopathic Effect in Urine Cytology Is Not Associated with High Risk of Developing Urothelial Carcinoma (408) Haiyan Lu, Tarik M Elsheikh, Yaxia Zhang. Cleveland Clinic Foundation, Cleveland, OH. 12:00 BREAK CC HEMISFAIR 3 SECTION D GASTROINTESTINAL CHAIRED BY: JINRU SHIA AND RAUL S GONZALEZ 8:00 Immunohistochemical and Molecular Characterization of Dysplasia Subtypes in Ulcerative Colitis (776) Deepa T Patil, John R Goldblum, Robert D Odze. Cleveland Clinic, Cleveland, OH; Brigham and Women s Hospital, Boston, MA. 8:15 Structural Genomic Changes in IBD-Related Dysplasia and Preceding Copy Alterations in Corresponding Non-Dysplastic Mucosa (810) Diana Sung, Alain C Borczuk, Alina Iuga. Columbia University Medical Center, New York, NY; Weill Cornell Medical College, New York, NY. 8:30 Targeted Mutational Analysis in IBD-Associated Colorectal Cancer (629) Lindsay Alpert, Lindsay Yassan, Sabah Kadri, Ibro Mujacic, Nifang Niu, David Montez, Filippo D Galbo, Michelle N Wurst, Chao J Zhen, Christopher Weber, Shu-Yuan Xiao, John Hart, Jeremy Segal, Namrata Setia. University of Chicago, Chicago, IL. 8:45 Detection of Anaplastic Lymphoma Kinase (ALK) Rearrangement in Colorectal Cancer: An Immunohistochemical Study of 128 Cases (763) Sahar Nozad, Sungeun Kim, Hwajeong Lee, Christine E Sheehan, David M Jones, Jeffrey Ross. Albany Med Col, Albany, NY. 9:00 Detection of Mutations in DNA Polymerase Ɛ (POLE) in Colorectal Carcinoma with Intact Mismatch Repair Proteins: Immunotherapeutic Implications of Ultramutation (688) Adam J Gomez, Ann Burton, David Steiner, James Zehnder, Teri Longacre. Stanford Health Care, Stanford, CA. 9:15 Somatic Genetic Alterations in Mismatch Repair Deficient Colorectal Carcinomas Not Associated with Lynch Syndrome (792) Christophe Rosty, Mark Clendenning, Aung K Win, Finlay Macrae, Ingrid Winship, John Hopper, Mark Jenkins, Dallas English, Daniel Buchanan. Envoi Pathology, Brisbane, Australia; University of Melbourne, Melbourne, Australia. 11:00 Immune Checkpoint Expression and the Tumor Immune Environment in Colorectal Carcinoma (789) Matthew W Rosenbaum, Jacob R Bledsoe, Marina Kem, Tiffany Huynh, Mari Mino-Kenudson. Massachusetts General Hospital, Boston, MA; University of Massachusetts Medical School, Worcester, MA. 109

170 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 11:15 Tumor Budding Assessed by the International Tumor Budding Consensus Conference (ITBCC) Recommendations Is a Strong Predictor of Disease- Free Survival in Stage II Colorectal Cancer (673) Heather Dawson, Naziheh Assarzadegan, Richard Kirsch, Robert H Riddell, Inti Zlobec, Alessandro Lugli. Institute of Pathology, University of Bern, Bern, Switzerland; University of Florida, Gainesville, FL; Mount Sinai Hospital, University of Toronto, Toronto, Canada. 11:30 Epstein-Barr Virus Infection in Refractory Inflammatory Bowel Disease Patients Undergoing Colectomy (780) Maryam Pezhouh, Ogechukwu Pearl Eze, Yaman Tarabishy, Kevin Waters, Alyssa Parian, Mark Lazarev, Elizabeth A Montgomery, Lysandra Voltaggio. Johns Hopkins Hospital, Baltimore, MD. 11:45 Normative Diagnostic Concordance for Low-Grade Appendiceal Mucinous Neoplasms and Related Primary Appendiceal Lesions (818) Mark A Valasek, Irene Thung, Esha Gollapalle, Alexey A Hodkoff, Vera Vavinskaya, Joel M Baumgartner, Andrew M Lowy. University of California San Diego, San Diego, CA; University of California San Diego, La Jolla, CA. 12:00 BREAK CC 304 SECTION E GYNECOLOGIC CHAIRED BY: CARLOS PARRA-HERRAN AND NATALIA BUZA 8:00 Mucinous Differentiation Is Predictive of Improved Outcomes in Low Grade Endometrioid Carcinoma (1093) Eman Abdulfatah, Sudeshna Bandyopadhyay, Oumaima Chaib, Andres A Roma, Denise Barbuto, Elizabeth Euscher, Bojana Djordjevic, Elizabeth E Frauenhoffer, Delia P Montiel, Anais Malpica, Elvio Silva, Rouba Ali-Fehmi. WSU, Detroit, MI; UC, San Diego, CA; CSMC, LA, CA; MDAnderson, Houston, TX; Ottawa, Ott, ON, Canada; Penn State, Hershey, PA; I N C, Mexico, Mexico. 8:15 Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups (1113) Tjalling Bosse, Remi A Nout, Jessica N McAlpine, Melissa McConechy, Heidi Britton, Raji Ganesan, Jane C Steele, Beth T Harrison, Esther Oliva, Xavier Matias- Guiu, Blake Gilks, Robert Soslow. Leiden University Medical Center, Leiden, Netherlands; University of British Columbia, Vancouver, Canada; University of British Columbia and BC Cancer Agency, Vancouver, Canada; Birmingham Women s HS Foundation Trust, Birmingham, United Kingdom; Massachussets General Hospital, Boston, MA; Hospital U Arnau de Vilanova and Hospital U de Bellvitge, Lleida, Spain; Memorial Sloan Kettering Cancer Center, New York, NY; McGill University, Montreal, Canada. 8:30 Molecular Modifiers of the Tumor Immune Microenvironment: Activation of the Wnt/β-Catenin Pathway Is Associated with Local Immunosuppression in Endometrial Cancer (1187) Katherine Kurnit, Mark Munsell, Russell R Broaddus. MDACC, Houston, TX. 8:45 Intraoperative Pathologic Consultation on Hysterectomy Specimens for Endometrial Cancer: An Assessment of the Accuracy of Frozen Sections, Gross Only Evaluations and Obtaining Random Sections of a Grossly Normal Endometrium (1132) Mohamed M Desouki, Zaibo Li, Omar Hameed, Oluwole Fadare. Vanderbilt University Medical Center, Nashville, TN; Ohio State University, Cincinnati, OH; University of California San Diego, San Diego, CA. 9:00 Pathologic Ultrastaging of Endometrial Cancer Sentinel Lymph Nodes: The Dartmouth-Hitchcock Medical Center Experience (1134) Jessica Dillon, Jorge L Gonzalez, Evelyn L Fleming, Laura Tafe. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 9:15 Inflammatory Myofibroblastic Tumor of the Uterus: A Clinicopathological, Immunohistochemical, and Molecular Analysis of 13 Cases (1109) Jennifer Bennett, Valentina Nardi, Marjan Rouzbahman, Vicente Morales-Oyarvide, Kyu-Rae Kim, G P Nielsen, Esther Oliva. Lahey Hospital, Burlington, MA; Massachusetts General Hospital, Boston, MA; Toronto General Hospital, Toronto, ON, Canada; Dana Farber Cancer Institute, Boston, MA; University of Ulsan, Seoul, Korea. 11:00 Abnormal p53 and p16 Staining Patterns Distinguish Uterine Leiomyosarcoma from Inflammatory Myofibroblastic Tumor (1233) Inga-Marie Schaefer, Jason L Hornick, Lynette M Sholl, Bradley J Quade, Marisa R Nucci, Carlos Parra-Herran. Brigham and Women s Hospital/Harvard Medical School, Boston, MA; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. 11:15 Genomic Index Assessment in Uterine Smooth Muscle Lesions: A Prognostic Tool Predictive of Recurrence. A Comprehensive Array-CGH Analysis of 77 Tumours (1128) Sabrina Croce, Agnes Ribeiro, Tom Lesluyes, Jean- Christophe Noel, Mojgan Devouassoux-Shisheboran, Laurent Arnould, Gaëtan MacGrogan, Frédéric Chibon. Institut Bergonié, Bordeaux, France; Erasme University Hospital, Bruxelles, Belgium; Centre Hospitalier Lyon Sud, Pierre Bénite, Lyon, France; Centre JF Leclerc, Comprehensive Cancer Centre, Dijon, France. 11:30 Uterine Adenomatoid Tumor: A Neoplasm Having Frequent Association with Immunosuppressive Therapy (1249) Daisuke Tamura, Daichi Maeda, Sultan A Halimi, Masato Okimura, Yukihiro Terada, Akiteru Goto. Akita University, Akita, Japan; Kabul Medical University, Kabul, Afghanistan. 110

171 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 11:45 BCOR Is a Robust Diagnostic Immunohistochemical Marker of YWHAE-Rearranged High-Grade Endometrial Stromal Sarcoma (1125) Sarah Chiang, Martee Hensley, Cristina R Antonescu, Esther Oliva, Robert Soslow. Memorial Sloan Kettering Cancer Center, New York, NY; Massachusetts General Hospital, Boston, MA. 12:00 BREAK CC 301 SECTION F TECHNIQUES (INCLUDING ULTRASTRUCTURE) CHAIRED BY: ANIL PARWANI AND LAKSHMI P KUNJU 8:00 InDelDuper: A Highly Sensitive and Specific Algorithm for FLT3 ITD Detection in Next-Generation Sequencing Data (2120) Yi Ding, William Crowe, Todd Laughlin, John Spence, Jan Spence, Paul G Rothberg, Richard Burack. University of Rochester Medical Center, Rochester, NY. 8:15 Predictive Cytologic Topography Improves Detection of High-Grade Prostate Cancer on MRI (2131) Ken A Iczkowski, Amy Kaczmarowski, Sarah L Hurrell, Anjishnu Banerjee, Kenneth Jacobsohn, Sean McGarry, Mark Hohenwalter, Peter S LaViolette. Medical College of Wisconsin, Milwaukee, WI. 8:30 Performance Evaluation of Copan s Elution Swab Collection and Transport System for Preservation and Recovery of Mycobacteria and Fungi (2144) Dennise E Otero, Lawrence Esper, Lorraine Sykes, Suresh B Selvaraju. MetroHealth Medical Center, Cleveland, OH. 8:45 Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides (2113) Javier A Baena Del Valle, Qizhi Zheng, Jessica Hicks, Helen Fedor, Bruce J Trock, Colm Morrissey, Eva Corey, Toby C Cornish, Karen S Sfanos, Angelo M De Marzo. The Johns Hopkins University, Baltimore, MD; Fundacion Santa Fe De Bogota, Bogota DC, Colombia; University of Washington, Seattle, WA; University of Colorado School of Medicine, Aurora, CO. 9:00 Detection of Acute Myeloid Leukemia on Flow Cytometry Data from 351 Subjects Using Machine Learning Technology (2109) Cesar Angeletti. Logical Cytometry, Atlanta, GA. 9:15 Validation of Automated Digital Image Analysis in Evaluating the Prognostic Significance of T-Bet Positive Lymphoid Cells in Lymph Node Negative Breast Cancer (2158) Phillip Williams, Lucine Collins, Dushanthi Pinnaduwage, Irene Andrulis, Anna Marie Mulligan. University of Toronto, Toronto, ON, Canada. 11:00 Clarification of Prostate Core Needle Biopsies with 2,2 Thiodiethanol Rapidly and Efficiently Prepares Tissue for 3D Light-Sheet Microscopy (2137) Erin McCarty, Nicholas P Reder, Adam K Glaser, Ye Chen, Jonathan TC Liu, Lawrence True. University of Washington Medical Center, Seattle, WA; University of Washington, Seattle, WA. 11:15 Pathologic Evaluation of a Novel Thermal Accelerant Used in Microwave Tumor Ablation (2135) Kara A Lombardo, William KC Park, Aaron WP Maxwell, Edward G Walsh, Michael P Primmer, Scott A Collins, Damian E Dupuy, Shaolei Lu. Brown University Alpert Medical School, Providence, RI. 11:30 The Combined Use of Thermoresponsive NanoVelcro Exosome Purification System and Droplet Digital RT- PCR Enables Highly Sensitive Detection and Dynamic Monitoring of ALK/ROS1 Rearrangement in NSCLC Patients (2161) Yazhen Zhu, Sangjun Lee, Xirun Zheng, Guangjuan Zheng, Hsian-Rong Tseng, Shuang Hou. Guangdong Provincial Hospital of TCM, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; California NanoSystems Institute, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, CA. 11:45 Comparative Evaluation of Alternative Bone Marrow Specimen Types for Targeted Next Generation Sequencing (2117) Sarah Carroll, Molly Accola, William Rehrauer, David Yang. University of Wisconsin School of Medicine and Public Health, Madison, WI. 12:00 BREAK CC 302 SECTION G PULMONARY CHAIRED BY: SANJA DACIC AND JENNIFER M BOLAND 8:00 Pulmonary Ciliated Muconodular Papillary Tumor (CMPT) with Classic and Non-Classic Morphology: Expanded Morphologic and Molecular Spectrum of Bilayered Lesions with Bronchiolar-Type Differentiation (1903) Jason C Chang, Joseph Montecalvo, Shaohua Lu, Dean Wallace, Wichit Sae-Ow, Laetitia Borsu, Hyunjae R Kim, Marc Ladanyi, William Travis, Natasha Rekhtman. MSKCC, NY, NY; UCLA, LA, CA. 111

172 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:15 Reproducibility in Classification of Small Lung Adenocarcinomas: An International Interobserver Study (1993) Angela Shih, Hironori Uruga, Alona Muzikansky, Emine Bozkurtlar, Jin-Haeng Chung, Lida Hariri, Yuko Minami, Andre L Moreira, He Wang, Akihiko Yoshizawa, Mari Mino-Kenudson. Massachusetts General Hospital, Boston, MA; Marmara University, Istanbul, Turkey; Seoul National University, Bundang Hospital, Seongnam, Republic of Korea; National Hospital Organization, Ibarakihigashi National Hospital, Naka, Japan; NYU Langone Medical Center, New York City, NY; Temple University School of Medicine, Philadelphia, PA; Kyoto University Hospital, Kyoto, Japan. 8:30 Next Generation Sequencing Frequently Contradicts Surgical Pathology Impression of Relatedness of Multiple Tumors in the Lung (1932) David H Hwang, Steven J Mentzer, Bruce E Johnson, Lynette M Sholl. Brigham and Women s Hospital, Boston, MA; Dana- Farber Cancer Institute, Boston, MA. 8:45 Histologic Patterns of Lung Cancers Associated with MET Exon 14 Splice Site Alterations (MESSA): A Study of 58 Cases (1953) Joseph Montecalvo, Deepu Alex, Victoria Lai, Mark Kris, Alexander Drilon, Maria E Arcila, Marc Ladanyi, Natasha Rekhtman, William Travis. Memorial Sloan Kettering Cancer Center, New York, NY. 9:00 MET Exon 14 Splicing Mutations and Intragenic Deletions in Non-Small Cell Lung Cancer: A Study of Co-Occurring Genomic Mutations and Copy Alterations (1896) Deepu Alex, Joseph Montecalvo, William Travis, Maria E Arcila, Marc Ladanyi. Memorial Sloan Kettering Cancer Center, New York, NY. 9:15 GNAS Mutations in Mucinous and Non-Mucinous Lung Carcinomas (1977) Lauren Ritterhouse, Marina Vivero, Mari Mino- Kenudson, Lynette M Sholl, John Iafrate, Valentina Nardi, Fei Dong. Brigham and Women s Hospital, Boston, MA; Massachusetts General Hospital, Boston, MA. 11:00 INSM1 Demonstrates Superior Performance to Synaptophysin, Chromogranin, and CD56 for Diagnosis of Thoracic Neuroendocrine Tumors (1979) Lisa M Rooper, Rajni Sharma, Qing K Li, Peter Illei, William H Westra. Johns Hopkins Hospital, Baltimore, MD. 11:15 Are All PD-L1 Antibodies Created Equal? A Multiinstitutional Survey of FDA- and Non FDA-Cleared Immunohiostchemistry Assays on 157 NSCLC Cancers (2007) Hadi Yaziji, Judy Pang, Dafydd G Thomas, Clive R Taylor, Jeffrey L Myers. Vitro Molecular Laboratories, Miami, FL; University of Michigan, Ann Arbor, MI; University of Southern California, Los Angeles, CA. 11:30 SMARCA4 Loss in Lung Cancer Is Associated with Distinct Clinicopathologic Features (1926) Carolyn H Glass, Amanda J Redig, Yin P Hung, Christopher French, Lynette M Sholl. Brigham and Women s Hospital, Boston, MA; Dana- Farber Cancer Institute, Boston, MA. 11:45 SMARCA4/BRG1 Loss Occurs in Mediastinal and Pleural Tumors with Rhabdoid Morphology and Aggressive Behavior (1986) Jennifer L Sauter, Rondell Graham, Anja C Roden, Jennifer M Boland. Mayo Clinic, Rochester, MN. 12:00 BREAK CC 303 SECTION H POTPOURRI CHAIRED BY: JENNIFER O BLACK AND SARANGARAJAN RANGANATHAN 8:00 Comprehensive Genomic Profiling of Pediatric Gliomas Identifies Hypermutated Tumors with Mutations in DNA Mis-Match Repair Genes (1880) Adrienne Johnson, Laurie M Gay, Jo-Anne Vergilio, Julia A Elvin, James Suh, Garrett Frampton, Siraj M Ali, Vincent Miller, Philip Stephens, Jeffrey Ross, John Crawford, Shakti Ramkissoon. Foundation Medicine, Inc, Cambridge, MA; University of California San Diego, San Diego, CA. 8:15 MDR3 and MRP1 Overexpression Are Poor Prognosis Markers in Wilms Tumor Patients After SIOP Standard Treatment Protocol (1870) Enrique de Alava, Lourdes Hontecillas, Daniel J García- Domínguez, Diego Pascual-Vaca Gumez, Rosa García- Mejías, Gema L Ramirez-Villar, Carmen Saez. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Pediatric Oncology Unit, Hospital Universitario Virgen del Rocío, Sevilla, Seville, Spain. 112

173 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:30 Clear Cell Sarcoma of Kidney Is Characterized by BCOR Gene Abnormalities Including Exon 16 Internal Tandem Duplications and BCOR-CCNB3 Gene Fusion (1869) Kenneth Chang, Meng Kang Wong, Sze Jet Aw, Cedric Ng, Vikneswari Rajasegaran, Derrick Lian, Chik Hong Kuick, Jain Sudhanshi, Eva Loh, Amos Loh, Minzhi Yin, Angela Goytain, Tony Ng, Bin Tean Teh. KK Women s and Children s Hospital, Singapore, Singapore; National Cancer Centre Singapore, Singapore, Singapore; Shanghai Children s Medical Centre, Shanghai, China; University of British Columbia, Vancouver, Canada; Vancouver General Hospital, Vancouver, Canada; Duke-NUS Medical School, Singapore, Singapore. 8:45 PHOX2B Reliably Distinguishes Neuroblastoma from Histologic Mimics (1884) John P Lee, Yin P Hung, Andrew M Bellizzi, Jason L Hornick. Brigham and Women s Hospital, Harvard Medical School, Boston, MA; University of Iowa, Iowa City, IA. 9:00 Closing the Loop: Improving Feedback Using LIS Based Reports for Resident Specific Practice Data (553) Matthew Keeney, Amelia Fierro-Fine, Daniel J Pelletier, Chris Jensen. University of Iowa Hospitals and Clinics, Iowa City, IA. 9:15 Cytology Cases of the Week: Five Years of Data on an Educational Tool That Improves Trainee Exposure to Cytology (546) Nhu Thuy Can, Sarah Calkins, Britt-Marie Ljung, Elham Khanafshar, Kristie L White. University of California, San Francisco, San Francisco, CA. 11:00 Digital Image Simulation Training for Cervical Cancer Screening in Low Resource Settings (547) Zelma Cason, Rhonda Alexander, Kim R Geisinger, Marcus D Williams, Stephen Raab. University of Mississippi Medical Center, Jackson, MS. 11:15 Cystoisospora Infection of Gallbladder in Immunocompetent Patients: A Study of 1000 Consecutive Cholecystectomy Specimens (1568) Aysha Mubeen, Amal Shukri, Ahmad Alkhasawneh, Manuel Menes, Carmela Monteiro, Arun Gopinath. University of Florida College of Medicine, Jacksonville, FL. 11:30 Frozen Sections Are Unreliable for the Diagnosis of Necrotizing Soft Tissue Infections (1576) Isaac Solomon, Rene Borscheid, Alvaro C Laga, Reza Askari, Scott R Granter. Brigham and Women s Hospital, Boston, MA. 11:45 Minimally Invasive Autopsy for Cause of Death Determination in Stillbons and Neonates (1573) Jaume Ordi, Paola Castillo, Miguel J Martinez, Dercio Jordao, Lucilia Lovane, Carla Carrilho, Mamudo R Ismail, Cesaltina Lorenzoni, Jordi Vila, Quique Bassat, Clara Menendez. Institute for Global Health (ISGloblal), Hospital Clinic, Universitat de Barcelona, Barcelona, Spain; Hospital Central de Maputo, Universidade Eduardo Mondlane, Maputo, Mozambique. 12:00 BREAK POSTER SESSION I Monday, March 06, :30 AM 12:00 PM Exhibit Hall 1 STOWELL-ORBISON AWARD POSTERS: AUTOPSY 1 Lethal Fetal and Neonatal Alloimmune Thrombocytopenia A Case Report and Review of the Literature (6) Ding Dai, Qi Cai, Christy Isler, Karen Kelly. Brody School of Medicine at East Carolina University, Greenville, NC. 2 Autopsy Findings in Leigh-Like Syndrome Associated with a Novel EARS2 Mutation (17) Li Lei, Jeremy Deisch, Craig Zuppan. Loma Linda University Health, Loma Linda, CA. 3 Foreign Body in Sigmoid Colon, What Else Can Go Wrong? (18) Renuka Malenie, Lisa Leone, Mary Gilliland. Brody School of Medicine/Vidant Medical Center, Greenville, NC; Brody School of Medicine at East Carolina University, Greenville, NC. 4 Follicular Dendritic Cell Sarcoma Lessons from an Aggressive Example at Autopsy (16) Jeremiah Karrs, Amanda Gohlke, Andrew Poklepovic, Andre Oliveira, Hope Richard, Steven C Smith. Virginia Commonwealth University Health System, Richmond, VA; Mayo Clinic, Rochester, MN. 5 Acute Esophageal Necrosis (AEN): A Large Autopsy Study with Emphasis on Its Association with Diabetic Ketoacidosis (DKA) (25) Benjamin D Ramos, Brittany B Coffman, Emily Wolak, Hannah A Kastenbaum, Lori A Proe, Joshua A Hanson. University of New Mexico, Albuquerque, NM. 6 Autopsy Review of Lymphoma Patients Including Clinically Unsuspected Cases: 20 Year Retrospective Study (20) Aysha Mubeen, Ahmad Alkhasawneh. UF Health Jacksonville, Jacksonville, FL. 113

174 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall 1 7 Transformation of Cerebellar Pilocytic Astrocytoma in a Pregnant Woman with Neurofibromatosis Type I (29) Michelle Stoffel, Molly Accola, William Rehrauer, M Shahriar Salamat. University of Wisconsin School of Medicine and Public Health, Madison, WI; University of Wisconsin Hospital and Clinics, Madison, WI. 14 YAP1 Expression in Different Subtypes of Rhabdomyosarcoma (85) Ahsan Siddiqi, Sultan Habeebu, Maria Tsokos, Atif Ahmed. University of Missouri Kansas City, Kansas City, MO; Children s Mercy Hospital, Kansas City, MO; Beth Israel Deaconess Medical Center, Boston, MA. 8 Value of Hospital Autopsy in Solid Organ Transplantation Deaths: A 5 Year Retrospective Study (5) Rachana Choksi, Xu Zeng, Nahum Duker, Abir Mukherjee. Temple University Hospital, Philadelphia, PA. 9 Iatrogenic Hydrophilic Polymer Emboli Following Endovascular Procedures: A Potentially Fatal Complication (10) Tyler BM Hickey, Avrum J Ostry, Jason B Chew, James Caldwell, Michael A Seidman, Hamid Masoudi, John A Maguire. University of British Columbia, Vancouver, BC, Canada; Vancouver General Hospital, Vancouver, BC, Canada; St. Paul s Hospital, Vancouver, BC, Canada. 10 Fatal Aortic Dissection: An 8-Year Retrospective Review of Forensic Autopsy Cases at the West Tennessee Regional Forensic Center: (4) Jinjun Cheng, Zachary O Neill. The University of Tennessee Health Science Center, Memphis, TN; West Tennessee Regional Forensic Center, Memphis, TN. 11 The Value of Autopsy in Solid Organ and Stem Cell Transplant Patients (28) Jeremy Shelton, Margaret Compton, Robert Hoffman. Vanderbilt University Medical Center, Nashville, TN. STOWELL-ORBISON AWARD POSTERS: BONE AND SOFT TISSUE PATHOLOGY 12 EWSR1-FLI1 Regulates PAX7 Expression in Ewing Sarcoma (41) Gregory Charville, Wei-Lien Wang, Jason L Hornick, Matt van de Rijn, Alexander J Lazar. Stanford University School of Medicine, Stanford, CA; The University of Texas MD Anderson Cancer Center, Boston, TX; Brigham and Women s Hospital, Boston, MA. 13 Recurrent GNAQ Mutations in Anastomosing Hemangiomas (37) Gregory R Bean, Nancy M Joseph, Ryan Gill, Andrew L Folpe, Andrew E Horvai, Sarah E Umetsu. University of California San Francisco, San Francisco, CA; Mayo Clinic, Rochester, MN. STOWELL-ORBISON AWARD POSTERS: BREAST PATHOLOGY 15 Intraoperative Assessment of Sentinel Lymph Nodes in Breast Cancer Patients Post-Neoadjuvant Therapy (298) Willard Wong, Sharon Nofech-Mozes, Carlos Parra- Herran, Elzbieta Slodkowska, Wedad Hanna, Fang-I Lu. University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 16 BRAF Alterations in Metastatic Breast Cancer (196) Sungeun Kim, Julia A Elvin, James Suh, Jo-Anne Vergilio, Shakti H Ramkissoon, Siraj M Ali, Vincent Miller, Philip Stephens, Laurie M Gay, Jeffrey Ross. Albany Med Col, Albany, NY; Foundation Med, Cambridge, MA. 17 Atypical Hyperplasia Diagnosed on Breast Core Biopsy: Long-Term Follow-Up of Patients Not Upgraded to Carcinoma on Excision (148) Alana R Donaldson, Caitlin McCarthy, Valentina Avkshtol, Shazia Goraya, Holly J Pederson, Charles D Sturgis, Stephen R Grobmyer, Benjamin C Calhoun. Cleveland Clinic, Cleveland, OH. 18 Isolated Atypical Lobular Hyperplasia Diagnosed on Breast Biopsy: Low Upgrade Rate with Long-Term Follow-Up (233) Kristen E Muller, Julie M Jorns. University of Michigan, Ann Arbor, MI. 19 Biomarker Testing Justification in Low Grade In-Situ and Invasive Breast Carcinoma An Opportunity for Substantial Cost Containment: A Retrospective Analysis of 336 Cases (247) Pallavi A Patil, Kamaljeet Singh, C James Sung, Margaret M Steinhoff, Katrine Hansen, M Ruhul Quddus. Women and Infants Hospital and Warren Alpert Medical School of Brown University, Providence, RI. 20 Flat Epithelial Atypia (FEA) in Directional Vacuum- Assisted Biopsy (DVAB) of Breast Microcalcifications: Surgical Excision Is Not Necessary (224) Zulfia McCroskey, Ross A Miller, Carolyn R Herman, Luz A Venta, Jae Ro, Mary R Schwartz, Alberto Ayala, Nour Sneige. Houston Methodist Hospital, Houston, TX. 114

175 ABSTRACTS POSTER POSTER SESSION SESSION I 21 PD-L1 Expression and Intratumoral Heterogeneity Across Breast Cancer Subtypes: An Assessment of 245 Primary and 40 Metastatic Tumors (146) Erik Dill, Elizabeth Thompson, Chelsea Gottlieb, Timothy Bullock, Janet Cross, Kristen Atkins, Alejandro Gru, Anne Mills. University of Virginia, Charlottesville, VA; The Johns Hopkins Hospital, Baltimore, MD. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 29 Comprehensive Genomic Profiling of Metastatic Malignant Phyllodes Tumors of the Breast (238) Sahar Nozad, Christine E Sheehan, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti H Ramkissoon, Siraj M Ali, Alexa Schrock, Vincent Miller, Philip Stephens, Jeffrey Ross. Albany Med Col, Albany, NY; Foundation Med, Cambridge, MA. 22 Analysis of Ezrin and Phospho-Ezrin (Active) as Biomarkers of Invasion and Metastasis in Breast Cancer (257) Kevin Yi Mi Ren, Abdi Ghaffari, Adewale Adeyinka, Jennifer Fish, Riyeon Laura Kim, Victoria Hoskin, Yolanda Madarnas, Sandip Sengupta, Sonal Varma, Bruce Elliott. Queen s University, Kingston, ON, Canada. 23 Assessing the Checkpoint Immune System (PD-L1, CD8 and CD163) in HER2-Positive Invasive Breast Carcinoma and Its Association with Clinical and Pathological Features (180) Yanjun Hou, Hiroaki Nitta, Peter Banks, Anil Parwani, Zaibo Li. The Ohio State University Wexner Medical Center, Columbus, OH; Ventana Medical Systems, Inc., Tucson, AZ. 24 CD4/CD8 Ratio of Tumor-Infiltrating Lymphocytes (TIL) at the Tumor-Host Interface (THI) Has Prognostic Value in Triple Negative Breast Cancer (TNBC) (296) Kai Wang, Tiansheng Shen, Gene P Siegal, Shi Wei. University of Alabama at Birmingham, Birmingham, AL. 25 Clinical Interplay Between Deubiquitinase 3 (Dub 3) and Snail1 in Breast Cancer (150) Jing Du, Kurt Hodges, Reed Spaulding, Rachel L Stewart, Dehong Li, Yadi Wu, Qiuying Shi. The University of Kentucky, College of Medicine, Lexington, KY. 26 Decrease the Overuse of ER PR Immunohistochemistry Studies in Pure Low Grade Ductal Carcinoma In Situ (DCIS) (181) Jingjing Hu, Farnaz Hasteh. University of California, San Diego, San Diego, CA. 27 Clinicopathologic Findings in Female to Male Gender Reassignment Surgery (151) Ellen G East, Katherine Gast, William Kuzon, Julie M Jorns. University of Michigan, Ann Arbor, MI. 28 Discrepancy Among Oncotype DX Testing, Immunohistochemistry, and Fluorescence In-Situ Hybridization Methods in Evaluating Breast Cancer Biomarker Status (216) Suzanna J Logan, Chao Zhang, Yuan Liu, Momin T Siddiqui, Cynthia Cohen, Xiaoxian Li. Emory University, Atlanta, GA. 30 Breast Cancer Histologic Grade and Histologic Subtype Impact Recurrence Score; Retrospective Review of 863 Oncotype Dx Results (176) Xin He, Elizabeth T Kalife, Shahrzad Ehdaivand, Yihong Wang, C James Sung, Kamaljeet Singh. Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI; Alpert Medical School of Brown University and Women and Infants Hospital of Rhode Island, Providence, RI. 31 Reflex Alternate Reference Probe D17S122 in Double (IHC and FISH) Equivocal Invasive Breast Carcinomas May Aid in Establishing True HER2 Status (166) Brannan Griffin, Jennifer Pincus, Kalliopi P Siziopikou, Luis Z Blanco. Northwestern University, Feinberg School of Medicine, Chicago, IL. 32 GATA3 Is Negative in Endosalpingiosis: A Useful Marker in Distinguishing Metastatic Breast Carcinoma from a Benign Mimicker (297) Marissa White, Russell Vang, Rajni Sharma, Pedram Argani, Ashley Cimino-Mathews. Johns Hopkins Hospital, Baltimore, MD. 33 OncotypeDx and Prosigna in Breast Cancer Patients with a Predominantly Intermediate Recurrence Score: A Comparison Validation Study (290) Pardis Vafaii, Sonia Rodriguez, Alvaro Moreno, Aziza Nassar. Mayo Clinic, Jacksonville, FL. 34 Prognostic Significance of PD-1/PDL-1 Expression in Breast Cancer and Tumor Associated Immune Cells (209) Xin Li, Jose P Leone, Kate Serdy, Binara Assylbekova, Kavita R Varma, Beth Z Clark, David J Dabbs, Rohit Bhargava. Magee Womens Hospital of UPMC, Pittsburgh, PA; University of Iowa, Iowa City, IA. 35 Gene Expression Analysis of Immune Response in Triple Negative Breast Carcinomas Among Different Ethnic Groups (188) Deborah Jebakumar, Di Ai, Bryan Guillory, Jian He, Kimberly Walker, Arundhati Rao. Baylor Scott & White Health, Temple, TX; MD Anderson Cancer Center, Houston, TX. 36 Artefactual Displacement of Ductal Carcinoma In Situ (ADDCIS): A Mimicker of Invasive Carcinoma (266) Maryam Shabihkhani, Ashley Cimino-Mathews, Jean F Simpson, Pedram Argani. Johns Hopkins Medical Institutions, Baltimore, MD; Breast Pathology Consultants, Inc., Nashville, TN. 115

176 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall 1 37 Patients with Breast Cancer and Non-BRCA Mutations: A Clinicopathologic Correlation (101) Indu Agarwal, William Watkin, Peter J Hulick, Megan E Sullivan. NorthShore University HealthSystem, Evanston, IL. 38 TSC2 Gene and Protein as a Biomarker for Primary and Metastatic Breast Cancer (132) Vaibhav Chumbalkar, Sungeun Kim, Israel Kasago, Ann Boguniewicz, Christine E Sheehan, Jeffrey Ross. Albany Med Col, Albany, NY. 39 BRD4 Expression in Lymph Node Negative Breast Cancer: Correlation with T-bet+ Tumour Infiltrating Lymphocytes and Disease Free Survival (280) Farnoosh Tayyari, Minji Lee, Dushanthi Pinnaduwage, Anna Marie Mulligan, Irene Andrulis. University Health Network, Toronto, ON, Canada; Sinai Health System, Toronto, ON, Canada. 40 Characterization of a Novel Immunohistochemical Antibody Against HER-2 with Neutralizing Properties (114) Eva M Bashover, Maureen G Mancini, Adam T Szafran, Dean P Edwards, Michael A Mancini, Alejandro Contreras. U.T. M.D. Anderson Cancer Center, Houston, TX; Baylor College of Medicine, Houston, TX. 41 PDL-1 (Clone 22C) Stromal Expression Predicts Better Overall Survival in HER2+ Breast Carcinoma (211) Yanchun Li, Hossam Jabbour, Xuan Peng, Song Yao, Mateusz Opyrchal, Li Yan, Thaer Khoury. Roswell Park Cancer Institute, Buffalo, NY. 42 The Role of Integrin avβ6 and MMP9 in Aggressive Clinical Behavior in Invasive Micropapillary Breast Carcinoma (IMPC) (168) Hua Guo, Sudarshana Roychoudhury, Silvat S Fayyaz, Sujata Sajjan, Karen M Kostroff, Tawfiqul A Bhuiya. Department of Pathology, Northwell Health, NY; Department of Surgery, Northwell Health, NY. STOWELL-ORBISON AWARD POSTERS: CARDIOVASCULAR PATHOLOGY 43 S100a1 Levels Predict Cardiac Functional Recovery After LVAD Implantation (312) Baidarbhi Chakraborty, Eman Hamad, Theodore Vasiliadis, Rachana Choksi, Shiguang Liu, Linda Mamone, Nirag Jhala, He Wang. Temple University Hospital, Philadelphia, PA. 44 Sudden Death in Hypertrophic Cardiomyopathy. Data from a Large Pathology Registry (326) Joseph Westaby, Mary N Sheppard. St George s University of London, London, United Kingdom. STOWELL-ORBISON AWARD POSTERS: CYTOPATHOLOGY 45 Fine Needle Aspiration Detection of High Grade Dysplasia in Neoplastic Mucinous Cysts of the Pancreas (390) Jason Kern, Roghayeh Fazeli, Lames Lee, Anne Marie O Broin, Syed Z Ali, Christopher VandenBussche. Johns Hopkins University School of Medicine, Baltimore, MD; Boston University SOM, Boston, MA; Banner University Medical Center Tucson, Tucson, AZ. 46 Implementing NIFTP May Potentially Impact the Risk of Malignancy for Thyroid Nodules Categorized as FLUS and SFN (401) Weihong Li, Brian Smola, Judy Pang, Madelyn Lew, Andrew Sciallis, Xin Jing. The University of Michigan, Ann Arbor, MI. 47 Risk of Malignancy in Pancreatic Cysts with High-Grade Atypical Cytology (378) Raza S Hoda, Ronald Arpin, Matthew W Rosenbaum, Martha B Pitman. Massachusetts General Hospital, Boston, MA. 48 ThyroSeq Testing for Indeterminate Thyroid Nodules: An Institutional Experience (358) Natasha Darras, Shweta Agarwal, William C Faquin, Helen H Wang, Barry A Sacks, Michiya Nishino. Beth Israel Deaconess Medical Center, Boston, MA; Massachusetts General Hospital, Boston, MA. 49 Characteristic Cytology of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Implications for Patient Management in the Wake of a Nomenclature Change (349) Jocelyn B Chandler, Glenda G Callender, Courtney E Quinn, Manju L Prasad, Adebowale Adeniran. Yale School of Medicine, New Haven, CT. 50 Mutational Panel Performance in Cytologically- Indeterminate Thyroid Nodules (389) Rachel Jug, Grant Harrison, Michael Datto, Xiaoyin Sara Jiang. Duke Health, Durham, NC. 51 Rare and Multi-Viral High-Risk HPV Infection in Cervical Glandular Lesions: What Did the ThinPrep Pap Test Diagnoses Show? (360) Berlly L Diaz-Gomez, Whitney A McCarthy, Joyce Ou, Cherie Paquette, Katrine Hansen, C James Sung, M Ruhul Quddus. Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI; Clínica Universitaria Colombia-Grupo de Investigación INPAC, Bogota DC, Cundinamarca, Colombia. 52 Usefulness of Liquid-Based Oral/Oropharyngeal Cytology and HPV-Detection for Squamous Cell Carcinoma and Monitoring Treatment Response (359) Jorge de la Oliva, Silvia Alos, Rania Kilzieh, Paula Mackers, Carla Fuster, Francisco Perez, Leonardo Rodriguez, Isabel Vilaseca, Carles Marti, Lucia Alos. Hospital Clinic, Barcelona, Spain. 116

177 ABSTRACTS POSTER POSTER SESSION SESSION I 53 Clinical Outcomes in Patients with Atrophic Pap Smears and Concurrent Positive HPV Testing (416) Zhen W Mei, Tatjana Antic, Ward Reeves, Ricardo R Lastra. University of Chicago Medical Center, Chicago, IL. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 61 Investigating Molecular Profiles in Residual Needle Rinses from Thyroid FNA Specimens (369) Maren Fuller, Dina Mody, April M Hull, Kristi Pepper, Heather Hendrickson, Randall Olsen. Houston Methodist, Houston, TX. 54 Double Staining: The Diagnostic Utility in Non-Small Cell Lung Carcinoma in an Era of Tissue Conservation (365) Abdulwahab Ewaz, Cynthia Cohen, Momin T Siddiqui. Emory University School of Medicine, Atlanta, GA. 55 Next Generation Sequencing Adds Value to Cytology and Fluorescence In Situ Hybridization in the Diagnosis of Bile Duct Brushing Specimens (438) Matthew W Rosenbaum, Jonathan S England, Raza S Hoda, Ronald Arpin, Long Le, David G Forcione, Anthony Iafrate, Martha B Pitman. Massachusetts General Hospital, Boston, MA. 56 Inter-Institutional Variability for Malignancy in Suspicious Salivary Gland Fine Needle Aspiration: A Multi-Institutional Study (336) Seyedeh Elham Arab, Zahra Maleki, Huaqing Zhao, Esther Diana Rossi, Ping Bo, Ashish Chandra, Aatika Malik, Nirag Jhala, Syed Z Ali, Guido Fadda, Viren Patel, Jindong Wang, He Wang. Temple University Hospital, Philadelphia, PA; The Johns Hopkins Hospital, Baltimore, MD; The Catholoc University of Rome, Rome, Italy; Fudan University Cancer Hospital, Shanghai, China; Guy s & St Thomas s Hospital NHSFT, London, United Kingdom. 57 Fluorescence In-Situ Hybridization of Thyroid Fine Needle Aspiration Biopsy Distinguishes Neoplastic and Non-Neoplastic Hurthle Cells (342) Scott Bibbey, Brian Collins. Washington University in St. Louis, St. Louis, MO. 58 Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can an Accurate Diagnosis Be Made on Fine Needle Aspiration (FNA)? (402) Mohammed T Lilo, Christopher J VandenBussche, Neda Rezaee, James Lee, Derek Allison, Amy G Zhou, Sara Mustafa, Barbara Rosenthal, Juliana DeLuca, Jen- Fan Hang, Justin A Bishop, Syed Z Ali. Johns Hopkins Medical Institutions, Baltimore, MD. 59 Follow-Up of Unsatisfactory Pap Tests: Does High- Risk HPV Co-Testing Contribute to Disease Risk Stratification? (483) Lindsay Yassan, Tatjana Antic, Ward Reeves, Ricardo R Lastra. University of Chicago, Chicago, IL. 60 Microfollicular Pattern and Absence of Pseudoinclusions Are Common Cytologic Characteristics in Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features (387) Andrew D Jones, Yanhong Zhang, Alaa Afify, Eric C Huang. University of California Davis Medical Center, Sacramento, CA. 62 Cytologic Study of Atypical Squamous Cells of Unknown Significance (ASCUS) on ThinPrep Liquid Based Cytology and Relationship to High Risk HPV (HRHPV) Status (410) Zhichun Lu, Lauren Noyes, Gary Cole, Daniel Schultz, Gaba Arthur, Ziying Zhang. Henry Ford Health System, Detroit, MI. 63 Targeted KRAS Amplification in Matched Fine-Needle Aspirates (FNA) and Resections of Pancreatic Ductal Adenocarcinoma (PDAC): A Model for Comparing Tumor Source and Tumor Area to DNA Yield (377) Christopher Hartley, Aparna Mahajan, Suzanne Selvaggi, William Rehrauer. University of Wisconsin Hospital and Clinics, Madison, WI. 64 Correlation of Cytopathology with Flow Cytometry and/or Histopathology for Diagnosis of Cervical Lymphadenopathy in Young Adults (354) Bonnie Choy, Ricardo R Lastra, Jeffrey Mueller, Namrata Setia, Ward Reeves, Tatjana Antic. University of Chicago, Chicago, IL. 65 Can Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Classical Papillary Thyroid Carcinoma (PTC) Be Distinguished by Fine Needle Aspiration (FNA)? (343) Tamar C Brandler, Fang Zhou, Margaret Cho, Ryan P Lau, Cheng Liu, Aylin Simsir, Kepal N Patel, Wei Sun. New York University Langone Medical Center, NY, NY. 66 Inter-Institutional Variability of Atypical Salivary Gland Fine Needle Aspiration: A Multi-Institutional Study (411) Aatika Malik, Zahra Maleki, Huaqing Zhao, Esther Diana Rossi, Ping Bo, Ashish Chandra, Seyedeh Elham Arab, Nirag Jhala, Syed Z Ali, Guido Fadda, Jindong Wang, Viren Patel, He Wang. Temple University Hospital, Philadelphia, PA; The Johns Hopkins Hospital, Baltimore, MD; The Catholoc University of Rome, Rome, Italy; Fudan University Cancer Hospital, Shanghai, China; Guy s & St Thomas s Hospital NHSFT, London, United Kingdom. 67 Feasibility and Utility of Cytology Based Next Generation Sequencing for Metastatic Melanoma (424) Laila Nomani, Kelsey McHugh, Yu-Wei Cheng, Jordan P Reynolds, Jennifer Ko. Cleveland Clinic, Cleveland, OH. 68 Orthopedia Homeobox (OTP) Is Preferentially Expressed in Typical Carcinoids of the Lung (362) Zachary Dureau, Gabriel Sica, Cynthia Cohen, Taofeek K Owonikoko, Krisztina Z Hanley. Emory University School of Medicine, Atlanta, GA. 117

178 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall 1 69 The Role of Repeat Endoscopic Ultrasound-Guided Fine Needle Aspiration for Suspected Pancreatic Malignancy (471) Ramona Untanu, Kamal K Khurana. SUNY Upstate Medical University, Syracuse, NY. 70 Molecular Testing in Small Metastatic Colorectal Carcinoma Samples (414) Kelsey McHugh, Laila Nomani, Lani K Clinton, Yu-Wei Cheng, Thomas Plesec, Jordan P Reynolds. Cleveland Clinic Foundation, Cleveland, OH. 71 Follow Up Outcomes of hrhpv Positive Women with Negative versus ASC-US Cytology (334) Josephine S Aguilar-Jakthong, Opal L Reddy, Jill Borer, Po Chu Fung, Jianyu Rao. University of California, Los Angeles, Los Angeles, CA. 72 Analysis of the Atypia of Undetermined Significance/ Follicular Lesion of Undetermined Significant (AUS/ FLUS) Category Experience from a Large Health System (463) Rachel Swarrow, Fan Lin, Haiyan Liu. Geisinger Medical Center, Danville, PA. 73 Comparing the Histologic Follow-Up Results for Women with Negative Cytology and High Risk HPV Positive Pap Smears Using the Hybrid Capture II, Cervista and Aptima hrhpv Assays in a Large Academic Women s Hospital (459) Michelle Stram, Jansen Seheult, Dinesh Pradhan, Chengquan Zhao. UPMC Magee Women s Hospital, Pittsburgh, PA. 74 Lymphoid Enhancer Binding Factor 1 (LEF1) and Paired Box Gene 8 (PAX8): A Limited Immunocytochemistry Panel to Distinguish Solid Pseudopapillary Neoplasms and Pancreatic Neuroendocrine Tumors on Endoscopic Ultrasound-Guided Fine-Needle Aspirates of the Pancreas (409) Haiyan Lu, Jennifer A Brainard, Daniela Allende, Xiuli Liu, Yaxia Zhang. Cleveland Clinic Foundation, Cleveland, OH; University of Florida, Gainesville, FL. 75 Does the Fear of Overcalling Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Result in Changes in the Cytopathologists Use of the Positive (POS) and Suspicious (SUS) for Papillary Carcinoma Diagnostic Categories in Thyroid Fine Needle Aspiration (FNA)? Observations from an Academic Medical Center (445) Samah Saharti, Stefan Pambuccian, Mohammad Atieh, Guliz Barkan, Eva M Wojcik, Swati Mehrotra. Loyola University Health System, Maywood, IL. 76 A Proposed Scoring System to Increase the Specificity of the Diagnosis of Positive for Papillary Thyroid Carcinoma in Fine Needle Aspiration Specimens (351) Hannah H Chen, Hui Zhang, Gamez G Roberto, Stefan Pambuccian, Swati Mehrotra. Loyola University Medical Center, Maywood, IL. STOWELL-ORBISON AWARD POSTERS: DERMATOPATHOLOGY 77 Merkel Cell Carcinoma Has a High of Neoantigens but Low PD-L1 Expression (498) Tiffany Chen, Chang Liu, Weng-Onn Lui, Haley Abel, Eric Duncavage. Washington University School of Medicine, St. Louis, MO; Karolinska University, Stockholm, Sweden. 78 BRAF V600E Mutation and P16 Expression of Melanoma in Nigerians: A 10 Year Retrospective Study (528) Omobolade Obadofin, Kabir Badmos, Nicholas Orsi, Bipin Mathew, Olorunda Rotimi, Adekumbiola Banjo. Lagos University Teaching Hospital, Idi Araba, Nigeria; St James s University Hospital, Leeds, United Kingdom. 79 Factors Affecting Accuracy of Clinical Diagnosis of Suspected Cutaneous Melanomas, a 5-Year Retrospective Study of 17,669 Melanomas (515) Elizabeth Keiser, Thaddeus Mully, Al Naklowycz, Michael Keiser, Mary-Margaret Chren, Eleni Linos. University of California, San Francisco, San Francisco, CA; University of California, San Francisco, CA. 80 Immunohistochemistry Reveals an Increased Proportion of c-myc-positive Cells in a Subset of Subcutaneous Panniculitis-Like T-cell Lymphomas (502) Sebastian Fernandez-Pol, Danielle De Stefano, Jinah Kim. Stanford University, Stanford, CA. 81 Targeted NGS on Primary and Metastatic Malignant Melanoma (541) Chun-Hui Yi, David Y Zhang, Fei Ye. Mount Sinai Medical Center, New York CIty, NY. 82 MET Gene High Copy (Amplification/ Polysomy) Identified in Melanoma for Potential Targeted Therapy (529) Nisha S Ramani, Xiaobing Deng, Jamie Tull, Shengle Zhang. SUNY Upstate Medical University, Syracuse, NY. 83 Nuclear BRAF V600E : Its Clinical Significance as a Prognostic Marker for Melanoma Aggressiveness (527) Robert F Moore, Michael Lee, Andrew B Sholl, Zaid Al-Qurayshi, Mohamed Hassan, Alun R Wang, Emad Kandil. The Johns Hopkins Medical Institutions, Baltimore, MD; Tulane University School of Medicine, New Orleans, LA. 84 Expression of PD-L1 in Extramammary Paget Disease: Implications for Immune-Targeted Therapy (525) Shakuntala Mauzo, Victor G Prieto, Alan E Siroy, Doina Ivan, Michael T Tetzlaff, Priyadharsini Nagarajan, Denai Milton, Jonathan L Curry, Carlos A Torres-Cabala, Phyu P Aung. UT MD Anderson Cancer Center, Houston, TX. 118

179 ABSTRACTS POSTER POSTER SESSION SESSION I 85 Utility of a Next-Generation Sequencing Panel in Myeloid Cutaneous Lesions: A Novel Approach in Distinguishing Leukemia Cutis from Nonneoplastic Myeloid Infiltrates (510) Parsa Hodjat, Martin P Fernandez, Riyam Zreik, Linden Morales, Kimberly Walker, Marcus R Volz, Arundhati Rao. Baylor Scott & White Health, Temple, TX. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 92 Differential Gene Expression Analysis of Invasive and Non-Invasive Follicular Variant of Papillary Thyroid Carcinoma (613) Erik R Washburn, David Goldenberg, Nicole C Williams, Henry Crist, Darrin Bann, Christopher Pool, Elizabeth Cottrill, Max Hennessy, Joshua I Warrick. Penn State Hershey Medical Center, Hershey, PA; Penn State College of Medicine, Hershey, PA. 86 Value of Phospho-S6 Immunostaining in Benign and Malignant Trichofollicular Tumorigenesis (534) Luis A Sardiña, Brian P Rubin, Wilma F Bergfeld. Cleveland Clinic, Cleveland, OH. 87 Tumoral and Peritumoral Immune PD-L1 Expression in Vulvar and Vaginal In Situ and Malignant Melanoma (539) Brian C Willis, Anne Mills, Craig L Slingluff, Alejandro Gru. UVA Department of Pathology, Charlottesville, VA; UVA Department of Oncology, Charlottesville, VA. STOWELL-ORBISON AWARD POSTERS: EDUCATION 88 Using Smartphones to Capture, Share, and Experience Virtual Reality 3D Models for Pathology Education (562) Shyam Prajapati, Julian Samuel, Emilio Madrigal. Mount Sinai Hospital System, New York, NY. STOWELL-ORBISON AWARD POSTERS: ENDOCRINE PATHOLOGY 89 The Utility of FH and SDHB Immunohistochemistry (IHC) in Patients with Clinical Suspicion for Hereditary Paraganglioma-Pheochromocytoma (PGL/PCC) Syndromes (590) Martin J Magers, Aaron Udager, Dayna M Goerke, Michelle L Vinco, Javed Siddiqui, Xuhong Cao, David R Lucas, Jeffrey L Myers, Arul M Chinnaiyan, Thomas J Giordano, Jonathan McHugh, Tobias Else, Rohit Mehra. University of Michigan Health System, Ann Arbor, MI. 90 Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): An Uncommon Diagnosis Lacking BRAF Mutations When Strict Criteria Are Applied (599) Kimberly Point du Jour, Alessandra Schmitt, Christopher C Griffith. Emory University, Atlanta, GA. 91 Phospho-Akt (p-akt) Expression in Thyroid Neoplasms Including the Non-Invasive Follicular Neoplasm with Papillary-Like Nuclear Features (NIFTP) (592) Daniel Matson, Heather Hardin, Ricardo V Lloyd. University of Wisconsin School of Medicine and Public Health, Madison, WI. 93 Oncogenic Roles of Multiple Long Non-Coding RNAs in Papillary Thyroid Carcinoma (618) Ranran Zhang, Heather Hardin, Wei Huang, Darya Buehler, Ricardo V Lloyd. University of Wisconsin School of Medicine and Public Health, Madison, WI. 94 cmyc in Thyroid Follicular Cell-Derived Carcinomas: A Role in Thyroid Tumourigenesis (604) Hany Sakr, Deborah Chute, Christian Nasr, Charles D Sturgis. Cleveland Clinic, Cleveland, OH. 95 Non-Coding RNAs and Phosphorylated Mammalian Target of Rapamycin (p-mtor) Expression in Follicular and Oxyphilic Thyroid Neoplams (575) Adam Covach, Sanjay Patel, Heather Hardin, Ricardo V Lloyd. University of Wisconsin, Madison, WI. 96 Molecular Profile and Cytologic Diagnosis of Non- Invasive Follicular Neoplasm with Papillary-Like Nuclear Features (NIFTP) (606) Maryam Shahi, Hira Yousaf, Faqian Li, Khalid Amin. University of Minnesota, Minneapolis, MN. 97 Expression and Prognostic Significance of Insulinoma- Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) Transcription Factors in Pulmonary Neuroendocrine Neoplasms (605) Michael Schwalbe, Christopher Hartley, Jason N Rosenbaum, Madhuchhanda Roy, Ranran Zhang, Scott W Aesif, Ricardo V Lloyd, Darya Buehler. University of Wisconsin School of Medicine and Public Health, Madison, WI; University of Pennsylvania, Philadelphia, PA. 98 Has the Noninvasive Follicular Thyroid Neoplasm with Papillary Like Nuclear Features Been Seen in the Pediatric Age Group? (586) Ayse Irem Kilic, Hannah H Chen, Iclal Erdem Toslak, Jennifer Lim-Dunham, Guliz A Barkan, Swati Mehrotra. Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey; Loyola University Medical Center, Maywood, IL. 99 Utility of Insulinoma Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Uncommon Neuroendocrine and Neuroepithelial Tumors (602) Madhuchhanda Roy, Ranran Zhang, Ying-Hsia Chu, Michael Schwalbe, M Shahriar Salamat, Ricardo V Lloyd, Darya Buehler, Jason N Rosenbaum. UW, Madison, WI; University of Pennsylvania, Philadelphia, PA. 119

180 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall 1 STOWELL-ORBISON AWARD POSTERS: GASTROINTESTINAL PATHOLOGY 100 Squamoid Morule in the Pseudoinvasive Foci of Colonic Adenomatous Polyp Morphologically Mimics Invasive Carcinoma (721) Hee Eun Lee, Vishal S Chandan, Chung-Ta Lee, Tsung- Teh Wu. Mayo Clinic, Rochester, MN; National Cheng Kung University Hospital, Tainan, Taiwan. 101 Diagnostic Utility of SATB2 in Gastrointestinal Poorly Differentiated Adenocarcinomas with Signet Ring Cells, Pure Signet Ring Cell Carcinomas and Goblet Cell Carcinoids (839) Chen Yang, Lingxin Zhang, Dengfeng Cao. Washington University School of Medicine, St. Louis, MO. 102 Autoimmune Polyendocrinopathy-Candidiasis- Ectodermal Dystrophy (APECED) Associated Gastritis A Variable Phenotype (626) Michael Allgaeuer, Elise MN Ferré, Theo Heller, Michail Lionakis, Martha M Quezado. NCI, NIH, Bethesda, MD; NIDDK, NIH, Bethesda, MD; NIAID, NIH, Bethesda, MD. 103 Gene Expression Profiling in Collagenous Colitis: Toward a Better Understanding of the Disease (729) Qingqing Liu, Huai-Bin Mabel Ko, Hongfa Zhu, Alexandros D Polydorides, Noam Harpaz. Ichan School of Medicine at Mount Sinai, New York, NY. 104 Multinucleated Giant Cells in the Gastroesophageal Junction and Gastric Mucosa (796) Taha Sachak, Wendy L Frankel, Christina A Arnold, Wei Chen. The Ohio State University Wexner Medical Center, Columbus, OH. 105 Genomic Landscape in Appendiceal Goblet Cell Carcinoid: Distinct Profile Compared to Neuroendocrine Tumor and Colorectal Adencoarcinoma (826) Kwun Wah Wen, James Grenert, Nancy Joseph, Nafis Shafizadeh, Mojgan Hosseini, Anne Huang, Sanjay Kakar. UCSF, San Francisco, CA; Kaiser, Woodland Hills, CA; UCSD, San Diego, CA; Vista Pathology, Medford, OR. 106 GATA3 Immunohistochemistry in Adenocarcinoma of the Ampullary Region (783) Sonya Purushothaman, Helen E Remotti, Stephen M Lagana, Susan J Hsiao, Hui-Min Yang. Columbia University, New York, NY. 107 Verrucous Carcinoma of the Esophagus Shares a Methylation Profile with Usual Esophageal Squamous Carcinoma (755) Prasuna Muppa, William R Taylor, Tracy C Yab, Douglas W Mahoney, John B Kisiel, David A Ahlquist, Thomas Smyrk. Mayo Clinic, Rochester, MN. 108 TFE3 and SOX11 as Novel Diagnostic Markers for Solid Pseudopapillary Neoplasms (693) Grant Harrison, Amanda Hemmerich, Diana Cardona, Cynthia Guy, Shannon McCall, Xuefeng Zhang. Duke University Medical Center, Durham, NC. 109 Fibromuscular Strictures in Ileal Crohn s Disease: A Detailed Morphometric and Histopathologic Analysis (843) Xiaofei Zhang, Huai-Bin Mabel Ko, Zhenjian Cai, Hongfa Zhu, Alexandros D Polydorides, Joana Torres, Judy Cho, Bachir Taouli, Noam Harpaz. Icahn School of Medicine at Mount Sinai, New York, NY. 110 Metastatic Breast Carcinoma with Signet-Ring Features versus Gastrointestinal Signet-Ring Tumors: Assessment of Immunohistochemical Markers (700) Yiang Hui, Kara A Lombardo, Murray B Resnick, Yihong Wang. Brown University/Rhode Island Hospital, Providence, RI. 111 Mast Cells in Microscopic Colitis: A Potential Therapeutic Target? (658) Zhikai Chi, Romil Saxena. Indiana University School of Medicine, Indianapolis, IN. 112 EPB41L5 and PDK2 Are Biomarkers of Metastasis in Pancreatic Neuroendocrine Tumors (750) Tania Mendoza, Steven A Eschrich, Kevin Neil, Jonathan R Strosberg, Nasir Aejaz, Domenico Coppola. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Eli Lilly and Company, Indianapolis, IN. 113 Effects of Interobserver Variability and Subspecialty Signout on Diagnosing Microscopic Colitis (804) Meenal Sharma, Christa L Whitney-Miller, Michael G Drage, Aaron R Huber, Raul S Gonzalez. University of Rochester, Rochester, NY. 114 Expression of PD-L1 in Colorectal Carcinoma (CRC) Primarily Occurs in Stromal/immune Cells at Tumor- Stroma Interface (TSI), and Is Associated with High Tumor-Infiltrating Lymphocytes (TILs) Irrespective of the Microsatellite Instability (MSI) Status or the Molecular Mechanism of MSI (732) Sandy Liu, Jaclyn Hechtman, Neil Segal, Joshua Smith, Deepthi Rao, Arnold Markowitz, Martin Weiser, Efsevia Vakiani, David S Klimstra, Zsofia Stadler, Jinru Shia. Memorial Sloan Kettering, NY, NY. 120

181 ABSTRACTS POSTER POSTER SESSION SESSION I 115 Chromogenic In Situ Hybridization (CISH) Based Tracking of Donor Derived Lymphocytes Augments the Histologic Evaluation of Human Acute Graft versus Host Disease (GVHD) (765) Kwadwo Oduro, Kshitij S Arora, Vikram Deshpande. Massachusetts General Hospital, Boston, MA. 116 Deep Inflammation in Clinically Diagnosed Ulcerative Colitis (UC) Resections: How Much Is Too Much? (808) Sharon Song, Stuti G Shroff, Emma E Furth, Rashmi Tondon, Kristen M Stashek. University of Pennsylvania, Philadelphia, PA. 117 Localized Colonic Ischemia Producing a Mass and Clinically Mimicking Colon Carcinoma: An Unrecognized Variant of Ischemic Colitis (774) Smita Patel, Shenon Sethi, Shriram Jakate. Rush University Medical Center, Chicago, IL. 118 TTF-1 Expression Is Upregulated in the Corpus in Autoimmune Atrophic Gastritis (641) Ava Bhattarai, Andrew M Bellizzi. University of Iowa, Iowa City, IA. 119 Gene Expression Profiling of Appendiceal Goblet Cell Carcinoid Tumors (738) Chelsea Maedler, Daniel Gaston, Nourah M Obaid, Thomas Arnason, Karen Bedard, Weei-Yuarn Huang. Dalhousie University, Halifax, NS, Canada. 120 Differentiating the Undifferentiated Revisited: Expression of Markers of Intestinal Differentiation, GPA33, CDX2, CDH17 and SATB2 in Medullary (Undifferentiated) Carcinoma of the Colon (831) Stephanie Wood, Anthony J Gill, Hai Wang, Kenneth Friedman, Kara A Lombardo, Murray B Resnick. Rhode Island Hospital, Providence, RI; OHSU, Portland, OR; Royal North Shore Hospital, St Leonards, Australia. 121 Deep Sequencing of Intrahepatic Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma and Klatskin Tumors (748) Daiva Mattis, Nancy M Joseph, Iwei Yeh, Eric Talevich, Courtney Onodera, Aras N Mattis. University of California San Francisco, San Francisco, CA. 122 Histologic Features in Colorectal Sessile-Shaped Malignant Polyps with Nodal Metastasis (772) Natalie Patel, Romulo Celli, Buqu Hu, Dhanpat Jain, Xuchen Zhang. Yale University, New Haven, CT. 123 Interobserver Variability in the Diagnosis of Inflammatory Bowel Disease-Associated Dysplasia by International Telepathology (654) Michael Chang, Yanfei Huang, Dipti M Karamchandani, Xian-rui Wu, Daniela Allende, John R Goldblum, Shu-Yuan Xiao, Hongfa Zhu, Michael Feely, Amy Collinsworth, Ashwini K Esnakula, Hao Xie, Xiuli Liu. U of Florida, Gainesville, FL; Penn State U, Hershey, PA; Sun Yat-sen U, Guangzhou, China; Cleveland Clinic, Cleveland, OH; U of Chicago, Chicago, IL; Mount Sinai Hosp, New York, NY; Yale U, New Haven, CT. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 124 Gastrointestinal and Pancreatic Findings in Patients with McCune-Albright Syndrome (761) Michaël Noë, Laura D Wood, Wenzel Hackeng, Lodewijk AA Brosens, Feriyl Bhaijee, Marija Debeljak, Jun Yu, Alison Boyce, Cemre Robinson, James R Eshleman, Ralph H Hruban, Michael G Goggins, Michael T Collins, Anne Marie Lennon, Elizabeth A Montgomery. Johns Hopkins University, Baltimore, MD; University Medical Center Utrecht, Utrecht, Netherlands; National Institutes of Health, Bethesda, MD. 125 Programmed Cell Death Ligand -1 (PD-L1) Expression in Gastrointestinal Stromal Tumors Correlates Significantly with Presence of Tumor Infiltrating Lymphocytes (799) Deepika Savant, Taisia Vitkovski, Rebecca Thomas, Arvind Rishi. Hofstra-Northwell Health School of Medicine, Lake Success, NY. 126 Macrophage Aggregation Is a Salient Feature of Acute Rejection in Small Intestinal Allografts (795) Natalia Rush, Chandrashekhar Kubal, Romil Saxena. Indiana University School of Medicine, Indianapolis, IN. 127 Mismatch Repair Deficiency (MMR-D) and Programmed Death Ligand-1 (PD-L1) Expression in Gastric Adenocarcinomas (709) Taylor M Jenkins, Rashmi Tondon, Li-Ping Wang, Amy Ziober, Priti Lal, Stuti G Shroff, Emma E Furth, Kristen M Stashek. University of Pennsylvania, Philadelphia, PA. 128 Definition of Barrett Esophagus in the United States (US): Support for Retention of a Requirement for Goblet Cells (798) Kevan Salimian, Kevin Waters, Ogechukwu Pearl Eze, Maryam Pezhouh, Yaman Tarabishy, Lysandra Voltaggio, Elizabeth A Montgomery. Johns Hopkins Hospital, Baltimore, MD. 129 Prognostic Significance of Tumour Regression Grade at Primary Site and Its Correlation with Clinical and Histological Parameters in Post Chemotherapy Excision Specimens of Oesophagus-Single Institutional Study (634) Ganesh Bahirwade, Shubhada Kane, Rajiv Kumar, Swapnil Rane, Anuj Verma, Kumar Prabhash, Pramesh Shanmugham. Tata Memorial Hospital, Mumbai, India. 130 Two-Stain Rather Than Four-Stain Immunohistochemical Screening in Colorectal Cancer May Fail to Detect Mismatch Repair Deficiency (746) Michael Markow, Rachel Pearlman, Christina A Arnold, Deborah Knight, Heather Hampel, Wendy L Frankel. The Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, OH. 121

182 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall A Crohn s-like Appearance Characterizes Actinomycotic Appendicitis (698) Bela Horvath, Ian Brown, Namrata Setia, Anthony Mattia, Laura W. Lamps, Gregory E Lauwers, Joseph Misdraji. Massachusetts General Hospital, Boston, MA; Envoi Specialist Pathologists, Kelvin Grove, QLD, Australia; University of Chicago, Chicago, IL; University of Arkansas for Medical Sciences, Little Rock, AR; University of California, San Francisco, CA. 137 Comprehensive Genomic Profiling of Small Cell Neuroendocrine Carcinoma of the Urinary Bladder (1015) Aseeb Rehman, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti H Ramkissoon, Siraj M Ali, Alexa Schrock, Sumanta Pal, Hugh A Fisher, Badar Mian, Tipu Nazeer, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Laurie M Gay, Jeffrey Ross. Albany Med Col, Albany, NY; Foundation Med, Boston, MA; City of Hope, Duarte, CA. 132 Neuroendocrine Proliferations in Inflammatory Bowel Disease (830) Mary Wong, Brent Larson, Deepti Dhall. Cedars-Sinai Medical Center, Los Angeles, CA; Keck School of Medicine of the University of Southern California, Los Angeles, CA. STOWELL-ORBISON AWARD POSTERS: GENITOURINARY PATHOLOGY (INCLUDING RENAL TUMORS) 133 Comparison Between Pathologic Findings in Targeted MRI Guided Prostate Needle Core Biopsies and Transrectal Ultrasound Guided Prostate Needle Core Biopsies in Patients with Normal, Enlarged and Markedly Enlarged Prostates (910) Rachel Geller, Sherif G Nour, Kareem Elfatairy, Adeboye O Osunkoya. Emory University Hospital, Atlanta, GA. 134 PTEN and p27 Loss Differ Among Morphologic Patterns of Prostate Cancer (845) Daniel W Abbott, Shira Ronen, Amrou Abdelkader, Anjishnu Banerjee, Yayun Xu, Oleksandr Kravtsov, Ken A Iczkowski. Medical College of Wisconsin, Milwaukee, WI. 135 Genomic Mapping of Primary Unifocal and Multifocal Renal Cell Carcinoma (995) Rebecca C Obeng, Adam Lorentz, Usama Alqassab, Dean Laganosky, Christopher Keith, Fei Lian, Kenneth Ogan, Viraj A Master, John G Pattaras, Michael Rossi, Rebecca Arnold, Jeremy Goecks, John A Petros, Adeboye O Osunkoya. Emory University, Atlanta, GA; Beth Isreal Deaconess Medical Center, Boston, MA; George Washington University, Washington, DC. 136 Pathologic Factors Predicting Higher Clinical Stage in Testicular Seminomas: A Proposal for Upstaging Based on Rete Testis or Hilar Soft Tissue Invasion (1063) Karen Trevino, Alaleh Esmaeili Shandiz, Thomas M Ulbright, Muhammad Idrees. Indiana University School of Medicine, Indianapolis, IN. 138 Application of Clinical-Grade FISH Assays for Identification of MiT Family Translocation-Associated Renal Cell Carcinoma (t-rcc): Clinicopathologic Characteristics and Report of 20 Genetically Confirmed Cases, Including TFEB-Amplified Renal Cell Carcinoma (1050) Stephanie Skala, Aaron M Udager, Yang Zhang, Carrie Landau, Saravana Dhanasekaran, Diane Roulston, Lina Shao, Javed Siddiqui, Xuhong Cao, Steven C Smith, Jesse K McKenney, Jeffrey L Myers, Arul M Chinnaiyan, Hong Xiao, Scott A Tomlins, Rohit Mehra. University of Michigan, Ann Arbor, MI; Virginia Commonwealth University, Richmond, VA; Cleveland Clinic, Cleveland, OH. 139 SOX4 Expression in Prostatic Adenocarcinoma with Matched Lymph Node Metastasis (997) Claudia Ormenisan Gherasim, Anand C Annan, Birdal Bilir, Carlos S Moreno, Adeboye O Osunkoya. Emory University School of Medicine, Atlanta, GA. 140 Re-Evaluation of 31 Unclassified Eosinophilic Renal Cell Carcinomas in Young Patients (961) Yunjie Li, Victor E Reuter, George J Netto, Jonathan I Epstein, Pedram Argani. Johns Hopkins University School of Medicine, Baltimore, MD; Memorial Sloan Kettering Cancer Center, New York, NY. 141 Total Prostate-Specific Antigen (tpsa) Outperformed Free PSA Percentage (fpsa%) in Detecting High-Grade Prostate Cancer (PCa) and PCa in Patients Older Than 60 Years of Age (1052) Tong Sun, Kristine Cornejo, MRabie Al-Turkmani, Lokinedi Rao. University of Massachusetts Medical School, Worcester, MA. 142 Prevalence of TERT Promoter Mutations in Different Morphological Variants of Urothelial Carcinoma and in Basal and Non-Basal Urothelial Carcinoma (1006) Dinesh Pradhan, Wayne Ernst, Stephanie Mercurio, Marina N Nikiforova, Rajiv Dhir, Somak Roy. UPMC, Pittsburgh, PA. 143 Evaluation of RNA ISH Assay for TFE3 Expression in Comparison to IHC and FISH: Do We Have a Third Approach? (932) Kareem Hosny Mohammed, Momin T Siddiqui, Tong Yang, Diane Lawson, Cynthia Cohen. Emory University Hospital, Atlanta, GA. 122

183 ABSTRACTS POSTER POSTER SESSION SESSION I 144 Metastatic Lymph Node Involvement in Anterior Prostatic Fat and Implications for the Pathologist (968) Nicolas Lopez-Hisijos, Iskender Sinan Genco, Alex Gorbonos, Stefan Pambuccian, Guliz Barkan. Loyola University Medical Center, Maywood, IL. 145 Papillary Renal Cell Carcinoma Histological, Immunophenotypical and Molecular Characterization; New Classification System (1024) Rola Saleeb, Fadi Brimo, Fabio Rotondo, Mina Farag, Pamela Plant, George M Yousef. St. Michael s Hospital, Li Ka Shing Knowledge Institute, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; McGill University Health Center, Montreal, QC, Canada. 146 Plasmacytoid Urothelial Carcinoma: A Single Institution Immunohistochemical and Molecular Study of 26 Cases (1003) Carmen Perrino, Liang Cheng, Muhammad Idrees, John N Eble, Chia-Sui Kao, David Grignon. Indiana University, Indianapolis, IN; Stanford University, Stanford, CA. 147 Morphologic and Clinical Comparison of BRCA+ and BRCA- Prostate Carcinoma (857) Amanda Barrett, Lauren E Schwartz. The Hospital of the University of Pennsylvania, Philadelphia, PA. 148 Gleason Score 7 and 8 Prostate Cancer with Cribriform Morphology Diagnosed in Prostate Biopsy Is More Likely to Have Seminal Vesicle Invasion and Pelvic Lymph Node Metastasis in Radical Prostatectomy (1072) Ying Wang, Fang-Ming Deng, Hongying Huang, Peng Lee, Jonathan Melamed, Ming Zhou. New York University Langone Medical Center, New York, NY. 149 A Comparative Study of pt3 versus pt2 Testicular Germ Cell Tumors, Including Evaluation of Lymphovascular Invasion (LVI) in the Spermatic Cord (1032) Joseph Sanfrancesco, Karen Trevino, Adeboye Osunkoya, Guang Q Xiao, Chia-Sui Kao, Jennifer Gordetsky, Pamela Unger, Thomas M Ulbright, Muhammad Idrees. Indiana University, Indianapolis, IN; Emory University, Atlanta, GA; University of Southern California, Los Angeles, CA; UAB, Birmingham, AL; Stanford University, Stanford, CA; Lenox Hill, New York, NY. 150 Infrequent PD-L1 Protein Expression and Gene Amplification in Prostatic Adenocarcinomas (PACs) (992) Saleh N Najjar, Bhaskar VS Kallakury, Christine E Sheehan, Tipu Nazeer, Jeffrey Ross. Albany Medical College, Albany, NY; Georgetown University Hospital, Washington, DC. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 151 Morphologic, Clinical and Molecular Features of Large Cell Neuroendocrine Carcinoma (LCNEC) of the Bladder (985) Leili Mirsadraei, Xueli Hao, Min Yuen Teo, Kuo- Cheng Huang, Ying-Bei Chen, Anuradha Gopalan, Sahussapont Joseph Sirintrapun, Samson W Fine, Satish K Tickoo, Bernard H Bochner, Guido Dalbagni, Dean F Bajorin, Barry S Taylor, David Solit, Gopakumar V Iyer, Victor E Reuter, Hikmat Al-Ahmadie. Memorial Sloan Kettering Cancer Center, NY, NY. 152 Evaluation of Histological Changes in Radical Prostatectomy (RP) After Neoadjuvant Androgen Deprivation Therapy (NeoADT): Comparison Between Conventional and Newer Therapy Regimens (935) Kuo-Cheng Huang, Leili Mirsadraei, Ying-Bei Chen, Sahussapont Joseph Sirintrapun, Hikmat Al-Ahmadie, Samson W Fine, Karim A Touijer, James Eastham, Karen A Autio, Dana E Rathkopf, Satish K Tickoo, Howard I Scher, Victor E Reuter, Anuradha Gopalan. Memorial Sloan Kettering Cancer Center, New York, NY. 153 The Association of Cribriform Lesions with Prostatic Adenocarcinoma Outcomes: A Meta Analysis (970) Xunda Luo, Nirag Jhala, Jasvir S Khurana. Temple University Hospital, Philadelphia, PA. 154 Predictors of Metastatic Disease in Testicular Seminoma: Clinicopathologic Study of 406 Cases (1036) Aylin Sar, Kiril Trpkov, Tina Cheng, Asli Yilmaz. University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada; Tom Baker Cancer Centre, Calgary, AB, Canada. 155 Metastatic Tumors to the Bladder: Avoiding the Diagnostic Pitfall (905) Alexander Feldman, Jennifer Gordetsky. University of Alabama at Birmingham, Birmingham, AL. 156 Pathologic Factors Predicting Higher Clinical Stage in Testicular Non-Seminomatous Germ Cell Tumors (NSGCT): A Proposal for Upstaging Based on Rete Testis or Hilar Soft Tissue Invasion (902) Alaleh Esmaeili Shandiz, Karen Trevino, Thomas M Ulbright, Muhammad Idrees. Indiana University School of Medicine, Indianapolis, IN. 157 Prognostic and Predictive Significance of TSC1/2 in Urothelial Carcinoma of the Bladder (UCB) (1005) Katherine Pinheiro, Aseeb Rehman, Chunlai Zuo, Sanaz Ainechi, Bhaskar VS Kallakury, Christine E Sheehan, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti H Ramkissoon, Siraj M Ali, Alexa Schrock, Sumanta Pal, Hugh A Fisher, Badar Mian, Tipu Nazeer, David Fabrizio, Garrett Frampton, Caitlin Connelly, Vincent Miller, Philip Stephens, Laurie M Gay, Jeffrey Ross. Albany Med Col, Albany, NY; Georgetown University Hosp, Washington, DC; Foundation Med, Cambridge, MA. 123

184 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall Expression of Stearoyl-CoA Desaturase (SCD) Is a New Predictor of Prostate Cancer Progression After Radical Prostatectomy (875) Jinrong Cheng, Bo Xu, Chen Gao, Yingdong Feng, James Mohler, James Marshall. State University of New York at Buffalo, Buffalo, NY; Roswell Park Cancer Institute, Buffalo, NY. 159 Peyronie Disease A Contemporary Interinstitutional Cohort Emphasizing Histopathology (954) Caleb King, Kathryn G Lindsey, Laura Spruill, Steven C Smith. Virginia Commonwealth University School of Medicine, Richmond, VA; Medical University of South Carolina, Charleston, SC. 160 Clinical Significance of Urothelial Papillary Proliferation of Unknown Malignant Potential (UPUMP): A Retrospective Study of 79 Patients (969) Brett M Lowenthal, Mahul B Amin, Donna Hansel. University of California San Diego, San Diego, CA; University of Tennessee Health Sciences Center, Memphis, TN. 161 Non-Invasive Spread of Urothelial Carcinoma (UCa) within Urachal Remnants: An Underecognized Phenomenon with Potential for Overstaging as Muscularis Propria (MP)-Invasive Disease (925) Lisa Han, Gladell P Paner. University of Chicago, Chicago, IL. 162 CD34+ Tubular Basement Membrane in Germ Cell Tumors: Staging Pitfall (914) Amanda Gohlke, Cora Uram-Tuculescu, Susan Pitt, Mahul B Amin, Steven C Smith. Virginia Commonewealth University Health System, Richmond, VA; Cedars-Sinai Medical Center, Los Angeles, CA. 163 Accuracy of PIRADS on Targeted Prostate Needle Core Biopsies: A Single Institutional Radiopathologic Correlation (999) Vamsi Parimi, Ian Hughes, Maria M Picken. Loyola University Medical Center, Maywood, IL. 164 Acquired Cystic Disease-Associated Renal Cell Carcinoma: A Whole Exome Sequencing Pilot Study (1023) Faisal Saeed, Francesca Khani, Weihua Huang, Changhong Yin, Brian Robinson, John T Fallon, Minghao Zhong. New York Medical College at Westchester Medical Center, Valhalla, NY; Weill Cornell Medical College, New York, NY. 165 Correlation of Retrograde Nephroureteroscopy Biopsies with Resections for Presence of Urothelial Carcinoma and Carcinoma Upgrading (906) Shiraz Fidai, Tatjana Antic. The University of Chicago Medical Center, Chicago, IL p21 Amplified Renal Cell Carcinoma: A Distinct Entity with Potential Implications for Clinical Management. (922) Sounak Gupta, Sarah H Johnson, George Vasmatzis, Priya Rao, Brian A Costello, Bradley C Leibovich, R H Thompson, John C Cheville, William R Sukov. Mayo Clinic, Rochester, MN; MD Anderson Cancer Center, Houston, TX. 167 Fluorescent In Situ Hybridization Analysis of Sarcomatoid Carcinoma of the Prostate (1086) Ramin Zargham, William R Sukov, John C Cheville, Rafael E Jimenez. Mayo Clinic, Rochester, MN. STOWELL-ORBISON AWARD POSTERS: GYNECOLOGIC AND OBSTETRIC PATHOLOGY 168 Comparison of Clinicopathological Outcomes for Insufficient and Scant Endometrial Samples (1153) Emily Goebel, Helen Ettler, Meg M McLachlin, Michele M Weir. Western University, London, ON, Canada. 169 Genomic Abnormalities in Invasive Endocervical Adenocarcinoma Correlate with Pattern of Invasion: Biologic and Clinical Implications (1158) Anjelica Hodgson, Yutaka Amemiya, Arun Seth, Matthew Cesari, Bojana Djordjevic, Carlos Parra- Herran. Sunnybrook Health Sciences Centre University of Toronto, Toronto, ON, Canada. 170 HPV E6/E7 RNA In Situ Hybridization Signal Patterns Utility for Cervical Lesion Grading (1115) Britni RE Bryant, Mark Evans, Maureen Harmon, Scott Anderson, Alexandra Kalof. University of Vermont College of Medicine / Medical Center, Burlington, VT. 171 Genomic Copy Profiling of Uterine Malignant Mixed Müllerian Tumor Identifies a Recurrent Focal Amplicon Associated with Sarcomatous Transformation (1126) Michael Herman Chui, Cherry Have, Lien N Hoang, Patricia Shaw, Cheng-Han Lee, Blaise Clarke. Toronto General Hospital, University of Toronto, Toronto, ON, Canada; BC Cancer Agency, Vancouver, BC, Canada. 172 Androgen Receptor Expression in Endometrial Carcinoma (1276) Sara Zadeh, Linda Duska, Kristen Atkins, Anne Mills. The University of Virginia, Charlottesville, VA. 124

185 ABSTRACTS POSTER POSTER SESSION SESSION I 173 Endometrial Serous Carcinogenesis in a Transgenic Mouse Model (1227) Glorimar Rivera-Colon, Li Li, Wenjing Zhang, Setsuko Chambers, Beihua Kong, Wenxin Zheng. University of Texas Southwestern Medical Center, Dallas, TX; Shandong University, School of Medicine, Jinan, Shandong, China; Qilu Hospital, Shandong University, Jinan, Shandong, China; University of Arizona, Tucson, AZ. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 181 Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in a Multi-Institutional Cohort of 165 Cases (1131) MHD Fayez Daaboul, Eman Abdulfatah, Oumaima Chaib, Marcel T Ghanim, Baraa Alosh, David G Mutch, Sean C Dowdy, Sudeshna Bandyopadhyay, Rouba Ali- Fehmi. WSU, Detroit, MI; Washington University, St. Louis, MO; Mayo Clinic, Rochester, MN. 174 Usual Type Endocervical Adenocarcinoma/AIS Incidence and Distribution of High-Risk HPV Genotypes Between and (1205) Whitney A McCarthy, Yiang Hui, Berlly L Diaz-Gomez, Joyce Ou, Cherie Paquette, C James Sung, W Dwayne Lawrence, M Ruhul Quddus. Women and Infants Hospital of Rhode Island/ Warren Alpert Medical School of Brown University, Providence, RI; Clinica Universitaria Colombia--Grupo de Investigacion INPAC, Bogota DC, Cundinamarca, Colombia. 175 PAX8 Expression Occurs in the Setting of BAP1 Loss in Malignant Peritoneal Mesothelioma (1123) David B Chapel, Stephanie M McGregor, Aliya N Husain, Thomas Krausz. University of Chicago, Chicago, IL; University of Wisconsin-Madison, Madison, WI. 176 Implementation of Somatic BRCA Testing for Ovarian Carcinoma in Routine Practice (1107) Beryl Bayol, Frederique Penault-Llorca, Yannick Bidet, Anne Cayre, Mathilde Gay-Bellile, Christophe Pomel, Sandrine Viala, Marie-Ange Mouret-Reynier, Lucie Tixier, Yves-Jean Bignon. Centre Jean Perrin, Clermont Ferrand, France. 177 Prognostic Implications of the Size,, and Location of Lymph Node Metastases in High-Grade Endometrial Carcinomas (1254) Lily Tran, Steven Maron, Ricardo R Lastra. University of Chicago, Chicago, IL. 178 PD-L1 Expression in Mismatch Repair-Deficient Endometrial Carcinomas, Including Lynch Syndrome-Associated and Sporadic MLH1 Promoter Hypermethylated Tumors (1241) Emily A Sloan, Kari Ring, Brian C Willis, Susan C Modesitt, Anne Mills. University of Virginia, Charlottesville, VA. 179 The Immune Microenvironment of Microsatellite Stable Endometrial Carcinomas: Identification of Subsets with Higher PD-L1 Expression (1129) Suzanne Crumley, Michael T Tetzlaff, Katherine Kurnit, Russell R Broaddus. M.D. Anderson Cancer Center, Houston, TX. 180 Clinical Utility of SATB2 in Determining Site of Origin in Abdomino-Pelvic Tumors (1258) Kavita Varma, Jing Yu, Binara Assylbekova, Xin Li, Esther Elishaev, Amal Kanbour-Shakir, Beth Z Clark, David J Dabbs, Rohit Bhargava. Magee-Womens Hospital of UPMC, Pittsburgh, PA. 182 Immune Checkpoint Status and Tumor Microenvironment in Vulvar Squamous Cell Carcinoma (1127) Margaret Cocks, Erik G Jenson, James A Miller, Maria Del Carmen Rodriguez Pena, Aline C Tregnago, Diana Taheri, Rajni Sharma, Russell Vang, George J Netto. Johns Hopkins University, Baltimore, MD. 183 PD-L1 Expression in Tumor-Associated Macrophages in Primary and Metastatic High-Grade Serous Ovarian Carcinoma (1155) Chelsea Gottlieb, Kari Ring, Anne Mills. University of Virginia, Charlottesville, VA. 184 Predictive Histologic Factors in Carcinosarcoma of the Uterus: A Multi-Institutional Study (1094) Eman Abdulfatah, Leonardo Lordello, Muhammad Khurram, Kinda Hayek, Koen Van de Vijver, Lamia Fathallah, Sudeshna Bandyopadhyay, Rouba Ali-Fehmi, Esther Oliva. WSU, Detroit, MI; MGH, Boston, MA; St.J, Detroit, MI. 185 Histomorphologic Study of Exogenous Testosterone Effects on the Ovaries and Uterus of Female to Male Transgender Patients (1095) Ahmed A Abdulrahman, Scott D Richard, Robert T Ownbey, Suganthi Soundararajan. Drexel University College of Medicine, Philadelphia, PA; Hahnemann University Hospital, Philadelphia, PA. 186 Invasive Implants of Ovarian Serous Borderline Tumor: Significant Association with KRAS but Not BRAF Mutation (1281) Tao Zuo, Serena Wong, Natalia Buza, Pei Hui. Yale University, New Haven, CT. STOWELL-ORBISON AWARD POSTERS: HEAD AND NECK PATHOLOGY 187 LEF1 Is S Sensitive Marker of Cribriform Morular Variant of Papillary Thyroid Carcinoma (1322) Shalini Mohindra, Hany Sakr, Charles D Sturgis, Christine N Booth, Deborah Chute. Cleveland Clinic, Cleveland, OH. 188 p16 Expression in Follicular Dendritic Cell Sarcoma: A Potential Mimicker of HPV-Related Squamous Cell Carcinoma (1346) Lingxin Zhang, Chen Yang, James Lewis, Samir K El- Mofty, Rebecca Chernock. Washington University School of Medicine, St. Louis, MO; Vanderbilt University Medical Center, Nashville, TN. 125

186 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall Comprehensive Genomic Profiling of Salivary Gland Myoepithelial Carcinoma (1297) Siddhartha Dalvi, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti H Ramkissoon, Kai Wang, Daniel Bowles, Hilary Somerset, Siraj M Ali, Alexa Schrock, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Laurie M Gay, Jeffrey Ross. Albany Med Col, Albany, NY; Foundation Med, Boston, MA; Univers of Colorado, Denver, CO. 190 Melan-A Expression in Olfactory Neuroblastoma (1301) Amelia Fierro-Fine, Robert Robinson, Anthony Snow. University of Iowa, Iowa City, IA. 191 Is Regional Lymph Nodes Metastasis of Head and Neck Paraganglioma a Sign of Aggressive Clinical Behavior? A Clinical/pathologic Review (1308) Sara Javidiparsijani, Diana Lin, Vijaya B Reddy, Pincas Bitterman, Paolo Gattuso. RUSH University Hospital, Chicago, IL. 192 Usefulness of NKX2.2 Immunohistochemistry in the Sinonasal Small Round Blue Cell Tumor Differential Diagnosis (1319) Austin McCuiston, Justin A Bishop. Johns Hopkins University School of Medicine, Baltimore, MD. 193 Does the Extent of Extracapsular Spread in Lymph Node Metastases Correlate with Outcomes in Oropharyngeal Squamous Cell Carcinoma? A Retrospective Study (1340) Beena Umar, Steve Chang, Tamer Ghanem, Farzan Siddiqui, Gordon Jacobsen, Derek Isrow, Christian E Keller. Henry Ford Hospital (HFH), Detroit, MI. 194 PD-L1 Expression Predicts Improved Disease Free Survival in High Risk Head and Neck Cutaneous Squamous Cell Carcinoma (1330) Edward Roper, Trina Lum, Carsten E Palme, Bruce Ashford, Sydney Ch ng, Marie Ranson, Michael Boyer, Jonathan Clark, Ruta Gupta. Royal Prince Alred Hospital, Sydney, NSW, Australia; Chris O Brien Lifehouse, Sydney, NSW, Australia; University of Sydney, Sydney, NSW, Australia; University of Wollongong, Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia; Illawarra and Shoalhaven Local Health District, Wollongong, NSW, Australia; Centre for Oncology Education and Research Translation, Liverpool, NSW, Australia; University of New South Wales, Sydney, NSW, Australia. 195 Up-Regulation of PLAG1 and HMGA2 mrna in Salivary Gland Neoplasms (1327) Viren Patel, Chao Wu, Xunda Luo, Nirag Jhala, Jasvir S Khurana, Jian Huang, He Wang. Temple University Hospital, Philadelphia, PA; Fox Chase Cancer Center, Philadelphia, PA. 196 Precision HPV Mapping Indicates That Oropharyngeal Squamous Cell Carcinomas Arising in Non-Tonsillar Sites Are Not HPV-Related (1302) Elise Gelwan, Ian-James Malm, Carole Fakhry, Justin A Bishop, William H Westra. The Johns Hopkins Hospital, Baltimore, MD. 197 p16 Expression in Cutaneous Squamous Cell Carcinoma (cscc) of the Head and Neck (1333) Laveniya Satgunaseelan, Hyerim Suh, Sohaib Virk, Bruce Ashford, Trina Lum, Marie Ranson, Jonathan Clark, Ruta Gupta. Royal Prince Alfred Hospital, Sydney, NSW, Australia; University of New South Wales, Sydney, NSW, Australia; University of Wollongong, Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia; Illawarra Shoalhaven Local Health District, Wollongong, NSW, Australia; University of Sydney, Sydney, NSW, Australia; Chris O Brien Lifehouse, Sydney, NSW, Australia. STOWELL-ORBISON AWARD POSTERS: HEMATOPATHOLOGY 198 Validation of Mutant Calreticulin Immunohistochemistry (IHC) in Myeloproliferative Neoplasms (MPN) (1554) Fang Zhao, Mark E Law, David S Viswanatha, Curtis A Hanson, Ayalew Tefferi, Karen L Rech, Rong He. Mayo Clinic, RST, MN. 199 Immunophenotypic Heterogeneity of Polytypic Plasma Cells (1503) Katie Schouweiler, Nitin J Karandikar, Carol Holman. University of Iowa, Iowa City, IA. 200 Novel and Recurrent Chromosomal Copy Alterations in Pediatric B-Cell Non-Hodgkin Lymphomas (1461) Ali Nael, Ashley S Hagiya, Jared T Shows, Dolores Estrine, Gordana Raca, Matthew Oberley. Children s Hospital Los Angeles/Keck School of Medicine, Los Angeles, CA. 201 Juvenile Myelomonocytic Leukemia with CBL Mutation: Report of Three Cases (1453) Rachel Mariani, Lawrence Jennings, Rukhmi Bhat, Shunyou Gong. Lurie Children s Hospital of Chicago, Chicago, IL. 202 Correlation of Morphologic Dysplasia and Gene Mutations in Low-Grade MDS (1350) Anne Marie O Amacher, Matthew Walter, Kiran R Vij, Eric Duncavage. Washington University, Saint Louis, MO. 203 Evaluation of PD1/PDL1 Expression and Their Cliniopathological Association in Age-Related EBV Associated Lymphoproliferative Disorder (1414) Ling Guo, Juraj Bodo, Lisa Durkin, Eric D Hsi. Cleveland Clinic, Cleveland, OH. 126

187 ABSTRACTS POSTER POSTER SESSION SESSION I 204 Light Chain Restricted (LCR) Plasmacytoid Cells in Hyperplastic Germinal Centers (GC): A Clinicopathologic Study (1540) Xuan J Wang, Steven H Swerdlow, Nidhi Aggarwal. University of Pittsburgh Medical Center, Pittsburgh, PA. 205 Flow Cytometric Immunophenotypic Features of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Single Institution Experience (1508) Sasan Setoodeh, Franklin Fuda, Jacob Pilley, Jo Ellen Krueger, Kirthi Kumar, Daniel Gehlbach, Arthur Frankel, Weina Chen. University of Texas Southwestern Medical Center, Dallas, TX. 206 Aberrant Expression of CD19 in Acute Myeloid Leukemia with RUNX1 Mutation: A Diagnostic Clue for the New Entity (1425) Sarika Jain, Shweta Bhavsar, Urvashi Surti, Steven H Swerdlow, Nidhi Aggarwal. University of Pittsburgh School of Medicine, Pittsburgh, PA. 207 TSC1 l Status in Diffuse Large B-cell Lymphomas (1391) Tony El Jabbour, Siddhartha Dalvi, Christine E Sheehan, Tipu Nazeer, Jeffrey Ross. Albany Med Col, Albany, NY. 208 GRP94, a Chaperone Protein, Represents a New Target for Treating Multiple Myeloma (1511) Yulei Shen, Bei Liu, Ping L Zhang. Beaumont Health System, Royal Oak, MI; Medical University of South Carolina, Charleston, SC. 209 A Novel Digital Imaging Based Algorithm to Assess Erythroid Maturation in Bone Marrow Specimens (1541) Milad Webb, Carlos Murga-Zamalloa, Rajan Dewar. University of Michigan, Ann Arbor, MI. 210 SSTR2 Is Frequently Highly Expressed by Diffuse Large B-Cell Lymphoma, Germinal Center Type and Infrequently by Other Hematolymphoid Neoplasms (1438) John P Lee, Dennis P O Malley, Andrew M Bellizzi. University of Iowa, Iowa City, IA; NeoGenomics, Aliso Viejo, CA. 211 Defining Lymphoplasmacytic Lymphoma: Does MYD88 L265P Define a Pathologically Distinct Entity Among Patients with an IgM Paraprotein and Bone Marrow- Based Low Grade B Cell Lymphoma with Plasmacytic Differentiation? (1396) Hong Fang, Prashant Kapoor, Matthew T Howard, Rong He, Ellen D McPhail, Patricia T Greipp, Stephen M Ansell, Jonas Paludo, Jithma Abeykoon, Rebecca King. Mayo Clinic, Rochester, MN. 212 PD-L1 and PD-1 Expression Patterns in Systemic Mastocytosis (1536) Hao-Wei Wang, Sachein Sharma, Jamie Hahn, Hirsh Komarow, Robin Eisch, Dean D Metcalfe, Irina Maric. NIH, Bethesda, MD. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 213 Clinical Indications for PDGFRA/B, or FGFR1 Testing in Hematologic Neoplasms (1469) Lynh Nguyen, Jinming Song, Peter R Papenhausen, Ling Zhang. H. Lee Moffitt Cancer Center, Tampa, FL; Laboratory Corporation of America, Research Triangle Park, NC. 214 Role of the Colony-Stimulator Factor-1 Receptor (CSF1R) T-cell Lymphoma Progression (1460) Carlos Murga-Zamalloa, Avery Polka, Noah Brown, Nathaniel Bailey, Ryan Wilcox. University of Michigan, Ann Arbor, MI. 215 Quantitative Analysis of Ki67 in Mastocytosis Distinguishes Mast Cell Leukemia from Other Subtypes (1516) Payal Sojitra, Ellen W Hatch, Cheyenne Martin, Jason R Gotlib, Heather Ward, Diane S Lidke, Tracy George. University of New Mexico, Albuquerque, NM; Stanford University School of Medicine, Stanford, CA. 216 Increased Marrow Hematogones Following Auto- Transplant Are Uncommon in Adult Patients and Occur Predominantly in the First Year After Transplant (1502) Victor Santiago, Aleksandr Lazaryan, Brian McClune, Elizabeth L Courville. University of Minnesota, Minneapolis, MN. 217 PAX5 Expression Predicts Progression Free Survival in Mantle Cell Lymphoma (1479) Sanjay Patel, Jens Eickhoff, Gene R Shaw, Brad S Kahl, David Yang. University of Wisconsin, Madison, WI; Marshfield Clinic, Marshfield, WI; Washington University School of Medicine, St. Louis, MO. 218 High Expression of Cysteine and Glycine-Rich Protein 2 in Bone Marrow Is Associated with Relapse in Adult B-cell Acute Lymphoblastic Leukemia (1538) Shu-Juan Wang, Ya-Zhen Qin, Yan-Rong Liu, Yue-Yun Lai, Xiao-Jun Huang, Kai-Yan Liu, Guo-Rui Ruan. Peking University People s Hospital and Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China; Peking- Tsinghua Center for Life Sciences, Beijing, China. 219 Prognostic Value of 5-Hydroxymethylcytosine Immunohistochemical Expression in Patients with Multiple Myeloma (1400) Pallavi Kanwar Galera, Karen Dresser, Benjamin Chen. UMass Memorial Medical Center, Worcester, MA. 220 Abnormal Wnt Signaling and p53 Is Associated with Worse Response to Treatment and Overall Survival in Anaplastic Large Cell Lymphoma (ALCL) (1495) Aida Richardson, Wei Cui, Rakesh Mandal, Da Zhang. The University of Kansas Medical Center, Kansas City, KS. 127

188 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall Differential Impact of TKI Therapy on the Natural Course of CML Determines Risk Stratification of Additional Cytogenetic Abnormalities (1408) Zimu Gong, Shi Bai, Zi Chen, Wei Wang, Roberto N Miranda, L Jeffrey Medeiros, Shimin Hu. MD Anderson Cancer Center, Houston, TX. 222 CD30 Expression by RNA Level but Not by PAX5/CD30 Double Stain Is Associated with Worse Outcomes in Diffuse Large B-cell Lymphoma (1520) Luis R Soto, Martha J Glenn, Sheryl Tripp, Noel S Reading, Mohamed Salama, Rodney Miles. University of Utah and ARUP Laboratories, Salt Lake City, UT; Huntsman Cancer Institute, Salt Lake City, UT hmC/CD34 Double Staining in MDS and AML Reveals Selective Loss of 5hmC in Blasts That Correlates with Mutations Affecting Epigenetic Pathways (1498) Ali Sakhdari, Karen Dresser, Benjamin Chen. UMass Memorial Medical Center, Worcester, MA. STOWELL-ORBISON AWARD POSTERS: INFECTIOUS DISEASE PATHOLOGY 224 Unsuspected Spirochetosis in Receipts of Bone Marrow Transplant: An Institutional Review of Case Series (1560) Carolina Dominguez, Alanoud R Fetais, Kun Jiang. Moffitt Cancer Center, Tampa, FL; University of South Florida, Tampa, FL. 225 RNA ISH for Epstein-Barr Virus and Cytomegalovirus: Comparison with In Situ Hybridization and Immunohistochemistry (1575) Catherine J Roe, Momin T Siddiqui, Diane Lawson, Cynthia Cohen. Emory University School of Medicine, Atlanta, GA. 226 Evaluation of the Xpert MTB/RIF Assay for the Detection of Tuberculosis in Patients Being Evaluated for Tuberculosis in a Large Public Hospital in the United States (1564) Andrew Fong, Christina Wei, Alicia H Chang, Peter R Kerndt, Ira A Shulman, Susan Butler-Wu. LAC+USC Medical Center, Los Angeles, CA; Los Angeles County Department of Public Health, Los Angeles, CA. 227 Intestinal Spirochetosis Histologic and Immunohistochemical Patterns: A Case Series (1557) Kathleen Byrnes, Neil Anderson, Bella Goyal. Washington University in St. Louis, St. Louis, MO. 228 Upsurge of Enterovirus D68 Infection in the Lower Hudson Valley, New York, 2016 (1563) Taliya Farooq, Esther C Yoon, Jian Zhuge, Changhong Yin, Weihua Huang, Sheila M Nolan, John T Fallon, Guiqing Wang. New York Medical College at Westchester Medical Center, Valhalla, NY. STOWELL-ORBISON AWARD POSTERS: INFORMATICS 229 Error Reduction of Misidentified Paraffin Blocks Through the Use of Automated Cassette Labeling: A Three Year Follow-Up Study (1604) Christine Rupcich, Alaa Alsadi, Diana Murro, Arlen Brickman, Erika Paulsen, Mark Jaros, Shriram Jakate. Rush University Medical Center, Chicago, IL. 230 Multiple Use Cases for Microsoft HoloLens in Pathology (1587) Matthew G Hanna, Ishtiaque Ahmed, Shyam Prajapati, Jeffrey S Nine, Clayton Wiley, Liron Pantanowitz. UPMC, Pittsburgh, PA; Mount Sinai Hospital, New York, NY. 231 Validation of Fine Needle Aspiration Rapid Onsite Evaluation Using VisionTek Live Digital Microscope (1610) Keluo Yao, Zaibo Li, Anil Parwani, Rulong Shen. The Ohio State University Wexner Medical Center, Columbus, OH. 232 Design and Development of a 3D-Printed Apparatus to Hold a Smartphone for Histologic Examination and Associated Applications (1582) Jesse Cox, Nicholas Lintel, Alexander L Braun, Audrey J Lazenby, Benjamin J Swanson. University of Nebraska Medical Center, Omaha, NE. 233 Computational Image-Analysis to Distinguish Well- Differentiated Hepatocellular Carcinoma from Normal Liver Tissue (1609) Rong Xia, Yongsheng Pan, Amir M Boroujen, M A Haseeb, Raavi Gupta. SUNY Downstate Medical Center, Brooklyn, NY. STOWELL-ORBISON AWARD POSTERS: KIDNEY/RENAL PATHOLOGY (INCLUDING TRANSPLANTATION) 234 De Novo Pauci-Immune Glomerulonephritis in the Renal Allograft (1619) Alessia Buglioni, Mary E Fidler, Sanjeev Sethi, Samih H Nasr, Loren P Herrera Hernandez, Fernando Cosio, Lynn D Cornell. Mayo Clinic, Rochester, MN. 235 Capsulitis Predicts Poor Kidney Allograft Outcome in T-Cell Mediated Rejection (1625) Alexander Gallan, W James Chon, Kammi J Henriksen, Anthony Chang. The University of Chicago, Chicago, IL; University of Arkansas, Little Rock, AR. 236 Thrombotic Microangiopathy in the Kidney, Pathologic Indicators of Disease Severity (1636) Satoru Kudose, Joseph Gaut. Washington University in St. Louis, St. Louis, MO. 128

189 ABSTRACTS POSTER POSTER SESSION SESSION I 237 A Demographic and Pathologic Analysis of 100 Consecutive Renal Core Biopsies in a Tertiary Laboratory in Johannesburg (1640) Washington Mudini, Pulane N Mosiane. University of Witwatersrand, Johannesburg, Gauteng, South Africa; National Health Laboratory Service, Johannesburg, Gauteng, South Africa. STOWELL-ORBISON AWARD POSTERS: LIVER 238 Relapsed and Metastatic Hepatoblastoma: A Comprehensive Genomic Profiling Study (1654) Sanaz Ainechi, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti H Ramkissoon, Siraj M Ali, Alexa Schrock, Sumanta Pal, Hugh A Fisher, Badar Mian, Tipu Nazeer, Hwajeong Lee, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Jeffrey Ross. Albany Med Col, Albany, NY; Foundation Med, Boston, MA; City of Hope, Duarte, CA. 239 The Nearly Normal Liver Biopsy: Presentation, Clinical Associations, and Outcome (1665) Thomas Czeczok, John Van Arnam, Michael S Torbenson, Taofic Mounajjed. Mayo Clinic, Rochester, MN. 240 Hepatocellular Neoplasms Arising in Genetic Metabolic Disorders: Steatosis Is a Common Finding in Both Tumor and Background Liver (1661) Lin Cheng, Dhanpat Jain, Sanjay Kakar, Michael S Torbenson, Tsung-Teh Wu, Matthew M Yeh. University of Washington, Seattle, WA; Yale University, New Haven, CT; University of California, San Francisco, CA; Mayo Clinic, Rochester, MN. 241 PD-L1 and LAG3 Expression in Hepatocellular Carcinoma Associated with HCV and Steatohepatitis (1707) Dongmei Xing, Lan Luan, Qingfeng Zhu, Faiz Gani, Timothy Pawlik, Janis M Taube, Robert A Anders. Weill Cornell Medicine, New York, NY; Johns Hopkins University, Baltimore, MD. 242 Histologic Assessment of HCV Liver Transplant Recipients with Sustained Virologic Response After Treatment with Direct-Acting Antiviral Agents (1690) Juan Putra, Thomas D Schiano, M Isabel Fiel. Icahn School of Medicine at Mount Sinai, New York, NY. 243 Hexokinase Domain-Containing Protein 1 (HKDC1) Is Overexpressed and Correlated with the Histological Progression of Nonalcoholic Fatty Liver Disease (1704) Neelima Valluru, Hui Zhang, Hannah H Chen, Jasmin Sandhu, Brian Layden, Scott Cotler, Stefan Pambuccian, Xianzhong Ding. Loyola University Medical Center, Maywood, IL; Northwestern University, Chicago, IL. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 244 Utility of Copper Staining in Determining the Etiology of Cirrhosis (1687) Daniel J Pelletier, Thomas Czeczok, Andrew M Bellizzi, Sarag Boukhar. University of Iowa Hospitals and Clinics, Iowa City, IA; Mayo Clinic, Rochester, MN. 245 Is Albumin RNA In Situ Hybridization (RISH) a Reliable Marker for Intrahepatic Cholangiocarcinomas? (1657) Vaidehi Avadhani, Momin T Siddiqui, Diane Lawson, Cynthia Cohen, Alyssa Krasinskas. Emory University, Atlanta, GA. STOWELL-ORBISON AWARD POSTERS: NEUROPATHOLOGY AND OPHTHALMIC PATHOLOGY 246 Utility of Somatostatin Receptor 2a Immunohistochemistry in the Clear Cell Tumor Differential of the Central Nervous System (1737) Abigail L Goodman, Jose E Velazquez Vega, Stewart Neill, Matthew Schniederjan, Stephen Hunter, Cynthia Cohen, Daniel J Brat. Emory University Hospital, Atlanta, GA. 247 Molecular and Histologic Features of a Series of Sporadic and Familial Schwannomas (1763) Erik Williams, James Kim, Alona Muzikansky, McKenzie Shaw, John Iafrate, Scott Plotkin, Mario Suva, Anat Stemmer-Rachamimov. Massachusetts General Hospital, Boston, MA; Broad Institute of MIT and Harvard, Boston, MA. 248 SSTR2 Is Highly Expressed by Meningiomas: A Novel Diagnostic and Potential Therapeutic Target (1764) Angela Wu, Andrew M Bellizzi. University of Iowa, Iowa City, IA. 249 Loss of Expression of SWI/SNF Chromatin Remodeling Complex Proteins in Sporadic Pituitary Adenomas (1741) Upasana Joneja, Markku M Miettinen, Varun Kshettry, James J Evans, Mark T Curtis. Thomas Jefferson University Hospital, Philadelphia, PA; National Cancer Institute, Bethesda, MD. 250 CSF Cytokine Profiles Discriminate CNS B-Cell Lymphoma from Other Neuropathologic Processes (1733) Danielle Fortuna, Amity L Roberts, Larry A Harshyne, D Craig Hooper, Mark T Curtis. Thomas Jefferson University Hospital, Philadelphia, PA. 251 Targeted Mutation Profiling by the Extended Next GenerationSequencing Assay and Clinical Utility of Actionable Genomic Alterations in CNS Tumors: A Single Academic Institution Experience (1742) Jong Kim, Kimberly J Newsom, Ashley P Ghiaseddin, Jesse L Kresak, Petr Starostik. University of Florida Health, Gainesville, FL. 129

190 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall Histological Spectrum of Oligodendroglial Tumours: IDH1/2, ATRX and 1p19q (1762) Amol Wadile, Hetakshi Khurani, Mamta Gurav, Omshree Shetty, Tejpal Gupta, Aliasgar Moiyadi, Prakash Shetty, JayantSastri Goda, Rakesh Jalali, Sridhar Epari. Tata Memorial Centre, Mumbai, Maharashtra, India. 253 Prognostic Significance and Characterization of a Small Cell Population in Uveal Melanoma (1767) Pablo Zoroquiain, Evangelina Esposito, Ciro Garcia, Maria A Saornil, William April, Miguel N Burnier. McGill University, Montreal, QC, Canada; Pontificia Universidad Catolica de Chile, Santiago, Chile. 254 Expresion of HER2 in Ocular Surface Squamous Neoplasia (1731) Evangelina Esposito, Pablo Zoroquiain, Ana B Toledo Dias, Miguel N Burnier. McGill University, Montreal, QC, Canada. STOWELL-ORBISON AWARD POSTERS: PANCREAS AND BILIARY TREE 255 Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases (1773) Gokce Askan, Volkan Adsay, Deepti Dhall, Giuseppe Zamboni, Michio Shimizu, Karina Cymes, Fatima Carneiro, Serdar Balci, Carlie Sigel, Michelle D Reid, Irene Esposito, Helena Baldaia, Peter Allen, Günter Klöppel, David S Klimstra, Olca Basturk. MSKCC, NYC, NY; Emory U, Atlanta, GA; U of Verona, Verona, Italy; Hakujikai Memorial Hospital, Tokyo, Japan; U of Porto, Porto, Portugal; Heinriche-Heine University of Dusseldorf, Düsseldorf, Germany; Technical U, Munich, Germany. 256 Alternative Lengthening of Telomeres and Loss of ATRX/DAXX Can Be Reliably Detected in Fine Needle Aspirates of Pancreatic Neuroendocrine Tumors (1772) Derek Allison, Christopher M Heaphy, Mindy K Graham, Vivek Charu, Ralph H Hruban, Christopher VandenBussche. The Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins Medical Institutions, Baltimore, MD. 257 p16 Immunohistochemistry Reveals Clinicopathologically Distinct Subsets of Pancreatic Cancer (1781) Craig Dunseth, Jon Thomason, Megan Samuelson, James J Mezhir, Sarah L Mott, Andrew M Bellizzi. University of Iowa, Iowa City, IA. 258 Investigation of the Genomic Landscape of Gall Bladder Carcinoma for Predictive and Prognostic Markers (1802) Azfar Neyaz, Nuzhat Husain, Swati Kumari, Sameer Gupta, Sanjeev Misra. Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India; King George s Medical University, Lucknow, India. 259 Characterization and Diagnosis of Small Pancreatic Serous Cystadenomas (1801) Pooja Navale, Abul Ala Syed Rifat Mannan, Devi Jeyachandran, Xiaofei Zhang, Francesco Priamo, Huai-Bin Mabel Ko, Alexander Kagen, Alexandros D Polydorides, Noam Harpaz, Hongfa Zhu. Icahn School of Medicine at Mount Sinai, New York, NY. 260 MUC13 Mucoprotein Is a Reliable Diagnostic and Prognostic Marker for Pancreatic Ductal Adenocarcinoma (1775) Wafi Bibars, Sheema Khan, Meena Jaggi, Subhash Chauhan, Nadeem Zafar. University of Tennessee Health Sciences Center, Memphis, TN. 261 Molecular Characteristics of Intraductal Oncocytic Papillary Neoplasms of the Bile Ducts (1807) Deepthi Rao, Gokce Askan, Volkan Adsay, Rhonda K Yantiss, Maura O Neil, David S Klimstra, Olca Basturk. Memorial Sloan Kettering Cancer Center, New York, NY; Emory University, Atlanta, GA; Weill Cornell Medical College, New York, NY; University of Kansas Medical Center, Kansas City, KS. 262 Can Pathologic Subclassification of Ampullary Carcinoma Identify Clinically Meaningful Groups? (1797) Nisha Modi, Munita Bal, Swapnil Rane, Mukta Ramadwar, Kedar Deodhar, Shailesh Shrikhande. Tata Memorial Centre, Mumbai, Maharashtra, India. 263 Immunohistochemical Detection of Loss Expression of ATRX/DAXX in Neuroendocrine Tumors from Various Organs (1806) Yelena Piazza, Haiyan Liu, Fan Lin. Geisinger Medical Center, Danville, PA. STOWELL-ORBISON AWARD POSTERS: PATHOBIOLOGY (INCLUDING PAN-GENOMIC/PAN-PROTEOMIC APPROACHES TO CANCER) 264 CCR10-Expressing IgG+ Plasma Cells Compensate for IgA Deficiency in Colon of Patients with Selective IgA Deficiency (1839) Shaomin Hu, Yanhua Wang, Joseph Albanese, Yungtai Lo, Qiang Liu. Montefiore Medical Center/AECOM, Bronx, NY. 130

191 ABSTRACTS POSTER POSTER SESSION SESSION I 265 Co-Mutations of Driver Oncogenes in Untreated Primary Lung Adenocarcinomas (ADCs) and Clinical Correlations (1850) Doreen Nguyen, Minghui Ao, Frederic Askin, Ed Gabrielson, Gang Zheng, Qing K Li. The Johns Hopkins Medical Institutions, Baltimore, MD. STOWELL-ORBISON AWARD POSTERS: PEDIATRIC PATHOLOGY 266 Quantification of Colonic Mucosal Calretinin Immunostain in Hirschsprung s Disease (HD) Pull- Through Specimen by Image Processing and Analysis (IPA) Shows Substantial Variation and Limits Its Utility in Preoperative Mapping of Transition Zone (1881) Israel Kasago, Sangtae Ahn, Sanaz Ainechi, Chunlai Zuo, Suzanne Homan, Christine E Sheehan, Hwajeong Lee. Albany Medical College, Albany, NY. 267 Genome-Wide DNA Methylation Profiling in the Diagnosis of Pediatric Ewing Sarcoma, Osteosarcoma, and Synovial Sarcoma (1867) Fang Bu, Benjamin Cooper, Peter Wu, Marc Ladanyi, Richard G Gorlick, Matthias Karajannis, Kristen M Thomas, Matija Snuderl. New York University Medical Center, New York, NY; Memorial Sloan Kettering Cancer Center, New York, NY; The Children s Hospital at Montefiore, New York, NY. 268 Norovirus Infection in Pediatric Small Intestine Allografts: A Clinicopathological Study of a Cohort of 23 Patients (1895) Wei Xu, Stuart Kaufman, Joeffrey Chahine, Brandi Higgins, Nada Yazigi, Cal Matsumoto, Khalid Khan, Bhaskar VS Kallakury. Medstar Georgetown Univeristy Hospital, Washington, DC. STOWELL-ORBISON AWARD POSTERS: PULMONARY PATHOLOGY (INCLUDING MEDIASTINAL) 269 The Development of Brain Metastasis in Lung Adenocarcinoma Is Associated with a High Rate of Tumor Necrosis in the Primary Tumor and the Selection of Cribriform and Solid Growth Patterns (1897) Khaleel I Al-Obaidy, Fulvio Lonardo. Wayne State Univeristy/ Detroit Medical Center/ Karmanos Cancer Institute, Detroit, MI. 270 Correlation of PD-L1 Expression with Molecular Driver Oncogene Mutations in Non-Small Cell Lung Cancer (1988) Jason V Scapa, Haodong Xu. David Geffen School of Medicine at UCLA, Los Angeles, CA. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 271 A Semi-Quantitative Approach to Biopsy Diagnosis of Large Cell Neuroendocrine Carcinoma of the Lung (1900) Marina K Baine, Robert J Homer. Yale University, Yale New Haven Hospital, New Haven, CT. 272 Comprehensive Analysis of PD-L1 Expression in Primary Resected Squamous Cell Carcinoma of the Lung and Lymph Node Metastases (1959) Christina Neppl, Manuel Keller, Yasin Irmak, Sean R Hall, Ralph A Schmid, Rupert Langer, Sabina Berezowska. University of Bern, Bern, Switzerland; Inselspital University Hospital Bern, Bern, Switzerland. 273 Molecular Injury and Repair Assessment in Ex Vivo Perfused Swine Lung Transplants (1914) Peter Dromparis, Siegfried Wagner, Nader Aboelnazar, Sayed Himmat, Jessica GY Luc, Darren Freed, Jayan Nagendran, Michael Mengel, Benjamin Adam. University of Alberta, Edmonton, AB, Canada. 274 Inflammatory Pseudotumor Arising from Pulmonary Thrombi: Analysis of a Case Series (1947) Xiaoyan Liao, Christine M Bojanowski, Eunhee S Yi, Huan-You Wang, Kim M Kerr, Justin Dumouchel, Grace Y Lin. UCSD, San Diego, CA; Mayo Clinic, Rochester, MN. 275 Temporal and Spatial Heterogeneity of Programmed Cell Death-Ligand 1 Expression in Malignant Mesothelioma (1998) Simone BSP Terra, Aaron S Mansfield, Tobias Peikert, Anja C Roden. Mayo Clinic, Rochester, MN. 276 Pulmonary Squamous Cell Carcinoma with Lepidic Pattern- A Study of 9 Cases (1994) Hemlata Shirsat, Ashley E Stueck, Mathieu C Castonguay, Zhaolin Xu. Dalhousie University, Halifax, NS, Canada. 277 Comprehensive Assessment of PD-L1 Staining Heterogeneity and Expression by Histologic Pattern in Pulmonary Adenocarcinomas: Clinical Implications (1925) Andréanne Gagné, William Enlow, Marc-Antoine Pigeon, Michèle Orain, Stéphane Turcotte, Philippe Joubert. Laval University, Quebec City, QC, Canada; Quebec Lung and Heart University Institute, Quebec City, QC, Canada; CHU de Québec, Quebec City, QC, Canada. 278 PHH3 Immunostaining Reduces the Evaluation Time and Facilitates Histologic Assessment of Pulmonary Carcinoid Tumors (1940) Babak Khoshkrood-Mansoori, Olga Sazonova, Michèle Orain, Sylvain Trahan, Serge Simard, Philippe Joubert. Université Laval, Quebec, QC, Canada; Quebec Heart and Lung Institute, Quebec, QC, Canada. 131

192 ABSTRACTS POSTER SESSION POSTER SESSION I Monday, March Day, 06, Date, :30 0:00 AM AM - 12:00-0:00 PM PM Exhibit Hall Differential Expression of Immune Inhibitory Markers in Association with the Immune Microenvironment in Resected Lung Adenocarcinomas (2012) Mingjuan L Zhang, Marina Kem, Meghan J Campo, Tiffany Huynh, Justin F Gainor, Mari Mino-Kenudson. Massachusetts General Hospital, Boston, MA. 280 Identification of Criteria Predicting the Pertinence of Frozen Section Evaluation of Margins in Lung Cancer Resections (1975) Étienne Racine, Michèle Orain, Sylvain Trahan, Yves Lacasse, Paula Ugalde, Serge Simard, Philippe Joubert. Laval University, Quebec City, QC, Canada; Quebec Heart and Lung Institute, Quebec City, QC, Canada. 281 Comparative Analysis of Lung Lesions of Systemic IgG4-Related Disease and Idiopathic Multicentric Castleman s Disease (1943) Nariaki Kokuho, Yasuhiro Terasaki, Mika Terasaki, Shinobu Kunugi, Akira Hebisawa, Yoshinori Kawabata, Yuh Fukuda, Akira Shimizu. Nippon Medical School, Tokyo, Japan; NHO Tokyo National Hospital, Tokyo, Japan; Saitama Prefectural Cardiovascular, Respiratory Center, Saitama, Japan. 282 Primary Pulmonary Artery Sarcoma: A Single-Center Retrospective Case Series of 41 Patients (1915) Zeljko Dvanajscak, Jennifer Katzenberg, Kim M Kerr, Eunhee S Yi, Grace Y Lin. UCSD, San Diego, CA; Mayo, Rochester, MN. STOWELL-ORBISON AWARD POSTERS: QUALITY ASSURANCE 283 Six Sigma A Metric for Quality Improvement in Anatomic Pathology (2063) Rebecca May, Ketan Patel, Lynita Thomas, Charuhas Deshpande. Hospital of the University of Pennsylvania, Philadelphia, PA. 284 Impact of Feedback and an Educational Intervention on Academic Pathologists Rates of Helicobacter Pylori (HP) Immunostain Use and HP Detection Rates (2048) Bogdan Isaila, Razvan Lapadat, Yi Zhou, Xianzhong Ding, Stefan Pambuccian. Loyola University Medical Center, Maywood, IL; Medical College of Wisconsin, Milwaukee, WI. 285 Addressing Clinician s Concern for Lack of Transformation Zone in Cervical PAP Tests: A Quality Assurance Initiative (2077) Evelyn C Polanco Jacome, Karen Chau, Sujata Sajjan, Saeed Asiry, Melissa Klein, Fanya Epelbaum, Cecilia E Gimenez, Alice Laser, Rubina S Cocker, Kasturi Das. Hofstra Northwell School of Medicine, Lake Success, NY; Northwell Health, Lake Success, NY. 286 Implementation of a Quality Assurance (QA) Initiative for Improving Pathology Diagnosis and Molecular Subtype Characterization of Breast Cancer in Zambia (2025) Allen C Chama, Aaron L Shibemba, Kabisa Mwala, Catherine Mwaba, Susan C Msadabwe-Chikune, Isaac Mweemba, Dalliah M Black, Mark A Bailey, Mary E Edgerton. University Teaching Hospital, Lusaka, Zambia; Cancer Diseases Hospital, Lusaka, Zambia; UT MD Anderson Cancer Center, Houston, TX. 287 Genomic Testing Using Cytology vs Surgical Specimens: A Comparative Study (2092) Rebecca M Steele, Umit Topaloglu, Lance D Miller, Wei Zhang, Boris Pasche, Barry R DeYoung, Shadi A Qasem. Wake Forest School of Medicine, Winston-Salem, NC Months of Block Quality Feedback to Residents: Are We Getting Better? (2075) Garrison Pease, Talent Theparee, William Watkin. Evanston Hospital, Evanston, IL. 289 p16 Immunohistochemistry Is Not Required for Accurate Diagnosis of Cervical Intraepithelial Neoplasia, Grade 2 (CIN 2), When Histologic Features Suggest a Definite High-Grade Squamous Intraepithelial Lesion (2093) Lulu Sun, Lingxin Zhang, Hannah Krigman, Ian Hagemann. Washington University in St. Louis, St. Louis, MO. 290 Three FDA Approved PD-L1 Assays Demonstrate Concordant PD-L1 Expression in Various Solid and Hematologic Tumors, with Higher Expression in Hodgkin and Diffuse Large B-Cell Lymphomas (2099) Peng Wang, Joeffrey Chahine, Brandi Higgins, Jose deguzman, Bhaskar VS Kallakury. Medstar Georgetown University Hospital, Washington, DC. 291 Establishing and Improving Diagnostic Precision in an Academic Non-Subspecialized Practice (2024) Anas Bernieh, Kim R Geisinger, Dana M Grzybicki, Ali G Saad, Dianne E Grunes, Siraj M El Jamal, Israh Akhtar, Varsha Manucha, Stephen Raab. University of Mississippi Medical Center, Jackson, MS. STOWELL-ORBISON AWARD POSTERS: TECHNIQUES (INCLUDING ULTRASTRUCTURE) 292 Molecular Lymph Node Analysis in Colorectal Carcinoma. Is HE Obsolete in the Molecular Era? (2139) Carla Montironi, Iban Aldecoa, Natalia Rakislova, Josep Antoni Bombi, Nuria Chic, Joan Maurel, Francesc Balaguer, Maria Pellise, Antoni Castells, Miriam Cuatrecasas. Hospital Clinic, Barcelona, Spain. 132

193 ABSTRACTS POSTER POSTER SESSION SESSION I 293 Diagnostic Utility of Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Preeclamptic Placenta Tissue (2104) Oluwatobi Adelaja, Vishal K Varma, Virgilia Macias, Andre Balla, Michael Walsh. University of Illinois Hospital and Health Sciences Systems, Chicago, IL; University of Illinois at Chicago, Chicago, IL. 294 An Exploratory Study Employing Hepatocyte Nuclear FOXM1 Immunoexpression by Vectra Automated Multispectral Imaging System: Inching Towards Quantitative Pathology as a Diagnostic Tool (2148) Christine J Salibay, Yi-Fan Chen, Ryan Deaton, Luis Manon, Janais Peace, Michael Walsh, Pradip Raychaudhuri, Frederick Behm, Grace Guzman. University of Illinois Hospital & Health Sciences System, Chicago, IL; Center for Clinical and Translational Science, Chicago, IL. 295 Quantification of Colonic Mucosal Calretinin Immunostain in Hirschsprung s Disease (HD) by Image Processing and Analysis (IPA) Correlates with Pathologist Visual Interpretation (2162) Chunlai Zuo, Sangtae Ahn, Israel Kasago, Sanaz Ainechi, Suzanne Homan, Christine E Sheehan, Hwajeong Lee. Albany Medical College, Albany, NY. Monday, Day, March Date, , :00 9:30 AM - AM 0:00-12:00 PM PM 296 Massively Parallel Sequencing Approach for the Detection of XP11 Translocation in Renal Cell Carcinoma (2146) Omid Rouhi, Tong Yang, Jordan Magee Owens, Heather H Jones, Wanhong Jiang, Momin T Siddiqui, Charles E Hill, Cynthia Cohen. Emory University, Atlanta, GA. 297 Nicotinamide Phosphoribosyltransferase a Novel Marker for Cervical Dysplasia (2105) Lubna A Alattia, Moiz Vora, Junaid Ansari, Menchu Ong, James Cotelingam, Domenico Coppola, Rodney Shackelford. LSU Health Shreveport, Shreveport, LA; Feist-Weiller Cancer Center, Shreveport, LA; Moffitt Medical Group, Tampa, FL. 298 Deep Learning Classifier to Predict Cardiac Failure from Whole-Slide H&E Images (2141) Jeffrey Nirschl, Andrew Janowczyk, Eliot Peyster, Renee Frank, Kenneth Margulies, Michael Feldman, Anant Madabhushi. University of Pennsylvania, Philadelphia, PA; Case Western Reserve University, Cleveland, OH. PROFFERED PAPERS Monday, March 06, :00 PM 3:00 PM CC SNB 3&4 SECTION A GENITOURINARY CHAIRED BY: JOHN C CHEVILLE AND MARIA TRETIAKOVA 1:00 Identifying Oncogenic Pathways in Renal Cell Carcinoma with Unclassified Histology (urcc): A Validation Study of 59 Patients (874) Ying-Bei Chen, Mazyar Ghanaat, Ari Hakimi, Hikmat Al-Ahmadie, Samson W Fine, Anuradha Gopalan, Sahussapont J Sirintrapun, Gowtham Jayakumaran, Maria E Arcila, Chung-Han Lee, Martin H Voss, Darren Feldman, Robert J Motzer, James J Hsieh, Satish K Tickoo, Victor E Reuter. Memorial Sloan Kettering Cancer Center, New York, NY. 1:15 Molecular Characterization of Tubulocystic Carcinoma of the Kidney (1038) Judy Sarungbam, Rohit Mehra, Scott A Tomlins, Steven C Smith, Hikmat Al-Ahmadie, Anuradha Gopalan, Sahussapont J Sirintrapun, Samson W Fine, Mahul B Amin, Victor E Reuter, Yingbei Chen, Satish K Tickoo. MSKCC, NY, NY; UMICH, Ann Arbor, MI; UTHSC, Memphis, TN; MMC, Bronx, NY; VCU, Richmond, VA. 1:30 The Unrecognized Morphologies of HLRCC Renal Cancer That Pathologists Need to Know. Molecular and IHC Findings (989) Vanessa Moreno, Xu Naizhen, Ramaprasad Srinivasan, W Marston Linehan, Maria J Merino. National Cancer Institute, Bethesda, MD. 1:45 Acquired Cystic Disease-Associated Renal Cell Carcinoma: A Single Institutional Morphologic and Immunohistochemical Study (1033) Joseph Sanfrancesco, Hiroyuki Hayashi, Muhammad Idrees, Liang Cheng, John N Eble, David Grignon. Indiana University, Indianapolis, IN; Fukuoka University, Fukuoka, Japan. 2:00 Monosomy 8 as a Surrogate for TCEB1 Mutation in Renal Cell Tumors with Prominent Stroma (1078) Sean R Williamson, Nallasivam Palanisamy. Henry Ford Health System, Detroit, MI. 2:15 Characterization of Driver Mutations in Hybrid Renal Oncocytic Tumors (1022) Roberto Ruiz-Cordero, Priya Rao, Pheroze Tamboli, Rajesh Singh, Mark J Routbort, Kanishka Sircar. MD Anderson Cancer Center, Houston, TX. 133

194 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 1:00 PM - Exhibit 3:00 PM Hall 1 2:30 Low-Grade Spindle Cell Proliferation in Clear Cell Renal Cell Carcinoma Is Unlikely an Initial Step in Sarcomatoid Differentiation (1054) Ozlem Tanas Isikci, Huiying He, Petr Grossmann, Reza Alaghehbandan, Monika Ulamec, Fredrik Petersson, Delia Perez Montiel, Kvetoslava Michalova, Kristyna Pivovarcikova, Ondrej Ondic, Bohuslava Saskova, Pavla Rotterova, Milan Hora, Michal Michal, Ondrej Hes. Ankara Education and Research Hospital, Ankara, Turkey; Peking University, Science Center, Beijing, China; Charles University, Medical Faculty and University Hospital, Plzen, Czech Republic; Faculty of Medicine, University of British Columbia, Vancouver, Canada; Clinical Hospital Center, Medical Faculty, Zagreb, Croatia; National University Health system, Singapore, Singapore; Institute Nacional de Cancerologia, Mexico City, Mexico. 2:45 Pathologic Features of Renal Carcinoma Following Anti-PD1 Therapy. A Clinicopathologic Analysis of 12 Cases (1026) Rashmi Samdani, Priya Rao. The University of Texas MD Anderson Cancer Center, Houston, TX. 3:00 BREAK CC HEMISFAIR 1 SECTION B PULMONARY CHAIRED BY: ANNIKKA WEISSFERDT AND ROBERT J HOMER 1:00 Nuclear Grade, Necrosis and Solid Growth Pattern Predict Survival in Epithelioid Malignant Mesothelioma: An International, Multi-Institutional Study (1980) Lauren E Rosen, Vijayalakshmi Ananthanarayanan, Alexander Gallan, Melissa Yuwono Tjota, Richard Attanoos, Fouad S Alchami, Luka Brcic, Kelly Butnor, Kenzo Hiroshima, Astero Klampatsa, Leslie Litzky, Alberto M Marchevsky, Filomena Medeiros, M Angeles Montero-Fernandez, David A Moore, Kazuki Nabeshima, Elizabeth N Pavlisko, Anupama Sharma, Michael Sheaff, Ann E Walts, Francoise Galateau, Nolwenn Le Stang, Thomas Krausz, Aliya N Husain. University of Chicago, Chicago, IL; Loyola, Maywood, IL; University of Wales, Cardiff, United Kingdom; Medical University of Graz, Graz, Austria; University of Vermont, Burlington, VT; Tokyo Women s Medical Center, Kawadacho, Japan; University of Pennsylvania, Philadelphia, PA; Cedars-Sinai Medical Center, Los Angeles, CA; Basildon & Thurrock University Hospital, Basildon, United Kingdom; Royal Brompton and Harefield Hospitals, London, United Kingdom; University of Leicester, Leicester, United Kingdom; Fukuoka University, Fukuoka, Japan; Duke University, Durham, NH; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA; Barts Health NHS Trust, London, United Kingdom; Centre Leon Berard, Lyon, France. 1:15 A Subset of Diffuse Malignant Peritoneal Mesothelioma Have Novel ALK Rearrangements and Distinct Clinicopathologic Features (1931) Yin (Rex) Hung, Fei Dong, Valentina Nardi, Jaclyn C Watkins, John Godleski, Paola Dal Cin, Christopher P Crum, Lucian R Chirieac. Brigham and Women s Hospital, Boston, MA; Massachusetts General Hospital, Boston, MA. 1:30 Histopathologic Findings in Lung Biopsies from Patients with Primary Biliary Cirrhosis (PBC) (1946) Hee Eun Lee, Jay H Ryu, Ana-Maria Bilawich, Andrew Churg, Henry D Tazelaar, Eunhee S Yi. Mayo Clinic, Rochester, MN; University of British Columbia, Vancouver, Canada; Mayo Clinic, Scottsdale, AZ. 1:45 Lung Transplant Outcomes in Emphysema Patients with Granulomas (1984) Rex Michael Santiago, Tahani Al-Baqer, Zanobia Khan, Sassan Azad, Yizhuo Gao, Shaf Keshavjee, Ming- Sound Tsao, David Hwang. University Health Network, Toronto, ON, Canada. 2:00 Similar Molecular Subtypes of Lung Injury Patterns in Interstital Lung Disease, Stem Cell and Lung Transplantation (1945) Florian Laenger, Jens Gottlieb, Matthias Eder, Gregor Warnecke, Mark Kuehnel, Hans H Kreipe, Danny Jonigk. Medical School Hanover, Hanover, Germany. 2: WHO Thymoma Classification: Prognostic Value of Heterogeneity in Thymomas (1938) Mohamed K Kamel, Navneet Narula, Brendon M Stiles, Jeffrey L Port, Nasser K Altorki. New York Presbyterian Hospital Weill Cornell Medicine, New York, NY. 2:30 PD-L1 Expression in Thymomas and Thymic Carcinomas: Correlation with Clinicopathologic Features (1962) Patricia P Odashiro, Michèle Orain, Daniela Furrer, Caroline Diorio, David Simonyan, André Moreira, Philippe Joubert. Quebec Heart and Lung Institute L IUCPQ, Québec, QC, Canada; Centre de recherche du CHU de Québec Université Laval, Québec, QC, Canada; New York University, New York, NY. 2:45 Targeted Next Generation Sequencing Identifies Distinct Mutational Profiles of Thymomas and Thymic Carcinomas (1934) Tyler Janovitz, Lynette M Sholl, Fei Dong. Brigham and Women s Hospital, Boston, MA. 3:00 BREAK 134

195 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 1:00 PM - Exhibit 3:00 PM Hall 1 CC 225 SECTION C HEMATOPATHOLOGY CHAIRED BY: DAPHNE DE JONG AND SARAH ONDREJKA 1:00 Gene Expression Profiling Reveals Distinct Molecular Subsets in NK/T-Cell Lymphoma (1468) Siok-Bian Ng, Seiichi Kato, Emiko Takahashi, Shigeo Nakamura, Young Hyeh Ko, Shih-Sung Chuang, Joseph Khoury, Wee-Joo Chng. National University of Singapore, Singapore, Singapore; Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea; Nagoya University Hospital, Nagoya, Aichi-ken, Japan; Chi-Mei Medical Center, Tainan, Taipei, Taiwan; MD Anderson Cancer Center, Houston, TX; Aichi Medical University Hospital, Nagakute, Aichi, Japan. 1:15 A Retrospective Study of 305 Cases of Angioimmunoblastic T-Cell Lymphoma with Emphasis on Rare Lymphoplasmacytic and Plasma Cell Proliferations (1472) Jean Oak, Jenny C Hoffmann, Karen M Chisholm, Jennifer Chen, James Zehnder, Daniel A Arber, Yasodha Natkunam, Roger Warnke, Robert Ohgami. Stanford University, Stanford, CA; Seattle Children s Hospital, Seattle, WA; Yale Medical School, New Haven, CT. 1:30 Pathological Features of Angioimmunoblastic T-Cell Lymphomas with IDH2 R172 Mutations (1507) Ebru Serinsoz Linke, Moritz Mederake, Julia Steinhilber, Irina Bonzheim, Falko Fend, Leticia Quintanilla-Martinez. University Hospital Tübingen, Tübingen, Germany. 1:45 Adult T-cell Leukemia/Lymphoma (ATLL): A Mimicker of Other More Common T-Cell Neoplasms (1431) Mahsa Khanlari, Sandra Sanchez, Germán Campuzano- Zuluaga, Juan Carlos Ramos, Jeong Hee Cho-Vega, Francisco Vega, Jennifer Chapman. University of Miami, Miami, FL. 2:00 Molecular Characteristics and Their Clinical Correlation in T-cell Large Granular Lymphocytic Leukemia (T-LGL) (1512) Min Shi, Rong He, Andrew Feldman, David S Viswanatha, William G Morice. Mayo Clinic, Rochester, MN. 2:15 Naïve and Memory T-cell Immunophenotypes in Mycosis Fungoides and Sezary Syndrome. Cell-of- Origin Subtypes Overlap Disease Classification (1421) Pedro Horna, L F Glass, Lubomir Sokol. Moffitt Cancer Center, Tampa, FL; Mayo Clinic, Rochester, MN; George Washington University, Washington, DC. 2:30 A Long-Term Study of Persistent Sézary Syndrome: Evidence for Antigenic Shift by Multiparameter Flow Cytometry and Its Significance in Overall Survival (1419) Jenny C Hoffmann, Robert Ohgami. Stanford University Medical Center, Stanford, CA. 2:45 The Immunophenotypic Appearance of Plasmacytoid Dendritic Cells in Various Specimens (1484) Jacob Pilley, Weina Chen, Sasan Setoodeh, Kirthi Kumar, Franklin Fuda. Univeristy of Texas Southwestern, Dallas, TX. 3:00 BREAK CC HEMISFAIR 3 SECTION D BREAST CHAIRED BY: GREGOR KRINGS AND KALLIOPI P SIZIOPIKOU 1:00 Evaluation of Sentinel Lymph Nodes (SLN) in Classic Invasive Lobular Carcinoma (cilc): Study of 560 Cases Indicates Need for CK Staining and Inapplicability of Size Criterion (i.e. </>0.2 mm) to Distinguish pn0i+ from pnmi for Precise Staging (246) Ami Patel, Timothy D Alfonso, Esther Cheng, Syed A Hoda. New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY. 1:15 Prognostic Impact of the Size of Extracapsular Extension of Axillary Lymph Node Metastases in Breast Cancer: Association with Clinicopathological Features and Outcome (138) Francisca IBCC da Matta, Carlos H de Figueiredo, Rafael F Oliveira, Paulo H Azevedo, Marina De Brot. Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. 1:30 Anatomy and Terminology of Breast Oncoplastic Large Volume Displacement Surgery Specimens (214) Yuanxin Liang, Abhishek Chatterjee, Stephen Naber. Tufts Medical Center, Boston, MA. 1:45 Pure Intralymphatic Carcinoma Following Neoadjuvant Chemotherapy for Breast Carcinoma Is Associated with Poor Prognosis and Should Not Be Considered Pathologic Complete Response (126) Esther Cheng, Michaela Nguyen, Tracy-Ann Moo, Eleni Andreopoulou, Syed A Hoda, Timothy D Alfonso. Weill Cornell Medicine, New York, NY. 2:00 Breast Cancer in Li-Fraumeni Syndrome: Morphologic Evaluation of Invasive and In Situ Carcinomas (202) Maria G Kuba, Susan C Lester, Teresa Bowman, Judy Garber, Deborah A Dillon. Brigham and Women s Hospital, Boston, MA; Dana- Farber Cancer Institute, Boston, MA. 2:15 Genomic Profiling of Secretory Carcinoma (199) Gregor Krings, Nancy M Joseph, Gregory Bean, Courtney Onodera, Eric Talevich, Iwei Yeh, Richard Jordan, James Grenert, Elizabeth Hosfield, Charles Zaloudek, Annemieke Van Zante, Sandra J Shin, Yunn- Yi Chen. UCSF, San Francisco, CA; Kaiser, Oakland, CA; Cornell, NY, NY. 135

196 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 1:00 PM - Exhibit 3:00 PM Hall 1 2:30 The Genomic Landscape of PALB2-Associated Breast Cancers (207) Anqi Li, Britta Weigelt, Kathleen A Burke, Pier Selenica, Hannah Y Wen, Salvatore Piscuoglio, Felipe Geyer, Fresia Pareja, Melissa Southey, Arto Mannermaa, Marketa Janatova, Soo-Twang Teo, Marc Tischkowitz, William Foulkes, Jorge Reis-Filho. Memorial Sloan Kettering Cancer Center, New York, NY; The University of Melbourne, Parkville, Australia; Cancer Center of Eastern Finland, Kuopio, Finland; Charles University, Prague, Czech Republic; Cancer Research Malaysia, Subang Jaya, Malaysia; Cambridge University, Cambridge, United Kingdom; McGill University, Montreal, Canada. 2:45 Genomic Landscape of Phyllodes Tumors with and without Fibroadenoma-Like Areas (243) Fresia Pareja, Felipe C Geyer, Kathleen A Burke, Salvatore Piscuoglio, Marcia Edelweiss, Melissa Murray, Edi Brogi, Britta Weigelt, Jorge S Reis-Filho. Memorial Sloan Kettering Cancer Center, New York, NY; Institute of Pathology, University Hospital Basel, Basel, Switzerland. 3:00 BREAK CC 304 SECTION E KIDNEY/RENAL CHAIRED BY: CARLA ELLIS AND AGNES FOGO 1:00 The Spectrum of Kidney Diseases Associated with Hepatitis C Virus Infection in the Era of Improved Antiviral Treatment (1629) Shunhua Guo, Agnes Fogo. Vanderbilt University Medical Center, Nashville, TN. 1:15 The Spectrum of Podocyte and Parietal Epithelial Cells (PEC) Activation in Nonsclerosed Glomeruli in Focal Segmental Sclerosis (FSGS) (1651) Haichun Yang, Miguel F Palma Diaz, Giovanna Giannico, Sheau-Chiann Chen, Sharon Philips, Charles Jennette, Arthur H Cohen, James M Pullman, Vivette D Agati, Charles E Alpers, Agnes Fogo. Vanderbilt University Medical Center, Nashville, TN; UCLA David Geffen School of Medicine, Los Angeles, CA; University of North Carolina, Chapel Hill, NC; Wake Forest School of Medicine, Winston-Salem, NC; Montefiore Medical Center, Bronx, NY; Columbia University, New York, NY; University of Washington, Seattle, WA. 1:30 Reducing Inflammation and Oxydative Stress Reverses Established Glomerulosclerosis in Diabetic Kidney Disease (1628) Fabrizio Grosjean, Elena M Yubero-Serrano, Helen Vlassara, Gary E Striker, Fadi Salem. Mount Sinai Medical Center, New York, NY; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Reina Sofia University Hospital/University of Cordoba, Cordoba, Spain. 1:45 C3GN with a Severe Crescentic Phenotype (1643) Aishwarya Ravindran, Fernando C Fervenza, Mariam P Alexander, Sanjeev Sethi. Mayo Clinic, Rochester, MN. 2:00 Understanding l6 Light Chain Fibrillogenesis/ translational Application to Renal Biopsy (1630) Guillermo A Herrera, Elba A Turbat-Herrera, Jiamin Teng, Bing Liu, Francisco J Rodriguez-Alvarez, Luis del Pozo-Yauner. Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA; National Institute of Genomic Medicine, Mexico, Mexico. 2:15 Immune Complex Kidney Disease and HIV-Associated Nephropathy in Renal Allografts of HIV Infected Patients (1653) Shuling Zheng, Stephen C Ward, Kenneth T Hughes, Fadi Salem. Icahn School of Medicine at Mount Sinai, New York, NY. 2:30 Chimerism in Allograft Kidney Tumors in Transplanted Patients (1616) Hussein Alnajar, Sahr Syed, David Cimbaluk, Lela Buckingham, Paolo Gattuso. Rush University Medical Center, Chicago, IL. 2:45 Non-Neoplastic Kidney Chronic Injury Score Predicts Post-Operative Renal Function in Radical Nephrectomy Specimens (1638) Miao Lu, Deepak K Pruthi, Corey Knickle, Thomas B McGregor, Ian W Gibson. University of Manitoba, Winnipeg, MB, Canada; University of Texas Health Sciences Centre, San Antonio, TX. 3:00 BREAK CC 301 SECTION F HEAD & NECK CHAIRED BY: JUSTIN A BISHOP AND HENRY CRIST 1:00 SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma: A Series of 33 Cases Expanding the Morphological and Clinicopathological Spectrum of a Recently Described Entity (1282) Abbas Agaimy, Arndt Hartmann, Cristina R Antonescu, Simion Chiosea, Samir K El-Mofty, James Lewis, Stacey E Mills, Ann Sandison, Roderick HW Simpson, William H Westra, Justin A Bishop. University Hospital of Erlangen, Erlangen, Germany; Memorial Sloan Kettering Cancer Center, New York, NY; University of Pittsburgh Medical Center, Pittsburgh, PA. 136

197 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 1:00 PM - Exhibit 3:00 PM Hall 1 1:15 Sinonasal HPV-Related Carcinoma with Adenoid Cystic Carcinoma-Like Features: An Expanded Series of 34 Cases (1292) Justin A Bishop, Simon Andreasen, Martin Bullock, Douglas Gnepp, Carmen Gomez, Alessandro Franchi, Katalin Kiss, James Lewis, Kelly Magliocca, Ann Sandison, William H Westra. Johns Hopkins, Baltimore, MD; Copenhagen University, Copenhagen, Denmark; Dalhousie University, Halifax, Canada; University Pathologists, Fall River, MA; University of Miami, Miami, FL; University of Florence, Florence, Italy; Vanderbilt, Nashville, TN; Emory, Atlanta, GA; Charing Cross Hospital, London, United Kingdom. 1:30 Recurrent IDH2 R172X Mutations Define Sinonasal Undifferentiated Carcinoma (1310) Vickie Y Jo, Nicole G Chau, Jason L Hornick, Jeffrey F Krane, Lynette M Sholl. Brigham and Women s Hospital and Harvard Medical School, Boston, MA; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA. 1:45 Novel Mutations in Sinonasal Squamous Cell Carcinoma Detected Using Next Generation Sequencing (1320) Gordon AG McKenzie, Taneisha McFarlane, Sandra Hing, Geraldine Thomas, Ann Sandison. Imperial College London, London, United Kingdom; Hull and East Yorkshire Hospitals NHS Trust, Hull, East Yorkshire, United Kingdom. 2:00 Subsets of Epithelial Myoepithelial Carcinoma Defined by Morphologic Evidence of Pleomorphic Adenoma, PLAG1 or HMGA2 Rearrangements, and Genetic Alterations (1300) Soufiane El Hallani, Diana Bell, Isabel Fonseca, Adel Assaad, Raja R Seethala, Lester DR Thompson, Simion Chiosea. University of Pittsburgh, Pittsburgh, PA; MD Anderson, Houston, TX; Instituto Português De Oncologia De Francisco Gentil, Lisboa, Portugal; SCPMG, Woodland Hills, CA; Virginia Mason Hospital, Seattle, WA. 2:15 PARP1 Overexpression in Merkel Cell Carcinoma and Its Potential Clinical Implications (1290) Diana Bell, Shirley Y Su, Bonnie Glisson, Merril Kies, Victor G Prieto, Renata Ferrarrotto. MD Anderson Cancer Center, Houston, TX. 2:30 A First Look at the Genomic Landscape of Non- Metastatic Cutaneous Squamous Cell Carcinoma (1305) Ruta Gupta, Catherine Zilberg, Matthew Lee, Bruce Ashford, Jonathan Clark, Marie Ranson, Bing Yu, Sandra O Toole. The Chris O Brien Lifehouse (LH), Camperdown, New South Wales, Australia; Royal Prince Alfred Hospital (RPAH), Camperdown, New South Wales, Australia; Illawarra Health and Medical Research Institute (IHMRI), Wollongong, New South Wales, Australia. 2:45 Beyond the Percentages of PD-L1-Positive Tumor Cells: Induced versus Constitutional PD-L1 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma (1334) Theresa Scognamiglio, Yao-Tseng Chen. Weill Cornell Medical College, New York, NY. 3:00 BREAK CC 302 SECTION G QUALITY ASSURANCE CHAIRED BY: VINITA PARKASH AND ERICKA OLGAARD 1:00 High Rate of Inappropriate Orders for a Hematologic Malignancy Next-Generation Sequencing Panel Does Not Improve with Educational Interventions: A Role for Continued Test Utilization Management (2054) Thomas D Lee, Sureni Mullegama, Sheeja T Pullarkat, Sarah Dry, Rena R Xian. UCLA, Los Angeles, CA. 1:15 Improving Test Utilization in Factor V Leiden Assessment (2050) Sean O Keenan, Kandice Marchant, Gary W Procop. Cleveland Clinic, Cleveland, OH. 1:30 Leaning Out the Clinical Trials Process: Optimizing the Last Hope in Cancer Care (2096) Ruan C Varney, Richard Zarbo. Henry Ford Health System, Detroit, MI. 1:45 Using Root Cause and Human Factors Analysis to Investigate and Reduce Errors in Pathology- A Pilot Project (2072) Vinita Parkash, John H Sinard. Yale University School of Medicine, New Haven, CT. 2:00 Root Cause Analysis of Bone Marrow Biopsy Processing to Increase Efficiency, Quality, and Interdisciplinary Communication (2029) Ya Cui, Jeffrey Whitman, Kristie L White. University of California, San Francisco, CA. 2:15 What Is the Optimal Flow Cytometric Screening Panel for Our Patients? An Evidence-Based Approach (2100) Dawn Williams, Christine G Roth. Baylor College of Medicine, Houston, TX. 2:30 Comparison of Breast Carcinoma Nottingham Grading by Glass Slides versus Digital Whole Slide Images: Variability Increases Using Digital Format (2032) Tara M Davidson, Mara H Rendi, Paul D Frederick, Tracy Onega, Kimberly H Allison, Ezgi Mercan, Tad T Brunyé, Linda G Shapiro, Donald L Weaver, Joann G Elmore. University of Washington, Seattle, WA; Dartmouth College, Hanover, NH; Stanford University, Stanford, CA; Tufts University, Boston, MA; University of Vermont, Burlington, VT. 137

198 ABSTRACTS PROFFERED PAPERS Day, Monday, Date, 2016 March 06, 0: AM - 0:00 1:00 PM - Exhibit 3:00 PM Hall 1 2:45 A One Slide GI Biopsy Protocol Does Not Impact Clinical Care and Provides Substantial Cost/Time Savings (2039) Sarah Dry, Bita V Naini. UCLA, Los Angeles, CA. 3:00 BREAK CC 303 SECTION H ENDOCRINE CHAIRED BY: NICOLE A CIPRIANI AND THOMAS J GIORDANO 1:00 Examination of PHOX2B in Adult Neuroendocrine Neoplasms Reveals Relatively Frequent Expression in Pheochromocytomas and Paragangliomas, Rare Expression in Neuroendocrine Carcinomas, and No Expression in Neuroendocrine Tumors (588) John P Lee, Yin P Hung, Jason L Hornick, Andrew M Bellizzi. University of Iowa, Iowa City, IA; Brigham and Women s Hospital, Boston, MA. 1:15 Primary Thyroid Carcinoma with Low-Risk Histology and Distant Metastases: Clinico-Pathologic and Molecular Characteristics (616) Bin Xu, R Michael Tuttle, Mona Sabra, Ian Ganly, Ronald Ghossein. Memorial Sloan Kettering Cancer Center, New York, NY. 1:30 Pathologic Reporting of Tall Call Variant of Papillary Thyroid Cancer: Have We Reached Consensus? (582) Juan Hernandez-Prera, Rosalie Machado, Sylvia L Asa, Zubair Baloch, William Faquin, Ronald Ghossein, Virginia A LiVolsi, Ricardo V Lloyd, Ozgur Mete, Yuri Nikiforov, Lester DR Thompson, Andrew T Turk, Raja R Seethala, Saul Suster, Mark L Urken, Bruce M Wenig. Mount Sinai Beth Israel, New York, NY; University of Toronto, Toronto, Canada; University of Pennsylvania, Philadelphia, PA; Massachusetts General Hospital, Boston, MA; Memorial Sloan Kettering Cancer Center, New York, NY; University of Wisconsin, Madison, WI; University of Pittsburgh, Pittsburgh, PA; Southern California Permanente Medical Group, Woodland Hills, CA; Columbia University, New York, NY; Medical College of Wisconsin, Milwaukee, WI; Moffitt Cancer Center, Tampa, FL. 1:45 The Impact of Reclassification of Encapsulated Follicular Variant of Papillary Thyroid Carcinoma on the Risk of Malignancy in the Bethesda System for Reporting of Thyroid Cytopathology (580) Danielle Elliott Range, Grant Harrison, Xiaoyin S Jiang. Duke Health, Durham, NC. 2:00 Ancillary Molecular Testing of Cytologic Samples in the Setting of NIFTP (607) Kyle C Strickland, Markus Eszlinger, Ralf Paschke, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta. Brigham and Women s Hospital, Harvard School of Medicine, Boston, MA; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. 2:15 Prevalence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) in Thyroid Tumors with BRAF K601E Mutation (600) Dinesh Pradhan, Raja R Seethala, Simion I Chiosea, Marina N Nikiforova, Arivarasan Karunamurthy, N Paul Ohori, Yuri Nikiforov. University of Pittsburgh Medical Center, Pittsburgh, PA. 2:30 Should Subcentimeter Non-Invasive Encapsulated, Follicular Variant of Papillary Thyroid Carcinoma (NI- EFV PTC) Be Diagnosed as Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)? (581) Nada Farhat, Bin Xu, Ayse Mine Onernek, R Michael Tuttle, Benjamin Roman, Nora Katabi, Vania Nosé, Peter M Sadow, Giovanni Tallini, William Faquin, Ronald Ghossein. Memorial Sloan-Kettering Cancer Center, New York, NY; Sunnybrook Health Science Centre, Toronto, ON, Canada; Massachusetts General Hospital, Boston, MA; Bologna University School of Medicine, Bologna, Italy. 2:45 Distinctive Metabolic Signatures in Adrenocortical Tumorigenesis (579) Kai Duan, Hasan Gucer, Mehmet Kefeli, Sylvia L Asa, Daniel Winer, Ozgur Mete. University Health Network, University of Toronto, Toronto, ON, Canada; Recep Tayyip Erdogan University, Rize, Turkey; Samsun Ondokuz Mayis University, Samsun, Turkey. 138

199 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 BREAST PATHOLOGY 1 Invasive Lobular Carcinomas with PTEN Loss Have Increased PD-L1+ Tumor Infiltrating Lymphocytes (282) Elizabeth Thompson, Tamara L Lotan, Janis M Taube, Rebecca Asch-Kendrick, Aleksandra Ogurtsova, Haiying Xu, Rajni Sharma, Alan Meeker, Pedram Argani, Leisha A Emens, Ashley Cimino-Mathews. Johns Hopkins Hospital, Baltimore, MD. 2 The Immune Regulator Galectin 3 Is Expressed on Primary Breast Carcinomas and Their Tumor Infiltrating Lympocytes: Implications for Immune-Based Therapy (281) Elizabeth Thompson, Alan Meeker, Janis M Taube, Pedram Argani, Elizabeth Jaffee, Leisha A Emens, Ashley Cimino-Mathews. Johns Hopkins Hospital, Baltimore, MD. 3 Roles of PD-L1, PD-L2 and PD-1 in Triple Negative Breast Cancers: Perspective from an Asian Cohort (185) Jabed Iqbal, Joe Yeong, Bernett Lee, Jeffrey CT Lim, Timothy Tay Kwang Yo, Aye Aye Thike, Puay Hoon Tan. Singapore General Hospital, Singapore, Singapore; Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. 4 Increased FoxP3-Positive Tregs Augur Better Survival and Colocalize with Both CD8 + T-cells and CD20 + B-cells within the Microenvironment of Triple Negative Breast Cancer (184) Jabed Iqbal, Joe Yeong, Bernett Lee, Siew-cheng Wong, Jeffrey Chun Tatt Lim, Aye Aye Thike, Susan Swee Shan Hue, Puay Hoon Tan. Singapore General Hospital, Singapore, Singapore; SIGN, Singapore, Singapore. 5 Comparison of PD-L1, B7-H3, and PD-1 Expression in HIV Patients and Immunocompetent Patients with Breast Cancer (258) Stephanie Richards, Gary Rose, Paula Rosenblatt, David Riedel, Madhurima Koka, Kimberly Tuttle, Ashley Cellini, Olga Ioffe. University of Maryland School of Medicine, Baltimore, MD. 6 PDL-1 (Clone 28-8 and Clone 22C) Expression in HER2+ Breast Carcinoma: Correlation with Tumor Infiltrating Lymphocytes and Pathologic Variables (210) Yanchun Li, Hossam Jabbour, Xuan Peng, Song Yao, Mateusz Opyrchal, Li Yan, Thaer Khoury. Roswell Park Cancer Institute, Buffalo, NY. 7 Deep Learning Automated Segmentation of Tumor Infiltrating Lymphocytes in Breast Cancer Specimens (187) Nafiseh Janaki, Jon Whitney, Andrew Janowczyk, Anant Madabhushi, Stefanie Avril. University Hospitals Cleveland Medical Center, Cleveland, OH; Case Western Reserve University, Cleveland, OH. 8 CD206 Positive Macrophages in Axillary Lymph Nodes of Patients with Breast Adenocarcinoma Express PD-L1 (283) Alireza Torabi, Daniel Welder, Cynthia Perry, Frank H Wians. Texas Tech University Health Science Center, El Paso, TX. 9 PD-L1 Expression in Male Breast Carcinoma and Its Correlation with Patient Demographics, Histologic Grade and Prognostic/Predictive Markers. (104) Anand C Annan, Momin T Siddiqui, Sonal Bhimji- Pattni, Cynthia Cohen. Emory University School of Medicine, Atlanta, GA. 10 Pre-Operative Single-Fraction Radiotherapy for Breast Cancer Leads to Increased Tumor PD-L1 Expression by Transcriptome Sequencing (244) Edgardo R Parrilla Castellar, K Ramona Charaghvandi, Sara Abbott, David L Corcoran, Janet K Horton. Duke University Medical Center, Durham, NC; University Medical Center Utrecht, Ultrecht, Netherlands. 11 High CD44 Expression in Brain Metastases from Breast Cancer Suggests Role of Cancer Stem Cells (160) Kara Gawelek, Nicole Williams, Shaveta Vinayak, Huiping Liu, Vinay Varadan, Hannah Gilmore. Case Western Reserve University, Cleveland, OH; University Hospitals Cleveland Medical Center, Cleveland, OH; The Ohio State University, Columbus, OH. 12 Tissue Microarray (TMA) Based Immunohistochemical Studies of Lymphocyte-Specific Markers Yield Inaccurate Results (227) Patrick J McIntire, Paula Ginter, Lina Irshaid, Xiaoyan Cui, Zhengming Chen, Sandra J Shin. Weill Cornell Medicine, New York, NY. 13 PD-L1 in Breast Cancer: Comparative Analysis of Three Different Antibodies (190) Tejashree Karnik, Bruce Kimler, Fang Fan, Ossama Tawfik. The University of Kansas Medical Center, Kansas City, KS. 14 Immune Profiling of HER2 Positive TILs Rich Breast Cancer: Correlation with Response to Neoadjuvant Therapy (301) Fei Yang, Jaime Rodriguez-Canales, Barbara Mino, Elizabeth Mittendorf, Aysegul A Sahin, Yun Wu. MD Anderson Cancer Center, Houston, TX. 15 Stromal Density of Tumor-Infiltrating Lymphocytes (TILs): Challenging the 50% Threshold That Defines Lymphocyte Predominant Breast Cancer (LPBC) (136) Xiaoyan Cui, Paula Ginter, Patrick J McIntire, Lina Irshaid, Zhengming Chen, Sandra J Shin. Weill Cornell Medicine, New York, NY. 139

200 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 16 Tumor-Infiltrating Lymphocyte (TIL) Assessment Distilled into Two Binary Parameters in Triple-Negative Breast Cancer (TNBC) (137) Xiaoyan Cui, Patrick J McIntire, Paula Ginter, Lina Irshaid, Zhengming Chen, Sandra J Shin. Weill Cornell Medicine, New York, NY. 17 PD-1 and PD-L1 Expression in HER2-Positive Breast Carcinomas (289) Julianne M Ubago, Alexandra Larson, Mansooreh Eghtesad, Luis Z Blanco, Jennifer Pincus, Kalliopi P Siziopikou. Northwestern University Feinberg School of Medicine, Chicago, IL. 18 Correlation of Clinical and Pathologic Features in Pregnancy-Associated Breast Cancer (288) Julianne M Ubago, Mansooreh Eghtesad, Jennifer Pincus, Kalliopi P Siziopikou, Luis Z Blanco. Northwestern University Feinberg School of Medicine, Chicago, IL. 19 Biomarker Profile Before and After Neoadjuvant Chemotherapy (307) Jennifer Zeng, Andrea Hernandez, Farbod Darvishian. New York University Medical Center, NY, NY. 20 Assessment of Cell Density and Ki67 in Initial, Intermediate CNB and in Resection Specimen After Neoadjuvant Chemotherapy (203) Asel Kudaybergenova. Petrov Oncology Institute, Saint Petersburg, Russian Federation. 21 Phenotypic Alterations in Breast Cancer Associated with Neoadjuvant Chemotherapy: A Comparison with Baseline Rates of Change (172) Nosaibah Hariri, Andres A Roma, Vighnesh Walavalkar, Farnaz Hasteh, Oluwole Fadare. UCSD, San Diego, CA. 22 Are There Any Pathologic Features Associated with a Phenotypic Change After Neoadjuvant Chemotherapy in Breast Cancers? (173) Nosaibah Hariri, Oluwole Fadare. UCSD, San Diego, CA. 23 Do Tumor Characteristics Predict Changes in Breast Cancer Biomarkers Following Neoadjuvant Chemotherapy? (300) Zhaoying Xian, Alexander K Quinones, Gary Tozbikian, Debra L Zynger. The Ohio State University Medical Center, Columbus, OH. 24 Androgen Receptor Expression Is Higher in CK5/6 Negative versus CK5/6 Positive Triple-Negative Breast Cancers (308) Tao Zuo, Ali Cicek, Olivia L Snir, Yuanxin Liang, Malini Harigopal. Yale School of Medicine, New Haven, CT; Tufts Medical Center, Boston, MA. 25 Androgen Receptor Positive Triple Negative Breast Cancer (TNBC): Clinicopathologic and Prognostic Features (107) Kristine Astvatsaturyan, Yong Yue, Shikha Bose. Cedars Sinai Medical Center, Los Angeles, CA. 26 HER2 Intratumoral Heterogeneity Is Associated with Incomplete Response to Anti-HER2 Neoadjuvant Chemotherapy in HER2-Positive Breast Carcinoma (212) Zaibo Li, Hiroaki Nitta, Yanjun Hou, Peter Banks. Ohio State University, Columbus, OH; Ventana Medical Systems, Inc, Tucson, AZ. 27 BRCA1 Mutations Detected by Next-Generation Sequencing in Sporadic Breast Cancer with Medullary Histological Features Correlate with Hereditary Disease (291) Zsuzsanna Varga, Konstantin Dedes, Daniel Fink, Bernhard Pestalozzi, Holger Moch, Peter Wild, Markus Rechsteiner. Institute of Surgical Pathology, Zurich, Switzerland; Clinic of Oncology, Zurich, Switzerland; University Hospital Zurich, Zurich, Switzerland. 28 Apocrine Carcinomas Are a Distinct Subset of Androgen Receptor Positive (AR+) Triple Negative Breast Carcinomas (TNBC) (108) Kristine Astvatsaturyan, Yong Yue, Shikha Bose. Cedars Sinai Medical Center, Los Angeles, CA. 29 Expression of Met and Androgen Receptors in ER Negative Breast Cancer (99) Dalia Abouelfadl, Hebatallah A Amin, Noha N Yassen, Marwa E Shabana, Heba A Abdelal. National Research Center, Cairo, Egypt; Egyptian Forensic Authourity, Cairo, Egypt; Armed Forces Hospitals, Cairo, Egypt. 30 Expression of GATA 3, c-kit and GCDFP in Benign and Malignant Apocrine Lesions of the Breast (299) Xinyu Wu, Ali Cicek, Omeed Hafez, Julian Berrocal, Malini Harigopal. Yale University, New Haven, CT. CYTOPATHOLOGY 31 The Value of Cytological Examination in Cervical High Grade Squamous Lesions Undetected by Human Papillomavirus (HPV) Molecular Testing (368) Evan J Fowle, Priscila Andrade, Rajmohan Murali. Memorial Sloan Kettering Cancer Center, New York, NY. 32 Follow Up Outcome in Patients with LSIL Pap Cytology and Aptima HR-HPV Testing Results (357) Kossivi Dantey, Xin Li, Xin Zhao, Jonee Matsko, Chengquan Zhao. University of Pittsburgh Medical Center, Pittsburgh, PA. 140

201 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 33 High Grade Intraepithelial Lesion on High-Risk HPV Negative Patients: Why We Still Need the Pap Test! (460) Hongxia Sun, Ramya Masand, Shobhanaben J Patel, Vijayalakshmi Padmanabhan. Baylor College of Medicine, Houston, TX. 41 The Prevalence and Distribution of Genotypes of High- Risk Human Papilloma Virus in Women Older Than 65 Years (431) Michael A Prochaska, Katie Dennis, Rashna Madan, Ossama Tawfik, Fang Fan. University of Kansas Medical Center, Kansas City, KS. 34 Comparison of Clinical, Histologic Features and Biomarkers of High Grade Cervical Intraepithelial Neoplasia (CIN3) False Negatives Missed by Either Human Papilloma Virus (HPV), Cytology or Both (470) Jessica Tracht, Isam-Eldin Eltoum. University of Alabama at Birmingham, Birmingham, AL. 35 Comparison of Aptima, Cervista and Hybrid Capture 2 HPV Detection and Follow Up Results in Patients with HSIL Paps in a Large Academic Women Center (337) Dayne Ashman, Chengquan Zhao. University of Pittsburgh Medical Center, Pittsburgh, PA. 36 Impact of Transformation Zone Component on the Efficacy of Anal Cytology (406) Dan Lu, David Chhieng, Michael Gaisa, Keith Sigel, Qiusheng Si. Icahn School of Medicine at Mount Sinai, New York, NY. 37 Cytological Screening for Anal Lesions and Correlation with Histology and HPV Status. A Hospital Series (355) Adrià L Dagà, Maria Teresa R Calvo, Natalia F Papaleo, Javier G Beltrán, Mar Iglesias Coma, Belen L Rubio, Francesc A Quitllet. Hospital del Mar. Parc de Salut Mar, Barcelona, Spain; Autonomous University of Barcelona, Barcelona, Spain. 38 Unsatisfactory Exfoliative Anal Cytology Samples: A 15-Year Experience with Histologic, Cytologic, and Molecular Follow-Up (392) Ruba Khattab, Emily McMeeken, Alan Taege, James Hekman, Jennifer A Brainard, Dawn Underwood, Charles D Sturgis. Cleveland Clinic, Cleveland, OH. 39 Anal Pap Smears: Five- Year Retrospective Review (422) Rochelle Nagales Nagamos, Melissa Stemmer, Cindy Steele, Kamal K Khurana. SUNY Upstate Medical University, Syracuse, NY. 40 Cytological Features of a Spectrum of Gastric Type Glandular Lesions of the Uterine Cervix in Pap Smear (350) Koping Chang, Chih-Fen Tan, Tsui-Lien Mao. National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan. 42 Comparing the Histologic Follow-Up Results of Positive HC2 HR HPV Test, Cervista HPV HR Assay and Aptima HR Assay for Women with ASC-US Cytology (486) Chengquan Zhao, Dinesh Pradhan, Michelle Stram. UPMC, Pittsburgh, PA. 43 Histopathologic Follow-Up and HC2 HPV Results in 2092 Patients with HSIL Pap Test in the Largest Women Hospital in China (465) Xiang Tao, Faye Gao, Xianrong Zhou, Li Wang, Long Sui, Chengquan Zhao. Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China; Washington Hospital Center, Washington, DC, DC; Magee-Women s Hospital of UPMC, Pittsburgh, PA. 44 Cytology-Histology Correlation of Atypical Glandular Cells on Routine Pap Test and the Role of HPV Testing (380) Heidi Holtorf, Isabella Luna, Dina Mody, Donna Armylagos, Eric Luna, Mary R Schwartz, Yimin Ge. Houston Methodist Hospital, Houston, TX; Texas Tech University, Lubbock, TX; BioReference Laboratories, Houston, TX; Weill Medical College of Cornell University, New York, NY. 45 Best Practice: High Risk HPV Test Alone or in Combination with Cervicovaginal Pap Test for Cervical Cancer Screening (452) Anwer Siddiqi, Rohit Sharma, Sania Shuja. University of Florida, Jacksonville, Jacksonville, FL; University of Washington, Seattle, WA. 46 Is Reporting of Normal Endometrial Cells in Women Greater Than 45 Years on Papanicolaou Test Necessary? (448) Shenon Sethi, Christine Rupcich, Ji-Weon Park. Rush University Medical Center, Chicago, IL. 47 Validation of a New Methanol Based Fixative for Cervical Cytology (399) Katia RM Leite, Thais Silva, Bruna Naum, Flavio C Canavez, Juliana MS Canavez, Luiz Heraldo A Camara- Lopes. Laboratorio Genoa, Sao Paulo, Brazil; University of Sao Paulo Medical School, Sao Paulo, Brazil. 48 ASCUS Cervical Cytology Report Rate and Histological Follow-Up Finding in China s Largest CAP-Certified Laboratory (489) BaoWen Zheng, Huaitao Yang, Jia You, Chengquan Zhao. Guangzhou Kingmed Diagnostics, Guangzhou, China; University Cincinnati College of Medicine, Cincinnati, OH; University of Pittsburgh Medical Center, Pittsburgh, PA. 141

202 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 49 LSIL Cervical Cytology Report Rate and Histological Follow-Up Finding in China (488) BaoWen Zheng, Huaitao Uamg, Guijian Wei, Chengquan Zhao. Guangzhou Kingmed Diagnostics, Guangzhou, China; University Cincinnati College of Medicine, Cincinnati, OH; University of Pittsburgh Medical Center, Pittsburgh, PA. 50 Correlation of Unsatisfactory Liquid-Based Papanicolaou Tests with HPV Positive Status: Retrospective Study in a Large Community-Based Clinical Practice (363) Elena Enbom, Evan Yung, Juan Felix. LAC+USC Medical Center, Los Angeles, CA. 51 Morphologic Variation in Low Grade Squamous Intraepithelial Lesions (LSIL) Is Independently Correlated with Subsequent High-Grade SIL (HSIL) at Cervical Biopsy and High-Risk Human Papilloma Virus (HR-HPV) Positivity (346) Sarah Carroll, Christopher Hartley, Suzanne Selvaggi, Aparna Mahajan. University of Wisconsin Hospital and Clinics, Madison, WI. 52 Clinical Significance of LSIL-H (LSIL with Coexistent ASC-H) in Pap Smears; a Two-Year Analysis of the Positive Predictive Value for Histological High-Grade Lesions Among LSIL, LSIL-H and ASC-H (423) Shuang Niu, Kyle Molberg, Elena Lucas. University of Texas Southwestern Medical Center, Dallas, TX; Parkland Health and Hospital System, Dallas, TX. 53 Underdiagnosis of HSIL on PAP Smears Due to Variant LSIL-Like Morphology in Non 16/18 HPV Infections (413) Ramya Masand, Barrett Lawson, Derek Danner, Matthew Anderson, Vijayalakshmi Padmanabhan, Ninad M Patil. Baylor College of Medicine, Houston, TX. 54 A Case for Coning the Cervix in Hysterectomies Performed for Benign Conditions in Patients with a Prior ASCUS Pap Test (421) Shima Mousavi, Neda Zarrin-Khameh, Ramya Masand, Vijayalakshmi Padmanabhan. Baylor College of Medicine, Houston, TX. 55 Metastatic Neoplasms to the Pancreas Diagnosed by Fine Needle Aspiration: A 10-Year Experience from a Tertiary Medical Center (481) Ya Xu, Rodolfo Laucirica, Neda Zarrin-Khameh. Baylor College of Medicine, Houston, TX. 56 Malignancy Risk Associated with the Diagnostic Categories Proposed by the Papanicolaou Society of Cytopathology for Pancreatobiliary Specimens: An Institutional Experience (400) Jenna Lewis, Thomas Joyal, Claudia Rojas, Carmen Gomez, Darcy A Kerr, Merce Jorda, Monica Garcia- Buitrago. University of Miami/Jackson Memorial Hospital, Miami, FL. 57 Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression in Pancreatic Neuroendocrine Tumors from Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) Specimens Correlate with Poor Patient Survival (467) Brian Theisen, Justin L Roncaioli, Roderick J O Sullivan, Kevin McGrath, Randall E Brand, Herbert J Zeh, Jennifer S Chennat, Kenneth E Fasanella, Asif Khalid, Georgios I Papachristou, Adam Slivka, Marina N Nikiforova, Melissa Hogg, Aatur D Singhi. University of Pittsburgh Medical Center, Pittsburgh, PA. 58 Cytologic Features of Undifferentiated Carcinoma with Osteoclast-Like Giant Cells (U-OGCa) of Pancreas; a Multi-Institutional Clinicopathologic Review of 14 Cases (382) Kim HooKim, Takashi Muraki, Bahar Memis, Rondell Graham, Jiaqi Shi, Daniela Allende, David Schaeffer, Volkan Adsay, Michelle D Reid. T. Jefferson Uni, Philadephia, PA; Emory Uni, Atlanta, GA; Mayo Clin, Rochester, MN; Clev Clin, Cleveland, OH; U of Michigan, Ann Arbor, MI; Vancouver Gen Hosp, Vancouver, Canada. 59 Fine Needle Aspiration Cytology of Hepatic Metastases of Neuroendocrine Tumors: A 20-Year Retrospective, Single Institutional Study (442) Omer Saeed, Harvey Cramer, Xiaoyan Wang, Howard Wu. Indiana University School of Medicine, Indianapolis, IN. 60 Pancreatic Surgical Resections with False-Positive Cytology Results: A Ten-Year Single Institution Retrospective Review (329) Daniel W Abbott, Bryan Hunt, Tamar Giorgadze, Kiyoko Oshima. Medical College of Wisconsin, Milwaukee, WI. 61 Endoscopic Ultrasound Guided Fine Needle Aspiration vs Fine Needle Biopsy of Pancreatic Lesions: A Retrospective Review Comparing Diagnostic Accuracy and Outcomes (419) Elizabeth Morency, Jamie Slade, John Sir Philip, Ritu Nayar. Northwestern Memorial Hospital, Chicago, IL. 142

203 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 62 Performance of Papanicolaou Society of Cytopathology (PSC) Guidelines with EUS Correlation in Resected IPMNs (338) Bridget S Banach, Tatjana Antic, Mary Buschmann, Ricardo R Lastra, Jeffrey Mueller, Uzma Siddiqui, Ward Reeves, Kevin Roggin, Irving Waxman, Shu-Yuan Xiao, Namrata Setia. University of Chicago, Chicago, IL. 69 Pathology Is Relevant, but We Don t Want to Do It. Medical Student Attitudes to Pathology Teaching and Understanding of Pathologists (566) Joanna C Walsh, Jessica Padgett, Michele M Weir, Saad Chahine. Western University / London Health Sciences Centre, London, ON, Canada; Western University, London, ON, Canada. 63 Prognostic Relevance of Pancreatic Neuroendocrine Tumor Grading on EUS-FNA (478) Birgit Weynand, Laure Boutsen, Ivan Borbath, Anne Jouret-Mourin. UZ Leuven, Leuven, Belgium; Cliniques universtitaires St Luc, Brussels, Belgium; Cliniques universitaires St Luc, Brussels, Belgium. 64 Sharkcore Needles for Pancreatic EUS-FNAB A Comparison of Cytologic and Histologic Preparations (458) Philippe Stephenson, Gary May, Christopher Teshima, Jeffrey D Mosko, Catherine Streutker. St-Michael s Hospital, Toronto, ON, Canada. 65 Poor Performance of Bile Duct Brushings (BDBs) Is Mostly Attributable to Suboptimal Sampling but Interpretative Challenges Are Also a Factor: A Comparative Analysis of Specimens Procured by Gastroenterologists vs Those Obtained from Surgical Resection Specimens (432) Michelle D Reid, Bahar Memis, Ezgi Hacihasanoglu, Vaidehi Avadhani, Uma Krishnamurti, Adeboye O Osunkoya, Alyssa Krasinskas, Krisztina Z Hanley, Rebecca Nash, Michael M Goodman, Volkan Adsay. Emory Uni., Atlanta, GA. 66 Fine-Needle Aspiration Cytology of Histology- Confirmed Pancreatic Cystic Lesions (353) Euna Choi, Harvey Cramer, Howard Wu. Indiana University, Indianapolis, IN. 67 For Diagnosis of Liver Masses, Fine Needle Aspiration versus Needle Core Biopsy: Which Is Better? (462) Liye Suo, Ruby Chang, Vijayalakshmi Padmanabhan, Shilpa Jain. Baylor College of Medicine, Houston, TX; Ben Taub General Hospital, Houston, TX. EDUCATION 68 Creating Pathologists from a Post-Sophomore Externship: 15 Years and 98 Externs at an Academic Pathology Department (552) Alexandra Isaacson, Robert Robinson, Megan Samuelson. University of Iowa Hospitals and Clinics, Iowa City, IA. 70 Integrating Neuropathology with the Neurology and Psychiatry Clinical Clerkships: The Future of the Undergraduate Medical Education (559) Douglas A Mata. Brigham and Women s Hospital, Boston, MA. 71 Resident Perceptions of Training and Interest in Academic Pathology Practice (564) Swati Satturwar, Xiangming Fang, Peter Kragel, Ann Sutton. Brody School of Medicine at East Carolina University, Greenville, NC; East Carolina University, Greenville, NC. 72 Mentoring Residents in Academic Centers, the Cleveland Clinic Experience (543) Daniela Allende, Deborah Chute, Carol Farver. Cleveland Clinic, Cleveland, OH. 73 Can Pathology Skills Be Learnt Exclusively Through Online Resources?: MOOC for PAPs A Massive Open Online Course to Raise Pap Smear Cytoscreener Workforce in Low and Middle Income Countries (549) Rajan Dewar, Rosemary H Tambouret. University of Michigan, Ann Arbor, MI; Udhavum Ullangal NGO, Chennai, Tamilnadu, India; Massachusetts General Hospital & Harvard Medical School, Boston, MA. 74 A Feedback-Based Training Module Improves Tumor Cellularity Estimation for Molecular Testing (567) Julianna J Weiel, Oscar Silva, Kelly L Mooney, Chieh- Yu Lin, Christian A Kunder. Stanford University School of Medicine, Stanford, CA. 75 RE-AIMing Education with Interactive Review Software to Increase Resident Knowledge Retention (558) Anthony Martinez, Christina Dean, Drew Davis, Krisztina Z Hanley. Emory University, Atlanta, GA. 76 Developing Multimedia Resources Using Camtasia Studio 8 to Teach Pathology in the Era of Subspecialized Residency Education (554) Priyadarshini Kumar, Xuemo Fan. Cedars Sinai Medical Center, Los Angeles, CA. 77 pathcast: A Model for Pathology Education Using Web- Based Live Video Streaming (555) Emilio Madrigal, Abul Ala Syed Rifat Mannan, Shyam Prajapati, Neil Theise. Mount Sinai Health System, New York, NY. 143

204 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 78 #PathJC: The Founding and Success of the First Twitter Pathology Journal Club (551) Maren Fuller, Jerad M Gardner, Genevieve M Crane, Sean R Williamson, Simon Chiosea, Christina A Arnold, Michael A Arnold, Matthew J Wasco, Xiaoyin S Jiang. Houston Methodist, Houston, TX; UAMS, Little Rock, AR; UTSW, Dallas, TX; Henry Ford Health, Detroit, MI; UPMC, Pittsburgh, PA; OSU, Columbus, OH; Nationwide Children s Hospital, Columbus, OH; St Joseph Mercy Hospital, Ann Arbor, MI; Duke Health, Durham, NC. 79 The Use of Screencasts with Embedded Virtual Microscopy Cases to Teach Pulmonary Pathology in the Era of Subspecialized Residency Education (568) Mary Wong, Alberto M Marchevsky. Cedars-Sinai Medical Center, Los Angeles, CA. 80 Whole Slide Digital Imaging in Pathology Resident Education (548) Laura Craig-Owens, Joseph T Roland, Emily Reisenbichler. Vanderbilt University, Nashville, TN. 81 Interventions in Pathology Education: A Systematic Review of the Tools Used to Measure Student Performance (565) Geoffrey Talmon, Sarah McBrien, Daniel Reiff, Andrew Braith, Erika Fennen, Yanwei Liu, Jonathan Ryder, Paige Scholar, Emily Zurbuchen. University of Nebraska Medical Center, Omaha, NE. 86 Improving Patient-Pathologist Interactions Using Structured Communication Training for Pathologists- A Pilot Experience (545) Veerle Bossuyt, Alan Kliger, Vinita Parkash. Yale University School of Medicine, New Haven, CT; Yale New Haven Hospital, New Haven, CT. 87 Slide Sessions Led by Upper Level Residents Are a Useful Tool to Introduce First Year Residents to Surgical Pathology (560) Chelsea Mehr, Lauren E Schwartz. Hospital of the University of Pennsylvania, Philadelphia, PA. 88 A Survey of Pathologists and Learners of Pathology on Pathology Information Consumption (544) Michael Bonert, Mitchell S Wachtel, Jens Schittenhelm, Martin Bonert, Winnie Luong, Seshadri Thirumala, Asghar Naqvi. McMaster University, Hamilton, Canada; Texas Tech University, Lubbock, TX; University of Tübingen, Tübingen, Canada; University Health Network, Toronto, Canada; City of Toronto, Toronto, Canada; Ameripath- Covenant Medical Center, Lubbock, TX. 89 Images in Pathology: Sketches from the Montreal General Hospital (550) Linnea Duke, Kelli Sturkenboom, Francois Dansereau, Mary Hunter, Richard Fraser. Montreal University Health Center, Montreal, QC, Canada; McGill University, Montreal, QC, Canada. 82 Strategic Approach to Restructuring Surgical Pathology (SP) Resident Education in a Subspeciality (SS) Practice Model (556) Aparna Mahajan, Suzanne Selvaggi, Robert Corliss, Sara Gross, Erik Ranheim. Univ. of Wisconsin, Madison, WI. 83 Reporting of Newly Adopted World Health Organization (WHO) 2016 Classification Nomenclature for Testicular Tumors by Pathologists (561) Mohamed Mustafa, Joseph Sanfrancesco, Liang Cheng, David Grignon, John N Eble, Thomas M Ulbright, Muhammad Idrees. Indiana University School of Medicine, Indianapolis, IN. 84 MAP-IT Program to Enhance Professionalism in Pathology Residency Training (563) Sudarshana Roychoudhury, Michael J Esposito. Hofstra Northwell Health School of Medicine, New Hyde Park, NY. 85 Restructuring Resident Teaching Curriculum: An Institutional Experience (557) Abul Ala Syed Rifat Mannan, Malary Mani, Shyam Prajapati, Emilio Madrigal, Mark T Friedman. Mt Sinai Health System, New York, NY. GENITOURINARY PATHOLOGY 90 SERPINE1 Is Associated with Prostate Cancer Bone Metastases (890) Inés de Torres, Jordi Temprana, Douglas Sanchez, Juan Morote, Santiago Ramon y Cajal, Mireia Olivan, Marta Garcia. Hospital Universitari Vall d Hebron and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Group of Biomedical Research in Urology, Vall d Hebron Research Institute (VHIR) and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. 91 Comparative Analysis of Histologic and Molecular Features of MRI-Visible and MRI-Invisible Gleason Score 3+4=7 Prostate Cancer (1085) Helene Yilmaz, Andrei Purysko, Zaid Haddad, Mandeep Takhar, Kasra Yousefi, Nicholas G Erho, Beatrix Palmer-Arontsen, Elai Davicioni, Jesse K McKenney, Christopher Przybycin, Eric A Klein, Cristina Magi- Galluzzi. Douglass Hanly Moir Pathology, Sydney, Australia; Cleveland Clinic, Cleveland, OH; GenomeDx Biosciences, Vancouver, Canada; Glickman Urological Institute, Cleveland, OH. 144

205 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall 1 92 Diagnostic Efficacy of 12 Core Systematic Prostate Biopsy versus Multiparametric MRI with Image Targeted Biopsy: A Retrospective Review of 133 Patients (1080) Richard Wong, Donna Hansel, Ahmed Shabaik. University of California San Diego, San Diego, CA. 93 Treatment Choices in Patients Undergoing Multiparametric MRI/Ultrasound Fusion Biopsy Compared to Standard Biopsy (1041) Benjamin Saylor, Soroush Rais-Bahrami, Jeffrey Nix, Jennifer Gordetsky. The University of Alabama at Birmingham, Birmingham, AL. 94 Detection of Clinically Significant Prostatic Adenocarcinoma in Patients with Targeted MRI Guided Prostate Needle Core Biopsies: Critical Role in Patients on Active Surveillance (911) Rachel Geller, Brianna L Vey, Sherif G Nour, Kareem Elfatairy, Adeboye O Osunkoya. Emory University School of Medicine, Atlanta, GA. 95 Clinicopathologic Characteristics of Patients Undergoing Prostate Core Biopsy with High-Risk (PI- RADS 5) Lesions by Multiparametric Prostate Magnetic Resonance Imaging (909) Joel Friedman, Aaron M Udager, Nicole Curci, Chandy Ellimoottil, Rohit Mehra, Scott A Tomlins, Jeffrey S Montgomery, John Wei, Matthew Davenport, Angela Wu, Lakshmi P Kunju. University of Michigan Health System, Ann Arbor, MI. 96 RNA Sequencing of Patient Matched Pre-Androgen Deprivation Therapy and Post-Androgen Deprivation Therapy Prostate Cancer Identifies Mechanisms of Progression to Castration-Resistant Prostate Cancer (988) Carlos S Moreno, Felipe O Giuste, Kathryn L Pellegrini, Nitya V Sharma, Veronique Ouellet, Dominique Trudel, Anne-Marie Mes-Masson, John A Petros, Fred Saad, Adeboye O Osunkoya. Emory University School of Medicine, Atlanta, GA; McGill University, Montreal, QC, Canada; University of Montreal, Montreal, QC, Canada. 98 Validation of Gene Expression Signatures for Genomic Identification of Neuroendocrine Prostate Cancer (930) Samar Hegazy, Alexander W Wyatt, Jonathan Lehrer, Hatem Abou Ouf, Mohammed Alshalalfa, Ewan A Gibb, Beatrix Palmer-Arontsen, Nicholas G Erho, Elai Davicioni, Tamara L Lotan, Harrison Tsai, Tarek A Bismar. University of Calgary, Calgary, AB, Canada; University of British Columbia, Vancouver, BC, Canada; GenomeDx Biosciences Inc, Vancouver, BC, Canada; Johns Hopkins School of Medicine, Baltimore, MD. 99 Atypical Intraductal Proliferation and Intraductal Carcinoma of the Prostate on Core Needle Biopsy: A Comparative Clinicopathological and Molecular Study with Proposal to Expand Morphological Spectrum of Intraductal Carcinoma (1046) Rajal B Shah, Jiyoon Yoon, Gang Liu, Wei Tian. Miraca Life Sciences Research Institute, Irving, TX; University of Toledo, Toledo, OH. 100 Cribriform/Intraductal Carcinoma, a Candidate Predictor of Response to Neoadjuvant Treatment with Novel Androgen Inhibitors in Localized High Risk Prostate Cancer (1064) Patricia Troncoso, Elsa Li-Ning-Tapia, John W Davis, Xuemei Wang, Ina Prokhorova, Louis Pisters, Curtis Pettaway, Eleni Efstathiou. The University of Texas MD Anderson Cancer Center, Houston, TX. 101 The Use of the Composit Biopsy Grade Score in the Outcome Prediction for Radical Prostatectomy (971) Xunda Luo, Nirag Jhala, Huaqing Zhao, Jasvir S Khurana. Temple University Hospital, Philadelphia, PA; Lewis Katz School of Medicine, Temple University, Philadelphia, PA. 102 Association of Genomic Prostate Scores (GPS) with Prostatectomy Rates and Pathology at the Time of Prostatectomy (919) Nancy Greenland, Bradley Stohr, Jeffry Simko. University of California, San Francisco, San Francisco, CA. 97 Should Gleason Score 6 Prostate Cancer Be Renamed as Not Cancer? Incidence of Extra-Prostatic Extension at Radical Prostatectomy (RP) with Pure Gleason Score 3+3=6 Cancer (928) Oudai Hassan, Jonathan I Epstein. Johns Hopkins University, Baltimore, MD. 103 Immunohistochemical Evaluation of NKX3.1 Expression in Prostatic Ductal Adenocarcinomas (964) Haiyan Liu, Myra L Wilkerson, Fan Lin. Geisinger Medical Center, Danville, PA. 104 NKX3.1 and PSMA Are Reliable Markers for Prostatic Carcinoma in Bone Metastasis After Decalcification (920) Sergei R Guma, Jonathan Melamed, Ming Zhou, Fang- Ming Deng. New York University Medical Center, New York, NY. 145

206 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Nuclear Grade Is an Independent Predictor of Recurrence in Prostate Carcinoma (912) William R Gesztes, Allen P Burke, Daniel J Kim, Inger L Rosner, Jennifer Cullen, Huai-Ching Kuo, Yongmei Chen, Shiv K Srivastava, Isabell Sesterhenn. Center for Prostate Disease Research (CPDR), Rockville, MD; Joint Pathology Center (JPC), Silver Spring, MD; Walter Reed National Military Medical Center (WRNMNC), Bethesda, MD. 106 Comprehensive Determination of Prostate Tumor ETS Gene Status in Clinical Samples Using the CLIA Decipher Assay (1056) Alba FC Torres, Mohammed Alshalalfa, Scott A Tomlins, Nicholas G Erho, Ewan A Gibb, Jijumon Chelliserry, Lony Lim, Lucia LC Lam, Elai Davicioni, Kasra Yousefi, Angelo M De Marzo, Ashley E Ross, George J Netto, Edward M Schaeffer, Tamara L Lotan. Johns Hopkins School of Medicine, Baltimore, MD; GenomeDx Biosciences, Vancouver, BC, Canada; University of Michigan, Ann Arbor, MI; Northwestern University, Chicago, IL. 107 Disappearing Prostate Cancer on Template Biopsy. A Pathological and Radiological Study (858) Luis Beltran, Yen Zhi Tang, Francis Chinegwundoh, Daniel Berney. Barts Health, London, United Kingdom. 108 Evaluation of Tumor Morphologies at Radical Prostatectomy in High Risk Gleason Score 9 Prostate Cancer Diagnosed at TRUS-Guided Biopsy (1048) Jordan Sim, Nicola Schieda, Susan J Robertson, Rodney H Breau, Chris Morash, Eric C Belanger, Trevor A Flood. The Ottawa Hospital, Ottawa, ON, Canada; University of Ottawa, Ottawa, ON, Canada. 109 Glucocorticoid Receptor Expression Is Highly Prevalent in Primary Untreated Prostate Carcinoma (993) Daniel Nava Rodrigues, Gunes Guner, Igor Vidal, Ines Benedetti, Ibrahim Kulac, Jessica Hicks, Qizhi Zheng, Johann De Bono, Angelo M De Marzo. Johns Hopkins University, Baltimore, MD; University of Cartagena, Cartagena, Colombia; The Institute of Cancer Research, London, United Kingdom. 110 Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer (996) Anne Offermann, Johannes Braegelmann, Niklas Kluemper, Stefan Duensing, Maria Svensson, Zaki Shaikhibrahim, Jutta Kirfel, Sven Perner. Pathology, University Hospital of Luebeck and Research Center Borstel, Luebeck, Germany; Urology, University of Heidelberg, Heidelberg, Germany; Department of Research and Education, Örebro, Sweden. 111 How Useful Is MRI Guidance in Detecting Prostate Cancer versus Systematic Biopsy A Single Institution Experience Based on Evaluation of >1,000 Biopsies (936) Ian Hughes, Vamsi Parimi, Joseph Yacoub, Gopal Gupta, Stefan Pambuccian, Maria M Picken. Loyola University Medical Center, Maywood, IL. 112 Comparison of Standard and MRI Targeted Biopsy in Anterior-Predominant Prostate Cancer (1000) Yu-Ching Peng, Ying Wang, Hongying Huang, Peng Lee, Jonathan Melamed, Ming Zhou, Fang-Ming Deng. NYU Langone Medical Center, New York, NY. 113 NKX3.1 Is the Most Sensitive Immunohistochemical Marker in Identifying Metastatic Prostatic Carcinomas (965) Haiyan Liu, Myra L Wilkerson, Fan Lin. Geisinger Medical Center, Danville, PA. 114 Impact of Cribriform Architecture in Low Volume Gleason Score (GS) 3+4=7 or Grade Group (GG) 2 Prostate Cancers in Radical Prostatectomies (RP) (876) Bonnie Choy, Shane M Pearce, Blake B Anderson, Gladell P Paner. University of Chicago, Chicago, IL. 115 Prostate Neuroendocrine Tumors: Clinicopathological Study of 15 Cases with Emphasis on the Neuroendocrine Tumors of the Intermemdiate Grade and Overlapping Features (1089) Yani Zhao, Fang-Ming Deng, Hongying Huang, Peng Lee, Jonathan Melamed, Ming Zhou, Ming Zhou. New York University Langone Medical Center, New York, NY. 116 Gleason Score 3+4=7 Prostate Carcinomas Detected by MRI-Targeted Biopsies Contain Higher Percentage of Pattern 4 and Are Less Likely to Be Upgraded in Radical Prostatectomies (1090) Yani Zhao, Fang-Ming Deng, Hongying Huang, Peng Lee, Jonathan Melamed, Ming Zhou. New York University Langone Medical Center, New York, NY. 117 GATA3 Positivity in Benign Radiated Prostate Glands: A Potential Diagnostic Pitfall (953) Armen H Khararjian, Jonathan I Epstein, Sara E Wobker. The Johns Hopkins Hospital, Baltimore, MD; University of North Carolina, Chapel Hill, NC. 118 GATA3 Expression in Benign Prostate Glands with Radiation Atypia: A Diagnostic Pitfall (893) David Dorn, Wei Tian, Rajah Shah, Ronald D Sanders, Shi Wei, Jennifer Gordetsky. Miraca Life Sciences, Irving, TX; The University of Alabama at Birmingham, Birmingham, AL. 146

207 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Clinical Significance of Tertiary Pattern 4 in Gleason 3+3=6 Adenocarcinoma of the Prostate (856) Nicholas Barna, Mark Ettel, Fei Chen, Peng Lee, Hongying Huang, Jonathan Melamed, Ming Zhou, Fang-Ming Deng. New York University Langone Medical Center, New York, NY. 120 Clinicopathologic Features of Patients without Biochemical Recurrence More Than 5 Years Following Radical Prostatectomy with Limited Tumor, pt2, and Negative Margins: Comparison of Tumors with Gleason Score 3+3=6 vs 3+4=7 in the Surgical Specimen (864) Athanase Billis, Maisa M Quintal, Leandro LL Freitas, Larissa BE Costa, Bruna C Zaidan, Gabriel VBS Tabosa, Livia LA Azevedo, Amanda P Herculiani, Daniele M Losada, Karina S Araujo, Marcel A Asato, Gabriel LP Oliveira, Lucas QA Bastos, Ruana M Rocha. School of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil. 121 Characteristics of Initial Prostate Biopsies That Predict Repeat Biopsy Upgrade to Gleason 7 (1007) Saranya Prathibha, Kashika Goyal, Debra L Zynger. The Ohio State University Medical Center, Columbus, OH. 122 The Incidence of Intraductal Carcinoma of the Prostate Is Higher in Peripheral Zone Cancer Than in Transition Zone Cancer in Japanese Radical Prostatectomy Cohort (1040) Shun Sato, Hiroyuki Takahashi, Takashi Yorozu, Takahiro Kimura, Masahiro Ikegami. The Jikei University School of Medicine, Tokyo, Japan. 123 Temporal Trends in Prostatic Carcinoma Staging in a 23-Year Cohort of Men Treated with Radical Prostatectomy (871) Allen P Burke, William R Gesztes, Inger L Rosner, Stephen Brassell, Kevin R Rice, Shiv K Srivastava, Jennifer Cullen, Huai-Ching Kuo, Isabell Sesterhenn. Joint Pathology Center (JPC), Silver Spring, MD; Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD; Center for Prostate Disease Research (CPDR), Rockville, MD; Saint Lukes Clinic Mountain States, Boise, ID. 124 More Than 10 Needle Biopsy Cores Are Needed for the Presence of Intraductal Carcinoma of the Prostate to Be a Prognostic Factor of Cancer-Specific and Overall Survival in Prostate Cancer Patients with Distant Metastasis (1067) Toyonori Tsuzuki, Masashi Kato, Kyosuke Kimura, Ryo Ishida, Akihiro Hirakawa, Fumie Kinoshita, Naoto Sassa, Akitoshi Fukatsu, Tohru Kimura, Ryohei Hattori, Momokazu Gotoh. Aichi Medical University Hospital, Nagakute, Japan; Nagoya University Hospital, Nagoya, Japan; National Hospital Organization Nagoya Medical Center, Nagoya, Japan; Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan; Komaki City Hospital, Komaki, Japan; Chukyo Hospital, Nagoya, Japan; Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan. 125 Correlation of Prostate Cancer PI-RADS v2 Assessment Categories with Gleason Pattern and Tumor Quantity in Whole Mount Radical Prostatectomy Specimens (940) Michael J Hwang, Jeffrey Weinreb, Peter Humphrey, Jamil Syed, Preston Sprenkle, Angelique Levi. Yale School of Medicine, New Haven, CT. 126 Glucocorticoid Receptor Expression Is Increased in Primary Recurrent Prostate Cancer, Castration Resistant Localized and Metastatic Disease (1061) Maria Tretiakova, Lawrence True, Bruce Montgomery, Mary-Ellen Taplin, Peter S Nelson. University of Washington, Seattle, WA; Harvard Medical School, Boston, MA. GYNECOLOGIC AND OBSTETRIC PATHOLOGY 127 ID4 Allelic Variant Is Associated with Endometriosis and May Affect Mesothelial Epithelial-Mesenchymal Transition (1135) Daniel Dolderer, Colin Bergstrom, Terry Morgan. OHSU, Portland, OR. 128 Expression of Napsin A in Arias Stella Reaction: An Analysis of 40 Cases (1262) Ariel SY Wang, Ka Yu Tse, Oscar GW Wong, Annie NY Cheung, Philip PC Ip. The University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, Hong Kong. 129 Canadian Consensus Guidelines for Benign Endometrial Biopsy Reporting: Development and Internal Validation (1218) Carlos Parra-Herran, Matthew Cesari, Bojana Djordjevic, Katherine Grondin, Mary Kinloch, Martin Koebel, Amrah Pirzada, Anna Plotkin, C Blake Gilks. Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada; Saskatoon City Hospital, Saskatoon, SK, Canada; University of Calgary, Calgary, AB, Canada; Memorial University, St John s, NL, Canada; Trillium Health Partners, Toronto, ON, Canada; Vancouver General Hospital, Vancouver, BC, Canada. 147

208 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Performance of Endometrial Sampling in Diagnosis of Endometrial Carcinoma (1250) Catalin Taraboanta, Heidi Britton, Anna Plotkin, Nazila Azordegan, Philip B Clement, Blake Gilks. University of British Columbia, Vancouver, BC, Canada; University of Toronto, Mississauga, ON, Canada; University of Manitoba, Winnipeg, MB, Canada. 131 The Diagnosis of Mucinous Lesions in Endometrial Samplings by Gynecologic Pathologists: An Interobserver Variability Study (1141) Oluwole Fadare, Andres A Roma, Paulette Mhawech- Fauceglia, Vinita Parkash, Joseph T Rabban. UCSD, San Diego, CA; USC, Los Angeles, CA; Yale, New Haven, CT; UCSF, San Francisco, CA. 132 Endometrial Serous Carcinoma with Pseudo- Endometrioid Features in Biopsies and Curettages: The Diagnostic Value of Focal Apical Anaplastic Nuclei (1142) Oluwole Fadare, Mohamed M Desouki, Andres A Roma, Vinita Parkash, Wenxin Zheng. UCSD, San Diego, CA; Yale, New Haven, CT; Vanderbilt, Nashville, TN; UTSW, Dallas, TX. 133 Insufficient and Scant Endometrial Samples: Determining Pathological Criteria and Consistency in Reporting (1154) Emily Goebel, Meg M McLachlin, Helen Ettler, Michele M Weir. Western University, London, ON, Canada. 139 Clinicopathologic Analysis of MLH1-Hypermethylated Endometrial Carcinomas (1234) Sheila Segura, Robert Soslow, Liying Zhang, Deborah Delair. Memorial Sloan Kettering Cancer Center, New York, NY. 140 Does Universal Tissue Testing Provide Universal Answers? Clinical Challenges Associated with Tumor Screening for Lynch Syndrome Associated Endometrial Cancer (1114) Amanda Bruegl, Molly Daniels, Russell R Broaddus. Oregon Health and Science University, Portland, OR; MDACC, Houston, TX. 141 Implementation of a Universal Endometrial Cancer Lynch Syndrome Screening Program: Lessons Learned (1270) Xuemei Wu, Brittany C Thomas, Jamie N Bakkum- Gamez, Casey L Swanson, Carrie L Langstraat, Myra J Wick, Sarah E Kerr. Mayo Clinic, Rochester, MN. 142 Evaluation of a Universal Mismatch Repair Protein Immunohistochemistry Screening Strategy in Women with Endometrial Carcinoma 60 Years of Age or Younger (1248) Sarah V Strickland, Barbara Norquist, Elizabeth Swisher, Mara H Rendi, Rochelle Garcia, Mark R Kilgore. University of Washington, Seattle, WA. 134 A 20% Solid Architecture Threshold Is Clinically Relevant in Endometrial, Endometrioid Adenocarcinoma (1139) Elizabeth Euscher, Dawen Sui, Anais Malpica. MD Anderson, Houston, TX. 135 Diagnostic Challenges in Mixed Endometrial Carcinomas: Clinical Relevance of Different Neoplastic Components (1277) Gian Franco Zannoni, Tommaso Bizzarro, Frediano Inzani, Damiano Arciuolo, Giovanni Scambia, Esther Rossi. Catholic University, Rome, Italy. 136 Patterns of Recurrences in Grade 1 Endometrioid Endometrial Adenocarcinoma (EEC) (1186) Melissa Krystel-Whittemore, Esther Oliva. Massachusetts General Hospital, Boston, MA. 137 Clinical Outcomes in MLH1-Methylated Endometrial Carcinomas (1119) Sydney Card, Koah Vierkoetter, Teri Longacre. Stanford University Medical Center, Stanford, CA. 138 Clinicopathologic Features of MLH1-Methylated Endometrial Carcinomas (1120) Sydney Card, Koah Vierkoetter, Teri Longacre. Stanford University Medical Center, Stanford, CA. 143 Single Cell Reactivity Is a Distinct Pattern of DNA Mismatch Repair Protein Expression in Endometrial Carcinoma (1175) D Anand Rajan Kanagasabapathy, Ian Hagemann. Carver College of Medicine, University of Iowa Healthcare, Iowa City, IA; Washington University School of Medicine, St Louis, MO. 144 Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrial Adenocarcinoma with Deficient DNA Mismatch Repair (1190) Paul Lee, Eric Duncavage, Samantha McNulty, Jonathan W Heusel, Ian Hagemann. Washington University, St. Louis, MO. 145 p53 Aberrant Endometrial Carcinomas with Loss of Staining for PTEN and/or Mismatch Repair Proteins: A Clinicopathologic Analysis (1188) Nicholas Ladwig, Karuna Garg. University of California San Francisco, San Francisco, CA. 146 PD-L1 Frequently Expressed in Endometrial Carcinoma Associated with Mismatch-Repair Deficiency (1100) Omar Al-Nourhji, Gloria Zhang, Youran Zou, Charles V Biscotti, Peter Rose, Bin Yang. Cleveland Clinic, Cleveland, OH. 148

209 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Endometrial Cancer PD-L1 Expression Is Associated with Mismatch Repair Deficiency, Lymphovascular Invasion and Lymph Node Metastases (1192) Zaibo Li, Amy S Joehlin-Price, Martins Ayoola-Adeola, Karin Miller, Anil Parwani, Floor J Backes, Ashley Felix, Adrian Suarez. The Ohio State University, Columbus, OH; University of California, San Francisco, San Francisco, CA; Johns Hopkins University, Baltimore, MD. 148 PD-L1 Is Expressed in a Significant of Endometrial Carcinomas (1225) Opal L Reddy, Josephine S Aguilar-Jakthong, Itsushi P Shintaku, Neda A Moatamed. David Geffen School of Medicine at UCLA, Los Angeles, CA. 149 Expression of PD-L1 and GHRH-R in Uterine Carcinosarcoma: Potential Markers for Targeted Therapy (1174) Mirka W Jones, Dinesh Pradhan, Agnieszka Onisko, Rohit Bhargava, David J Dabbs. University of Pittsburgh Medical Center, Pittsburgh, PA. 150 Profiling of Tumor Mutational Burden (TMB), Microsatellite Instability (MSI), and PD1/PD-L1 Immunohistochemistry (IHC) in Gynecological Tumors (1138) Julia A Elvin, Michael E Goldberg, Laurie M Gay, John Liao, Alessandro D Santin, James Suh, Jo-Anne Vergilio, Shakti H Ramkissoon, David Fabrizio, Garrett Frampton, Philip Stephens, Jeffrey Ross. Foundation Medicine, Cambridge, MA; Albany Medical College, Albany, NY; Yale University School of Medicine, New Haven, CT; University of Washington School of Medicine, Seattle, WA. 151 TP53 Expression Status and Association with Outcome within Grade 3 Endometrioid Carcinomas of the Endometrium (1184) Martin Kobel, Eshetu G Atenafu, Gregg S Nelson, Marcus Bernardini, Blaise Clarke. University of Calgary, Calgary, AB, Canada; Princess Margaret Cancer Centre, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. 152 Molecular Modifiers of the Immune Microenvironment in Endometrial Endometrioid Adenocarcinoma: PTEN Loss and MMR Deficiency Are Associated with Increased Expression of the Immunosuppressive Signaling Protein STAT6 (1149) Qiong Gan, Suzanne Crumley, Russell R Broaddus. MD Anderson Cancer Center, Houston, TX. 153 Spectrum of PTEN Mutations in Mullerian Malignancies: Impact on PTEN Protein Expression (1130) Suzanne Crumley, Russell R Broaddus. The University of Texas M.D. Anderson Cancer Center, Houston, TX. 154 Differential Expression of SOX17 in Type I and II Endometrial Carcinoma (1236) Maryam Shahi, Mohamed El Hag, Hanqiao Zheng, Mahmoud Khalifa, Faqian Li. University of Minnesota, Minneapolis, MN; University of Pittsburgh Medical Center, Pittsburgh, PA. 155 Yes-Associated Protein-1 (YAP) Is Preferentially Overexpressed in High Grade Endometrial Carcinomas (1228) Brian Robinson, Anthony Martinez, Anne Mills, Cynthia Cohen, Krisztina Z Hanley. Emory University, Atlanta, GA; University of Virginia, School of Medicine, Charlottesville, VA. 156 Loss of 5-Hydroxymethylcytosine (5hmC) Protein Expression in Endometrioid Type Endometrial Carcinoma (1167) Hiba Ibrahim, Karen Dresser, Kristine Cornejo. University of Massachusetts Medical School, Worcester, MA. 157 The Role of Homer Scaffolding Protein 2 (HOMER2) in Endometrial Cancer (1260) Saloni Walia, Kate Lawrenson, Roxanne Manek, Paulette Mhawech-Fauceglia. University of Southern California, Los Angeles, CA; University of Southern California, Los Angeles, LA. 158 Recurrence of Low-Grade Low-Stage Endometrial Cancer Is Associated with Broad Copy Gain and Higher Rates of PIK3CA Mutation (1204) Cathleen E Matrai, Sudeshna Chatterjee-Paer, Andrea Sboner, Juan Miguel Mosquera, Kevin Holcomb, Divya Gupta, Mark A Rubin, Lora Ellenson. Weill Cornell Medicine, New York, NY; Englander Institute for Precision Medicine, New York, NY; Institute for Computational Biomedicine, New York, NY. 159 Comparison of mirna and mrna Expression Profiles in Serous Carcinoma, Clear Cell Carcinoma and Carcinosarcoma of the Endometrium (1195) Sharon X Liang, Victoria Fort, Human Khalili, Ilya Korsunskiy, Andrew Shih, Veena S John, Annette Lee. Northwell Health System, Lake Success, NY; Hofstra Northwell School of Medicine, Manhasset, NY; Feinstein Institute for Medical Research, Manhasset, NY; Northwell Health System, Manhasset, NY. 160 Simplified Immunohistochemical and Targeted Sequencing Approach Reproduces Classification of Endometrial Carcinoma into TCGA Molecular Subgroups (1144) Daniel Fix, Sarah Chiang, Rajmohan Murali, Kay Park, Robert Soslow, Karen Cadoo, Tara E Soumerai, Vicky Makker, Sumit Middha, Carol Aghajanian, Nadeem R Abu-Rustum, Deborah Delair. Memorial Sloan Kettering Cancer Center, New York, NY. 149

210 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Clinicopathological Features of Uterine Neuroendocrine Tumors (NET)s (1265) Adele Wong, Darrell Borger, Esther Oliva. Massachusetts General Hospital, Boston, MA; KK Women s and Children s Hospital, Singapore, Singapore. 162 Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Review of 226 Cases with Emphasis on Patterns of Growth and Immunohistochemical Features (1101) Isabel Alvarado-Cabrero, Raquel Valencia-Cedillo, Emeli Domínguez, Delia Pérez-Montiel. Hospital de Oncología, CMN Siglo XXI IMSS, Mexico City, Mexico; Instituto Nacional de Cancerología, Mexico City, Mexico. 167 Hyalinizing Clear Cell Carcinoma of the Oropharynx and Other Head and Neck Sites Is a p16-positive Tumor: A Potential Pitfall (1291) Justin A Bishop, William H Westra. The Johns Hopkins University, Baltimore, MD. 168 The Value of PRKD1 E710D Sequencing of May- Grünwald-Giemsa Stained Cytology Specimens in Separating Polymorphous Low-Grade Adenocarcinoma from Adenoid Cystic Carcinoma and Pleomorphic Adenoma (1284) Simon Andreasen, Morten Grauslund, Linea C Melchior, Irene Wessel, Katalin Kiss, Tina K Agander. Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Zealand University Hospital, Køge, Denmark. 163 Genomic Characterization of Histologically Distinct Components of Uterine Carcinosarcomas (1152) Felipe Geyer, Kathleen A Burke, Charlotte K Ng, Ronglai Shen, Nicola Fusco, Caterina Marchio, Rajmohan Murali, Robert Soslow, Jorge Reis-Filho, Britta Weigelt. Memorial Sloan Kettering Cancer Center, New York, NY. 164 Patient-Derived Orthoxenografts (PDX) Reproduce Pathological Features of Corresponding Endometrial Carcinomas (EC) (1229) Nuria Ruiz, August Vidal, Jordi Ponce, Lola Marti, Jordi Rovira, Marc Barahona, Josep Maria Piulats, David Llobeta-Navas, Maria Santacana, Alberto Villanueva, Xavier Matias-Guiu. Hospital Universitari de Bellvitge-IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain; Hospital Universitari Arnau de Vilanova, Lleida, Spain; Institut Català d Oncologia-IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain; Business Bioincubator, Bellvitge Health Science Campus, L Hospitalet de Llobregat, Barcelona, Spain. HEAD & NECK PATHOLOGY 165 Mucoacinar Carcinoma: A Rare Intercalated Duct/ Acinar Variant of Mucoepidermoid Carcinoma, Hybrid Tumor, or Distinct Entity? (1294) Manish M Bundele, Ilan Weinreb, Bin Xu, Simion Chiosea, William Faquin, Dora Dias-Santagata, Raja R Seethala. Tan Tock Seng Hospital, SG, Singapore; University of Pittsburgh Medical Centre, Pittsburgh, PA; Massachusetts General Hospital, Boston, MA; University Health Network, Toronto, Canada; Sunnybrook Health Sciences Centre, Toronto, Canada. 166 NKX3.1 Is a Marker of Salivary Duct Carcinoma (SDC) (1336) Gabriel Sica, Cynthia Cohen, Christopher C Griffith. Emory University, Atlanta, GA. 169 Salivary Gland Epithelial Neoplasms in the Pediatric Population: A Single Institute Experience with a Focus on the Histologic Spectrum (1343) Bin Xu, Amandeep Aneja, Ronald Ghossein, Nora Katabi. Memorial Sloan Kettering Cancer Center, New York, NY. 170 Identification of Novel Gene Fusion EWSR1-CREM in Hyalinizing Clear Cell Carcinoma (HCCC) by Anchored Multiplex Polymerase Chain Reaction (1295) Erin Chapman, Angela Goytain, Malcolm Hayes, Wei Xiong, Alena Skalova, Josh Haimes, Brian Kudlow, Cheng-Han Lee, Tony Ng. Vancouver General Hospital, Vancouver, BC, Canada; B.C. Cancer Agency, Vancouver, BC, Canada; St. Paul s Hospital, Vancouver, BC, Canada; Charles University, Pilsen, Czech Republic; ArcherDx, Inc., Boulder, CO; University of British Columbia, Vancouver, BC, Canada. 171 Genomic Profiling of the Two Closely Related cousins Acinic Cell Carcinoma and Mammary Analog Secretory Carcinoma of Salivary Glands Reveals Novel NCOA4-RET Fusion in Mammary Analog Secretory Carcinoma (1298) Snjezana Dogan, Ryma Benayed, Hui Chen, Maria E Arcila, Michael F Berger, Nora Katabi. Memorial Sloan Kettering Cancer Center, New York, NY. 172 Comprehensive Genomic Profiling of Metastatic Salivary Gland Cancer (1331) Jeffrey Ross, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti H Ramkissoon, Kai Wang, Daniel Bowles, Hilary Somerset, Siraj M Ali, Alexa Schrock, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Laurie M Gay. Albany Med Col, Albany, NY; Foundation Med, Cambridge, MA; Univ of Colorado, Denver, CO. 173 Pleomorphic Adenoma: Benign, Recurrent and Malignant Transformation (1289) Munita Bal, Swati Thorat, Swapnil Rane, Asawari Patil, Shubhada Kane, Rajiv Kumar, Gouri Pantavaidya, Jai Prakash Agarwal, Anil D'Cruz. Tata Memorial Centre, Mumbai, Maharashtra, India. 150

211 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall HMGA2 Is a Specific Immunohistochemical Marker for Pleomorphic Adenoma and Carcinoma Ex-Pleomorphic Adenoma (1321) Jeffrey Mito, Vickie Y Jo, Paola Dal Cin, Jeffrey F Krane. Brigham and Women s Hospital, Boston, MA. 175 Expression of Cancer Stem Cell Markers in Salivary Gland Basal Cell Adenocarcinoma and Basal Cell Adenoma (1315) Sook-kyung Kwon, Allyn M Lambertz, Robert Robinson. University of Iowa Hospitals and Clinics, Iowa City, IA; The University of Iowa Carver College of Medicine, Iowa City, IA. 176 Computer Extracted Features of Nuclear Architecture in H&E Sectionsare Predictive of Disease Specific Survival Inoral Cavity Squamous Cell Carcinoma Patients (1316) Cheng Lu, James Lewis, Anant Madabhushi. Case Western Reserve University, Cleveland, OH; Vanderbilt University Medical Center, Nashville, TN. 177 Circulating Cell Free DNA Levels in Oral Squamous Cell Carcinoma (1339) Vandana Tiwari, Sudaiv Nagzarkar, Abhinav A Sonkar, Swati Kumari, Nuzhat Husain. Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; King George s Medical University, Lucknow, Uttar Pradesh, India. 178 EBV-Related Nasopharyngeal Carcinoma in Native Americans of New Mexico (1293) Cory Broehm, Angela Meisner, Marc Barry, Charles Wiggins, Therese Bocklage. University of New Mexico School of Medicine, Albuquerque, NM; University of New Mexico Health Sciences Center, Albuquerque, NM. 179 Expression Pattern of Trk Proteins in Head and Neck Squamous Carcinoma and Its Prognostic Significance (1296) Yoon Ah Cho, Ji Myung Chung, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Sun Och Yoon. Yonsei University College of Medicine, Seoul, Republic of Korea. 182 An Update in the Risk of Lymph Node Metastasis for the Follicular Variant of Papillary Thyroid Carcinoma with the New Diagnostic Paradigm (1337) Aleksandra Sowder, Benjamin L Witt. University of Utah, Salt Lake City, UT. 183 A Novel Approach to Evaluating Frozen Sections for Acute Invasive Fungal Sinusitis (1342) Bartholomew White, Joshua I Warrick, Jaccob Hodos, Max Hennessy, Sakeena Payne, John McGinn, David Goldenberg, Henry Crist. Penn State Hershey Medical Center, Hershey, PA. 184 Extranodal Lymphoid Neoplasms of the Head and Neck: A Retrospective Analysis (1283) Yahya Al-Ghamdi, Faizan Malik, Smita Patel, Brett Mahon, Paolo Gattuso. Rush University Medical Center, Chicago, IL. 185 The Landscape of Genomic and Transcriptomic Alterations in Esthesioneuroblastomas (1312) Jisun Kim, Kathleen A Burke, Rodrigo Gularte-Merida, Felipe Geyer, Fresia Pareja, Britta Weigelt, Fernando Schmitt, Brian P Rubin, Ilan Weinreb, Jorge Reis-Filho. Memorial Sloan Kettering Cancer Center, New York, NY; Laboratoire National de Santé / Luxembourg Anatomie Pathologique, Luxembourg, Luxembourg; Cleveland Clinic, Cleveland, OH; University Health Network, Toronto, Canada. 186 Thirty-Nine Cases of Sinonasal Tract Alveolar Rhabdomyosarcoma in Adults (1338) Lester DR Thompson, Vickie Y Jo, Abbas Agaimy, Antonio Llombart-Bosch, Gema N Morales, Isidro Machado, Markku M Miettinen, Justin A Bishop. SCPMG, Woodland Hills, CA; Brigham & Women s Hosp, Boston, MA; Universitasklinikum Erlangen, Erlangen, Germany; Univ. of Valencia, Valencia, Spain; Inst. de Oncologia, Valencia, Spain; NIH, Bethesda, MD; Johns Hopkins Med Inst., Baltimore, MD. 187 PEComas of the Head and Neck: Diagnostic Challenges of a Rare Tumor with Variable Immunophenotype and Behavior (1304) Abigail L Goodman, Kelly R Magliocca, Christopher C Griffith. Emory University, Atlanta, GA. 180 NIFTP Cases for Reclassification A 10 Year Review and Workload Assessment (1326) Kevin O Hare, Esther O Regan, Aftab Khattak, Marie Louise Healy, Mary Toner. Saint James Hospital, Dublin, Ireland. 181 Gene Expression Profiling by NanoString Discriminates Papillary Carcinoma, Follicular Carcinoma and Normal Thyroid Tissue (1287) Hanan Armanious, Iyare Izevbaye, Benjamin Adam. University of Alberta, Edmonton, AB, Canada. HEMATOPATHOLOGY 188 A 41-Gene Targeted Exon Panel Detects Recurrent Mutations in T Cell Lymphomas (1398) Sebastian Fernandez-Pol, Lisa Ma, Mi Young Kim, Daniel A Arber. Stanford University, Stanford, CA. 151

212 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Differential Expression of Intracellular Signaling Molecules p-erk, MYC, and p-stat3 in Enhancer of Zeste Homolog 2 (EZH2) Protein-Positive T-Cell Neoplasms (1528) Xuejun Tian, Ali Shahsafaei, Ashley Pelton, Christine Unitt, David M Dorfman. Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; Brigham and Women s Hospital, Harvard Medical School, Boston, MA. 196 Clinicopathologic Analysis of HIV-Associated Anaplastic Large Cell Lymphomas (ALCL), ALK- Negative (1464) Anna Nam, Susan Mathew, Paul Rubinstein, Yi- Hua Chen, Swarna Gogineni, Kelly Petrowski, Amy Chadburn. Weill Cornell Medical College, New York, NY; Northwestern Medicine, Chicago, IL; Stroger Hospital of Cook Count, Chicago, IL. 190 Evaluation of CD38 Expression in T-cell Lymphoproliferative Disorders (1413) Michelle L Grant, John H Lunde, Katherine A Devitt, Juli-Anne Gardner. University of Vermont Medical Center, Burlington, VT. 191 PD-L1 Expression in T and NK-cell Lymphomas: A New Therapeutic Target (1351) Joshua Anderson, Linlin Wang. University of California, San Francisco, CA. 192 Detection and Diagnostic Utility of T-Cell Receptor Delta Chain in Lymphoid Neoplasms (1368) Alexander Chan, Achim Jungbluth, Janine Pichardo, Mikhail Roshal, Melissa Pulitzer, Ahmet Dogan. Memorial Sloan Kettering Cancer Center, New York, NY. 193 The Pattern of Diminished Surface CD3 Expression on Peripheral T-cell Lymphomas Is a Consistent Marker of Malignancy and Indicative of Certain Subtypes (1420) Jenny C Hoffmann, Robert Ohgami. Stanford University Medical Center, Stanford, CA. 194 Functional Interactions of ALK+ Anaplastic Large Cell Lymphoma (ALCL)-Derived Exosomes with Tumor Microenvironment (1492) George Rassidakis, Dimitrios Chioureas, Janina Beck, George E Baltatzis, Pedro Fonseca, Nikolaos Tsesmetzis, Ioulia Vardaki, Vasiliki Leventaki, Elias Drakos, Theocharis Panaretakis. Karolinska Institutet, Stockholm, Sweden; National and Kapodistrian University of Athens, Athens, Greece; St Jude Children s Research Hospital, Memphis, TN; University of Crete Medical School, Heraklion Crete, Greece. 195 PD-L1 Is Commonly Expressed and Transcriptionally Regulated by STAT3 and MYC in ALK-Negative Anaplastic Large Cell Lymphoma (1354) Vasillios Atsaves, Nikolaos Tsesmetzis, Dimitrios Chioureas, Lorand Kis, Vasiliki Leventaki, Elias Drakos, Theocharis Panaretakis, L Jeffrey Medeiros, George Rassidakis. Karolinska Institutet, Stockholm, Sweden; St Jude Children s Research Hospital, Memphis, TN; The University of Texas M.D. Anderson Cancer Center, Houston, TX; University of Crete Medical School, Heraklion Crete, Greece. 197 IL-13 Is Produced by Tumor Cells in Breast Implant Associated Anaplastic Lymphoma (BI-ALCL): Implications for Pathogenesis (1428) Marshall Kadin, Mark W Clemens, L J Medeiros, Roberto N Miranda. Roger Williams Medical Center, Providence, RI; The University of Texas MD Anderson Cancer Center, Houston, TX. 198 Evaluation of Flow Cytometric Variables in Mycosis Fungoides Blood Staging (1426) Mohsin Jamal, Ron Brown, Kedar V Inamdar, Juan Gomez-Gelvez, John L Carey, Madhu P Menon. Henry Ford Hospital, Detroit, MI. 199 High Throughput Sequencing to Assess Clonality in Cutaneous T-cell Lymphoproliferations Including Cutaneous T-cell Lymphoma Across a Range of Histologic Categories (1493) Bryan Rea, Paul Haun, Ryan Emerson, Marissa Vignali, Midhat Farooqi, Sara Samimi, Rosalie Elenitsas, Alain Rook, Ilan Kirsch, Adam Bagg. University of Pennsylvania, Philadelphia, PA; Adaptive Biotechnologies, Seattle, WA. 200 Comparison of TCL1 Overexpression and TCL1 Gene Rearrangement in Patients with T- Cell Prolymphocytic Leukemia (1521) Yi Sun, Guilin Tang, Zhihong Hu, L J Medeiros, Sa Wang. MDACC, Houston, TX. 201 Genetic Characterization of Indolent T-cell Lymphoproliferative Disorders of the Gastrointestinal Tract (1478) Nupam Patel, Bachir Alobeid, Mahesh M Mansukhani, Govind Bhagat. Columbia University Medical Center, New York, NY. 202 The Immunophenotypic Spectrum of Reactive gammadelta T-cells by Multiparameter Flow Cytometry: An Attempt to Avoid Erroneous Diagnoses (1366) Eugene Carneal, Robert Ohgami. Stanford University, Stanford, CA. 203 The Utility of Molecular KIR Phenotyping in Large Granular Lymphocytic Leukemia (1467) Jadee Neff, Alejandro Ferrer, Dragan Jevremovic, William G Morice, Adam Schrum, Min Shi. Mayo Clinic, Rochester, MN. 152

213 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Spectrum of B Cell Lymphomas in T Cell Large Granular Lymphocytic Leukemia(T-LGL) Includes Diffuse Large B Cell Lymphoma (1411) Tanu Goyal, Eric D Hsi. Cleveland Clinic Foundation, Cleveland, OH. 205 Bone Marrow Features in Patients with Germline Mutations in CTLA4 Overlap with Aplastic Anemia and LGL Leukemia (1535) Laura Wake, Weixin Wang, Koneti Rao, Gulbu Uzel, Katherine R Calvo. NIH, Bethesda, MD; NIAID, Bethesda, MD. 206 High Proliferative Index in Acquired Aplastic Anemia (AAA) Bone Marrow Does Not Predict Progression to Myelodysplastic Syndromes (MDS) (1450) Raquel Marchesi, Elvira Velloso, Marlene Garanito, Sheila Siqueira, Raymundo Azevedo Neto, Cristina Kumeda, Maria Claudia Zerbini. Clinical Hospital of São Paulo Medical School, São Paulo, Brazil. 207 Morphological, Immunohistochemical and Cytogenetic Bone Marrow Characterization of 12 Patients with Acquired Aplastic Anemia (AAA) That Progressed to Myelodysplastic Syndromes (MDS) (1451) Raquel Marchesi, Elvira Velloso, Marlene Garanito, Sheila Siqueira, Raymundo Azevedo Neto, Cristina Kumeda, Maria Claudia Zerbini. Clinical Hospital of São Paulo Medical School, São Paulo, Brazil. 208 Cytogenetic and Molecular Features of 59 Cases of Bone Marrow Failure Syndrome (1553) Xiaohui Zhang, Afshan Idrees, Lynh Nguyen, Jeffrey E Lancet, Lynn Moscinski, Ling Zhang. H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL. 209 Immunophenotypic Abnormalities Highly Suggestive of Paroxysmal Nocturnal Hemoglobinuria (PNH) Can Be Detected with Routine Flow Cytometric Analysis of Bone Marrow (BM) (1389) Alina Dulau Florea, Neal S Young, Irina Maric, Elaine K Jordan, Chunjie Jiang, Farhan Ahmad, Raul Braylan. NIH, Bethesda, MD. 210 Spectrum of Bone Marrow Pathology in Patients with Germline Mutations in CECR1 (1358) Jayalakshmi P Balakrishna, Amy Hsu, Amanda Ombrello, Weixin Wang, Steven M Holland, Dennis D Hickstein, Daniel L Kastner, Ivona Aksentijevich, Katherine R Calvo. NIH/CC/DLM, Bethesda, MD; NIH/NIAID, Bethesda, MD; NIH/NCI, Bethesda, MD; NIH/NHGRI, Bethesda, MD. 211 Antigen Specificity of the Monoclonal IgM Antibody in Schnitzler Syndrome (1474) Lais Osmani, Patrizio Caturegli. The Johns Hopkins School of Medicine, Baltimore, MD. 212 What Is the Significance of Positive TP53 Immunohistochemistry in Bone Marrows with Reactive Cytopenia? Correlation with TP53 Mutation by Next Generation Sequencing and Comparison with Low Risk Myelodysplastic Syndromes (1466) Mehdi Nassiri, Vinushree Swamy, Cecilia Ramirez- Santrich, Magdalena Czader. Indiana Univeristy School of Medicine, Indianapolis, IN. 213 Tissue Based Chimerism Analysis Enhances Detection of Donor Derived Neoplasia in Allogeneic Stem Cell Transplant Patients (1359) Ezra Baraban, Shimin Hu, Pei Hui, Dennis Cooper, Nikolai Podoltsev, Mina Xu. Yale, New Haven, CT; MD Anderson Cancer Center, Houston, TX; Rutgers, New Brunswick, NJ. 214 Lymphoid Proliferations Following Umbilical Cord Stem Cell Transplant (1381) Rory Crotty, Olga Pozdnyakova, Yi-Bin Chen, Karen Ballen, Robert P Hasserjian. Massachusetts General Hospital, Boston, MA; Brigham and Women s Hospital, Boston, MA. 215 Cancer Therapy-Related Lymphoproliferative Disorders in Patients Who Have Not Received Immunomodulator Agents or Stem Cell Transplantation. Clinicopathologic Analysis of 14 Cases (1485) Sergio Pina-Oviedo, L Jeffrey Medeiros. M.D. Anderson Cancer Center, Houston, TX. 216 Mast Cell Leukemia (MCL); Clinicopathologic Features of a Rare Disease (1384) Simone Davion, Sa Wang, Oscar Silva, Sam Sadigh, Daniel A Arber, Adam Bagg, Jason Gotlib, Tracy George. University of New Mexico, Albuquerque, NM; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Stanford University, Stanford, CA; University of Pennsylvania, Philadelphia, PA. 217 Recurrent KRAS and MAP2K1 Mutations Detected in Rosai-Dorfman Disease by Next-Generation Sequencing (1402) Sofia Garces, L Jeffrey Medeiros, Keyur P Patel, Shaoying Li, Sergio Pina-Oviedo, Jingyi Li, Joseph Khoury, Cameron Yin. The University of Texas MD Anderson Cancer Center, Houston, TX. 218 Cyclin D1 Identifies Neoplastic Langerhans Cells (1509) Vignesh Shanmugam, Jeffrey W Craig, Elizabeth A Morgan, Jason L Hornick, Olga Pozdnyakova. Brigham and Women s Hospital, Boston, MA. 219 Dendritic Cell Sarcoma vs Inflammatory Pseudotumor: Phenotypic and Molecular Characterization (1348) Iban Aldecoa, Gerard Frigola, Alba Navarro, Adriana Sierra, Jorge de la Oliva, Carla Montironi, Blanca Gonzalez-Farre, Antonio Martínez-Pozo, Luis Colomo, Elias Campo, Olga Balagué. Hospital Clinic University of Barcelona, Barcelona, Spain; Hospital del Mar, Barcelona, Spain. 153

214 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall The Significance of the Morphologic Finding of Hemophagocytosis in Bone Marrow Specimens Involved, and Not Involved by Hemophagocytic Lymphohistiocytosis (1404) Eric Gars, Robert Ohgami. Stanford University, Stanford, CA. 229 Immune Profile of Ciliated Muconodular Papillary Tumors (2001) Emiko Udo, Sayuri Nakamura, Mikiko Hashisako, Junya Fukuoka. Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. 221 Immunophenotypic Differentiation Pattern of Eosinopoiesis in Human Bone Marrow: A New Flow Cytometric Tool for Studying Eosinophil Maturation (1530) Christopher J Trindade, Jamie Hahn, Sachein Sharma, Dragan Maric, Irina Maric. NIH, Bethesda, MD. 222 Clinical Significance of Green Inclusions in Neutrophils and Monocytes (1395) Alaleh Esmaeili Shandiz, Diana M Haninger, George Girgis, Jiehao Zhou. Indiana University School of Medicine, Indianapolis, IN. 223 Evaluation of High Resolution Static Images by Telepathology Is Adequate for Rapid Interpretation of Peripheral Blood Smears (1371) Rong Chen, Katsiaryna Laziuk, Richard D Hammer. University of Missouri, Columbia, MO. 224 Immunohistochemical Analysis of Endothelial Cells in Vascular Transformation of Lymph Node Sinuses: Vascular or Lymphatic Differentiation? (1360) Basma Basha, Eric D Hsi. The Cleveland Clinic, Cleveland, OH. 225 Increased Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) A Potential Biomarker for Tumor Angiogenesis and Metastasis (1383) Ananya Datta-Mitra, Hong Qui, Tatsuya Sawamura, Ralph Green, Mingyi Chen. University of California, Davis, Sacramento, CA; Shinshu University School of Medicine, Matsumoto, Japan. 226 Hemorrhagic Complication and Its Laboratory Evaluation in Patients Receiving Direct Oral Anticoagulants (1548) Ming Xie, Subhash Edupuganti, Catherine Xie, Mary Wyrzykowski, Elizabeth Wey. Beaumont Hospital, Troy, MI. 227 The Effects of Rivaroxaban on Activated Protein C Resistance and Protein S Testing (1454) Elena Maryamchik, Elizabeth M Van Cott. Massachusetts General Hospital, Boston, MA. PULMONARY PATHOLOGY 230 Metastatic Basal Cell Carcinomas to Thorax and Bone: A Clinicopathological and Immunohistochemical Study of 14 Cases (2006) Annikka Weissferdt, Neda Kalhor, Cesar Moran. MD Anderson Cancer Center, Houston, TX. 231 Radiological and Histopathogical Features of Benign and Malignant Lung Nodules (1906) Jason L Cheng, Eric Hart, Malcolm Decamp, Rishi Raj, Kirtee Raparia. Northwestern University, Chicago, IL. 232 Aerogenous Intrapulmonary Metastasis of Lung Adenocarcinomas: Pathologic and Radiologic Features and Correlation (1904) Nina Chang, Joao R Inacio, Carolina A Souza, Chi K Lai, Harman S Sekhon, Marcio M Gomes. The Ottawa Hospital, Ottawa, ON, Canada. 233 The Role of SATB2 and TCTE3 as Diagnostic Markers for CDX-2 Positive/TTF-1 Negative Primary Mucinous Adenocarcinomas of the Lung (1917) Liz Edmund, Shaolei Lu, Madhu Ouseph, Kara A Lombardo, Dongfang Yang, Maria L Garcia-Moliner, Bassam Aswad, Li Juan Wang. Brown University, Providence, RI. 234 SATB2 Expression in Adenocarcinoma of the Lung with and without Enteric Differentiation (1948) Austin McCuiston, Daniel L Miller, Qing K Li, Ed Gabrielson, Peter Illei. Johns Hopkins Medical Institution, Baltimore, MD. 235 Central versus Peripheral Carcinoid Tumors of the Lung (1961) Daisuke Nonaka, George Papaxoinis, Wasat Mansoor. The Christie Hospital, Manchester, United Kingdom; The University of Manchester, Manchester, United Kingdom. 236 Metastatic Lung Carcinoid Tumors: Evidence of Proliferation Rate Progression at Metastatic Sites (1911) Patrice Desmeules, Joshua K Sabari, Maria Laureana Santos-Zabala, Anna M Litvak, Maria C Pietanza, John T Poirier, Charles M Rudin, David S Klimstra, William Travis, Natasha Rekhtman. Memorial Sloan Kettering Cancer Center, New York, NY. 228 Aberrant mtor Pathway Signaling Associated with Sclerosing Pneumocytoma (2010) Eunhee S Yi, Hee Eun Lee, Emily G Barr Fritcher, Jesse S Voss, Benjamin Kipp. Mayo Clinic, Rochester, MN. 154

215 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Comparative Molecular Analysis of Typical and Atypical Pulmonary Carcinoid Tumors by Next Generation RNA Sequencing (1987) Olga Sazonova, Babak Khoshkrood-Mansoori, Andréanne Gagné, Michèle Orain, Yohan Bossé, Philippe Joubert, Joël Tremblay Joël Tremblay Marchand. University Laval, Quebec, QC, Canada; Quebec Heart and Lung Institute, Quebec, QC, Canada. 238 Correlation Between MET Gene Copy and Molecular Profiling in Non-Small Cell Lung Cancer (1922) Lianghua Fang, Hui Chen, L Jeffrey Medeiros, Shimin Hu, Lin Pei, Raja Luthra, Rajesh R Singh, Mark J Routbort, David Hong, Xinyan Lu. The University of Texas MD Anderson Cancer Center, Houston, TX; Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China; Feinberg School of Medicine Northwestern University, Chicago, IL. 239 In Situ Detection of MET Exon 14 Skipping in Lung Carcinoma via a Highly Sensitive BaseScope In-Situ Assay in FFPE Tissues (1941) Jeff Kim, Xiao-Ming Mindy Wang, Nan Su, Rob Monroe, Xiao-Jun Ma, Hans-Ulrich Schildhaus, Emily Park. Advanced Cell Diagnostics, Newark, CA; University Hospital Goettingen, Göttingen, Germany. 240 Ligation Dependant-RTPCR: A New Specific and Low Cost Technique to Detect ALK, ROS and RET Rearrangements in Lung Adenocarcinoma (1973) Nicolas Piton, Claire Gravet, Philippe Ruminy, Vinciane Marchand, Elodie Colasse, Luc Thiberville, Fabrice Jardin, Jean-Christophe Sabourin. Rouen University Hospital, Rouen, France; Centre Henri Becquerel, Rouen, France. 241 Characterization and Correlation of ALK Fusion Breakpoints in ALK FISH Rearranged Non-Small Cell Lung Cancer by Anchored Multiplex PCR and Next- Generation Sequencing (1960) Catherine Nicka, Francine B de Abreu, Jason D Peterson, Gregory J Tsongalis, Laura Tafe. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 242 Detecting ALK, ROS1 and RET Gene Translocations in Non-Small Cell Lung Cancer (NSCLC) with the NanoString Platform (2005) Hangjun Wang, Anke F Rijk, Zari Dastani, Jason Agulnik, Victor Cohen, David Small, Carmela Pepe, Lama Sakr, Goulnar Kasymjanova, Anna Y Wang, Alan Spatz, Leon C van Kempen. Jewish General Hospital, McGill University, Montreal, QC, Canada. 243 PDL-1 Expression in Synchronous Lung Nodules: Association with Driver Mutations and CD8+ Cytotoxic T Lymphocytes (1963) Zehra Ordulu, Marina Kem, Tiffany Huynh, Dora Dias- Santagata, John Iafrate, Mari Mino-Kenudson. Massachusetts General Hospital, Boston, MA. 244 Discordant PD-L1 Expression in Non-Small Cell Lung Carcinoma Tissue Microarray Cores Compared to Corresponding Whole Tissue Sections (1912) Brandon Driver, Ross A Miller, Michael Deavers, Eric Bernicker, Philip T Cagle. Houston Methodist Hospital, Houston, TX. 245 Intratumoral Heterogeneity of Programmed Cell Death Ligand-1 (PD-L1) Expression in Lung Cancers Assessment by Spiral Array (1958) Sayuri Nakamura, Kentaro Hayashi, Yuki Imaoka, Yuka Kitamura, Yuko Akazawa, Ruben Groen, Takeshi Nagayasu, Naoya Yamasaki, Tomoshi Tuchiya, Junya Fukuoka. Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. 246 Comparative Immunohistochemical Analysis of Programmed Death-Ligand 1 (PD-L1) Utilizing 22C3 and 28.8 Clones for Targeted Drug Therapy in Primary and Metastatic Tumor Resections (1898) Fatimah I Alruwaii, Weihua Song, Howard Wu, Muhammad Idrees. Indiana University School of Medicine, Indianapolis, IN. 247 Non-Mesothelial Neoplasms in Individuals with Malignant Mesothelioma (1901) Kelly Butnor, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli. University of Vermont Medical Center, Burlington, VT; Duke University Medical Center, Durham, NC. 248 FISH Analysis of Crizotinib Target Genes MET/ALK/ ROS-1 in Malignant Mesothelioma (1923) Franco Fedeli, Sandra Salvi, Simona Boccardo, Serena Varesano, Paolo Dessanti, Alessandro Valentino, Paola Ferro, Pier Aldo Canessa, Jean Louis Ravetti, Maria Pia Pistillo, Silvio Roncella. Azienda Sanitaria Locale n 5 Spezzino, La Spezia, Italy; IRCCS AOU San Martino-IST, Genova, Italy. 249 Whole Exome Sequencing Identifies Unique Gene Mutations and Copy Losses in Calcifying Fibrous Tumor of the Pleura (1949) Mitra Mehrad, William A LaFramboise, Humberto Trejo Bittar, Samuel A Yousem. Vanderbilt University Medical Center, Nashville, TN; University of Pittsburgh Medical Center, Pittsburgh, PA. 250 Genomic Profiling of Sarcomatoid and Biphasic Malignant Pleural Mesotheliomas Using Targeted Next Generation Sequencing (1930) Albert Huho, Khalil Sheibani, Patrick Leach, Kassandra Jiron, Robert Ramos, Gwyneth Olson, Mohammad Vasef. University of New Mexico, Albuquerque, NM; Western Pathology Consultation, Tustin, CA. 155

216 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Poorly-Differentiated Non-Keratinizing Squamous Cell Thymic Carcinoma: A Clinicopathologic, Immunohistochemical and Molecular Genetic Study of 25 Cases (1997) David Suster, Alexander C Mackinnon, German Pihan, Saul Suster. Beth Israel Deaconess Medical Center, Boston, MA; Medical College of Wisconsin, Milwaukee, WI. 252 Thymic Carcinoma Histology and Prognosis- A Single- Center Review (1978) Rachel E Rominger, Michael A Balatico, Yesim Gokmen-Polar, Sunil Badve. Indiana University, Indianapolis, IN. 253 Pathologic Patterns of Inflammatory Lung Injury Following Anti-PD-1 Immunotherapy in Asymptomatic Patients (2003) Moises J Velez, Charles Leduc, Matthew Hellmann, Jamie Chaft, Jarushka Naidoo, Janis M Taube, Patrick M Forde, Valerie Rusch, William Travis, Natasha Rekhtman. Memorial Sloan Kettering Cancer Center, New York, NY; The Johns Hopkins University, Baltimore, MD. 254 Increased IgG4 Density and IgG4:IgG Ratios in Interstitial Lung Disease Are Associated with Rheumatologic Diseases and Usual Interstitial Pneumonia (2015) Yang Zhang, Allen P Burke, Nevins W Todd. University of Maryland Medical Center, Baltimore, MD. 255 The Proposal of User-Friendly Formula to Separate CTD-IPs and IIPs (1909) Mutsumi Dairiki, Mikiko Hashisako, Shuntaro Sato, Kensuke Kataoka, Yasuhiro Kondoh, Hiroyuki Taniguchi, Hiromi Ichikawa, Junya Fukuoka. Nagasaki University Hospital, Nagasaki, Japan; Tosei General Hospital, Seto, Aichi, Japan. 256 Noninfectious Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation: A Spectrum of Histopathological Patterns (1950) Véronique Meignin, Françoise Thivolet-Bejui, Marianne Kambouchner, Claire Hussenet, Claire Danel, Anne Bergeron. Hôpital Saint Louis, Paris, France; Hospices Civils, Lyon, France; Hôpital Avicenne, Bobigny, France; Hôpital Bichat, Paris, France. 257 Isolated Small Airways Inflammation in Lung Allograft Transbronchial Biopsies Is More Often Associated with Increased B-Cells and Concurrent Infection (1929) Ying-Han R Hsu, Marie-Christine Aubry, Sarah Jenkins, John P Scott, Anja C Roden. Mayo Clinic, Rochester, MN. QUALITY ASSURANCE 258 Checklist Implementation for Intraoperative Consultations: Improved Quality and Safety (2019) Kevin Anderson, Jia Xu, Yigu Chen, Jeffrey D Goldsmith, Yael K Heher. Beth Israel Deaconess Medical Center, Boston, MA; Boston Children s Hospital, Boston, MA. 259 Critical Communication Between Pathologists and Surgeons During Intraoperative Consultations: Direct Face-to-Face Interaction (2065) Timothy M McDonald, Beverly Y Wang, Thomas K Lee. University of California Irvine Medical Center, Irvine, CA. 260 Diagnostic Accuracy of Intraoperative Frozen Section Diagnosis: A Retrospective Review of 11,860 Frozen Sections (2073) Ami Patel, Francesca Khani, Brian Robinson, Theresa Scognamiglio. Pathology and Laboratory Medicine, New York, NY. 261 A Comparison of Freeze Artifact Using Three Frozen Section Techniques (2082) Nida Safdar, Melissa Straub, Christopher Bantz, Kathleen Montgomery, Hernan Correa, Emily Reisenbichler. Vanderbilt University, Nashville, TN. 262 Dual-Purpose Biopsy Container and Tissue Processing Cassette (2031) Marjorie P David, Shawn LeDoux. University of Arkansas for Medical Sciences, Little Rock, AR. 263 Comparison of Immunohistochemistry Staining Performed on Cell Blocks versus Surgical Blocks from the Same Tumor (2095) Sharlin Varghese, Amanda K Martin, Donna Russell, Loralee McMahon, Julietta Fiscella. University of Rochester Medical Center, Rochester, NY. 264 New Benchmark Data from College of American Pathologists for Immunohistochemical Assay Validation (2069) Raouf E Nakhleh, Lauren N Stuart, Keith E Volmar, Jan A Nowak, Lisa A Fatheree, Rhona J Souers, Patrick L Fitzgibbons, Jeffrey D Goldsmith, J R Astles. Mayo Clinic Jacksonville, Jacksonville, FL; Emory University, Atlanta, GA; Roswell Park Cancer Institute, Buffalo, NY; College of American Pathologists, Northfield, IL; St. Jude Medical Center, Fullerton, CA; Children s Hospital Boston and Harvard Medical School, Boston, MA; Centers for Disease Control and Prevention, Atlanta, GA; UNC REX Healthcare, Raleigh, NC. 156

217 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Impact of College of American Pathologists Evidence- Based Guideline on Immunohistochemistry Assay Validation Practices (2068) Raouf E Nakhleh, Jeffrey D Goldsmith, Rhona J Souers, Lisa A Fatheree, Keith E Volmar, Lauren N Stuart, Jan A Nowak, J R Astles, Patrick L Fitzgibbons. Mayo Clinic Jacksonville, Jacksonville, FL; Childrens Hospital Boston and Harvard Medical School, Boston, MA; College of American Pathologists, Northfield, IL; UNC Rex Healthcare, Raleigh, NC; Emory University, Atlanta, GA; Roswell Park Cancer Institute, Buffalo, NY; Centers for Disease Control and Prevention, Atlanta, GA; St. Jude Medical Center, Fullerton, CA. 266 Modeling of Effectiveness of Addition of New Antibodies in Panel Immunohistohistochemistry (2041) Erin Garrett, Amin Mohammad, Clare McCormick-Baw, Riyam Zreik, Arundhati Rao. Baylor Scott and White, Temple, TX. 267 Inter-Observer Reproducibility in PD-L1 Immunohistochemistry Interpretation Improves with Training (2084) Jennifer L Sauter, Rondell Graham, Michael S Torbenson, Thomas J Flotte, Joseph J Maleszewski, Anja C Roden, Heidi Lehrke, Michael G Keeney, Sarah Jenkins, Sarah E Kerr. Mayo Clinic, Rochester, MN. 268 Immunohistochemical Detection of Cytomegalovirus Particles in Patients with Suspected CMV Colitis: The Effect of Chromogen Method on Diagnostic Accuracy (2076) Regina M Plummer, Archana Bhaskaran, Tetyana N Mettler, Khalid Amin, Paari Murugan. University of Minnesota, Minneapolis, MN. 269 Effect of Discontinuing Reflex Testing for Helicobacter Pylori by Immunohistochemistry (2098) Christopher Vytlacil, Jan F Silverman. Allegheny General Hospital, Pittsburgh, PA. 270 Establishment of Helicobacter Pylori Detection Protocol in Patients Undergoing Laparoscopic Sleeve Gastrectomy (2074) Priyanka Patil, Qiang Liu, Ashwin Akki, Yanan Fang. Albert Einstein College of Medicine / Montefiore Medical Center, Bronx, NY. 271 Analysis Four-Years into a Universal Lynch Syndrome Screening Program Highlights Challenges and Opportunities (2023) Andrew M Bellizzi, Amelia Fierro-Fine, Anthony Snow. University of Iowa, Iowa City, IA. 272 Evaluation of Mismatch Repair Immunohistochemistry Followed by Microsatellite Instability Testing in Colorectal Carcinoma (2088) Anthony Snow, Amelia Fierro-Fine, Andrew M Bellizzi. University of Iowa Hospitals and Clinics, Iowa City, IA. 273 An Anorectal Cytology Quality Assurance Study of 43 Patients with Anal High-Grade Squamous Intraepithelial Lesions (2087) Theresa Smith, Sarah Jamshed, Xiaofei Wang. UMass Memorial Medical Center, Worcester, MA. 274 Initial Experience with an Internal Review Process for Achieving Consensus Diagnosis of Atypical Barrett s Esophagus Biopsies within a Large Multi-Hospital Pathology Practice (2033) Jon Davison, Reetesh Pai. University of Pittsburgh School of Medicine, Pittsburgh, PA. 275 Clinical Impact of Pediatric Gastrointestinal Endoscopy (2051) Satoru Kudose, Aarti Sharma, David Rudnick, ILKe Nalbantoglu. Washington University in St. Louis, St. Louis, MO. 276 The Spectrum of Histopathological Findings in Patients Undergoing Colonoscopy for Chronic Diarrhea (2058) Yongjun Liu, Setareh Sharzehi, Negar Rassaei. Penn State Hershey Medical Center, Hershey, PA. 277 Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder (2016) Ashwin Akki, Qiang Liu, Sun M Chung, Kathryn E Tanaka, Nicole C Panarelli. Montefiore Medical Center, Bronx, NY. 278 Integration of Whole Slide Digital Imaging (WSDI) for Primary Diagnosis: A Validation of Its Utility in Gastrointestinal Pathology Biopsy Workflow at a Multi- Center Academic Institution (2056) Su-Yang Liu, Gregory E Lauwers, Grace E Kim, Zoltan Laszik. University of California, San Francisco, San Francisco, CA. 279 Accurate Assessment of Tumor Size in Breast Cancer Patients: Comparison of Different Radiological Modalities with Final Pathology (2038) Carolina Dominguez, Yin Xiong, Laila Khazai, Marilin Rosa, Emmanuel Agosto-Arroyo. Moffitt Cancer Center, Tampa, FL. 280 Analysis of Diagnostic Breast Biopsies with Atypical Ductal Proliferation: A Quality Assurance Measure (2094) Marta Van Straten, Toshi Ghosh, Daniel W Visscher, Sejal Shah. Mayo Clinic, Rochester, MN. 281 Excision Biopsy Diagnosis of Patients with Breast Core Needle Biopsy Findings Reported as Atypical Intraductal Epithelial Proliferations (2035) Vanessa Grace M De Villa, Bruce Youngson, Naomi Miller, David McCready, Arthy Saravanan, Tanvi Jakhi, Christine Wilson, Supriya Kulkani, Susan J Done. University Health Network and University of Toronto, Toronto, ON, Canada. 157

218 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Immunohistochemical Evaluation of Sentinel Lymph Nodes in Breast Cancer (2057) Yongjun Liu, Dani S Zander, Dipti M Karamchandani. Penn State Hershey Medical Center, Hershey, PA. 283 One H&E Stain Is Sufficient for Evaluation of Sentinel Lymph Nodes in Breast Cancer (2030) Agata Czapla, Helena Hwang. UT Southwestern Medical Center, Dallas, TX. 284 Histopathologic Discordance Between Tumor Grade and Hormone Receptor/HER2 Status in Breast Cancer: An Institutional Experience (2061) Malary Mani, Abul Ala Syed Rifat Mannan, Wen Fan. Mount Sinai Health System, New York, NY. 285 Practice of HER2 Testing in Invasive Breast Cancer: A Single Center Experience (2062) Malary Mani, Abul Ala Syed Rifat Mannan, Wen Fan. Mount Sinai Health System, New York, NY. 286 A Practical Quality Control Procedure for Decalcified Bone Specimens in Evaluation of ER/PR/HER-2 Immunohistochemistry (2046) Vivian M Hathuc, Ellen East, Judy Pang, Julie M Jorns, Rajan Dewar. University of Michigan Health System, Ann Arbor, MI. 287 Breast Carcinoma Biomarkers: Effects of Hydrochloric Acid and Formic Acid Decalcification on Immunohistochemistry and In Situ Hybridization (2103) Jennifer Yoest, Beth Z Clark, Agnieszka Onisko, David J Dabbs. UPMC, Pittsburgh, PA. 288 Robotic and Semi-Automated Microtomy Can Decrease Variability in HER2 Staining Intensity (2026) Elizabeth Chlipala, Scott Crawford, Joshua Johnson, Kevin Chu, Alyicia Rios, Farah Patell-Socha, Karen Copeland, Allen M Gown, Regan Fulton. Premier Laboratory, Longmont, CO; Array Science, Sausalito, CA; Sakura Finetek, Torrance, CA; Horizon Discovery, Cambridge, United Kingdom; Boulder Statistics, Boulder, CO; PhenoPath, Seattle, WA. 289 Prospective Testing for Her2 Using Simultaneous Immunohistochemistry (IHC) and Chromogenic In Situ Hybridization (CISH) (2034) Javier De Luca-Johnson, Britni RE Bryant, Jeannette Mitchell, Valerie Cortright, Donald L Weaver, Andrew Goodwin, Maureen Harmon, Abiy Ambaye. University of Vermont College of Medicine, Burlington, VT. 290 HER2/ERBB2 Testing in Breast Carcinoma by Next Generation Sequencing (2101) Adele Wong, Atul Bhan, Jochen K Lennerz, Elena Brachtel. Massachusetts General Hospital and Harvard Medical School, Boston, MA. 291 Impact of Consensus Conference Review on Diagnostic Disagreements in the Evaluation of Cervical Biopsies (2053) Lester Layfield, Richard D Hammer, Shellaine R Frazier, Magda Esebua, William W Bivin, Katsiaryna Laziuk, Van T Nguyen, Eric Johannesen, Robert L Schmidt. University of Missouri, Columbia, MO; University of Utah and ARUP Laboratories, Salt Lake City, UT. 292 Value of Ultrastaging via Additional Sections and Cytokeratin Immunostain for Sentinel Lymph Node Evaluation in Gynecologic Malignancies (2044) Min Han, Hannah Krigman, Andrea R Hagemann, Ian Hagemann. Washington University, St. Louis, MO. 293 Incidental Prostate Cancer in Cystoprostatectomy Specimens, a Clinical Effectiveness and Quality Improvement Study (2097) Angela Viaene, Lauren E Schwartz. Hospital of the University of Pennsylvania, Philadelphia, PA. TECHNIQUES (INCLUDING ULTRASTRUCTURE) 294 Comparison of PD-L1 Immunostain Concordance of SP263 and SP142 Across Different Tumor Types (2140) Manando Nakasaki, Oluwole Fadare, Sandip Patel, Donna Hansel. University of California at San Diego, La Jolla, CA. 295 PD-L1 Expression in Male Breast Carcinoma: Comparison of RNA In Situ Hybridization Technology vs Immunohistochemistry (2110) Anand C Annan, Momin T Siddiqui, Sonal Bhimji- Pattni, Cynthia Cohen. Emory University School of Medicine, Atlanta, GA. 296 Pathologists Accuracy and Reproducibility Rates for PD-L1 Immune Cell Quantitation Using a Digital Pathology Image Analysis Algorithm in Urothelial Carcinoma Samples (2114) Michael Barnes, Isaac Bai, Kien Nguyen, Joerg Bredno, Rachel Fonstad, Suresh Agarwal, Suhas Patil, Bharathi Vennapusa, June Clements, Carol Jones, Sutini Ngadiman, Azita Djalilvand, Tracie Gardner, Charles Bechert, Christoph Guetter. Roche/Ventana Medical Systems, Mountain View, CA. 297 Multiplex Cocktails for Immunotherapy Targets: PD-L1 with Tumor Specific Transcription Factors (2107) David Altree-Tacha, Wei Yuan, George Yang. Biocare Medical, Concord, CA. 298 TTF-1 and Napsin A Expression in Lung Adenocarcinoma- Evaluation by Double Stain Immunohistochemistry and RNA ISH Assay (2143) Claudia Ormenisan Gherasim, Diane Lawson, Wanhong Jiang, Momin T Siddiqui, Cynthia Cohen. Emory University, Atlanta, GA. 158

219 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Characterizing FoxM1 Immunoexpression of Clear Cell and Papillary Renal Cell Carcinoma Employing Vectra Automated Multispectral Imaging System (2150) Snehal Sonawane, Ryan Deaton, Alexandru Susma, Shankar Sonawane, Frederick Behm, Grace Guzman, Suman Setty. University of Illinois Hospital & Health Sciences System, Chicago, IL; Vizient Inc, Chicago, IL. 307 Novel Herceptin-Based IHC Test Detects HER2+ Breast Cancers Correlating to Responses to HER2-Targeted Therapy (2128) Jian He, Zhiqing Zhang, Shuo Chen, Angelina Motiee, Yonghua Zhang, Songqing Zhao, Jianfu Wang, Constance T Albarracin, Susan Abraham, Yun Wu. UT MD Anderson Cancer Center, Houston, TX; Novodiax, Inc., Haywood, CA. 300 Immunohistochemistry in Lymphomas with Crush Artifacts (2127) Monira Haque, Jacek Polski. University of South Alabama, Mobile, AL. 301 A New Pan-Cytokeratin Antibody for Frozen/Fresh Tissues (2155) Jianfu Wang, Yonghua Zhang, Zhiqing Zhang, Angelina Motiee. Novodiax Inc, Hayward, CA. 302 Application of Hematoxylin and Eosin Staining as Counter Stain to Improve Immunohistochemistry Interpretation (2106) Roula Albadine, Kevin Loayza-Vega, Eloise Adam- Granger, Andrée-Anne Grosset, Maria-Claudia Vladoiu, Dominique Trudel. CHUM, Montreal, QC, Canada. 303 MicroRNA Profiling Complements Microscopic/ Mutational Analysis by Defining Alternative Pathways of Carcinogenesis (2111) Joseph F Annunziata, Anna Banizs, Christina M Narick, Sara Jackson, Jan F Silverman, Sydney Finkelstein. Allegheny General Hospital, Pittsburgh, PA; Interpace Diagnostics, Pittsburgh, PA. 304 Establishing a Pyrosequencing Assay for Determination of MLH1 Methylation Status (2149) Jan Seitz, Evgeny Moskalev, Florian Haller, Gerhard Seitz, Arndt Hartmann. Friedrich-Alexander University, Erlangen, Germany; Klinikum Bamberg, Bamberg, Germany. 305 DDX4 A Novel Immunohistochemical Marker for Immature Germ Cells and a Valuable Tool for Infertility Testicular Biopsy Evaluation (2123) Nazneen Fatima, Rajen Goyal, Lu Wang, Robert E Brannigan, Ximing J Yang. Northwestern Memorial Hospital, Chicago, IL. 306 Characterization of B- and T-cell Immune Repertoires with Anchored Multiplex PCR and Next-Generation Sequencing (2121) Jens Eberlein, Thomas Harrison, Ian McKittrick, Megan Wemmer, Laura Griffin, Brady P Culver, Laura A Johnson, Brian Kudlow. ArcherDX, Inc., Boulder, CO. TECHNIQUES (INCLUDING ULTRASTRUCTURE) 308 Ultrastructural Evaluation of Dendritic Cells in Light Chain-Mediated Acute Tubulointerstitial Nephritis (2118) Mingyu Cheng, Jiamin Teng, Guillermo A Herrera. Louisiana State University Health Sciences Center, Shreveport, LA. 309 Role of Electronic Microscopy in Evaluation of Hereditary Hyperbilirubinaemia A Clinicopathological Correlation Study of 24 Cases (2160) Japing Zhang, Zichang Yin, Dongfeng Tan. KingMed College of Laboratory Medicine, Guangzhou, Guangdong, China; MD Anderson Cancer Center, Houston, TX. 310 Glomerular Endothelial Cells Contribute to Circulating Endothelial Microparticles in Patients with Diabetic Glomerulopathy (2126) Xin Gu, Jehan A Abdulsattar, Guillermo A Herrera. LSUHSC-Shreveport, Shreveport, LA. 311 Short Duration Rapid Chilling of Mastectomy Specimens Improves Gross Examination for Breast Cancer and Optimally Preserves DNA for Molecular Studies (2134) Asangi R Kumarapeli, William Bellamy, Ericka Olgaard, Nicole Massoll, Soheila Korourian. University of Arkansas for Medical Sciences, Little Rock, AR. 312 Optimal Conditions of FFPE Samples for Extraction and Molecular Analysis of DNA for Atomic Bomb Survivors (2142) Takashi Ohnoda, Katsuya Matsuda, Yuko Akazawa, Nozomi Ueki, Yuka Yamaguchi, Shiro Miura, Akira Kinoshita, Koh-ichiro Yoshiura, Masahiro Nakashima. Nagasaki University School of Medicine, Nagasaki, Japan; Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan; Nagasaki University Hospital, Nagasaki, Japan; Atomic Bomb Disease Institute, Nagasaki, Nagasaki, Japan. 159

220 ABSTRACTS POSTER SESSION POSTER SESSION II Monday, March Day, 06, Date, :00 0:00 PM AM - 4:30-0:00 PM PMExhibit Hall Pathologic Quantification of Low Volume Discontinuous Metastatic Tumor Deposits (DMTD) in a Lymph Node (LN) Analysis of AJCC 8 th Ed. Cancer Staging Manual and Survey of Expert Surgical Pathologists (2133) Oleksandr N Kryvenko, Mahul B Amin, Henry D Appelman, Pedram Argani, John N Eble, Jonathan I Epstein, Linda Ferrell, John R Goldblum, Carmen Gomez-Fernandez, John C Kwok-Cheung, Merce Jorda, Ricardo V Lloyd, Martin C Mihm, Mehrdad Nadji, Victor E Reuter, Mark R Wick, Andrew E Rosenberg. University of Miami and Many Others, Miami, FL. 314 Smart Nanomotors: Towards In Vivo Sensing (2132) Bincy Jose, Sharon O Toole, Robert Forster, John J O Leary. Trinity College Dublin, Dublin, Ireland; Dublin City University, Dublin, Ireland; The Coombe Women & Infants University Hospital, Dublin, Ireland. 315 Ability of Desorption Electrospray Ionization (DESI) Mass Spectrometry Imaging (MSI) to Discriminate Between Tumors and Non-Neoplastic Tissue in Resection Specimens from Multiple Organs (2145) Kevin Yi Mi Ren, Martin Kaufmann, Nicole Morse, Amanda Shuo Xu, John Rudan, David Berman, Sonal Varma. Queen s University, Kingston, ON, Canada. 316 Improving Diagnostic Accuracy in the Pathology Workflow by Integration of Raman Microscopy (2125) Andrée-Anne Grosset, Catherine St-Pierre, Michael Jermyn, Kelly Aubertin, André Kougioumoutzakis, Marion Pineau, Karl St-Arnaud, Maria C Vladoiu, Frédéric Leblond, Dominique Trudel. Centre de Recherche du Centre Hospitalier de l Université de Montréal (CRCHUM), Montreal, QC, Canada; Université de Montréal, Montreal, QC, Canada; Polytechnique Montreal, Montreal, QC, Canada; Dartmouth College, Hanover, NH; Centre Hospitalier de l Université de Montréal (CHUM), Montreal, QC, Canada. 317 Role of phlip Imaging in Urological Malignancies (2108) Ali Amin, Jovana Golijanin, Anna Moshnicova, Joseph Brito, Timothy Tran, Ramona-Cosmina Adochite, Oleg A Andreev, Troy Crawford, Donald M Engelman, Gregory Andreev, Yana K Reshetnyak, Dragan Golijanin. Brown University, Providence, RI; University of Rhode Island, North Kingston, RI; Yale University, New Haven, CT. 318 Solvent Fee Environmentally Friendly IHC (2130) Alfonso Heras, Chase V Furler, Carolyn M Wall. BIO SB, Inc., Santa Barbara, CA. 319 High Efficiency Multiplexing for Personalized Medicine (2136) Marco Manzoni, Carla R Scalia, Maddalena M Bolognesi, Giorgio Cattoretti. Università degli Studi di Milano-Bicocca, Monza, Italy; Ospedale San Gerardo, Monza, Italy. 320 Correlation of Digital Slides with Raman Spectroscopy: Recommendations for Robust High-Precision Prostate Cancer Detection (2152) Vincent Q Trinh, Kelly Aubertin, Andrée-Anne Grosset, Maria C Vladoiu, Catherine St-Pierre, Fred Saad, Mike Jermyn, Frédéric Leblond, Dominique Trudel. Centre Hospitalier de l Université de Montréal, Montreal, QC, Canada; Centre de recherche du CHUM & Montreal Institute of Cancer, Montreal, QC, Canada. 321 In Situ Classification of Inflammatory Bowel Disease via Mass Spectrometry Tissue Typing (2157) Axel Wellmann, Oliver Klein, Franz Fogt, Tobias Boskamp. Institute of Pathology, Celle, Germany; Berlin- Brandenburger Centrum für Regenerative Therapien, Charité Universitätsmedizin Berlin, Berlin, Germany; University of Pennsylvania and the Presbyterian Medical Center of Philadelphia, Philadelphia, PA; Center for Industrial Mathematics, University of Bremen, Bremen, Germany. PROFFERED PAPERS Tuesday, March 07, :00 AM 12:00 PM CC HEMISFAIR 1 SECTION A GENITOURINARY CHAIRED BY: DONNA HANSEL AND GLADELL P PANER 8:00 Small Cell Carcinoma of the Urinary Bladder: A Clinicopathologic Analysis of 81 Cases (1071) Gang Wang, Li Xiao, Miao Zhang, Bogdan Czerniak, Charles Guo. UT MD Anderson Cancer Center, Houston, TX. 8:15 Comparative Study of TERT Promoter Mutation Status in Urothelial Carcinomas with Divergent Differentiation (868) Noah Brown, Madelyn Lew, Helmut Weigelin, Bryan Betz, Rohit Mehra. University of Michigan, Ann Arbor, MI. 160

221 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:30 Comparison of Genomic Alterations in Urothelial Carcinoma (UC) with and without TERT Promoter Mutation Using a Next-Generation Sequencing (NGS) Assay (850) Hikmat Al-Ahmadie, Isharwal Sumit, François Audenet, Eugene J Pietzak, Eugene K Cha, Anuradha Gopalan, Ying-Bei Chen, Joseph S Sirintrapun, Samson W Fine, Satish K Tickoo, Victor E Reuter, Jonathan E Rosenberg, Bernard H Bochner, Dean F Bajorin, Ahmet Zehir, Barry S Taylor, Michael F Berger, Gopa Iyer, David Solit. Memorial Sloan Kettering Cancer Center, New York, NY. 8:45 Molecular Characterization of Luminal and Basal Subtypes of Bladder Cancer (883) Vipulkumar Dadhania, Miao Zhang, Li Zhang, Jolanta Bondaruk, Tadeusz Majewski, Arlene Siefker-Radtke, Charles Guo, Colin Dinney, David E Cogdell, Shizhen Zhang, Sangkyou Lee, June G Lee, John N Weinstein, Keith Baggerly, David McConkey, Bogdan Czerniak. The University of Texas MD Anderson Cancer Center, Houston, TX. 9:00 Morphologic Variants of Bladder Cancer and Markers of Molecular Subtype (1074) Joshua I Warrick, Matthew Kaag, Jay Raman, Wilson Chan, Truc Tran, Sudhir Kunchala, David J DeGraff, Guoli Chen. Penn State University College of Medicine, Hershey, PA. 9:15 Genomic Alterations in Primary Bladder Adenocarcinoma and Urachal Adenocarcinoma (1058) Antoun Toubaji, Emmet J Jordan, Neil Desai, Anuradha Gopalan, Ying-Bei Chen, Samson W Fine, Sahussapont J Sirintrapun, Satish K Tickoo, Bernard H Bochner, Guido Dalbagni, Eugene K Cha, Dean F Bajorin, Jonathan E Rosenberg, Barry S Taylor, Michael F Berger, Victor E Reuter, David Solit, Gopa Iyer, Hikmat Al-Ahmadie. Memorial Sloan Kettering Cancer Center, New York, NY. 11:00 Urothelial Carcinoma In-Situ of the Bladder with Glandular Differentiation: Report of 92 Cases (1084) Zhiming Yang, Jonathan I Epstein. The Johns Hopkins Hospital, Baltimore, MD. 11:15 Large Nested Variant of Urothelial Carcinoma (UC): A Clinicopathologic Study of 36 Cases (881) Eva Comperat, Jesse K McKenney, Arndt Hartmann, Simone Bertz, Ondrej Hes, Fadi Brimo. Hopital Tenon, UPMC, Paris, France; Cleveland Clinic, Cleveland, OH; Pathologisches Institut, University Erlangen-Nürnberg, Erlangen, Germany; Charles University, Plzen, Czech Republic; McGill University Health Center, Montreal, Canada. 11:30 Primary Signet Ring Stromal Tumor of the Testis: A Study of 15 Cases Revealing Their Relationship to Pancreatic Analogue Solid Pseudopapillary Neoplasm Arising in Paratesticular Location (984) Kvetoslava Michalova, Michael Michal, Dmitry V Kazakov, Monika Sedivcova, Ondrej Hes, Ladislav Hadravsky, Abbas Agaimy, Maria Tretiakova, Carlos E Bacchi, Arndt Hartmann, Naoto Kuroda, Stela Bulimbasic, Marijana Coric, Tatjana Antic, Michal Michal. Faculty of Medicine in Plzen and Charles University Hospital, Plzen, Czech Republic; Biomedical Center, Faculty of Medicine in Plzen and Charles University Hospital, Plzen, Czech Republic; Biopticka Laborator s.r.o., Plzen, Czech Republic; 3rd Medical Faculty and Charles University Hospital Royal Vineyards, Prague, Czech Republic; University Hospital, Friedrich- Alexander University Erlangen-Nuremberg, Erlangen, Germany; University of Washington, Seattle, WA; Botucatu, SP, Brazil; Kochi Red Cross Hospital, Kochi, Japan; University Hospital Centre, Zagreb, Croatia; The University of Chicago, Chicago, IL. 11:45 Percentage of Germ Cell Tumor Components in Non- Seminomatous Germ Cell Tumor: Clinical Significance in Current Treatment Era (1087) Miao Zhang, Hasan Samra, Shi-MIng Tu, Pheroze Tamboli. MD Anderson Cancer Center, Houston, TX; Medical College of Wisconsin, Milwaukee, WI. 12:00 BREAK CC HEMISFAIR 3 SECTION B BREAST CHAIRED BY: KIMBERLY H ALLISON AND MARA H RENDI 8:00 Should Women Assessed at Screening and Diagnosed with ADH on Core Needle Biopsy Be Included in Trials of Active Surveillance for Low Risk DCIS? (153) Gelareh Farshid, James Kollias, Peter G Gill. BreastScreen SA, Adelaide, South Australia, Australia; SA Pathology, Adelaide, South Australia, Australia; Adelaide University, Adelaide, South Australia, Australia. 8:15 Histopathologic Correlates of Non-Mass Enhancement Detected by Breast MRI (284) Vanda Torous, Nancy Resteghini, Jordana Phillips, Vandana Dialani, Stuart J Schnitt, Priscilla J Slanetz, Gabrielle Baker. Beth Israel Deaconess Medical Center, Boston, MA; BIDMC, Boston, MA. 8:30 Flat Epithelial Atypia on Core Biopsy Is Not Associated with Upstage at Excision (182) Sarah B Hugar, Rohit Bhargava, David J Dabbs, Beth Z Clark. University of Pittsburgh Medical Center, Pittsburgh, PA. 161

222 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:45 Underestimationof Ductal Carcinoma In Situ at Core Needle Biopsy (105) Sophia Apple. City of Hope, Duarte, CA. 9:00 Not All Ductal Carcinoma In Situ (DCIS) Are Created IDLE (Indolent Lesions of Epithelial Origin) (103) Melissa Alexander, Anupma Nayak, Shabnam Jaffer. Icahn School of Medicine at Mount Sinai, New York, NY. 9:15 Feasibility of the Less Is More Approach in Treating Low Grade DCIS Diagnosed on Core Needle Biopsy: A 10 Year Review of DCIS Upgraded to Invasion at Surgery (250) Mirna B Podoll, Emily Reisenbichler, Andrew Bruner, Lania Roland, Sarah Mizuguchi, Mary Ann Sanders. Vanderbilt University, Nashville, TN; University of Louisville, Louisville, KY. 11:00 Inter-Observer Variability in Diagnosing Lobular Carcinoma-In-Situ Subtypes; Evaluating Reproducibility of Contemporary Criteria (272) Kamaljeet Singh, Cherie Paquette, Elizabeth T Kalife, Yihong Wang, Shamlal Mangray, M Ruhul Quddus, Margaret M Steinhoff. Alpert Medical School of Brown University and Women and Infants Hospital of Rhode Island, Providence, RI; Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI. 11:15 Clinicopathologic Review of Non-Classic Lobular Carcinoma In Situ Variants at a Single Academic Center (267) Eliah Shamir, Tianming Chu, Joseph T Rabban, Yunn-Yi Chen, Gregor Krings. UCSF, San Francisco, CA. 11:30 HER2 Somatic Mutation Analysis in Breast Cancer: Correlation with Clinicopathologic Features (147) Qingqing Ding, Hui Chen, Bora Lim, Senthil Damodaran, Weiwei Chen, Debu Tripathy, Sarina A Piha-Paul, Rajyalakshmi Luthra, Russell R Broaddus, Funda Meric-Bernstam, Aysegul A Sahin. MD Anderson Cancer Center, Huoston, TX. 11:45 Incidence and Significance of Fluorescent In Situ Hybridization (FISH) HER2 Gene Amplification by HER2 Gene Copy of > 6.0 with Her2/CEP17 Ratio of < 2.0 in Breast Cancer (106) Sophia Apple. City of Hope, Duarte, CA; UCLA, Los Angeles, CA. 12:00 BREAK CC 225 SECTION C HEMATOPATHOLOGY CHAIRED BY: ROBERT OHGAMI AND KAAREN K REICHARD 8:00 RNA/RNA-Binding Protein-Mediated Drug-Responsive Chromatin Structures and the Underlying Genetic Alterations in Myeloid Neoplasms (1370) Li Chen, Adam Cloe, Yuan Li, Ming Yue, Jason Cheng. University of Chicago, Chicago, IL; The First Hospital of Peking University, Beijing, China. 8:15 Correlation of Flow Cytometric, Cytogenetic, and NGS Testing in Chronic Myelomonocytic Leukemia (1386) Anna Dolezal, David W Bahler, Mohamed Salama. University of Utah, Salt Lake City, UT. 8:30 Familial Platelet Disorder with Propensity to Myeloid Malignancy (FPDMM) Associated with Germline RUNX1 Mutation Shows Characteristic Morphologic Features (1429) Rashmi Kanagal-Shamanna, Sanam Loghavi, L Jeffrey Medeiros, Mark J Routbort, Carlos E Bueso-Ramos, Joseph Khoury. M.D. Anderson Cancer Center, Houston, TX. 8:45 NPM1 Mutations Are a Secondary Genetic Event in NPM1-Mutated Acute Myeloid Leukemia (1477) Jay L Patel, Jonathan Schumacher, Philippe Szankasi, Kimberly Frizzell, Shelly Sorrells, Wei Shen, Adam Clayton, Rakhi Jattani, Todd W Kelley. University of Utah, Salt Lake City, UT; ARUP Laboratories, Salt Lake City, UT. 9:00 Therapy-Related Myeloid Neoplasm Has a Higher Subclonal Mutation Burden Than De Novo AML (1555) Gang Zheng, Aparna Pallavajjalla, Lisa Haley, Ming- Tseh Lin, James R Eshleman, Lukasz Gondek, Michael Borowitz, Amy Duffield, Kathleen H Burns, Christopher D Gocke. The Johns Hopkins Hospital, Baltimore, MD. 9:15 Both Mutations and Morphology Independently Predict Prognosis in De Novo AML with Intermediate-Risk Karyotype (1543) Olga K Weinberg, Christopher J Gibson, Olga Pozdnyakova, Frank C Kuo, Benjamin Ebert, Robert P Hasserjian. Boston Children s Hospital 2. Brigham and Women s Hospital 3. Massachusetts General Hospital, Boston, MA. 11:00 Acute Myeloid Leukemia with Erythroid Predominance: Are All Cases MDS-Related? (1452) Elizabeth Margolskee, Geoffrey Mikita, Jean Oak, M B Allen, Zhuang Zuo, Sa Wang, Daniel A Arber, Tracy George, Robert P Hasserjian, Attilio Orazi. Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY; Stanford University, Stanford, CA; University of New Mexico, Albuquerque, NM; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Massachusetts General Hospital, Boston, MA. 162

223 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 11:15 TP53 Mutations with a Normal Karyotype in Myelodysplastic Syndromes and Cytopenia(s) of Unknown Significance (1539) Wei Wang, Mark J Routbort, Chi Y Ok, Keyur P Patel, Raja Luthra, L Jeffrey Medeiros, Sa Wang. MD Anderson Cancer Center, Houston, TX. 11:30 Mutational Analysis of Bone Marrows of Patients with Reactive Cytopenias by Next Generation Sequencing (1523) Vinushree Swamy, Diana Haninger, Elizabeth Settembre, Cecilia Ramirez-Santrich, Mehdi Nassiri, Magdalena Czader. Indiana University School of Medicine, Indianapolis, IN. 11:45 The Incidence of Background Clonal Hematopoiesis in Lymphoplasmacytic Lymphoma (1433) Annette S Kim, Elizabeth A Morgan. Brigham & Women s Hospital, Boston, MA. 12:00 BREAK CC 221 SECTION D GASTROINTESTINAL CHAIRED BY: JOEL GREENSON AND DEEPA T PATIL 8:00 DNA Flow Cytometric Analysis of Barrett s Esophagus- Related Dysplasia Using Paraffin-Embedded Tissue: DNA Content Abnormality Can Serve as Both Diagnostic Marker of Dysplasia and Predictive Marker of Neoplastic Progression (661) Won-Tak Choi, Peter S Rabinovitch, Thomas Small, Danning Huang, Aras N Mattis, Sanjay Kakar. UCSF Medical Center, San Francisco, CA; University of Washington, Seattle, WA; SUNY Upstate Medical University, Syracuse, NY. 8:15 Lateral Spread in Esophageal Squamous Cell Neoplasia (679) Ogechukwu Pearl Eze, Yaman Tarabishy, Kevin Waters, Maryam Pezhouh, Lothar Veits, Andrea May, Christian Ell, Elizabeth A Montgomery, Michael Vieth. Johns Hopkins Hospital, Baltimore, MD; Klinikum Bayreuth, Bayreuth, Germany. 8:30 Aurora Kinase A Expression in Primary Resections of Gastrointestinal Stromal Tumors: Implications for Prognosis and Treatment Response (745) Daniel F Marker, Michael Landau. University of Pittsburgh Medical Center, Pittsburgh, PA. 8:45 Recent Increase in Gastric Carcinoma and Characterization of Gastric Polyp Burden in Western Patients with FAP (706) Rahul Jawale, Gautam Mankaney, Pamela Leone, Lisa LaGuardia, Margaret O Malley, James Church, Carol Burke, Deepa T Patil, Scott Robertson, Michael Cruise. Cleveland Clinic, Cleveland, OH. 9:00 The Autophagy-Associated ATG16L1 Thr300Ala Polymorphism Affects Outcome of Gastric Adenocarcinoma Patients (735) Changqing Ma, Ta-Chiang Liu. University of Pittsburgh, Pittsburgh, PA; Washington University, St. Louis, MO. 9:15 Programmed Death-Ligand 1 Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and HER2-Negative Status (822) Lei Wang, Shengnan Zhao, Shujuan Ni, Cong Tan, Dan Huang, Weiqi Sheng. Fudan University Shanghai Cancer Center, Shanghai, China. 11:00 Immune Microenvironment and Clinical Outcomes in Gastric Carcinoma (777) Pallavi A Patil, Li J Wang, Kara A Lombardo, Thomas J Miner, Andres Matoso. Brown University and Rhode Island Hospital, Providence, RI; Brown University and The Miriam Hospital, Providence, RI. 11:15 Small Bowel Carcinomas Associated with Celiac Disease Are Characterized by the Concomitant Presence of Nuclear β-catenin Accumulation and Microsatellite Instability (819) Alessandro Vanoli, Michele Martino, Daniela Furlan, Federica Grillo, Gabriella Nesi, Claudia Mescoli, Daniele Fornino, Ombretta Luinetti, Fausto Sessa, Antonio Di Sabatino, Gino R Corazza, Enrico Solcia. University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; University of Insubria, Varese, Italy; San Martino/IST University Hospital, Genova, Italy; University of Florence, Florence, Italy; University of Padua, Padua, Italy. 11:30 Clinical Significance of Monoclonal T-Cell Populations in Duodenal Lymphocytosis: Celiac and Non-Celiac Patients (652) Romulo Celli, Pei Hui, Sidney Bogardus, Marie Robert. Yale Medical School, New Haven, CT. 11:45 Examination of Luminal Debris Aids Distinction Between Peptic Ulcers and Ulcerated Gastric Cancers (696) Erika Hissong, Jose Jessurun, Rhonda K Yantiss. New York Presbyterian-Weill Cornell Medicine, New York, NY. 12:00 BREAK CC 304 SECTION E GYNECOLOGIC CHAIRED BY: ANNE MILLS AND PATRICIA SHAW 8:00 Trefoil Factor Family 2 Protein: A Promising Immunohistochemical Marker for Diagnosing Lobular Endocervical Glandular Hyperplasia and Gastric-Type Adenocarcinoma of Uterine Cervix (1102) Shiho Asaka, Hiroyoshi Ota. Shinshu University Hospital, Matsumoto, Nagano, Japan; Shinshu University School of Medicine, Matsumoto, Nagano, Japan. 163

224 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:15 International Endocervical Adenocarcinoma Criteria and Classification (IECC) (1244) Simona Stolnicu, Iulia Barsan, Lien Hoang, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Kay Park, Esther Oliva, Robert Soslow. University of Medicine and Pharmacy, Targu Mures, Mures, Romania; Vancouver General Hospital, Vancouver, Canada; Oncologic Institute, Iasi, Romania; Ospedale Sacro Coure Don Calabria, Negrar, Italy; Sheba Medical Center, Tel-Hashomer, Israel; Jikei University School of Medicine, Tokyo, Japan; Hospital de Oncologia, Mexico City, Mexico; MSKCC, New York, NY; Massachusetts General Hospital, Massachusetts, MA. 8:30 Somatic Mutations in Cancer Driver Genes in Endometriosis in the Absence of Dysplasia or Cancer (1238) Ie-Ming Shih, Ayse Ahan, Tian-Li Wang, Hiroshi Ogawa, Nicholas Papadopoulos. Johns Hopkins, Baltimore, MD; Seirei Mikatahara Hospital, Hamamatsu, Japan. 8:45 Morphological Reproducibility, Genotyping and Immunohistochemical Profiling Do Not Support a Category of Seromucinous Carcinoma of the Ovary (1183) Martin Kobel, Peter F Rambau, John B McIntyre, Jennifer Taylor, Sandra Lee, Travis Ogilvie, Anna Sienko, Don Morris, Maire Duggan, W Glenn McCluggage. University of Calgary, Calgary, AB, Canada; Tom Baker Cancer Centre, Calgary, AB, Canada; Belfast Health and Social Care Trust, Belfast, United Kingdom. 9:00 Sertoli-Leydig Cell Tumors: Examination of Morphologic Features and Correlation with Germline and Somatic DICER 1 Mutation (1251) Tatjana Terzic, Colin J Stewart, Leanne De Kock, William Foulkes, W Glenn McCluggage, Patricia Shaw, Blaise Clarke. University of Toronto, University Health Network, Toronto, ON, Canada; School for Women s and Infants Health, University of Western Australia, Perth, WA, Australia; McGill University, Montreal, QC, Canada; Belfast Health and Social Care Trust, Royal Group of Hospitals Trust, Belfast, United Kingdom. 9:15 Mutational Analysis of BRAF and KRAS in Ovarian Serous Borderline Tumors (SBTs) and Their Subsequent Serous Carcinomas (1271) Deyin Xing, Felix Zeppernick, Yohan Suryo Rahmanto, Charlotte G Hannibal, Susanne K Kjaer, Robert Kurman, Tian-Li Wang, Ie-Ming Shih, Russell Vang. Johns Hopkins Medical Institute, Baltimore, MD; Danish Cancer Society Research Center, Copenhagen, Denmark. 11:00 Ovarian Serous Carcinomas with Mixed Features of High Grade and Low Grade Serous Carcinoma Display Heterogeneous Genome Wide Copy Variation Profiles (1278) Shabnam Zarei, Chen Wang, Jean-Pierre A Kocher, Yan Wang, Debra A Bell, Sarah E Kerr. Mayo Clinic, Rochester, MN. 11:15 Targeted Genomic Profiling of Ovarian and Peritoneal Low-Grade Serous Carcinomas (LGSC) with Clinicopathologic Correlation (1242) T Rinda Soong, Lynette M Sholl, Michele T Baltay, Bradley J Quade, Michelle S Hirsch, Christopher P Crum, Marisa R Nucci, Brooke E Howitt. Brigham and Women s Hospital, Boston, MA. 11:30 Tubal and Ovarian Epithelial Cancer in Women with Germline Mutations Other Than the BRCA and Lynch Syndrome Genes (1176) Yuna Kang, Lee-may Chen, Julie Mak, Joseph Rabban. UCSF, San Francisco, CA. 11:45 Appendectomy in the Setting of Mucinous Neoplasia of the Ovary: Entire Submission of a Grossly Normal Appendix Is Unneccessary (1140) Elizabeth Euscher, Preetha Ramalingam, Anais Malpica. MD Anderson, Houston, TX. 12:00 BREAK CC 301 SECTION F CYTOPATHOLOGY CHAIRED BY: SARAH E KERR AND MING JIN 8:00 Impact of New Nomenclature Non-Invasive Follicular Neoplasm with Papillary Like Nuclear Features on the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). An Institutional Experience (449) Maryam Shahi, Hira Yousaf, Khalid Amin, Faqian Li. University of Minnesota, Minneapolis, MN. 8:15 Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Its Influence on the False Positive Rate in Thyroid Cytopathology (425) N Paul Ohori, Jenna Wolfe, Linwah Yip, Shane O LeBeau, Sally E Carty, Aaron N Berg, Karen E Schoedel, Yuri Nikiforov, Raja R Seethala. University of Pittsburgh Medical Center, Pittsburgh, PA. 8:30 Diagnosis Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Fetaures (NIFTP): Implications on the Risk of Malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) (490) Haijun Zhou, Zubair Baloch, Tommaso Bizzarro, Guido Fadda, Deepti Adhikari Guragain, Joseph Hatem, Luigi M Larocca, Ritu Nayar, Julia Samolczyk, Jamie Slade, Esther Rossi. Northwestern University, Chicago, IL; Hospital of the University of Pennsylvania, Philadelphia, PA; Catholic University, Rome, Italy. 164

225 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 8:45 Correlation of Cytomorphologic Features and Mutational Profile of Thyroid Nodules with Indeterminate Cytologic Diagnosis (450) Maryam Shahi, Rupendra Shrestha, Rachel I Vogel, Maria Evasovich, Lynn A Burmeister, Khalid Amin. University of Minnesota, Minneapolis, MN. 9:00 Diagnosis of Solid Parathyroid Lesions Presenting as Intrathyroidal/Exophytic Thyroid Nodules on Aspiration Biopsy: A Correlation of Clinical Data, Ancillary Studies, and Molecular Analysis (352) Margaret Cho, Thaira Oweity, Tamar C Brandler, Karen Fried, Pascale Levine. New York University School of Medicine, New York, NY; Lenox Hill, New York, NY. 9:15 Improved Interpretation of Bile Duct Brushings Requires Intensive Exposure and Familiarity with Diagnostic Criteria (417) Bahar Memis, Vaidehi Avadhani, Krisztina Z Hanley, Ezgi Hacihasanoglu, Uma Krishnamurti, Adeboye O Osunkoya, Alyssa Krasinskas, Michael M Goodman, Rebecca Nash, Volkan Adsay, Michelle D Reid. Emory Uni, Atlanta, GA. 11:00 Successful Utilization of Pre-Stained Cytology Smears as a Source of Material for Targeted Next Generation Sequencing (NGS) in Clinical Practice: An Institutional Experience (433) Rongqin Ren, Nabil Ashraf, Catherine I Dumur, Jorge A Almenara, Michael O Idowu, Celeste N Powers, Adele O Kraft. Virginia Commonwealth University Health System, Richmond, VA. 11:15 Detection of Gene Fusions Using Cytology Smears and a Next-Generation Sequencing-Based Assay (384) Omar Jaber, Natalya Guseva, Aaron A Stence, Aaron Bossler, Chris Jensen, Deqin Ma. University of Iowa, Iowa City, IA. 11:30 Characterization of PD-L1 Immunohistochemical Expression in Cell Block Preparations with Different Fixatives (405) Isaac E Lloyd, Wenhua Zhou, Benjamin L Witt, Barbara E Chadwick. University of Utah and ARUP Laboratories, Salt Lake City, UT; ARUP Laboratories, Salt Lake City, UT. 11:45 Cytologic-Histologic Correlation of PD-L1 Immunohistochemistry in Lung Carcinomas (441) Eleanor Russell-Goldman, Lynette M Sholl, Marina Vivero. Brigham and Women s Hospital, Boston, MA. 12:00 BREAK CC 302 SECTION G BONE & SOFT TISSUE CHAIRED BY: MEERA HAMEED AND KHIN THWAY 8:00 Myopericytomatosis: Clinicopathologic Analysis of a Series of 11 Cases with Molecular Identification of Recurrent PDGFRB Alterations (51) Yin (Rex) Hung, Christopher DM Fletcher. Brigham and Women s Hospital, Harvard Medical School, Boston, MA. 8:15 Recurrent SRF-RELA Fusions Define a Novel Subset of Cellular Myofibroblastic Neoplasms in the Spectrum of Cellular Myofibroma/Myopericytoma: A Potential Diagnostic Pitfall with Sarcomas with Myogenic Differentiation (33) Cristina R Antonescu, Yun-Shao Sung, Lei Zhang, Narasimhan P Agaram, Christopher DM Fletcher. Memorial Sloan Kettering Cancer Ctr, New York, NY; Brigham and Women s Hospital, Boston, MA. 8:30 Composite Hemangioendothelioma (CHE) with Neuroendocrine (NE) Marker Expression: An Aggressive Variant (74) Kyle D Perry, Alyaa Al-lbraheemi, Brian P Rubin, William R Sukov, Jin Jen, Hongzheng Ren, Jang Jin, Asha Nair, Jaime Davila, Stefan Pambuccian, Andrew E Horvai, Henry D Tazelaar, Andrew L Folpe. Mayo Clinic, Rochester, MN; Cleveland Clinic, Cleveland, OH; Boston Children s Hospital, Boston, MA; Loyola Medical Center, Maywood, IL; UCSF, San Francisco, CA. 8:45 Neurofibromin C Terminus-Specific Antibody (clone NFC) Identifies NF1-Inactivated GIST (81) Sabrina Rossi, Daniela Gasparotto, Matilde Cacciatore, Maurizio Polano, Monia Niero, Alessia Mondello, Marta Sbaraglia, Erica Lorenzetto, Alessandra Mandolesi, Alessandro Gronchi, David E Reuss, Andreas von Deimling, Roberta Maestro, Angelo P Dei Tos. Treviso General Hospital, Treviso, Italy; CRO Aviano NCI, Aviano, Italy; University of Marche, Ancona, Italy; INT Milano NCI, Milano, Italy; University of Heidelberg, Heidelberg, Germany. 9:00 Clinicopathological and Molecular Characterization of SMARCA4-Deficient Thoracic Sarcomas with Comparisons to Potentially Related Disease Entities (98) Akihiko Yoshida, Eisuke Kobayashi, Takashi Kubo, Toru Motoi, Noriko Motoi, Akira Kawai, Takashi Kohno, Hiroshi Kishimoto, Hitoshi Ichikawa, Nobuyoshi Hiraoka. Naional Cancer Center, Tokyo, Japan; Komagome Hospital, Tokyo, Japan; Saitama Prefectural Children s Hospital, Saitama, Japan. 165

226 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 9:15 BRAF V600E Occurs in a Subset of Glomus Tumors, and Is Associated with Malignant Histological Characteristics (44) Nooshin K Dashti, Seung J Lee, Armita Bahrami, Fausto Rodriguez, Andrew L Folpe, Jennifer M Boland. Mayo Clinic, Rochester, MN; St. Jude Children s Research Hospital, Memphis, TN; Johns Hopkins Hospital, Baltimore, MD. 11:00 ETV Transcriptional Upregulation Is a More Reliable Diagnostic Tool in SBRCT with CIC Complex Abnormalities Compared to FISH and RNAseq Methods (56) Yu-Chien Kao, Yun-Shao Sung, Brendan C Dickson, David Swanson, Sumathi Vaiyapuri, Shih-Chiang Huang, Cristina R Antonescu. Memorial Sloan Kettering Cancer Ctr, New York, NY; Shuang Ho Hospital, Taipei, Taiwan; Mount Sinai Hospital, Toronto, ON, Canada; Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, United Kingdom; Chang Gung Memorial Hospital, Taoyuan, Taiwan. 11:15 FOSB Is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma (52) Yin (Rex) Hung, Christopher DM Fletcher, Jason L Hornick. Brigham and Women s Hospital, Harvard Medical School, Boston, MA. 11:30 Fibrocartilaginous Mesenchymoma of Bone: A Clinicopathologic and Molecular Analysis of 8 Cases from a Single Institution (47) Marco Gambarotti, Alberto Righi, Daniel Vanel, Stefania Cocchi, Stefania Benini, Francesca M Elli, Giovanna Mantovani, Pietro Ruggieri, Stefano Boriani, Davide M Donati, Marta Sbaraglia, Angelo P Dei Tos, Piero Picci. Rizzoli Orthopaedic Institute, Bologna, Italy; Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy; University of Padova, Padova, Italy; Treviso Regional Hospital, Treviso, Italy. 11:45 Telomerase Maintenance Mechanism in Chordomas (93) Jen-Wei Tsai, Alan Meeker, Hong Cheuk Leung, Heather Lin, Davis R Ingram, Samia Khan, Khalida Wani, Laurence D Rhines, Alexander J Lazar, Wei-Lien Wang. EDA Hospital, Kaohsiung, Taiwan; The University of Texas MD Anderson Cancer Center, Houston, TX; John Hopkins School of Medicine, Baltimore, MD. 12:00 BREAK CC 303 SECTION H LIVER CHAIRED BY: CYNTHIA GUY AND JOHN HART 8:00 SOX-9 Is Superior to Other Cancer Stem Cell Markers EpCAM and CK19 in Predicting Prognosis in Western Hepatocellular Carcinoma (1695) Marianna B Ruzinova, Elizabeth M Brunt, Neeta Vachharajani, William C Chapman, Ta-Chiang Liu. Washington University School of Medicine, St. Louis, MO. 8:15 Distinction of Intrahepatic Metastasis from Multicentric Carcinogenesis in Hepatocellular Carcinoma Using Molecular Markers (1688) Maryam Pezhouh, Peter Chianchiano, Amy Kim, Robert A Anders, Laura D Wood. Johns Hopkins Hospital, Towson, MD. 8:30 A Unique Group of Fibrolamellar Carcinomas Lack the Classic DNAJB1-PRKACA Fusion and Instead Have PRKAR1A Loss (1671) Rondell Graham, Karoline Lackner, Luigi Terracciano, Yessica González-Cantú, Joseph J Maleszewski, Patricia T Greipp, Michael S Torbenson. Mayo Clinic, Rochester, MN; Medical University of Graz, Graz, Austria; University Hospital Basel, Basel, Switzerland; Universidad Autónoma de Nuevo León, Nuevo León, Mexico. 8:45 A Point-Based Grading System for Hepatocellular Carcinoma Shows Improved Interobserver Agreement and Better Identifies Histologic Features Associated with Recurrent Disease After Liver Transplant (1692) Daniel E Roberts, Sanjay Kakar, Ryan M Gill. University of California, San Francisco, San Francisco, CA. 9:00 Various Oncogenic Pathways Are Associated with Distinct Immune and Cancer Gene Signatures in Inflammatory and HNF1a-Inactivated Hepatic Adenomas (1663) Jarish Cohen, Sarah E Umetsu, Sanjay Kakar, Zoltan Laszik. University of California, San Francisco, San Francisco, CA. 9:15 Atypical Hepatocellular Neoplasms: Mutational Profile and Copy Alterations (1676) Nancy M Joseph, Linda Ferrell, Sanjay Kakar. UCSF, San Francisco, CA. 11:00 Angiosarcoma of the Liver: Study of Morphologic Patterns and Report of Three Novel Variants (1709) Saba Yasir, Ian Clark, Michael S Torbenson. Mayo Clinic, Rochester, MN; Royal Free Hospital, London, United Kingdom. 166

227 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 8:00 PM AM - Exhibit 12:00 Hall PM 1 11:15 Hepatic Involvement in Hemophagocytic Lymphohistiocytosis (HLH) (1656) Lindsay Alpert, Heewon Kwak, Maria Westerhoff, Katherine Sun, Mojgan Hosseini, Rish K Pai, Shu-Yuan Xiao, John Hart. University of Chicago, Chicago, IL; University of Washington, Seattle, WA; NYU Medical Center, New York, NY; UC San Diego, San Diego, CA; Mayo Clinic, Scottsdale, AZ. 11:30 Metastatic Paragangliomas & Pheochromocytomas in Liver Are Challenging to Diagnose (1662) Ian Clark, Sounak Gupta, Michael S Torbenson, Michael Rivera. Royal Free Hospital, London, United Kingdom; Mayo Clinic, Rochester, MN. 11:45 Glutamine Synthetase Immunostaining in Regressed Cirrhosis (1673) Rouba Hadi, Kseniya Shin, Nicholas Reder, Lindsay Alpert, Lisa Koch, Won-Tak Choi, John Hart, Maria Westerhoff. University of Washington, Seattle, WA; University of Chicago, Chicago, IL; University of California San Francisco, San Francisco, CA. 12:00 BREAK POSTER SESSION III Tuesday, March 07, :30 AM 12:00 PM Exhibit Hall 1 AUTOPSY 1 Pathology Department Chair Attitudes Regarding Emphasis on Autopsy in Pathology Training (23) David S Priemer, Matthew Kuhar, John N Eble, George D Lundberg. Indiana University School of Medicine, Indianapolis, IN; Stanford University, Stanford, CA. 2 A Structured Autopsy Mortality Review Provides Important Information for Clinical Practice Improvement (8) Caroline Early, Karen Kelly, Bill Oliver, Mary Gilliland, Peter Kragel. Brody School of Medicine, Greenville, NC. 3 The Spectrum of Autopsy Findings of 119 Aborted Fetuses with Skeletal Disorders (7) Magdalena Dubova, Sarka Hadravska, Jiri Ferda, Ondrej Daum, Michal Michal. Biopticka Laborator s.r.o., Plzen, Czech Republic; Faculty Hospital Plzen, Medical Faculty, Charles University in Prague, Plzen, Czech Republic. 4 Role of Hospital Autopsy in Peri-Procedural Deaths: A 5 Year Retrospective Study (3) Baidarbhi Chakraborty, Xiaofeng Zhao, Xu Zeng, Nahum Duker, Abir Mukherjee. Temple University Hospital, Philadelphia, PA. 5 Fatal Disseminated Strongyloidiasis Secondary to Corticosteroid Use: A Report of Two Cases (14) Kailee Imperatore, Nicole Herring, Yumna Omarzai, Cristina Vincentelli, Vathany Sriganeshan. Mount Sinai Medical Center, Miami Beach, FL. 6 Longstanding Illness with No Definite Diagnosis: A Fatal Case of Undiagnosed Whipple s Disease (21) Aqsa Nasir, Lisa Lyons, Shannon M Mackey-Bojack, Brian Hartz, Joseph J Goswitz. University of Minnesota, Minneapolis, MN; Abbott Northwestern Hospital, Minneapolis, MN; Jesse E Edwards Registry of Cardiovascular Disease, United Hospital, Minneapolis, MN. 7 Significance of Pulmonary Calcifications (Corpora Amylacea and Osseous Metaplasia); a 10-Year Retrospective Autopsy Study (19) Lauren Mecca, David J Pisapia, Steven Salvatore. New York Presbyterian Hospital Weill Cornell Medicine, New York, NY. 8 Histologic and Molecular Findings of Heartland Virus (HRTV) at Autopsy: A Case Series Review (2) Kathleen Byrnes, Louis P Dehner. Washington University in St. Louis, St. Louis, MO. 9 Unusual Presentations of Pulmonary Amyloidosis at Autopsy (11) Jane Date Hon, Billie Fyfe-Kirschner. Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. 10 Clostridium Septicum Causing Fatal Sepsis in a Patient with Ovarian Cancer: A Case Report (1) Boulos Beshai, Stephen P Montgomery, Nancy Drotar, Teriza Shehatou. Hartford Hospital, Hartford, CT; Crouse Hospital, Syracuse, NY. 11 Metastatic Atypical Teratoid Rhabdoid Tumor (ATRT) in an Adolescent (22) Kwadwo Oduro, Ricard Masia, Maria Cobos Sillero, David Ebb, Eugene Mark, E Tessa Hedley-Whyte. Massachusetts General Hospital, Boston, MA; University of California Los Angeles, Los Angeles, CA. 167

228 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 12 A Novel Case of Liver-Restricted Burkitt Lymphoma in the Setting of Concomitant HBV and HCV Infections (30) Connor Zuraski, Katherine E Schwetye. Pathology, St Louis, MO. 13 A 20-Year Review of Hospital Autopsies in a Nigerian Tertiary Hospital (13) Nzechukwu Z Ikeri, Olakanmi R Akinde, Luqman Adebayo, Abdullateeph A Odukoya. Lagos University Teaching Hospital, Lagos, Lagos, Nigeria. 14 The Pathology of Eclampsia, an Autopsy Series (9) Jonathan Hecht, Jaume Ordi, S A Karumanchi, Zsuzsanna K Zsengeller, Elizabeth Pernicone, Seymour Rosen. Beth Israel Deaconess Medical Center, Boston, MA; Hospital Clinic, Institut d Investigac ions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. 15 Autopsy Findings Following Liver Transplantation: A Retrospective Review of 27 Cases at a Single Institution (15) Ryan D Jones, Guang-Yu Yang. Northwestern University, Chicago, IL. BREAST PATHOLOGY 16 Long-Term Clinical Outcome in 41 Cases of Low-Grade Adenosquamous Carcinoma of the Breast (115) Jordan E Baum, Sandra J Shin. Weill Cornell Medicine, New York, NY. 17 Inside-Out p120 Immunostaining Pattern in Invasive Micropapillary Carcinoma of Breast; Another Unequivocal Evidence of Reversed Polarity (206) Marcos Lepe, Elizabeth T Kalife, Joyce Ou, M Ruhul Quddus, Kamaljeet Singh. Alpert Medical School of Brown University and Women and Infants Hospital, Providence, RI. 18 Cell Cycle Aberrations and Diagnostic Utility of Rb and Cyclin D1 Immunohistochemistry in Mammary Myofibroblastomas (124) Vivek Charu, Rebecca Asch-Kendrick, Jessica Hicks, Rajni Sharma, Tamara L Lotan, Angelo M De Marzo, Pedram Argani, Ashley Cimino-Mathews. Johns Hopkins Hospital, Baltimore, MD. 19 Intra-Tumor Genetic Heterogeneity in Metaplastic Breast Carcinomas (161) Felipe Geyer, Kathleen A Burke, Anastasios D Papanastatiou, Gabriel S Macedo, Edi Brogi, Hannah Y Wen, Jorge Reis-Filho, Britta Weigelt. Memorial Sloan Kettering Cancer Center, New York, NY. 20 Expression of Molecules Involved in Cell-Extracellular Matrix(ECM) Adhesion Is Associated with Characteristic Micropapillary Morphology and Extensive Lymph Node Metastasis of Breast: Next-Generation Sequencing Analysis (131) Jinah Chu, Boram Lee, Je-Gun Joung, Woong-Yang Park, Eun Yoon Cho. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Samsung Medical Center, Seoul, Republic of Korea; Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea. 21 Estrogen Receptor-Positive and -Negative Adenomyoepitheliomas of the Breast Are Underpinned by Distinct Genetic Alterations (242) Fresia Pareja, Felipe Geyer, Kathleen A Burke, Marcia Edelweiss, Hannah Y Wen, Achim Jungbluth, Zsuzsanna Varga, Brian P Rubin, Britta Weigelt, Jorge Reis-Filho. Memorial Sloan Kettering Cancer Center, New York, NY; 2University Hospital Zurich, Zurich, Switzerland; Cleveland Clinic, Cleveland, OH. 22 Analysis of CDH1 in Invasive Lobular Carcinoma (ILC): Comparison of Morphology, Immunohistochemistry (IHC) and Mutation Profile Detected by Hybrid Capture- Based Next Generation Sequencing (NGS) (165) Anne Grabenstetter, Abhinita S Mohanty, Ahmet Zehir, Pedram Razavi, Jose Baselga, Lee K Tan, Dara S Ross. Memorial Sloan Kettering Cancer Center, New York, NY. 23 Genomic Profiling of Synchronous Bilateral Lobular Carcinoma (200) Gregor Krings, Yunn-Yi Chen, Kuang-Yu Jen. UCSF, San Francisco, CA; UC Davis, San Francisco, CA. 24 A Comparison Between the Clinicopathological Features of HER2 Positive versus HER2 Negative Invasive Lobular Carcinomas: A 7 Year Retrospective Analysis (189) Tejashree Karnik, Rashna Madan, Katie Dennis, Ossama Tawfik, Fang Fan. The University of Kansas Medical Center, Kansas City, KS. 25 Is Estrogen Receptor Positive (ER+) Progesterone Receptor Negative (PR-) Invasive Lobular Carcinoma a Distinct Clinicopathologic Subset? (157) Ramya Gadde, Dhananjay Chitale. Henry Ford Hospital, Detroit, MI. 26 Fibroepithelial Lesions of the Breast Involved by Atypical Epithelial Proliferations: A 12-Year Single Institution Study (271) Bart Singer, Chieh-Yu Lin, Robert West. Stanford University, Stanford, CA. 27 Paucity of Atypical Epithelial Proliferations in 379 Pediatric Fibroepithelial Breast Lesions (239) Ugur Ozerdem, Fattaneh Tavassoli. Yale University School of Medicine, New Haven, CT. 168

229 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 28 Epithelial Proliferations in Juvenille Fibroadenomas (167) Mihir Gudi, Jabed Iqbal, May Ying Leong, Puay Hoon Tan, HuiHua Li, Sudhanshi S Jain, Swee Ho Lim, Kuick Chik Hong. KK Hospital, Singapore, Singapore; Singapore General Hospital, Singapore, Singapore. 29 Accurate Diagnosis of Fibroepithelial Lesions of Breast on Core Needle Biopsy: A Multidisciplinary Approach (195) Mahsa Khanlari, Atousa Ordobazari, Paula Sofia Espinal, Geetika Klevos, Merce Jorda, Richard J Cote, Carmen Gomez-Fernandez. University of Miami, Miami, FL. 30 Size and Heterologous Elements Predict Metastases in Malignant Phyllodes Tumors of the Breast (198) Valerie Koh, Aye Aye Thike, Tze Wei Chng, Benjamin Yongcheng Tan, Puay Hoon Tan. Singapore General Hospital, Singapore, Singapore. 31 Mitotic Activity in Benign and Malignant Fibroepithelial Lesions (120) Caroline Brodie, Mark O Loughlin, Maura Cotter, Daniel O Callaghan, Sami Elwahab, Carmel Malone, Sine Phelan, Helen Ingoldsby, Birgit Tietz, Margaret Sheehan, Rachel Ennis, Ray McLaughlin. Galway University Hospital, Galway, Ireland; Irish National Breast Screening Programme, Galway, Ireland; National University of Ireland, Galway, Galway, Ireland. 32 Is Re-Excision of Benign and Borderline Phyllodes Tumors with Positive Margins Necessary? (135) Camilla Cristando, Mathilde Almekinders, Fresia Pareja, Zenica Bowser, Edi Brogi, Melissa Murray. MSKCC, NY, NY; Netherlands Cancer Institute, Amsterdam, Netherlands. 33 Validation of the Singapore Nomogram for Outcome Prediction in Breast Phyllodes Tumors in a Large Patient Cohort (129) Tze Wei Chng, Mihir Gudi, HuiHua Li, Puay Hoon Tan. Singapore General Hospital, Singapore, Singapore; KK Hospital, Singapore, Singapore. 34 Validation of the Singapore Nomogram for Outcome Prediction in a US-Based Population of Women with Breast Phyllodes Tumors (PT) (213) Camilla Cristando, HuiHua Li, Mathilde Almekinders, Puay Hoon Tan, Edi Brogi, Melissa Murray. Memorial Sloan Kettering Cancer Center, NY, NY; Singapore General Hospital, Outram Road, Singapore; Netherlands Cancer Institute, Amsterdam, Netherlands. 35 Genomic Alterations in Breast Fibroadenomas and Phyllodes Tumors Preliminary Findings from the International Fibroepithelial Consortium (278) Puay Hoon Tan, Nur Diyana Binte Md Nasir, Cedric Ng, Rajasegaran Vikneswari, JingQuan Lim, Aye Aye Thike, Bin Tean Teh, International Fibroepithelial Consortium. Singapore General Hospital, Singapore, Serbia; National Cancer Centre, Singapore, Singapore. 36 Massively Parallel Sequencing Analysis of Myxoid Fibroadenomas Reveals a Genomic Landscape Distinct from That of Conventional Fibroadenomas (220) John R Lozada, Fresia Pareja, Kathleen A Burke, Aoife Maguire, Melissa Murray, Edi Brogi, Britta Weigelt, Jorge Reis-Filho, Felipe Geyer. Memorial Sloan Kettering Cancer Center, New York, NY. 37 Morphological and Genomic Heterogeneity in a Malignant Phyllodes Tumor (277) Benjamin Yongcheng Tan, Cedric Chuan Young Ng, Nur Diyana Binte Md Nasir, Vikneswari Rajasegaran, Aye Aye Thike, Bin Tean Teh, Puay Hoon Tan. Singapore General Hospital, Singapore, Singapore; National Cancer Centre, Singapore, Singapore. 38 Low Frequency of HER2-Positive Male Breast Cancers (269) Mohammadreza Shervinrad, Ugur Ozerdem, Fattaneh Tavassoli. Yale University School of Medicine, New Haven, CT. 39 IgG4-Related Sclerosing Disease of the Breast in a Male Patient (293) Taisia Vitkovski, Galina S Marder, Dominic A Filardi, Ekta Gupta, Frank Breuer. Northwell Health, Lake Success, NY; Northwell Health, Great Neck, NY; Northwell Health, Manhasset, NY. 40 Abnormal Loss of c-kit Is Associated with Malignant Transformation in Mammary Epithelium and May Be a Consequence of KIT Promoter Methylation (294) Monika Vyas, Radoslav Janostiak, Ali Cicek, Narendra Wajapeyee, Malini Harigopal. Yale School of Medicine, New Haven, CT. 41 Loss of XIST The Potential Breast Cancer X Factor (118) Anna Biernacka, Vikram Deshpande, Elena Brachtel. Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. 42 Lymph Node Metastasis Is Not Predictive of Overall Survival, Disease Free Survival, or Metastasis in Estrogen Receptor-Positive/Her2-Negative Breast Cancer (218) Suzanna J Logan, Ceyda Sonmez, Chao Zhang, Cameron Neely, Pia Mendoza, Cletus Arciero, Yuan Liu, Xiaoxian Li. Emory, Atlanta, GA; Georgia State, Atlanta, GA. 43 Clinicopathologic Characteristics and Survival Outcomes of Small Size Breast Carcinoma with Metastasis (221) Zhichun Lu, Nilesh S Gupta, Dhananjay Chitale. Henry Ford Hospital, Detroit, MI. 44 Metastatic and Hematolymphoid Neoplasms Involving the Breast: 20 Year Experience at a Large Tertiary Center (234) Kristen E Muller, Julie M Jorns. University of Michigan, Ann Arbor, MI. 169

230 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 45 Prognostic Markers Are Relatively Stable Between Primary Breast Carcinoma and Metastatic Sites: A Retrospective Study (265) Sasan Setoodeh, Elena Lucas, Sunati Sahoo. UT Southwestern Medical Center, Dallas, TX. 46 Prognostic Outcomes in Advanced Breast Cancer (BC): The Metastasis-Free Interval (MFI) Is Important (268) Tiansheng Shen, Gene P Siegal, Shi Wei. University of Alabama at Birmingham, Birmingham, AL. CARDIOVASCULAR PATHOLOGY 47 Assessment of the ISHLT Antibody-Mediated Rejection Grading System for Cardiac Transplantation and Association with Donor Specific Antibodies and Endothelial Activation (319) Aivi Nguyen, Stephanie Dean, Renee Frank, Maria Molina, Malek Kamoun, Priti Lal. Hospital of the University of Pennsylvania, Philadelphia, PA. 48 PSEN1 as an Adjunct for Diagnosis of Human Myocarditis (316) Paul J Hanson, Erika L Jang, Harpreet Rai, Angela Y Chang, Angela Y Mo, Bruce M McManus, Michael A Seidman. University of British Columbia, Vancouver, BC, Canada; Providence Health Care, Vancouver, BC, Canada. 49 Characterizing the Histopathology of Immune Checkpoint Inhibitor Blockade Induced Myocarditis (315) Carolyn H Glass, Richard N Mitchell, Robert Padera, Javid Moslehi, Andrew H Lichtman. Brigham and Women s Hospital, Boston, MA; Vanderbilt University Medical Center, Nashville, TN. 50 Early Aortic Valve Pathology as a Precursor to Clinical Stenosis (323) Maria E Romero, Elena R Ladich, Sho Torii, Robert Kutys, James Atkinson, Frank Kolodgie, Renu Virmani. CVPath Institute, Gaithersburg, MD; Vanderbild University Medical Center, Nashville, TN. 51 The Role of IgG4 in Acquired Aortic Valve Stenosis: A Study of 110 Consecutive Surgical Resected Aortic Valves (309) Melanie Bois, Ahmed U Fayyaz, William D Edwards, Joseph J Maleszewski. Mayo Clinic, Rochester, MN. 52 Xenoimmune Response Can Elicit Early Postoperative Bioprothetic Valve Degeneration (317) Kishio Kuroda, Kenji Kuwaki, Kenta Uto, Saeko Yoshizawa, Takuo Hayashi, Toshio Nishikawa, Atsushi Amano, Takashi Yao. Juntendo University, Tokyo, Japan; Juntedo University, Tokyo, Japan; Tokyo Women s medical university, Tokyo, Japan. 53 Molecular Genetics of Left Ventricular Noncompaction Cardiomyopathy (318) Vidhya Nair, Linda Kocovski, Guillaume Paré. McMaster University, Hamilton, ON, Canada. 54 Arrhythmogenic Cardiomyopathy: A Genotype- Phenotype Correlation of 15 Cases (311) Melanie Bois, Michelle L Kluge, Katrina E Kotzer, Laura J Train, Joseph J Maleszewski. Mayo Clinic, Rochester, MN. 55 Histopathologic and Immunohistochemical Features of Cardiac Myxoma: Review of 28 Cases at a Cardiac Center in Eight Years (328) Ya Xu, Bettye Cox, Mary R Schwartz, Alberto Ayala, Jae Ro. Baylor College of Medicine, Houston, TX; Houston Methodist Hospital, Houston, TX. 56 Small Vessel and Soft Tissue Histology in End-Stage Renal Disease: Specificity of Diagnostic Criteria for Calciphylaxis (313) Carla Ellis, William C O Neill. Emory University, Atlanta, Georgia; Emory University, Atlanta, GA. 57 CD10 Expression in Endothelial Cells of Intramuscular Angioma/Vascular Malformation (324) Toyohiro Tada, Katsutoshi Miura. Toyokawa City Hospital, Toyokawa, Japan; Hamamatsu University School of Medicine, Hamamatsu, Japan. 58 Cardiac Iron Overload Following Liver Transplantation in Patients without Hemochromatosis (320) Stavroula Papadodima, Ricard Masia, James R Stone. National and Kapodistrian University of Athens, Athens, Greece; Massachusetts General Hospital, Harvard Medical School, Boston, MA. 59 Sudden Coronary Death in the Young: Evidence of a Contractile Phenotype of Smooth Muscle Cells in the Atherosclerotic Plaque (321) Stefania Rizzo, Matteo Coen, Antonija Sakic, Gaetano Thiene, Giulio Gabbiani, Cristina Basso, Marie-Luce Bochaton-Piallat. University of Padua, Padova, Italy; University of Geneva, Geneva, Switzerland. 60 Atherosclerotic Plaque Instability in Juvenile Sudden Coronary Death (322) Stefania Rizzo, Gaetano Thiene, Cristina Basso. Cardiovascular Pathology, Padova, Italy. 61 Incidence of Psychiatric Illnesses in Sudden Cardiac Deaths (327) Joseph Westaby, Chandroth Navin Pankajakshan, Mary N Sheppard. St George s University of London, London, United Kingdom. 170

231 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 ENDOCRINE PATHOLOGY 62 Outcome of Large Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) (615) Bin Xu, Giovanni Tallini, Benjamin Roman, R Michael Tuttle, Ronald Ghossein. Sunnybrook Health Science Centre, Toronto, ON, Canada; Bologna University School of Medicine, Bologna, Italy; Memorial Sloan Kettering Cancer center, New York, NY. 63 Clinicopathologic Features of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Features (NIFTP) with Imaging and Molecular Data: The Weill Cornell Medicine Experience (576) Isabelle H Cui, Rema A Rao, Theresa Scognamiglio. New York Presbyterian-Weill Cornell Medicine, New York, NY. 64 Benign-Appearing Thyroid Follicles in Cervical Lymph Nodes from Patients with Papillary Thyroid Microcarcinomas: A Histologic and Immunohistochemical/Molecular Study (571) Qing Chang, Ying Liu, David Hiltzik, Fang-Ming Deng, Xiaowei Chen, Diane Hamele-Bena, Guo-Xia Tong. Staten Island University Hospital, NY, NY; New York University School of Medicine, NY, NY; Columbia University Medical Center, NY, NY. 65 Thyroid Rests or PTC: Can Mutational or NGS Fusion Analysis Help Differentiation? (609) Sean Trevathan, Arundhati Rao. Baylor Scott and White, Temple, TX. 66 Malpractice Climate Is Predictive of Thyroid Cancer Incidence (612) Joshua I Warrick, Brandon Labarge, Vonn Walter, Nicole C Williams, Darrin Bann, David Goldenberg, Henry Crist. Penn State University College of Medicine, Hershey, PA. 67 Pediatric Follicular Thyroid Carcinoma Indolent Behaviour and Low Prevalence of RAS Mutations (610) Huy G Vuong, Tetsuo Kondo, Naoki Oishi, Tadao Nakazawa, Kunio Mochizuki, Akira Miyauchi, Mitsuyoshi Hirokawa, Ryohei Katoh. University of Yamanashi, Chuo, Yamanashi, Japan; Kuma Hospital, Chuo-ku, Kobe, Japan. 68 Pediatric Poorly Differentiated Thyroid Carcinoma: A Clinicopathologic Study (569) Barina Aqil, Mitra Mehrad, Rebecca Chernock. Washington University School of Medicine, St Louis, MO; Vanderbilt University Medical Center, Nashville, TN. 69 Neuroendocrine Site of Origin Immunohistochemistry in Medullary Thyroid Carcinoma (585) Ian J Kidder, Andrew M Bellizzi, Marina Ivanovic. University of Iowa, Iowa City, IA. 70 Diagnostic Utility of FoxA1 in Medullary Thyroid Carcinomas (597) Daisuke Nonaka. The Christie Hospital, Manchester, United Kingdom; The University of Manchester, Manchester, United Kingdom. 71 Mixed Adenoma-Well Differentiated Neuroendocrine Tumors (MANETs) of the Colon. Clinico-Pathologic and Molecular Analysis of 6 Cases of a Rare and Recently Recognized Entity (570) Massimo Bongiovanni, Francesca Molinari, Silvia Uccella, Antonella Savio, Fausto Sessa, Stefano La Rosa. Institute of Pathology, Lausanne, Switzerland; Institute of Pathology, Locarno, Switzerland; University of Insubria, Varese, Italy; Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Jamaica. 72 Ki67 Alone Is the Best Prognostic Predictor in Pancreatic NENs, Irrespective of Their Size (594) Massimo Milione, Patrick Maisonneuve, Alessio Pellegrinelli, Giovanni Centonze, Jorgelina Coppa, Mauro Scotti, Gabriele Del Conte, Vincenzo Mazzaferro. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Milan, Italy; European Institute of Oncology (IEO), Milan, Italy. 73 Microenviroment Features Drive the Prognosis of G3 GEP-NENs (595) Massimo Milione, Rosalba Miceli, Alessio Pellegrinelli, Giovanni Centonze, Francesco Barretta, Sara Pusceddu, Luca Giacomelli, Vincenzo Mazzaferro, Jorgelina Coppa, Gabriella Sozzi, De Braud Filippo, Andrea Anichini. IRCCS Foundation, Istituto Nazionale dei Tumori, Milan, Italy; University of Genova, Genova, Italy. 74 A French Multicentric Retrospective Clinicopathological Study of 43 Oncocytic Adrenal Tumors (601) Karine Renaudin, Sarra Smati-Grangeon, Abir Al Ghuzlan, Sebastien Aubert, Emmanuelle Leteurtre, Martine Patey, Mathilde Sibony, Nathalie Sturm, Frederique Tissier, Eric Mirallie, Rossella Libe, Eric Baudin, Jerome Bertherat, Delphine Drui. CHU Hotel Dieu, Nantes, France; CHU HGRL, Nantes, France; IGR, Villejuif, France; CHU, Lille, France; CHU Robert Debre, Reims, France; Cochin Hospital, Paris, France; Albert Michallon Hospital, Grenoble, France; Pitie Salpetriere Hospital, Paris, France. 75 Both Anterior Pituitary Hormone-Negative and Transcription Factor-Negative Pituitary Adenomas ( True Null Cell Adenomas) (617) Toyoki Yoshimoto, Naoko Inoshita, Junko Takahashi- Fujigasaki, Noriaki Fukuhara, Hiroshi Nishioka, Shozo Yamada. Toranomon Hospital, Minato-ku, Tokyo, Japan; Okinaka Memorial Institute for Medical Research, Minato-ku, Tokyo, Japan; Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan. 171

232 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 76 Pituitary Adenoma Immunohistochemical Characterization: Refining an Algorithm (593) William McDonald, Nilanjana Banerji, Kelsey McDonald, Bridget Ho. Allina Health Laboratories, Minneapolis, MN; Allina Health, Minneapolis, MN; Macalester College, Saint Paul, MN. 77 Actionable Genetic Mutations Are Rare in Pituitary Carcinomas and Atypical Pituitary Adenomas (619) Ranran Zhang, Jason N Rosenbaum, Darya Buehler, M S Salamat, Molly Accola, William Rehrauer, Ricardo V Lloyd. University of Wisconsin School of Medicine and Public Health, Madison, WI. 78 The Flip Side of NIFTP: An Increase in Rates of Unfavorable Histologic Parameters in the Remainder of Papillary Thyroid Carcinomas (614) Kristine S Wong, Kyle C Strickland, Edmund S Cibas, Jeffrey F Krane, Erik K Alexander, Justine A Barletta. Brigham and Women s Hospital, Boston, MA. 83 Evaluation of the Lower Histologic Threshold for Gastric Graft versus Host Disease (753) Mohamed Mostafa, Christopher Hartley, Catherine Hagen. MCW, Milwaukee, WI; University of Wisconsin, Madison, WI. 84 Expression of Immuoregulators IDO1, and PD-L1 in Gastrointestinal Stromal Tumors (747) Andres Matoso, Ayesha Siddique, Kara A Lombardo, Murray B Resnick, Ross Taliano, Li J Wang. Brown University, Providence, RI. 85 Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract (803) Sophia M Shaddy, Michael A Arnold, Konstantin Shilo, Wendy L Frankel, Alan Harzman, Peter Stanich, Martha Yearsley, Christina A Arnold. The Ohio State University Wexner Medical Center, Columbus, OH; Nationwide Children s Hospital, Columbus, OH. GASTROINTESTINAL PATHOLOGY 79 Hydrophilic Polymer Associated Ischemic Enterocolitis (655) Jesus A Chavez, Wei Chen, Wendy L Frankel, Christina A Arnold. The Ohio State University, Columbus, OH. 80 HER2 Driven Colorectal Cancer: A Comprehensive Genomic Profiling Study (790) Jeffrey Ross, Siraj M Ali, Julia A Elvin, Alexa Schrock, James Suh, Jo-Anne Vergilio, Shakti H Ramkissoon, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Laurie M Gay. Albany Med Col, Albany, NY; Foundation Med, Cambridge, NY. 81 Clinical Manifestations of Pathologic Site-Based Classification of Ampullary Carcinomas (ACs): An Analysis of 107 Resected ACs Demonstrates Distinct Clinicopathologic Associations (756) Takashi Muraki, Michelle D Reid, Steven Keilin, Serdar Balci, Nobuyuki Ohike, Takuma Tajiri, Yue Xue, Bahar Memis, Aarti Sekhar, Pardeep Mittal, Alyssa Krasinskas, David Kooby, Shishir Maithel, Juan M Sarmiento, Volkan Adsay. Emory Uni., Atlanta, GA. 82 Tubulovillous Adenomas with Serrated Features Are Associated with a Higher Risk of Advanced Neoplasia on Follow-Up (752) Mohamed Mostafa, Christopher Hartley, Catherine Hagen. Medical College of Wisconsin, Milwaukee, WI; University of Wisconsin Hospital and Clinics, Madison, WI. 86 Rapid Progression to High-Grade Dysplasia or Adenocarcinoma in Barrett s Esophagus Is Associated with Prevalent or Missed Neoplasia at Index Endoscopy (667) Aaron J Cohen, Amitabh Srivastava. Brigham and Women s Hospital, Boston, MA. 87 Ambiguous Adenoma Reporting Leads to Worse Patient Outcomes (670) Daniel N Dang, Suntrea TG Hammer. UT Southwestern, Dallas, TX. 88 Dysplasia in Sessile Serrated Polyps Is Frequently Encountered in Patients Meeting Serrated Polyposis WHO Diagnostic Criteria (653) Romulo Celli, Joanna Gibson. Yale Medical School, New Haven, CT. 89 ERBB2 Alterations a New Prognostic Biomarker in Stage III Colon Cancer (CC) from a FOLFOX Based Adjuvant Trial (PETACC8) (779) Frederique Penault-Llorca, Pierre Laurent-Puig, Anne Cayre, Karine Le Malicot, Jean-Francois Emile, Julien Taieb. Centre Jean Perrin, Clermont Ferrand, France; Hôpital Européen Georges Pompidou, Paris, France; Fédération Francophone de Cancérologie Digestive (FFCD, Dijon, France; Hopital Ambroise Paré, Boulogne, France; Hopital European George Pompidou, Paris, France. 90 Histopathologic Changes in the Gastrointestinal Tract During Anti-Tumor Necrosis Factor-α Therapy (701) Danielle Hutchings, Lysandra Voltaggio. Johns Hopkins School of Medicine, Baltimore, MD. 91 Expect the Unexpected: Gastrointestinal Microsatellite Instable Adenocarcinoma without Characteristic Histopathological Features (816) Sarah C Thomas, Sherma Zibadi, Kun Jiang. Unviersity of South Florida, Tampa, FL; Moffitt Cancer Center, Tampa, FL. 172

233 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 92 Association of Micropapillary Architecture and High Tumor Budding with Prognosis in Patients with Stage III Colon Cancer from a FOLFOX-Based Adjuvant Chemotherapy Trial: NCCTG N0147 (Alliance) (722) Hee Eun Lee, Qian Shi, Nathan R Foster, Emily Chan, Sharlene Gill, Morton Kahlenberg, Suresh Nair, Anthony Shields, Richard M Goldberg, Steven R Alberts, Frank A Sinicrope, Thomas Smyrk. Mayo Clinic, Rochester, MN; The Ohio State University Comprehensive Cancer Center, Columbus, OH; Vanderbilt University School of Medicine, Nashville, TN; BCCA-Vancouver Cancer Centre, Vancouver, Canada; Surgical Oncology Associates of South Texas, San Antonio, TX; Lehigh Valley Health Network, Allentown, PA; Wayne State University, Karmanos Cancer Institute, Detroit, MI. 93 Microscopic Tumor Deposits in the Liver Are Frequently Present in Patients with Liver Metastases from Digestive Neuroendocrine Tumors (686) William Gibson, Raul S Gonzalez, Eric Liu, Chanjuan Shi. Vanderbilt University Medical Center, Nashville, TN. 94 Albumin RNA In Situ Hybridization in Hepatocellular Carcinomas and Other Neoplastic and Non-Neoplastic Tissue: Can This Be a Clinically Useful Marker? (632) Vaidehi Avadhani, Momin T Siddiqui, Diane Lawson, Cynthia Cohen. Emory University, Atlanta, GA. 95 Expression of PD-1 and PD-L1 in High Grade Neuroendocrine Carcinomas of the Gastrointestinal Tract and Associated Host Immune Cells: A Potential Target for Anti-PD-1/PD-L1 Therapy (786) Jordan A Roberts, Raul S Gonzalez, Chanjuan Shi. Vanderbilt University Medical Center, Nashville, TN; University of Rochester Medical Center, Rochester, NY. 96 Russell Body Gastritis: A Multicenter Retrospective Case Series with Literature Review (695) Richard A Hickman, Azore-Dee Bradshaw, Abul Ala Syed Rifat Mannan, Antonio G Neto, Susan Kornacki, Cristina Hajdu, Neil Theise, Jonathan Melamed. NYU Langone Medical Center, New York, NY; Mount Sinai Hospital, New York, NY. 97 Unique Differential Expression of PD-L1 in Anal Squamous Cell Dysplasia and Invasive Carcinoma (635) Andrew Bandy, Xiaoming You, Haonan Li, Jie Liao, Sambasiva Rao, Guang-Yu Yang. Northwestern University, Chicago, IL. 98 Using Pathology Reports to Assess the Endoscopist s Catch and Pathologist s Call in a Series of 11,456 Large Bowel Polyp Specimens with a Focus on Serrated Polyps (760) Asghar Naqvi, Jennifer M Dmetrichuk, Michael Bonert. McMaster University, Hamilton, ON, Canada. 99 Loss of MAdCAM-1 Expression in Colorectal Adenocarcinoma (676) Kelly Devereaux, Adam Gomez, Sushama Varma, Reetesh Pai, Nir Modiano, Teri Longacre, Rob West, Megan Troxell. Stanford Health Care, Stanford, CA; University of Pittsburgh School of Medicine, Pittsburgh, PA; Oregon Health & Science University, Portland, OR. 100 Assessability of Endoscopic Biopsies of the Proximal Large Intestine for the Changes Diagnostic of Sessile Serrated Polyp/Adenoma (778) Garrison Pease, Curtis R Hall. University of Chicago NorthShore, Evanston, IL. 101 Aneuploidy Detected by DNA Flow Cytometry Using Paraffin-Embedded Tissue Can Serve as Both Diagnostic Marker of Dysplasia and Predictive Marker of Neoplastic Progression in Inflammatory Bowel Disease (817) Jia-Huei Tsai, Peter S Rabinovitch, Thomas Small, Danning Huang, Aras N Mattis, Sanjay Kakar, Won-Tak Choi. UCSF Medical Center, San Francisco, CA; University of Washington, Seattle, WA; SUNY Upstate Medical University, Syracuse, NY. 102 Identification of Unique Mutant Gene Profiles and Morphologic Features in a Large Cohort of BRAF-Mutant Colon Adenocarcinomas Using Next Generation Sequencing Approach (711) Ryan D Jones, David Dittmann, Nike T Beaubier, Juehua Gao, Guang-Yu Yang. Northwestern University, Chicago, IL. 103 Distinguishing Hyperplastic Polyps from Small (<1cm) Sessile Serrated Adenoma/Polyps How Good Are We? (705) Rahul Jawale, John R Goldblum, Daniela Allende, Michael Cruise, Ilyssa Gordon, Walter Henricks, Jennifer Jeung, Keith Lai, James Lapinski, Thomas Plesec, Scott Robertson, Erica Savage, Rocio Lopez, Carol Burke, Deepa T Patil. Cleveland Clinic, Cleveland, OH. 104 PD-L1 Expression in IBD-Associated Colorectal Cancer and Its Relationship to MSI Status, the PI3K Pathway, and HLA-DR Expression (628) Lindsay Alpert, Lindsay Yassan, Christopher Weber, Shu-Yuan Xiao, John Hart, Thomas Krausz, Jeremy Segal, Namrata Setia. University of Chicago, Chicago, IL. 105 Type-1 Gastric Neuroendocrine Tumors; Long-Term Follow-Up and Non-Specific ER and GATA-3 Expression (811) Yaman Tarabishy, Ogechukwu Pearl Eze, Maryam Pezhouh, Lysandra Voltaggio, Elizabeth A Montgomery, Kevin Waters. Johns Hopkins Hospital, Baltimore, MD. 173

234 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall ErbB3 Overexpression Predicts Survival in Primary Colorectal Cancer (643) Alina Bocicariu, Kevin Yi Mi Ren, Ravi Ramjeesingh, Nazik Hammad, James J Biagi, Christopher Nicol, Lois Mulligan, Harriet Feilotter, David Hurlbut, Scott Davey. Queen s University, Kingston, ON, Canada; Dalhousie University, Halifax, NS, Canada. 107 Gastric Pyloric Gland Adenoma: A Multicenter Clinicopathologic Study of 65 Cases (662) Won-Tak Choi, Ian Brown, Tetsuo Ushiku, Masato Yozu, Namrata Setia, Amitabh Srivastava, Melanie Johncilla, Rish K Pai, Masashi Fukayama, Joseph Misdraji, Gregory Y Lauwers. UCSF Medical Center, San Francisco, CA; Envoi Pathology, Kelvin Grove Qld, Australia; University of Tokyo, Tokyo, Japan; Massachusetts General Hospital, Boston, MA; University of Chicago, Chicago, IL; Brigham and Women s Hospital, Boston, MA; Mayo Clinic, Phoenix, AZ. 113 Histology of Colorectal Adenocarcinoma with Double Somatic Mismatch Repair Mutations Is Indistinguishable from Those Caused by Lynch Syndrome (694) Jessica Hemminger, Rachel Pearlman, Sigurdis Haraldsdottir, Deborah Knight, Heather Hampel, Wendy L Frankel. The Ohio State University Wexner Medical Center, Comprehensive Cancer Center, Columbus, OH. 114 Is Serrated Polyposis a Genetic Condition? (791) Christophe Rosty, Mark Clendenning, Steven Gallinger, Mark Jenkins, Kevin Sweet, Finlay Macrae, Ingrid Winship, Susan Parry, Daniel Buchanan. Envoi Pathology, Brisbane, Australia; University of Melbourne, Melbourne, Australia; University of Toronto, Toronto, Canada; Ohio State University Medical Centre, Colombus, OH; New Zealand Familial Gastrointestinal Cancer Service, Auckland, New Zealand. 108 EBV and Microsatellite Instability Can Occur in a Subset of Lymphocyte-Rich Intrahepatic Cholangiocarcinomas (754) Taofic Mounajjed, Hee Eun Lee, Tsung-Teh Wu. Mayo Clinic, Rochester, MN. 109 Gastric Type (Pyloric/Foveolar Gland) Adenomas of the Duodenum: A Clinicopathologic Analysis of 11 Cases (714) Juliana O Kissiedu, Bahar Memis, Takashi Muraki, Alyssa Krasinskas, Michelle D Reid, Yue Xue, Volkan Adsay. Emory Uni, Atlanta, GA. 110 Isolated Intestinal Metaplasia in Gastric Antrum (821) Kai Wang, Lei Zhao. University of Alabama at Birmingham, Birmingham, AL. 111 Nuclear Exporter Protein CRM1/XPO1 a Novel Prognostic and Therapeutic Target in Gastric Cancer (739) Zaid Mahdi, Rahman Chaudhary, Irfana Muqbil, Amro Aboukameel, Ramzi Mohammad, Philip Philip, William Senapedis, Rafic Beydoun, Asfar Azmi. Wayne State University, School of Medicine, Detroit Medical Center, Detroit, MI; Wayne State University, School of Medicine, Detroit, MI; Karyopharm Therapeutics, Newton, MA. 115 PD-L1 and PD-1 Expression Profile Depending on the Microsatellite Status and the Histological Subtype in Colorectal Carcinomas (646) Céline Bossard, Eva Ott, Delphine Dansette, Adrien Ouairy, Anne Jarry, Stéphane Bezieau, Claire Toquet, Jean-François Mosnier. CHU Hôtel Dieu, Nantes, France; Faculté de Médecine, Nantes, France. 116 Invasive Carcinomas of the Ampulla with Deceptively Bland Patterns: An Analysis of 35 Cases (671) Drew Davis, Yue Xue, Michelle D Reid, Bahar Memis, Alyssa Krasinskas, Volkan Adsay. Emory University School of Medicine, Atlanta, GA. 117 RICTOR Overexpression/Amplification in Advanced Solid Tumors; a Correlation Study Utilizing Immunohistochemistry, Fluorescence In Situ Hybridization, and Targeted Sequencing (636) Heejin Bang, Soomin Ahn, Jeeyun Lee, Seung Tae Kim, Michael Van Vrancken, Ha Young Park, Kyoung-Mee Kim. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Ewha Womans University School of Medicine, Seoul, Korea; Tulane University School of Medicine, New Orleans, LA; College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea. 112 The Frequency and Patterns of MMR Protein-Deficient Tumors in the Transplant Population (766) Nkechi Okonkwo, William Twaddell. University of Maryland, Baltimore, MD. 174

235 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Assessing and Reporting Tumor Budding in Colorectal Cancer: Recommendations Based on the International Tumor Budding Consensus Conference (ITBCC 2016) (672) Heather Dawson, Alessandro Lugli, Richard Kirsch, Inti Zlobec, Robert H Riddell, Gieri Cathomas, Fred Bosman, Philip Quirke. Institute of Pathology, University of Bern, Bern, Switzerland; University of Toronto, Toronto, Canada; Institute of Pathology, Kantonsspital Liestal, Liestal, Switzerland; University Institute of Pathology, Lausanne University Medical Center, Lausanne, Switzerland; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom. 119 Neuroendocrine Neoplasms of the Gallbladder. An Immunohistochemical and Clinicopathologic Analysis of 29 Cases (784) Michelle D Reid, Juan Carlos Roa, Bahar Memis, Takashi Muraki, Juan Carlos Araya, Miguel Villaseca, Hector Losada, Juan M Sarmiento, Gabriel Sica, Volkan Adsay. Emory Uni, Atlanta, GA; Pontificia Uni Católica de Chile, Santiago, Chile; Uni de La Frontera, Temuco, Chile. GENITOURINARY PATHOLOGY 120 Small Cell Carcinoma of the Bladder (SCCB): Role of Multimodality Management and Genomic Predictors of Response (1055) Min Yuen Teo, Xueli Hao, Neil Desai, Semra Olgac, Anuradha Gopalan, Ying-Bei Chen, Samson W Fine, Sahussapont J Sirintrapun, Dean F Bajorin, Jonathan E Rosenberg, Bernard H Bochner, Guido Dalbagni, Barry S Taylor, Michael F Berger, David Solit, Satish K Tickoo, Victor E Reuter, Gopa Iyer, Hikmat Al-Ahmadie. Memorial Sloan Kettering Cancer Center, New York, NY; Virginia Mason Medical Center, Seattle, WA. 121 An Expanded Immunohistochemal Profile of Osteoclast-Rich Undifferentiated Carcinoma of the Urinary Tract (1011) Salvatore Priore, Lauren E Schwartz, Jonathan I Epstein. University of Pennsylvania, Philadelphia, PA; Johns Hopkins University, Baltimore, MD. 122 Clinicopathologic Study of Sarcomatoid Urinary Bladder Carcinoma: A Matched Cohort Analysis of 30 Cases (888) Nooshin K Dashti, Frank Igor, Robert F Tarrel, Stephen A Boorjian, John C Cheville. Mayo Clinic, Rochester, MN. 123 Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma (UC) from Secondary Involvement of the Bladder by Adenocarcinoma of the Breast or Gastrointestinal (GI) Tract (865) Walaa Borhan, Jonathan I Epstein. Johns Hopkins Hospital, Baltimore, MD; Taibah University, Medina, Saudi Arabia. 124 Study of Role of Tumor Associated Macrophages and Tumor Infiltrating Dendritic Cells as Predictors of Response to BCG Immunotherapy in Non Muscle Invasive Papillary Urothelial Carcinoma (898) Saba El-Gendi, Amal Rahmy, Mohamed Adel Atta, Heba Farid. Faculty of Medicine, Alexandria, Egypt. 125 Programmed Death-Ligand 1 (PD-L1) Expression in Upper Tract Urothelial Carcinoma (1049) Stephanie Skala, Tzu-Ying Liu, Aaron M Udager, Alon Z Weizer, Jeffrey S Montgomery, Ganesh S Palapattu, Javed Siddiqui, Xuhong Cao, Kristina Fields, Ahmed E Abugharib, Moaaz Soliman, Khaled S Hafez, David Miller, Cheryl T Lee, Ajjai Alva, Arul M Chinnaiyan, Todd M Morgan, Daniel E Spratt, Hui Jiang, Rohit Mehra. University of Michigan, Ann Arbor, MI. 126 Molecular Tumour Grading and Classification of Non Muscle Invasive Bladder Cancer Based on Whole Transcriptome Analysis (1070) Theodorus van der Kwast, Alexandre R Zlotta, Jess Shen, Iryna Shnitsar, Aidan P Noon, Eduardo A Cabeza, Haiyan Jiang, Cynthia Kuk, Ruoyu Ni, Balram Sukhu, Kin Chan, Annette Erlich, Morgan Roupret, Thomas Seisen, Eva Comperat, Joan Sweet, Girish S Kulkarni, Neil E Fleshner, Azar Azad, Jeffrey L Wrana. University Health Network, Toronto, ON, Canada; Mount Sinai Hospital, Toronto, ON, Canada; University of Sheffield, Sheffield, United Kingdom; Groupe Hospitalier La Pitié-Salpêtière, Université Pierre et Marie Curie, Paris, France; University of Toronto, Toronto, ON, Canada. 127 Tert Promoter Mutation Status in PUNLMP of the Urinary Bladder (1018) Maria Del Carmen Rodriguez Pena, Aline C Tregnago, Marie-Lisa Eich, Simeon Springer, Yuxuan Wang, Diana Taheri, Dilek Ertoy, Kazutoshi Fujita, Stephania M Bezerra, Isabela W Cunha, Trinity J Bivalacqua, Nickolas Papadopoulos, Ken Kinzler, Bert Vogelstein, George J Netto. Johns Hopkins University, Baltimore, MD; Hacettepe University, Ankara, Turkey; Osaka University, Osaka, Japan; AC Camargo Cancer Center, Sao Paulo, Brazil. 128 Immunohistochemical Assessment of Basal and Luminal Markers in Non-Muscle Invasive Urothelial Carcinoma of Bladder (NMIBC) (1019) Maria Del Carmen Rodriguez Pena, Aline C Tregnago, Alcides Chaux, Diana Taheri, Walaa Borhan, Marie-Lisa Eich, Hirofumi Nonogaki, Rajni Sharma, M Katayoon Rezaei, George J Netto. Johns Hopkins University, Baltimore, MD; Universidad del Norte, Asuncion, Paraguay; George Washington University, Washington, DC. 175

236 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Immunohistochemical Characterization of Basal and Luminal Phenotypes in Muscle Invasive Bladder Urothelial Carcinomas (MIBC) Treated with Neoadjuvant Chemotherapy (NAC) (1060) Aline C Tregnago, Maria Del Carmen Rodriguez Pena, Marie-Lisa Eich, Diana Taheri, Hirofumi Nonogaki, Rajni Sharma, David McConkey, Trinity J Bivalacqua, George J Netto, Alexander Baras. Johns Hopkins University, Baltimore, MD. 130 Utility of Immunohistochemistry for Classification into Luminal and Basal Urothelial Bladder Carcinoma and Clinical Significance (1047) Carolina Silva Morera, Anna Scavuzzo, Miguel Angel Jimenez, Guadalupe Moncada, David Cantu de Leon, Lourdes Pena, Julia Mendoza Perez, Delia Perez Montiel. Instituto Nacional de Cancerologia, Mexico City, Mexico. 131 Squamous Cell Carcinoma (SqCC) of the Urinary Bladder: A Clinicopathologic and Molecular Study with PD-L1 Immunohistochemistry (IHC) Correlation (1069) Aaron Udager, Daniel H Hovelson, Andrew S McDaniel, Simpa S Salami, Javed Siddiqui, Xuhong Cao, Daniel E Spratt, Ganesh S Palapattu, Alon Z Weizer, Khaled S Hafez, Jeffrey S Montgomery, Arul M Chinnaiyan, Ajjai Alva, Scott A Tomlins, Rohit Mehra. University of Michigan Health System, Ann Arbor, MI. 132 Comparative Analysis of Histopathology Assessment Criteria to Predict Progression in PT1 Bladder Cancer (960) Mariah Z Leivo, Debashis Sahoo, Leili Mirsadraei, Donna Hansel. University of California at San Diego, La Jolla, CA. 133 Pathologic Prognostic Factors in Radical Cystectomy Post-Neodjuvant Chemotherapy (867) Fadi Brimo, Kiril Trpkov, Daniel Athanazio, Asli Yilmaz, Michelle Downes, Elan Hahn, Shraddha Solanki, Tamara Jamaspishvili, Wassim Kassouf, David Berman. McGill University Health Center, Montreal, QC, Canada; Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada; Sunnybrook Health Sciences Center, Toronto, ON, Canada; Queen s University, Kingston, ON, Canada. 134 Pathologic Features and Long Term Clinical Follow Up of Treatment-Naïve Non Invasive Papillary Urothelial Neoplasms of the Urinary Bladder (1037) Judy Sarungbam, Qiang Li, Hikmat Al-Ahmadie, Ying- Bei Chen, Samson W Fine, Sahussapont J Sirintrapun, Anuradha Gopalan, Satish K Tickoo, Guido Dalbagni, Victor E Reuter. MMC, Bronx, NY; MSKCC, NY, NY. 135 Concordance Study of 4 Anti-PD-L1 Antibodies in Primary and Metastatic Bladder Cancer (966) Thomas Long, Regan Fulton, Masha Kocherginsky, Tatjana Antic, Cigdem Ussakli, Allen M Gown, Maria Tretiakova. University of Washington, Seattle, WA; University of Chicago, Chicago, IL; PhenoPath, Seattle, IL. 136 Down-Regulation of Fructose-1, 6-Bisphosphatase-1 (FBP1) in High Grade Urothelial Carcinoma (UC); as a New Diagnostic Marker to Differentiate Nested Variants of Urothelial Carcinoma from Benign Entities (904) Taliya Farooq, Anas Mashlah, Faisal Saeed, Islam Humayun, Jonathan I Epstein, Minghao Zhong. New York Medical College at Westchester Medical Center, Valhalla, NY; Johns Hopkins University, Baltimore, MD. 137 Paraganglioma of the Urinary Bladder: A Pathologic and Clinical Study of 26 Cases (933) Chad J Hruska, Bogdan Czerniak, Charles Guo. UT MD Anderson Cancer Center, Houston, TX. 138 Gynecologic Organ Involvement by Malignancy in Radical Cystectomies (RC) for Urothelial Carcinoma (UC) (978) Cathleen E Matrai, Abimbola Ayangbesan, David M Golombos, Brian Robinson, Douglas S Scherr, Francesca Khani. Weill Cornell Medicine, NYC, NY. 139 The Utility of AMACR as a Diagnostic Marker for Urothelial Carcinoma In Situ, a Study Supported by Morphometric Image Analysis and Triple Immunohistochemical Panel [CK 20, CD44 and p53] (945) Nora N Kamel, Zahraa S Elalfy, Shady E Anis, AbdelRazik H Farrag, Wafaa E Abdel-Aal, Samira AM Salem, Elia A Ishak. National Research Centre, Giza, Egypt; cairo university, cairo, Egypt. 140 Clinicopathologic and Molecular Characterization of a Cohort of Urobasal and Nonbasal Subtypes of High- Grade Urothelial Carcinomas (HGUCa) (986) Sambit K Mohanty, Shivani Sharma, Matthew Geller, Nitin Bhardwaj, Jasreman Dhillon. CORE Diagnostics, Gurgaon, India; Winthrop University Hospital, Mineola, NY; Moffitt Cancer Center, Tampa, FL. 141 Programmed Death-Ligand 1 Expression Correlates with No Downstaging After Platinum Therapy in Muscle-Invasive Bladder Cancer (1020) Shira Ronen, Christopher Hartley, Kenneth Iczkowski. Medical College of Wisconsin, Milwaukee, WI. 142 Interobserver Reproducibility of the Paris System for Reporting Urinary Cytology (958) Lester Layfield, Theresa Long, Robert L Schmidt, Magda Esebua, Shellaine R Frazier, Tamar Giorgadze. University of Missouri, Columbia, MO; University of Utah and ARUP Laboratories, Salt Lake City, UT; Weill Cornell Medicine, New York, NY. 176

237 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Molecular Characterization of High Grade Neuroendocrine Carcinoma of the Urinary Bladder (923) Sounak Gupta, Loren P Herrera Hernandez, Donna Hansel, Sarah H Johnson, Rafael E Jimenez, Farhad Kosari, John C Cheville. Mayo Clinic, Rochester, MN; UCSD, La Jolla, CA. 144 The Relationship Between Tobacco Smoking and Clinicopathologic Features of Bladder Urothelial Carcinoma with Emphasis on Variant Histology (1083) Jianmin Xu, Giovanna Giannico, Peter E Clark, Omar Hameed, Lan L Gellert. Vanderbilt University Medical Center, Nashville, TN. 145 Sarcomatoid Carcinoma Associated with Small Cell Carcinoma of the Urinary Bladder (1013) Yuly Ramirez, Jonathan I Epstein. Johns Hopkins Hospital, Baltimore, MD. 146 Pseudosarcomatous Myofibroblastic Proliferations of the Urinary Bladder Lack the USP6 Gene Rearrangement Common in Nodular Fasciitis (943) Judith AS Jebastin, Nilesh S Gupta, Shannon Carskadon, Nallasivam Palanisamy, Sean R Williamson. Henry Ford Health System, Detroit, MI. 147 Urothelial Carcinoma with Loss of MSH2 and/or MSH6 Expression: A Clinicopathologic Study of 11 Cases (962) Li Liang, Priya Rao. The University of Texas MD Anderson Cancer Center, Houston, TX. 148 Lymphoepithelioma-Like Carcinoma of the Bladder: Analysis of Mismatch Repair Proteins and PD-L1 by Immunohistochemistry (866) Cori Breslauer, William Kim, Jonathan I Epstein, Sara E Wobker. University of North Carolina, Chapel Hill, NC; Johns Hopkins Medical Institutions, Baltimore, MD. 149 Cell Polarity Reversal Distinguishes True Micropapillary Growth from Retraction Artifacts in Invasive Urothelial Carcinoma (939) Yiang Hui, Kara A Lombardo, M Ruhul Quddus, Andres Matoso. Warren Alpert Medical School of Brown University, Providence, RI. 150 The Role of SATB2 Immunohistochemistry in the Differential Diagnosis of Malignant Glandular Lesions of the Urinary Bladder (973) Nicholas Mackrides, Merce Jorda, Andre Pinto. University of Miami, Miami, FL. 151 Immunohistochemistry of Sex Hormone Receptors and Related Signals in Bladder Cancer as Predictors of Chemosensitivity (951) Eiji Kashiwagi, Hiroki Ide, Satoshi Inoue, Takashi Kawahara, George J Netto, Alexander Baras, Hiroshi Miyamoto. Johns Hopkins University, Baltimore, MD; University of Rochester, Rochester, NY. 152 Protein Expression and Genomic Alterations of PMS2 in Urothelial Bladder Cancer (994) Sahar Nozad, Mohammed Shiekhmohammed, Bhaskar VS Kallakury, Christine E Sheehan, Julia A Elvin, Jo- Anne Vergilio, James Suh, Shakti H Ramkissoon, Siraj M Ali, Alexa Schrock, Sumanta Pal, Sumanta Pal, Hugh A Fisher, Badar Mian, Tipu Nazeer, David Fabrizio, Garrett Frampton, Caitlin Connelly, Vincent Miller, Philip Stephens, Laurie M Gay, Jeffrey Ross. Albany Med Col, Albany, NY; Georgetown University Hosp, Washington, DC; Foundation Med, Cambridge, MA. 153 Utility of Clinical Risk Stratification in the Selection of Muscle-Invasive Bladder Cancer (MIBC) Patients for Neoadjuvant Chemotherapy (NAC) Prior to Radical Cystectomy (RC): A Retrospective Cohort Study (976) Douglas A Mata, Friedrich-Carl von Rundstedt, Oleksandr N Kryvenko, Anup Shah, Iny Jhun, Seth P Lerner. Brigham and Women s Hospital, Boston, MA; Baylor College of Medicine, Houston, TX; University of Miami Miller School of Medicine, Miami, FL; University of Pittsburgh Medical Center, Pittsburgh, PA. 154 The Impact of Consistent Reporting of the Presence or Absence of Muscularis Propria in Bladder Biopsies at an Academic Center (957) Razvan Lapadat, Eva M Wojcik, Guliz Barkan, Maria Picken, Stefan Pambuccian. Medical College of Wisconsin, Milwaukee, WI; Loyola University Medical Cente, Maywood, IL. 155 High Expression of MAP1B in Urothelial Carcinoma: with Special Attention to Prognostic Impact and Biological Aggressiveness (929) Hong-Lin He, Yow-Ling Shiue, Chien-Feng Li. Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan; E-DA Hospital, I-Shou University, Kaohsiung, Taiwan; Chi Mei Medical Center, Tainan, Taiwan. 156 Programmed Death-1 Expression in Micropapillary Urothelial Carcinoma of the Bladder: Role for Immune Checkpoint Inhibitors (915) Abigail L Goodman, Adeboye O Osunkoya. Emory University Hospital, Atlanta, GA. 177

238 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 GYNECOLOGIC AND OBSTETRIC PATHOLOGY 157 Subsequent Breast and High Grade Serous Carcinomas After Risk-Reducing Salpingo-Oophorectomy in BRCA Mutation Carriers and Patients with History of Breast Cancer (1246) Melissa Straub, Mirna B Podoll, Stephanie N David, Stoudenmire J Charles, Georgia L Wiesner, Mohamed M Desouki. Vanderbilt, Nashville, TN; Vanderbilt-Ingram Cancer Center, Nashville, TN. 158 Intraoperative Evaluation of Prophylactic Hysterectomy and Salpingo-Oophorectomy Specimens in Hereditary Gynecologic Cancer Syndromes (1267) Serena Wong, Natalia Buza. Yale School of Medicine, New Haven, CT. 159 Targeted Genomic Profiling Reveals Recurrent KRAS Mutations and 1q Gain in Mesonephric Carcinoma-Like Adenocarcinomas of the Female Genital Tract (1163) Brooke E Howitt, Marie McFarland, Elizabeth Garcia, Lynette M Sholl, Neal I Lindeman, Laura E MacConaill, Fei Dong, Michelle S Hirsch, Marisa R Nucci, Charles M Quick, Christopher P Crum, W Glenn McCluggage, Jelena Mirkovic. Brigham and Women s Hospital, Boston, MA; Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom; University of Arkansas for Medical Sciences, Little Rock, AR. 160 Targeted Genomic Profiling of Female Adnexal Tumors of Probable Wolffian Origin (1162) Brooke E Howitt, Elizabeth Garcia, Lynette M Sholl, Neal I Lindeman, Laura E MacConaill, Fei Dong, Michelle S Hirsch, Marisa R Nucci, Christopher P Crum, W Glenn McCluggage, Jelena Mirkovic. Brigham and Women s Hospital, Boston, MA; Harvard Medical School, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom. 161 Residual Tubal Carcinoma Following Neoadjuvant Chemotherapy in Advanced Stage Pelvic High Grade Serous Carcinoma: Challenges in Diagnosis and Primary Site Assignment (1122) Emily Chan, Joseph Rabban. UCSF, San Francisco, CA. 162 Immunohistochemical Expression of p53 and WT1 Is Retained Following Chemotherapy in High-Grade Serous Tubo-Ovarian Carcinoma (HGSC) (1151) Raji Ganesan, Naveena Singh, Laura Casey, Simone Tam, Asma Faruqi, Rajeev Prasad, Steffen Boehm, Michelle Lockley, Arjun J Jeyarajah, Blake Gilks, Martin Koebel. Birmingham Womens Hospital NHS Foundation Trust, Birmingham, United Kingdom; Barts Health NHS Trust, London, United Kingdom; Queen s Hospital, Romford, Essex, United Kingdom; Queen Mary University of London, London, United Kingdom; Vancouver General Hospital, Vancouver, BC, Canada; University of Calgary, Calgary, AB, Canada. 163 Poor Inter-Rater Agreement in the Diagnosis of Intra- Epithelial Fallopian Tube Nuclear Atypia (1226) Nicholas P Reder, Nicholas Agoff, Rochelle Garcia, Elizabeth Swisher, Mark R Kilgore. University of Washington Medical Center, Seattle, WA; Virginia Mason Hospital and Medical Center, Seattle, WA. 164 Fallopian Tube Examination: A Potential Strategy to Improve the Accuracy of Intraoperative Primary Site Assignment of Mucinous Tumors Involving the Ovary (1160) Anjelica Hodgson, Sharon Nofech-Mozes, Dina Bassiouny, Fang-I Lu, Matthew Cesari, Nadia Ismiil, Carlos Parra-Herran, Bojana Djordjevic. Sunnybrook Health Sciences Centre University of Toronto, Toronto, ON, Canada. 165 Frozen Section Assessment of Mucinous Neoplasms Involving the Ovary: A Novel Approach Toward a More Accurate Diagnosis (1161) Anjelica Hodgson, Sharon Nofech-Mozes, Dina Bassiouny, Fang-I Lu, Matthew Cesari, Nadia Ismiil, Carlos Parra-Herran, Bojana Djordjevic. Sunnybrook Health Sciences Centre University of Toronto, Toronto, ON, Canada. 166 Central Nervous System-Type Neuroepithelial Tumors in Ovarian Teratomas (1215) Tricia Murdock, Fausto Rodriguez, Brigitte M Ronnett. The Johns Hopkins Institutions, Baltimore, MD. 167 Malignant Transformation Arising in Mature Cystic Teratoma (1237) Palzum Sherpa, Reetu Baral, Trishna Kakshapati. Patan Academy of Health Sciences, Lalitpur, Nepal. 168 Immunohistochemical Assessment of 23 Immature Ovarian Teratomas (1124) Gregory Charville, Teri Longacre, Hannes Vogel, Thomas M Ulbright, Chia-Sui Kao. Stanford University School of Medicine, Stanford, CA; Indiana University School of Medicine, Indianapolis, IN. 169 Mixed Epithelial and Non-Teratomatous Germ Cell Tumors of the Upper Gynecologic Tract (1240) Stephanie Skala, Andrew Sciallis. University of Michigan Health System, Ann Arbor, MI. 178

239 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Ovarian Granulosa Cell Tumors: A Surveillance, Epidemiology and End Results (SEER) Data Review of Prognostic Clinicopathological Parameters in 1815 Patients (1092) Eman Abdulfatah, Marcel T Ghanim, Oumaima Chaib, MHD Fayez Daaboul, Baraa Alosh, Khaleel I Al- Obaidy, Zaid Mahdi, Kinda Hayek, Sharif Sakr, Adnan R Munkarah, Sudeshna Bandyopadhyay, Rouba Ali- Fehmi. Wayne State University School of Medicine, Detroit, MI; Karmanos Cancer Center/Wayne State University, Detroit, MI; Henry Ford Health System, Detroit, MI. 171 Transcript-Based Classification of Omental Implants from Ovarian Borderline Serous Tumor Using a Cancer Gene Panel (1261) Saloni Walia, Guisong Wang, Kate Lawrenson, GLarry Maxwell, Kathleen M Darcy, Iyare Izevbaye, Paulette Mhawech-Fauceglia. University of Southern California, Los Angeles, CA; Inova Fairfax Hospital, Falls Church, VA; Women s Health Integrated Resource Center, Annandale, VA; University of Alberta, Edmonton, AB, Canada. 172 KRAS or BRAF Mutation in Ovarian Low-Grade Serous Carcinoma: An Analysis of 32 Chinese Patients (1111) Rui Bi, Yan Xu, Ling Shan, Yaoxing Xiao, Xiaoyu Tu, Xiaoyan Zhou, Wentao Yang. Fudan University Shanghai Cancer Center, Shanghai, China. 173 Pre-Operative Distinction of HGSC versus LGSC in Women at Initial Presentation with Advanced Stage Pelvic Cancer (1264) Rebecca J Wolsky, Matt A Price, Joseph Rabban. UCSF, San Francisco, CA. 174 Transitional Cell Carcinomas (TCC) and Non-TCC High Grades Serous Carcinomas (HGSC) of the Ovary Share Identical Immunostaining Profiles Using Established HGSC Markers (1201) Jamie Magrill, Stefan Kommoss, David G Huntsman, C Blake Gilks, Dawn R Cochrane, Aline Talhouk, Robert Soslow, Anthony N Karnezis, Basile Tessier-Cloutier, Christine Chow, Angela S Cheng, Andreas du Bois, Jacobus Pfisterer, Friedrich Kommoss. BC Cancer Agency, Vancouver, BC, Canada; Vancouver General Hospital, Vancouver, BC, Canada; Tübingen University Hospital, Tübingen, Germany; Memorial Sloan Kettering Cancer Center, New York, NY; Kliniken Essen Mitte, Essen, Germany; Gynecologic Oncology Center, Kiel, Germany. 175 Quantitative Assessment of the Immune Microenvironment in Ovarian Cancer: A Comparison of Two Digital Image Analysis Platforms (1137) Kai Duan, Ramlogan Sowamber, Trevor McKee, Amit Oza, Stéphanie Lheureux, Blaise Clarke, Patricia Shaw. University Health Network, Toronto, ON, Canada. 176 The Expression of PD-L1, PD-1, and DNA Mismatch Repair Proteins in Clear Cell Carcinoma of the Ovary: A Pilot Assessment of Frequency, Clinicopathologic Significance and Potential Correlations (1143) Oluwole Fadare, Charles M Quick, Katja Gwin, Vinita Parkash. UCSD, San Diego, CA; UAMS, Little Rock, AR; UTSW, Dallas, TX; Yale University, New Haven, CT. 177 Prognostic Significance of PD-1 and PDL-1 Expression in Ovarian Carcinomas and Tumor Associated Immune Cells (1103) Binara Assylbekova, Jose P Leone, Kate Serdy, Xin Li, Kavita R Varma, Esther Elishaev, Beth Z Clark, David J Dabbs, Rohit Bhargava. Magee Womens Hospital of UPMC, Pittsburgh, PA; University of Iowa, Iowa City, IA. 178 Characterization of the Surface Expression of PD-1/PD- L1 Signaling Proteins in High-Grade Serous Ovarian Carcinoma (1275) Ju-Yoon Yoon, Jocelyn M Stewart, Christopher Go, Marcus Bernardini, Blaise Clarke, Patricia Shaw, Benjamin Neel, Laurie Ailles. University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada; NYU-Langone Medical Center, Bronxville, NY. 179 Bilateral High Grade Serous Carcinoma of Ovary: A Targeted Next Generation Sequencing Study (1274) Esther C Yoon, Jian Zhuge, Liying Han, John T Fallon, Minghao Zhong. New York Medical College at Westchester Medical Center, Valhalla, NY. 180 Mismatch Repair Protein Expression in Endometrioid Carcinoma of the Ovary: Incidence and Clinicopathologic Associations in 77 Cases (1110) Jennifer Bennett, Anna Pesci, Jason Badrinarain, Annacarolina Da Silva, Esther Oliva. Lahey Hospital, Burlington, MA; Ospedale Sacro Cuore-Don Calabria, Verona, Italy; Dana Farber Cancer Institute, Boston, MA; Massachusetts General Hospital, Boston, MA. 181 Molecular Profiling and Morphologic Correlation as a Quality Assurance Metric in Epithelial Ovarian Cancer (1185) David Kolin, Tracy Stockley, Suzanne Kamel-Reid, Swati Garg, Amit Oza, Stéphanie Lheureux, Helen MacKay, Marcus Butler, Neesha Dhani, Blaise Clarke, Patricia Shaw. University Health Network, Toronto, ON, Canada. 182 Neoadjuvant Chemotherapy (NAC) in Ovarian High Grade Serous Carcinoma (HGSC): Pathological Response and Morphological Characterization (1199) Francesca Locatelli, Antonio De Leo, Barbara Corti, Nunzio CM Salfi, Anna Myriam Perrone, Claudio Zamagni, Pierandrea De Iaco, Donatella DS Santini. St.Orsola-Malpighi University Hospital, Bologna, Italy. 179

240 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Therapeutic Potential of Anti-CD137 in Ovarian Tumors (1216) Alexander Nobori, Itsushi P Shintaku, Neda A Moatamed. David Geffen School of Medicine at UCLA, Los Angeles, CA. 191 GATA3 in Müllerian Malignancies: A Potential Diagnostic Pitfall (1252) Tatjana Terzic, Sara Zadeh, Kristen Atkins, Krisztina Z Hanley, Anne Mills. University of Virginia, Charlottesville, VA; Emory University, Atlanta, GA. 184 The Utility of Molecular Characterization of Gynecologic Small Blue Round Cell Tumors: Report of Two EWSR1-ERG-Positive Ewing Sarcoma Cases (1213) Nissreen Mohammad, Angela Goytain, Martin Jones, Shangguo Tang, Michael Brennan, Blake Gilks, Janessa Laskin, Tony Ng. University of British Columbia, Vancouver, BC, Canada; Jack Bell Research Centre, Vancouver, BC, Canada; BC Genome Sciences Centre, Vancouver, BC, Canada; McMaster University Medical Centre, Hamilton, ON, Canada; Niagara Health System, St. Catherines General site, ON, Canada; Vancouver General Hospital, Vancouver, BC, Canada; BC Cancer Agency, Vancouver, BC, Canada. 185 SATB2 Is a Useful Marker in Differentiating Metastatic Poorly Differentiated Gastric Carcinomas with Signet Ring Cell Features from Appendiceal Goblet Cell Carcinoids in Ovary (1279) Lingxin Zhang, Chen Yang, Dengfeng Cao. Pathology & Immunology, Saint Louis, MO. 186 The Pathologic Distinction of Primary Mucinous from Metastatic Tumors of the Ovary: A Re-Evaluation of Algorithms Based on Gross Features (1164) Jingjing Hu, Andres A Roma, Vinita Parkash, Oluwole Fadare. UCSD, San Diego, CA; Yale, New Haven, CT. 187 Metastatic Tumors Involving the Ovary: Pathologic Features Associated with Patterns of Clinical Presentation in 68 Cases (1165) Jingjing Hu, Andres A Roma, Vinita Parkash, Oluwole Fadare. UCSD, San Diego, CA; Yale University, New Haven, CT. 188 Incidental Gynecological Tract Neoplasms in Women Undergoing Cystectomy for Urothelial Carcinoma (1255) Lily Tran, Tatjana Antic, Ricardo R Lastra. University of Chicago, Chicago, IL. 189 Umbilical Lesions: A Clinicopathological Review (1235) Shenon Sethi, Smita Patel, Vijaya B Reddy, Pincas Bitterman, Ritu Ghai, Paolo Gattuso. Rush University Medical Center, Chicago, IL. 190 Aberrant PAX8 Expression in Well Differentiated Papillary Mesothelioma and Malignant Mesothelioma (1272) Deyin Xing, Natalie Banet, Peter Illei. Johns Hopkins Medical Institute, Baltimore, MD. 192 Amplification of the NSD3-CHD8-BRD4 Axis in Pelvic High-Grade Serous Carcinomas of Tubo-Ovarian and Endometrial Origin (1173) Derek Jones, Douglas Lin. Beth Israel Deaconess Medical Center, Boston, MA. 193 Clinical Utility of Next Generation Sequencing (NGS) Panel for Recurrent/Advanced Stage Gynecological Malignancies (1196) Diana Lim, Xiao-Wen Lee, Xue-Qing Koh, Brendan Pang, Richie Soong, David SP Tan. National University Health System, Singapore, Singapore; Centre for Translation Research and Diagnostics, Cancer Science Institute, Singapore, Singapore; National University Cancer Institute, Singapore, Singapore. 194 Tumoral and Peritumoral Immune PD-L1 Expression in Ovarian and Endometrial Clear Cell Carcinomas (1263) Brian C Willis, Emily A Sloan, Anne Mills. University of Virginia, Charlottesville, VA. INFORMATICS 195 WSI-FS II: Validation of Squamous Cell Carcinoma Whole Frozen Section Slide Image Diagnosis in Surgical Pathology (1600) Vamsi Parimi, Ryba Dominika, Ewa Borys, Vijayalakshmi Ananthanarayanan, Swati Mehrotra, Xianzhong Ding, Maria M Picken, Dariusz Borys. Loyola University Medical Center, Maywood, IL. 196 Apply a Confocal WSI Scanner for FISH Slides Imaging, 3D Reconstruction, and Semi-Automated Diagnosis (1585) Xiujun Fu, Pinky Bautista, Jochen K Lennerz, Maristela Onozato, Anthony Iafrate, Yukako Yagi. Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. 197 Improving Workflow Efficiency for Special Stains in a Digital Pathology Laboratory (1588) Matthew G Hanna, Liron Pantanowitz, Megan Morrell, Katie Beseler, Jessica Stinner, Jon Duboy, Matthew O Leary, Michael A Nalesnik, Douglas Hartman. UPMC, Pittsburgh, PA. 198 Specimen Tracking Using Two-Dimensional Barcode System for Anatomic Pathology (1602) Anil Parwani, Keluo Yao, Lindsay Thorn, Sandra Banky, Keith Mullins, JoAnna Williams, Adrian Suarez. The Ohio State University Wexner Medical Center, Columbus, OH. 180

241 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall A Large Multicenter, Retrospective Non-Inferiority Study to Evaluate Diagnostic Concordance Between Optical vs Digital Microscopic Diagnoses in 2000 Surgical Pathology Cases (1583) Michael Feldman, Brian P Rubin, Christopher A Moskaluk, Nicolas Cacciabeve, Guy Lindberg, Mischa Nelis, Clive R Taylor. Univ. Pennsylvania, Philadelphia, PA; Cleveland Clinic, Cleveland, OH; Univ. Virginia, Charlottesville, VA; Advanced Pathology Assoc, Rockville, MD; Miraca Life Science, Irving, TX; Philips Digital Pathology Solutions, Best, Netherlands; Univ. Southern California, Los Angeles, CA. 200 Remote Neurosurgery Intraoperative Consultation by Visiontek Live Digital Microscope and Webex (1611) Keluo Yao, David A Kellough, Scott Hammond, Scott L Wade, Lynn Schoenfield, Norman Lehman, Adrian Suarez, Anil Parwani, Jose Otero. The Ohio State University Wexner Medical Center, Columbus, OH. 201 Live Digital Telepathology Enables Rapid Remote Frozen Section Diagnosis and Cytology Adequacy Assessment by Subspecialists (1592) Yehonatan Kane, Farbod Darvishian, Fang-Ming Deng, Andre L Moreira, Aylin Simsir, Christopher William, Matija Snuderl. New York University Medical Center, New York, NY. 206 Computerized Density Estimation of Tumor-Infiltrating Lymphocyte in H&E TMAs Predicts Recurrence in Early Stage Non-Small Cell Lung Cancer (1607) Xiangxue Wang, German Corredor, Eduardo Romero, Andrew Janowczyk, Yu Zhou, Michael C Yang, Vamsidhar Velcheti, Anant Madabhushi. Case Western Reserve University, Cleveland, OH; Universidad Nacional de Colombia, Bogota, Colombia; Cleveland Clinic Foundation, Cleveland, OH. 207 Identifying the Histomorphometric Basis of MRI Radiomic Features in Distinguishing Gleason Grades of Prostate Cancer (1603) Gregory Penzias, Asha Singanamalli, Robin Elliott, Jay Gollamudi, Natalie Shih, Michael Feldman, Phillip D Stricker, Warick Delprado, Sarita Tiwari, Maret Bohm, Ann Maree-Haynes, Lee Ponsky, Pallavi Tiwari, Satish Viswanath, Anant Madabhushi. Case Western Reserve University, Cleveland, OH; University of Pennsylvania, Philadelphia, PA; St. Vincent s Prostate Cancer Clinic, Sydney, NSW, Australia. 208 Histological Characterization of Colorectal Polyps Using Deep-Learning (1599) Andrea Olofson, Saeed Hassanpour, Catherine Nicka, Allen Miraflor, Laura Gordon, Saeed Hassanpour, Arief Suriawinata. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 202 Utilization of Computer-Verified Training Sets in Ki67 Assessment of Neuroendocrine Tumors (1605) Evita Sadimin, Wenjin Chen, Natalie Gilbert, Nicola Barnard, Marina Chekmareva, Michael May, Parisa Javidian, Sumi Thomas, Malik Deen, David Foran. Rutgers Cancer Institute of New Jersey, New Brunswick, NJ; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. 203 Computational Pathology versus Manual Microscopy: Comparison Based on Workflow Simulations of Breast Core Biopsies (1591) Terrell Jones, Luong Nguyen, Akif B Tosun, S C Chennubhotla, Jeffrey L Fine. University of Pittsburgh, Pittsburgh, PA. 204 Redefining the High Power Field When Counting Mitoses Using Digital Pathology (1586) Matthew G Hanna, Liron Pantanowitz. UPMC, Pittsburgh, PA. 205 Area of Interest Analysis of Eye Gaze on Digital Pathology Media (1584) Sharon Fox, Beverly E Faulkner-Jones. Beth Israel Deaconess Medical Center, Boston, MA. 209 A Synoptic Electronic Order Set for Placental Pathology: A Framework Extensible to Non-Neoplastic Pathology (1581) Adela Cimic, S Joseph Sirintrapun. Maimonides Medical Center, Brooklyn, NY; Memorial Sloan Kettering Cancer Center, New York, NY. 210 Advanced Decision Support for Anatomic Pathology Laboratory Information Systems (1589) Douglas Hartman, Michael A Fitzgerald, Anthony L Piccoli, Samuel A Yousem, Liron Pantanowitz. University of Pittsburgh School of Medicine, Pittsburgh, PA. 211 Identification of Cancer Cases Using ICD-9 and ICD-10 Codes in Electronic Health System (1612) Lei Zhang, Javier Sanz, Alexander Stanoyevitch, Robert Follett, Douglas Bell. Anaheim Regional Medical Center, Anaheim, CA; UCLA, Los Angeles, CA; California State University- Dominguez Hills, Carson, CA. 212 The Use of Camtasia Studio 8 with Narrated Virtual Microscopy as a Multimedia Resource for Pathology Education (1593) Priyadarshini Kumar, Xuemo Fan. Cedars Sinai Medical Center, Los Angeles, CA. 213 The Use of Screencasts with Embedded Virtual Microscopy Slides and Videos Describing How to Gross Specimens and Narrated Lectures to Teach Pathology Residents (1608) Mary Wong, Alberto M Marchevsky. Cedars-Sinai Medical Center, Los Angeles, CA. 181

242 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall PathCaseShare: A Web-Based Pathology Case Sharing Platform and Crowd-Sourced Knowledge Base (1606) Jung Hoon Son, Anthony Rubino, Anna Lee, Shane Betman. Columbia University, New York, NY. 215 Creating a Digital Slide Repository: A Novel Educational Tool for Pathology Trainees (1590) Devi Jeyachandran, Brandon Veremis, Abul Ala Syed Rifat Mannan, Pooja Navale, Matthew G Hanna, Tamara Kalir. The Mount Sinai Hospital, New York, NY; University of Pittsburgh School of Medicine, Pittsburgh, PA. 216 WIYDX: A Versatile Interactive Online Platform for Pathology Education (1598) Abul Ala Syed Rifat Mannan, Shyam Prajapati, Emilio Madrigal, Rajendra Singh. Mount Sinai Hospital, New York, NY. KIDNEY/RENAL PATHOLOGY 217 De Novo Immune Complex Deposition in Kidney Allografts (1637) Isaac E Lloyd, Faris Ahmed, Monica P Revelo, Mazdak Khalighi. University of Utah, Salt Lake City, UT. 218 Spectrum of IgA-Associated Glomerular Lesions in Patients with Liver Disease (1621) Vincent M Cracolici, Beth L Braunhut, Anthony Chang, Kammi J Henriksen. University of Chicago Medical Center, Chicago, IL. 219 Disease Association in Collapsing Glomerulopathy (1627) Francois Gougeon, Harsharan K Singh, J Charles Jennette, Volker Nickeleit. UNC-Chapel Hill, Chapel Hill, NC. 220 Complement Activation and ADAMTS13 Suppression May Contribute to the Characteristic Pathological Features in Upshaw-Schulman Syndrome (1632) Hiroe Itami, Kinta Hatakeyama, Masanori Matsumoto, Shigeo Hara, Makiko Yoshida, Yujiro Asada, Sho Sasaki, Tomoyuki Otani, Tomoko Uchiyama, Tokiko Nakai, Masato Takano, Chiho Ohbayashi. Nara Medical University, Kashihara, Nara, Japan; Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; Hyogo Prefectural Kobe Children s Hospital, Kobe, Hyogo, Japan; University of Miyazaki, Miyazaki, Japan. 221 Renal Pathology Findings in POEMS Syndrome (1615) Mariam P Alexander, Lynn D Cornell, Thomas Czeczok. Mayo Clinic, Rochester, MN. 222 Light Chain Proximal Tubulopathy of Undetermined Significance (1626) Toshi Ghosh, Nelson Leung, Samih H Nasr, Mariam P Alexander, Mary E Fidler, Loren P Herrera Hernandez, Lynn D Cornell. Mayo Clinic, Rochester, MN. 223 Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy: Mimickers of Myeloma Like Cast Nephropathy (1634) Muhammad S Khurram, Warda Ibrar, Ahmed Alrajjal, Hong Qu. St John Hospital and Medical Center, Detroit, MI. 224 Sox9 Potentially Distinguishes Focal Segmental Glomerulosclerosis from Minimal Change Disease (1618) Beth L Braunhut, Vincent M Cracolici, Kammi J Henriksen, Mariana M Cajaiba, Anthony Chang. The University of Chicago, Chicago, IL; Lurie Children s Hospital, Chicago, IL. 225 D-Penicillamine Partially Amiliorates Tubulointerstitial Fibrosis by Inhibition of Lysyl Oxidase-Like 2 (1635) Jisup Kim, Sung-Eun Choi, Nara Jeon, Hyeon Joo Jeong, Beom Jin Lim. Yonsei University College of Medicine, Seoul, Korea. 226 Myc Expression in 4 Cases of Primary Renal Intravascular Lymphoma (1623) Michelle Don, Ana-Tereza Kabira, Girish Venkataraman, Qin Huang, Christine VanBeek, Cynthia Nast, Mark Haas, Serhan Alkan. Cedars-Sinai Medical Center, Los Angeles, CA. 227 Convergence of Vasculopathy and Vasculitis: Digital Profiling as a Novel Approach for the Study of the Renal Biopsy (1649) Jia Xu, Milan Rosen, Christina I Luffman, Beverly E Faulkner-Jones, Seymour Rosen. BIDMC, Boston, MA. 228 Renal Biopsy Data Analysis from Whole Slide Imaging: A Novel Holistic Approach (1624) Beverly E Faulkner-Jones, Charles Law, Milan Rosen, Devin Rosen, Christina I Luffman, Seymour Rosen. BIDMC, Boston, MA; Kitware Inc, Clifton Park, NY. 229 Molecular Assessment of Transplant Renal Biopsies and Comparison with Histology (1614) John Aird, Claire Kennedy, Donal Sexton, Jeff Reeve, Philip Halloran, Declan de Freitas, Brendan Doyle. Royal College of Surgeons in Ireland, Dublin, Ireland; Beaumont Hospital, Dublin, Ireland; University of Alberta, Edmonton, AB, Canada. 230 Low Ratio of CD68/Kidney Injury Molecule-1 (KIM-1) Expression in the Proximal Tubules of Renal Biopsies Is Associated with Worse Renal Recovery at 6 Month Follow-Up (1647) Nicholas D Ward, Ping L Zhang. Beaumont Health, Royal Oak, MI. 182

243 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall 1 LIVER 231 Characterization of Primary Human Hepatic Stellate Cells (1686) Sami G Musallam, Jacopo Baglieri, Xiao Liu, Mojgan Hosseini, Daniel Zhu, Sharon Presnell, Ken Dorko, Tatiana Kisseleva, David Brenner. UCSD, La Jolla, CA; Samsara Sciences, San Diego, CA. 232 Inhibition of Cyclic Adenosine Monophosphate (camp)-response Element-Binding Protein (CREB)- Binding Protein (CBP)/β-Catenin Directly Attenuates the Hepatocytes-Mediated Fibrogenesis (1684) Yuki Mizutani, Kiminori Kimura, Hiroyuki Kouji, Hironori Koga, Kenichi Hrada. Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; PRISM Pharma Co., Ltd, Yokohama, Japan; Kurume University School of Medicine, Kurume, Japan. 233 Adult Giant Cell Hepatitis: Morphological and Etiological Findings (1667) Thomas Czeczok, Michael S Torbenson, Tsung-Teh Wu, Vishal S Chandan. Mayo Clinic, Rochester, MN. 234 Liver Tumors in Patients with Familial Adenomatous Polyposis (1666) Thomas Czeczok, Tsung-Teh Wu, Lisa man, Michael S Torbenson, Vishal S Chandan. Mayo Clinic, Rochester, MN. 235 Albumin In-Situ Hybridization May Be Positive in Adenocarcinomas and Other Tumors from Diverse Sites (1680) Heidi Lehrke, Jennifer M Boland, Taofic Mounajjed, Samar Said, Saba Yasir, Vishal S Chandan, Sejal Shah, Thomas Smyrk, Lizhi Zhang, Rondell Graham. Mayo Clinic, Rochester, MN. 236 Detection of Albumin Expression by RNA In Situ Hybridization Is a Sensitive and Specific Method for Identification of Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas (1682) Fan Lin, Jianhui Shi, Hanlin L Wang, Xiao-Jun Ma, Robert Monroe, Yuling Luo, Zongming E Chen, Haiyan Liu. Geisinger Medical Center, Danville, PA; Advanced Cell Diagnostics, Hayward, CA; UCLA, Los Angeles, CA. 237 Combined Hepatocellular Cholangiocarcinoma with Stem Cell Features: Pitfalls in Diagnosis (1705) Linlin Wang, Dhanpat Jain, Nafis Shafizadeh, Sanjay Kakar. UCSF, San Francisco, CA; Yale University, New Heaven, CT; Kaiser, Woodland Hills, CA. 238 Utility of 5hmC Immunohistochemical Expression in the Diagnosis of Hepatocellular Carcinoma (1714) Xiaoqin (Cynthia) Zhu, Benjamin Chen. UMass Memorial Medical Center, Worcester, MA. 239 Serum Amyloid A (SAA) and C-Reactive Protein (CRP) Are Commonly Positive in Hepatocellular Carcinoma and Expression Levels Stratify According to Etiology and the Absence of Cirrhosis (1701) Mohanad Shaar, Ayako Suzuki, Craig Poster, Gustaaf de Ridder, Xuefeng Zhang, Mary Kate Cronin, Shannon McCall, Diana Cardona, Manal Abdelmalek, Salvatore Pizzo, Xiaoyin Sara Jiang, Michaela Lefaivre, Cynthia Guy. Duke University Medical Center, Durham, NC; University of Arkansas for Medical Sciences, Little Rock, AZ. 240 Identifying Mutation Profile in Hepatocellular Carcinoma by Targeted Next-Generation Sequencing (1675) Yanfei Huang, Kimberly J Newsom, Petr Starostik, Ashwini K Esnakula, Lizette Vila Duckworth, Chen Liu. University of Florida, Gainesville, FL. 241 In Situ Hybridization for MiR-21 in Hepatocellular Carcinoma (1678) Anne Koehne de Gonzalez, Anthony Rubino, Shauna Levinson, Manoj Gandhi, Helen E Remotti, Stephen M Lagana. Columbia University, New York, NY; Thermo Fisher Scientific, Santa Clara, CA. 242 Hepatocellular Carcinoma in Primary Sclerosing Cholangitis: 10-Year Experience at a Transplant Center (1691) Juan Putra, Thomas D Schiano, Stephen C Ward, M Isabel Fiel. Icahn School of Medicine at Mount Sinai, New York, NY. 243 CCL2/CCR2 Axis Is Involved in Hepatocellular Carcinoma (1696) Taha Sachak, Kun-Yu Teng, Kalpana Ghoshal, Lianbo Yu, Wei Chen, Wendy L Frankel. The Ohio State University Wexner Medical Center, Columbus, OH. 244 Characterization of Morphology, Microsatellite Instability, and Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma (1670) Clifton G Fulmer, Meredith Pittman. New York Presbyterian-Weill Cornell Medicine, New York, NY. 245 Cancer Gene Sequencing of Hepatic Small Vessel Neoplasm (HSVN) and Hepatic Cavernous Hemangioma (1677) Nancy M Joseph, Elizabeth M Brunt, Celia Marginean, ILKe Nalbantoglu, Dale C Snover, Swan N Thung, M M Yeh, Linda Ferrell, Ryan Gill. UCSF, San Francisco, CA; Washington University, St. Louis, MO; Ottawa Hospital, Ottawa, ON, Canada; Fairview Southdale Hospital, Edna, MN; Mount Sinai Health System, New York, NY; University of Washington, Seattle, WA. 183

244 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Hepatic Sclerosed Hemangioma Can Mimic Segmental Atrophy (1669) Jennifer J Findeis-Hosey, Raul S Gonzalez. Univ. of Rochester Med. Ctr., Rochester, NY. 247 Hepatic Epithelioid Angiomyolipoma: Immunohistochemical Pitfalls in Diagnosis (1708) Zhen Yan, Xin Chen, Sanjay Kakar. UCSF, San Francisco, CA. 248 Glypican 3 as a Serum Marker for Hepatoblastoma (1712) Shengmei Zhou, Maurice RG O Gorman, Fusheng Yang, Kevin Andresen, Larry Wang. Children s hospital of Los Angeles, Los Angeles, CA. 249 Feasibility and Utility of In-Situ Hybridization for Micro- RNA 21 in Intrahepatic Cholangiocarcinoma (1693) Anthony Rubino, Anne Koehne de Gonzalez, Shauna Levinson, Manoj Gandhi, Helen E Remotti, Stephen M Lagana. Columbia University, New York, NY; Affymetric, ThermoFisher Scientific, Santa Clara, CA. 250 Clinicopathologic Features of Hepatic Lymphoma, a Large Retrospective Study (1681) Yiting Li, Patrick Treseler, Sonam Prakash, Ryan M Gill. UCSF Medical Center, San Francisco, CA. 251 Correlation Between C4d Immunoreactivity and Donor- Specific Antibody in Posttransplant Liver Biopsies Showing Central Perivenulitis (1703) Hong Shen, Sharon S Zhang, Hanlin L Wang. David Geffen School of Medicine at UCLA, Los Angeles, CA. 252 Activity of Autoimmune Hepatitis in Explanted Livers Correlates with Acute Cellular Rejection and Disease Recurrence During First Year Post Transplantation (1694) Natalia Rush, Juan P Trivella, Marshall McCabe, Craig Lammert, Marwan Ghabril, Romil Saxena. Indiana University School of Medicine, Indianapolis, IN. 253 Isolated Vascular v Lesions in Liver Allografts: Appropriate Work-Up for This Puzzling Finding (1639) Mariana Moreno Prats, Heather L Stevenson, Anthony J Demetris. University of Texas Medical Branch, Galveston, TX; University of Pittsburgh Medical Center, Pittsburgh, PA. NEUROPATHOLOGY & OPHTHALMIC PATHOLOGY 254 Retrospective Analysis of Molecular and Immunohistochemical Characterization of 381 Primary Brain Tumors (1721) Leomar Ballester, Gregory N Fuller, Suzanne Z Powell, Erik P Sulman, Keyur P Patel, Rajyalakshmi Luthra, Mark J Routbort. Houston Methodist Hospital, Houston, TX; The UT MD Anderson Cancer Center, Houston, TX. 255 The Histologic and Molecular Features of Pediatric and Adult Gliomas with Alterations in FGFR1 and FGFR3 (1720) Tejus A Bale, Sanda Alexandrescu, Monica Manam, Neal I Lindeman, Adrian Dubuc, Azra H Ligon, Keith L Ligon. Brigham and Women s Hospital, Boston, MA; Boston Children s Hospital, Boston, MA. 256 GlioSeq Targeted NGS Panel Provides Accurate Genetic Profiling of Pediatric CNS Tumors for Clinical Care (1730) Soufiane El Hallani, Ronald L Hamilton, Craig M Horbinski, Ian F Pollack, Abigail Wald, Yuri Nikiforov, Somak Roy, Marina N Nikiforova. University of Pittsburgh Medical Centre, Pittsburgh, PA; Northwestern Memorial Hospital, Chicago, IL. 257 Detection of IDH1/2 and TP53 Mutations and MGMT Methylation in High Grade Gliomas of the Central Nervous System by the Next Generation Sequencing and Pyrosequencing (1766) Yougen Zhan, Tatyana Sidorenko, Aneta Waluszko, David Y Zhang, Fei Ye. Mount Sinai Hospital, New York, NY. 258 Determining IDH Status in Gliomas Using IDH1 R132H Antibody and Polymerase Chain Reaction (1736) Dibson D Gondim, Melissa AH Gener, Liang Cheng, Eyas M Hattab. Indiana University, Indianapolis, IN; University of Louisville, Louisville, KY; Children s Mercy Hospital, Kansas City, MO. 259 Differential Exon Expression Analysis in Glioblastomas Multiforme by Quantitative Statistics (1717) Jaudah A Al-Maghrabi, Hans-Juergen Schulten, Deema Hussein, Sajjad Karim, Fahad Al-Ghamdi, Saleh Baeesa, Mohammed Bangash, Mohammed Al-Qahtani. Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Center of Excellence in Genomic Medicine Research, Jeddah, Saudi Arabia; King Abdulaziz University, Jeddah, Saudi Arabia. 260 Analysis of Immunobiologic Markers in Primary and Recurrent Glioblastoma (1738) Wesley Hiser, Paul Kubilis, Duane Mitchell, Jesse L Kresak. University of Florida, Gainesville, FL. 261 Upregulated MiR-125, MiR-181d and MiR-221 Expression Levels Are Associated with Poor Prognosis in Glioblastoma Patients with Unmethylated MGMT Promoter (1724) Yen-Ying Chen, Chih-Yi Hsu, Donald M-T Ho. Taipei Veterans General Hospital, Taipei, Taiwan. 262 RMDO-2, Olig-2 and Synaptophysin Expression Is a Frequent Event in Malignant Melanoma: Diagnostic Pitfalls in Glial Tumor (1732) Taliya Farooq, Esther C Yoon, Anas Mashlah, Sina Zomorrodian, George Kleinman. New York Medical College at Westchester Medical Center, Valhalla, NY. 184

245 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Does Molecular Profile Trump Morphology in Glial Neoplasms: An Indian Perspective, Based on the Current WHO Classification (2016) (1752) Shivani Sharma, Sambit K Mohanty, Arbind Singh, Anurag Sharma, Beklaswar Salona, Mukesh Kumar, Mohit Kumar, Santosh Pandey, Rahul Katara, Sankar Mohan, Vipin Kumar, Joydeep Mukherjee, Ajay Pandita, Lata Kini. CORE Diagnostics, Gurgaon, India. 264 Is It Worthy to Reclassify Already Diagnosed Oligoastrocytomas in the Setting of the New WHO Criteria? (1748) Irma Ramos-Oliver, Laura Abraira, Jordi Temprana- Salvador, Carolina Montecino, Jessica Camacho, Cristina Auger, Francisco Martínez-Ricarte, Santiago Ramon y Cajal, Elena Martínez-Sáez. Vall d Hebron University Hospital, Barcelona, Spain. 265 Is Non-HIV Related DLBCL in the Brain Always Primary? (1756) Hammad Tashkandi, Marta E Couce, Mark Cohen. University Hospitals Cleveland Medical Center, Cleveland, OH. 266 Expression of Sonic Hedgehog (SHH) Signaling Molecules in Retinoblastoma and Medulloblastoma (1740) Nafiseh Janaki, Amad Awadallah, Mark Cohen, Marta E Couce. University Hospitals Cleveland Medical Center, Cleveland, OH. 267 Clinicopathological Features of C11orf95-RELA Positive Ependymomas in a Series of Adult and Young Patients with Long Follow-Up (1750) Sabrina Rossi, Luisa Toffolatti, Riccardo Signori, Elena Boscato, Lucia Zanatta, Anna G Volpato, Laura Valori, Matilde Cacciatore, Antonella Peciarolo, Stefano Ascani, Cristina Pizzato, Paolo Grotto, Elisabetta Marton, Caterina Giannini, Pierluigi Longatti. Treviso General Hospital, Treviso, Italy; S. Maria Hospital, Terni, Italy; Mayo Clinic, Rochester, MN. 268 Aggressive Genetic Signature Correlates with Tumor Cell Proliferation in Supratentorial Ependymoma (1745) Michael B Miller, Adrian Dubuc, Azra H Ligon, Keith L Ligon. Brigham and Women s Hospital, Boston, MA. 269 Distinctive CA9 Expression Patterns in Clear Cell, Microcystic and Angiomatous Meningioma Variants (1725) Rati Chkheidze, Charles L White, Kimmo Hatanpaa, Chunyu Cai. UT Southwestern Medical Center, Dallas, TX. 270 MUC4 Is Expressed in Meningioma with High Sensitivity for the Microcystic Variant (1755) Toyohiro Tada, Hisashi Tateyama, Megumi Yoshida, Takashi Matsumoto. Toyokawa City Hospital, Toyokawa, Japan; Kasugai City Hospital, Kasugai, Japan. 271 Ki 67 Labeling Index Is Superior to IMP3 in Prediction of Meningioma Recurrence; a Pilot Study (1751) Mohamed M Shareef, Doha E Fayed, Rania E Wasfy, Karima I Marey. Tanta University, School of Medicine, Tanta, Egypt; Kafer El Sheikh General Hospital, Kafer El Sheikh, Egypt. 272 H3 K27M Mutation in Gangliogliomas Can Be Associated with Poor Prognosis (1743) Bette Kleinschmidt-DeMasters, Andrew Donson, Nicholas Foreman, Kathleen Dorris. University of Colorado Anschutz Medical Campus, Aurora, CO; Children s Hospital Colorado, Aurora, CO. 273 Hemangioblastoma: A Targeted Next Generation Sequencing Study (1765) Esther C Yoon, Jian Zhuge, George Kleinman, John T Fallon, Minghao Zhong. New York Medical College at Westchester Medical Center, Valhalla, NY. 274 Single Nucleotide Polymorphism Microarray Analysis of Pineocytomas (1719) Tiffany Baker, Iya Znoyko, Daynna J Wolff, Cynthia Welsh. Medical University of South Carolina, Charleston, SC. 275 Clinicopathologic Study of Granular Cell Astrocytomas (1761) Maria Adelita Vizcaino, Peter C Burger, Fausto Rodriguez. Johns Hopkins University School of Medicine, Baltimore, MD. 276 Molecular Characterization of a Central Nervous System Inflammatory Myofibroblastic Tumor: Neuropathologists and Molecular Pathologists Adding Value (1759) Jose E Velazquez Vega, Abigail L Goodman, Stewart Neill, Tong Yang, Omid Rouhi, Stephen Hunter, Daniel J Brat, Charles E Hill, Matthew Schniederjan. Emory University Hospital, Atlanta, GA; Children s Hospital of Atlanta, Atlanta, GA. 277 Focal Cortical Dysplasia-Associated Low-Grade Glioma: Expending the BRAF Mutations Concept (1718) Azniv Azar, Siraj M El Jamal, Youssef Al Hmada, Ali G Saad. University of Mississippi Medical Center, Jackson, MS. 278 Unexpected Pathologic Findings in a Subset of Malformations of Cortical Development (1746) Vera Paulson, Rebecca Folkerth, Sanda Alexandrescu. Boston Children s Hospital, Boston, MA; Harvard Medical School, Boston, MA. 279 The Role of Histopathologic Subtype in the Setting of Hippocampal Sclerosis-Associated Mesial Temporal Lobe Epilepsy (1734) Jordan M Gales, Richard A Prayson. Cleveland Clinic Lerner College of Medicine, Cleveland, OH; Cleveland Clinic, Cleveland, OH. 185

246 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall The Importance of Peri-Adventitial Soft Tissue Examination in Temporal Artery Biopsies for Suspected Giant Cell Arteritis (1722) Paula Blanco, James Farmer. University of Ottawa, Ottawa, ON, Canada. 288 Prevalence of IgG4-Related Disease in Chronic Orbital Inflammatory Lesions (1749) Juan Rong, Christina Di Loreto, Vivian S Snyder, Jonathan H Lin. University Of California, San Diego, San Diego, CA. 281 Embolic Foreign Material in the Central Nervous System of Children with Heart Disease and a History of Instrumentation: An Update (1757) Matthew Torre, Mirna Lechpammer, Audrey Marshall, Amy Juraszek, Robert Padera, Elizabeth Bundock, Sara Vargas, Rebecca Folkerth. Brigham and Women s Hospital, Boston, MA; Children s Hospital Boston, Boston, MA; University of California Davis, Sacramento, CA; Office of the Chief Medical Examiner, Burlington, VT. 282 Ultrastructural Examination of Skin Biopsies May Assist in Diagnosing Mitochondrial Cytopathy When Muscle Biopsies Yield Negative Results (1744) John L McAfee, Christine B Warren, Richard A Prayson. Cleveland Clinic Lerner College of Medicine, Cleveland, OH; Cleveland Clinic, Cleveland, OH. 283 Morphologic Features of Inflammatory Myopathy Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies (1723) Bruna Cerbelli, Annalinda Pisano, Serena Colafrancesco, Marco Biffoni, Silvia Berni, Valeria Ricceri, Roberta Priori, Guido Valesini, Giulia d Amati, Carla Giordano. Sapienza University, Rome, Italy. 284 SNP-Based DNA Microarray Analysis May Be More Effective Than Fluorescence In-Situ Hybridization in Identifying BAP1 Alterations in a Uveal Melanoma Cohort (1754) James Solomon, Sarah S Murray, Marie dell Aquila, John A Thorson, Jonathan H Lin. Univ of California, San Diego, San Diego, CA. 285 Diverse Patterns of Involvement in Intraocular Lymphoma: Learning from Four Enucleation Specimens (1716) Osamah AL Badri, Diva Regina Salomao, Joaquin Garcia, Jose Pulido. Mayo Clinic, Rochester, MN. 286 Mantle Cell Lymphoma (MCL) of Orbit and Ocular Adnexa: Clinicopathological Features and Diagnostic Utility of SOX11 Monoclonal Antibody Immunohistochemistry (IHC) (1729) Mukul Divatia, Andreia Barbieri, Juan Ortiz, April Ewton, Patricia Chevez-Barrios. Houston Methodist Hospital, Houston, TX. 287 Dutcher Bodies in Lacrimal Glands: Not Always a Reliable Feature in Distinguishing Malignant from Benign Lymphoid Infiltrates (1747) Sabrina Racine Brzostek, Jeffrey Ahlstedt, Yanhua Wang. Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY. 289 Primary Histiocytoid/signet Ring Cell Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-cadherin/B-catenin Complex (1728) Maria D Estopinal, Lavinia P Middleton, Michelle D Williams. MD Anderson Cancer Center, Houston, TX. 290 PD-L1 Expression in Sebaceous Carcinoma of the Eyelid Implicates the Utility of Immune Checkpoint Blockade (1758) John Van Arnam, Jonathan L Curry, Priyadharsini Nagarajan, Phyu P Aung, Alexander J Lazar, Victor G Prieto, Bita Esmaeli, Michael T Tetzlaff. The University of Texas MD Anderson Cancer Center, Houston, TX. 291 New Hypothesis in the Pathogenesis of Diabetic Retinopathy (1735) Alireza Ghaffarieh. Indiana University, Indianapolis, IN. PULMONARY PATHOLOGY 292 Neoplastic Architectural Remodeling as an Aggressive Histological Indicator of Early Stage Lung Adenocarcinoma (1954) Noriko Motoi, Masaya Yotsukura, Aoi Sukeda, Hisao Asamura, Shun-ichi Watanabe, Nobuyoshi Hiraoka. National Cancer Center Hospital, Chuo-ku, Tokyo, Japan; Keio University School of Medicine, Shinjukuku, Tokyo, Japan. 293 Morule-Like Changes in Lung Adenocarcinoma (1968) Pallavi A Patil, Bassam Aswad, Maria L Garcia-Moliner. Brown University Rhode Island Hospital, Providence, RI. 294 Concordance Between Biopsy and Resection Specimens in Assessing Lung Adenocarcinoma Histologic Growth Patterns (1908) Hannah M Christensen, Emilian Racila. University of Minnesota, Minneapolis, MN. 295 Appropriate Use of Immunohistochemistry in the Diagnosis of Lung Cancer on Biopsy: A Retrospective Comparison from Four Academic Centers (1981) Lauren E Rosen, Hussein Alnajar, Vijayalakshmi Ananthanarayanan, Paolo Gattuso, Lifang Liu, Kirtee Raparia, Aliya N Husain. University of Chicago, Chicago, IL; Rush University Medical Center, Chicago, IL; Loyola University, Maywood, IL; Northwestern University, Chicago, IL. 186

247 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall MMP-1 as a Marker of Adverse Clinical Outcome of Pulmonary Adenocarcinoma Patients: The Correlation Between MMP-1 Overexpression and Clinicopathological Factors and EGFR-TKI Resistance (1982) Ryoko Saito, Yasuhiro Miki, Naoya Ishida, Shuko Hata, Hironobu Sasano. Tohoku University School of Medicine, Sendai, Miyagi, Japan; Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. 297 Steroid Hormone Receptor Protein Expression by Gender and Smoking in Non-Small Cell Lung Cancer: SWOG S0424 (1907) Ting-Yuan David Cheng, Amy K Darke, Mary W Redman, Gary R Zirpoli, Warren Davis, Rochelle Payne Ondracek, Wiam Bshara, Robert Kratzke, Julian R Molina, Jill M Kolesar, Yuhchyau Chen, Robert M MacRae, James Moon, Philip Mack, David R Gandara, Karen Kelly, Regina M Santella, Kathy S Albain, Christine B Ambrosone. Roswell Park Cancer Institute, Buffalo, NY; SWOG Statistical Center/Fred Hutchinson Cancer Research Center, Seattle, WA; University of Minnesota, Minneapolis, MN; Mayo Clinic, Rochester, MN; University of Wisconsin-Madison, Madison, WI; University of Rochester Medical Center, Rochester, NY; The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada; UC Davis Cancer Center, Sacramento, CA; Columbia University, New York, NY; Loyola University Chicago, Chicago, IL. 298 Lung Adenocarcinoma with GATA6 Expression Is Associated with Invasive Mucinous Adenocarcinoma Histology and HNF4alpha, but a Better Prognosis (1957) Naoki Nakajima, Akihiko Yoshizawa, Hironori Haga. Kyoto University Hospital, Kyoto, Japan. 299 Ultrasensitive ALK (D5F3) Immunohistochemistry in Inflammatory Myofibroblastic Tumor of the Lung and Trachea: A Multi-Institution Series of 34 Cases (1955) Sanjay Mukhopadhyay, Deepali Jain, Andrea V Arrossi, Masakazu Soda, Charanjeet Singh, Junya Fukuoka, Lara Pijuan, John D Gentry, Ola El-Zammar, Sergej Griff, Jesse K McKenney, Carol Farver. Cleveland Clinic, Cleveland, OH; All India Inst of Medical Sciences, Delhi, India; Nagasaki University, Sakamoto, Nagasaki, Japan; Florida Hospital, Orlando, FL; Hospital del Mar, Barcelona, Spain; SUNY Upstate Med Univ, Syracuse, NY; HELIOS Kliniken Berlin, Berlin, Germany; Methodist Hospital, Omaha, NE. 300 Limited Molecular Testing (MT) of Multiple Pulmonary Tumors in a Single Resection Specimen: Correlation with Morphologic Staging (1965) Carlos Pagan, Jonas Heymann, Mark Stoopler, Adrian Sacher, Catherine Shu, Naiyer Rizvi, John Crapanzano, Anjali Saqi. Columbia University Medical Center, New York, NY. 301 Intratumoral Molecular and Proteomic Heterogeneity in Lung Adenocarcinoma. How Can We Address It? (1983) Irene Sansano, Sherley Diaz, Javier Hernandez-Losa, Douglas Sanchez, Santiago Ramon y Cajal. HU Vall d Hebron, Barcelona, Barcelona, Spain. 302 A Comparison of ALK Gene Rearrangement and ALK Protein Expression in Primary Lung Carcinoma and Matched Metastasis (2000) Humberto Trejo Bittar, Sanja Dacic. UPMC, Pittsburgh, PA. 303 Profiling of Tumor Mutational Burden and PD1/PDL1 Immunohistochemistry (IHC) in Non-Small Cell Lung Cancer (1920) Julia A Elvin, Michael E Goldberg, Laurie M Gay, James Suh, Jo-Anne Vergilio, Shakti H Ramkissoon, Siraj M Ali, Alexa Schrock, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Jeffrey Ross. Foundation Medicine, Inc., Cambridge, MA; Albany Medical College, Albany, NY. 304 Validation of a Rapid Point-of-Care Test to Detect Epidermal Growth Factor Receptor Gene Mutations in Patients with Lung Cancer by Using Cell-Free DNA Supernatants (1899) Shiho Asaka, Akihiko Yoshizawa. Shinshu University Hospital, Matsumoto, Nagano, Japan; Kyoto University Hospital, Kyoto, Japan. 305 KRAS Mutation Is Highly Prevalent and Predicts Recurrence in Patients with Primary Invasive Mucinous Adenocarcinoma of the Lung (1937) Mohamed K Kamel, Navneet Narula, Kyung Park, Brendon M Stiles, Jeffrey L Port, Helen Fernandes, Nasser K Altorki. New York Presbyterian Hospital Weill Cornell Medicine, New York, NY. 306 PD-L1 Expression in Non-Small Cell Lung Carcinoma (NSCLC): Feasibility of Cytology and Its Comparison with Resection and Small Biopsies (1928) Jonas J Heymann, Carlos Pagan, John Crapanzano, Ladan Fazlollahi, Mehrvash Haghighi, William Bulman, Mark Stoopler, Joshua Sonett, Adrian Sacher, Catherine Shu, Naiyer Rizvi, Anjali Saqi. Columbia University Medical Center, New York, NY. 307 A Comparative Analysis of PD-L1 Distribution in Primary NSCLC and Metastatic Tumors to the Lung (1989) Wijendra Senarathne, Peggy Gates, Semir Vranic, Zoran Gatalica. Caris Life Sciences, Phoenix, AZ; University of Sarajevo, Sarajevo, Bosnia and Herzegowina. 308 Concordance of PD-L1 Expression Between Core Biopsy and Resection Specimens of Non-Small Cell Lung Cancer (1927) Jacob Grange, Edward B Stelow. University of Virginia School of Medicine, Charlottesville, VA. 187

248 ABSTRACTS POSTER SESSION POSTER III SESSION Tuesday, March Day, 07, Date, :30 0:00 AM AM - 12:00-0:00 PM Exhibit Hall Correlation Between Programmed Death-1 (PD-1) Expression in Tumor Infiltrating Lymphocytes and Programmed Death Ligand-1 (PD-L1) Expression in Non-Small Cell Lung Carcinoma (1913) Brandon Driver, Ross A Miller, Michael Deavers, David Tacha, Eric Bernicker, Philip T Cagle. Houston Methodist Hospital, Houston, TX; Biocare Medical LLC, Concord, CA. 310 Loss of BAP-1 Expression in Atypical Mesothelial Proliferations Helps to Predict Malignant Mesothelioma (1971) Raghavendra Pillappa, Joseph J Maleszewski, William R Sukov, Patrick P Bedroske, Jennifer M Boland, Eunhee S Yi, Tobias Peikert, Marie-Christine Aubry, Anja C Roden. Mayo Clinic, Rochester, MN. 311 BAP1 Immunohistochemistry Differentiates Pleural Mesothelioma Not Only from Reactive Mesothelial Hyperplasia but Also from Metastatic Pleural Tumors (2011) Masayo Yoshimura, Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Tomoyuki Hida, Yoshinao Oda, Kazuki Nabeshima. Fukuoka University School of Medicine and Hospital, Fukuoka, Japan; Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 312 A Subset of Malignant Mesotheliomas in Young Adults Are Associated with Recurrent EWSR1-ATF1 Fusions (1910) Patrice Desmeules, Philippe Joubert, Hikmat Al- Ahmadie, Christopher DM Fletcher, Deborah Delair, Natasha Rekhtman, Marc Ladanyi, William Travis, Cristina R Antonescu. Memorial Sloan Kettering Cancer Center, New York, NY; Quebec Heart and Lung Institute, Quebec City, QC, Canada; Brigham and Women s Hospital, Boston, MA. 313 Loss of BAP1 Expression Is Useful in the Distinction of Thymic Carcinoma from Thymoma (2004) Julie A Vrana, Marie-Christine Aubry, Eunhee S Yi, Anja C Roden. Mayo Clinic, Rochester, MN. 314 A Clinicopathologic and Molecular Analysis of 34 Mediastinal Germ Cell Tumors (GCT) Supporting a Dual Histogenesis for Teratomas (1939) Chia-Sui Kao, Dana Bangs, Thomas M Ulbright. Stanford University School of Medicine, Stanford, CA; Indiana University School of Medicine, Indianapolis, IN. 315 Mediastinal Synovial Sarcoma: Clinicopathological Analysis of 20 Cases with Molecular Confirmation (1999) Simone BSP Terra, Scott W Aesif, Joseph J Maleszewski, Andrew L Folpe, Jennifer M Boland. Mayo Clinic, Rochester, MN; University of Wisconsin, Madison, WI. 316 Alveolar Framework Alterations in Fibrosing Interstitial Lung Disease: A Three-Dimensional Reconstruction Study (1992) Angela Shih, Xiujun Fu, Lida Hariri, Tiffany Huynh, Eugene Mark, Yukako Yagi, Mari Mino-Kenudson. Massachusetts General Hospital, Boston, MA. 317 Programmed Cell Death Ligand 1 Is Expressed in a Subset of Pulmonary and Systemic Langerhans Cell Histiocytosis (2014) Xiaotun Zhang, Eunhee S Yi, Robert Vassallo, Anja C Roden. Mayo Clinic, Rochester, MN. 318 Histopathologic Features of IgG4-Related Lung Disease Associated with Carcinomas in the Lung: Report of 4 Cases (2009) Eunhee S Yi, Hee Eun Lee, Thomas V Colby, Mathieu C Castonguay, Charles H Aust, Jr., Henry D Tazelaar. Mayo Clinic, Rochester, MN; Mayo Clinic, Scottsdale, AZ; Dalhousie University, Halifax, NS, Canada; Lutheran Hospital of Indiana, Fort Wayne, IN. 319 Are Respiratory Bronchiolitis, Emphysema and Smoking-Related Interstitial Fibrosis (SRIF) Accurate Markers of Smoking Status? A Histologic Study of 119 Surgically Resected Lung Specimens (1966) Andrea Pannunzio, Sanjay Mukhopadhyay. Cleveland Clinic, Cleveland, OH. 320 Microcrystalline Cellulose Identification in a Series of 9 Lung Transplant Recipients (1902) John Carney, Alice L Gray, David N Howell, Elizabeth N Pavlisko. Duke University Medical Center, Durham, NC. 188

249 ABSTRACTS PROFFERED PAPERS Tuesday, March 07, :00 PM 2:45 PM CC HEMISFAIR 1 SECTION A INFORMATICS CHAIRED BY: GAURAV SHARMA AND S JOSEPH SIRINTRAPUN 1:00 Informatics for Prospective Biospecimen Procurement: Performance of a Web-Based Research Tissue Procurement Information System (RTP-IS) (1601) Anil Parwani, Randal L Mandt, David G Nohle, Leona W Ayers. The Ohio State University, Columbus, OH; Collaborative Human Tissue Network, Columbus, OH. 1:15 The Automatic Extraction and Categorization of 11,347 Large Bowel Polyps from 54,631 Free Text Surgical Pathology Reports (1580) Michael Bonert, Jennifer M Dmetrichuk, Asghar Naqvi. McMaster University/St. Joseph s Healthcare Hamilton, Hamilton, ON, Canada. 1:30 Extraction of Machine-Readable Data from Thyroid Fine Needle Aspiration Reports Supports the Need of Structured Data Implementation in Laboratory Information System (LIS) Software (1594) Razvan Lapadat, Christopher Garcia, Bryan Hunt, Tamar Giorgadze. Medical College of Wisconsin, Milwaukee, WI. 1:45 Using Machine Methods to Score Tumor-Infiltrating Lymphocytes in Lung Cancer (1613) Tianhao Zhao, Le Hou, Vu Nguyen, Yi Gao, Dimitris Samaras, Tahsin Kurc, Joel Saltz. Stony Brook University, Stony Brook, NY. 2:00 The Use of Computer Vision to Diagnose Squamous Intraepithelial Lesions of the Lower Female Genital Tract (1595) Xinyan Li, Vassilios Morellas, Nikolaos P Papanikolopoulos, Alexander M Truskinovsky. University of Minnesota, Minneapolis, MN; Roswell Park Cancer Institute, Buffalo, NY. 2:15 Diagnostic Implications of 2-Dimensional and 3-Dimensional High-Definition Videos in Anatomic Pathology (1596) Emilio Madrigal, Shyam Prajapati. Mount Sinai Health System, New York, NY. 2:30 Pathology Informatics 115 Years Ago: Analysis of Surgical Pathology Reports from a University Hospital Surgical Pathology Repertoire in 1901 (1597) Martin J Magers, Marina Selenica, Rajan Dewar. University of Michigan, Ann Arbor, MI; Carnegie Mellon University, Pittsburgh, PA. CC HEMISFAIR 3 SECTION B AUTOPSY / CARDIOVASCULAR: AUTOPSY CHAIRED BY: DANIEL DYE AND JERRI L MCLEMORE 1:00 The First Zika-Related Infant Mortality in the United States: An Autopsy Case Report (27) David Saulino, Elizabeth Gaston, Brianne Younke, Jeffrey A Conyers, Micheal Covinsky, Nina Tatevian, Meenakshi Bhattacharjee. University of Texas, Houston, TX. 1:15 A Window on the Autopsy. Nine Years of USCAP Abstracts (26) Cecilia Ridaura-Sanz, Ruy Lopez-Ridaura, Eduardo Lopez-Corella. National Institute of Pediatrics, Mexico City, Mexico; National Institute of Public Health, Cuernavaca, Mexico. 1:30 Rapid Autopsy and Collaboration: Opening Investigative Pathways for Research Teams (12) Jody E Hooper, Jowaly Schneider. Johns Hopkins University, Baltimore, MD. 1:45 Death within 30 Days of Fine Needle Aspiration: Post- Mortem Confirmation of FNA Diagnoses and the Contribution of FNA to Patient Mortality (24) David S Priemer, Dean A Hawley, Harvey M Cramer. Indiana University, Indianapolis, IN. CC HEMISFAIR 3 SECTION B AUTOPSY / CARDIOVASCULAR: CARDIOVASCULAR CHAIRED BY: GREGORY A FISHBEIN AND DEBRA L KEARNERY 2:00 Increased Histopathology in Marfan Syndrome Compared to Loeys-Dietz Syndrome and Non- Syndromic Aortas (325) Kevin Waters, Andrew Guajardo, Marc Halushka. Johns Hopkins University SOM, Baltimore, MD. 2:15 The Pathology of Subaortic Membranes: An Analysis of 83 Surgically Resected Cases with Molecular Genetic Correlation (310) Melanie Bois, Linnea M Baudhuin, Michelle L Kluge, Katrina E Kotzer, Laura J Train, Michael J Ackerman, Joseph J Maleszewski. Mayo Clinic, Rochester, MN. 2:30 Thrombus on the Inflow Cannula of the HeartWare HVAD: An Update (314) Carolyn H Glass, Gregory A Fishbein, Kyle C Strickland, Jaclyn C Watkins, Robert Padera. Brigham and Women s Hospital, Boston, MA; David Geffen School of Medicine, UCLA, Los Angeles, CA. CC 225 SECTION C NEUROPATHOLOGY CHAIRED BY: NADEJDA TSANKOVA AND MARIA MARTINEZ- LAGE ALVAREZ 1:00 CRX and FOXJ1 Immunohistochemistry Differentiates Papillary Tumors of the Pineal Region from Pineal Parenchymal Lesions (1726) Shannon Coy, Sonika Dahiya, Alexandre Vasiljevic, Sandro Santagata. Brigham and Women s Hospital, Boston, MA; Washington University School of Medicine, St. Louis, MO; Wertheimer Hospital, Lyon, France. 189

250 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 1:00 PM - Exhibit 2:45 PM Hall 1 1:15 A Recurrent Kinase Domain Mutation p.d463h in PRKCA Defines Chordoid Glioma of the Third Ventricle (1753) David Solomon, Benjamin Goode, Michael D Hyun, Nancy M Joseph, Jessica Van Ziffle, Nicholas Butowski, Daniel J Brat, Bette Kleinschmidt-DeMasters, Fausto Rodriguez, David N Louis, William Yong, Beatriz Lopes, Marc Rosenblum, Tarik Tihan, Andrew Bollen, Arie Perry. University of California, San Francisco, San Francisco, CA; Emory University, Atlanta, GA; University of Colorado, Denver, CO; Johns Hopkins University, Baltimore, MD; Massachusetts General Hospital, Boston, MA; University of California, Los Angeles, Los Angeles, CA; University of Virginia, Charlottesville, VA; Memorial Sloan Kettering Cancer Center, New York, NY. 1:30 BAP1 Mutations in Rhabdoid Meningiomas (1715) Malak Abedalthagafi. King Fahad Medical City, Riyadh, Saudi Arabia; King Abdulaziz for Science and Technology, Riyadh, Saudi Arabia; Harvard Medical School-Brigham and Women s Hospital, Boston, MA. 1:45 Loss of H3K27me3 Is a Poor Prognostic Factor for Meningioma (1727) Areli K Cuevas-Ocampo, David Raleigh, Ashley Wu, Bryan Tomlin, Joshua Menke, Gerald Reis, Arie Perry, Tarik Tihan, Melike Pekmezci. University of California in San Francisco, San Francisco, CA; Memorial Regional Hospital, Hollywood, FL. 2:00 Markers of Progression in Oligodendroglioma (1760) Jose E Velazquez Vega, Sameer H Halani, Safoora Yousefi, Fatemeh Amrollahi, Chad A Holder, Laila M Poisson, Brent Griffith, Jennifer Eschbacher, Michael Nalisnik, Jeffrey J Olson, Lee AD Cooper, Daniel J Brat. Emory University School of Medicine, Atlanta, GA; Henry Ford Hospital, Detroit, MI; St Joseph s Hospital, Phoenix, AZ. 2:15 CD163 and PD1-PDL1 Promote a Hostile Microenvironment for CD8 Lymphocytes and Predict Poorer Survival in Glioblastoma (1739) Miguel A Idoate, Alvaro Lopez Janeiro, Arturo Lecumberri, Iñigo Arana, Ricardo Diez-Valle, Francisco Guillen, Luis Mejias. University of Navarra, Pamplona, Navarra, Spain. 2:30 Programmed Cell Death Ligand 1 Expression in Uveal Melanoma Is Associated with Better Patient Outcome and Decreased Tumor Infiltrating Lymphocytes (1768) Pablo Zoroquiain, Evangelina Esposito, Beatriz Dias, Maria A Saornil, Ciro Garcia, Miguel N Burnier. McGill University, Montreal, QC, Canada; Pontificia Universidad Catolica de Chile, Santiago, Chile. CC 221 SECTION D GASTROINTESTINAL CHAIRED BY: LAWRENCE BURGART AND ILKE NALBANTOGLU 1:00 Morphologic and Immunohistochemical Characterization of Sessile Serrated Adenomas with Dysplasia (728) Cheng Liu, Neal Walker, Mark Bettington, Christophe Rosty, Barbara Leggett, Vicki Whitehall. QIMR Berghofer Medical Research Institute, Brisbane, Australia; Envoi Specialist Pathologists, Brisbane, Australia; Royal Brisbane and Women s Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. 1:15 Does Serrated Polyp Unclassified Exist? A Nationwide Study and Survey (726) Jingmei Lin, Dale C Snover, Robert D Odze, Xiuli Liu, Hwajeong Lee, Maria Westerhoff, Suntrea TG Hammer, ILKe Nalbantoglu, Oscar W Cummings, Hanlin L Wang, Barbara J McKenna, Scott R Owen, Jonathan McHugh, Romil Saxena, Jiaqi Shi, Eun-Young K Choi, Ashwini K Esnakula, Jesse L Kresak, John R Goldblum, Henry D Appelman, Douglas K Rex. Indiana University, Indianapolis, IN; Fairview Southdale Hospital, Edina, MN; Brigham and Womens Hospital, Boston, MA; University of Florida, Gainesville, FL; Albany Medical College, Albany, NY; University of Washington, Seattle, WA; University of Texas Southwester, Dallas, TX; Washington University, Saint Louis, MO; University of California, Los Angeles, CA; University of Michigan, Ann Arbor, MI; Cleveland Clinic, Cleveland, OH. 1:30 Mucin Rich Variant of Traditional Serrated Adenoma (MrTSA): A Distinct Morphological Variant (712) Sangeetha N Kalimuthu, Stefano Serra, Sara Hafezi- Bakthiari, Richard Colling, Lai Mun Wang, Runjan Chetty. UHN, Toronto, ON, Canada; OUH, Oxford, Oxfordshire, United Kingdom. 1:45 Crospovidone: A Common Incidental Finding in Gastrointestinal Pathology Specimens (683) Jennifer J Findeis-Hosey, Raul S Gonzalez. Univ. of Rochester Med. Ctr., Rochester, NY. 2:00 PD-L1 Expression in Post-Transplant Lymphoproliferative Disorder (PTLD) After Small Bowel Transplant (742) Abul Ala Syed Rifat Mannan, Hongfa Zhu, Alexandros D Polydorides, Noam Harpaz, Huai-Bin Mabel Ko. Mount Sinai Hospital, New York, NY. 2:15 Antibody Mediated Rejection in Intestinal Transplant: A Correlation of Histology with Donor Specific Antibodies (801) Jason V Scapa, Elaine Y Cheng, Bita V Naini. David Geffen School of Medicine at UCLA, Los Angeles, CA. 190

251 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 1:00 PM - Exhibit 2:45 PM Hall 1 2:30 Spectrum of Colonic Findings in Renal Transplant Patients (782) Meredith Pittman, Jose Jessurun, Rhonda K Yantiss. Weill Cornell Medicine, New York, NY. CC 304 SECTION E DERMATOPATHOLOGY CHAIRED BY: MEERA MAHALINGAM AND PAUL HARMS 1:00 Targeted DNA and RNA Sequencing in Malignant Peripheral Nerve Sheath Tumors (MPNST) AND Spindle AND Desmoplastic Melanomas (SDM): Novel Findings (513) George Jour, Nicole Andeen, Rami Al-Rohil, Meenakshi Mehrotra, Dzifa Duose, Benjamin Hoch, Zsolt B Argenyi, Ignacio I Wistuba, Victor G Prieto. MD Anderon Cancer Center at Cooper, Camden, NJ; University of Washington Medical center, Seattle, WA; Vanderbilt University Medical Center, Nashville, TN; MD Anderon Cancer Center, Houston, TX. 1:15 Immunohistochemical Characterization of Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) in Cutaneous Leiomyomas for Detection of Familial Cancer Syndromes (497) Cody Carter, Stephanie Skala, Arul M Chinnaiyan, Jonathan McHugh, Javed Siddiqui, Xuhong Cao, Douglas Fullen, Saravana Dhanasekaran, Amir Lagstein, May Chan, Rohit Mehra. University of Michigan, Ann Arbor, MI. 1:45 Isocitrate Dehydrogenase 1 (IDH1) Mutations in Melanoma Frequently Co-Occur with NRAS Mutations (523) Konstantinos Linos, Jason D Peterson, Sophie J Deharvengt, Francine B de Abreu, Keisuke Shirai, Gregory J Tsongalis, Laura Tafe. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 2:00 Genomic Alterations and Tumor Mutational Burden in Melanoma Subtypes (496) J Andrew Carlson, David M Jones, Julia A Elvin, Jo- Anne Vergilio, James Suh, Shakti H Ramkissoon, David Fabrizio, Garrett Frampton, Siraj M Ali, Alexa Schrock, Vincent Miller, Philip Stephens, Laurie M Gay, Jeffrey Ross. Albany Medical College, Albany, NY; Foundation Medicine, Inc., Cambridge, MA. 2:15 Primary Anorectal Melanoma: A Retrospective Analysis of 30 Patients (533) Rashmi Samdani, Michael T Tetzlaff, Jonathan L Curry, JIng Ning, Jin Piao, Phyu P Aung, Carlos A Torres- Cabala, Doina Ivan, Wei-Lien Wang, Alexander J Lazar, Merrick I Ross, Richard E Royal, Jennifer A Wargo, Jeffrey E Gershenwald, Michael A Davies, Victor G Prieto, Asif Rashid, Priyadharsini Nagarajan. The University of Texas- MD Anderson Cancer Center, Houston, TX. 2:30 To Evaluate the Utility of PAS Stained Skin Scrape Cytology Smear in Clinically Suspected Fungal Infections of the Skin (516) Ujjawal Khurana, Annika Marwah, Vivek Dey, Upasana Uniya, Rakesh S Hazari. PCMS & RC Bhopal, Bhopal, Madhya Pradesh, India; NIREH, ICMR, Bhopal, Madhya Pradesh, India. CC 301 SECTION F PANCREAS CHAIRED BY: MICHELLE D REID AND AATUR D SINGHI 1:00 Pathologic Findings in Gallbladders: An Analysis of the True Frequency and Distribution in 203 Totally Sampled and Mapped Gallbladders from a North American Population (1795) Bahar Memis, Michelle D Reid, Gabriella Bedolla, Juan Carlos Roa, Juan Carlos Araya, Enrique Bellolio, Miguel Villaseca, Alison Van Dyke, Yue Xue, Brian Quigley, Alyssa Krasinskas, Humbert Polito, Abheek Ghosh, Jill Koshiol, Volkan Adsay. Emory Uni., Atlanta, GA; Pontificia Uni. Católica de Chile, Santiago, Chile; Uni. de La Frontera, Temuco, Chile; NIH, Bethesda, MD. 1:15 Histologic Definition and Prognosis of T3 Gallbladder Adenocarcinoma (1804) Rebecca C Obeng, Bahar Memis, Takashi Muraki, Juan C Roa, Juan Carlos Araya, Enrique Bellolio, Miguel Villaseca, Hector Losada, Shishir Maithel, Juan M Sarmiento, Ken Cardona, Michelle D Reid, Volkan Adsay. Emory University, Atlanta, GA; Pontificia Uni Catolica de Chile, Santiago, Chile; Uni de La Frontera, Temuco, Chile. 1:30 Cholecystopathy of PancreatoBiliary Maljunction (PBM): Analysis of 75 Gallbladders from Patients with PBM Elucidates a Diagnostic Pattern of Mucosal Hyperplasia (1794) Bahar Memis, Takashi Muraki, Michelle D Reid, Takeshi Uehara, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Juan M Sarmiento, Alyssa Krasinskas, Volkan Adsay. Emory Uni., Atlanta, GA; Shinshu Uni., Nagano, Japan; Nagano Municipal Hosp., Nagano, Japan; Iida Municipal Hosp., Nagano, Japan; Saku Center Hosp., Nagano, Japan. 1:45 Prospective DNA Testing of 462 Pancreatic Cysts Reveals the Inclusion of Mutational Allelic Frequencies (AFs) Enhance the Detection of Malignancy in Intraductal Papillary Mucinous Neoplasms (IPMNs) (1813) Aatur D Singhi, Kevin McGrath, Randall E Brand, Herbert J Zeh, Jennifer S Chennat, Kenneth E Fasanella, Asif Khalid, Georgios I Papachristou, Adam Slivka, Melissa Hogg, Kenneth K Lee, J Wallis Marsh, Allan Tsung, Amer H Zureikat, Marina N Nikiforova. University of Pittsburgh Medical Center, Pittsburgh, PA. 191

252 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 1:00 PM - Exhibit 2:45 PM Hall 1 2:00 Well Differentiated Neuroendocrine Neoplasms of the Pancreas with a Ki67 Index Above 20% Differ from Their Poorly Differentiated Counterparts: Results from Massive Parallel Sequencing Applying a 409 Gene Panel (1791) Björn Konukiewitz, Moritz Jesinghaus, Wilko Weichert, Günter Klöppel, Nicole Pfarr. Technical University of Munich, Munich, Germany. 2:15 A Novel BRAF FISH Probe Identifies Potentially Targetable BRAF Rearrangement in Pancreatic Carcinomas with Acinar Differentiation (1782) Toshi Ghosh, Patricia T Greipp, Taofic Mounajjed, Stefano La Rosa, Alessandro Vanoli, Fausto Sessa, Lizhi Zhang, Rondell Graham. Mayo Clinic, Rochester, MN; Inst. Univ. de Pathologie, CHUV, Lausanne, Switzerland; Univ. of Pavia, Pavia, Italy; Univ. of Insubria, Varese, Italy. 2:30 Prognostic Significance of New AJCC Tumor (T) Stage in Patients with Pancreatic Ductal Adenocarcinoma Treated with Neoadjuvant Therapy (1777) Deyali Chatterjee, Matthew H Katz, Wai Chin Foo, Manonmani Sundar, Hua Wang, Gauri Varadhachary, Robert Wolff, Jeffrey Lee, Anirban Maitra, Jason B Fleming, Asif Rashid, Huamin Wang. University of Texas MD Anderson Cancer Center, Houston, TX. CC 302 SECTION G HEMATOPATHOLOGY CHAIRED BY: WAYNE TAM AND ABNER LOUISSANT 1:00 CTLA-4 Expression in Hodgkin Lymphoma Confers a Worse Overall Survival in Relapsed/refractory Patients (1518) Joo Song, Young S Kim, Parwiz Siaghani, David Cantu, Yuan Yuan Chen, Raju Pillai, Wing C Chan, Dennis D Weisenburger. City of Hope Medical Center, Duarte, CA. 1:15 Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1): A Novel Therapeutic Target in Mantle Cell Lymphoma (1527) Tian Tian, Chengfeng Bi, Ashley H Hein, Ji Yuan, Timothy Greiner, Charles A Enke, Julie M Vose, Ying Yan, Kai Fu. University of Nebraska Medical Center, Omaha, NE. 1:30 CD200 Expression in Mantle Cell Lymphoma Correlates with Absence of SOX11 Expression and a Leukemic Presentation (1422) Zhihong Hu, Yi Sun, Guilin Tang, Ken H Young, L Jeffrey Medeiros, Jeffrey L Jorgensen, Sa Wang. The University of Texas MD Anderson Cancer Center, Houston, TX. 1:45 Immunohistochemistry for LEF1 and SOX11 Adds Diagnostic Specificity in Small B-Cell Lymphomas (1491) Aruna Rangan, Erica F Reinig, Ellen D McPhail, Karen L Rech. Mayo Clinic, Rochester, MN. 2:00 Multiple Independent Clonal Origins of EBV+ Lymphoproliferative Disorders Revealed by Next Generation Deep Sequencing of the Immunoglobulin Heavy Chain Locus (1385) Yi Ding, Paul G Rothberg, Todd Laughlin, Richard Burack, Andrew Evans. University of Rochester, Rochester, NY. 2:15 MEF2B Is a Member of the BCL6 Gene Transcriptional Complex and Induces Its Expression in GC-DLBCL (1412) Zakaria Grada, Mohamed El Dinali, Hend Abulsayen, Myesa Emberesh, Elgenaid Hamadain, Ali G Saad, Siraj M El Jamal. University of Mississippi Medical Center, Jackson, MS; Brown University, Providence, RI; University of Miami, Miami, FL; Bronx-Lebanon Hospital Center, Bronx, NY. 2:30 Evaluation of Primary Mediastinal Large B Cell Lymphoma by Flow Cytometry (1399) Jonathan Fromm, Sindhu Cherian. University of Washington, Seattle, WA. CC 303 SECTION H PATHOBIOLOGY CHAIRED BY: SCOTT A TOMLINS AND MARIA E ARCILA 1:00 Clinical Value of Larger Multi-Gene Next-Generation Sequencing Panels (1824) Russell R Broaddus, Beate Litzenburger, Kenna Shaw, Jack Lee, Jiexin Zhang, Scott Kopetz. M.D. Anderson Cancer Center, Houston, TX. 1:15 High Prevalence of Germline DNA-Repair Defects (DRD) in Advanced Cancer Patients Detected Through Precision Medicine Program (1857) Verena Sailer, Tuo Zhang, Juan Miguel Mosquera, David J Pisapia, Chantal Pauli, Brian Robinson, Rema A Rao, Joanna Cyrta, Rob Kim, Terra J McNary, Marc H Schiffman, David M Nanus, Scott T Tagawa, Andrea Sboner, Olivier Elemento, Himisha Beltran, Mark A Rubin. Weill Cornell Medicine, New York, NY. 1:30 Pan-TRK IHC Is an Efficient and Reliable Screening Assay for Targetable NTRK Fusions (1837) Jaclyn F Hechtman, Alexander Drilon, David M Hyman, Ahmet Zehir, Snjezana Dogan, Maria E Arcila, Marc Ladanyi, Ryma Benayed, Achim Jungbluth. Memorial Sloan Kettering Cancer Center, New York, NY. 1:45 ALK Fusions in Cancers Other Than Non-Small Cell Lung Cancer Occur in a Wide Variety of Tumor Types and Respond Vigorously to Anti-ALK Targeted Therapy (1855) Jeffrey Ross, Siraj M Ali, Julia A Elvin, Alexa Schrock, James Suh, Jo-Anne Vergilio, Shakti H Ramkissoon, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Laurie M Gay. AlbanyMed Col, Albany, NY; FoundationMed, Cambridge, MA. 192

253 ABSTRACTS PROFFERED PAPERS Day, Tuesday, Date, 2016 March 07, 0: AM - 0:00 1:00 PM - Exhibit 2:45 PM Hall 1 2:00 Mutations in TSC1 and TSC2 Are Associated with High Tumor Mutational Burden and Therapeutic Options (1836) Laurie M Gay, Julia A Elvin, James Suh, Jo-Anne Vergilio, Shakti H Ramkissoon, Alexa Schrock, Siraj M Ali, David Fabrizio, Garrett Frampton, Vincent Miller, Philip Stephens, Jeffrey Ross. Foundation Medicine, Inc., Cambridge, MA; Albany Medical College, Albany, NY. 2:15 Genomic Landscape and Clinical Features of Carcinomas with ERBB2 S310 Extracellular Domain Mutations (1831) Patrice Desmeules, Ahmet Zehir, David M Hyman, Maria E Arcila, Marc Ladanyi. Memorial Sloan Kettering Cancer Center, New York, NY. 2:30 Profiling Toll-Like Receptor Pathway Mutations and Expression in Esophageal Adenocarcinoma (1834) Daffolyn R Fels Elliott, Juliane Perner, Martyn F Symmons, Brett Verstak, Xiaodun Li, Maria O Donovan, Nick J Gay, Rebecca C Fitzgerald. University of Cambridge, Cambridge, United Kingdom; Cambridge University Hospital NHS Trust, Cambridge, United Kingdom. POSTER SESSION IV Tuesday, March 07, :00 PM 4:30 PM Exhibit Hall 1 BONE & SOFT TISSUE PATHOLOGY 1 Lipoblasts in Spindle Cell and Pleomorphic Lipomas: A Close Scrutiny (70) Michael Michal, Dmitry V Kazakov, Ladislav Hadravsky, Kvetoslava Michalova, Petr Grossmann, Petr Steiner, Valentina Renda, Saul Suster, Michal Michal. Charles University, Medical Faculty and Charles University Hospital, Plzen, Czech Republic; Charles University, Third Medical Faculty and Charles University Hospital Kralovske Vinohrady, Praha, Czech Republic; MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI. 2 Upregulated BCL2 Expression as a Diagnostic Marker of Spindle Cell/Pleomorphic Lipoma with Deletion of MicroRNA-15a/16-1 Gene Locus at 13q14 (71) Toru Motoi, Akihiko Yoshida, Masumi Ogawa, Fumie Kakizaki, Ikuma Kato, Akiko Tonooka, Shinichiro Horiguchi, Tomotake Okuma, Takahiro Goto, Tsunekazu Hishima. Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan; National Cancer Center Central Hospital, Tokyo, Japan. 3 Expression of MDM2 and p16 in Angiomyolipoma (64) Xiaoqi Lin, William B Laskin. Northwestern University, Chicago, IL. 4 Well-Differentiated Liposarcoma of the Retroperitoneum: Is There Signifcance to Histologic Subtyping? (32) Tariq Al-Zaid, Davis R Ingram, Wei-Lien Wang, Alexander J Lazar. King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; The University of Texas MD Anderson Cancer Center, Houston, TX. 5 Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma (97) Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Yoshinao Oda, Shinya Toyokuni. Nagoya University Graduate School of Medicine, Nagoya, Japan; Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 6 Prognostic Value of Myogenic Differentiation in Dedifferentiated Liposarcoma (42) Ivan Chebib, Pawel Kurzawa, John T Mullen, Sarah E Johnstone, Vikram Deshpande, G Petur Nielsen. Massachusetts General Hospital and Harvard Medical School, Boston, MA; Poznan University of Medical Sciences, Poznan, Poland. 7 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma (ALT/WDL) and Dedifferentiated Liposarcoma (DDLPS): An Institutional Study of 81 Cases Focusing on the Sclerosing Pattern (76) Kyle D Perry, Karen Fritchie. Mayo Clinic, Rochester, MN. 8 Gene Expression Profiling as a Diagnostic Adjunct for Liposarcoma (50) Evita Henderson-Jackson, Yin Xiong, Anthony Magliocco, Soner Altiok. Moffitt Cancer Center, Tampa, FL. 9 Adrenal Schwannomas: A Clinicopathologic Study with Identification of a Peculiar Hybrid Schwannian/ Neuroendocrine Adrenal Medullary Tumor (75) Kyle D Perry, Andrew L Folpe, Andrew E Horvai, Michael Michal, Michal Michal, Lester DR Thompson, Gretchen Galliano, Ali G Saad, Richard Trepeta, Jorge Torres-Mora. Mayo Clinic, Rochester, MN; Charles University Hospital Plzen, Plzen, Czech Republic; Woodland Hills Medical Center, Woodland Hills, CA; D. of Pathology, S.F., CA; Ochsner Medical Center, New Orleans, LA; UMC, Jackson, MS; St. Joseph s Hospital, Phoenix, AZ. 10 Glandular Malignant Peripheral Nerve Sheath Tumors with Neoplastic Epithelium: A Unique and Diagnostically Challenging Biphasic Neoplasm (38) Melissa M Blessing, Mark E Jentoft, Jorge Torres-Mora. Mayo Clinic, Rochester, MN. 193

254 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 11 BUB1B and PBK as Novel Markers in the Diagnosis of Malignant Peripheral Nerve Sheath Tumors (57) Meghan Kapp, Hilary Nickols, Justin MM Cates. Vanderbilt University Medical Center, Nashville, TN; Norton Brownsboro Hospital, Louisville, KY. 12 Specificity of H3K27Me3 Loss in Malignant Peripheral Nerve Sheath Tumors (73) Melike Pekmezci, Areli K Cuevas-Ocampo, Arie Perry, Andrew E Horvai. University of California San Francisco, San Francisco, CA. 13 STAT6 Immunohistochemical Staining in Solitary Fibrous Tumor and Histologic Mimics, a Single Institute Experience (82) Omer Saeed, Liang Cheng, Shanxiang Zhang, Shaxioang Chen. Indiana University school of Medicine, Indianapolis, IN. 14 Clinicopathological Prognostic Indicators of Solitary Fibrous Tumor (60) Jimin Kim, Yoonla Choi. Samsung Medical Center, Seoul, Republic of Korea. 15 PAX8 Expression by Solitary Fibrous Tumor: A Diagnostic Pitfall (95) David Ullman, Tiffany Graham, Shi Wei, Jennifer Gordetsky, Todd Stevens. University of Alabama at Birmingham, Birmingham, AL. 16 TERT Promoter Mutations in Solitary Fibrous Tumors (45) Elizabeth G Demicco, Khalida Wani, Davis R Ingram, Alexander J Lazar, Wei-Lien Wang. Mount Sinai Medical Center, New York, NY; The University of Texas MD Anderson Cancer Center, Houston, TX. 17 Synovial Sarcoma of Peripheral Nerves: Analysis of 14 Cases (34) John Aranake-Chrisinger, Behrang Amini, Lars-Gunnar Kindblom, Magnus Hansson, Jeanne M Meis. UT MD Anderson Cancer Center, Houston, TX; Royal Orthopaedic Hospital, Birmingham, United Kingdom; Sahlgrenska Hospital, Göteborg, Sweden. 18 Prognostic Features in Uniformly Treated Synovial Sarcoma (62) Ana B Larque, Vikram Deshpande, G Petur Nielsen, Ivan Chebib. Massachusetts General Hospital, Boston, MA. 19 A Novel CRTC1-SS18 Gene Fusion in an Undifferentiated Round Cell Sarcoma- Ewing- Like Sarcoma or Poorly Differentiated Synovial Sarcoma- A Diagnostic Dilemma (87) VP Sumathi, Abdullah Alholle, Angela Niblet, Cristina R Antonescu, Farida Latif. Royal Orthopaedic Hospital, Birmingham, United Kingdom; University of Birmingham, Birmingham, United Kingdom; Memorial Sloan-Kettering Cancer Center, New York, NY. 20 Desmoplastic Small Round Cell Tumors (DSRCT) with Atypical Presentations: A Report of 26 Cases (31) Alyaa Al-Ibraheemi, Cory Broehm, Munir R Tanas, Andrew E Horvai, Brian P Rubin, Alison L Cheah, Andrew L Folpe, Karen Fritchie. Boston Childrens Hospital, Boston, MA; Mayo Clinic, Rochester, MN; University of Iowa, Iowa city, IA; UCSF, San Francisco, CA; Cleveland Clinic, Cleveland, OH; Douglass Hanly Moir, New South Wales, Australia. 21 Whorling Cellular Perineurioma: An Undescribed Variant Mimicking Monophasic Fibrous Synovial Sarcoma (69) Michael Michal, Dmitry V Kazakov, Abbas Agaimy, Kvetoslava Michalova, Faruk Skenderi, Semir Vranic, Michal Michal. Charles University, Medical Faculty and Charles University Hospital Plzen, Plzen, Czech Republic; Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany; Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegowina. 22 Fibroblastic Reticular Cell Tumor (Cytokeratin-Positive Interstitial Reticulum Cell Tumor): A Series of 6 Cases with Emphasis on Extra-Nodal Presentation (59) Darcy A Kerr, Francisco Vega, Andrew E Rosenberg. University of Miami Miller School of Medicine, Miami, FL. 23 PTEN Hamartoma of Soft Tissue (PHOST): A Case Series with Immunohistochemical Evaluation (49) Joshua A Hanson, Lori Ballinger, Shawnia Ryan, Therese Bocklage. University of New Mexico School of Medicine, Albuquerque, NM; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM. 24 Primary Breast Sarcomas: Clinico-Pathological Study of 16 Cases (92) Jen-Wei Tsai, Lei Huo, Samia Khan, Khalida Wani, Alexander J Lazar, Wei-Lien Wang. EDA Hospital, Kaohsiung, Taiwan; The University of Texas MD Anderson Cancer Center, Houston, TX. 25 Differential Expression of Specific Skeletal Muscle Markers in a Series of 300 Rhabdomyosarcomas, Including Various Subtypes (80) Bharat Rekhi, Chhavi Gupta, Girish Chinnaswamy, Tushar Vora, Sajid Qureshi, Jyoti Bajpai, Nehal Khanna, Siddhartha Laskar. Tata Memorial Centre, Mumbai, Maharashtra, India; Tata Memorial Centre, Mumbai, Maharshtra, India; Tata Memorial Centre, Mumbai, Mahrashtra, India. 26 Claudin-4 Expression Distinguishes SWI/SNF Complex- Deficient Undifferentiated Carcinomas from Sarcomas (84) Inga-Marie Schaefer, Abbas Agaimy, Jason L Hornick, Christopher DM Fletcher. Brigham and Women s Hospital, Harvard Medical School, Boston, MA; University Hospital Erlangen, Erlangen, Germany. 194

255 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 27 Clinico-Pathologic Study of ATRX and Notch Receptor Expression in a Large Series of Angiosarcomas (72) Gauri Panse, Davis R Ingram, Samia Khan, Khalida Wani, Alexander J Lazar, Wei-Lien Wang. The University of Texas M D Anderson Cancer Center, Houston, TX. 28 Inflammatory Myofibroblastic Tumor: Expanding the Spectrum of ALK Fusion Partners (88) David Swanson, Andrew Wong, George Charames, Jeffery J Tanguay, Rita A Kandel, Brendan C Dickson. Mount Sinai Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; Lunenfeld- Tanenbaum Research Institute, Toronto, ON, Canada; Peterborough Regional Health Centre, Peterborough, ON, Canada. BREAST PATHOLOGY 29 Presence of Intra-Ductal Papillomas in Benign Breast Tissue and the Risk of Subsequent Breast Cancer in African American Women (175) Kinda Hayek, Sudeshna Bandyopadhyay, Julie J Ruterbusch, Michele L Cote, Baraa Alosh, MHD Fayez Daaboul, Rahman Chaudhary, Eman Abdulfatah, Marcel T Ghanim, Vishakha Pardeshi, Daniel W Visscher, Rouba Ali-Fehmi. WSU/DMC, Detroit, MI; Karmanos Cancer Center, Detroit, MI; Mayo Clinic, Rochester, MN. 30 Metabolomic Profiling Reveals Upregulated Fatty Acid Metabolism in Ductal Breast Cancers from African- American Women (193) Farhan Khan, Yasmine Kanaan, Robert L Copeland Jr, Delisha Stewart, Tammey J Naab. Howard University, Washington, DC; RTI International, Research Triangle Park, NC. 31 Strong Expression of HSP27, HSP60 and BCL2 Associated with Luminal Subtypes of Breast Ductal Carcinomas in African American Women (192) Farhan Khan, Yasmine Kanaan, Luisel J Ricks-Santi, Rabia Zafar, Tammey J Naab. Howard University, Washington, DC; Hampton University, Hampton, VA. 32 Breast Cancer Subtype Subsequent to a Benign Breast Biopsy Among African Americans (113) Sudeshna Bandyopadhyay, Eman Abdulfatah, Baraa Alosh, MHD Fayez Daaboul, Marcel T Ghanim, Julie J Ruterbusch, Julie Boerner, Michele L Cote, Rouba Ali- Fehmi. WSU, Detroit, MI. 33 Presence of Cysts in Benign Breast Tissue and the Risk of Subsequent Breast Cancer in African American Women (139) MHD Fayez Daaboul, Sudeshna Bandyopadhyay, Julie J Ruterbusch, Michele L Cote, Baraa Alosh, Eman Abdulfatah, Marcel T Ghanim, Daniel W Visscher, Rouba Ali-Fehmi. WSU, Detroit, MI; Mayo Clinic, Rochester, MN. 34 Patterns of Recurrence in African-American Women with Luminal A and Luminal B Subtype Breast Cancer A Single Institution Experience (186) Geetha Jagannathan, Juan P Palazzo. Thomas Jefferson University, Philadelphia, PA. 35 Palpable Breast Masses in a Tertiary Institution in South-South Nigeria; Fine Needle Aspiration Cytology versus Histopathology: A Correlation of Diagnostic Accuracy (253) Solomon Raphael, Stephen I Musa. University of Port-Harcourt Teaching Hospital, Port- Harcourt, Nigeria. 36 Estrogen Receptor-Positive/HER2-Negative and Lymph Node-Negative Breast Cancers Have Similar Oncotype DX Recurrence Score Distribution and Prognosis in African American and Caucasian Patients (217) Suzanna J Logan, Chao Zhang, Yuan Liu, Momin T Siddiqui, Cynthia Cohen, Xiaoxian Li. Emory University, Atlanta, GA. 37 ADH, the Precursor to Low Grade DCIS: Is It Time to Consider Active Surveillance for Patients Diagnosed with ADH on Core Needle Biopsy? (119) Julie Anne Bishop, Marie Hensley, Mary Ann Sanders. University of Louisville, Louisville, KY. 38 Atypical Hyperplasia of the Breast on Core Biopsy: Histologic Features Associated with Increased Risk of Upgrade to Carcinoma on Excision (149) Alana R Donaldson, Caitlin McCarthy, Valentina Avkshtol, Shazia Goraya, Holly J Pederson, Charles D Sturgis, Stephen R Grobmyer, Benjamin C Calhoun. Cleveland Clinic, Cleveland, OH. 39 Spectrum of Pathologic Findings in Breast Biopsy for MRI-Detected Non-Mass-Like Enhancement (302) Zhaohai Yang. Penn State Hershey Medical Center, Hershey, PA. 40 Histological Findings in Benign Breast Biopsies After Tamoxifen Therapy for Breast Cancer (264) Rosalind Sandell, Tanya Hoskin, Marlene Frost, Amy Degnim, Daniel W Visscher. Mayo Clinic, Rochester, MN. 41 Loss of DEEBC Expression Is Lost Early in Breast Cancer Development (163) Yesim Gokmen-Polar, Maria Zavodszky, Xiaowei Chen, Xiaoping Gu, Chinnappa Kodira, Sunil Badve. Indiana University School of Medicine, Indianapolis, IN; GE Global Research, Niskayuna, NY. 42 Discordant HER2 Immunohistochemical Expression and Gene Amplification by In-Situ Hybridization in Ductal Carcinoma In Situ (295) Hai Wang, Yiang Hui, Murray B Resnick, Yihong Wang. Brown University, Providence, RI. 195

256 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 43 Clinicopathological Characteristics of 815 Ductal Carcinoma In Situ (DCIS) from the BONBIS Trial Focus on the HER2 Positive Group (248) Frederique Penault-Llorca, Lucie Tixier, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Nina Robin-Radosevic, Catherine Abrial, Anne Cayre, David Azria. Centre Jean Perrin, Clermont Ferrand, France; Institut Paoli Calmettes, Marseille, France; Centre Jean Perrin, Clermont Ferrand, France; Institut de Cancérologie de Montpellier, Montpellier, France. 44 Mammary and Extra-Mammary Paget s Disease- An Institutional Experience (156) Ramya Gadde, Dhananjay Chitale. Henry Ford Hospital, Detroit, MI. 45 Whole Transcriptome Analysis Identifies Upregulated Genes and Pathways Differentially Expressed in Ductal Carcinoma In Situ Mimicking Usual Ductal Hyperplasia (306) Jennifer Zeng, Jonathan Serrano, Matija Snuderl, Farbod Darvishian. New York University Medical Center, New York, NY. 46 Clinico-Pathological Features of Breast Cancer Patients; Is It Different in an HIV Endemic Sub Saharan African Country- Botswana Experience (235) Mohan Narasimhamurthy, Surbhi Groover. University of Botswana, Gaborone, Botswana. 47 Missing Targets After Nipple-Sparing Mastectomy: A Multidisciplinary Approach to Avoid an Undesirable Outcome (305) Jennifer Zeng, Cecilia L Mercado, Farbod Darvishian. New York University Langone Medical Center, New York, NY. 48 Utilizing Digital Specimen Tomography Improves Lesion Identification, Tumor Assessment, and Efficacy of Grossing of Breast Excision Specimens (170) Lisa Han, Xiao Han, Xiaochuan Pan, Kirti M Kulkarni, Jeffrey Mueller. University of Chicago, Chicago, IL. 49 Occult Malignancy in Risk Reduction Bilateral Mastectomies from Women with BRCA1 or BRCA2 Germline Mutation: Correlation with Imaging Abnormalities and Implications for Specimen Sampling Strategies (171) Lucy Han, Yunn-Yi Chen, Gregor Krings, Julie Mak, Joseph T Rabban. UCSF, San Francisco, CA. 50 Bilateral Prophylatic Mastectomy A 5 Years Study from a Single Institution (249) Daniela Pereira, Sara Câmara, Beatriz Mira, Fátima Vaz, Saudade Andre. Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Lisbon, Portugal. 51 Prognostic Importance of Ki-67 Assessment in Residual Invasive Breast Carcinoma Following Neoadjuvant Chemotherapy: A Study of 106 Patients with Follow-Up (128) Esther Cheng, David Ko, Tracy-Ann Moo, Zhengming Chen, Sandra Demaria, Eleni Andreopoulou, Timothy D Alfonso. Weill Cornell Medicine, New York, NY. 52 Cost Effectiveness of Intraoperative Examination of Sentinel Lymph Nodes in Patients with DCIS Compared to Invasive Breast Carcinoma (270) Eugene T Shin, Amy S Joehlin-Price, Debra L Zynger. The Ohio State University Wexner Medical Center, Columbus, OH; University of California San Francisco Medical Center, San Francisco, CA. 53 Digital Analysis of Tumour Microarchitecture as an Independent Prognostic Tool in Breast Cancer (260) Ioannis Roxanis, Richard Colling, Emad A Rakha, Andrew Green, Jens Rittscher, Raquel C Conceição, Aidan Ross, George Nicholson, Chris Holmes. Oxford University Hospitals NHS Foundation Trust and NIHR Biomedical Research Centre, Oxford, United Kingdom; University of Oxford, Oxford, United Kingdom; University of Nottingham, Nottingham, United Kingdom. 54 Correlating Infrared Imaging Based Automated Breast Tumor Staging Models with Immunohistochemical (IHC) Stained Images (230) Shachi Mittal, Andre Kadjacsy-Balla, LSuzanne Leslie, Rohit Bhargava. University of Illinois at Urbana- Champaign, Urbana, IL; University of Illinois at Chicago, Chicago, IL. 55 Intra-Tumoral Injection of Acetic Acid and Ethanol Causes Tumor Regression of Human Breast Cancer in Xenograft Murine Model (292) Neha Varshney, Sayee Kiran, Jasneet S Bhullar, Christopher Bergum, Melissa Decker, Jefferey Flynn, Vasuki Anandan, Vijay Mittal. University of Toledo Medical Center, Toledo, OH; Providence Hospital and Medical Center, Southfield, MI. 56 Potential Role of Desorption Electrospray Ionization (DESI) Mass Spectrometry Imaging (MSI) as an Adjunct to Histology for Margin Assessment in Lumpectomies for Breast Cancer (256) Kevin Yi Mi Ren, Martin Kaufmann, Nicole Morse, Amanda Shuo Xu, John Rudan, David Berman, Sonal Varma. Queen s University, Kingston, ON, Canada; Queen s Unversity, Kingston, ON, Canada. 57 Clinical Impact of Second Opinion on Lesions of the Breast and Axillary Region (222) Vicente Marco, Felip Garcia Hernandez, Isabel T Rubio. Hospital Quironsalud Barcelona, Barcelona, Spain. 196

257 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 58 The Prognostic Impact of Synchronous Ipsilateral Multiple Breast Cancer (130) Jinah Chu, Hyunsik Bae, Seok-Hyung Kim, Eun Yoon Cho. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 59 Next-Generation Sequencing Profiling of Circulating Tumor Cells in Metastatic Breast Cancer Patients Reveals Mutational Heterogeneity (123) Andi Cani, Costanza Paoletti, Kimberly Aung, Elizabeth P Darga, Emily M Cannell, Daniel H Hovelson, Maryam Yazdani, Allen R Blevins, Nahomi Tokudome, Paul Baratta, Jose M Larios, Dafydd G Thomas, Marty E Brown, Christina Gersch, Anne F Schott, Daniel Robinson, Arul M Chinnaiyan, Farideh Bischoff, Daniel F Hayes, James M Rae, Scott A Tomlins. University of Michigan, Ann Arbor, MI; Silicon Biosystems Inc., San Diego, CA. DERMATOPATHOLOGY 60 The Incidence of Radiotherapy-Induced Angiosarcoma in the Skin After Treatment for Breast Cancer in Denmark. A Population-Based Study (517) Katalin Kiss, Simon Andreasen, Maj-Lis M Talman, Søren Daugaard, Thomas Mentzel. Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Dermatopathology, Friedrichshafen, Germany. 61 Cutaneous Kaposi Sarcoma in Non-AIDS Related Immunosuppressed Patients: A Histologic Study of Morphologic Spectrum (494) Afaf Alsolami, Hatim Khoja, Shamayel Mohammed, Fouad Aldayel, Tariq Al-Zaid. King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. 62 Expanding the Molecular Diversity of Epithelioid Fibrous Histiocytoma (538) David Swanson, Andrew Wong, George Charames, David J Howarth, Rita A Kandel, Brendan C Dickson. Mount Sinai Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; Lunenfeld- Tanenbaum Research Institute, Toronto, ON, Canada. 63 The Application of COL1A1-PDGFB Fusion Gene Detection by Fluorescence In Situ Hybridization in Biopsy Tissue of Dermatofibrosarcoma Protuberans (542) Zhang Zhang, Huijiao Chen, Min Chen, Xin He, Yiying Wang, Hongying Zhang. West China Hospital, Sichuan University, Chengdu, Sichuan, China. 64 Evaluation of p16 Protein Expression and CDKN2A Deletion in Conventional and Fibrosarcomatous Dermatofibrosarcoma Protuberans (536) Andrew Siref, Vatsal Patel, John D Reith, Bonnie Balzer, Wonwoo Shon. Cedars-Sinai Medical Center, Los Angeles, CA; University of Florida, Gainesville, FL. 65 Primary Cutaneous Solitary Fibrous Fumor (SFT) A Series of 23 Cases (500) Patrick Feasel, Alyaa Al-Ibraheemi, Karen Fritchie, Wei- Lien Wang, Elizabeth G Demicco, Marcela Saeb Lima, Jennifer Ko, John R Goldblum, Brian P Rubin, Jesse K McKenney, Steven Billings. Cleveland Clinic Foundation, Cleveland, OH; Boston Children s Hospital, Boston, MA; El Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico DF, Mexico; Mayo Clinic, Rochester, MN; Mount Sinai Hospital, Manhattan, NY; MD Anderson Cancer Center, Houston, TX. 66 Primary Cutaneous CIC-DUX Sarcoma: A Report of Two Cases (519) Jennifer Ko, Zlatko Marusic, Yu-Wei Cheng, Rajiv Patel, Brian P Rubin, Steven Billings. Cleveland Clinic, Cleveland, OH; University Hospital Centre, Zagreb, Croatia; University of Michigan, Ann Arbor, MI. 67 Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes (518) Jennifer Ko, Balwir Matharoo-Ball, Steven Billings, Brian Thomson, Jean Tang, Kavita Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Kimbrell, Darl Flake, M Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard Wenstrup, Loren Clarke. The Cleveland Clinic, Cleveland, OH; Nottingham University, Nottingham, United Kingdom; Stanford University, Redwood City, CA; Myriad Genetic Laboratories, Inc., Salt Lake City, UT. 68 Diagnosis of Spitz Tumors in Children and Adults Using Artificial Neural Networks (507) Julien Henriet, Christine Monnin, Johanna Clerc, Brigitte Chebel Morello, Nourredine Zehrouni. Laboratoire Femto st UMR 6174 CNRS, Besancon, France; North Franche Comte Hospital, Belfort, Franche Comte, France. 69 Diagnosis of Spitz Tumor Using Artificial Neural Networks (508) Julien Henriet, Christine Monnin, Johanna Clerc, Nourredine Zehrouni. CNRS UMR 6174, Besancon, Franche Comte, France, Metropolitan; North Hospital Franche Comte, Belfort, Franche Comte, France, Metropolitan. 197

258 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 70 Basal Cell Carcinoma with Matrical Differentiation: Clinicopathological, Immunohistochemical and Molecular Biological Study of 22 Cases (522) Liubov Kyrpychova, Richard A Carr, Petr Martinek, Tomas Vanecek, Raul Perret, Magdalena Chottová- Dvořáková, Alex Lazar, Michal Zamecnik, Michal Michal, Dmitry V Kazakov. Charles University in Prague, Pilsen, Czech Republic. 71 Genetic Alteraions in Lesions of Anogenital Mammary- Like Glands and Their Mammary Counterparts (520) Anastasia M Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Denisa Kacerovska, Michal Michal, Dmitry V Kazakov. Clinical and Research Oncological Center, St- Petersburg, Russian Federation; Bioptical Laboratory, Pilsen, Czech Republic; Charles University in Prague, Pilsen, Czech Republic. 72 Spectrum of Changes in Anogenital Mammary-Like Glands (AGMLG) in Primary Extramammary Paget Disease (EMPD) (521) Anastasia M Konstantinova, Dominic V Spagnolo, Colin J Stewart, Denisa Kacerovska, Ksenya V Shelekhova, Jose A Plaza, Saul Suster, Jiri Bouda, Liubov Kyrpychova, Michal Michal, Irena E Belousova, Katrin Kerl, Dmitry V Kazakov. Research and Practical Oncological Center, Saint- Petersburg, Russian Federation; Saint-Petersburg State University, Saint-Petersburg, Russian Federation; Charles University in Prague, Pilsen, Czech Republic; Bioptical Laboratory, Pilsen, Czech Republic. 73 PD-L1 and c-myc Status in Merkel Cell Carcinoma: An Immunohistochemical and mrna Chromogenic In Situ Hybridization Study (505) Eva George, Bonnie Balzer, David Frishberg, Xiamon Lu, Wonwoo Shon. University of Florida College of Medicine, Gainesville, FL; Cedars-Sinai Medical Center, Los Angeles, CA. 74 SATB2 Expression in Merkel Cell Carcinomas: An Immunohistochemical Study of 165 Cutaneous Neoplasms (504) Joseph S Frye, Namrah Aijaz, Bonnie Balzer, David Frishberg, Wonwoo Shon. Cedars-Sinai Medical Center, Los Angeles, CA; University of Florida College of Medicine, Gainesville, FL. 75 Frequent Loss of T-Cell Receptor-Beta (TCRβ) Expression at Transformation in Mycosis Fungoides (MF/SS) (512) Balaji Jothishankar, Girish Venkataraman, Farah Abdulla. University of Chicago Medical Center, Chicago, IL. 76 T-Cell Receptor (TCR) Gene Rearrangement Profiles in Skin Biopsy of Mycosis Fungoides (499) Hongxin Fan, Kumari Vadlamudi, Yao Wang, Marsha C Kinney. University of Texas Health Science Center at San Antonio, San Antonio, TX. GASTROINTESTINAL PATHOLOGY 77 Morphological and Molecular Features of Gastric Glomus Tumors (840) Dongwei Zhang, Sarawut Kongkarnka, Elena V Komissarova, Armando Del Portillo, Antonio G Neto, Jorge Sepulveda, Antonia Sepulveda. Columbia University Medical Center, New York, NY; NYU Langone Medical Center, New York, NY. 78 Metachronous and Synchronous Gastric Neoplasm After Endoscopic Treatment of Gastric Epithelial Dysplasia: Impact of Intestinal Metaplasia and Crypt Dysplasia of Background Mucosa (771) Won-young Park, Do Youn Park, Kyung Un Choi, Gi Young Huh, Chang Hun Lee, Ahrong Kim, Young Keum Kim, So Jeong Lee, Chung Su Hwang. Hanmaeum Changwon Hospital, Changwon, Gyeongsangnam-do, Republic of Korea; Pusan National University Hospital, Busan, Seo-Gu, Republic of Korea. 79 Molecular Profiling of Dysplasia Subtypes in Inflammatory Bowel Disease: A Comparative Analysis with Sporadic Precursors of Colorectal Carcinoma (785) Elizabeth M Rinehart, Jonathan A Nowak, Neal I Lindeman, John R Goldblum, Robert D Odze, Deepa T Patil. Brigham and Women s Hospital, Boston, MA; Cleveland Clinic, Cleveland, OH. 80 Immunohistochemical Testing of Biopsy Specimens Is Warranted in Lynch Syndrome Screening (682) Jennifer J Findeis-Hosey, Karina Hiroshige, Bibiana Steinbauer. Univ. of Rochester Med. Ctr., Rochester, NY; University of Florida COM, Jacksonville, FL. 81 Constrictive Strictures in Crohn s Ileitis (844) Xiaofei Zhang, Huai-Bin Mabel Ko, Zhenjian Cai, Hongfa Zhu, Alexandros D Polydorides, Noam Harpaz. Icahn School of Medicine at Mount Sinai, New York, NY. 82 The Clinical Significance of Active Colitis Following the Advent of Immunomodulator Therapy and Availability of PCR Based Microbiological Detection Panels (718) Heewon Kwak, Scott Matushek, Vera Tesic, Shu-Yuan Xiao, John Hart, Namrata Setia. University of Chicago, Chicago, IL. 83 Examination of Lymph Node Status in Gastroenteropancreatic Neuroendocrine Tumors (651) Luis Carrillo-Polanco, Peter N Bonneau, Christopher Hartley, Catherine Hagen. Medical College of Wisconsin, Milwaukee, WI; University of Wisconsin Hospital and Clinics, Madison, WI. 198

259 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 84 Tubulovillous Adenomas with Serrated Features Are Precursors to KRAS Mutant Colorectal Carcinoma (621) Amrou Abdelkader, Christopher Hartley, Catherine Hagen. Medical College of Wisconsin, Milwaukee, WI; University of Wisconsin Hospital and Clinics, Madison, WI. 85 Interobserver Variability of Histopathological Regression Scoring Systems Following Neoadjuvant Chemo-Radiotherapy in Esophageal Cancer (794) Paromita Roy, Sayali N Honap, Indu Arun, Robin Thambudorai, Indranil Mallick. Tata Medical Center, Kolkata, West Bengal, India. 86 Prevalence of Immunohistochemically Demonstrable Helicobacter Pylori in Biopsies without Histologic Evidence of Gastritis (624) Andres Acosta, Michael R Pins. University of Illinois at Chicago, Chicago, IL; Chicago Medical School, Chicago, IL; Advocate Lutheran General Hospital, Park Ridge, IL. 87 Anal Canal Adenocarcinoma with Associated Perianal Paget s Disease: An Underrecognized Entity with Institutional Experience (815) Sarah C Thomas, Carolina Dominguez Marquez, Cory Porteus, Kun Jiang. Moffitt Cancer Center, Tampa, FL; University of South Florida, Tampa, FL. 88 Tumor Buds and Micropapillae in Colorectal Carcinoma Demonstrate Similarities in Biological Behavior and May Represent Two Ends of the Same Spectrum (820) Monika Vyas, Romulo Celli, Xuchen Zhang. Yale School of Medicine, New Haven, CT. 89 Characterization of Lgr5 Expression in Colorectal Neuroendocrine Tumor (758) Tomoyuki Nakajima, Takeshi Uehara, Yasuhiro Maruyama, Yukihiro Kobayashi, Hiroyoshi Ota, Takayuki Honda. Shinshu University School of Medicine, Matsumoto, Japan. 90 APC and KRAS Genetic Variants Associated with Colorectal Cancer Histology Grade and Tumor Staging (842) Wei Zhang, Kyle Gettler, Aneta Waluszko, Tatyana Sidorenko, Gordana Katava, David Zhang, Fei Ye. Mount Sinai Health System, New York, NY; Yale University School of Medicine, New Haven, CT. 91 Crypt Apoptosis Contributes to Mucosal Flattening in Celiac Disease Patients When Exposed to Dietary Gluten (723) Michael Lee, Alina Iuga, Hui-Min Yang, Jude Fleming, Peter HR Green, Benjamin Lebwohl, Stephen M Lagana. Columbia University, New York, NY. 92 Prognostic Impact of Grade and MSI Status in Mucinous Colorectal Cancers (828) David Williams, Marsali Newman, Elham Amini, David Nickless, Catherine Fang, Robert Jorissen, Oliver Sieber. Austin Health, Melbourne, Victoria, Australia; Sonic Healthcare, Perth, Western Australia, Australia; Australian Clinical Labs, Melbourne, Victoria, Australia; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia; Walter and Elisa Hall Institute of Medical Research, Melbourne, Victoria, Australia. 93 Immune Infiltrates Confer Prolonged Survival in Colorectal Cancer with Microsatellite Instability (827) David Williams, Marsali Newman, Elham Amini, David Nickless, Catherine Fang, Robert Jorissen, Oliver Sieber. Austin Health, Melbourne, Victoria, Australia; Sonic Healthcare, Perth, Western Australia, Australia; Australian Clinical Labs, Melbourne, Victoria, Australia; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia; Walter and Elisa Hall Institute of Medical Research, Melbourne, Victoria, Australia. 94 EZH2 as a Useful Diagnostic Tool for Grading Gastrointestinal (GI) Neuroendocrine Tumors (707) Rajeswari Jayakumar, Jia Qin, MA Siddiqi, Raavi Gupta. SUNY Downstate Medical Center, Brooklyn, NY; Massachusetts General Hospital, Boston, MA. 95 Duodenal Neoplasm of Gastric Phenotype: An Immunohistochemical and Genetic Study with a Practical Approach to the Classification (838) Hidetaka Yamamoto, Risa Hida, Minako Hirahashi, Toshihiro Gi, Yoshinao Oda. Kyushu University, Fukuoka, Japan; University of Miyazaki, Miyazaki, Japan. 96 Gene Profiling of Precursor Serrated Polyps and Associated Carcinoma Using Next Next Generation Sequencing (802) Stefano Serra, Matthew Seto, Tong Zhang, Sangeetha N Kalimuthu, Suzanne Kamel-Reid, Runjan Chetty. University Health Network, University of Toronto, Toronto, ON, Canada. 97 Epidemiologic Evaluation of Biopsies Performed for Potential Gastrointestinal GVHD (650) David Carr, Grace Y Lin, Mojgan Hosseini. UC San Diego, San Diego, CA. 98 Challenges in Equivocal Score (2+) HER2 Results for Gastric/Gastroesophageal Junction Adenocarcinomas (691) Shaheed W Hakim, Hala Faragalla, Kiran Jakate, Catherine Streutker. St. Michael s Hospital, Toronto, ON, Canada. 199

260 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 99 Yield of Universal Testing for Mismatch Repair Protein Deficiency in 2077 Colorectal Carcinomas (793) Christophe Rosty, Gregory Miller, Mark Bettington, Ian Brown. Envoi Pathology, Brisbane, Australia; University of Queensland, Brisbane, Australia. 100 Mismatch Repair System Molecule Immunophenotype and BRAF V600E Genotype of PD-L1-Positive Primary and Metastatic Colorectal Carcinomas (702) Shingo Inaguma, Anna Felisiak-Golabek, Zengfeng Wang, Jerzy Lasota, Markku M Miettinen. Aichi Medical University, Nagakute, Aichi, Japan; National Institutes of Health, Bethesda, MD. 107 Histologic Features of Mismatch Repair (MMR) Deficiency Do Not Reliably Predict Immunohistochemical Detection of MMR Deficiency in Colorectal Carcinoma: The Results of a 5-Year Prospective Evaluation (768) Dane Olevian, Reetesh Pai. University of Pittsburgh Medical Center, Pittsburgh, PA. 108 Lymphocytic Gastritis: Clinicopathologic Associations, Old and New (781) Maryam Pezhouh, James A Miller, Danielle Hutchings, Maryam Shabihkhani, Ogechukwu Pearl Eze, Lysandra Voltaggio, Elizabeth A Montgomery. Johns Hopkins Hospital, Baltimore, MD. 101 MSH3 and EMAST in Inflammatory Bowel Disease- Associated Dysplasia and Carcinoma (744) Alexander Maris, Frank Revetta, Chanjuan Shi. Vanderbilt University Medical Center, Nashville, TN. 102 Low Grade Appendiceal Mucinous Neoplasms with Neoplastic Epithelium Confined to the Appendix: 45 Cases with Clinical Follow-Up (637) Brad D Barrows, Deepti Dhall. Cedars Sinai Medical Center, Los Angeles, CA. 103 Risk Factors of Lymph Node Metastasis in T1 Colorectal Cancer: Tumor Budding Is a Reliable Pathologic Indicator Than Depth of Submucosal Invasion (724) So Jeong Lee, Do Youn Park, Kyung Un Choi, Gi Young Huh, Chang Hun Lee, Ahrong Kim, Young Keum Kim, Chung Su Hwang. Pusan National University Hospital, Busan, Seo-Gu, Republic of Korea. 104 Can Metastatic Lobular Carcinoma Be Reliably Distinguished from Diffuse-Type Gastric Adenocarcinoma? (664) Lani K Clinton, Thomas Plesec, John R Goldblum, Kaveh Hajifathalian, Deepa T Patil. Cleveland Clinic, Cleveland, OH. 105 Detection of Clonal Evolution in Solid Tumors by Ultra- Deep Sequencing of Plasma Cell-Free Nucleic Acid Using Miseq (749) Meenakshi Mehrotra, Rajesh R Singh, Wei Chen, Bedia A Barkoh, Carmen Behrens, Keyur P Patel, Mark J Routbort, Russell R Broaddus, L J Medeiros, Scott Kopetz, Ignacio I Wistuba, Rajyalakshmi Luthra. The University of Texas MD Anderson Cancer Center, Houston, TX. 106 Clinical and Pathologic Features of Gastrointestinal Rosai Dorfman Disease (812) Yaman Tarabishy, Ogechukwu Pearl Eze, Kevin Waters, Lysandra Voltaggio, Elizabeth A Montgomery, Maryam Pezhouh. The Johns Hopkins Hospital, Baltimore, MD. 109 Incidence and Prognosis of Extramural Venous Invasion in Small Intestine Neuroendocrine Tumors (731) Qingqing Liu, Huai-Bin Mabel Ko, Hongfa Zhu, Noam Harpaz, Alexandros D Polydorides. Ichan School of Medicine at Mount Sinai, New York, NY. 110 Harnessing TCGA RNAseq Data as a Springboard to Novel Tumor Markers (708) William Richard Jeck, Kshitij S Arora, Elena Brachtel, Vikram Deshpande. Massachusetts General Hospital, Boston, MA. 111 Adenocarcinoma Ex-Goblet Cell Carcinoid of the Appendix Is a Tumor of Intestinal Lineage and Mucinous Differentiation (787) Brian Robinson, Bahar Memis, Andy Toussaint, Yue Xue, Alyssa Krasinskas, Charles Staley, Joshua H Winer, Maria C Russell, Walid Shaib, Bassel El-Rayes, Volkan Adsay, Michelle D Reid. Emory, Atlanta, GA. 112 Unique Prognostic Significance of CD206 and CD163 Macrophage Subtype Markers in Esophageal Adenocarcinoma (649) Wenqing Cao, Margaret A Black, Jiangzhou Yu. New York University Langone Medical Center, New York, NY; University of Illinois at Chicago, Chicago, IL. 113 Histopathology of Chronic Antibody-Mediated Rejection in Pediatric Liver Transplantation: Is Obliterative Portal Venopathy a Novel Finding? (690) Marjorie-Anne R Guerra, Laura J Wozniak, Jason V Scapa, Bita V Naini. UCLA, Los Angeles, CA. 114 Targeted Next-Generation Sequencing Supports Epidermoid Metaplasia of the Esophagus Is a Precursor to Esophageal Squamous Neoplasia (806) Aatur D Singhi, Christina A Arnold, Dora M Lam- Himlin, Marina N Nikiforova, Lysandra Voltaggio, Elizabeth A Montgomery. University of Pittsburgh Medical Center, Pittsburgh, PA; Ohio State University, Columbus, OH; Mayo Clinic, Scottsdale, AZ; Johns Hopkins Hospital, Baltimore, MD. 200

261 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Singapore Intestinal Metaplasia (SIM) Classification: MUC5AC Positive Immunophenotype and Multifocal Pattern Are Strong Predictors of Progression to Gastric Dysplasia (813) Ming Teh, Supriya Srivastava, Feng Zhu, Ting Ting Wang, Richie Soong, Khek Yu Ho, Khay Guan Yeoh, Manuel Salto-Tellez. National University Hospital, Singapore, Singapore; Cancer Science Institute, Singapore, Singapore; Queen s University, Belfast, Ireland. 116 IgG4-Related Disease of the Gastrointestinal Tract: A Tertiary Care Hospital Experience (660) Woo Cheal Cho, Saverio Ligato, Richard Cartun, Anshu Trivedi. Hartford Hospital, Hartford, CT. 117 Mutational Landscape of BRAF-Mutated Microsatellite- Stable Colorectal Cancer Shows High Prevalence of Concurrent TP53 Mutations (833) Elizabeth Yiru Wu, Fei Dong, Neal I Lindeman, Amitabh Srivastava. Brigham and Women s Hospital, Boston, MA. GENITOURINARY PATHOLOGY 118 What the Pathologist Needs to Know About the Role of Fumarate Hydratase in the Diagnosis of HLRCC Renal Cancer (982) Maria J Merino, Christopher Ricketts, Xu Naizhen, W Marston Linehan, Vanessa Moreno. NIH/NCI, Bethesda, MD. 119 Different Patterns of PD-1 and PD-L1 Expression in Histologic Subtypes of Renal Cell Carcinoma (RCC) Analysis of Data from the Cancer Genome Atlas (TCGA) Kidney Projects (1053) Yue Sun, Hikmat Al-Ahmadie, Anuradha Gopalan, Samson W Fine, Sahussapont J Sirintrapun, Satish K Tickoo, Victor E Reuter, Ying-Bei Chen. Memorial Sloan Kettering Cancer Center, New York, NY. 120 Comparison of 4 PD-L1 Antibodies in 560 Kidney, Bladder and Prostate Cancers (1062) Maria Tretiakova, Regan Fulton, Masha Kocherginsky, Nicole Andeen, Lawrence True, Allen M Gown. University of Washington, Seattle, WA; PhenoPath, Seattle, WA; Northwestern University, Chicago, IL. 121 Morphologic Analysis of Renal Cell Carcinoma, Unclassified (1004) Carmen Perrino, David Grignon, Muhammad Idrees, John N Eble, Liang Cheng. Indiana University, Indianapolis, IN. 122 Correlation of MET Complete Status and Outcome in Patients with Metastatic Clear Cell Renal Cell Carcinoma Treated by Sunitinib (946) Solene-Florence Kammerer-Jacquet, Sarah Medane, Karim Benasalah, Jean-Christophe Bernhard, Frantz Dupuis, Mokrane Yacoub, Alain Ravaud, Gregory Verhoest, Romain Mathieu, Benoit Peyronnet, Angelique Brunot, Brigitte Laguerre, Alexandra Lespagnol, Jean Mosser, Frédéric Dugay, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq. Hospital University, Rennes, France; Hospital University, Bordeaux, France; Centre Eugène Marquis, Rennes, France. 123 Nomogram Predicting Prognosis in Metastatic Patients with Clear Cell Renal Cell Carcinoma Treated by First- Line Sunitinib (948) Solene-Florence Kammerer-Jacquet, Frédéric Dugay, Karim Bensalah, Angelique Brunot, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Mathilde Lefort, Sahar Bayat, Alexandra Lespagnol, Jean Mosser, Julien Edeline, Brigitte Laguerre, Frantz Dupuis, Mokrane Yacoub, Alain Ravaud, Jean-Christophe Bernhard, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq. Hospital University, Rennes, France; Centre Eugene Marquis, Rennes, France; EHESP, Rennes, France; Hospital Universty, Bordeaux, France. 124 GATA-3 Is a Specific Marker for Clear Cell Papillary Renal Cell Carcinoma (975) Jose G Mantilla, Tatjana Antic, Maria Tretiakova. University of Washington, Seattle, WA; University of Chicago, Chicago, IL. 125 Primary Renal Soft Tissue Neoplasms in Nephrectomy Specimens Evaluated at a Single Institution (852) Fatimah I Alruwaii, Muhammad Idrees, Shaoxiong Chen. Indiana University School of Medicine, Indianapolis, IN. 126 Comparison of Targeted and Non-Targeted RNA-seq for Translocation RCC in FFPE Tissue (1025) Christian Salib, Weihua Huang, Konstantin Volyanskyy, Liying Han, Larisa Debelenko, Nevenka Dimitrova, John T Fallon, Minghao Zhong. Westchester Medical Center/ New York Medical College, Valhalla, NY; Philips Research North America, Briarcliff Manor, NY. 127 Acquired Cystic Disease-Associated Renal Cell Carcinoma (ACD-RCC): A Multi-Institutional Study with Clinical Follow Up (1012) Christopher Przybycin, Roni Cox, Angela Wu, Ankur Sangoi, Jesse K McKenney. Cleveland Clinic, Cleveland, OH; University of Arkansas for Medical Sciences, Little Rock, AR; El Camino Hospital, Mountain View, CA; University of Michigan Health System, Ann Arbor, MI. 201

262 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Validation of ISUP/WHO Grading of Clear Cell Renal Cell Carcinoma (884) Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, Geoff Coughlin, Nigel Dunglison, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, Hemamali Samaratunga. Aquesta Specialized Uropathology, Brisbane, Australia; Rennes University Hospital, Rennes, France; University of Rennes, Rennes, France; Wellington School of Medicine and Health Sciences, Wellington, New Zealand; University of Queensland, Brisbane, Australia; Karolinska Institute, Stockholm, Sweden; Wesley Hospital, Brisbane, Australia; Greenslopes Hospital, Brisbane, Australia; Holy Spirit Northside Hospital, Brisbane, Australia. 129 Necrosis and Tumor Grading in Clear Cell Renal Cell Carcinoma (886) Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, Geoff Coughlin, Nigel Dunglison, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, Hemamali Samaratunga. Aquesta Specialized Uropathology, Brisbane, Australia; Rennes University Hospital, Rennes, France; University of Rennes, Rennes, France; Wellington School of Medicine and Health Sciences, Wellington, New Zealand; University of Queensland, Brisbane, Australia; Karolinska Institute, Stockholm, Sweden; Wesley Hospital, Brisbane, Australia; Greenslopes Hospital, Brisbane, Australia; Holy Spirit Northside Hospital, Brisbane, Australia. 130 The Significance of the Percentage of High-Grade Carcinoma in Predicting Outcome in Clear Cell Renal Cell Carcinoma (885) Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, Geoff Coughlin, Nigel Dunglison, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, Hemamali Samaratunga. Aquesta Specialized Uropathology, Brisbane, Australia; Rennes University Hospital, Rennes, France; University of Rennes, Rennes, France; Wellington School of Medicine and Health Sciences, Wellington, New Zealand; University of Queensland, Brisbane, Australia; Karolinska Institute, Stockholm, Sweden; Wesley Hospital, Brisbane, Australia; Greenslopes Hospital, Brisbane, Australia; Holy Spirit Northside Hospital, Brisbane, Australia. 131 Non-Tumoral Parenchymal Changes in Renal Cell Carcinoma Cases (846) Behnoush Abedi-Ardekani, Lars Egevad, Roz Banks, James D McKay, Paul Brennan, Ghislaine Scelo. International Agency for Research on Cancer, Lyon, France; Karolinska Institute, Stockholm, Sweden; University of Leeds, Leeds, United Kingdom. 132 SWI/SNF Complex Alterations Are Uncommon in Fumarate Hydratase-Deficient Renal Cell Carcinoma: Immunohistochemical Analysis of 27 Tumors (848) Abbas Agaimy, Mahul B Amin, Anthony J Gill, Daniel Berney, Cristina Magi-Galluzzi, Mathilde Sibony, Steven C Smith, Saul Suster, Kiril Trpkov, Ondřej Hes, Arndt Hartmann. University Hospital of Erlangen, Erlangen, Germany. 133 Programmed Death-1 (PD-1) Receptor/PD-1 Ligand (PD- L1) Expression in Fumarate Hydratase-Deficient Renal Cell Carcinoma (849) Reza Alaghehbandan, Jan Stehlik, Kiril Trpkov, Cristina Magi-Galluzzi, Maria Pane Foix, Daniel Berney, Mathilde Sibony, Saul Suster, Abbas Agaimy, Delia Perez Montiel, Kristyna Pivovarcikova, Kvetoslava Michalova, Ondrej Daum, Ondrej Ondic, Pavla Rotterova, Michal Michal, Ondrej Hes. University of British Columbia, Vancouver, Canada; Charles University, University Hospital, Plzen, Czech Republic; University of Calgary, Calgary, Canada; Robert J. Tomsich Pathology Institute, Cleveland Clinic, Cleveland, OH; Bellvitge University Hospital, Barcelona, Spain; Bart s Cancer Center, London, United Kingdom; Hospital Cochin, Paris, France; Medical Colledge Wisconsin, Milwaukee, WI; University of Erlangen, Erlangen, Germany; Institute Nacional de Cancerologia, Mexico City, Mexico. 134 Biphasic Papillary Renal Cell Carcinoma Is a Rare and Distinct Morphologic Variant Clinicopathologic Study of 24 Novel Cases (1065) Kiril Trpkov, Daniel Athanazio, Cristina Magi-Galluzzi, Helene Yilmaz, David Clouston, Abbas Agaimy, Sean R Williamson, Fadi Brimo, Jose I Lopez, Monika Ulamec, Nathalie Rioux-Leclercq, Maysoun Kassem, Nilesh S Gupta, Samir Al Bashir, Arndt Hartmann, Asli Yilmaz, Ondřej Hes. University of Calgary, Calgary, Canada; Cleveland Clinic, Cleveland, OH; Tissupath, Australia; Erlangen University Hospital, Germany; Henry Ford Hospital, Detroit, MI; McGill University, Montreal, Canada; Cruces University Hospital, Spain; Clinical Center, Zagreb, Croatia; CHU Pontchaillou, Rennes, France; Charles University, Pilsen, Czech Republic. 135 MiRNA as Diagnostic Biomarkers for Renal Cell Carcinoma Subtypes by Chromogenic In Situ Hybridization (891) Ashley Di Meo, Rola Saleeb, Samantha Wala, Adriana Krizova, Manal Gibril, Haiyan Zhai, Mereet Hanna, Maria Pasic, Andrew J Evans, Fadi Brimo, George M Yousef. St. Michael s Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; London Health Sciences Center and Western University, London, ON, Canada; BioGenex Laboratories, Fremont, CA; McGill University Health Centre, Montreal, QC, Canada. 202

263 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Pathologic and Clinical Characteristics of Early Onset Renal Cell Carcinoma (878) Tyler Clemmensen, Win Shun Lai, Soroush Rais- Bahrami, Jennifer Gordetsky. University of Alabama at Birmingham, Birmingham, AL. 137 The Incidence and Outcome of t(6;11) Renal Cell Carcinomas (RCC): A Single Institutional Experience (980) Daniel Matson, Holly L Harper, Les J Henderson, Jennifer J Laffin, E Jason Abel, Wei Huang. University of Wisconsin-Madison, Madison, WI; Case Western Reserve University, Cleveland, OH. 138 Immunohistochemical Phenotype Analysis of a Large Series of Sarcomatoid Renal Cell Carcinoma (952) Fumi Kawakami, Kanishka Sircar, Pheroze Tamboli, Jaime Rodriguez-Canales, Christopher G Wood, Jose A Karam. University of Texas MD Anderson Cancer Center, Houston, TX. 139 Acquired Cystic Kidney Disease and/or Kidney Transplantation Associated Genitourinary Tumors: Report of 37 Tumors (862) Athanase Billis, Leandro LL Freitas, Larissa BE Costa, Marcel A Asato, Karina S Araujo, Daniele M Losada, Amanda P Herculiani, Livia LA Azevedo, Gabriel VBS Tabosa, Bruna C Zaidan, Gabriel LP Oliveira, Lucas QA Bastos, Ruana M Rocha. School of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil. 140 Chromosomal Aberration Pattern in Oncocytic Papillary Renal Cell Carcinoma: Analysis of 28 Cases (983) Kvetoslava Michalova, Petr Steiner, Delia Perez Montiel, Maris Sperga, Saul Suster, Reza Alaghehbandan, Kristyna Pivovarcikova, Ondrej Daum, Ondrej Ondic, Pavla Rotterova, Milan Hora, Michal Michal, Ondrej Hes. Charles University, Medical Faculty and University Hospital, Plzen, Czech Republic; Institute Nacional de Cancerologia, Mexico City, Mexico; East University, Riga, Latvia; Medical College, Wisconsin, Milwaukee, WI; Faculty of Medicine, University of British Columbia, Vancouver, Canada. 141 Primary Renal Synovial Sarcomas: Morphological, Immunohistochemical, and Molecular Genetic Findings (1021) Laurel Rose, Liang Cheng, David Grignon, Rong Fan, Shaoxiong Chen. Indiana University, Indianapolis, IN. 142 Metastatic Renal Cell Carcinoma Presenting as a Solitary Subcentimeter Gastroesophageal Mucosal Polyp: Report of 5 Cases (1043) Mohanad Shaar, Cynthia Guy, Shannon McCall, Diana Cardona, Xuefeng Zhang. Duke University Medical Center, Durham, NC. 143 The Incidence and Outcome of Xp11.2 Translocation Renal Cell Carcinomas (RCC): A Single Institutional Experience (979) Daniel Matson, Holly L Harper, Les J Henderson, Jennifer J Laffin, E Jason Abel, Wei Huang. University of Wisconsin-Madison, Madison, WI; Case Western Reserve University, Cleveland, OH. 144 Frequency of Succinate Dehydrogenase and Fumarate Hydratase-Deficient Renal Cell Carcinoma Based on Immunohistochemical Screening with SDHA/SDHB and FH/2SC (967) Tilcia Lopez, Sounak Gupta, Yingbei Chen, Loren P Herrera Hernandez, John C Cheville, Rafael E Jimenez. Hospital Calderón Guardia, San José, Costa Rica; Mayo Clinic, Rochester, MN; Memorial Sloan Kettering Cancer Center, New York, NY. 145 Clear Cell Papillary Renal Cell Carcinoma: A Whole Exome Sequencing Study (924) Sabina Hajiyeva, Weihua Huang, Changhong Yin, Ximing J Yang, John T Fallon, Minghao Zhong. New York Medical College, Valhalla, NY; Northwestern University, Chicago, IL. 146 Anti-TFE3 and Anti-TFEB Antibodies for the Detection of Translocation Renal Cell Carcinomas (trcc) by IHC: A Single Institutional Experience (981) Daniel Matson, Holly L Harper, Les J Henderson, Jennifer J Laffin, E Jason Abel, Wei Huang. University of Wisconsin-Madison, Madison, WI; Case Western Reserve University, Cleveland, OH. 147 Renal Cell Tumors with an Entrapped Papillary Component: Evidence for a Tumor-in-Tumor Collision Phenomenon (1077) Sean R Williamson, Liang Cheng, Ramya Gadde, Matthew J Wasco, Nilesh S Gupta, Merce Jorda, Oleksandr N Kryvenko. Henry Ford Health System, Detroit, MI; Indiana University, Indianapolis, IN; St Joseph Mercy Hospital, Ann Arbor, MI; University of Miami, Miami, FL. 148 Renal Cell Carcinoma (RCC) with Extensive Cystic Necrosis (880) Jennifer A Collins, Jonathan I Epstein. The Johns Hopkins University School of Medicine, Baltimore, MD. 149 Prognostic Biomarkers of Systemic Inflammation in Patients with Metastatic Renal Cell Carcinoma (927) Wayne B Harris, Omer Kucuk, Bradley C Carthon, Theresa W Gillespie, Viraj A Master, Adeboye O Osunkoya. Emory University School of Medicine, Atlanta, GA. 150 Clinical Follow-Up of 37 Cases of Chromophobe Renal Cell Carcinoma with Vascular Invasion (1079) Sara E Wobker, Christopher Przybycin, Jonathan I Epstein. University of North Carolina, Chapel Hill, NC; Cleveland Clinic, Cleveland, OH; Johns Hopkins Medical Institutions, Baltimore, MD. 203

264 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Characteristics of Small Renal Cell Carcinomas ( 4 cm) Upstaged to pt3 on Final Pathology (918) Tiffany Graham, Win Shun Lai, Jessica Zarzour, Soroush Rais-Bahrami, Jennifer Gordetsky. University of Alabama at Birmingham, Birmingham, AL. 152 Genetic Heterogeneity in Clear Cell and Papillary Renal Cell Carcinomas with Sarcomatoid Features (1031) Joseph Sanfrancesco, John N Eble, Mingsheng Wang, Shaobo Zhang, David Grignon, Muhammad Idrees, Erik Kouba, Liang Cheng. Indiana University, Indianapolis, IN. 159 Sinonasal Small Cell Neuroendocrine Carcinoma (SNEC): Clinicopathological Study of 37 Cases (1324) Ashvini Natu, Asawari Patil, Munita Bal, Rajiv Kumar, Shubhada Kane. Tata Memorial Centre, Mumbai, Maharashtra, India. 160 Odontogenic Myxoma: Review of Histopathologic, Immunocytochemical and Ultrastructural Features (1306) Mohammad Haeri, H Wu, C Finch, D Citron, O Roncal, John Hicks. Baylor College of Medicine & Texas Children s Hospital, Houston, TX. 153 PD-L1 Expression in High Grade Locally-Advanced Renal Cell Carcinoma (949) Shivani Kandukuri, Toni K Choueiri, Michelle S Hirsch. Brigham And Women s Hospital, Boston, MA; Dana Farber Cancer Institute, Boston, MA. 154 Different Performances of Three Anti-PAX8 Monoclonal Antibodies (1039) Tomoyo Sasaki, Zhiming Liao, Hui Zhang, Cleo Lee, Julia Ma, Weiwei Cai, Lina Liu, Dennis Wang, Joe Couto, Yifei Zhu. Spring Bioscience, Pleasanton, CA. 155 Identification of Altered Genes and Pathways in Tumor versus Normal Tissue from Renal Cell Carcinoma Gene Expression TCGA Data Sets (1646) Konstantin Volyanskyy, Minghao Zhong, John T Fallon, Nevenka Dimitrova. Intellispace Genomics Philips, Hawthorne, NY; Westchester Medical Center, Valhalla, NY. 156 Correlation Between Programmed Death-1 Expression in Tumor Infiltrating Lymphocytes of Matched Primary and Metastatic Clear Cell Renal Cell Carcinoma (CCRCC) and Primary Non-Metastatic CCRCC: An Analysis of 85 Cases with Emphasis on Potential Pitfalls (1622) Michelle DiMarco, Datta Patil, Rishi R Sekar, Viraj A Master, Adeboye O Osunkoya. Emory University School of Medicine, Atlanta, GA; University of Washington Medical Center, Seattle, WA. 157 Immunoprofiling of Renal Cell Carcinoma with Rhabdoid Features Identifies Potential Targets for Adjuvant Treatment by Antibody Drug Conjugates (1644) Buer Song, John E Tomaszewski, Wilfrido D Mojica. University at Buffalo, Buffalo, NY. HEAD & NECK PATHOLOGY 158 The Value of Hyams Grade in an Endoscopically Treated Cohort of Olfactory Neuroblastoma (1318) Stacey K Mardekian, Carl H Snyderman, Aron Z Pollack, Paul Gardner, Raja R Seethala. University of Pittsburgh Medical Center, PA. 161 Matlab Silhouette Analysis of Worst Pattern of Invasion in Oral Squamous Carcinomas (1341) Minhua Wang, Lei Zhang, John E Tomaszewski, Scott Doyle, Margaret Brandwein. State University of New York, Buffalo, NY. 162 Cancer Gestalt: Fused Cancer and Biomarkers in Three- Dimensions-A Novel Way to Envision Tumor Biology (1345) Lei Zhang, Jing He, Poojaben Dhorajiya, Minhua Wang, Scott Doyle, Margaret Brandwein. SUNY at the University at Buffalo, Buffalo, NY. 163 MiRNA-200c and MiRNA-141 as Epithelial Mesenchymal Transition Regulators and Novel Potential Biomarkers in Eyelid Sebaceous Gland Carcinoma (1335) Seema Sen, Mansi Bhardwaj, Kunzang Chosdol, Anjana Sharma, Neelam Pushker, Mandeep S Bajaj, Sameer Bakhshi, Seema Kashyap. Dr R.P Centre, AIIMS, New Delhi, India; AIIMS, New Delhi, India. 164 Perineural Spread in Lymphomas of the Head and Neck (1332) Ana Ruano, Mihai Merzianu. Roswell Park Cancer Institute, Buffalo, NY. 165 HPV Genotyping in Head and Neck Papillomas(HNP): An Institutional Experience (1317) Abul Ala Syed Rifat Mannan, Dana Gao, Aneta Waluszko, Wenjing Shi, David Y Zhang, Fei Ye. Mt Sinai Hospital, New York, NY. 166 Correlation of PDL-1 with STAT-Protein Expression in p16-positive and -Negative Head and Neck Squamous Cell Carcinomas (1329) Kate Poropatich, Germaine Gaber, Ajit Paintal, Kalliopi P Siziopikou, Sandeep Samant, Bharat Mittal. Northwestern University, Chicago, IL. 167 RNA In Situ Hybridization (ISH) for 18 High Risk Human Papilloma Viruses (HPV) in Squamous Cell Carcinoma (SCC) of the Head and Neck: Comparison with p16 Immunohistochemistry (IHC) (1299) Bradley Drumheller, Cynthia Cohen, Diane Lawson, Momin T Siddiqui. Emory University Hospital, Atlanta, GA. 204

265 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Tumor Metabolism and ROS Determine Efficacy of HNSCC Therapy by Modulating Immune Status (1314) Rosemarie Krupar, Ravi R Pathak, Christian Idel, Sven Perner, Andrew G Sikora. University Hospital of Luebeck and Research Center Borstel, Luebeck, Germany; Baylor College of Medicine, Houston, TX; University Hospital of Luebeck, Luebeck, Germany. 176 Papillary Cystic Variant of Acinic Cell Carcinoma Masquerading as Mammary Analogue Secretory Carcinoma of Salivary Gland (1311) Shubhada Kane, Nikita S Oza, Asawari Patil, Munita Bal, Trupti Pai, Ruta Gupta. Tata Memorial Hospital Parel, Mumbai, Maharashtra, India; Gravan Institute of Medical Research, Sydney, Australia. 169 Epidemiology of Patients Diagnosed with Oral Cavity Squamous Cell Carcinoma in South Florida (1328) Yolanda Payne-jameau, Paula S Espinal, Darcy A Kerr, Stuart J Herna, Tanner D Corse, Ronda Sanders, Carmen Gomez-Fernandez. University of Miami Miller School of Medicine, Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center, Miami, FL. 170 Traditional Grading of Oropharyngeal and Non- Oropharyngeal Squamous Cell Carcinomas in the HPV Era (1323) Kathleen Montgomery, Mitra Mehrad, Krystle Lang Kuhs, James Lewis. Vanderbilt University Medical Center, Nashville, TN. 171 Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): A Single Institutional Review with Emphasis on Tumor Prevalence (1288) Nabil Ashraf, Rongqin Ren, Cora Uram-Tuculescu, Celeste N Powers, Adele O Kraft. Virginia Commonwealth University Health System, Richmond, VA. 172 BRAF V600E Mutations in Infarcted Thyroid Carcinoma (1313) Erik Kouba, Andrew Ford, Charmaine G Brown, Chen Yeh, Hyung-Gyoon Kim, Gene P Siegal, Upender Manne, Isam-Eldin Eltoum. University of Alabama-Birmingham, Birmingham, AL; Circulogene, Inc., Homewood, AL. 173 Clinical and Biological Significance of Common Mutational Genotypes of Thyroid Follicular Neoplasia (1285) Joseph F Annunziata, Anna Banizs, Christina M Narick, Sara Jackson, Jan F Silverman, Sydney Finkelstein. Allegheny General Hospital, Pittsburgh, PA; Interpace Diagnostics, Pittsburgh, PA. 174 Warthin s Tumor of the Parotid Gland: A Simple Lesion with Complex Clinical Implications; a Clinical Pathologic Review (1325) Anam Naumaan, Ritu Ghai, Paolo Gattuso. Rush University Medical Center, Chicago, IL. 175 Warthin s Tumor: A Study of 73 Cases with Emphasis on Association with Other Malignancies (1344) Daniel Zaccarini, Kamal K Khurana. SUNY Upstate Medical University, Syracuse, NY. 177 Plasmacytoid Cells (PLC) in Pleomorphic Salivary Adenomas (PA) and Plasmacytoid Myoepitheliomas (PM) Are Probably Not of Myoepithelial Cell (MC) Origin and May Reflect Cells Capable of Undergoing Epithelial/Mesenchymal Transition (EMT) (1286) Prokopios Argyris, Mark Lingen, Elizabeth A Bilodeau, Ioannis Koutlas. Oral and Maxillofacial Pathology, University of Minnesota, Minneapolis, MN; University of Chicago, Chicago, IL; University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA. 178 SOX10 and GATA3 Expression and Clinical Utility in Adenoid Cystic Carcinoma and Polymorphous Low Grade Adenocarcinoma of the Head and Neck (1303) Ariana B Geromes, Rebecca Chernock, Katherine Kimmelshue, James Lewis, Kim Ely. Vanderbilt University Medical Center, Nashville, TN; Washington University School of Medicine, St. Louis, MO. 179 Salivary Duct Carcinoma and Invasive Ductal Carcinoma of the Breast: A Comparative Immunohistochemical Study (1307) Jalal B Jalaly, Souzan Sanati, Rebecca Chernock, Samir K El-Mofty. Washington University, Saint Louis, MO. 180 HER2 Stain Scoring in Salivary Duct Carcinoma (1309) Ming Jin, David W Cohen, Paul E Wakely. The Ohio State University Wexner Medical Center, Columbus, OH. HEMATOPATHOLOGY 181 Evaluation of Novel Markers for Minimal Residual Disease Testing in B-ALL for Children s Oncology Group Studies (1529) Christopher J Trindade, Zhengwei J Mao, Brent L Wood. National Cancer Institute, Bethesda, MD; University of Washington, Seattle, WA; Seattle Cancer Care Alliance, Seattle, WA. 182 Low-Level BCR-ABL1 Transcripts in B-Lymphoblastic Leukemia/Lymphoma (B-LL) at Diagnosis Are Often Transient, but May Rarely Progress (1347) Nidhi Aggarwal, Raven Brower, Urvashi Surti, Sarah E Gibson. University of Pittsburgh School of Medicine, Pittsburgh, PA. 205

266 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Prognostic Effect of Complex Karyotype, Monosomal Karyotype, and Chromosome 17 Abnormalities in B-Cell Acute Lymphoid Leukemia (1432) Priya Khoral, Eshetu G Atenafu, Kenneth J Craddock, Aaron Schimmer, Hong Chang. University Health Network, Toronto, ON, Canada A Detailed Multiparameter Flow Cytometry Study of 365 Cases of B-Lymphoblastic Leukemia with Subtyping According to the 2016 WHO: A Single Institutional Study (1505) Joshua Segal, Norman Lacayo, Jason Gotlib, Robert Ohgami. Stanford University School of Medicine, Stanford, CA. 185 The Significance of Morphologic Dysplasia in 432 Cases of Acute Lymphoblastic Leukemia and Acute Leukemia of Ambiguous Lineage: Correlation with Cytogenetic, Immunophenotypic, and Molecular Findings (1506) Joshua Segal, Gary Dahl, Norman Lacayo, Jason Gotlib, Robert Ohgami. Stanford University School of Medicine, Stanford, CA. 186 Immunophenotypic Profile of Acute Promyelocytic Leukemia Tested with EuroFlow AML/MDS Antibody Panel (1405) Julia T Geyer, Su Wang-Miller, Giorgio G Inghirami. Weill Cornell Medicine, New York, NY. 187 A Study of Disseminated Intravascular Coagulation in Acute Leukemia Reveals Markedly Elevated D-Dimer Levels Are a Sensitive Indicator of Acute Promyelocytic Leukemia (1471) Jean Oak, Nahid Shahmarvand, Matthew Alcasid, Michael Cascio, Eli Goodman, Bruno Medeiros, Daniel A Arber, James Zehnder, Robert Ohgami. Stanford University, Stanford, CA; Mayo Clinic, Rochester, MN; Oregon Health and Science University, Portland, OR; Virginia Office of the Chief Medical Examiner, Roanoke, VA. 188 Acute Promyelocytic Leukemia-Like Flow Cytometric Phenotype Identifies a Distinct Molecular Subset of NPM1-Mutated Acute Myeloid Leukemia (1456) Emily F Mason, Frank C Kuo, Olga Pozdnyakova. Brigham and Women s Hospital, Harvard Medical School, Boston, MA. 189 Phenotypic Trends within Genomic Classifications of Acute Myeloid Leukemia (1382) Ashley M Cunningham, Mohamed Salama, Jay L Patel, Archana M Agarwal. Univ of Utah School of Medicine, Salt Lake City, UT. 190 De-Novo Acute Myeloid Leukemia (AML). MYC/BCL2/ P53 Protein Expression and Its Infleunce on Over All Survival (OS) in Various Treatment Groups (1449) Mohammad O Mansoor, Fahad Farooq, Haocheng Li, Douglas A Stewart. University of Calgary, Calgary, AB, Canada. 191 The Significance of CD56 Expression and the RAM Immunophenotype, a Recurrent Immunophenotype Seen in Children, in Adult Acute Myeloid Leukemia (1437) Daniel Lazzareschi, Athena Cherry, James Zehnder, Jason Gotlib, Daniel A Arber, Norman Lacayo, Robert Ohgami. Stanford University Medical Center, Palo Alto, CA; Lucile Salter Packard Children s Hospital, Palo Alto, CA. 192 EVI1 Immunohistochemistry Identifies AML Subtypes with Distinct Genetics and Prognosis (1544) Gerald Wertheim, Vinodh Pillai, Rachel Sargent, Michele Paessler, Margaret Lewen, Jie Li, Stephen Master, Martin Carroll, Marlise Luskin. Children s Hosp. of Phila, Phila, PA; Hosp. Univ. of Penn., Phila, PA; Weill Cornell Med College, New York, NY; Boston Children s Hosp, Boston, MA; Dana Farber Cancer Institute, Boston, MA. 193 Characterization of IDH1 p.r132h Mutant Clones Using Mutation Specific Antibody in Myeloid Neoplasms (1434) Habibe Kurt, Carlos E Bueso-Ramos, Joseph Khoury, Mark J Routbort, Rashmi Kanagal-Shamanna, Jeffrey L Jorgensen, Sa Wang, Courtney DiNardo, Luthra Rajyalakshmi, L Jeffrey Medeiros, Keyur P Patel. MD Anderson Cancer Center, Houston, TX. 194 Diagnostic Utility of GATA1 Immunohistochemistry in the Assessment of Myeloid Proliferations Related to Down Syndrome (1439) Winston Lee, Olga K Weinberg, Andrew Evans, Geraldine Pinkus. Brigham and Women s Hospital, Boston, MA; Boston Children s Hospital, Boston, MA; University of Rochester School of Medicine and Dentistry, Rochester, NY. 195 Somatic Mutations in Acute Myeloid Leukemia with Megakaryocytic Differentiation (1531) Christin H Tsao, Jiehao Zhou, Mehdi Nassiri. Indiana University School of Medicine, Indianapolis, IN. 196 Morphologic and Molecular Characteristics of De Novo AML with JAK2V617F Mutation (1417) Juliana Hidalgo, Rashmi Kanagal Shamanna, Mohammad M Mohammad, Zhuang Zuo, L Jeffrey Medeiros, Carlos E Bueso-Ramos. The University of Texas MD Anderson Cancer Center, Houston, TX. 197 JAK2 V617F Mutation in Acute Myeloid Leukemia (AML): Clinical and Pathologic Comparison Between De Novo AML and Secondary AML Transformed from an Underlying Myeloproliferative Neoplasm (1356) Jason Aynardi, Rashmi Manur, Paul Hess, Seble Chekol, Jennifer Morrissette, Daria Babushok, Elizabeth Hexner, Adam Bagg. University of Pennsylvania, Philadelphia, PA. 206

267 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Mutational Signature Correlates with Proliferative Phenotype in NCCN Poor-Risk Acute Myeloid Leukemia (1510) Aaron C Shaver, Ridas Juskevicius, Robert D Daber, Stephen A Strickland, Paul B Ferrell, Michael Byrne, Sanjay R Mohan, Cindy L Vnencak-Jones, Mary M Zutter, Annette S Kim, Adam Seegmiller, Michael R Savona, David R Head. Vanderbilt University, Nashville, TN; BioReference Laboratories, Elmwood Park, NJ; Brigham and Women s Hospital, Boston, MA. 199 Genotypic and Clinical Heterogeneity Amongst NCCN Favorable-Risk Acute Myeloid Leukemias (1504) Adam Seegmiller, Stephen A Strickland, Aaron C Shaver, Robert D Daber, Michael Byrne, P B Ferrell, David R Head, Sanjay R Mohan, Cindy L Vnencak- Jones, Mary M Zutter, Michael R Savona. Vanderbilt University School of Medicine, Nashville, TN; BioReference Laboratories, Elmwood Park, NJ. 200 Clinicopathologic Features of Adult Myeloid Neoplasm with T(16;21) (1441) Huifei Liu, Cameron Yin, Sa Wang, Jie Xu, L Jeffrey Medeiros, Guilin Tang. Houston Methodist Hospital, Houston, TX; University of Texas MD Anderson Cancer Center, Houston, TX. 201 Multiple Concurrent FMS-Like Tyrosine Kinase 3-Internal Tandem Duplications (FLT3-ITDs) Do Not Impact Clinical Outcome in Acute Myeloid Leukemia (AML) Patients (1397) Hong Fang, Matthew T Howard, Dong Chen, Rong He, David S Viswanatha. Mayo Clinic, Rochester, MN. 202 Late-Relapse Acute Myeloid Leukemia Suggests Diverse Clonal Pathways and Apparent Association with Myeloid Sarcoma (1443) Yen-Chun Liu, Urvashi Surti, Raven Brower, Steven H Swerdlow. University of Pittsburgh School of Medicine, Pittsburgh, PA. 203 Persistent Clonal Cytogenetic Abnormalities in Normal Bone Marrow Status Post Chemotherapy for Acute Leukemia Arising from Myelodysplastic Syndrome Results in Imminent, Aggressive Disease Relapse (1447) Catherine Luedke, Rachel Jug, Xin Liu, Catherine Rehder, Chad McCall, Anand S Lagoo, Endi Wang. Duke Health, Durham, NC. 204 Results of Ancillary Studies on Day 14 Bone Marrows Predict Day 28 Status in Acute Myeloid Leukemia (1388) Jonathan J Douds, Allison M Wasserman, Aaron C Shaver. Vanderbilt University, Nashville, TN. 205 Next Generation Sequencing Can Reliably Detect Diagnostic and Novel Fusions in Leukemia (1367) Eduardo Castro-Echeverry, Julia Choi, Linden Morales, Kimberly Walker, Riyam Zreik, Arundhati Rao. Baylor Scott & White Hospital, Temple, TX. 206 Specific Dysplastic Findings Correlate with Gene Mutations in De Novo AML (1542) Olga K Weinberg, Christopher J Gibson, Olga Pozdnyakova, Frank C Kuo, Benjamin Ebert, Robert P Hasserjian. Boston Children s Hospital 2. Brigham and Women s Hospital 3. Massachusetts General Hospital, Boston, MA. 207 Genetic Landscape of Non-R882 DNMT3A Mutations Is Distinct from DNMT3A R882 Mutations (1488) Andres E Quesada, Richard SP Huang, Raja Luthra, Keyur P Patel, Kurt Hodges, Chi Y Ok, Mark J Routbort, Carlos E Bueso-Ramos, L Jeffrey Medeiros, Rashmi Kanagal-Shamanna. M.D. Anderson Cancer Center, Houston, TX; Baylor College of Medicine, Houston, TX. 208 Myeloid Neoplasms with Concurrent BCR-ABL1 and CBFB-MYH11 Rearrangements: Clinicopathologic Features and Treatment Implications (1501) Alireza Salem, Guilin Tang, Sanam Loghavi, Shimin Hu, L Jeffrey Medeiros, Joseph Khoury. The University of Texas, MD Anderson Cancer Center, Houston, TX. 209 Secondary t(9;22)(q34;q11.2)/bcr-abl1 Rearrangement Is a Fatal Event in Myeloid/Lymphoid Neoplasms (1556) Lan Zheng, Xin Han, Zimu Gong, L Jeffrey Medeiros, Shimin Hu. MD Anderson Cancer Center, Houston, TX. 210 Does SF3B1/TET2 Double Mutation Portend Better or Worse Prognosis Than Isolated SF3B1 or Isolated TET2 Mutation? (1517) Jinming Song, Mohammad Hussaini, Rashid Talha, Hailing Zhang, Ling Zhang, Haipeng Shao, Xiaohui Zhang, Lynn Moscinski. H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL. 211 Relationship of p21 Expression and p53 Mutation Status in Acute Myeloid Leukemia and Myelodysplastic Syndrome (1394) Mohammad Eskandari, Swati Goel, Amit Verma, Joseph Albanese, Yanhua Wang. MMC, Bronx, NY. 212 Evaluation of Myeloid Neoplasm with Erythroid Predominance (1372) Yan Chen, Maryam Pourabdollah, Eshetu G Atenafu, Aaron Schimmer, Hong Chang. University Health Network, Toronto, ON, Canada. 207

268 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Pure Erythroid Leukemia in the Era of the Revised 2016 WHO Classification of Acute Myeloid Leukemia: Further Defining the Disease Group and Patient Outcome (1494) Erica F Reinig, Patricia T Greipp, April Chiu, Kaaren K Reichard. Mayo Clinic, Rocheser, MN; Mayo Clinic, Rochester, MN. 214 The Significance of ASXL1/RUNX1 Double Mutations in Myelodysplastic Syndromes: Even Worse Prognosis? (1551) Hailing Zhang, Mohammad Hussaini, Xiaohui Zhang, Haipeng Shao, Lynn Moscinski, Jinming Song. Moffitt Cancer Center, Tampa, FL. 215 Myelodysplastic Syndromes with KMT2A(MLL) Partial Tandem Duplications Demonstrate Unique Clinical, Immunophenotypic, Therapeutic, and Survival Characteristics (1376) Sarah Choi, Rajan Dewar, Lina Shao. University of Michigan, Ann Arbor, MI. 216 Necroptosis Is a Novel Pathogenic Mechanism in Myelodysplastic Syndrome (1476) Vamsi Parimi, Reeba Omman, Jiwang Zhang, Ameet R Kini. Loyola University Medical Center, Maywood, IL. 217 Automated Neutrophil Parameters Are Useful in Assessing Myelodysplastic Syndrome (1462) Ali Nael, Anna Shestakova, Virgilita Nora, Sherif Rezk, Xiaohui Zhao. UCI Med Ctr, Orange, CA; Children s Hospital LA, Loa Angeles, CA. 218 Analysis of Blastic Plasmacytoid Dendritic Cell Neoplasm with Translocations Involving the MYC Locus Identifies t(6;8)(p21;q24) as a Recurrent Cytogenetic Abnormality: A Multi-Institutional Study with Review of the Literature (1365) Eugene Carneal, Karen M Chisholm, Michael Cascio, Jie Yan, Athena Cherry, Charles D Bangs, Chung-Che Chang, Tracy George, Robert Ohgami. Stanford University Medical Center, Stanford, CA; University of New Mexico, Albuquerque, NM; Oregon Health and Science University, Portland, OR; Seattle Children s Hospital, Seattle, WA; Florida Hospital, University of Central Florida, Orlando, FL. 219 PD-L1 Protein and mrna Expression in Blastic Plasmacytoid Dendritic Cell Neoplasm (1355) Phyu P Aung, Reza Nejati, Sanam Loghavi, Zhuang Zuo, Weina Chen, Carlos A Torres-Cabala, Marina Konopleva, Zhenya Tang, L Jeffrey Medeiros, Victor G Prieto, Naveen Pemmaraju, Joseph Khoury. UT-MDACC, Houston, TX; Southwestern, Dallas, TX. 220 Flow Cytometric Immunophenotypic Study of Monocytes and Granulocytes in Myeloid Neoplasms and Reactive Conditions (1364) Laura Brown, Da Zhang, Wei Cui. University of Kansas, Kansas City, KS. INFECTIOUS DISEASE PATHOLOGY 221 Modified Acid Fast Stains and Molecular Diagnostics for Early Diagnosis of Legionella micdadei Infection (1558) Gregory Cheeney, Kurosawa Kyoko, Daniel Hoogestraat, Dhruba SenGupta, Kelly Smith, Andrew Bryan. Univerity of Washington, Seattle, WA. 222 Mycobacteria Immunohistochemistry Is an Effective Screening Tool for Molecular Identification (1577) Isaac Solomon, Melanie E Johncilla, Jason L Hornick, Danny A Milner. Brigham and Women s Hospital, Boston, MA. 223 Jones Methenamine Silver Stain Is a Useful Adjunct Stain in the Histopathologic Diagnosis of Leishmaniasis (1570) Andrew Norgan, Bobbi S Pritt. Mayo Clinic, Rochester, MN. 224 Expression of Platelet-Associated Marker CD42b on Histoplasma (1571) Dennis P O Malley, Liang Cheng, Young S Kim. Clarient/NeoGenomics, Aliso Viejo, CA; Indiana University, Indianapolis, IN; City of Hope, Duarte, CA. 225 Detection of Incidental Helicobacter pylori Infection with High Rates of Clarithromycin Resistance in Bariatric Surgery Specimens (1561) Zeljko Dvanajscak, Juan Rong, John A Thorson, Jason Y Park, Mark A Valasek. University of California San Diego, San Diego, CA; University of Texas Southwestern/Dallas Children s Hospital, Dallas, TX. 226 Acid Fast Bacilli Status on Non Gynecologic Cytology Specimens, a Study from Colombia (1574) Paula A Rodriguez-Urrego, Angie V Garzon, Juliana Cuervo, Jenny Saavedra-Martinez, Luz Andrea Hernandez, Diana Palacios, Ana Margarita Baldion. Fundacion Santa Fe de Bogota, Bogota, Colombia; Universidad de Los Andes, Bogota, Colombia; Pontificia Universidad Javeriana, Bogota, Colombia. 227 Reproducible Histopathology and Culture Recommendations for Subtle P. Acnes Causing Longterm Joint Pain and Stiffness in Post-Arthroplasty Patients (1562) Julie Fanburg-Smith, Mark Abbruzzese, Randall Lewis. National Academic Pathology, McLean, VA; Sibley Memorial Hospital, Washington, DC. 228 Granulomatous Inflammation Diagnosed by Fine Needle Aspirate Biopsy and Ancillary Testing (1569) Dianna Ng, Ronald Balassanian. UCSF Medical Center, San Francisco, CA. 208

269 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Primary Syphilis in the Tonsil: Challenges in Histopathological Diagnosis (1579) Cheng-Han Yang, Ting-Yi Su, Kai-Ping Chang, Li-yu Lee. Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. 230 Immunohistochemical Study of Mucins in Human Intestinal Spirochetosis (1572) Sho Ogata, Ken Shimizu, Susumu Tominaga, Kuniaki Nakanishi. National Defense Medical College Hospital, Tokorozawa, Japan; JCHO Saitama Medical Center, Saitama, Japan; National Defense Medical College, Tokorozawa, Japan. 231 Morphologic Characterization of Incidentally Discovered Granulomas in Lung Neoplasms (1578) Neelima Valluru, Swati Mehrotra, Stefan Pambuccian, Vijayalakshmi Ananthanarayanan. Loyola University Medical Center, Maywood, IL. 232 Acid Fastness of Histoplasma in Surgical Pathology Practice: Can Ziehl Neelsen Stain Be an Additional Histochemical Stain for Fungi? (1566) Deepali Jain, Madhu Rajeshwari, Immaculata Xess, Mehar C Sharma. AII India Institute of Medical Sciences, New Delhi, India. 233 Helicobacter Pylori Clarithromycin Resistance Mutations Are Common and Associated with Increased Treatment Failures: San Diego Helicobacter Pylori Antibiotic Resistance (SD HELP) Study (1559) Brian Cox, Irene Thung, Esha Gollapalle, Vera Vavinskaya, Zeljko Dvanajscak, Isabel Rosendahl, Jason Y Park, Sheila E Crowe, Mark A Valasek. University of California San Diego, San Diego, CA; University of California San Diego, La Jolla, CA; University of Texas Southwestern Medical School/ Dallas Children s Hospital, Dallas, TX. 234 Toxoplasma gondii PruΔKU80 and Its Parental Strain Pru: Modulation of Brain Cyst Formation During Chronic Toxoplasmosis from an Immune Facet (1567) Ibrahim Khalifeh, Martin Karam, Aya Khairallah, Hiba El Hajj. American University of Beirut, Beirut, Lebanon. 235 Genomic and Clinical Characterization of Methicillin- Resistant Staphylococcus aureus (MRSA) in Pediatric Patients from a Suburban New York City Children s Hospital (1565) Sabina Hajiyeva, Henry Lin, Sheila Nolan, Abhay Dhand, Weihua Huang, Jian Zhuge, Aram Hong, Minghao Zhong, Nevenka Dimitravo, John T Fallon, Guiqing Wang. New York Medical College, Valhalla, NY; Philips North America, Cambridge, MA. PANCREAS & BILIARY TREE 236 Combined FISH, IHC and NGS Identifies New Therapeutic Targets in Cholangiocarcinomas (1805) Dominic Patel, Rifat Hamoudi, Saif Khan, Ignacio Puccio, Julien Edeline, John Bridgewater, Manuel Rodriguez-Justo. UCL, Cancer Institute, London, United Kingdom; UCL, Division of Surgery, London, United Kingdom. 237 Isocitrate Dehydrogenase Gene Mutations in Cholangiocarcinoma (1818) Megan Wachsmann, Daniella Pinho, Rosalyn Ram, Suntrea TG Hammer, Dwight Oliver. The University of Texas Southwestern Medical Center, Dallas, TX. 238 Prognostic Significance of Cleaved Caspase-3 in Biliary Tract Carcinomas (1789) Zanobia Khan, Prashant Bavi, David Hedley, Jennifer J Knox, Stefano Serra. University Health Network, University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada. 239 Prognostic Significance of PD-L1 Expression in Extrahepatic Cholangiocarcinoma (1817) Takashi Ueno, Tomoko Mitsuhashi, Yutaka Hatanaka, Takahiro Tsuchikawa, Keisuke Okamura, Yoshihiro Matsuno, Satoshi Hirano. Hokkaido University Hospital, Sapporo, Hokkaido, Japan; Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. 240 TTF-1 and Napsin-A Staining in Pancreatic and Hepatobiliary Adenocarcinomas (1815) Aditya Talwar, Jan F Silverman. Allegheny General Hospital, Pittsburgh, PA. 241 Sequential Analysis of Pancreatic Cystic Lesions Generates a Significantly Higher Diagnostic Accuracy at Molecular Than Cytologic Levels (1811) Ali Sakhdari, Ediz F Cosar, Lloyd Hutchinson. University of Massachusetts Memorial Medical Center, Worcester, MA. 242 Prognostic Values and Clinicopathological Significances of MUC13 and AGR2 Expressions in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas (1796) Kumiko Mito, Michihiro Saito, Kohei Morita, Iruru Maetani, Naohiro Sata, Noriyoshi Fukushima. Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan; Toho University Ohashi Medical Center, Meguro-ku, Tokyo, Japan. 209

270 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Molecular Analysis of Pancreatic Malignant Serous Cystic Tumors by Targeted Next Generation Sequencing (1820) Hongfa Zhu, Huai-Bin Mabel Ko, Alexandros D Polydorides, Noam Harpaz, John T Fallon, Minghao Zhong. Icahn School of Medicine at Mount Sinai, New York, NY; Westchester Medical Center, Valhalla, NY. 244 Significance of T1a and T1b Carcinoma Arising in Mucinous Cystic Neoplasm of Pancreas (1785) Ling Hui, Matthew H Katz, Asif Rashid, Wai Chin Foo, Manonmani Sundar, Jeffrey E Lee, Eric P Tamm, Jason B Fleming, Huamin Wang. Univeristy of Texas MD Anderson Cancer Center, Houston, TX. 245 Diagnostic Feasibility and Accuracy of Endoscopic Ultrasound-Guided Fine Needle Core Biopsy (EUS- FNB): A Single-Center Large Cohort Study (1780) Antonio De Leo, Costantino Ricci, Giovanni Taffurelli, Claudio Ricci, Riccardo Casadei, Nico Pagano, Donatella DS Santini. Pathology Unit, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy; S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy. 246 Evaluating Tumor Budding in Pancreatic Cancer: Simple and Reliable (1788) Eva Karamitopoulou, Martin Wartenberg, Inti Zlobec, Alessandro Lugli. University of Bern, Bern, Switzerland. 247 Prognostic Significance of the of Involved Lymphatic Vessels in Patients with Resectable Pancreatic Head Cancer (1798) Kohei Morita, Kumiko Mito, Hisashi Oshiro, Naohiro Sata, Toshiro Niki, Noriyoshi Fukushima. Jichi Medical University, Shimotsuke, Japan; Jichi Medical University, Shimotsueke, Japan. 248 Validation of a Size-Based T-Staging Protocol for Pancreatic Ductal Adenocarcinoma After Neoadjuvant Chemoradiation Therapy (1816) Katsunori Uchida, Yasuhiro Murata, Masayuki Kishiwada, Shuji Isaji. Mie University Graduate School of Medicine, Tsu, MIE, Japan. 249 Expression of Estrogen Receptor beta Isoforms in Pancreatic Adenocarcinoma (1819) Mamoun Younes, Charles J Ly, Kanchan Singh, Atilla Ertan, Sushovan Guha, Pamela S Younes, Jennifer M Bailey. University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX. 250 Diagnostic Utility of VHL, Maspin, IMP3 and S100P in the Evaluation of Pancreatic Resection Margins from Frozen Tissue (1814) Rachel Swarrow, Haiyan Liu, Fan Lin. Geisinger Medical Center, Danville, PA. 251 Loss of Hes1 Is a Common Finding in Human Pancreatic Ductal Carcinoma and Is Associated with Loss of SMAD4 (1779) Min Cui, Zhenjian Cai, Amad Awadallah, Wei Xin. University Hospitals Cleveland Medical Center, Cleveland, OH; Case Western Reserve University, Cleveland, OH. 252 Altered Vitamin D Receptor Expression in Pancreatic Ductal Adenocarcinoma: Insights into Vitamin D Signaling Pathway in Endocrine and Exocrine Pancreas (1771) Tanupriya Agrawal, Yvelisse Suarez. Tufts Medical Center, Boston, MA. 253 Pancreatic Neuroendocrine Tumors Expressing Proinsulin: A Clinicopathologic Analysis (1776) Romulo Celli, Guoping Cai, Ronald Salem, Laura Tang, Dhanpat Jain. Yale Medical School, New Haven, CT; Memorial Sloan- Kettering Cancer Center, New York, NY. PATHOBIOLOGY Gene Signature for Distinguishing Lung Squamous Cell Carcinoma from Head and Neck Squamous Cell Carcinoma (1843) Farah Khalil, Yin Xiong, Anthony Magliocco, Soner Altiok. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. 255 Expanding Therapeutic Options for Patients with Lung Adenocarcinomas Using Oncomine Comprehensive Panel (1852) Kyung Park, Hung Tran, Xiaojun Feng, Mark A Rubin, Helen Fernandes. Weill Cornell Medicine, New York, NY; Englander Institute for Precision Medicine, New York, NY. 256 Effect of Inactivation of HK1, HK2, and HK3 Genes in Colorectal Cancer and Melanoma Cell Lines (1844) Anna Kudryavtseva, Maria Fedorova, Irina Karpova, Nadezhda Volchenko, Maria Chernichenko, Dmitry Sidorov, Anastasiya Snezhkina, Dmitry Kalinin. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation; National Medical Research Radiological Centre, Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation; A.V. Vishnevsky Surgery Institute of the Russian Ministry of Healthcare, Moscow, Russian Federation. 257 Adequacy of the Oncomine Comprehensive Panel for Identifying Potentially Actionable Mutations in Triple Negative Breast Carcinomas (1823) Jordan E Baum, Pan Zhang, Sandra J Shin, Hung Tran, Xiaojun Feng, Helen Fernandes. Weill Cornell Medicine, New York, NY. 210

271 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Analysis of DNA Methylation in Breast Cancer for Field Effect Using Contralateral Tissue as the Reference (1841) Rahul M Jawale, Chelsey A Mullen, Kelly J Gregory, Eva P Browne, Giovanna M Crisi, Christopher N Otis, Sallie S Schneider, Brian T Pentecost, Kathleen F Arcaro. Baystate Medical Center, Springfield, MA; University of Massachusetts, Amherst, MA; New York State Department of Health, Albany, NY. 259 Luminal Androgen Receptor and Androgen Receptor- High Triple-Negative Breast Cancers Are Genetically Similar to Luminal B Breast Cancers (1854) Ashwini Raghavendra, Kathleen A Burke, Jisun Kim, Felipe Geyer, Samuel H Berman, Charlotte K Ng, Simon Powell, Britta Weigelt, Sarat Chandarlapaty, Jorge Reis- Filho. Memorial Sloan Kettering Cancer Center, New York, NY; University Hospital Basel, Basel, Switzerland. 260 Both MHC I and MHC II Pathways Are Associated with Improved Survival in Triple-Negative Breast Cancer (1840) Jabed Iqbal, Joe Yeong, Bernett Lee, Jeffrey CT Lim, Xin Min Cheng, Puay Hoon Tan. Singapore General Hospital, Singapore, Singapore; A*STAR, Singapore, Singapore. 261 Computer Extracted Features of Nuclear Shape and Architecture Predict Oncotype DX Risk Categories for Early Stage ER+ Breast Cancer (1864) Jon Whitney, Andrew Janowczyk, German Corredor, Hannah Gilmore, Anant Madabhushi. Case Western, Cleveland, OH. 262 Tissue Based Proteomics on Paraffin Embedded Tissue: A Feasible Means of Identifying and Following Biomarkers in Breast Cancer (1865) Richard Wong, Leslie Timpe, Richard Schwab, Farnaz Hasteh, Bruce Macher, Ten-Yang Yen. University of California San Diego, San Diego, CA; UC San Diego, San Diego, CA; San Francisco State University, San Francisco, CA. 263 Patterns of Clonal Evolution in Colorectal Adenocarcinomas Characterized by Whole Exome Sequencing (1861) Efsevia Vakiani, Ronak H Shah, Marc Attiyeh, Jinru Shia, Alvin P Makohon-Moore, Christine Iacobuzio- Donahue, David Solit. Memorial Sloan Kettering Cancer Center, New York, NY. 264 Molecular Mechanisms Underlying Formation of Carotid Body Tumor Aggressive Phenotype (1845) Anna Kudryavtseva, Dmitry Kalinin, Anastasiya Snezhkina, Alexander Golovyuk, Mikhail Zhestkov, Ekaterina Zhevelyuk, Oleg Stepanov, Alexey Dmitriev, Anatoly Pokrovsky, Boris Alekseev, Andrew Zaretsky, George Krasnov. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation; National Medical Research Center of Radiology, Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation; A.V. Vishnevsky Institute of Surgery, Moscow, Russian Federation; Shemyakin- Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russian Federation. 265 Role of Silencer-of-Death- Domain (SODD) in Barrett s Associated Esophageal Adenocarcinoma (1825) Weibiao Cao, Dan Li, Jie Hong. Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI; Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai, China. 266 A Study of Metastatic Low-Grade Clear Cell Renal Cell Carcinoma by Targeted Next-Generation Sequencing (1866) Sina Zomorrodian, Minghao Zhong, David Y Zhang, Jian Zhuge, Taliya Farooq. New York Medical College at Westchester Medical Center, Valhalla, NY; Icahn School of Medicine at Mount Sinai, New York, NY. 267 Genome-Wide Analysis of Copy Alteration in Well-Differentiated Papillary Mesothelioma (1851) Kyung Park, Jin Chen, Robert Taub, Alain C Borczuk. Weill Cornell Medicine, New York, NY; Columbia University Med Ctr, New York, NY. 268 SMAD4 Mutation Hotspot Analysis and Concomitant Key Cancer-Related Gene Mutation Profile in a Large Cohort of Colorectal Adenocarcinoma Using Next Generation Sequencing Approach (1842) Ryan D Jones, David Dittmann, Nike T Beaubier, Juehua Gao, Guang-Yu Yang. Northwestern University, Chicago, IL. 269 Which PTEN Alterations Are Associated with Protein Loss? (1830) Suzanne Crumley, Russell R Broaddus. The University of Texas M.D. Anderson Cancer Center, Houston, TX. 270 Identification of Sarcoma Fusion Genes by Multiplex Detection of Aberrant 3 to 5 Expression Ratios (1847) Adrian Marino-Enriquez, Frank C Kuo, Michele Baltay, George Demetri, Neal I Lindeman, Jonathan Fletcher, Lynette M Sholl. Brigham and Women s Hospital, Boston, MA; Dana Farber Cancer Institute, Boston, MA. 211

272 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall Novel Multiparametric High Resolution Flow Cytometry to Sort Cell-Specific and Size-Specific Extracellular Vesicles (1849) Terry Morgan, Jared Cobb, David Edwards. OHSU, Portland, OR. 272 Assessment of HER2 Amplification Using NGS Comparison with FISH and IHC (1848) Rebecca M Marrero Rolón, Kyung Park, Pan Zhang, Mark A Rubin, Helen Fernandes. Weill Cornell Medicine, New York, NY. 273 MicroRNA Profiling to Identify Racial Disparities in Smoking Related Lung Tumorigenesis (1827) Jinjun Cheng, Chuanhe Yang, Wafi Bibars, Meiyun Fan, Benny Weksler, Lawrence Pfeffer. The University of Tennessee Health Science Center, Memphis, TN. 274 mir-182*, mir-183, and mir-143 Are Deregulated in Endometrial Endometroid Cancers (1846) Yong Li, Raja Luthra, Jianhua Hu, Li Shen, Russell R Broaddus, Erika Resetova, Yun Wu, Constance T Albarracin. University of Texas Health Science Center, Houston, TX; The University of Texas MD Anderson Cancer Center, Houston, TX. 275 The Prognostic Value of Serum Mi-301a Expression in Prostate Cancer (1858) Devin K Sanders, Mohammed A Alghamdi, Youssef Khafateh, Chendil Damodaran, Houda Alatassi. University of Louisville School of Medicine, Louisville, KY. 276 Stem Cell Features and Accumulation of Genetic Alterations Define Anaplastic Thyroid Carcinomas (1833) Salvador Diaz-Cano, Juan Gonzalez, Hiba ElHassan, Alfredo Blanes. King s College Hospital, London, United Kingdom; University of Malaga School of Medicine, Malaga, Spain. 277 Biological Aggressiveness of Thyroid Neoplasia Depends on the Strength of the Genetic Mutation and Associated Cellular Interaction (1822) Anna Banizs, Joseph F Annunziata, Christina M Narick, Sara Jackson, Jan F Silverman, Sydney Finkelstein. Allegheny General Hospital, Pittsburgh, PA; Interpace Diagnostics, Pittsburgh, PA. 278 Stratification of Tumors with POLE Mutations by Mutations in Additional DNA Polymerases (1856) Joanne K Rutgers, Fangjin Huang, Beatrice Knudson. Cedars Sinai Medical Center, Los Angeles, CA. 279 HPV-Induced Changes to the EBV Life Cycle in an EBV/ HPV Co-Infection Model Utilizing Organotypic Raft Culture (1859) Mingxia Shi, Joseph T Guidry, Rona Scott. Louisiana State University Health Science Center, Shreveport, LA. 280 Personalized Preclinical Cancer Models to Guide Precision Medicine (1853) Chantal Pauli, Benjamin D Hopkins, Davide Prandi, Reid Shaw, Andrea Sboner, Verena Sailer, Rachele Rosati, David J Pisapia, Rema A Rao, Juan Miguel Mosquera, Brian Robinson, Olivier Elemento, Himisha Beltran, Francesca Dimichelis, Christopher Kemp, Carla Grandori, Lewis Cantley, Mark A Rubin. Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY; Meyer Cancer Center, Weill Cornell Medicine, New York, NY; Cure First and SEngine Precision Medicine, Seattle, WA. 281 RAC2 Links B-cell Receptor Signaling and Cell Adhesion in Mantle Cell Lymphoma (1862) Weige Wang, Madina Sukhanova, Dong Sheng, Mei Ming, Ailin Guo, Pin Lu, Jia Li, Xiaoqiu Li, Xiaoyan Zhou, Lynn Y Wang. the University of Chicago, Chicago, IL; Fudan University Shanghai Cancer Center, Shanghai, China; Fudan University Shanghai Medical School, Shanghai, China; Shanghai Institute of Materia Medica, Shanghai, China. 282 Immune Check-Point Blockade as a Potential Therapeutic Strategy for Undifferentiated Malignancies (1832) Kelly Devereaux, Gregory Charville, Shuchun Zhao, Athena Cherry, Matt van de Rijn, Yasodha Natkunam. Stanford Health Care, Stanford, CA. 283 Discordant Expression of cmyc and PD-L1 in Various Human Tumors (1829) Jarish Cohen, Sarah Bowman, Gyula Szabo, Sarah E Umetsu, Gregor Krings, Zoltan Laszik. University of California, San Francisco, San Francisco, CA. 284 Detection of Somatic Mutations in Histologically Normal Lung Tissue: Sectioning and Genomic Method (1821) Behnoush Abedi-Ardekani, Patrice H Avogbe, Matthieu Foll, Magali Olivier, Christine Carreira, Ghislaine Scelo, James D McKay. International Agency for Research on Cancer, Lyon, France. 285 Platelet Cloaked Tumour Cells Educate M2 Macrophage Differentiation (1828) Chris Cluxton, Cathy Spillane, Mark Ward, Cara M Martin, Orla Sheils, Frederick Sheedy, Sharon O Toole, John J O Leary. Trinity College Dublin, Dublin, Ireland; The Coombe Women & Infants University Hospital, Dublin, Ireland. 286 Cleaved NH 2 -Terminal Villin Fragment Regulates Intestinal Cell Extrusion in the Villus Tip (1863) Yaohong Wang, Sudeep P George, Seema Khurana. University of Tennessee Health Science Center, Memphis, TN; University of Houston, Houston, TX; Baylor College of Medicine, Houston, TX. 212

273 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall A Digital Pathology Method to Identify All Forms of CTC (1860) Cathy Spillane, Brendan Ffrench, Anthony Cooney, Carmel Ruttle, Anna Bogdanska, Noreen Gleeson, Feras Abu Saadeh, Waseem Kamran, Ciaran O Riain, Ricahrd Flavin, Michael Gallagher, Cara M Martin, Orla Sheils, Sharon O Toole, John J O Leary. Trinity College Dublin, Dublin, Ireland; Coombe Women & Infants University Hospital, Dublin, Ireland; Dublin City University, Dublin, Ireland; St. James s Hospital, Dublin, Ireland. 288 Expression of GRP78 Protein Is Increased in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm (1826) Hannah H Chen, Hui Zhang, Neelima Valluru, Austin McHenry, Stefan Pambuccian, Xianzhong Ding. Loyola University Medical Center, Maywood, IL. 289 Expression of Zinc Transporter ZIP6 (LIV-1) in Colon Carcinoma (1838) Mobashir Hosameddin, Rami Hayajneh, Andre Kajdacsy-Balla, Grace Guzman, Virgilia Macias. University of Illinois at Chicago, Chicago, IL. 290 Use of Core Needle Biopsies for Molecular Characterization of Advanced Pancreatic Ductal Adenocarcinoma (PDAC) The COMPASS Trial (1835) Sandra Fischer, Kyaw Aung, Rob E Denroche, GunHo Jang, Faiyaz Notta, Sangeet Ghai, Julie M Wilson, Anna J Dodd, Sheng-Ben Liang, Dianne Chadwick, Neesha Dhani, David Hedley, Jennifer J Knox, Steven Gallinger. University Health Network, Toronto, ON, Canada; Ontario Cancer Institute for Cancer Research, Toronto, ON, Canada. PEDIATRIC PATHOLOGY 291 Definition of a 3-Protein Signature to Stratify Hepatoblastoma Patients According to Their Prognosis (1875) Marta Garrido, Laura Guerra, Marina Simon, Mikel Azkargorta, Lara Nonell, Manuel Lopez-Santamaria, Maria E Mateos, Cristina Belendez, Diego Plaza, Francisco Hernandez, Marta Mendiola, Isabel Ojanguren, Margaret Childs, Piotr Czauderna, Rudolf Maibach, Bruce Morland, Marie A Buendia, Felix Elortza, Ramon Planas, Maria R Sarrias, Margarita Sala, Carolina Armengol. Hospital Vall d Hebron, Barcelona, Spain; Hospital La Paz, Madrid, Spain; HealthSciences Research Institute Germans Trias i Pujol, Badalona, Spain; CIBEREHD, Barcelona, Spain; CIC biogune-proteored-isciii, Derio, Spain; IMIM, Barcelona, Spain; Hospital Reina Sofía, Cordoba, Spain; Hospital Gregorio Marañón, Madrid, Spain; Hospital Germans Trias i Pujol, Badalona, Spain; Nottingham Clinical Trials Unit, Nottingham, United Kingdom; Medical University of Gdansk, Gdansk, Poland; IBCSG, Berne, Switzerland; Birmingham Children s Hospital, Birmingham, United Kingdom; Centre Hepatobiliaire Paul Brousse, Villejuif, France; IGTP, Badalona, Spain. 292 The Role of Hypoxia-Inducible NPY System in Dissemination of Ewing Sarcoma A Mouse Xenograft Model (1874) Susana Galli, Jason Tilan, Sung-Hyeok Hong, Rachel Acree, Katherine Connors, Meredith Horton, Akanksha Mahajan, Larissa Wietlisbach, Yi-Chien Lee, Olga Rodriguez, Christopher Albanese, Joanna Kitlinska. Georgetown University Medical Center, Washington, DC. 293 Deep Juvenile Xanthogranuloma (DJXG), 41 New Subcutaneous (SQ) and Intramuscular (IM) Cases, Reclassification as a Benign Fibrohistiocytic Tumor Variant (1873) Julie Fanburg-Smith, Michele Anderson, Katja Specht, Aaron Auerbach, Brian Rubin. National Academic Pathology, McLean, VA; AFIP/Joint Pathology Center, Silver Spring, MD; Cleveland Clinic, Cleveland, OH. 294 Characteristics of Intestinal Metaplasia in Stomach Antrum in a Pediatric Population (1885) Geling Li, David R Kelly, Lei Zhao. Children s of Alabama, Birmingham, AL; Univ. of Alabama, Birmingham, AL. 295 Clinical, Microscopic and Molecular Presentation of Pediatric Cutaneous Leishmaniasis (1872) Gabriel Dunya, Ibrahim Khalifeh. American University of Beirut, Beirut, Lebanon. 213

274 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall TLE1 Immunohistochemistry, a Useful Adjunct in the Diagnosis of Clear Cell Sarcoma of the Kidney (1891) Jared T Shows, Ali Nael, Henry Tran, Ramzi Bawab, Steven Swartwood, Shengmei Zhou, Shamlal Mangray, Nick Shillingford. Children s Hospital Los Angeles, Los Angeles, CA; Keck School of Medicine, Los Angeles, CA; Rhode Island Hospital, Providence, RI; Warren Alpert Medical School of Brown University, Providence, RI. 297 Gestational Buprenorphine Therapy and Association with Placental Dysmaturity (1883) Elizabeth Kertowidjojo, Adela Cimic, Cynthia Kaplan. Stony Brook University Hospital, Stony Brook, NY. 305 Familial Acute Myeloid Leukemia/Myelodysplastic Syndrome with Germline RUNX1 Mutations: A Single Instituion Experience (1878) Vivian Hathuc, Kelly Walkovich, Dale Bixby, Lina Shao, Lauren Smith. University of Michigan, Ann Arbor, MI. 306 YY1 Expression in Wilms- Tumor (1868) Lourdes Cabrera-Muñoz, Sara Huerta-Yepez, Luis E Juarez-Villegas, Marta Zapata-Tarres, Stanislaw Sadowinski-Pine. Hospital Infantil de Mexico Federico Gomez, Mexico, Mexico; Hosptal Infantil de Mexico Federico Gomez, Mexico, Mexico. 298 Russell Body Gastritis in Children: Histopathological Analysis and Clinical Significance (1882) Jaswinder Kaur, Hend Abulsayen, Siraj M El Jamal, Ali G Saad. University of Mississippi Medical Center, Jackson, MS. 299 Endoscopic Features and Clinical Symptoms Associated with Pediatric Helicobacter Infection (1888) Nada Naiyer, Christina A Arnold, Michael A Arnold, Miriam R Conces. The Ohio State University Wexner Medical Center, Columbus, OH; Nationwide Children s Hospital, Columbus, OH. 300 Identification of 2 Novel Transcript Fusions Coexisting with EML4-ALK in a New Case of ALK-Positive Pediatric Renal Cell Carcinoma (1871) Larisa Debelenko, Huang Weihua, Jian Zhuge, Changhong Yin, Minghao Zhong, Mehmet Ozkaynak, John T Fallon. New York Medical College, Valhalla, NY. 301 Assessment of PD-L1 Expression in Pediatric High- Grade Gliomas (1893) Mariona Suñol, Iban Aldecoa, Ofelia Cruz, Angel Montero, Eva Rodríguez, Teresa Ribalta. Sant Joan de Déu Barcelona Children s Hospital, Barcelona, Spain. 302 Pulmonary Alveolar Proteinosis Associated with STAT5b Deficiency: A Rare Entity (1879) John Hicks, David Berger. Texas Children, Houston, TX. 303 Histopathologic Correlation with the Newly Defined Term Placenta (1894) Ashley N Vogel, Jordyn B Tumas, Dan de Cotiis, Amanda Roman, Joanna Chan. Thomas Jefferson University, Philadelphia, PA; Einstein Medical Center, Philadelphia, PA. 304 Malignant Ectomesenchymoma(MEM): Series Analysis of a Histologically and Genetically Heterogeneous Tumor (1877) Brannan Griffin, Pauline Chou, David George, Lawrence Jennings, Nicoleta Arva. Northwestern University, Feinberg School of Medicine, Chicago, IL; Lurie Children s Hospital of Chicago, Chicago, IL. 307 Pediatric Malignant Neoplasms Involving Horseshoe Kidneys: An Institutional Experience Including the First Case of Clear Cell Sarcoma of Kidney and the First Reported Case of EGFR Internal Tandem Duplication (1890) Teresa Santiago, Michael R Clay, Elizabeth Azzato, Scott Newman, Israel Fernandez-Pineda, Kim Nichols, Jinghui Zhang, James R Downing, Andrew M Davidoff, Rachel Brennan, David Ellison. St. Jude Children s Research Hospital, Memphis, TN. 308 The Presence of Intervillous Thrombi Is Associated with Abnormalities in the Maternal and Fetal Circulation (1887) Cathleen E Matrai, Rebecca Baergen. NYPH Weill Cornell Medicine, New York, NY. 309 Congenital Leukemia: Clinicopathological Study of 5 Cases (1886) Amanda E Lo, Chuanyi Mark Lu, Rachel Jug, Catherine Luedke, Endi Wang. Duke University Medical Center, Durham, NC; University of California San Francisco, San Francisco, CA. 310 Clinicopathologic Characteristics of Two Cases of Pediatric Histiocytic Neoplasms Following T-ALL with Identical Molecular Signature as Their Respective Original Malignant Clone (1892) Catherine I Socec, Dehua Wang, Richard McMasters. Cincinnati Children s Hospital Medical Center, Cincinnati, OH. 311 Lobular Capillary Hemangioma of the Middle Ear in Children: Clinical, Pathological and Molecular Characteristics of Three Cases of This Exceedingly Rare Entity (1889) Tejal Patel, Steven Andreoli, Siraj M El Jamal, Ali G Saad. University of Mississippi Medical Center, Jackson, MS; Wolfson Children s Hospital, Jacksonville, FL. 312 PD-L1 Expression in Villitis of Unknown Etiology (1876) Daniel L Geisler, Lisa Friedman, Margaret Moore, Anne Mills, Robin LeGallo. University of Virginia, Charlottesville, VA. 214

275 ABSTRACTS POSTER SESSION POSTER SESSION IV Tuesday, March Day, Date, 07, :00 0:00 PM AM - 4:30-0:00 PM PM Exhibit Hall 1 BREAST PATHOLOGY 1 Trop-2 Overexpression in the Axillary Lmph Nodes of Patients with Lobular Carcinoma Identifies Candidates for Adjuvant Treatment with the Antibody Drug Conjugate IMMU-132 (263) Shabnam Samankan, Elizabeth M Korangy, Wilfrido Mojica. University at Buffalo, Buffalo, NY. 2 Correlation Between the Expression of CEACAM6 and Clinicopathological Variables in Breast Cancer (205) Ho-chang Lee, Seung-Myoung Son, Hyung Geun Song, Ok-Jun Lee. Chungbuk National University, Cheongju, Chungcheongbuk-do, Republic of Korea. 3 mrna Expression Analysis of Inhibitors of DNA Binding Proteins: Correlation with Epithelial- Mesenchymal Transition and Cancer Stem Cell Markers in Breast Carcinoma (159) Araceli Garcia-Martinez, Marta Garcia-Escolano, Fernando Ortiz-Martinez, Elena Sanmartin, F I Aranda, Estela Costa, Silvia Delgado, Tina Martin, Gloria Peiro. University General Hospital, Alicante, Spain. 4 The Inhibitor of DNA Binding Proteins: mrna Expression Analysis and Prognostic Relevance in Breast Carcinoma (158) Marta Garcia-Escolano, Araceli Garcia-Martinez, Fernando Ortiz-Martinez, Elena Sanmartin, Francisco J Illan, Jose J Ponce, Hortensia Ballester, Gloria Peiro. University General Hospital, Alicante, Spain. 5 PITX2 Expression Is Elevated in a Progressive Manner in Breast Papilloma and Triple-Negative Breast Carcinoma (102) Di(Andy) Ai, Deborah Jebakumar, Clare McCormick- Baw, Shuang Zhou, Jeryl Baker, Erxi Wu, Lina Liu, Arundhati Rao. Scott & White Memorial Hospital, Temple, TX. 6 Differentially Expressed mirna in the Progression of Infiltrating Ductal Breast Carcinoma (154) Pedro Fernandez, Lourdes Sanchez-Cid, Timothy Thomson. Hospital Clinic and University of Barcelona, Barcelona, Spain; IDIBAPS, Barcelona, Spain; CSIC, Cell Biology, Barcelona, Spain; CIBER-BBN, Barcelona, Spain. 7 Amyloid Precursor Protein as a Potential Marker of Malignancy and Prognosis of ER Negative Breast Cancer (236) Yunbi Ni, Michelle Lee, Julia YS Tsang, Kowk Fai Lau, Gary M Tse. The Chinese University of Hong Kong, Hong Kong, Hong Kong. 8 H3K27me3 Expression and X Chromosome Inactivation in Breast Carcinoma (116) Gregory Bean, Melike Pekmezci, Yunn-Yi Chen, E Shelley Hwang, Gregor Krings. UCSF, San Francisco, CA; Duke, Durham, NC. 9 Overexpression of GATA4 Associates with Aggressive Phenotypes of Triple-Negative Breast Cancer (255) Abdul Rehman, Hyunsung Kim, Yumin Chung, Youngchan Wi, Yeseul Kim, Su-Jin Shin, Seung S Paik, Kiseok Jang. Hanyang University, Seoul, Republic of Korea. 10 FOXA2 Protein Expression Is Associated with Recurrence in Patients with Triple-Negative Breast Cancer (254) Abdul Rehman, Hyunsung Kim, Yumin Chung, Youngchan Wi, Yeseul Kim, Su-Jin Shin, Seung S Paik, Kiseok Jang. Hanyang University, Seoul, Republic of Korea. 11 Characterization of GATA3 Expression in Invasive Breast Cancer-Differences in Histological Subtypes and Immunohistochemically Defined Molecular Subtypes (279) Shaoxian Tang, Baohua Yu, Xiaoli Xu, Yufan Cheng, Rui Bi, Xiangjie Sun, Ruohong Shui, Wentao Yang. Fudan University Shanghai Cancer Center, Shanghai, China. 12 Expression of GHRH-R, a Targetable Biopredictor, in Histologic Subtypes of Triple-Negative Breast Cancer (194) Mahsa Khanlari, Andrew V Schally, Norman L Block, Mehrdad Nadji. University of Miami Miller School of Medicine, Miami, FL; Veterans Affairs Medical Center, Miami, FL. 13 RespondR Signature Identifies Triple-Negative Breast Cancer Patients Who Are Likely to Be Insensitive to Taxane Treatment (109) Sunil Badve, Yesim Gokmen-Polar, Steven A Buechler. Indiana University, Indianapolis, IN; Notre Dame, South Bend, IN. 14 Ubc9 Expression in Correlation with BRCA1 in Hormone Positive (HP) and Triple Negative Breast Cancers (252) Kimberly Point du Jour, AOJ Agboola, Andrew Green, Yuan Liu, Ian Ellis, Veena N Rao, Gabriela Oprea-Ilies. Emory University, Atlanta, GA; Nottingham University, Nottingham, United Kingdom; Morehouse School of Medicine, Atlanta, GA. 15 Triple Negative Breast Cancer Has Worse Overall Survival and Cause-Specific Survival Than Non-Triple Negative Breast Cancer (208) Xiaoxian Li, Jing Yang, Limin Peng, Aysegul A Sahin, Lei Huo, Kevin C Ward, Ruth O Regan, Mylin A Torres, Jane L Meisel. Emory University, Atlanta, GA; The University of Texas MD Anderson Cancer Center, Houston, TX; University of Wisconsin, Madison, WI. 215

276 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall 1 16 Basaloid Salivary Gland-Like Carcinomas of the Breast (BSGLC). Histopathology and Prognosis (223) Vicente Marco, Felip Garcia, Isabel T Rubio, Teresa Soler, Laura Ferrazza, Ignasi Roig, Inmaculada Mendez, Xavier Andreu. Hospital Quironsalud Barcelona, Barcelona, Spain; Hospital Universitari Bellvitge/ICO/IDIBELL, Hospitalet de Llobregat, Spain; Consorci Sanitari de Terrassa, Terrassa, Spain; Hospital General de Granollers, Granollers, Spain; Hospital Parc Tauli, Sabadell, Spain. 17 High VANGL2 Expression Is Associated with Basal-Like Phenotype in Axillary Node-Negative Breast Cancer (155) Catherine Forse, Dushanthi Pinnaduwage, Anna Marie Mulligan, Shelley B Bull, Gordana Kuruzar, Benjamin Pakuts, Helen McNeill, Irene Andrulis. Univ. of Toronto, Toronto, ON, Canada; Sinai Health System, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada; Mount Sinai Hospital, Toronto, ON, Canada. 18 The Differently Expressed Genes Between Low ER Breast Cancer and Triple Negative Breast Cancer: Perspective from a Mixed Asian Ethnicity Cohort in Singapore (304) Joe Yeong, Bernett Lee, Jin Liu, Jeffrey CT Lim, Puay Hoon Tan, Jabed Iqbal. Singapore General Hospital, Singapore, Singapore; Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore. 19 Does Pseudoangiomatous Stromal Hyperplasia (PASH) Exhibit Loss of 13q14? (273) Daniel C Skipper, Jessica A Forcucci, Cynthia A Schandl, Daynna J Wolff, Jonathan S Ralston. Medical University of South Carolina, Charleston, SC. 20 Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy (201) Maria G Kuba, Susan C Lester, Jane Brock. Brigham and Women s Hospital, Boston, MA. 21 Granulomatous Mastitis: A Two-Institution Ten-Year Retrospective Review (110) Gabrielle Baker. Beth Israel Deaconess Medical Center, Boston, MA. 22 Clinicopathologic and Immunophenotypic Characterization of Angiomatosis of the Breast: A Rare Vascular Entity Mistaken for Low-Grade Angiosarcoma (226) Patrick J McIntire, Paula Ginter, Sandra J Shin. Weill Cornell Medicine, New York, NY. 23 Concordance of Automated Image Analysis for Human Epidermal Growth Factor Receptor2 (HER2) Fluorescent In-Situ Hybridization (FISH) with the Current Gold Standards in Clinical Practice (245) Nikoo Parvinnejad, Sonal Varma. Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada. 24 Pilot Study to Assess the Utility of Testing for Circulating HER2/Neu in the Serum of Breast Cancer Patients (231) Sarah AL Morgan, Arun Seth, Yutaka Amemiya, Carlos Parra-Herran, Elzbieta Slodkowska, Fang-I Lu, Sharon Nofech-Mozes, Maureen Trudeau, Wedad Hanna. Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada. 25 EZH2 Overexpression in Breast Cancer: Strong Correlation with HER2 Overexpression (125) Weiwei Chen, Amy Hong Zhang, Fei Yang, Qingqing Ding, Roland Bassett, Barbara Mino, Jaime Rodriguez Canales, Ignacio I Wistuba, Aysegul A Sahin. MD Anderson Cancer Center, Houston, TX. 26 Breast Cancers with HER2 and CEP17 Co- Amplification by FISH: Pathologic Features and Clinical Outcomes (112) Morgan Ballard, Megan Troxell, Kristin Jensen, Kimberly H Allison. Stanford University Medical Center, Stanford, CA; Palo Alto VA Healthcare, Palo Alto, CA. 27 Expression of Interleukin-13 Receptor Alpha 1 Correlates with HER2 Status and Survival of Patients with Invasive Breast Cancer (204) Hee Jung Kwon, Byung-Heon Lee, Young Kyung Bae. Yeungnam University College of Medicine, Daegu, Republic of Korea; School of Medicine, Kyungpook National University, Daegu, Republic of Korea. 28 Breast Cancers with < 4 HER2 Signals/cell and Amplified HER2:CEP17 Ratios by FISH: Pathologic Features and Clinical Outcomes of Cases with CEP17 Monosomy (111) Morgan Ballard, Megan Troxell, Kristin Jensen, Kimberly H Allison. Stanford Hopsital, Stanford, CA; Palo Alto VA Healthcare, Palo Alto, CA. 29 Application of the 2013 HER2 FISH ASCO/CAP Guidelines: A New Hope for Breast Cancer Patients in the Philippines (276) Michael John C Talamayan, Manuelito A Madrid, Raymundo W Lo. St. Luke s Medical Center, Quezon City, Philippines. 30 Novel Fluorescent Co-Localization of Myoepithelium in Breast Tissues Evaluated for HER2 by FISH (303) Hadi Yaziji, Robert Poppiti, Siba El Hussein, Cindy Vargas, Dianelis Gonzalez, Lucia Amador, Carlos Genty. Vitro Molecular Laboratories, Miami, FL; Mt. Sinai Medical Center, Miami Beach, FL. 31 Calidoscope: A Three-Dimensional Tool for Quality Control in Breast Cancer Pathology (183) Mar Iglesias, Belén Pérez-Míes, Federico Rojo, Teresa Hernández-Iglesias, Antonio Martínez. Hospital del Mar, Barcelona, Spain; Hospital Ramón y Cajal, Madrid, Spain; Fundación Jiménez Díaz, Madrid, Spain; Quality Control Program, Madrid, Spain; Hospital Clínic de Barcelona, Barcelona, Spain. 216

277 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall 1 CYTOPATHOLOGY 32 Cytologic Processing of Microbiopsies Is Associated with Higher Sensitivity for Detection of Urothelial Carcinoma Compared to Surgical Processing (451) Todd B Sheridan, Jennifer Yates, Christopher L Owens, Bruce A Woda, Andrew Fischer. University of Massachusetts Medical School, Worcester, MA. 33 Maximum N/C Ratio in the Atypical Urothelial Cells Category Correlates with Follow-Up Malignant Results in Liquid-Based Voided Urine Specimens (375) Jen-Fan Hang, Vivek Charu, Mingjuan L Zhang, Christopher VandenBussche. The Johns Hopkins University School of Medicine, Baltimore, MD; Massachusetts General Hospital, Boston, MA. 34 Performance of Atypical Urothelial Cells (AUC) Group of the Paris System: Experience of a Single Institution (475) Aram Vosoughi, Atousa Ordobazari, John Ekladous, Carmen Gomez, Monica Garcia-Buitrago, Oleksandr N Kryvenko, Merce Jorda. University of Miami / Jackson Memorial Hospital, Miami, FL. 35 Urovysion FISH Test, It Is Not for Fishing (332) Schuharazad Abro, Stefan Pambuccian, Guliz Barkan. Loyola University Medical Center, Maywood, IL. 36 The Diagnostic Concordance Among Cytopathologists Interpreting Urine Cytology Using Paris System Improves with Experience (333) Schuharazad Abro, Ozlem Fidan-Ozbilgin, Stefan Pambuccian, Guliz Barkan, Eva M Wojcik. Loyola Medical Center, Maywood, IL. 37 Stone-Related Atypia in Urinary Tract Cytology Revisited (444) Samah Saharti, Guliz Barkan, Eva M Wojcik, Stefan Pambuccian. Loyola University Health System, Maywood, IL. 38 Are There Cytomorphological Alterations in Exfoliated Urothelial Cells Induced by Systemic Gemcitabine- Cisplatin (GC) Treatment? (443) Samah Saharti, Kimberly R Kruczek, Lu Wang, Eva M Wojcik, Elizabeth Henry, Stefan Pambuccian, Guliz Barkan. Loyola University Health System, Maywood, IL. 39 Squamous Cells with Atypia/HPV Changes in Urine Cytology: Cytology-Histology Correlation (420) Elizabeth Morency, John Sir Philip, Samah Saharti, Ayse I Kilic, Guliz Barkan, Ritu Nayar. Northwestern Memorial Hospital, Chicago, IL; Loyola University Medical Center, Chicago, IL. 40 The Paris System of Urinary Cytopathology Outperforms Unclassfied Diagnostic Nomenclature and Correlates with the Surgical Pathologic Biopsy Diagnosis of the Lower Urinary Tract (341) Elizabeth C Bertsch, Momin T Siddiqui, Carla Ellis. Emory University, Atlanta, GA. 41 Negative UroVysion FISH Cases with Sub-Threshold Chromosomal Abnormalities Carry a Higher Risk of Developing High-Grade Urothelial Carcinoma Compared to True Negatives (437) Matthew Root, Sandhya Dasaraju, Jimmie Stewart, Badrinath Konety, Paari Murugan, Khalid Amin. University of Minnesota Medical Center, Minneapolis, MN. 42 A Comparative Study on the Diagnostic Value of Next Generation Sequencing in Urine Cytology and Bladder Tumor Specimens (461) Tong Sun, Lloyd Hutchinson, Keith Tomaszewicz, Kathleen McCauley, Mandi-Lee Caporelli, Ediz F Cosar, Kristine Cornejo. University of Massachusetts Medical School, Worcester, MA. 43 Implementation of the Paris System for Reporting Urinary Cytology: A Single Institution s Experience (468) Vanda Torous, Dawn Brancely, Paul VanderLaan. Beth Israel Deaconess Medical Center, Boston, MA. 44 The Association of Positive and Suspicious Urinary Cytology with Subsequent Histological Diagnoses (335) Jeffrey Ahlstedt, Laleh Hakima, Samer N Khader. Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY. 45 Urine Cytology in Patients with Interstitial Cystitis/ Bladder Pain Syndrome Classified According to the Paris System for Reporting Urinary Cytology (347) Carla Caruso, Erik R Washburn, Catherine S Abendroth. Penn State Health Hershey Medical Center, Hershey, PA. 46 A Comparative Analysis of the Paris System and Institutional Reporting System for Urine Cytology in Upper Tract Urothelial Specimens (381) Kim HooKim, James Casey, Rossitza Draganova- Tacheva, Marluce Bibbo, Charlambos Solomides. Thomas Jeffferson University, Philadelphia, PA. 47 Utility of Cell Block Preparation in Urine Cytology (356) Kossivi Dantey, Jackie Cuda, Rick Nestler, Sara E Monaco, Juan Xing, Liron Pantanowitz. University of Pittsburgh Medical Center- Shadyside Hospital, Pittsburgh, PA; University of Pittsburgh Medical Center, Pittsburgh, PA. 48 A Paris System-Like Approach and Cell Block Utilization in Urine Cytology (348) Emily Chan, Z Laura Tabatabai, Poonam Vohra. UCSF, San Francisco, CA. 217

278 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall 1 49 Telecytology and Hands-Free Digital Voice Communication for High Volume Rapid On-Site Evaluation: An Workflow Optimization (404) Oscar Lin, Dorota Rudomina, Rusmir Feratovic, Joe Sirintrapun. Memorial Sloan Kettering Cancer Center, New York, NY. 50 Efficacy of Immediate Assessment (IA) Telepathology for Ultrasound-Guided Fine Needle Aspirations (US- FNAs) at a Remote Facility (366) Jessica M Farrell, Gregg A Staerkel, Michael W Riben, Olivia Saavedra, Nancy P Caraway. MD Anderson, Houston, TX. 51 Efficacy of Endoscopic-Guided Fine Needle Aspiration in the Diagnosis of Gastrointestinal Spindle Cell Tumors (418) Ioana Moisini, Khalid Amin, Jimmie Stewart, Tetyana N Mettler. University of Minnesota, Minneapolis, MN. 52 Utility of a PLAG1, LEF1 and MYB Immunostain Panel in the Diagnosis of Basaloid Salivary Gland Neoplasms on Fine Needle Aspiration (479) Lucas Wieck, Momin T Siddiqui, Cynthia Cohen, Alessandra Schmitt, Christopher C Griffith. Emory University, Atlanta, GA. 53 GATA3 Can Be Positive in Serous Carcinoma of Fluid Specimen (Pitfalls of Immunohistochemical Stain Markers Analysis) (434) Shuyue Ren, William Klump. Cooper University Hospital, Camden, NJ. 54 Sox10 Expression of Metastatic Breast Carcinoma in Pleural Fluid Cytology (476) Christopher Vytlacil, Shweta Patel, Jan F Silverman. Allegheny General Hospital, Pittsburgh, PA. 55 Utilization of Transthoracic Ultrasound Guided Fine Needle Aspiration in the Diagnosis and Molecular Profiling of Lung Masses (426) Lais Osmani, Mark Hopkins, Zahra Maleki. The Johns Hopkins Hospital, Baltimore, MD. 56 Utility and Reliability of Cell Block Sections in Predicting HPV Status on Metastatic HNSCC to Neck Nodes (393) Laila Khazai, Jasreman Dhillon. Moffitt Cancer Center, Tampa, FL. 57 Combined Fine Needle Aspiration Cytology and Flow Cytometric Immunophenotyping Is an Effective Method for Diagnosis of Hematolymphoid Disease (396) Hubert Lau, Sharon Wu, Steven Long, Dita Gratzinger. Stanford University, Stanford, CA. 58 Cytologic Diagnosis of Lymphoma and Leukemia in Effusion Fluids: A Series of 88 Cases (373) Fatima T Hamadeh, Aman Ramella, Olaronke Oshilaja, Jordan P Reynolds. Cleveland Clinic, Cleveland, OH; St. Vincent Medical Center, Cleveland, OH. 59 Abstract Withdrawn 60 PELP1 Immunostaining in Metastatic Breast Carcinoma in Fine Needle Aspiration and Effusion Specimens: A Comparison with GATA3 Antibody Staining (376) Lakshmi Harinath, Shweta Patel, Edward Lynch, William Thompson, Jan F Silverman. Allegheny General Hospital, Pittsburgh, PA. 61 Oncocytic Features in Salivary Duct Carcinoma, a Potential Pitfall for Misdiagnosis as Warthin Tumor in Fine Needle Aspiration Samples: Cytomorphologic Analysis of Nine Cases (484) Amy J Zhang, Tetyana N Mettler, Jimmie Stewart, Khalid Amin. University of Minnesota, Minneapolis, MN. 62 Comparison of Different Prostate Immunohistochemistry Markers in the Cytological Diagnosis of Metastatic Prostatic Adenocarcinoma (385) Liwei Jia, Yuying Jiang, Amad Awadallah, Claire W Michael. University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH. 63 Percutaneous Image-Guided Biopsy of the Renal Masses: A Single Institution Study with Comparison of Fine Needle Aspiration and Core Biopsy (480) Howard Wu, Chi-Shun Yang, Muhammad Idrees, Shaoxiong Chen. Indiana University School of Medicine, Indianapolis, IN; Taichung Veterans General Hospital, Taichung, Taiwan. 64 Expression of NKX3.1, Prostatic Specific Antigen and Androgen Receptor in Cytological Specimens Submitted for Metastatic Prostatic Carcinoma Workup (345) Guoping Cai, Rita Abi Raad, Adebowale Adeniran. Yale University School of Medicine, New Haven, CT. 65 The Use of a Tissue-Saving Multiplex Antibody (ADH5) with TTF-1 to Subtype Non-Small Cell Lung Cancer on Cytology Specimens (453) Jordan Sim, Shahid Islam. The Ottawa Hospital, Ottawa, ON, Canada. 66 FNA Diagnosis of Deep-Seated Lymphoma: An Institutional Experience (386) Ming Jin, Paul E Wakely. The Ohio State University Wexner Medical Center, Columubs, OH. 67 Endobronchial Ultrasound Guided Fine Needle Aspiration (EBUS-FNA): A Cytologic Histologic Correlation with Emphasis on Discrepant Cases (394) Peter J Kobalka, Yaxia Zhang, Jennifer A Brainard. The Cleveland Clinic, Cleveland, OH. 68 Impact of Biopsy on Management of Renal Lesions (383) Xiao Huang, Xiaoqi Lin. Northwestern University, Chicago, IL. 218

279 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall 1 GASTROINTESTINAL PATHOLOGY 69 Cell Adhesion Molecule TMIGD1 Is Downregulated in Advanced Colorectal Adenocarcinoma (832) Nicholas Woolf, Rosana D Meyer, Philip A Bondzie, Huihong Xu, Nader Rahimi. Boston University School of Medicine, Boston, MA. 70 Myosin 1e Expression Is Associated with Disease Progression in Colorectal Cancer (644) Filippo Borri, Kodie Stem, Alessandro Bombonati, David Zuzga. Einstein Medical Center, Philadelphia, PA; La Salle University, Philadelphia, PA. 71 Downregulation of Friend Leukemia Integration-1 (FLI1) Characterizes the Stepwise Progression from Normal Stomach Glands to Gastric Adenocarcinomas (675) Armando Del Portillo, Aqiba Bokhari, Anne Koehne de Gonzalez, Elena V Komissarova, Helen E Remotti, Jorge Sepulveda, Antonia Sepulveda. Columbia University, New York, NY. 72 Brushing Cytology with Adjunctive FISH and Biomarker Analyses Is Highly Sensitive and Specific in the Early Detection of Low-Grade Dysplasia in Barrett s Esophagus (678) Yimin Dong, Jing Zhai, Daniel Megna, Ashish Prasad, Sam Moussa, David Baunoch, Anil Prasad. College of Medicine, University of Arizona, Tucson, AZ; Northwest Medical Center, Tucson, AZ; College of Public Health, University of Arizona, Tucson, AZ; Endo Associates of Staten Island, Staten Island, NY; Foothill High School, Tucson, AZ; Adobe Gastroenterology, PLLC., Tucson, AZ; Pathnostics, Inc., Irvine, CA. 73 Characterization of Dysplasia in Non-Targeted Colorectal Biopsies in IBD (736) Yihong R Ma, Huai-Bin Mabel Ko, Hannah J Sfreddo, Alexandros D Polydorides, Hongfa Zhu, Noam Harpaz. Icahn School of Medicine at Mount Sinai, New York, NY; Washington University, St. Louis, MO. 74 Inflammatory Polyposis in Patients with Inflammatory Bowel Disease (737) Yihong R Ma, Huai-Bin Mabel Ko, Hongfa Zhu, Noam Harpaz, Alexandros D Polydorides. Icahn School of Medicine at Mount Sinai, New York, NY. 75 Difference of Histological Alteration Between Preoperative Chemoradiotherapy and Chemotherapy, and It s Clinical Implication (797) Naoki Sakuyama, Motohiro Kojima, Shingo Kawano, Norio Saito, Masaaki Ito, Atsushi Ochiai. National Cancer Center Hospital East, Kashiwa, Chiba, Japan. 76 Characterization of Intestinal Pathology in Adults with Cystic Fibrosis (727) Leo Lin, Grace Y Lin, Paul Quinton, Douglas Conrad, Mojgan Hosseini. UCSD, La Jolla, CA. 77 Indoleamine 2,3-Dioxygenase 1 (IDO1) Expression in Biliary Tract Cancers (638) Prashant Bavi, David Hedley, Jennifer J Knox, Stefano Serra. University Health Network, University of Toronto, Toronto, ON, Canada; Clinical Oncology, University Health Network, University of Toronto, Toronto, ON, Canada. 78 Spectrum of Histopathological Changes Induced by PD-1/PD-L1 Blockade in GI Biopsies: A Preliminary Study (639) Prashant Bavi, Stefano Serra, Marcus Butler, Runjan Chetty. University Health Network, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. 79 YAP1 Is Commonly Overexpressed in FAP-Related Neoplasia (717) Amanda M Kraus, Evelyn Carolina Polanco, Christopher Hartley, Catherine Hagen. Medical College of Wisconsin, Milwaukee, WI. 80 Gastritis and Intestinal Metaplasia in Vertical Sleeve Gastrectomy: A Cause for Systematic Preoperative Screening and Followup in Bariatric Surgery Patients (703) Shriram Jakate, Mark Pool. Rush University Medical Center, Chicago, IL. 81 Chromosome 17 Copy Instability Is Associated with Favorable Prognosis in Non-Surgically Treated Gastroesophageal Adenocarinoma but May Impair Response to Trastuzumab (642) Jacqueline Birkness, Neal Spada, Sanja Dacic, James D Luketich, Katie S Nason, Weijing Sun, Jon Davison. Johns Hopkins University, Baltimore, MD; University of Pittsburgh, Pittsburgh, PA. 82 Co-p53/Ki-67 Immunostaining and NGS Molecular Analysis as an Efficient Approach to Detect Mutant p53 and IBD-Associated Dysplasia (674) Audrey Deeken-Draisey, Haonan Li, Xiaoming You, Nike T Beaubier, Sambasiva Rao, Jie Liao, Guang-Yu Yang. Northwestern, Chicago, IL. 83 Colonic Carcinomas with Sporadic Loss of Mismatch Repair Proteins Are Associated with Loss of HLA Class I (631) Kshitij S Arora, Theodoros Michelakos, Lei Cai, David T Ting, Cristina Ferrone, Soldano Ferrone, Vikram Deshpande. Massachusetts General Hospital, Boston, MA. 84 SMAD4 Immunohistochemical Expression Loss in Esophageal Adenocarcinoma (825) Kevin Waters, Ogechukwu Pearl Eze, Maryam Pezhouh, Yaman Tarabishy, Lysandra Voltaggio, Elizabeth A Montgomery. Johns Hopkins Hospital, Baltimore, MD. 219

280 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall 1 85 Loss of Switch/sucrose Nonfermenting Complex Protein Expression in Undifferentiated Gastrointestinal and Pancreatic Carcinomas (814) Basile Tessier-Cloutier, David Schaeffer, Julinor Bacani, Martin Koebel, Cheng-Han Lee. University of British Columbia, Vancouver, BC, Canada; University of Alberta, Edmonton, AB, Canada; University of Calgary, Calgary, AB, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada. 93 Loss of Expression of CDX2 Is Not a Useful Method for Detecting Epigenetic Gene Alterations (757) Eva Musulen, Anna Martinez-Cardus, Sebastian Moran, Aurelio Ariza, Miquel Angel Carrasco, Manel Esteller. Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain; Hospital Universitari General de Catalunya, Sant Cugat del Valles, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L Hospitalet del Llobregat, Barcelona, Spain. 86 Taiwan Hospital-Based Detection of Microsatellite Instabilities and BRAF Mutation in Colorectal Cancer by Immunohistochemical Method (824) Yu-Chen Wang, Wen-Yih Liang, Anna Fen-Yau Li. Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University, Taipei, Taiwan. 87 Perianal Paget s Disease: Experience of a Single Institution (823) Yu-Chen Wang, Wen-Yih Liang, Anna Fen-Yau Li. Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University, Taipei, Taiwan. 88 Hirschsprung Disease and Its Mimickers: A Detailed Histomorphological Study of 12 Cases (648) Maria Bukelo, Amanda C Pinto, Suravi Mohanty, P Divya, N B Nandeesh, K M Babu, Usha Kini. St. John s Medical College, Bengaluru, Karnataka, India. 89 KRAS and VEGF Gene 3 -UTR Single Nucleotide Polymorphisms Predicted Susceptibility in Colorectal Cancer (835) Xiuli Xiao, Minnan Yang, Xin Li, Tian Xia, Hanan Long. The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. 90 Epstein Barr Virus and Its Association with Fascin Expression in Colorectal Cancers in Syrian Population: A Tissue Microarray Study (681) Hanan Farghaly, Noor Al-Antary, Ala-Eddin Al- Moustafa. Hamad Medical Corporation (HMC), Doha, Qatar; Qatar College of Medicine, Doha, Qatar. 91 Significance of Positive and Inhibitory Regulators in the TGF-β Signaling Pathway in Colorectal Cancers (666) Ryan Coates, Juli-Anne Gardner, Valerie Cortright, Jeannette Mitchell, Takamaru Ashikaga, Joan Skelly, Michelle X Yang. University of Vermont Medical Center, Burlington, VT. 92 Potential Biomarkers to Delineate Tumors of Pancreatic Origin (665) Ryan Coates, Valerie Cortright, Jeannette Mitchell, Abiy Ambaye, Michelle X Yang. University of Vermont Medical Center, Burlington, VT. 94 PD-L1 Expression in DNA Mismatch-Repair-Deficient and Medullary-Type Ampullary Carcinomas (837) Yue Xue, Gabriel Sica, Takashi Muraki, Bahar Memis, Serdar Balci, Cynthia Cohen, Brian Quigley, Alyssa Krasinskas, Michelle D Reid, Volkan Adsay. Emory University Hospital, Atlanta, GA. 95 Gastroblastoma Harbors Recurrent Somatic MALAT1- GLI1 Fusion Gene (689) Rondell Graham, Asha Nair, Jaime Davila, Long Jin, Patrick P Bedroske, Jin Jen, William R Sukov, Tsung- Teh Wu, Henry D Appelman, Jorge Torres-Mora, Kyle D Perry, Lizhi Zhang, Andrew L Folpe. Mayo Clinic, Rochester, MN; University of Michigan, Ann Arbor, MI. 96 Identification and Prognostic Significance of Genetic Drivers of Adenosquamous Carcinoma of Pancreas (809) Belinda Sun, Paris J Vail, Erik S Knudsen, Agnieszka K Witkiewicz. Banner-University Medical Center, University of Arizona, Tucson, AZ; University of Arizona, Tucson, AZ. 97 Lack of Prognostic Significance of HER2 Expression Profile in Colorectal Carcinoma (627) Jaudah A Al-Maghrabi, Abdelbaset Buhmeida, Mourad Assidi, Basim J Al-Maghrabi, Ashraf Dallol, Adeel Chaudhary, Adel Abuzenadah, Mahmoud S Al-Ahwal, Mohammed H Al-Qahtani. Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; King Abdulaziz University, Jeddah, Saudi Arabia. 98 HER2 Expression Is Predominantly Negative in GEJ and Gastric Adenocarcinoma with Signet Ring Cell Differentiation; Study of 346 Cases (719) Heewon Kwak, Tze S Khor, Lindsay Alpert, Daniel Catenacci, Shu-Yuan Xiao, John Hart, Namrata Setia, Priyanthi Kumarasinghe. University of Chicago, Chicago, IL; University of Western Australia, Crawley, WA, Australia. 99 High Level Microsatellite Instability in Appendiceal Carcinomas (684) Wai Chin Foo, Michael Overman, Eduardo Vilar Sanchez, Susan Abraham, Melissa Taggart. M.D. Anderson Cancer Center, Houston, TX. 220

281 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Assessment of PD-L1 Expression in Tumor Microenvironment of Mismatch Repair Deficient Colon Cancer: Comparing Two Antibody Clones, SP142 vs. SP263 (656) Zongming E Chen, Angela Bitting, Fan Lin. Geisinger Medical Center, Danville, PA. 101 Clinicopathologic Features of Low-Grade Appendiceal Mucinous Neoplasms: A Single-Institution Experience of 104 Cases (699) Aaron R Huber, Jennifer J Findeis-Hosey, Raul S Gonzalez. University of Rochester Medical Center, Rochester, NY. 102 Next Generation Sequencing Identifies Mutational Distinction Between Primary and Metastatic Colorectal Carcinoma: Potential Therapeutic Implications (734) Jean Lopategui, Snehalkumar B Patel, Navid Farahani, Myriam Chevarie-Davis, Mark D Ewalt, Andy Pao, Angela Aguiluz, Robert E Bookstein. Cedars-Sinai Medical Center, Los Angeles, CA. 103 IBD Specific Phenotypes of Colorectal Carcinomas Are Associated with Unique Molecular Alterations (710) Melanie E Johncilla, Neal I Lindeman, Mikhail Lisovsky, Amitabh Srivastava. Brigham and Women s Hospital, Boston, MA; Dartmouth-Hitchcock Medical Center, Lebanon, NH. 104 HER2/ ERBB2 Amplification in Colorectal Carcinoma Is Associated with KRAS Wild Type Status, Microsatellite Stability, and Left Sided Tumors (668) Paolo Cotzia, Deepu Alex, Sumit Middha, Jaclyn Hechtman, Sandy Liu, Deepthi Rao, Efsevia Vakiani, David S Klimstra, Jinru Shia. Memorial Sloan Kettering Cancer Center, New York, NY. 105 Concordance Between Mismatch Repair Status from Primary Colorectal Carcinoma and Distant Metastasis (663) Lani K Clinton, Thomas Plesec. Cleveland Clinic, Cleveland, OH. 106 ALDH Expression in Serrated Polyps Highlights the Role of Stem Cells (685) Danielle Fortuna, Bruce Boman, Juan P Palazzo. Thomas Jefferson University Hospital, Philadelphia, PA. 107 Mucinous Variant of Intrahepatic Cholangiocarcinoma: A Clinicopathological and Immunochemical Study (657) Zhikai Chi, Amarpreet Bhalla, Hanlin L Wang, Deepa T Patil, Jingmei Lin. Indiana University School of Medicine, Indianapolis, IN; University of California David Geffen School of Medicine, Los Angeles, CA; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland, OH. 108 Peritumoral Lymphoid Cuff in Gastrointestinal Schwannomas Is Significantly Correlated with Regional Lymph Node Enlargement: A Study of 118 Consecutive Cases from a Single Institute (633) Hyunsik Bae, Ha Young Park, Jinah Chu, Michael Van Vrancken, Kyoung-Mee Kim. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Tulane University School of Medicine, New Orleans, LA. 109 Metastatic Malignancies to the Upper Gastrointestinal Tract Encountered on Endoscopic Biopsy: A Clinicopathologic Study (775) Vatsal Patel, Elham Nasri, Jesse L Kresak, Michael Feely. University of Florida, Gainesville, FL. GENITOURINARY PATHOLOGY 110 Novel Histological Finding: Adipose Tissue Is Prevalent within Penile Tunica Albuginea and Corpora Cavernosa. An Anatomical Study of 63 Specimens and Considerations for Cancer Invasion (1017) Ingrid M Rodriguez, Martin Cuevas, Arturo Silvero, Sofía Cañete-Portillo, Diego F Sanchez, Jose Barreto, Antonio Cubilla. Instituto de Patología e Investigación, Asunción, Paraguay; Facultad de Ciencias Médicas Universidad Nacional de Asunción, Asunción, Paraguay; Instituto de Previsión Social, Asunción, Paraguay. 111 Comparison of Pathologic and Outcome Features of Classical vs. Mixed (Hybrid) Verrucous Carcinoma (VC) of Penis. A Study of 59 Cases (1028) Diego F Sanchez, Fernando Soares, Isabel Alvarado- Cabrero, Gustavo C Guimaraes, Isabela W Cunha, Diana Piedras, Adriana Rodríguez-Gómez, Sofía Cañete-Portillo, Arturo Silvero, Martin Cuevas, Ingrid M Rodriguez, Antonio Cubilla. Instituto de Patología e Investigación, Asunción, Paraguay; Facultad de Ciencias Médicas Universidad Nacional de Asunción, Asunción, Paraguay; AC Camargo Cancer Center, Sao Paulo, Brazil; Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico; Instituto de Previsión Social, Asunción, Paraguay. 112 Geographic Comparison of Histological Subtypes and Outcome of Surgically Treated Penile Squamous Cell Carcinoma (SCC) Patients from Mexico and Brazil. A Study of 411 Cases (1029) Diego F Sanchez, Fernando Soares, Isabel Alvarado- Cabrero, Gustavo C Guimaraes, Isabela W Cunha, Diana Piedras, Adriana Rodríguez-Gómez, Sofía Cañete-Portillo, Arturo Silvero, Martin Cuevas, Ingrid M Rodriguez, Antonio Cubilla. Instituto de Patología e Investigación, Asunción, Paraguay; Universidad Nacional de Asunción, Asunción, Paraguay; AC Camargo Cancer Center, São Paulo, Brazil; CMN Siglo XXI, IMSS, Mexico City, Mexico. 221

282 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Regional Metastasis and Outcome in HPV-Related vs Non-HPV-Related Histological Subtypes of Penile Squamous Cell Carcinoma (1027) Diego F Sanchez, Fernando Soares, Gustavo C Guimaraes, Isabela W Cunha, Sofía Cañete-Portillo, Arturo Silvero, Martin Cuevas, Ingrid M Rodriguez, Antonio Cubilla. Instituto de Patología e Investigación, Asunción, Paraguay; Facultad de Ciencias Médicas Universidad Nacional de Asunción, Asunción, Paraguay; AC Camargo Cancer Center, Sao Paulo, Brazil; Instituto de Previsión Social, Asunción, Paraguay. 114 The Pathology of Death from Germ Cell and Testicular Neoplasia. Review from a Large Tertiary Center (1042) Glenda Scandura, Wendy Ansell, Michelle Greenwood, Jonathan Shamash, Daniel Berney. Queen Mary University, London, United Kingdom. 115 PLZF Is a Novel Sensitive and Specific Diagnostic Marker for Metastatic and Extragonadal Primary Yolk Sac Tumor (1075) Christina Wei, David Priemer, Muhammad Idrees, Manju Aron, Qi Yang, Loralee McMahon, Guang Q Xiao. USC, Los Angeles, CA; Indiana U, Indianapolis, IN; U Rochester, Rochester, NY. 116 Granulocytic Sarcoma of the Testis in Children: Histology, Immunohistochemistry, and Molecular Studies of 5 Cases of This Very Rare Location (847) Kristen Adams, Xinchun Zhou, Hend Abulsayen, Siraj M El Jamal, Ali G Saad. University of Mississippi Medical Center, Jackson, MS. 117 Testicular Hemangioma: A Single Institutional Experience (974) Steven A Mann, Thomas M Ulbright, Muhammad Idrees. Indiana University School of Medicine, Indianapolis, IN. 118 Myoid Gonadal Stromal Tumor of the Testis. An Immunohistochemical and Ultrastructural Study of Three Cases (879) Maurizio Colecchia, Giuseppe Renne, Roberta Rossi, Antonella Tosoni, Alessia Bertolotti, Salvatore Renne. Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; European Institute of Oncology, Milano, Italy; DSC L.Sacco, Milano, Italy. 119 Atypical Adrenal Adenomas: A Radiological and Pathological Study of 159 Cases (938) Ling Hui, Mohamed G Elbanan, Khaled M Elsayes, Miao Zhang. MD Anderson Cancer Center, Houston, TX. 120 Fibromyxoid Stromal Response (FMR) Is Associated with Perineural Invasion (PNI) in Penile Squamous Cell Carcinoma (1001) Will Penny, Steven Post, Charles Quick, Christina Stallworth, Roni Cox. UAMS, Little Rock, AR. 121 Adult Genitourinary Rhabdomyosarcomas: An Analysis of Neuroendocrine Differentiation (931) Loren P Herrera Hernandez, Sounak Gupta, Rafael E Jimenez, Sarah H Johnson, Farhad Kosari, Andrew L Folpe, John C Cheville. Mayo Clinic, Rochester, MN. 122 Paratesticular Rhabdomyosarcoma: An 18-Year Review of 32 Cases (1010) David Priemer, Shaoxiong Chen, Guang Q Xiao, Thomas M Ulbright, Muhammad Idrees. Indiana University, Indianapolis, IN; University of Southern California, Los Angeles, CA. 123 Polyoma Virus-Associated Urologic Malignancies in the Immunocompromised Setting: Report of 8 Cases (892) Michelle Don, Deepika Sirohi, Steven C Smith, Mahesha Vankalakunti, Jamie Koo, Shikha Bose, Mariza de Peralta-Venturina, Mahul B Amin, Daniel J Luthringer. Cedars-Sinai Medical Center, Los Angeles, CA; Virginia Commonwealth University Health System, Richmond, VA. 124 Genetic Profile of Ductal Adenocarcinoma of the Prostate (895) Lars Egevad, Amanda H Seipel, Thomas Whitington, Brett Delahunt, Hemamali Samaratunga, Peter Wiklund, Henrik Grönberg, Johan Lindberg. Karolinska Institutet, Stockholm, Sweden; Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Aquesta Pathology, Brisbane, Australia. 125 Effect of Neoadjuvant Intense Androgen Deprivation Therapy in Neuroendocrine Differentiation of Prostate Cancer (987) Laleh Montaser, Carla Calagua, Rachel Schaefer, Rosina Lis, Zhenwei Zhang, Massimo Loda, Mary-Ellen Taplin, Steven P Balk, Huihui Ye. East Tennessee State University, Johnson City, TN; Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA. 126 Heterogeneity of Neuroendocrine Differentiation in Prostate Adenocarcinoma: A Study on Whole-Mount Radical Prostatectomy Specimens (1091) Menglei Zhu, Wei Chen, Sanjay Gupta, Gregory T MacLennan. University Hospitals Cleveland Medical Center, Cleveland, OH; Case Western Reserve University, Cleveland, OH; University Hospitals Cleveland Medical Center, Cleveland, OH. 127 Prostatic Adenocarcinoma (PCA) with Poorly Formed Gland (PFG) and Cribriform Morphology: Grade Group (GG), Canary Histologic Analysis, and 17-Gene Expression Assay Comparison in 218 Patients (903) Sara M Falzarano, Eric A Klein, Cristina Magi-Galluzzi, Jesse K McKenney. Cleveland Clinic, Cleveland, OH. 222

283 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall MRI-Targeted Prostate Biopsy Detects More Cribriform Prostate Carcinoma Than Standard Sextant Prostate Biopsy (1073) Ying Wang, Fang-Ming Deng, Hongying Huang, Peng Lee, Jonathan Melamed, Ming Zhou. New York University Langone Medical Center, New York, NY. 135 Identification of MicroRNA Signature for Aggressive Prostatic Adenocarcinoma (1081) Huiqing Wu, Xiwei Wu, Jennifer Jin, Tommy Tong, Przemyslaw Twardowski, Arthur Li, Chao Guo, Yuping Li, Rebecca Nelson, Young Kim, Jinhui Wang, Bertram Yuh. City of Hope, Duarte, CA. 129 Does MRI/Ultrasound Fusion Guided Biopsy Improve Prostate Cancer Detection? A Bi-Institutional Retrospective Study (991) Paari Murugan, Mariah Z Leivo, Dina El-Rayes, Ayman Soubra, Benjamin Spilseth, David Karow, Kellogg Parsons, Christopher Kane, Christopher Warlick, Badrinath Konety, Donna Hansel. University of Minnesota, Minneapolis, MN; University of California San Deigo, La Jolla, CA. 130 High Suspicion (HS) versus Low to Intermediate Suspicion (LIS) Comparison Using 3D Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Biopsies with Histopathologic Correlates (894) Zachary Dureau, Rachel Geller, Adeboye O Osunkoya. Emory University School of Medicine, Atlanta, GA. 131 Symmetrical Dominant Prostatic Carcinomas Are Higher Grade yet Less Likely to Recur After Radical Prostatectomy Compared to Non-Symmetrical Prostate Carcinomas (1076) Grant Williams, William R Gesztes, Huai-Ching Kuo, Jennifer Cullen, Inger L Rosner, Shiv K Srivastava, Allen Burke, Isabell Sesterhenn. Uniformed Services University of the Health Sciences, Bethesda, MD; Center for Prostate Disease Research, Rockville, MD; Joint Pathology Center, Silver Spring, MD. 132 Effect of Neoadjuvant Intense Androgen Deprivation Therapy in PD-L1 Expression in Prostate Cancer (873) Carla Calagua, Kristin Shaw, Joshua Russo, Rachel Schaefer, Rosina Lis, Zhenwei Zhang, Massimo Loda, Mary-Ellen Taplin, Steven P Balk, Yue Sun, Huihui Ye. Beth Israel Deaconess Medical Center, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; Memorial Sloan-Kettering Cancer Center, New York, NY. 133 Should Reporting of Peri-Neural Invasion and Extra- Capsular Extension Be Mandatory in Prostate Cancer BiopsieS? Correlation with Outcome in 988 Cases Treated Conservatively (861) Daniel Berney, Amar Ahmad, Vishnu Parameshwaran, Peter Scardino, Henrik Moller, Jack Cuzick, Luis Beltran. Memorial Sloan Kettering Cancer Center, New York, NY; Queen Mary University of London, London, United Kingdom; Kings College London, London, United Kingdom. 134 Historic Gleason Score (GS) 3+5=8 (Grade Group (GG) 4) Prostate Cancer (PC) Has Low Reproducibility with 2014 ISUP Grading (956) Oleksandr N Kryvenko, Nouf Hijazi, Robert Poppiti, Paul J Taylor Smith, Merce Jorda, Jonathan I Epstein. University of Miami and Others, Miami, FL. 136 Overexpression of the Long Non-Coding RNA SChLAP1 in Prostate Cancer: Morphologic Distribution and Association with Intraductal and Cribriform Carcinoma (1009) Susan Prendeville, Winnie Lo, Melania Pintille, Robert Bristow, Theodorus van der Kwast. University Health Network, Toronto, ON, Canada; Princess Margaret Cancer Centre, Toronto, ON, Canada. 137 Integrative Genomics of Prostate Cancer Progression (882) Joanna Cyrta, Juan Miguel Mosquera, Brian Robinson, Andrea Sboner, Himisha Beltran, Daniel Hovelson, Scott A Tomlins, Ronglai Shen, Mark A Rubin. Weill Cornell Medicine, New York, NY; Univ. Michigan, Ann Arbor, MA; Memorial Sloan Kettering Cancer Center, New York, NY. 138 Validation of p53 Immunohistochemistry for Sensitive and Specific Detection of TP53 Mutation in Prostate Cancer (860) Liana Benevides Guedes, Fawaz Almutairi, Michael C Haffner, Gaurav Rajoria, Zach Liu, Szczepan Klimek, Roberto Zoino, Kasra Yousefi, Angelo M De Marzo, William Isaacs, Edward M Schaeffer, Ashley E Ross, Tamara L Lotan. Johns Hopkins University School of Medicine, Baltimore, MD; Pathline Emerge Pathology Services, Ramsey, NJ; GenomeDx Biosciences, Vancouver, BC, Canada. 139 Neurovascular Structure-Adjacent Frozen-Section Examination (NeuroSAFE) of Radical Prostatectomies Improves Negative Surgical Margin Rates (854) Samuel J Ballentine, G Kenneth Haines, Hinaben J Panchal, Avinash K Reddy, Ash Tewari, Qiusheng Si. Icahn School of Medicine at Mount Sinai, New York, NY. 140 Racial Disparity in Expression of GDF-15 and NF-kB in Prostate Cancer and Benign Prostate (955) Oleksandr Kravtsov, Malvika Solanki, James R Lambert, Kathleen Torkko, M Scott Lucia, Kenneth Iczkowski. Medical College of Wisconsin, Milwaukee, WI; University of Colorado, Aurora, CO. 141 Clinicopathologic Features and Outcome in Primary T2 Prostatic Urethral Urothelial Carcinomas at a Single Academic Institution: Is There a Role for Substaging? (908) Joel Friedman, Aaron M Udager, Rohit Mehra, Scott A Tomlins, Lakshmi P Kunju, Angela Wu. University of Michigan Health System, Ann Arbor, MI. 223

284 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Cyclin D1 Immunoexpression in Urinary Bladder Carcinoma Is Associated with Stage, Grade and Survival (851) Basim J Al-Maghrabi, Mohamad N Khabaz, Taoufik Nedjadi, Jaudah A Al-Maghrabi. King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. 143 Role of SATB2 in Distinguishing the Site of Origin in Glandular Lesions of the Bladder/Urethra: An Immunohistochemical Study (913) Giovanna Giannico, Allen M Gown, Jonathan I Epstein, Justin A Bishop. Vanderbilt University Medical Center, Nashville, TN; PhenoPath Laboratories, Seattle, WA; Johns Hopkins Medical Institutions, Baltimore, MD. 144 PD-L1 in Tumor Cells and the Immunologic Milieu of Bladder Carcinomas: A Pathologic Review of 177 Cases (889) Jonathan J Davick, Henry F Frierson, Alejandro Gru. University of Virginia, Charlottesville, VA. 145 Mcl-1 Protein Overexpression and MCL1 Gene Amplification in Urothelial Carcinoma of the Urinary Bladder (944) Bhaskar VS Kallakury, Sungeun Kim, Christine E Sheehan, Tipu Nazeer, Jeffrey Ross. Georgetown University Hospital, Washington, DC; Albany Medical College, Albany, NY. 146 Variant Histologies Are Common in Urinary Tract Cancers with Positive Polyomavirus (SV40) Antigen Immunohistochemistry (1044) Alpa B Shah, Nilesh S Gupta, Sean R Williamson. Henry Ford Hospital, Detroit, MI. GYNECOLOGIC AND OBSTETRIC PATHOLOGY 150 Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma (1148) Qiong Gan, Suzanne Crumley, Russell R Broaddus. MD Anderson Cancer Center, Houston, TX. 151 Expression of SALL4 in Undifferentiated Endometrial Carcinoma and Correlation with Outcome (1150) Qiong Gan, Preetha Ramalingam. MD Anderson Cancer Center, Houston, TX. 152 High-Grade Endometrial Carcinomas Show Frequent Aberrant Expression of Yolk Sac Markers (1106) Keegan Barry-Holson, Chieh-Yu Lin, Ann Folkins. Stanford University School of Medicine, Stanford, CA. 153 Endometrial Carcinoma with Trophoblastic Differentiation: A Clinicopathologic Analysis of 24 New and Previously Reported Cases (1224) Kojo Rawish, Natalia Buza, Wenxin Zheng, Oluwole Fadare. Vanguard Pathology Associates, Austin, TX; Yale University, New Haven, CT; UTSW, Dallas, TX; UCSD, San Diego, CA. 154 Endometrial Biopsy of Dedifferentiated and Undifferentiated Endometrial Carcinoma, Emphasizing Useful Diagnostic Features in Under-Sampled Tumors That Otherwise Appear as Low Grade Endometrioid Adenocarcinoma (1171) Amy S Joehlin-Price, Joseph Rabban. UCSF, San Francisco, CA. 155 Inter-Observer Agreement for Measurement of Absolute Depth of Invasion in Endometrial Adenocarcinomas Using Light Microscopy and Whole Slide Scanning (1179) Rossana Kazemimood, Andres Acosta, Farid Saei Hamedani, Shohreh Eliaszadeh, Rajyasree Emmadi, John Groth, Elizabeth Wiley. University of Illinois at Chicago, Chicago, IL. 147 Squamous Morules: Re-Examination of a Well-Known Entity An Ultrastructural and Immunohistochemistry Study (1273) Jinjun Xiong, Yihong Wang, Margaret M Steinhoff, C James Sung, M Ruhul Quddus, Grant A Jolly, W Dwayne Lawrence, Katrine Hansen. Women & Infants Hospital, Providence, RI; Rhode Island Hospital, Providence, RI; Brown University Alpert Medical School, Providence, RI. 148 Uterine Polyps in the Setting of Tamoxifen Use: An Institutional Experience (1157) Lisa Han, Ricardo R Lastra. University of Chicago, Chicago, IL. 149 BMI and Differential Epithelial and Stromal ER/PR Expression within Type I and Type II Endometrial Carcinoma (1219) Joseph Peevey, Kruti P Maniar, Ji-Yong Julie Kim. Northwestern Memorial Hospital, Chicago, IL. 156 Sentinel Lymph Node Ultrastaging as a Supplement for Endometrial Cancer Intraoperative Frozen Section Deficiencies (1112) Morgan Blakely, Yuxin Liu, Jamal Rahaman, Monica Prasad-Hayes, Navya Nair, Tamara Kalir. Mount Sinai Hospital Icahn School of Medicine, New York, NY. 157 Treatment of Symptomatic Uterine Fibroids with Ulipristal Acetate: Endometrial Safety (1121) William Catherino, Carol Eisenhut, Rick Blakesley, Anna Chan, Vilma Sniukiene, Steven Goldstein. Uniformed Services University of the Health Sciences, Bethesda, MD; DCL Pathology, Indianapolis, IN; Allergan plc, Jersey City, NJ; New York University School of Medicine, New York, NY. 224

285 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Mitotically Active Uterine Leiomyomata Exhibit Similar Clinical Outcomes to Conventional Leiomyomata: A Clinicopathologic Study with Long-Term Follow-Up (1268) Elizabeth Yiru Wu, Yin (Rex) Hung, Marisa R Nucci, Bradley J Quade. Brigham and Women s Hospital, Boston, MA. 159 Major Vault Protein Immunohistochemistry Is a Useful Adjunct in Distinguishing Leiomyosarcoma from Leiomyoma and Leiomyoma with Bizarre Nuclei (1197) Nicholas Lintel, Scott A Koepsell, Jesse Cox, Stephen A Luebker, Subodh M Lele. University of Nebraska Medical Center, Omaha, NE; Nebraska Medicine, Omaha, NE. 160 MED12 Mutation in Uterine Adenomyoma (1182) Masahiko Kito, Daichi Maeda, Yukihiro Terada, Akiteru Goto. Akita University, Akita, Japan. 161 Primary Angioleiomyoma of the Female Genital Tract: A Clinicopathologic Analysis of 20 Cases (1214) Kristen E Muller, Amir Lagstein. University of Michigan, Ann Arbor, MI. 162 Clinicopathologic and Molecular Analysis of 25 Cases of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP) (1257) Brandon Umphress, Qing Zhang, Jian-Jun Wei. Northwestern University Feinberg School of Medicine, Chicago, IL; Shandong University, Jinan, Shandong, China. 163 Frequent Non-Syndromic Deletion and Transcript Reduction of COL4A5 and COL4A6 in Uterine Leiomyosarcoma (1222) Bradley J Quade, Liping Yuan, Marisa R Nucci, Brooke E Howitt. Brigham and Women s Hospital and Harvard Medical School, Boston, MA. 164 TERRA Amplified (+) Primary Leiomyosarcomas (LMS) of the Gynecologic (GYN)-Tract (1266) Adele Wong, Kshitij S Arora, Zehra Ordulu, Vikram Deshpande, Esther Oliva. Massachusetts General Hospital, Boston, MA; KK Women s and Children s Hospital, Singapore, Singapore. 165 Androgen Receptor Expression, Androgen Receptor CAG Repeat Polymorphism and X-Chromosome Inactivation Patterns in Uterine Leiomyomas & Leiomyosarcoma: Imunohistochemical and Molecular Study (1096) Nisreen Abu Shahin, Amani Albustanji, Ali Alkhader, Mamoun Ahram. University of Jordan, Amman, Jordan. 166 IFITM1 Outperforms CD10 in Differentiating Low Grade Endometrial Stromal Sarcomas from Smooth Muscle Neoplasms (1117) Aurelia Busca, Carlos Parra-Herran, Previn Gulavita, Shahid Islam. University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada; University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada; University of Ottawa and Montfort Hospital, Ottawa, ON, Canada. 167 Extrapelvic Metastatic Endometrial Stromal Sarcoma: A Bi-Institutional Review (1105) Nick Baniak, Scott Adams, Rajni Chibbar, Rani Kanthan. University of Saskatchewan, Saskatoon, SK, Canada. 168 Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor IGFBP5-ALK and THBS1-ALK Fusions (1189) Cheng-Han Lee, Josh Haimes, Brian Kudlow, Jen-Chieh Lee, W Glenn McCluggage, Tony Ng, Colin J Stewart. Vancouver General Hospital and BC Cancer Agency, Vancouver, Canada; ArcherDX, Inc, Boulder, CO; National Taiwan University Hospital, Taiepi, Taiwan; Belfast Health and Social Care Trust, Belfast, United Kingdom; King Edward Memorial Hospital, Perth, Australia. 169 Uterine Rhabdomyosarcoma in Adults: A Clinicopathologic Study of Five Cases (1221) Andre Pinto, Ryan Kahn, Darcy A Kerr, Andrew E Rosenberg, Brian Slomovitz, Breelyn Wilky, Marilyn Huang. University of Miami, Miami, FL. 170 High Grade Mullerian Adenosarcoma: Genomic and Clinicopathologic Characterization Indicative of a Distinct Neoplasm with Aggressive Behavior (1159) Anjelica Hodgson, Yutaka Amemiya, Arun Seth, Bojana Djordjevic, Carlos Parra-Herran. Sunnybrook Health Sciences Centre University of Toronto, Toronto, ON, Canada. 171 DICER1 Mutations in Müllerian Adenosarcomas (1108) Gregory Bean, Gregor Krings, Karuna Garg. UCSF, San Francisco, CA. 172 Frequent Aneuploidy Detection in Non-Molar Abortuses by Molecular Analysis of Products of Conception with Atypical Villus Morphology (1133) Jessica Dillon, Jorge L Gonzalez, W T Parks, Laura Tafe. Dartmouth Hitchcock Medical Center, Lebanon, NH. 173 Excessive Placental Macrocalcifications: Role in Pregnancy Outcome (1116) Tatiana N Buhtoiarova, Jennifer Zeng, Khush Mittal. UH Parma, Parma, OH; NYU Langone Medical Center, New York, NY. 225

286 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall E-Cadherin/CD34 Dual Immunohistochemical Stain in Search for Placental Focal Fetal Vascular Malperfusion (1172) Sheryl L Johnson, Jerzy Stanek. Cincinnati Children s Hospital Medical Center, Cincinnati, OH. 175 Mature Trophoblasts of the Maternal Interface Have a Low Proliferative Index in Placenta Creta (1247) Kyle C Strickland, Jelena Mirkovic, Carlos Parra-Herran, Bradley J Quade, Daniela A Carusi. Brigham and Women s Hospital, Harvard Medical School, Boston, MA; University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 183 Comparison of p63 and p40 Immunohistochemical Stains to Distinguish Epithelioid Trophoblastic Tumor from Other Trophoblastic Lesions (1206) Whitney A McCarthy, Cherie Paquette, W Dwayne Lawrence. Women and Infants Hospital of Rhode Island/Warren Alpert Medical School of Brown University, Providence, RI. 184 Choriocarcinoma in Women: Analysis of a Case Series with Genotyping (1231) Johanna Savage, Kathleen M Murphy, Brigitte M Ronnett. Johns Hopkins Medical Institutions, Baltimore, MD; ProPath, Dallas, TX. 176 Placental Lesions in Meconium Aspiration Syndrome (1181) Binnari Kim, Jung-sun Kim, Soo-young Oh. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 177 Placental Mesenchymal Dysplasia: A Clinicopathological Study of 12 Cases with Gestational Ages Less Than 20 Weeks (1145) Masaharu Fukunaga. Shin-Yurigaoka General Hospital, Kawasaki, Japan. 178 Clinicopathological and Immunohistochemical Studies of Twin Placenta with Complete Hydatidiform Mole (1147) Masaharu Fukunaga. Shin-Yurigaoka General Hospital, Kawasaki, Japan. 179 Complete Hydatidiform Moles with Mosaic Histology: Histological and Immunohistochemical Studies of Ten Cases (1146) Masaharu Fukunaga. Shin-Yurigaoka General Hospital, Kawasaki, Japan. 180 Placental Site Nodule, Atypical Placental Site Nodule and Epithelioid Trophoblastic Tumor: Clinical- Pathologic Characterization and Comparison of Trophoblastic and Stromal Cell Populations (1210) Jelena Mirkovic, Elizabeth Kehr, Brooke E Howitt, Christopher P Crum, Carlos Parra-Herran. Brigham and Women s Hospital, Boston, MA; Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 181 Gestational Trophoblastic Tumors Are Characterized by FOSB Expression (1211) Jelena Mirkovic, Bradley J Quade, Jason L Hornick, Michelle S Hirsch. Brigham and Women s Hospital, Boston, MA. 182 Targeted Genomic Profiling and PD-L1 Expression in Epithelioid Trophoblastic Tumors and Placental Site Trophoblastic Tumors (1212) Jelena Mirkovic, Elizabeth Garcia, Lynette M Sholl, Neal I Lindeman, Laura E MacConaill, Fei Dong, Bradley J Quade, Neil S Horowitz, Christopher P Crum, Brooke E Howitt. Brigham and Women s Hospital, Boston, MA. HEMATOPATHOLOGY 185 Role of Complexity of Variant Philadelphia Chromosome in Chronic Myeloid Leukemia (1407) Zimu Gong, Zhenya Tang, Zi Chen, Wei Wang, Shi Bai, Guilin Tang, L Jeffrey Medeiros, Shimin Hu. MD Anderson Cancer Center, Houston, TX. 186 inv(3)/t(3;3)(q21;q26) in Blast Phase of Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitor Therapy (1357) Shi Bai, Zi Chen, Wei Wang, Zhihong Hu, L Jeffrey Medeiros, Shimin Hu. MD Anderson Cancer Center, Houston, TX. 187 Cytogenetic Landscape and Impact in Blast Phase of Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitor Therapy (1373) Zi Chen, Wei Wang, L Jeffrey Medeiros, Shimin Hu. MD Anderson Cancer Cancer, Houston, TX. 188 Requirement of Depth of Treatment Response for Optimal Outcome in Patients with Blast Phase of Chronic Myeloid Leukemia (1374) Zi Chen, L Jeffrey Medeiros, Zimu Gong, Lan Zheng, Keyur P Patel, Wei Wang, Shimin Hu. MD Anderson Cancer Center, Houston, TX. 189 Clinical Value of Targeted Panel Next-Generation Sequencing in BCR-ABL1-Negative Myeloproliferative Neoplasms (1550) Tong Yang, Adrian Box, Elliott Winton, Charles E Hill, Linsheng Zhang. Emory University School of Medicine, Atlanta, GA q26.2 Rearrangements Are Associated with a Poor Prognosis in Ph-Negative Myeloproliferative Neoplasms (1423) Zhihong Hu, Wei Wang, Zi Chen, Zimu Gong, Parsa Hodjat, Shi Bai, Guilin Tang, L Jeffrey Medeiros, Shimin Hu. The University of Texas MD Anderson Cancer Center, Houston, TX. 226

287 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Survey of CALR Mutations in Patients with Suspected Myeloproliferative Neoplasms (1448) Wenyi Luo, Richard A Allen, Wanting Ho, Zhongxin Yu, Zhizhuang Zhao. University of Oklahoma Health Sciences Center, Oklahoma City, OK. 192 Acute Leukemia Arising from Myeloproliferative Neoplasm: Clinicopathologic Studies of 35 Cases (1442) Xin Liu, Endi Wang. Duke University Medical Center, Durham, NC. 193 Clinical Significance of Cytogenetic Abnormalities in Polycythemia Vera (1418) Juliana E Hidalgo Lopez, Sa Wang, L Jeffrey Medeiros, Carlos E Bueso-Ramos, Guilin Tang. MD Anderson Cancer Center, Houston, TX. 194 Blast Phase of Polycythemia Vera (1446) Juliana E Lopez-Hidalgo, Adrian A Carballo-Zarate, L J Medeiros, Carlos E Bueso-Ramos, Guilin Tang. MD Anderson Cancer Center, Houston, TX. 195 Morphological and Clinical Findings in Progressive Polycythemia Vera: Definition of Post-PV MF and Correlation to Treatment Resistance (1435) Hans Michael Kvasnicka, Gina Liviana Frank, Juergen Thiele. University of Frankfurt, Frankfurt, Germany; University of Cologne, Cologne, Germany. 196 Integrated Molecular and Histologic Analysis Identifies Distinctive Gene Expression Patterns in Primary Myelofibrosis (1546) Waihay J Wong, Michele T Baltay, Frank C Kuo, Kit Fuhrman, Robert P Hasserjian, Olga Pozdnyakova. Brigham and Women s Hospital, Boston, MA; Massachusetts General Hospital, Boston, MA; Nanostring Technologies, Inc., Seattle, WA. 197 Myeloid Neoplasms with Morphologic and Molecular Features Intermediate Between PMF and CMML (1369) Jennifer Chapman, Francisco Vega, Adrienne Moul, Mahsa Khanlari, Julio C Poveda, Gabriel Villada, Offiong F Ikpatt, Julia T Geyer, Attilio Orazi. University of Miami, Miami, FL; Weill Cornell Medicine, New York, NY. 198 JAK2 p.v617f Mutations Are Common in Chronic Myelomonocytic Leukemia with Fibrosis (1416) Deniz Gur, Sanam Loghavi, Mark J Routbort, Guillermo Garcia-Manero, Cameron Yin, Shaoying Li, L Jeffrey Medeiros, Joseph D Khoury. The University of Texas MD Anderson Cancer Center, Houston, TX. 199 Differential Proteomic Signatures in Chronic Myelomonocytic Leukemia Subsets Identified by Reverse Phase Protein Array Analysis (1445) Sanam Loghavi, Zhuang Zuo, Deniz Gur, Hong Yang, Xiaomei Lu, Carlos E Bueso-Ramos, L Jeffrey Medeiros, Joseph Khoury. The University of Texas, MD Anderson Cancer Center, Houston, TX. 200 Clinicopathologic Features of Hairy Cell Leukemia Variant: An Experience of 21 Cases (1353) Evgeniya A Angelova, Zhihong Hu, Deniz Gur, Tariq Muzzafar, Wei Wang, L Jeffrey Medeiros. The University of Texas MD Anderson Cancer Center, Houston, TX. 201 IgM Multiple Myeloma in the Era of Novel Therapy: Clinicopathologic Study of 14 Cases (1352) Evgeniya A Angelova, Xinyan Lu, Shaoying Li, L Jeffrey Medeiros, Pei Lin. The University of Texas MD Anderson Cancer Center, Houston, TX. 202 c-myc Protein Expression Distinguishes Plasma Cell Myeloma from Solitary Plasmacytoma and Is Associated with Aggressive Morphologic Features (1473) Jean Oak, Philipp W Raess, Carolyn Foley, Robert Ohgami, Michael Cascio. Stanford University, Stanford, CA; Oregon Health & Science University, Portland, OR. 203 Co-Treatment of Bortezomib and PRIMA-1 Met Synergistically Overcomes Drug Resistance by Down-Regulating Pro-Survival Autophagy in Multiple Myeloma (1537) Minjing Wang, Lun Zhang, Nasrin Rastgoo, Jahangir Abdi, Hong Chang. University Health Network, Toronto, ON, Canada. 204 Eosinophilia of the Bone Marrow in Multiple Myeloma Correlates with Higher Plasma Cell Burden, Relapsing/ Remitting Course, and Shorter Interval to Progression (1377) Natalie A Ciomek, Reiri Sono, Deepu Madduri, Bart Barlogie, Julie Teruya-Feldstein. Icahn School of Medicine at Mount Sinai, New York, NY. 205 High CD47 Protein Expression Is Associated with Inferior Survival in Patients with Multiple Myeloma (1487) Maryam Pourabdollah, Mohammad Bahmanyar, Eshetu G Atenafu, Donna Reece, Hong Chang. University Health Network, Toronto, ON, Canada. 206 Crystal-Storing Histiocytosis in Bone Marrow: An Uncommon Phenomenon with Protean Manifestations (1375) April Chiu, Erica F Reinig, Pedro Horna, Kaaren K Reichard. Mayo Clinic, Rochester, MN. 227

288 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Lymph Node Fibrosis in IgG4-Related Disease (1362) Leonardo Boiocchi, Judith A Ferry, Vikram Deshpande. Massachusetts General Hospital, Boston, MA. 208 Programmed Death-1 (PD-1) and Programmed Death- Ligand 1 (PD-L1) Expression in Aggressive Pediatric Lymphomas (1379) Amy M Coffey, Jonathan L Curry, Andrea N Marcogliese, Michael T Tetzlaff, Kala Kamdar, Mohamed T Elghetany, Choladda V Curry. Baylor College of Medicine and Texas Children s Hospital, Houston, TX; The University of Texas MD Anderson Cancer Center, Houston, TX. 209 Error-Corrected Circulating Tumor DNA Sequencing in Non-Hodgkin Lymphoma (1496) Meghan Riley, Grace Tiska, Kilannin Krysiak, Felicia Gomez, Amanda Cashen, Nancy Bartlett, Obi Griffith, Malachi Griffith, Todd Fehniger, Matthew Walter, Eric Duncavage. Washington University, St. Louis, MO. 210 Composite, Synchronous and Metachronous Lymphomas of B and T Cell Lineage: A Retrospective Analysis (1410) Tanu Goyal, Eric D Hsi. Cleveland Clinic Foundation, Cleveland, OH. 211 Lymphoma of the Liver: Clinicopathological Features of 19 Patients (1482) Yue Peng, Changjun Yue, Samuel W French, Xin Qing. Harbor-UCLA Medical Center, Torrance, CA. 212 Sequencing Fragments Rather Than the Entire IGHV Affects the Prognostic Reliability in Chronic Lymphocytic Leukemia (1424) Chad Hudson, Jan Spence, Madalynn Bryant, Richard Burack. University of Rochester School of Medicine, Rochester, NY. 213 Typical and Atypical Chronic Lymphocytic Leukemia: A Molecular Level Comparison (1427) Zena Jameel, Weiyi Chen, Shahida Ahmed, Donghong Cai. Rutgers New Jersey Medical School, Newark, NJ; Cancer Genetics Inc., Rutherford, NJ; VA New Jersey Medical Center, East Orange, NJ. 214 Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma with Prominent Proliferation Centers in Bone Marrow Is Associated with High Tumor Burden and TP53 Deletion (1403) Sofia Garces, L Jeffrey Medeiros, Alireza Salem, Sa Wang, Carlos E Bueso-Ramos, Joseph Khoury, Sanam Loghavi. The University of Texas MD Anderson Cancer Center, Houston, TX. 215 Aberrant Expression of Germinal Center Markers in Mantle Cell Lymphoma (1486) Marco Pizzi, Simona Righi, Anna Gazzola, Claudia Mannu, Francesca Galuppini, Massimo Rugge, Elena Sabattini. University of Padova, Padova, Italy; Sant Orsola- Malpighi Hospital, Bologna, Italy. 216 CD10-Positive Mantle Cell Lymphoma: Clinicopathologic and Prognostic Study of 28 Cases (1549) Jie Xu, Annapurna Saksena, Jiehao Zhou, Jingyi Li, Cameron Yin, Guilin Tang, L Jeffrey Medeiros, Shaoying Li. University of Texas MD Anderson Cancer Center, Houston, TX; Indiana University, Indianapolis, IN. 217 CD23+ Mantle Cell Lymphoma: A Clinicopathologic Analysis of 59 Cases (1500) Annapurna Saksena, Jingyi Li, C Cameron Yin, Michael Wang, Pei Lin, Jiehao Zhou, Roberto N Miranda, L Jeffrey Medeiros, Shaoying Li. MD Anderson Cancer Center, Houston, TX; UT Health Science Center, San Antonio, TX; Indiana University, Indianapolis, IN. 218 CD5-Negative Mantle Cell Lymphoma Shows a More Indolent Outcome and Variable SOX11 Staining (1513) Angela Shih, Jacob R Bledsoe, Penny McKelvie, Nancy Harris, Lawrence Zukerberg. Massachusetts General Hospital, Boston, MA. 219 Expansion of PD-1-Positive T-cells in Nodal Marginal Zone Lymphoma (MZL) A Diagnostic Pitfall (1390) Caoimhe Egan, Camille Laurent, Michael E Kallen, Stefano Pileri, Elias Campo, Steven H Swerdlow, Miguel Piris, Wing C Chan, Roger Warnke, Randy Gascoyne, Mark Raffeld, Stefania Pittaluga, Elaine S Jaffe. National Institutes of Health, Bethesda, MD; Institut Universitaire du Cancer-Oncopole, Toulouse, France; European Institute of Oncology, Milan, Italy; University of Barcelona, Barcelona, Spain; University of Pittsburgh, Pittsburgh, PA; Hospital Universitario Marqués de Valdecilla, Santander, Spain; City of Hope Medical Center, Duarte, CA; Stanford University, Stanford, CA; British Columbia Cancer Agency, Vancouver, BC, Canada. 220 Programmed Cell Death Ligand 1 (PD-L1) Expression in the Follicular Lymphoma Microenvironment (1545) Jerry T Wong, Maryam D Ameri, Parwiz Siaghani, David Cantu, Yuan Yuan Chen, Joo Song, Dennis D Weisenburger, Young Kim. City of Hope National Medical Center, Duarte, CA. 221 ERG, a Vascular/Lymphatic Endothelial Marker, Is Expressed in Follicular Lymphoma and a Subset of Diffuse Large B-Cell Lymphoma (1552) Shanxiang Zhang, Vinushree Swamy, Lin Wang, Liang Cheng. Indiana University School of Medicine, Indianapolis, IN. 228

289 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall MiRNA Profiling Reveals a Specific Signature for Germinal Center Derived B-cell Lymphomas (1380) Stefan Costinean, Aisha Al-Khinji, Ellen Leich, Tathiana Azevedo de Andrade, Alyssa Bouska, Waseem Lone, Andreas Rosenwald, Wing C Chan, Kai Fu, Javeed Iqbal. University of Nebraska Medical Center, Omaha, NE; Department of Wuerzburg, Wuerzburg, Germany; Universidade Fedral De Sao Paulo, Sao Paulo, Brazil; City of Hope, Duarte, CA. 223 Selective Loss of PTEN Expression in Germinal Center-Derived B Cell Lymphomas Lacking Surface Immunoglobulin (1430) Hani Katerji, Richard Burack, Andrew Evans. University of Rochester, Rochester, NY. 224 The Life and Death of the Germinal Center: An Immunohistochemical Analysis (1470) Dennis P O Malley. Clarient/NeoGenomics, Aliso Viejo, CA; Stanford University, Palo Alto, CA. LIVER 225 Reduced Androgen Receptor Expression Supports the Diagnosis of Hepatocellular Carcinoma (1664) Craig Cousineau, Ping L Zhang, Zhenhong Qu. Beaumont Health, Royal Oak, MI. 226 ABHD 6 Immunostain Identifies a New Molecular Pathway Implicated in Human Hepatocellular Carcinoma Pathogenesis (1655) Daniela Allende, Federico Aucejo, Mohammed Elshamy, Abdulrahman Hammad, Christopher Lanigan, J Mark Brown. Cleveland Clinic, Cleveland, OH. 227 Arginase-1 (Arg-1) Is a Specific but Not Sensitive Immunohistochemical Marker for Hepatocellular Carcinoma (HCC) (1697) Faisal Saeed, Esther C Yoon, Taliya Farooq, Yasmin Yusuf, Minghao Zhong. New York Medical College at Westchester Medical Center, Valhalla, NY. 228 Diagnostic Value of Clusterin Immunostaining in Hepatocellular Carcinoma: A Comparison with pcea and CD10 (1711) Sharon S Zhang, Fangfang Liu, Jianhui Shi, Peiguo Chu, Fan Lin, Adam Stelling, Hong Shen, Hanlin L Wang. David Geffen School of Medicine at UCLA, Los Angeles, CA; Geisinger Medical Center, Danville, PA; City of Hope National Cancer Center, Duarte, CA. 229 Multifocal Hepatocellular Carcinoma with Features Suggestive of Intrahepatic Metastases: Clinical, Histological and Radiological Correlation (1674) Yanfei Huang, Xiuli Liu, Ashwini K Esnakula. University of Florida, Gainesville, FL. 230 In-Situ Hybridization for Glypican-3 RNA Is More Sensitive Than Immunohistochemistry in Hepatocellular Carcinoma (1679) Michael Lee, Anne Koehne de Gonzalez, Helen E Remotti, Manoj Gandhi, Shauna Levinson, Vikram Deshpande, Stephen M Lagana. Columbia University, New York, NY; Affymetrix, Santa Clara, CA; Massachusetts General Hospital, Boston, MA. 231 Evaluation of Peritumoral Fibrosis in Metastatic Adenocarcinoma to the Liver Using Digital Image Analysis (1706) Kevin Waters, Tricia R Cottrell, Robert A Anders. Johns Hopkins Hospital, Baltimore, MD. 232 Adenovirus Hepatitis: Analysis of 12 Consecutive Cases at a Single Institution (1698) Kurt Schaberg, Neeraja Kambham, Richard Sibley, John P Higgins. Stanford University School of Medicine, Stanford, CA. 233 Liver Injury Induced by PD-1 Inhibitor Nivolumab: Report of 3 Cases with Biopsy Findings (1713) Xiaoyan Zhou, Bita V Naini, Noah C Federman, Guadulupe Garcia-Tsao, Elizabeth A Marcus, Robert S Venick, Laura J Wozniak, Xuchen Zhang, Hanlin L Wang. University of Los Angeles, Los Angeles, CA; Yale University, New Haven, CT. 234 Immunohistochemistry (IHC) as a Valuable Aid in the Detection of Early Oxaliplatin-Associated Liver Injury (1672) Rajib Gupta, Daniel Rowan, Karen Arispe, Alexander C Mackinnon, Kiyoko Oshima. Medical College of Wisconsin, Milwaukee, WI. 235 Diagnostic Utilities of Electronic Microscopy(EM) in Genetic and Metabolic Liver Diseases A Study of 105 Cases in Chinese Population (1710) Zichang Yin, Japing Zhang, Zhongren Zhou, Dongfeng Tan. KingMed College of Laboratory Medicine, Guangzhou, Guangdong, China; Univ of Rochester, Rochester, NY; MD Anderson Cancer Center, Houston, TX. 236 Non-Alcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease and Primary Sclerosing Cholangitis (1659) Dustin Bosch, Sarag Boukhar, Lisa Koch, Florencia Jalikis, Matthew M Yeh. U. of Washington, Seattle, WA. 237 Brown Stains for Identification of Ballooned Hepatocytes in Non-Alcoholic Steatohepatitis (NASH): Ready for Prime Time? (1668) Sadhna Dhingra, Ghazaleh Eskandari, Gagan Sood, Wengdong Yu, John Vierling, Romil Saxena. Indiana University School of Medicine, Indianapolis, IN; Baylor College of Medicine, Houston, TX. 229

290 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Necrosis Correlation Between Biopsy and Subsequent Hepatectomy in Fulminant Liver Failure (1683) Steven A Mann, Jingmei Lin. Indiana University School of Medicine, Indianapolis, IN. 239 Comparison of Donation After Cardiac Death (DCD) Liver Transplant Recipients with Hepatitis C (HCV) and Non-Hepatitis C Related Cirrhosis (1660) Kathleen Byrnes, Neeta Vachharajani, Maria M Doyle, ILKe Nalbantoglu. Washington University in St. Louis, St. Louis, MO. 240 Morphological Features of Early Acute Hepatitis Following Liver Transplantation for Hepatitis C Disease (1685) Carla Montironi, Patricia Llovet, Salvatore Sciarrone, Claudia Mescoli, Massimo Rugge, Martina Gambato, Patrizia Burra, Gonzalo Crespo, Xavier Forns, Alba Díaz. Hospital Clinic, Barcelona, Spain; Padua University Hospital, Padua, Italy. 241 Histologic Progression of Ischemic Cholangiopathy in Liver Allografts of Donation After Cardiac Death (1700) Matthew Schrage, Camtu D Truong, Lena Sibulesky, Paul E Swanson, Matthew M Yeh. University of Washington, Seattle, WA. 242 Current Diagnostic Thresholds for Acute Rejection in Liver Allograft Biopsies Are Adequate (1699) Kurt Schaberg, Neeraja Kambham, Richard Sibley, John P Higgins. Stanford University School of Medicine, Stanford, CA. 243 Frozen Section Artifact May Hinder Assessment of Steatosis in Pretransplant Liver Biopsies (1702) Meenal Sharma, Jennifer J Findeis-Hosey. Univ. of Rochester Med. Ctr., Rochester, NY. 244 Liver Histology After Hepatitis C Virus Treatment with Sustained Virologic Response: Should We Expect Inflammation? (1658) Brad D Barrows, Tram Tran, Maha Guindi. Cedars Sinai Medical Center, Los Angeles, CA. 245 Post-Transplant Plasma Cell Hepatitis in Primary Sclerosing Cholangitis: A Clinico-Pathologic Study (1689) Juan Putra, Thomas D Schiano, M Isabel Fiel. Icahn School of Medicine at Mount Sinai, New York, NY. PULMONARY PATHOLOGY 247 Tumor Budding and Single Cell Invasion Are Significant Prognostic Factors, Independent of Pathologic Stage, in Japanese Patients with Lung Squamous Cell Carcinoma (SQCC) (1936) Kyuichi Kadota, Kosuke Inoue, Emi Ibuki, Ryou Ishikawa, Yumi Miyai, Naomi Katsuki, Yoshio Kushida, Toru Matsunaga, Masaya Okuda, Hiroyasu Yokomise, Nobuhiro Kanaji, Shuji Bandoh, Reiji Haba. Kagawa University, Kagawa, Japan. 248 Tumor Metabolism in the Microenvironment of Squamous Cell Carcinoma of Lung (1952) Mehri Mollaee, Marina Domingo-Vidal, Diana Menezes, Tingting Zhan, Ubaldo Martinez-Outschoorn, Madalina Tuluc. Thomas Jefferson University, Philadelphia, PA. 249 Enrichment of Immune Cells in Tumor Microenvironment Correlates with Long-Term Survival in Small Cell Lung Cancer (1956) Prasuna Muppa, Simone BSP Terra, Aqsa Nasir, Nafiseh Janaki, Marie C Aubry, Eunhee S Yi, Aaron S Mansfield, Mariza de Andrade, Ping Yang, George Vasmatzis, Virginia P Van Keulen, Tobias Peikert, Farhad Kosari. Mayo Clinic, Rochester, MN. 250 CD44 Expression in Mucinous Adenocarcinomas of the Lung and the Potential for Targeted Therapy (1916) Liz Edmund, Shaolei Lu, Li Juan Wang. Brown University, Providence, RI. 251 The Role of IL-24 in Lung Adenocarcinoma (2002) Shigeaki Umeda, Koji Okudela, Yoko Tateishi, Mai Matsumura, Kenichi Ohashi. Yokohama City University, Yokohama, Kanagawa, Japan. 252 HMGA2 Immunostaining Is a Straightforward Technique Which Helps to Distinguish Pulmonary Fat- Forming Lesions from Normal Adipose Tissue in Small Biopsies (1972) Nicolas Piton, Émilie Angot, Florent Marguet, Jean- Christophe Sabourin. Rouen University Hospital, Rouen, France. 253 Nodular Fibrinous Organizing Pneumonia with Atypical Septal Lymphocytes: An Under-Recognized Presentation of Lymphoma (1921) Arash Eslami, Kirk Jones. University of California San Francisco, San Francisco, CA. 246 A Study of Random versus Directed Lymph Node Biopsies in Lung Cancer Staging (1918) Siba El Hussein, Roy Williams, John Alexis. Mount SInai Medical Center, Miami Beach, FL. 230

291 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Hybrid-Capture Based Comprehensive Genomic Profiling of Lung Adenocarcinoma Identifies Patients Who May Benefit from Targeted Therapies as Well as Immunotherapies Using Tumor Mutational Burden (TMB), a New Predictive Biomarker of Response to Immune Checkpoint Inhibitors (1924) Garrett Frampton, Anika Gupta, Caitlin Connelly, David Fabrizio, Alexa Schrock, Laurie M Gay, Shakti Ramkissoon, Julia A Elvin, Jo-Anne Vergilio, Siraj M Ali, Vincent Miller, Philip Stephens, Jeffrey Ross, James Suh. Foundation Medicine, Inc., Cambridge, MA. 255 Correlation of Thyroid Transcription Factor (TTF-1) Immunostaining Status with Somatic Mutations in Lung Adenocarcinomas Detected by Targeted Next Generation Sequencing (NGS) (1976) Rongqin Ren, Nabil Ashraf, Catherine I Dumur, Jorge A Almenara, Michael O Idowu, Adele O Kraft, Celeste N Powers. Virginia Commonwealth University Health System, Richmond, VA. 256 The Clincopathological and Mutation Analysis of Pulmonary Mucin-Producing Adenocarcinoma (1990) Guoguo Shang, Yan Jin, Yuan Li. Fudan University Shanghai Cancer Center, Shanghai, China. 257 ALK Gene Rearranged Pulmonary Adenocarcinomas: Demographics, Clinicopathologic, and Treatment Profile in a Cohort of South East Asian Patients (1991) Shivani Sharma, Lata Kini, Samriti Arora, Aurobinda Samal, Shipra Garg, Arbind Singh, Mohit Kumar, Beklaswar Salona, Sankar Mohan, Ajay Pandita, Rahul Katara, Sambit K Mohanty. CORE Diagnostics, Gurgaon, Haryana, India. 258 Circulating Tumor Cell Detection via a Novel FISH Assay Prior to Lung Biopsy Enables Accurate Prediction of Pulmonary Malignancy (1996) Amber L Smith, Tanweer M Zaidi, Namita Shanbhag, Duy Truong, Sara Shkedy, Brenda L Namer, Joshua D Kuban, Ruth L Katz. MD Anderson Cancer Center, Houston, TX. 259 PD-L1 Expression Is Associated with KRAS and BRAF Mutations in Primary Lung Adenocarcinomas (1951) Christine Minerowicz, Caitlyn Miller, Sanja Dacic. University of Pittsburgh Medical Center Presbyterian, Pittsburgh, PA. 260 PDL-1 Expression in Lung Adenocarcinoma Evaluated by Immunohistochemistry and RNA ISH Assay (1964) Claudia Ormenisan Gherasim, Diane Lawson, Wanhong Jiang, Cynthia Cohen. Emory University, Atlanta, GA. 261 Programmed Death Ligand-1 and Tumor Infiltrating Immune Cells in Non-Small Cell Lung Carcinoma, a Report from India (1933) Deepali Jain, Varsha Singh, Prabhat Malik, Sunil Kumar. All India Institute of Medical Sciences, New Delhi, Delhi, India. 262 Intratumoral Programmed Cell Death-Ligand 1 (PD- L1) and Intratumoral CD8 + T Cell Expression in Lung Cancer (1935) Yasuto Jin, Osamu Matsubara, Kazuki Yamanaka, Eugene Mark. Hiratsuka Kyosai Hospital, Hiratsuka, Japan; Massachusetts General Hospital and Harvard Medical School, Boston, MA. 263 Increased PD-L1 and FOXP3 Expression Correlates to Worse Overall Survival and Nodal Disease in Patients with Lung Adenocarcinoma (1974) Kate Poropatich, Rishi Raj, Kalliopi P Siziopikou, Kirtee Raparia. Northwestern University, Chicago, IL. 264 Effects of Delay to Formalin Fixation on Immunohistochemical Expression of Diagnostic Antibodies in Mesothelioma (1969) John D Paulsen, Ryan Lau, Luis Chiriboga, Jonathan Melamed. New York University School of Medicine, New York, NY. 265 Pathologic Grading of Malignant Pleural Mesothelioma: A REAL Evidence-Based Proposal (1970) Giuseppe Pelosi, Anna Scattone, Andrea Marzullo, Angela De Palma, Alessandra Punzi, Federica Pezzuto, Elena Prisciandaro, Antonio Pennella, Anna Maria Catino, Gabriella Serio. University of Milan, Milan, Italy; Cancer Institute Giovanni Paolo II, Bari, Italy; University of Bari, Bari, Italy; University of Foggia, Foggia, Italy. 266 A Combination of MTAP and BAP1 Immunohistochemistry Is Useful for Differentiating Malignant and Benign Mesothelial Proliferatons in Tissue and Cytological Specimens (1942) Yoshiaki Kinoshita, Tomoyuki Hida, Makoto Hamasaki, Shinji Matsumoto, Tohru Tsujimura, Kunimitsu Kawahara, Kenzo Hiroshima, Yoshinao Oda, Kazuki Nabeshima. Fukuoka University School of Medicine and Hospital, Fukuoka, Japan; Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Osaka Prefectural Medical Center for Respiratory and Allergic Disease, Habikino, Osaka, Japan; Tokyo Women s Medical University Yachiyo Medical Cente, Yachio, Tokyo, Japan. 231

292 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall BAP1 Loss in Well-Differentiated Papillary Mesothelioma May Be Associated with Malignant Transformation (2008) Eunhee S Yi, Hee Eun Lee, Julian R Molina, Debra A Bell, Anja C Roden, William R Sukov. Mayo Clinic, Rochester, MN. 268 The Utility of E2F1 Protein Expression in Well- Differentiated Papillary Mesothelioma (1967) Kyung Park, Yuis Jimenez, Robert Taub, Gleneara Bates, Alain C Borczuk. Weill Cornell Medicine, New York, NY; Columbia University Med Ctr, New York, NY. 269 Transbronchial Lung Cryobiopsy in Idiopathic Pulmonary Fibrosis: Useful or Not? (1905) Adeline Chelliah, Hadeel Jawad, Nicola Ronan, Darren Dahly, Barry Plant, Michael Henry, Alberto Cavazza, Louise Burke. Cork University Hospital, Cork, Ireland; University College Cork, Cork, Ireland; S. Maria Nuova Hospital I.R.C.C.S., Reggio Emilia, Italy. 270 Frequency of Neuroendocrine Cell Proliferations in Lungs Explanted for Fibrotic Interstitial Lung Disease and Emphysema (1995) Susan Shyu, Jonathon E Heath, Allen P Burke. University of Maryland School of Medicine, Baltimore, MD. 271 The Role of Serum Amyloid A Staining of Granulomatous Tissues for the Diagnosis of Sarcoidosis (1919) Tony El Jabbour, Albert Huho, Llewellyn Foulke, Timothy Jennings, Efstratios Koutroumpakis, Siddhartha Dalvi, Haroon Chaudhry, Amit Chopra, Aakash Modi, Neha Rane, David J Prezant, Christine E Sheehan, Recai Yucel, Mehul Patel, Marc Judson. Albany Med Col, Albany, NY; Univercity of NM, Albuquerque, NM; Albert Einstein Col of Med, New York, NY; Fire Department of NYC, New York, NY; SUNY, Albany, NY. 272 Analysis of mtor Signaling Pathways in Lymphangioleiomyomatosis (1944) Ildiko Krencz, Anna Sebestyen, Judit Papay, Andras Jeney, Zoltan Hujber, Charles Burger, Cesar Keller, Andras Khoor. Semmelweis University, Budapest, Hungary; Hungarian Academy of Sciences, Budapest, Hungary; Mayo Clinic, Jacksonville, FL. 273 Evidence of Welding Exposure Is Readily Seen but Under-Reported in Lung Neoplastic Pathology Specimens (1985) Soma Sanyal, Judith A Crawford, Jerrold L Abraham. SUNY Upstate Medical University, Syracuse, NY. 274 Morphologic Findings in Native Lungs from Single Lung Transplant Recipients: An Autopsy Study of 11 Cases (2013) Xiaotun Zhang, Eunhee S Yi, John P Scott, Anja C Roden. Mayo Clinic, Rochester, MN. QUALITY ASSURANCE 275 Successful Implementation of Standard Dictation Templates for Routine Specimens in a County Hospital: Time and Cost Analysis (2049) Seema B Jabbar, Elena Lucas, Nichole Mora, Kyle Molberg, Stacy Hinson. Parkland Memorial Hospital and UTSW Medical Center, Dallas, TX. 276 A Web-Based Pathology Reporting System Enhances Efficiency and Promote Standardization in Routine Practice (2079) Zhenhong Qu, Mark A Micale, Ping L Zhang. William Beaumont Hospital -RO, Royal Oak, MI; William Beaumont Hospital -OR, Royal Oak, MI. 277 Introduction of an Asset-Tracking System: Flagging for Laboratory Improvement (2083) Christine J Salibay, Javier Sedillo, Manmeet Singh, Elizabeth Wiley, Tushar Patel. University of Illinois Hospital and Health Sciences System, Chicago, IL. 278 Intradepartmental Consultations in Surgical Pathology: Review of a Standardized Process and Factors Influencing Consultation Rates and Practices (2042) Emily Goebel, Helen Ettler, Joanna Walsh. Western University, London, ON, Canada. 279 The Value of Structured Prospective Intradepartmental Consultation (SPIDC) in a General Anatomic Pathology Practice (2090) John Srigley, Keiyan Sy, Janice Zeng. Trillium Health Partners, Mississauga, ON, Canada. 280 Pan-Canadian Quality Assurance Recommendations for Interpretive Pathology Development of a National Framework (2091) John Srigley, Natasha Camuso, Anubha Prashad, Diponkar Banerjee, Laurette Geldenhuys, Rosemary Henderson, Fergall Magee, C Meg McLachlin, Tarek Rahmeh, Stephen Raab, Esther Ravinsky, Bernard Têtu, Martin J Trotter, Robert Wolber. Canadian Partnership Against Cancer, Toronto, ON, Canada. 281 To Consult or Not to Consult? That Is the Question! Second Opinion in Surgical Kidney Specimens (2071) Rugvedita Parakh, Funda Vakar-Lopez, Lawrence True, Maria Tretiakova. University of Washington, Seattle, WA. 282 Common CPT Coding Corrections in an Academic Center (2036) Audrey Deeken-Draisey, Allison Ritchie, Timothy Carll, Guang-Yu Yang, Kruti P Maniar. Northwestern Medicine, Chicago, IL; Medical College of Wisconsin, Milwaukee, WI. 232

293 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Financial Impact of Non-Diagnosis Coding for Current Procedural Terminology Following ICD10 Implementation (2064) Clare McCormick-Baw, Arundhati Rao. Baylor Scott and White Memorial Hospital, Temple, TX. 284 High Sensitivity and Specificity Exists Between Frozen and Permanent Sections in Renal Transplant Biopsies (2027) Craig Cousineau, Ping L Zhang, Wei Li, Hassan D Kanaan. Beaumont Health, Royal Oak, MI. 285 Cost-Effective Triaging of Prostatectomy Specimens Using Light-Sheet Microscopy (2080) Nicholas P Reder, Adam K Glaser, Erin McCarty, Ye Chen, Jonathan TC Liu, Lawrence True. University of Washington Medical Center, Seattle, WA; University of Washington, Seattle, WA. 286 Simulated Partial Sampling of Radical Prostatectomy Specimens: A Prospective Study (2037) Jessica Dillon, Jason Pettus. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 287 Comparing UroVysion and Urine Cytology as a Quality Assurance Metric and to Evaluate the Relevance of the Paris System for Reporting Urinary Cytology in Our Institution (2081) Shira Ronen, Razvan Lapadat, Tamar Giorgadze, Jess F Peterson, Kenneth Iczkowski, Bryan Hunt. Medical College of Wisconsin, Milwaukee, WI. 288 Is Chemical Analysis of Recurrent Urinary Calculi Necessary? (2089) Justin Snow, Francesca Khani, Theresa Scognamiglio, Brian Robinson. New York Presbyterian/Weill Cornell Medicine, New York, NY. 289 Discordances in Evaluation of Melanocytic Lesions and Its Impact on Management: A Study of 1518 Cases (2018) Rami Al-Rohil, George Jour, Priyadharsini Nagarajan, Phyu P Aung, Michael T Tetzlaff, Jonathan L Curry, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto. Vanderbilt University, Nashville, TN; MD Anderson Cancer Center at Cooper, Camden, NJ; MD Anderson Cancer Center, Houston, TX. 290 Rapid FNA Diagnosis of Lymphadenopathy (2078) Jia Qin, Rosemary H Tambouret. Massachusetts General Hospital, Boston, MA. 291 Lymph Node Counting Practices by Trainees: A Pilot Study (2086) John P Sherbeck, Lili Zhao, Richard Lieberman. University of Michigan, Ann Arbor, MI. 292 Molecular Alterations and Pattern of Clinical Utilization of Targeted Next Generation Sequencing for Malignant Lymphoma at the University of Pennsylvania (2047) Jaleah Hawkins, Jennifer D Morrissette, Megan S Lim. University of Pennsylvania, Philadelphia, PA. 293 Defining True Cellularity in Age-Matched Marrows (2102) Jerry T Wong, Maryam D Ameri, David Cantu, Parwiz Siaghani, Joo Song, Dennis D Weisenburger, Young Kim. City of Hope National Medical Center, Duarte, CA. 294 Flow Cytometry Provides a Quantitative Benchmark for the Utility of Diagnostic Tests (2022) Meenakshi G Bansal, Richard Burack. University of Rochester Medical Center, Rochester, NY. 295 Improved Quality and of Platelet Count in Apheresis-Platelet Concentrate > Buffy Coat Platelet Concentrate & Platelet Rich Plasma-Platelet Concentrate, Assessed by Study of Quality Parameters in 119 Units of Platelet Concentrate. Why Is That? (2070) Felicia Nip, Mitul Modi. Gujarat Cancer & Research Institute, Ahmedabad, India; Michigan State University College of Human Medicine, East Lansing, MI. 296 Microcytic Anemia Work-Up: Utilization, Quality, and Evaluation of Serum Iron Studies (2052) Derek B Laskar, Alejandro Zuretti. SUNY Downstate Medical Center, Brooklyn, NY. 297 Evaluation of Body Fluids: Detection of Malignancy in Specimens Submitted for Cell Count and Differential in the Hematology Laboratory (2059) Remegio J Maglantay, Vickie L Cunningham, Michele T Goodwin, Margaret Feeney, Joan Keefe, Aliyah Sohani, Rosemary H Tambouret. Massachusetts General Hospital, Boston, MA. 298 Comparison of Two Methods for Cytologic Evaluation of Cerebrospinal Fluids (2060) Remegio J Maglantay, Jessica L Wang, Olga Pozdnyakova, Amy Ly. Massachusetts General Hospital, Boston, MA; Brigham and Women s Hospital, Boston, MA; Atrius Health, Needham, MA. 299 Institutional Experience with the Bethesda System for Reporting Thyroid Cytology (TBSRTC) and Performance Parameters of Cytopathologists (2085) Maryam Shahi, Sandhya Dasaraju, Matthew Root, Rupendra Shrestha, Lynn A Burmeister, Maria Evasovich, Khalid Amin. University of Minnesota, Minneapolis, MN. 300 The Addition of Cytospins from Needle Rinses Does Not Improve Specimen Adequacy on Thryoid Fine Needle Aspiration (2066) Daniel L Miller, Vivek Charu, Syed Z Ali, Christopher Vandenbussche. Johns Hopkins Hospital, Baltimore, MD; Johns Hopkins University School of Medicine, Baltimore, MD. 233

294 ABSTRACTS POSTER SESSION POSTER V SESSION Wednesday, March Day, Date, 08, :30 0:00 AM -- 12:00 0:00 PM Exhibit Hall Squamous Cell Carcinoma in Serous Effusions: Avoiding Pitfalls in This Rare Encounter (2055) Christopher D LePhong, Elizabeth W Hubbard, Laurentia Nodit. University of Tennessee, Knoxville, TN. 302 Antinuclear Antibody (ANA) 2016 Statistical Analysis. A Comparison of Laboratory Practice and Result Reporting Between the US and International Labs (2021) Richard J Baltaro, Gyorgy Abel, Christine Bashleben, Jonathan Genzen, Qing H Meng, David L Murray, Mu Shan, Mohammad Q Ansari. College of American Pathologists (CAP), Diagnostic Immunology Resource Committee, Northfield, IL; East Carolina University, Greenville, NC; Cleveland Clinic, Cleveland, OH; Lahey Hospital & Medical Center, Burlington, MA; University of Utah, Salt Lake City, UT; University of Texas MD Anderson Cancer Center, Houston, TX; Mayo Clinic, Rochester, MN. 303 Laboratory Developed Tests and Risk Stratification Proposals An Application (2067) Jeffrey S Mohlman, Ronald L Weiss, Jonathan Genzen, Robert L Schmidt. University of Utah, Salt Lake City, UT. 304 An Effective and Multidisciplinary Utilization Framework for Esoteric/ Referred Tests in Molecular Pathology (2043) Rohit Gulati, John L Carey, Dhananjay Chitale, Gaurav Sharma. Henry Ford Hospital, Detroit, MI. 305 Evaluating Clinical Utility of Actionable Genomic Alterations Identified by Comprehensive Genomic Profiling in Advanced or Recurrent Solid Tumors: A Tertiary Academic Hospital Review (2045) Danielle Harrell, Elham Nasri, Jong Kim. University of Florida, Gainesville, FL. 306 XIST as a Tool for Resolving Specimen Contamination Events (2028) Rory Crotty, Shilpa Prasad, Elena Brachtel, Vikram Deshpande. Massachusetts General Hospital, Boston, MA; Boston University, Boston, MA. 307 Optimization of MET FISH Reporting Criteria in Non- Small Cell Lung Cancer: MD Anderson Experience (2040) Lianghua Fang, Hui Chen, L Jeffrey Medeiros, Shimin Hu, Lin Pei, Raja Luthra, Rajesh R Singh, Mark J Routbort, David Hong, Xinyan Lu. The University of Texas MD Anderson Cancer Center, Houston, TX; Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China; Feinberg School of Medicine Northwestern University, Chicago, IL. 308 Should the Prenatal Cell-Free DNA Screening Test Replace the Quad Screen for Detection of Fetal Trisomies? (2017) Lubna A Alattia, Abhilasha Ghildyal, Menchu Ong, James G Traylor, Diana M Veillon. LSU Health Shreveport, Shreveport, LA. 309 Assessing Accuracy of HIV and HCV Testing Using Sigma-Metrics (2020) Burak Bahar, Nicolas Lopez-Hisijos, Jeanne E vonrentzell, Kamran Mirza. Yale-New Haven Hospital, New Haven, CT; Loyola University Medical Center, Maywood, IL. 234

295 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 BONE & SOFT TISSUE PATHOLOGY 1 FISH Is a Useful Adjunct to Support Diagnostic Accuracy of Core Needle Biopsies in Soft Tissue Lesions with Suspicion of Sarcoma: Comparison Study with Open Biopsies (67) Arjun Mehta, Wiliam W Tseng, Michael Pepper, Shefali Chopra. Keck Medical Center of USC, Los Angeles, CA. 2 Transducing-Like Enhancer of Split (TLE1): Promiscuous Staining Patterns in Soft Tissue and Other Neoplasms, a Diagnostic Pitfall (35) Samriti Arora, Anurag Sharma, Shivani Sharma, Vipin Kumar, Aurobinda Samal, Vijendra Bhandari, Arjun Singh, Santosh Pandey, Shipra Garg, Lata Kini, Sambit K Mohanty. CORE Diagnostics, Gurgaon, India. 3 Tumor Response of Neoadjuvant Intralesional Injection of Talimogene Laherparepvec with Concurrent Preoperative Radiation in Patients with Locally Advanced Soft Tissue Sarcomas Compared to Neoadjuvant Radiotherapy Alone: Histopathological Assessment (53) Omar Jaber, Varun Monga, Mohammed Milhem, Benjamin Miller, Munir R Tanas. University of Iowa, Iowa City, IA. 4 PAX8 Expression in Sarcomas: An Immunohistochemical Study (90) George A Tjionas, Andrew E Rosenberg, Daniel P Cassidy, Andre Pinto. University of Miami, Miami, FL. 5 Fusion Gene Detection in Sarcomas by the NanoString ncounter Fusion Gene Analysis Assay (40) Kenneth Chang, Angela Goytain, Cheng-Han Lee, Torsten Nielsen, Tony Ng. KK Women s and Children s Hospital, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore; University of British Columbia, Vancouver, BC, Canada; Vancouver General Hospital, Vancouver, BC, Canada. 6 Prognostic Significance of TAZ/YAP Activation and p53 Inactivation in Sarcomas (89) Jon Thomason, Stephanie Ivins, Benjamin Miller, Mohammed Milhem, Munir R Tanas. University of Iowa, Iowa City, IA. 7 PD-L1 Expression in Inflammatory Myofibroblastic Tumors (43) Tricia R Cottrell, Christopher D Gocke, Haiying Xu, Aleksandra Ogurtsova, Janis M Taube, Deborah Belchis. Johns Hopkins University School of Medicine, Baltimore, MD. 8 Radiation Therapy Related Down-Regulation of PD-L1 on High-Grade Poorly Differentiated Sarcomas Justify the Combined Radio-Immunotherapy (96) Dongguang Wei, Robert J Canter, Hong Qiu, Arta M Monjazeb, Mingyi Chen. UC, Davis, Sacromento, CA. 9 PD-L1 Expression in Sarcomas (61) Kemal Kosemehmetoglu, Ece Ozogul, Berrin Buyukeren Babaoglu, Gaye Y Güler Tezel, Gokhan M Gedikoglu. Hacettepe University, Ankara, Turkey. 10 Programmed Cell Death 1 (PD-1) Is Over Expressed in Giant Cell Tumor of the Bone and Adamantinoma (91) Alireza Torabi, Brad A Bryan, Clarissa N Amaya, Frank H Wians. Texas Tech University Health Science Center, El Paso, TX. 11 Novel NF1-TEK Fusion in Giant Cell Tumor of Bone (77) David J Pisapia, David C Wilkes, Patrick J McIntire, Kyung Park, Andrea Sboner, David S Rickman, Rohan Ramakrishna, Mark A Rubin, Juan Miguel Mosquera. Weill Cornell Medical College, New York, NY. 12 Absence of Histone 3.3 Mutations in Giant Cell Tumor of Soft Tissues (46) Alessandro Franchi, Alberto Righi, Marco Gambarotti, Piero Picci, Angelo P Dei Tos, Steven Billings, Lisa Simi, Irene Mancini. University of Florence, Florence, Italy; Rizzoli Institute, Bologna, Italy; Treviso Regional Hospital, Treviso, Italy; Cleveland Clinic, Cleveland, OH; University of Florence, Florence, Italy. 13 Clinicopathologic Features of Giant Cell Tumor of Bone (GCT) in Patients >55 Years of Age: A Study of 34 Patients (39) Cory Broehm, Carrie Inwards, Alyaa Al-Ibraheemi, Doris Wenger, Sarah Jenkins, Long Jin, Andre Oliveira, Riyam Zreik, Jodi Carter, Jennifer M Boland, Karen Fritchie. Mayo Clinic, Rochester, MN; Baylor Scott and White Health, Temple, TX. 14 Histological Features of Giant Cell Tumor of Bone (GCTB) Following Denosumab Treatment Mimicking Well-Differentiated Osteosarcoma (36) Andreia Barbieri, Mukul Divatia, Rex Marco, Gerald Buchert, Jae Ro, Alberto Ayala. Houston Methodist Hospital, Houston, TX. 15 Denosumab Induces the Disappearance of Osteoclastic Lineage Cells, but Failed to Eliminate the Tumor Cells of Giant Cell Tumor of Bone (58) Ikuma Kato, Mitsuko Furuya, Kosuke Matsuo, Reiko Tanaka, Kenichi Ohashi, Ichiro Aoki. Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; Yokohama City University Hospital, Yokohama, Kanagawa, Japan; Chiba University, Chiba, Japan. 16 Whole-Exome Analysis in Osteosarcoma: A Translational Research to Identify a Personalized Therapy (66) Massimiliano Mancini, Caterina Chiappetta, Chiara Puggioni, Vincenzo Petrozza, Chiara Mazzanti, Francesca Lessi, Paolo Aretini, Generoso Bevilacqua, Carlo Della Rocca, Claudio Di Cristofano. Sapienza University of Rome, Latina, Italy; Pisa Science Foundation, Pisa, Italy. 235

296 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 17 Craniofacial Osteosarcoma: A Clinicopathological Study (65) Chuanyong Lu, Ivana Petrovic, Lu Wang, Wen Chen, Jatin Shah, Meera Hameed. Memorial Sloan Kettering Cancer, New York, NY; Washington DC VA Medical Center, Washington, DC. 18 Upstream Regulation of Wnt Pathway in Osteosarcoma Implications for Diagnosis and Treatment (63) Victor K Lee, Kenon S Chua, Huey J Lim, Cheri Chan. NUHS, Singapore, Singapore; Singapore General Hospital, Singapore, Singapore. 19 Pseudomyogenic Hemangioendothelioma of Bone and Soft Tissue A Clinicopathologic, Immunohistochemical and Fluorescence In Situ Hybridization Study of 7 Cases (78) Dinesh Pradhan, Richard L McGough, Karen E Schoedel, Sarangarajan Ranganathan, Uma NM Rao. University of Pittsburgh Medical Center, Pittsburgh, PA. 26 Ossifying Fibromyxoid Tumor: Report of a Case Characterized by a Novel HCFC1-PHF1 Fusion Product (86) Margaret K Stevenson, David Swanson, Andrew Wong, George Charames, Rita A Kandel, Brendan C Dickson. Mount Sinai Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; Lunenfeld- Tanenbaum Research Institute, Toronto, ON, Canada. 27 EWSR1 Fusions with CREB Family Transcription Factors Define a Novel Myxoid Mesenchymal Tumor with Predilection for Intracranial Location (55) Yu-Chien Kao, Yun-Shao Sung, Lei Zhang, Sumathi Vaiyapuri, Marc Rosenblum, Cristina R Antonescu. Memorial Sloan Kettering Cancer Ctr, New York, NY; Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; The Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, United Kingdom. BREAST PATHOLOGY 20 Primary Pseudomyogenic Hemangioendithelioma of Bone: A Monoinstitutional Retrospective Clinicopathologic and Molecular Analysis of 21 Cases (83) Marta Sbaraglia, Alberto Righi, Marco Gambarotti, Daniel Vanel, Angelo P Dei Tos, Piero Picci. Rizzoli Orthopaedic Institute, Bologna, Italy; Treviso Regional Hospital, Treviso, Italy. 21 Craniofacial Chondromyxoid Fibromas: Clinicopathologic Analysis of 23 Cases (68) David M Meredith, Christopher DM Fletcher, Vickie Y Jo. Brigham and Women s Hospital, Boston, MA. 22 Immune Microenvironment in Chordomas (94) Jen-Wei Tsai, Cheuk Hong Leung, Heather Lin, Davis R Ingram, Khalida Wani, Laurence D Rhines, Alexander J Lazar, Wei-Lien Wang. EDA Hospital, Kaohsiung, Taiwan; The University of Texas MD Anderson Cancer Center, Houston, TX. 23 Immunohistochemical Evaluation of Chromatin Regulatory Gene Surrogates in Chordoma (79) Daniel C Ramirez, Lu Wang, Khedoudja Nafa, Patrick Boland, Meera Hameed. Memorial Sloan Kettering Cancer Center, New York, NY. 24 Distribution of Inflammatory Cells Correlates with PDL- 1 Expression in Chordomas (48) Sergei R Guma, Chandra Sen, Matija Snuderl. New York University Medical Center, New York, NY. 25 Upregulation of USP6 Transcription Is Likely Driven by USP6 Gene Fusion in Aneurysmal Bone Cyst (54) Omar Jaber, Natalya Guseva, Aaron A Stence, Munir R Tanas, Aaron Bossler, Deqin Ma. University of Iowa, Iowa City, IA. 28 Oncotype DX Testing Does Not Benefit Patients with Low-Grade Breast Invasive Carcinoma (179) Yanjun Hou, Debra L Zynger, Zaibo Li. The Ohio State University Wexner Medical Center, Columbus, OH. 29 Histologic Subtypes of Breast Cancer Correlates with Recurrence Score When Divided by Risk Categories (133) Ali Fuat Cicek, Natalie Patel, Veerle Bossuyt, Serena Wong, Natalia Buza, Malini Harigopal. Gulhane School of Medicine, Ankara, Turkey; Yale School of Medicine, New Haven, CT. 30 Comparison of Oncotype DX and Magee Recurrence Scores in 60 Infiltrating Breast Carcinomas (240) Ugur Ozerdem, Fattaneh Tavassoli. Yale University School of Medicine, New Haven, CT. 31 Oncotype DX Recurrence Score of Special Subtypes of Breast Carcinoma (241) Ugur Ozerdem, Fattaneh Tavassoli. Yale University School of Medicine, New Haven, CT. 32 Ki-67 Score Is Not Predictive of Overall Survival, Disease-Free Survival or Metastasis in Estrogen Receptor Positive, Her2 Negative, Lymph Node Negative Breast Cancers (177) Matthew Hiskey, Pia Mendoza, Cameron Neely, Ceyda Sonmez, Chao Zhang, Yuan Liu, Momin T Siddiqui, Cynthia Cohen, Xiaoxian Li. Emory University, Atlanta, GA. 33 Breast Carcinoma with Recurrence Score Lower Than 18: Rate of Locoregional Recurrence in a Large Series with Clinical Follow-Up (286) Gulisa Turashvili, Edi Brogi, Monica Morrow, Alicja Wiszowaty, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y Wen. Memorial Sloan Kettering Cancer Center, New York, NY. 236

297 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 34 The 21-Gene Recurrence Score in Special Histologic Subtypes of Breast Cancer with Favorable Prognosis (285) Gulisa Turashvili, Edi Brogi, Monica Morrow, Alicja Wiszowaty, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y Wen. Memorial Sloan Kettering Cancer Center, New York, NY. 35 Can Features Evaluated in the Routine Pathologic Assessment of Invasive Breast Cancer Be Used to Predict the MammaPrint Clinical Risk Assessment Category? (145) Rosemarie Didonato, Susan Fineberg, Yumei Fu, Tianhua Guo. Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY. 36 The University of Rochester Modified Magee Algorithm (RUMMA) for Risk Stratification of Estrogen Receptor Positive Breast Cancer Patients; a Multi-Institutional Validation Study (287) Bradley M Turner, Mary Ann Sanders, Nyrie Soukiazian, Armen Soukiazian, Ping Tang, David Hicks. University of Rochester Medical Center, Rochester, NY; University of Louisville Health Science Center, Louisville, KY; University of Rochester, Rochester, NY. 37 Pathological Prognostic Factors in Estrogen Receptor Positive/Her2 Negative and Lymph Node Negative Breast Cancers (229) Pia Mendoza, Ceyda Sonmez, Chao Zhang, Cameron Neely, Yuan Liu, Xiaoxian Li. Emory University, Atlanta, GA; Winship Cancer Institute, Emory University, Atlanta, GA. 38 Low Progesterone Receptor Expression Is Associated with Distant Metastasis in Estrogen Receptor Positive/ HER2 Negative and Lymph Node Negative Breast Cancer (228) Pia Mendoza, Ceyda Sonmez, Cameron Neely, Chao Zhang, Yuan Liu, Xiaoxian Li. Emory University, Atlanta, GA; Winship Cancer Institute, Emory University, Atlanta, GA. 39 Validation of Prosigna (Breast Cancer Prognostication Assay) & Its Concordance with Oncotype DX & Mammoprint: Geisinger Health System s Experience (197) Nefize S Kip, Victoria Tutaeva, Jeffrey W Prichard, Rosemary Leeming, Taranjit K Arora, Victor G Vogel. Geisinger Health System, Danville, PA. 40 Value and Clinical Utility of Oncotype Dx for Patients with Recurrence Scores of 10 or Less: An Independent Value Study of Tumor Histopathology and Outcomes (140) David J Dabbs, Kate Serdy, Adam M Brufsky, Rohit Bhargava. Magee-Women s Hospital of UPMC, Pittsburgh, PA. 41 Breast Cancer Global Tumor Biomarkers: A Quality Assurance Study of Intratumor Heterogeneity (141) David J Dabbs, Agnieszka Onisko, Binara Assylbekova, Xin Li, Rohit Bhargava, Beth Z Clark. Magee-Womens Hospital of UPMC, Pittsburgh, PA. 42 ER, PR, and HER2/neu Testing in Breast Cancer: Quantifying the Value of Repeated Centralized Testing in Excision Specimens (174) Nosaibah Hariri, Andres A Roma, Farnaz Hasteh, Vighnesh Walavalkar, Oluwole Fadare. UCSD, San Diego, CA. 43 A Five-Plex IHC Assay for Detecting the Status of Hormone Receptor, Her2 and Basal-Like Subtype on FFPE Tissues Demonstrates High Concordance to Single IHC Tests in Invasive Breast Cancer (215) Haiping Liu, Sharmini Muralitharan. Thermo Fisher Scientific, Fremont, CA. 44 Leptin-Receptor Expression in Luminal-Type Breast Carcinoma Is Associated with Pathologic Features of Diffuse Risk but Not with Tumor Proliferation (275) Blerta Starova, Mahdi Rahimi, Marguerite Ennis, Ryan JO Dowling, Vuk Stambolic, Pamela J Goodwin, Martin C Chang. Mt Sinai Hosp and Univ of Toronto, Toronto, ON, Canada; Applied Statistician, Markham, ON, Canada; Princess Margaret Hospital, Toronto, ON, Canada. 45 Analytical and Clinical Performance of Monoclonal Antibodies 1E2, 1A6, and PgR636 in the Detection of Progesterone Receptor (PR) in Breast Cancer (122) Benjamin C Calhoun, Krista Catlow, Brian Mosteller, Daniel Warren, Kate Leith, J J Rowe, Christopher Lanigan, Karen Mrazeck, Julia Coach, Amy Hanlon- Newell, Raymond Jones. Cleveland Clinic, Cleveland, OH; Ventana Medical Systems, Inc., Tucson, AZ; Roche, Singapore, Singapore. 46 Progesterone Receptor Expression Is More Prognostic Than Estrogen Receptor and Ki-67 Expression in Invasive Lobular Carcinoma Compared to Invasive Ductal Carcinoma: A Multi-Institutional Study (191) Roula Katerji, Mary Ann Sanders, Ping Tang, David Hicks, Bradley M Turner. University of Rochester Medical Center, Rochester, NY; University of Louisville, Louisville, KY. 47 Improving Visual Quantification of Ki-67 Proliferative Index Using NDER, a Web-Based Training Platform (219) Thomas H Long, Nicholas P Reder, Daniel Glasser, Jonathan Henriksen, Mark R Kilgore. University of Washington Medical Center, Seattle, WA. 48 Correlation of Phosphohistone H3 Immunohistochemistry for Mitotic Count and Ki-67 Proliferation Index in 208 Cases of Breast Carcinoma (262) Farid Saei Hamedani, Elizabeth Wiley. University of Illinois at Chicago, Chicago, IL. 237

298 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 49 High Discordance of Separate Assessments of Nottingham Nuclear Pleomorphism Score Is a Strength; Empirical Proof of Why the Kappa Statistic Can Be Misleading (142) Leslie Dalton. South Austin Medical Center, Austin, TX. 57 Reporting the Size of Invasive Mammary Carcinoma in Ultrasound-Guided Core Needle Biopsy Is Crucial for Accurate Final Pathologic Staging (144) Stephanie N David, Mirna B Podoll, Melissa Straub, Mohamed M Desouki. Vanderbilt University Medical Center, Nashville, TN. 50 Nucleolar Prominence as the Only Morphological Attribute Used in Determining Nuclear Pleomorphism: Evaluation Based on Tissue Microarray Analysis (143) Leslie Dalton. South Austin Medical Center, Austin, TX. 51 Correlation Between Invasive Mammary Carcinoma Grade in Ultrasound-Guided Core Needle Biopsy and Subsequent Surgical Excision (251) Mirna B Podoll, Melissa Straub, Stephanie N David, Mohamed M Desouki. Vanderbilt University Medical Center, Nashville, TN. 52 Repeat Biomarker Testing (ER/PgR/HER2) in Grade 3 Breast Carcinoma Not Truly Necessary (178) Margaret Holmes, Jay Zeck, Mary Sidawy. MedStar Georgetown University Hospital, Washington, DC. 53 Estrogen Receptor Positive/Progesterone Receptor Negative/(ER+/PR-) Breast Cancer (BC) Has a Poor Response to Endocrine Therapy (ET) (169) Tao Guo, Tiansheng Shen, Jacob Britt, Omar Hameed, Gene P Siegal, Shi Wei. University of Alabama at Birmingham, Birmingham, AL. 54 Comparing the Gene Xpert Breast Cancer RUO mrna Assay with ER and HER2 Immunohistochemistry (IHC) for Rapid Biomarker Analysis (232) Marcellin Mugabe, Juliana Andrici, Ken Ho, Natalie Wu, Annnaliza Rizo, Edwin W Lai, Weidler Jodi, Wong Wendy, Michael Bates, Isabelle Izimukwiye, Jean Baptiste Muvunyi, Belson Rugwizangoga, Danny A Milner, Jane Brock. Brigham & Women s Hosptial, Boston, MA; Cepheid, Sunnyvale, CA; Kigali University Teaching Hospital, Kigali, Rwanda; King Faisal Hospital, Kigali, Rwanda; American Society of Clinical Pathology, Chicago, IL. 55 The Ki67 Index as a Prognostic Marker in Primary Hormone Receptor Positive/ Her2 Negative Luminal Breast Carcinoma (152) Saba El-Gendi, Iman Talaat, Ghada Abu-Sheasha. Faculty of Medicine, Alexandria, Egypt; Medical Research Institute, Alexandria, Egypt. CYTOPATHOLOGY 58 Do Liquid-Based Preparations of Thyroid Fine Needle Aspiration Specimens Perform Differently Than Conventional Preparations in the Diagnosis of Thyroid Lesions? Observations from the College of American Pathologists Nongynecologic Cytopathology Education (CAP NGC) Program (464) Z Laura Tabatabai, Daniel Kurtycz, Ritu Nayar, Rhona J Souers, Guliz Barkan, Paul Staats, Benjamin L Witt, Andrew H Fischer. University of California-San Francisco, San Francisco, CA; University of Wisconsin, Madison, WI; Northwestern University, Chicago, IL; College of American Pathologists, Northfield, IL; Loyola University, Maywood, IL; Univeristy of Maryland, Baltimore, MD; University of Utah, Salt Lake City, UT; University of Massachusetts, Worcester, MA. 59 Predicting Follicular Variant Papillary Thyroid Carcinoma: A 5-Year Retrospective Study at a Single Institution (430) Kirsten Pierce, Louis J Vaickus, Xiaoying Liu. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 60 Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Cytomorphologic and Molecular Correlates (447) Christopher Sebastiano, Bin Xu, Ronald Ghossein, Oscar Lin, Jean-Marc Cohen. Memorial Sloan Kettering Cancer Center, New York, NY; Sunnybrook Health Sciences Center, Toronto, Canada. 61 The Role of mirna Expression Analysis in Needle Aspirate Cytology of Indeterminate Thyroid Nodules (339) Anna Banizs, Joseph F Annunziata, Christina M Narick, Sara Jackson, Jan F Silverman, Sydney Finkelstein. Allegheny General Hospital, Pittsburgh, PA; Interpace Diagnostics, Pittsburgh, PA. 56 High Tumor Budding Count Is Associated with Poor Clinicopathological Features and Prognosis in Breast Carcinoma (274) Ceyda Sonmez, Suzanna J Logan, Bo Wei, Limin Peng, Uma Krishnamurti, Xiaoxian Li. Emory University, Atlanta, GA; Georgia State University, Atlanta, GA. 238

299 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 62 High-Throughput Genome Analysis and Molecular Characterization Helps Differential Diagnosis Between Follicular Adenomas and Carcinomas: Results in a Cohort of 146 Patients (473) Philippe Vielh, Zsofia Balogh, Catherine Richon, Guillaume Meurice, Bastien Job, Alexander Valent, Ludovic Lacroix, Virginie Marty, Nelly Motte, Philippe Dessen, Bernard Caillou, Abir Al Ghuzlan, Jean-Michel Bidart, Vladimir Lazar, Adel K El-Naggar, Martin Schlumberger. National Laboratory of Health, Dudelange, Luxembourg; Gustave Roussy Cancer Campus, Villejuif, France; MD Anderson Cancer Center, Houston, TX. 63 Fine Needle Aspiration Cytology of a Large Series of Anaplastic Thyroid Carcinoma (456) Amber L Smith, Beth S Edeiken-Monroe, Sinchita Roy- Chowdhuri, Savitri Krishnamurthy. MD Anderson Cancer Center, Houston, TX. 64 Utility of BRAF V600E Immunoperoxidase Stain in Cytology Preparations of Cell Block and Aspirate Smears in Thyroid Cancers (455) Amber L Smith, Michelle D Williams, Maria E Cabanillas, John Stewart, Wei-Lien Wang, Savitri Krishnamurthy, Sinchita Roy-Chowdhuri. MD Anderson Cancer Center, Houston, TX. 65 Prognostic Assessment of BRAF Mutational Testing in Preoperative Thyroid FNA Specimens (331) Rita Abi Raad, Susan Fernandez, Pei Hui, Kevin Schofield, Manju L Prasad, Guoping Cai, Adebowale Adeniran. Yale University School of Medicine, New Haven, CT. 66 Follow-Up of Nondiagnostic Thyroid Fine Needle Aspiration: An Institutional Review (330) Rita Abi Raad, Susan Fernandez, Kevin Schofield, Guoping Cai, Adebowale Adeniran. Yale University School of Medicine, New Haven, CT. 67 Digital Image-Assisted Quantitative Nuclear Analysis Improves Diagnostic Accuracy of Thyroid Fine-Needle Aspiration Cytology (398) Teklu Legesse, Krista Chain, Paul Staats. University of Maryland Medical Center, Baltimore, MD. 68 The Correlation of Afirma Gene Expression Classifier Results with Follow-Up Findings for Thyroid Fine Needle Aspiration Specimens (429) Yelena Piazza, Fan Lin, Haiyan Liu. Geisinger Medical Center, Danville, PA. 69 Preoperative Fine Needle Aspiration (FNA) Diagnosis of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Invasive Follicular Variant Papillary Thyroid Carcinoma (IFVPTC): The Experience in a Large Academic Center (454) Jamie Slade, John Sir Philip, Julia Samolczyk, Ritu Nayar, Haijun Zhou. Northwestern University, Chicago, IL. 70 A System for Automated Adequacy Assessment of Thyroid Fine Needle Aspiration Samples (446) Daniel Schmolze, Andrew Fischer. City of Hope, Duarte, CA; UMass Memorial Medical Center, Worcester, MA. 71 Evaluation of Noninvasive Follicular Neoplasms with Papillary-Like Nuclear Features, an Institutional Experience (477) Vivian Weiss, Carmen C Solorzano, Kim Ely, Mitra Mehrad. Vanderbilt University Medical Center, Nashville, TN. 72 Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFT-P): A Retrospective Institutional Analysis (388) Thomas Joyal, Darcy A Kerr, Jenna Lewis, Monica Garcia-Buitrago, Merce Jorda, Claudia Rojas, Carmen Gomez-Fernandez. Jackson Memorial Hospital, Miami, FL; University of Miami Hospital, Miami, FL. 73 Diagnostic Accuracy of Fine Needle Aspiration in Thyroid Nodules Arising in Patients with Graves Disease (374) Jen-Fan Hang, Mohammed T Lilo, Justin A Bishop, Syed Z Ali. The Johns Hopkins Hospital, Baltimore, MD; Taipei Veterans General Hospital, Taipei, Taiwan. 74 mir-375 Expression in the Cytological Algorithm Approach for Identification of Non-Invasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features (439) Esther Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Tommaso Bizzarro, Alfredo Pontecorvi, Celestino P Lombardi, Luigi M Larocca. Catholic University, Rome, Italy; Catholic University, Rome, Italy. 75 Impact of the Reclassification of Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (EFVPTC) to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on the Current Management Guidelines of the Bethesda System for Reporting Thyroid Cytopathology (397) Ryan P Lau, John D Paulsen, Tamar C Brandler, Aylin Simsir, Fang Zhou. New York University School of Medicine, New York, NY. 76 Diagnostic Implication of ThyroSeq Sequencing Assay on Thyroid Nodules with FNA Cytology Diagnosis of Bethesda III: Atypia of Undetermined Significance versus Follicular Lesion of Undetermined Significance (395) Israa Laklouk, Mahmoud L Soliman, Dhay Kamel, Huihong Xu, Sandra Cerda. Boston University Medical Center, Boston, MA. 239

300 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 77 Molecular Testing in Patients with Indeterminate Cytology of Thyroid Fine Needle Aspiration: A Single Medical Institute Experience (482) Zhongbo Yang, Kristen M Scheitler, Jennifer N Woods, Magda Esebua. University of Missouri, Columbia, MO. 85 Cytomorphologic and Molecular Evolution of EGFR- Mutated Lung Adenocarcinomas with Acquired Resistance to Tyrosine Kinase Inhibitors (361) Erika E Doxtader, Jennifer A Brainard, Charles D Sturgis, Vamsidhar Velcheti, Yaxia Zhang. Cleveland Clinic, Cleveland, OH. 78 Use of Novel Image Analysis to Characterize and Quantify Nuclear Features of Papillary Thyroid Carcinoma (364) George Eng, Rema A Rao, Ivan Chebib. Massachusetts General Hospital, Boston, MA; 2New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY. 79 Adequacy Criteria for Thyroid Fine Needle Aspirates Evaluated by ThinPrep Slides Only (474) Marina Vivero, Andrew Renshaw, Jeffrey F Krane. Brigham and Women s Hospital, Boston, MA; Baptist Hospital, Miami, FL. 80 Outcomes of Atypia of Undetermined Significance/ Follicular Lesion of Undetermined Significance in Thyroid Fine Needle Aspiration (487) Cynthia Zhao, Guillermo A Herrera, Elba A Turbat- Herrera. Louisiana State University Health Sciences Center, Shreveport, LA. 81 Ultrasonography-Guided Fine Needle Aspiration of Axillary Lymph Nodes for Identifying Metastatic Tumors and Monitoring Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer (472) Puneeta S Vasa, Abigail S Caudle, Wei Yang, Junsheng Ma, Roland Bassett, Henry M Kuerer, Savitri Krishnamurthy. The University of Texas MD Anderson Cancer Center, Houston, TX. 82 Performing Core Biopsy Alongside Fine Needle Aspiration of Metastatic Head and Neck Squamous Cell Carcinoma Improves Tissue Yield for Ancillary Studies without Increased Complications or Tissue Seeding (436) Lisa M Rooper, Mohammed T Lilo, William H Westra, Zahra Maleki. Johns Hopkins Hospital, Baltimore, MD. 83 Rhabdoid Glioblastoma: Cytologic Characteristics and Diagnostic Pitfalls (412) David C Marbury, Israh Akhtar, Kim R Geisinger, Maria Gonzalez, Dianne E Grunes, Stephen Raab, Ali G Saad. University of Mississippi Medical Center, Jackson, MS. 84 EBUS-TBNA in Metastatic NSCLC: Do Cytomorphological Features Correlate with Standardized Uptake Value of PET Scan? (391) Kianoosh Keyhanian, Harman S Sekhon. University of Ottawa, Ottawa, ON, Canada. 86 Detection of Mismatch Repair Protein Expression by Immunohistochemistry on Cytopathology Specimens: Implications for PD-1 Blockade Therapy (371) Adam J Gomez, Soo-Ryum Yang, Steven Long, Teri Longacre, Christina Kong. Stanford Health Care, Stanford, CA. 87 Implementation of Cell Block and Small Core Biopsy in Molecular Profiling of Metastatic Malignant Melanoma: A Comparison Study (403) Mohammed T Lilo, Neda Rezaee, Derek Allison, Emily M Adams, Zahra Maleki. Johns Hopkins Medical Institutions, Baltimore, MD. 88 Outcomes of Discordant and Equivocal Cytology and FISH in Biliary Brushing (415) Lily Mei, Ghazal Khan, Tatjana Antic, Ricardo R Lastra, Jeffrey Mueller, Ward Reeves, Irving Waxman, Uzma Siddiqui, Christopher Chapman, John Hart, Namrata Setia. The University of Chicago, Chicago, IL. 89 Performance of ALK and EGFR Testing on Cytological Specimens (466) Tatjana Terzic, Gilda dc Santos, Hyang-Mi Ko, Scott MacDonald, Dana Pabedinskas, Nazleen C Lobo, Scott L Boerner, Suzanne Kamel-Reid. Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. 90 Assessment of PD-L1 Status by Immunohistochemistry in Cytological Specimens of Non-Small Cell Lung Cancers: Correlation with the Results of Concurrent Surgical Specimens (340) Cameron Beech, David L Rimm, Veronique Neumeister, Guoping Cai. Yale University School of Medicine, New Haven, CT. 91 Panther Aptima HPV Assay Performance on FNA SurePath Samples of the Head and Neck: Validation and Early Experience at a Large Academic Center (372) Christopher C Griffith, Charles E Hill, Mihir Patel, Alessandra Schmitt, Melinda Lewis, Heather H Jones, Momin T Siddiqui. Emory University, Atlanta, GA. 92 The Prognostic Significance of a Few Cells: Anti- PD-L1 Testing in FNA Samples of Non-Small Cell Lung Adenocarcinoma (379) Johnathan Hollyfield, Avani Pendse, Leslie Dodd. The University of North Carolina, Chapel Hill, NC. 93 Fine Needle Aspiration of Lipoblastoma: Clinical, Cytological and Molecular Features (367) Joana Ferreira, Ricardo Fonseca, Maria M Lemos, Saudade Andre. IPO Lisboa Francisco Gentil, Lisboa, Portugal. 240

301 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall 1 94 NY-ESO-1 Expression Is Highly Sensitive and Specific in the Diagnosis of Myxoid Liposarcoma Using Cytology Cell Blocks (457) Stephen M Smith, Ming Jin, Paul E Wakely, O Hans Iwenofu. The Ohio State University, Columbus, OH. 101 Aberrant Expression of HMB-45 in Halo Nevi (532) Kristen N Ruby, Catherine L Liu, Ann E Perry, Shaofeng Yan. Dartmouth-Hitchcock Medical Center, Lebanon, NH; Bowdoin College, Brunswick, ME, United Arab Emirates. DERMATOPATHOLOGY 95 Expanded Traditional Melanoma FISH Testing versus CAP-QPCR to Identify High-Risk Melanocytic Lesions (506) Ruifeng Guo, Sindhuja Sominidi-Damodaran, Alexander Meves, Alina G Bridges. University of Florida, College of Medicine, Gainesville, FL; Mayo Clinic, Rochester, MN. 96 An Assessment of Copy Variations and Somatic Mutations in Advanced Melanomas by Clinical Next-Generation Sequencing (537) Alan E Siroy, Dawen Sui, JIng Ning, Rajyalakshmi Luthra, Keyur P Patel, Mark J Routbort, Russell R Broaddus, Priyadharsini Nagarajan, Phyu P Aung, Doina Ivan, Jonathan L Curry, Carlos A Torres-Cabala, Victor G Prieto, Michael A Davies, Alexander J Lazar, Michael T Tetzlaff. The University of Texas MD Anderson Cancer Center, Houston, TX. 97 Detection of Metastatic Melanoma Using Immunohistochemical Stains: How Many and Which Ones? (493) Mohammed A Alghamdi, Mostafa M Fraig, Zhenglong Wang, Ashley Mathew, Houda Alatassi. University of Louisville, Louisville, KY. 98 Correlation of ALK IHC with Wild-Type ALK and ALK ATI mrna Transcripts in Metastatic Melanoma (535) Kabeer Shah, Jadee Neff, Aaron S Mansfield, William R Sukov, Lori Erickson, Kevin Halling, Thomas J Flotte. Mayo Clinic, Rochester, MN. 99 SP174 Antibody Lacks Specificity for NRAS Q61R and Cross-Reacts with HRAS-and KRAS- Q61R Mutant Proteins in Malignant Melanoma (501) Anna Felisiak-Golabek, Shingo Inaguma, Artur Kowalik, Bartosz Wasag, Zengfeng Wang, Jerzy Lasota, Markku M Miettinen. National Cancer Institute, Bethesda, MD; Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; Holycross Cancer Center, Kielce, Swietokrzyskie, Poland; Medical University of Gdansk, Gdansk, Pomorskie, Poland. 100 Expression of PAX8 in Metastatic Melanoma (540) Evgeny Yakirevich, Yiang Hui, Kara A Lombardo, Diana Treaba. Rhode Island Hospital/Brown University, Providence, RI. 102 Diagnostic and Prognostic Value of Glucose Transporters in Melanocytic Lesions (531) Kristen N Ruby, Catherine L Liu, Zhongze Li, Shaofeng Yan. Dartmouth-Hitchcock Medical Center, Lebanon, NH; Bowdoin College, Brunswick, ME; Geisel School of Medicine at Dartmouth, Lebanon, NH. 103 In-Situ Protein Expression of Melanocyte Differentiation Antigen Tyrosinase-Related Protein-1 (TRP1) (514) Achim Jungbluth, Denise Frosina, Miriam Fayad, Travis J Hollmann, Klaus J Busam. Memorial Sloan Kettering Cancer Center, New York, NY. 104 Genetic and Epigenetic Alterations of Telomerase Reverse Transcriptase (TERT) in Metastatic Melanoma (495) Sumit Borah, Seungjae Lee, Raymond Barnhill, Reinhard Dummer, John M Kirkwood, Armita Bahrami,. St. Jude Children s Research Hospital, Memphis, TN; Institute Curie, Paris, France; University Hospital Zurich, Zurich, Switzerland; University of Pittsburgh Medical Center, Pittsburgh, PA. 105 SF3B1 R625 Mutations Occur in Non-Uveal Melanomas at a High Frequency (524) Navin Mahadevan, Frank C Kuo. Brigham and Women s Hospital, Boston, MA. 106 Non-V600E BRAF Mutations Are More Common in Cutaneous Melanomas of Head and Neck and Upper Extremity (492) Michelle Afkhami, Laleh Melstrom, Kim Nguyen, Alexis B Terrones, Raju Pillai, Dongqing Gu, Milhan Telatar, Patricia A Aoun. City of Hope Cancer Medical Center, Duarte, CA; Keck Graduate Institute, Claremont, CA; Meharry Medical College, Nashville, TN. 107 Antiviral Drugs as a Therapy Strategy in Advanced Stage of Malignant Melanoma? (509) Lisa Hillen, Anke M Haugg, Dorit Rennspiess, Axel zur Hausen, Véronique Winnepenninckx. Maastricht University Medical Center MUMC+, Maastricht, Netherlands; RWTH Aachen University Hospital, Aachen, Germany. 108 Can Psoriasis Have Eosinophils? (530) Gabriela Rosa, Anthony P Fernandez, Sarah Schneider, Steven Billings. Cleveland Clinic Foundation, Cleveland, OH. 241

302 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Expression of Markers for Pericytes and Myofibroblasts in Bleomycin (Bleo)-Induced Dermal Fibrosis: Potential Role of Neuropeptide Receptors in a Mouse Model for Scleroderma (SSc) (526) Elizabeth McKinnon, James Parra, Mohammad Ibrahim, Howard Levinson, Mary E Sunday. Duke University Medical Center, Durham, NC; Duke University, Durham, NC. 110 Delineation of Dermal Hyperneury as a New Entity. Report of Eight Cases (511) Eleni Ieremia, Vivek Mudaliar, Blanca Martin, Pablo Rodriguez, Philip LeBoit, Eduardo Calonje. Oxford University Hospitals Foundation Trust, Oxford, United Kingdom; University Hospitals of North Midlands, Stoke-on-Trent, United Kingdom; St John s Institute of Dermatology, London, United Kingdom; Hospital Universitario de Cabuenes, Asturias, Spain; University of California San Francisco, San Fransisco, CA. ENDOCRINE PATHOLOGY 111 The Utility of Digital Image Analysis on the Evaluation of Thyroid Needle Aspiration Cytology: A Pilot Study (603) Daryoush Saeed-Vafa, Pablo Valderrabano, Bryan McIver, Joseph Johnson, Yin Xiong, Anthony Magliocco, Barbara Centeno. Moffitt Cancer Center, Tampa, FL. 112 Prognostic Implication of Histological Features Associated with EHD2 Expression in Papillary Thyroid Carcinoma (584) Chan Kwon Jung, Yourha Kim, Min-Hee Kim, Sora Jeon, Ja Seong Bae. College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 113 Creating Personalized Mathematical Models of Gene Expression in Thyroid Carcinoma (608) Kaitlin Sundling, Ricardo V Lloyd. University of Wisconsin, Madison, WI. 114 Intratumoral Angiogenesis and Lymphangiogenesis, and Peritumoral Vascular Microenvironment in Thyroid Carcinomas (598) Zhengtong Pei, Lopa Modi, Virginia A LiVolsi, Paul Zhang. Hospital of the University of Pennsylvania, Philadelphia, PA; Barnabas Health, Livingston, NJ. 115 Cytologic Stratification of FLUS Improves Performance of Afirma (611) Ann E Walts, Cynthia Gudino, Wendy Sacks, Shikha Bose. Cedars-Sinai Medical Center, Los Angeles, CA. 116 Vasodilator-Stimulated Phosphoprotein (VASP) Immunoreactivity Is Associated with Lymphovascular Invasion and Lymph Node Metastasis of Papillary Thyroid Carcinoma: Role as a Potential Diagnostic Marker and Treatment Target (572) Betty Chen, Mufaddal Najmuddin, Xuemo Fan, Edward Bolesta, Ningling Kang, Jinping Lai. Saint Louis University School of Medicine, St. Louis, MO; Cedars-Sinai Medical Center, Los Angeles, CA; The Hormel Institue, Austin, MN. 117 Efficient Immunostaining Panel to Distinguish Poorly Differentiated/Undifferentiated Thyroid Carcinoma from Follicular and Papillary Carcinoma (577) Audrey Deeken-Draisey, Guang-Yu Yang, Borislav Alexiev. Northwestern Medicine, Chicago, IL. 118 Prognostic Roles of CD15 and Ki67 Immunohistochemistry in Medullary Thyroid Carcinoma (573) Ying-Hsia Chu, Heather Hardin, Ricardo V Lloyd. University of Wisconsin School of Medicine and Public Health, Madison, WI. 119 MicroRNAs mir-21 and mir-885 Are Associated with More Aggressive Behavior in Medullary Thyroid Carcinomas (574) Ying-Hsia Chu, Heather Hardin, Ricardo V Lloyd. University of Wisconsin School of Medicine and Public Health, Madison, WI. 120 MicroRNA Expression in Gastrointestinal Neuroendocrine Neoplasms (591) Rakesh Mandal, Ranran Zhang, Heather Hardin, Rebecca Baus, William Rehrauer, Ricardo V Lloyd. University of Wisconsin Hospital & Clinics, Madison, WI; University of Kansas Medical Center, Kansas City, KS. 121 Significant Predictive Biomarkers Expression Through Immunohistochemistry and Analysis of microrna in Gastroenteropancreatic Neuroendocrine Tumors (587) Rocio P López, Luis E Barrera-Herrera, María M Torres, Sandra Vega. Fundación Santa Fe de Bogotá, Bogotá, Colombia; Universidad de los Andes, Bogotá, Colombia. 122 Absence of PTEN Predicts Aggressive Behavior in Low Grade Neuroendocrine Tumors (583) Rajeswari Jayakumar, Sonali Lanjewar, Constantine A Axiotis. SUNY Downstate Medical Center, Brooklyn, NY. 123 Significance of Ki67 Proliferative Index in Carcinoid Tumors Involving Ovary (620) Xiaotun Zhang, Andrea Jones, Sarah Jenkins, Yajue Huang. Mayo Clinic, Rochester, MN. 242

303 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Novel Molecular Markers in Adrenocortical Tumors (596) Gabriella Nesi, Giada Poli, Massimo Mannelli, Michaela Luconi, Raffaella Santi. University of Florence, Florence, Italy. 133 Incidental Gallbladder Carcinoma Associated with Dysplasia and Acute Cholecystitis (645) D E Bosch, M M Yeh, R A Schmidt, P E Swanson, C D Truong. U of Washington, Seattle, WA. 125 Adrenal Gland Myelolipomas with Plasma Cell Neoplasms (589) David Levy, Chieh-Yu Lin, John P Higgins, Christian A Kunder, Chia-Sui Kao. Stanford University School of Medicine, Stanford, CA. 126 Biologic and Genetic Basis of a Histological Risk Assessment of Early Recurrence/Metastasis in Paragangliomas (578) Salvador Diaz-Cano, Nadia Talat, Alfredo Blanes, Klaus- Martin Schulte. King s College Hospital, London, United Kingdom; University of Malaga School of Medicine, Malaga, Spain. GASTROINTESTINAL PATHOLOGY 127 Raman Spectroscopic Characterization of Submucosal Fat Deposition: A Marker of Inflammatory Bowel Disease? (687) William Gibson, Isaac J Pence, Molly Cone, Kay Washington, Anita Mahadevan-Jansen. Vanderbilt University Medical Center, Nashville, TN; Vanderbilt University, Nashville, TN. 128 Profiling of Metastatic Colorectal Cancers Identifies Potential Responders to Targeted Therapy (841) Lei Zhang, Weiguo Liu, Wilfrido D Mojica. SUNY at the University at Buffalo, Buffalo, NY. 129 Complete Histopathologic Examination of Prophylactic Gastrectomy Specimens for CDH1 Germline Mutation: Is It Warranted in Routine Clinical Practice? (713) Dipti M Karamchandani, Zhaohai Yang. Penn State Hershey Medical Center, Hershey, PA. 130 Utility of NKX6.1 Staining in Gastrointestinal and Pancreatic Neuroendocrine Tumors (715) Juliana O Kissiedu, Brian Robinson, Shishir Maithel, Alyssa Krasinskas. Emory University Hospital, Syracuse, NY. 131 Polypoid Hyperplasia of the Colonic Mucosa (PH). A Pathologic and Molecular Reassessment of Endoscopically but Not Histologically Apparent Polyps (697) Erika Hissong, Helen Fernandes, Jose Jessurun. New York Presbyterian-Weill Cornell Medicine, New York, NY. 132 Calretinin Positivity in Poorly Differentiated Colorectal Carcinoma: A Diagnostic Pitfall (733) Sandy Liu, Deepthi Rao, Jaclyn Hechtman, Efsevia Vakiani, David S Klimstra, Jinru Shia. Memorial Sloan Kettering, NY, NY. 134 The Role of Prolactin Receptor in Colonic Adenocarcinoma and Its Precursors (741) Zaid Mahdi, Kerri Ann Latchminsing, Rafic Beydoun, Hayan Jaratli. Wayne State University, School of Medicine, Detroit, MI. 135 Differential Expression and Subcellular Localization of Tumor Suppressor Maspin in Adenocarcinoma of Gastroesophageal Junction and Its Precursors (740) Zaid Mahdi, Sijana Dzinic, Semir Vranic, Faruk Skenderi, Margarita Bernardo, Shijie Sheng, Rafic Beydoun. Wayne State University, School of Medicine, Detroit, MI; University Clinical Center of Sarajevo and School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegowina; Barbara Ann Karmanos Cancer Institute, Detroit, MI. 136 Equivocal CMV Staining by IHC: Frequency and Clinical Significance (630) Manju Ambelil, David Saulino, Atilla Ertan, Andrew W Dupont, Sushovan Guha, Mamoun Younes. University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX. 137 Genome-Wide Copy Aberrations Analysis Reveals Recurrent High Copy Gain of PTGER4 Gene in Colonic Mixed AdenoNeuroEndocrine Carcinoma and NeuroEndocrine Carcinoma (807) Namita Sinha, Daniel Gaston, Marissa Goudie, Makoto Matsioka, Weei-Yuarn Huang. Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada. 138 Co-Expression of HER Family Relates to Progression and Lymph Node Metastases in Human Colorectal Cancer (764) Hiroyuki Nozaka, Ai Igarashi, Miku Togashi, Sayaka Kurosawa, Yayoi Takahashi, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai. Hirosaki University, Hirosaki, Aomori, Japan; Iwate medical university, Morioka, Iwate, Japan. 139 Immunohistochemistry Based Molecular Classification of Gastric Cancer and Its Prognostic Significance (716) Jiwon Koh, Keun-Wook Lee, Soo Kyung Nam, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee. Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea. 140 Loss of YAP-1 Expression in Gastrointestinal Neuroendocrine Carcinomas (751) James A Miller, Tamara L Lotan. Johns Hopkins, Baltimore, MD. 243

304 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Unexpected Histopathological Findings in Appendectomy Specimens: An Institutional Experience (743) Abul Ala Syed Rifat Mannan, Malary Mani, Songyang Yuan, Huai-Bin Mabel Ko. Mount Sinai Hospital, New York, NY. 142 Prognostic Value of the Nestin Staining in Human Pancreatic Ductal Adenocarcinoma (640) Mohadese Behtaj, Wei Xin. University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH. 143 Novel Classification of Dysplasia in IBD (692) Noam Harpaz, John R Goldblum, Neil Shepherd, Robert H Riddell, Carlos A Rubio, Michael Vieth, Robert D Odze. Icahn School of Medicine at Mount Sinai, New York, NY; Cleveland Clinic, Cleveland, OH; Gloucestershire Cellular Pathology Laboratory, Gloucester, United Kingdom; Mount Sinai Hospital, Toronto, Canada; Karolinska Institutet, Stockholm, Sweden; Institute of Pathology, Bayreuth Clinic, Bayreuth, Germany; Brigham and Women s Hospital, Boston, MA. 144 A Study of Appendiceal Crypt Cell Adenocarcinoma (So-Called Goblet Cell Carcinoid and Its Related Adenocarcinoma) (762) Daisuke Nonaka, George Papaxoinis, Angela Lamarca, Paul Fulford, Juan Valle, Bipasha Chakrabarty. The Christie Hospital, Manchester, United Kingdom; The University of Manchester, Manchester, United Kingdom. 145 Patterns of Injury in Esophageal Candidiasis: Clinical, Endoscopic, and Pathologic Correlations (836) Dongmei Xing, Rhonda K Yantiss, Jose Jessurun. New York Presbyterian-Weill Cornell Medicine, New York, NY. 146 Alterations in Lamina Propria and Muscularis Mucosa in Ulcerative Colitis Are Associated with Prior Medication and Degree of Histologic Inflammatory Activity (829) Eric Willis, Rocio Lopez, Neha Agrawal, Florian Rieder, Ilyssa Gordon. Cleveland Clinic, Cleveland, OH. 147 Radio-Pathologic Correlation on CT Scan Findings for Appendiceal Tumors: Width of the Appendix the Most Important Clinching Factor (800) Deepika Savant, Cristina Sison, Sharon X Liang, Cathy Fan. Hofstra-Northwell Health School of Medicine, Lake Success, NY. 148 Upper Gastrointestinal Lesions in Peutz-Jeghers Syndrome (680) Ogechukwu Pearl Eze, Yaman Tarabishy, Kevin Waters, Maryam Pezhouh, Francis Giardiello, Lysandra Voltaggio, Elizabeth A Montgomery. Johns Hopkins Hospital, Baltimore, MD. 149 Mass Spectrometric Analysis of Gastrointestinal Amyloidomas (759) Megan O Nakashima, Claudiu V Cotta. Cleveland Clinic, Cleveland, OH. 150 Tissue Transglutaminase Immunohistochemistry: A Potentially Useful Adjunct Marker for a Tissue Diagnosis of Celiac Disease in Patients with Normal Duodenal Biopsies (704) Sarah Jamshed, Karen Dresser, Ninfa M Candela, Xiaofei Wang. University of Massachusetts Medical School, Worcester, MA. 151 Acute Esophageal Necrosis (Black Esophagus). Detailed Pathologic Description of Five Cases (669) Isabelle H Cui, Gerardo Aristi Urista, Rhonda K Yantiss, Erika Hissong, Steven Salvatore, Jose Jessurun. New York Presbyterian-Weill Cornell Medicine, New York, NY; Hospital General de México, Mexico City, Mexico. 152 Expression of Epithelial-Mesenchymal Transition Markers E-Cadherin and Vimentin in Esophageal Adenocarcinoma and Squamous Cell Carcinoma and Significant Association with New Proliferation Markers MCM4 and MCM7 (805) Meenal Sharma, Amy Lalonde, Dongfeng Tan, Tongtong Wu, Zhongren Zhou. URMC, Rochester, NY; MD Anderson, Houston, TX. 153 Site-Specific Molecular Alterations in Colorectal Carcinoma: KRAS Mutations Are More Frequently Identified in Cecal Adenocarcinoma Compared to Other Location Subsites (720) Michael Landau, Reetesh Pai. University of Pittsburgh Medical Center, Pittsburgh, PA. 154 Invasive Adenocarcinoma Arising from Low-Grade Appendiceal Mucinous Neoplasm: Clinicopathologic Features (788) Nemencio Ronquillo, Mark A Valasek. University of California San Diego, San Diego, CA. 155 Clinical Impact of Tumor Infiltrating Lymphocytes and Neutrophils in Advanced Gastric Cancer (770) Do Youn Park, Joo Yeun Kim, Young Keum Kim, So Jeong Lee. Pusan National University Hospital and Pusan National, Busan, Republic of Korea; Haeundae Paik Hospital, University of Inje College of Medicine, Busan, Republic of Korea. 156 Programmed Cell Death-Ligand 1 Expression in Microsatellite Instability-High Gastric Carcinomas (659) Junhun Cho, Young Hwan Chang, Hyunsik Bae, Kyoung-Mee Kim. Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea; Oregon Health & Science University, Portland, OR; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 244

305 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Diagnostic Value of Stage-Specific Expression of SMAD4 and TP53 in Barrett s-associated Neoplasia (730) Qingqing Liu, Huai-Bin Mabel Ko, Hongfa Zhu, Alexandros D Polydorides, Noam Harpaz. Ichan School of Medicine at Mount Sinai, New York, NY. 158 Molecular Lymph Node Staging in Rectal Carcinomas: Can It Be Performed? (625) Iban Aldecoa, Carla Montironi, Natalia Rakislova, Dulce Momblan, Josep Antoni Bombi, Francesc Balaguer, Antoni Castells, Antonio Lacy, Miriam Cuatrecasas. Hospital Clinic University of Barcelona, Barcelona, Spain. 159 Applications of Phosphohistone H3 and Ki-67 by Immunohistochemistry in Aiding Mitotic Counting in Gastrointestinal Stromal Tumors (GISTs) (677) Yanli Ding, Qing Zhao. Brigham and Women s Hospital, Boston, MA; Boston University Boston Medical Center, Boston, MA. 160 Histogical Characteristics Correlated with MSI Status in Colorectal Carcinomas in National Hospital Abuja, Nigeria (767) Friday Olah, Fatimah B Abdulkareem, Paul G Jibrin, Olusegun S Ojo, Said M Amin, Emmanuel E Oguntebi, Aisha N Adowanka, Henry Ewunonu. National Hospital, Abuja, FCT, Nigeria; Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeria; Obafemi Awolowo University Teaching Hospital, Ile Ife, Osun, Nigeria. 161 Somatic Variant Profiles of TP53 Mutant Colorectal Carcinomas (769) Andrea Olofson, John He, Jason D Peterson, Sophie J Deharvengt, Francine B de Abreu, Xiaoying Liu, Gregory J Tsongalis. Dartmouth-Hitchcock Medical Center, Lebanon, NH. 162 Incidental Splenic Findings in Pancreaticosplenic Resections for Primary Pancreatic Disorders (773) Nisha Patel, Andrew Evans, Paul G Rothberg, Raul S Gonzalez. University of Rochester Medical Center, Rochester, NY. 163 Frequency of Deficient Mismatch Repair (MMR) Proteins and HNPCC in Patients with Colorectal Carcinoma (CRC) Younger and Older Than or Equal to 70 Years (647) Azore-Dee Bradshaw, Margaret Cho, Gabriel Acosta Gonzalez, Richard A Hickman, Ruliang Xu. New York University Langone Medical Center, New York, NY. 164 Gastrointestinal Histopathologic Manifestations in Patients with Common Variable Immunodeficiency (CVID) (834) Xinyu Wu, Romulo Celli, Dhanpat Jain, Xuchen Zhang. Yale University, New Haven, CT. 165 Age Less Than Forty Is Predictive of Mismatch Protein Loss in Colorectal Tubulovillous Adenomas (622) Sohaib Abu-Farsakh, Danielle Marino, Arthur DeCross, Qi Yang, Loralee McMahon, Jennifer J Findeis-Hosey. University of Rochester Medical Center, Rochester, NY. 166 Clincopathologic Studies of PD-L1 Expression on Esophageal Adenocarcinoma and Squamous Cells Carcinoma (623) Sohaib Abu-Farsakh, Amy Lalonde, Tongtong Wu, Zhongren Zhou. University of Rochester, Rochester, NY. 167 Loss of Cellular Histone Modifications in Pancreatic Adenocarcinoma (725) Hongjie Li, Aaron E Harper, Danqi Chen, Chunyuan Jin, Steve Xie. Downstate Medical Center, Brooklyn, NY; New York University, Tuxedo Park, NY; Kings County Hospital, Brooklyn, NY. GENITOURINARY PATHOLOGY 168 3D Light-Sheet Microscopy Improves the Accuracy of Grading Prostate Cancer by Distinguishing Pattern 3 Glands from Poorly Formed Pattern 4 Glands (1014) Nicholas P Reder, Adam K Glaser, Erin McCarty, Ye Chen, Jonathan TC Liu, Lawrence True. University of Washington Medical Center, Seattle, WA; University of Washington, Seattle, WA. 169 Continuous versus Discontinuous Tumor Involvement: A Dilemma in the Quantitation on Prostate Biopsy (870) Caroline Bsirini, Alexandra Danakas, Hiroshi Miyamoto. University of Rochester, Rochester, NY. 170 Should Tertiary Grades Be Assessed on Radical Prostatectomy Specimens Using the WHO 2016 Grade Group System? (872) Allen P Burke, William R Gesztes, Huai-Ching Kuo, Inger L Rosner, Shiv K Srivastava, Isabell Sesterhenn. Joint Pathology Center, Silver Spring, MD; Center for Prostatic Disease Research, Rockville, MD. 171 Predicting High Risk Pathologic Features at Prostatectomy Using Multiparametric MRI (855) Heather S Barker, Brittaney E O Bryan, Houda Alatassi, Alberic Rogman, Albert Seow, Jamie Messer. University of Louisville, Louisville, KY. 172 Missing Cancer by Targeted Prostate Biopsy How Often Does It Matter? A Single Institution Experience (937) Ian Hughes, Vamsi Parimi, Joseph Yacoub, Gopal Gupta, Maria Picken. Loyola University Medical Center, Maywood, IL. 245

306 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Prognostic Value of Gleason Grade 4 and Its Architectural Patterns at Prostate Biopsy on Predicting Biochemical Recurrence Following Radical Prostatectomy (863) Athanase Billis, Leandro LL Freitas, Larissa BE Costa, Ruana M Rocha, Lucas QA Bastos, Gabriel LP Oliveira, Amanda P Herculiani, Karina S Araujo, Marcel A Asato, Daniele M Losada, Livia LA Azevedo, Gabriel VBS Tabosa, Bruna C Zaidan. School of Medical Sciences, State University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil. 174 The Discovery of Methylation and RNA Biomarkers of Prostate Cancer Upgrading After Surgery in Patients with Gleason Score 6 Biopsies (942) Nafiseh Janaki, Prasuna Muppa, Simone Terra, Aqsa Nasir, Hamed Rahi, George Vasmatzis, John C Cheville, Farhad Kosari. University Hospitals Cleveland Medical Center, Cleveland, OH; Mayo Clinic, Rochester, MN; University of Minnesota, Minneapolis, MN. 175 Prognostic Significance of Prostate Cancer with Seminal Vesicle Invasion on Radical Prostatectomy: A National Registry Study (896) Lars Egevad, Anna Kristiansen, Linda Drevin, Brett Delahunt, Hemamali Samaratunga, Pär Stattin. Karolinska Institutet, Stockholm, Sweden; Uppsala University Hospital, Uppsala, Sweden; Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Aquesta Pathology, Brisbane, Australia. 176 Influence of Chronic Inflammation on Bcl2 and PCNA Expression in Prostate Needle Biopsy Specimens (1016) Qinghu Ren, Michael Glover, Shardul Soni, Gregory T MacLennan, Sanjay Gupta. University Hospitals Cleveland Medical Center, Cleveland, OH; Case Western Reserve University, Cleveland, OH. 177 Clinicopathologic Correlation of Metastatic Prostatic Adenocarcinoma with Emphasizing Effects of Prognostic Grade, Extraprostatic Extension and Neoadjuvant/Adjuvant Therapy on the Onsets of Distant Metastasis (1082) Bo Xu, Ramayee Periakaruppan, Jinrong Cheng, Yingdong Feng. Roswell Park Cancer Institute, Buffalo, NY; State University of New York at Buffalo, Buffalo, NY. 178 Amphicrine Carcinoma: Expanding the Spectrum of Neuroendocrine Tumors of the Prostate (1008) Susan Prendeville, Issam Al-Bozom, Eva Comperat, Joan Sweet, Andrew J Evans, Mohammad Ben- Gasheer, Ozgur Mete, Theodorus van der Kwast, Michelle R Downes. University Health Network, Toronto, ON, Canada; Hamad Medical Corporation, Doha, Qatar; Hôpital Tenon, Paris, France; Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 179 Impact of the Case Pathologist on Prostate Needle Core Biopsy Diagnosis within a Single Institution (1045) Mit D Shah, Saranya Prathibha, Anil Parwani, Debra L Zynger. The Ohio State University Medical Center, Columbus, OH. 180 Ethnicity Background and the Predictive Power of the Composite Biopsy Grade Score on the Outcomes of Prostatic Adenocarcinoma (972) Xunda Luo, Priti Lal, Nirag Jhala, Jasvir S Khurana. Temple University Hospital, Philadelphia, PA; Hospital of the University of Pennsylvania, Philadelphia, PA. 181 Does Injection of 2-Aminobicyclo-(2,2,1)-Heptane-2- Carboxylic Acid (BCH) Affect Amino Acid Transporter Density in Prostate Cancer Xenografts? (998) Claudia Ormenisan-Gherasim, Funmilayo Tade, Oladunni O Akin-Akintayo, Birdal Bilir, Walter G Wiles, Guolan Lu, Baowei Fei, Carlos S Moreno, Mark M Goodman, David M Schuster, Adeboye O Osunkoya. Emory University, Atlanta, GA; Emory University School of Medicine, Atlanta, GA. 182 MYC Drives Overexpression of Telomerase RNA (htr/ TERC) in Prostate Cancer (853) Javier A Baena Del Valle, Qizhi Zheng, David Esopi, Michael Rubenstein, Gretchen K Hubbard, Maria C Moncaliano, Andrew Hruszkewycz, Ajay Vaghasia, Srinivasan Yegnasubramanian, Sarah J Wheelan, Alan Meeker, Christopher M Heaphy, Angelo M De Marzo. The Johns Hopkins University School of Medicine, Baltimore, MD; Fundacion Santa Fe De Bogota, Bogota DC, Colombia; University of Maryland, Baltimore County, Baltimore, MD; National Cancer Institute, Bethesda, MD. 183 Comparison of PELP1 and GATA3 Protein Expression in Urothelial Carcinoma in Cystoprostatectomy Specimens (926) Lakshmi Harinath, Shweta Patel, Edward Lynch, William Thompson, Jan F Silverman. Allegheny General Hospital, Pittsburgh, PA. 184 Frequency of Subtypes in High Grade Urothelial Carcinoma of the Urinary Bladder (1002) Delia Perez Montiel, Carolina Silva Morera, Anna Scavuzzo, Julia Mendoza Perez, Miguel Angel Jimenez, Lourdes Pena, Guadalupe Moncada, David Cantu de Leon. Instituto Nacional de Cancerologia, Mexico City, Mexico. 185 Loss of LINE-1 Expression Could Help to Differentiate High Grade Malignancies of the Urothelium from Low Grade and Benign Conditions (1034) Angela Sanguino Ramirez, Thu Tran, Alex Forrest-Hay, Kathleen Cieply, Sheldon Bastacky, Rajiv Dhir. University of Pittsburgh, Pittsburgh, PA; Thermo Fisher Scientific, Santa Clara, CA. 246

307 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Prediction of Tumor Focality in the Upper Urinary Tract Based on Concurrent or History of Cystectomy or Biopsy Proven Bladder Cancer (907) Shiraz Fidai, Tatjana Antic. The University of Chicago, Chicago, IL. 194 Morphologic and Clinical Features of So-Called Oncocytic Papillary Renal Cell Carcinoma (950) Shivani Kandukuri, Thing Rinda Soong, Paola Dal Cin, Michelle S Hirsch. Brigham And Women s Hospital, Boston, MA. 187 Argininosuccinate Synthetase Loss in High Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20 (921) Sounak Gupta, Divya Sahu, Prabin Thapa, John C Cheville, Donna Hansel. UCSD, La Jolla, CA; Mayo Clinic, Rochester, MN. 188 Immunohistochemical Analysis of the Unfolded Protein Response in Urothelial Carcinoma (1051) James Solomon, Mariah Z Leivo, Jeffrey J Rodvold, Maurizio Zanetti, Jonathan H Lin, Donna Hansel. Univ of California, San Diego, San Diego, CA. 189 Expression of OCT4 in Small Cell Carcinoma of the Urinary Bladder (1030) Ronda Sanders, Enrique Rodriguez-Zarco, Paula S Espinal, Andre Pinto, Ana Vallejo-Benítez, Merce Jorda. University of Miami Miller School of Medicine, Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center, Miami, FL; Virgen de la Macarena Hospital, Seville, Spain. 190 DPC4 Expression Status in Upper Tract Urothelial Carcinoma (UTUC) (1059) Aline C Tregnago, Maria Del Carmen Rodriguez Pena, James A Miller, Isabela W Cunha, Stephania M Bezerra, Hirofumi Nonogaki, Rajni Sharma, Kazutoshi Fujita, George J Netto. Johns Hopkins University, Baltimore, MD; Osaka University, Osaka, Japan; AC Camargo Cancer Center, Sao Paulo, Brazil. 191 Nuclear Factor (NF)-κB Immunohistochemistry in Bladder Cancer as a Predictor of Tumor Progression as Well as Chemosensitivity (941) Satoshi Inoue, Eiji Kashiwagi, Hiroki Ide, Alexander Baras, George J Netto, Hiroshi Miyamoto. University of Rochester, Rochester, NY; Johns Hopkins University, Baltimore, MD. 192 GLUT1 Expression Is Related to Tumor Recurrence and Survival in Renal Cell Carcinoma Clear Cell Type (959) Katia RM Leite, Paulo A Carvalho, Celine M Pinheiro, Sabrina T Reis, Miguel Srougi, William C Nahas. University of Sao Paulo Medical School, Sao Paulo, Brazil; Sao Paulo State Cancer Institute ICESP, Sao Paulo, Brazil; Cancer Hospital of Barretos, Barretos, Sao Paulo, Brazil. 193 Renal Cell Carcinoma with Hemangioblastoma-Like Features: A Clinicopathologic Study of 4 Cases (1088) Ming Zhao, Xiaoming Qiu, Minghua Fan, Lianghong Teng, Dengfeng Cao. Zhejiang People s Hospital, Hangzhou, China; Fujian Longyan First Hospital, Longyan, China; Beijing Xuanwu Hospital, Beijing, China; Washington University School of Medicine, Saint Louis, MO. 195 Analytical and Interpretative Phases of Molecular Diagnostics of MiTF Family Translocation Renal Cell Carcinoma (869) Matteo Brunelli, Serena Pedron, Anna Caliò, Stefano Gobbo, Guido Martignoni. University of Verona, Verona, Italy. 196 Linking Histological Phenotype to Molecular Changes in Sunitinib Resistant Clear Cell Renal Cell Carcinoma (963) Zsuzsanna Lichner, Rola Saleeb, Henriett Butz, Roy Nofech-Mozes, Sara Riad, Kapus Andras, George M Yousef. St Michael s Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. 197 Hilar Fat Infiltration: An Independent Prognostic Factor in Metastatic Clear Cell Renal Cell Carcinoma with Sunitinib First-Line Treatment (947) Solene-Florence Kammerer-Jacquet, Angelique Brunot, Karim Benasalah, Boris Campillo-Gimenez, Mathilde Lefort, Sahar Bayat, Alain Ravaud, Frantz Dupuis, Mokrane Yacoub, Gregory Verhoest, Romain Mathieu, Benoit Peyronnet, Alexandra Lespagnol, Jean Mosser, Julien Edeline, Brigitte Laguerre, Jean-Christophe Bernhard, Nathalie Rioux-Leclercq. Hospital University, Rennes, France; Centre Eugene Marquis, Rennes, France; EHESP, Rennes, France; Hospital Universty, Bordeaux, France. 198 Lymphovascular Invasion in Seminoma Revisited A Potential Overstaging Pitfall (1035) Aylin Sar, Kiril Trpkov, Asli Yilmaz. University of Calgary, Calgary, AB, Canada. 199 Anaplastic Features Do Not Influence Expression of PD-1 and PDL-1 in Testicular Seminomas (917) Zakaria Grada, Siraj M El Jamal, Yiang Hui, Nour Almardini, Kara A Lombardo, Ali Amin. Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI; University of Mississippi Medical Center, Jackson, MS. 200 Composite Pheochromocytoma/Paraganglioma- Ganglioneuroma: A Clinicopathologic Study of 8 Cases with Analysis of Succinate Dehydrogenase (900) Lori Erickson, Sounak Gupta, Manli Jiang, Jorge Torres-Mora, Michael Rivera, Jun Zhang. Mayo Clinic, Rochester, MN. 201 The Impact of Routine Frozen Section Analysis During Penectomy on Surgical Margin Status and Long-Term Oncologic Outcomes (887) Alexandra Danakas, Caroline Bsirini, Hiroshi Miyamoto. University of Rochester, Rochester, NY. 247

308 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Histopathologic and Immunohistochemical Findings in Orchiectomy Specimens of Patients Undergoing Gender Reassignment Surgery (977) Andres Matoso, Li J Wang, Shamlal Mangray, Kara A Lombardo, Murray B Resnick, Evgeny Yakirevich. Brown University, Providence, RI. 203 Testis Specific Y-Like Gene-5(Tspyl-5) a Potential Biomarker to Stratify Tumor Phenotype in Prostate Cancer Patients (901) Magda Esebua, Senthil R Kumar, Lester Layfield. University of Missouri, Columbia, MO. GYNECOLOGIC AND OBSTETRIC PATHOLOGY 204 Differentiated Vulvar Intraepithelial Neoplasia Associated with Intraepithelial Neoplastic Spread and with Usual Vulvar Intraepithelial Neoplasia (1202) Kien T Mai. University of Ottawa, Ottawa, ON, Canada. 205 Accentuated p53 Staining in Usual Type Vulvar Dysplasia, a Potential Diagnostic Pitfall (1169) Matthew Jeffreys, Susanne Jeffus, Charles M Quick. UAMS, Little Rock, AR HPV-Independent Vulvar Squamous Cell Carcinoma Has a Worse Prognosis Than HPV-Associated Disease: A Retrospective Cohort Study (1177) Anthony N Karnezis, Samuel Leung, Angela S Cheng, Dianne Miller, Aline Talhouk, C Blake Gilks, Jessica N McAlpine. University of British Columbia, Vancouver, BC, Canada. 207 Squamous Cell Carcinoma and Precancerous Lesions of the Vulva; Histopathological and Immunohistochemical Analysis of 37 Cases (1239) Junyoung Shin, Eun Na Kim, Kyu-Rae Kim. University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. 208 Epidermal Growth Factor Receptor (EGFR) Expression in Vulvar Squamous Cell Carcinoma (1194) Li Liang, Pamela Villalobos, Chi Hyun Lee, JIng Ning, Barbara Mino, Wei-Lien Wang, Jaime Rodriguez Canales, Amir A Jazaeri, Ignacio I Wistuba, Anna Yemelyanova. The University of Texas MD Anderson Cancer Center, Houston, TX. 209 PD-L1 Expression in Vulvar Squamous Cell Carcinoma: Immunohistochemical and RNA-Based In Situ Hybridization Analysis (1193) Li Liang, Pamela Villalobos, Chi Hyun Lee, JIng Ning, Barbara Mino, Wei-Lien Wang, Jaime Rodriguez Canales, Amir A Jazaeri, Ignacio I Wistuba, Anna Yemelyanova. The University of Texas MD Anderson Cancer Center, Houston, TX. 210 Prognostic Criteria in Vulvar and Vaginal Smooth Muscle Tumors: Evaluation of 68 Cases Comparing Multiple Classification Systems (1232) Sadia Sayeed, Deyin Xing, Paul Weisman, Darya Buehler, Laura Warmke, Cora Uram-Tuculescu, Cherise Cortese, J Kenneth Schoolmeester. Mayo Clinic, Rochester, MN; Johns Hopkins Hospital, Baltimore, MD; University of Wisconsin, Madison, WI; Virginia Commonwealth University Health System, Richmond, VA; Mayo Clinic, Jacksonville, FL. 211 Immunohistochemical Profiling of Mammary-Like Adenocarcinoma of the Vulva (1253) Basile Tessier-Cloutier, Torsten Nielsen, Karama Asleh- Aburaya, Varsha I Shah, W Glenn McCluggage, Anna Tinker, C Blake Gilks. Vancouver General Hospital, Vancouver, BC, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada; Singleton Hospital, Swansea, United Kingdom; Belfast Health and Social Care Trust, Belfast, United Kingdom. 212 PAX8, SOX10 and GATA3 Immunostains: Friend or Foe in the Diagnosis of Vulvar Paget Disease? (1104) Marina K Baine, Pei Hui, Natalia Buza. Yale University, Yale New Haven Hospital, New Haven, CT. 213 Mutation Analysis of Female Genital Tract Melanomas Uncovers Distinct Mutation Profiles (1230) Ozlen Saglam, Jamie Teer, Yonghong Zhang, Tania Mesa, Sean Yoder, Jane Messina. Moffitt Cancer Center, Tampa, FL. 214 Differentiated Squamous Intraepithelial Lesion (dsil)- Like Changes in the Epidermis Overlying Anogenital Melanocytic nevi. A Diagnostic Pitfall (1207) Kvetoslava Michalova, Dmitry V Kazakov, Michael Michal, Ladislav Hadravsky, Denisa Kacerovska, Marketa Miesbauerova, Boris Rychly, Michal Michal. Charles University, Medical Faculty and Charles University Hospital, Plzen, Czech Republic; Charles University, Third Medical Faculty and Charles University Hospital KralovskeVinohrady, Prague, Czech Republic; Cytopathos, Bratislava, Slovakia (Slovak Republic). 215 Liquid Based Cytology: Do Ancillary Techniques Enhance Detection of Epithelial Abnormalities? (1166) Nuzhat Husain, Sridhar Mishra, Namrata P Awasthi, Yashodhara Pradeep. Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, UP, India; King George s Medical University, Lucknow, UP, India. 248

309 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Determining the Clinical Features and Histopathological Types of Cervical Cancer in the Largest Tertiary Center in Ghana (1097) Patrick K Akakpo, Leonard Derkyi-Kwarteng, Simon Naporo, Frederick Hobenu. University of Cape Coast, School of Medical Sciences, Cape Coast, Central Region, Ghana; KORLE-BU Teaching Hospital, Accra, Greater Accra, Ghana; 37 Military Hospital, Accra, Greater Accra, Ghana. 217 Assessment of Clinical and Pathological Factors Contributing to Negative LEEP (1280) Youran Zou, Gloria Zhang, Charles V Biscotti, Jerome L Belinson, Bin Yang. Cleveland Clinic, Cleveland, OH. 218 Biopsies of Papillary Squamous Cell Carcinoma of the Uterine Cervix Frequently Underrepresent the Stromal Invasion Seen in the Excisional Specimens (1217) Atousa Ordobazari, Mehrdad Nadji, Marilyn Huang, Andre Pinto. University of Miami, Miami, FL. 219 Acantholytic Squamous Cell Carcinoma of the Uterine Cervix (1220) Delia Perez Montiel, Hugo Dominguez, Guadalupe Moncada, Lourdes Pena, David Cantu de Leon. Instituto Nacional de Cancerologia, Mexico City, Mexico. 220 Discrepancy Between Morphology, and p16 and Ki-67 Expression in Squamous Intraepithelial Lesions of the Lower Female Genital Tract (1136) Tsetan Dolkar, Anais Malpica, Preetha Ramalingam. MD Anderson Cancer Center, Houston, TX. 221 Focal Random-Appearing p16 Expression in the Cervix Signifies HPV Infection Near the Squamo-Columnar Junction (1243) T Rinda Soong, Jelena Mirkovic, Jan Brouwer, Natkrita Pohthipornthawat, Christopher P Crum, Michael Herfs. Brigham and Women s Hospital, Boston, MA; University of Liege, Liege, Belgium. 222 Using P16 Immunohistochemistry to Classify CIN 2 Lesions: Correlation of Ambiguous Staining Patterns with HPV Subtypes and Clinical Outcome (1198) Yuxin Liu, Mahfood Alqatari, Fei Ye, David Zhang, Tamara Kalir. Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, NY. 223 Utility of p16 vs. CK7 as a Predictive Biomarker in CIN 2 (1256) Brandon Umphress, Beatriz Sanchez, Ajit Paintal, Ritu Nayar, Kruti P Maniar. Northwestern University, Chicago, IL; IU Health Bloomington Hospital, Bloomington, IN. 224 Utility of CK7 and p16 in Classification of a Rare Variant of Squamous Intraepithelial Lesion of the Cervix (1118) Katelynn Campbell, Charles M Quick, Mayumi Nakagawa, Susanne Jeffus. University of Arkansas for Medical Sciences, Little Rock, AR. 225 CK7 Immunohistochemistry as a Predictor of CIN1 Progression: A Retrospective Study of Patients from the Quadrivalent HPV Vaccine Trials (1208) Anne Mills, Cherie Paquette, Tatjana Terzic, Philip E Castle, Mark H Stoler. University of Virginia, Charlottesville, VA; Albert Einstein College of Medicine, Bronx, NY. 226 Comparison of Automated HR-HPV E6/7 mrna ISH Against PCR, DNA ISH, and p16 IHC in 102 Samples of HPV-Related Neoplasia (1209) Anne Mills, Dawn C Dirks, James Bowden, Melinda D Poulter, Mark H Stoler. University of Virginia, Charlottesville, VA. 227 Low-Grade-Like High- Grade Squamous Intraepithelial Lesion of the Uterine Cervix: Histologic Characterization of Equivocal Dysplasias and Correlation with Human Papillomavirus Genotype (1203) Ramya Masand, Barrett Lawson, Derek Danner, Matthew Anderson, Ninad M Patil. Baylor College of Medicine, Houston, TX; Ben Taub General Hospital, Houston, TX. 228 Latent and Resolving HPV Infective Patterns in Cervical Squamous Epithelium Demonstrated by High Risk HPV mrna Chromogenic In Situ Hybridization (1200) Sophia Ma, Amy Ziober, Renee Frank, Kumarasen Cooper. Hospital of the University of Pennsylvania, Philadelphia, PA. 229 Cervical Cancer: A Retrospective Analysis of the Utility of HPV and Pap Testing for Women 60 Years and Older (1168) Lauren Isbell, Riyam Zreik, Parsa Hodjat, Kimberly Walker, Teresa Ponder, Arundhati Rao. Baylor Scott and White, Temple, TX. 230 mrna-based HPV Test Provides with More Accurate Genotyping Results for HPV16/18/45 Than DNA-Based HPV Test in Cervical Cancer Screening (1178) Jana Kaspirkova, Jana Cimická, Barbora Gomolčáková, Ondrej Ondič, Michal Michal. Biopticka Laborator, Plzen, Czech Republic; Sikluv Ustav Patologie, Plzen, Czech Republic. 231 Prevalence and Genotype Distribution of High Risk HPV Infection and Cervical Cytology of Women with CIN 2/3 in Southwest China (1170) Wei Jiang, Christopher C Griffith, Kaixuan Yang, Chengquan Zhao. West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Emory University, Atlanta, GA; Magee-Women s Hospital of UPMC, Pittsburgh, Pittsburgh, PA. 249

310 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Prior HC2 HPV Testing Results of 2546 Women with Histologically Diagnosed Cervical Intraepithelial Neoplasia 2/3 (1269) Tao Wu, Christopher Griffith, BaoWen Zheng, Xiangdong Ding, Zhengyu Zeng, Yaoming Liang, Chengquan Zhao. Guangzhou Kingmed Diagnostics, Guangzhou, China; Emory University, Atlanta, GA; University of Pittsburgh, Pittsburgh, PA. 233 Frequency of Rare and Multi Viral High-Risk HPV Subtype Infection in Cervical Squamous and Glandular Lesions in an Immigrant Dominant Middle Eastern Country: A PCR-Based Study (1223) M Ruhul Quddus, Alia Albawardi, Shamsa Al-Awar, Saeeda SH Almarzooqi. Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI; College of Medicine and Health Sciences, UAE University /Tawam Hospital, Al Ain, Abu Dhabi, United Arab Emirates; College of Medicine and Health Sciences, UAE University, Al Ain, Abu Dhabi, United Arab Emirates. 234 Comparison of the Frequency of Multi-Viral and Rare- Subtype(s) High-Risk HPV Infection in Glandular and Squamous Lesions of the Uterine Cervix in a Cervical Carcinoma Prevalent Country: A Retrospective PCR- Based Study (1099) Shabnam Akhter, Mohammed Kamal, C James Sung, W Dwayne Lawrence, M Ruhul Quddus. BSM Medical University, Shahbag, Dhaka, Bangladesh; Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI. 235 Adenocarcinoma of Cervix Is Surging: Is High-Risk HPV Subtype(s) Infection Pattern Changing in a Cervical Carcinoma Prevalent Developing Country? A Retrospective PCR-Based Study (1098) Shabnam Akhter, Mohammed Kamal, Ashim R Barua, C James Sung, W Dwayne Lawrence, M Ruhul Quddus. BSM Medical University, Dhaka, Bangladesh; Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI. 236 International Endocervical Criteria and Classification: Mucinous Endocervical Adenocarcinomas (MEA) (1245) Simona Stolnicu, Iulia Barsan, Lien Hoang, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Kay Park, Esther Oliva, Robert Soslow. University of Medicine and Pharmacy, Targu Mures, Romania; Vancouver General Hospital, Vancouver, Canada; Oncologic Institute, Iasi, Romania; Ospedale Sacro Coure Don Calabria, Negrar, Italy; Sheba Medical Center, Tel-Hashomer, Israel; Jikei University School of Medicine, Tokyo, Japan; Hospital de Oncologia, Mexico City, Mexico; MSKCC, New York, NY; Massachusetts General Hospital, Massachusetts, MA. 237 Application of a Pattern-Based Classification System of Endocervical Adenocarcinoma to Cervical Adenocarcinoma In Situ (1259) Koah Vierkoetter, Teresa C Porter, David M Shimizu. John A. Burns School of Medicine, University of Hawaii, Honolulu, HI. 238 Detection of Incidental Lobular Endocervical Glandular Hyperplasia in Hysterectomy Specimens Removed for Non-Cervical Lesions (1156) Sultan A Halimi, Daichi Maeda, Akiteru Goto. Akita University, Akita, Japan; Kabul Medical University, Kabul, Afghanistan. 239 Her2-Neu Expression in Gastric-Type Endocervical Adenocarcinomas (1180) Zanobia Khan, Orit Freedman, Joerg Schwock, Marcus Bernardini, Amit Oza, Kathy Han, Marjan Rouzbahman. University Health Network, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; Lakeridge Health Centre, Oshawa, ON, Canada. 240 Tissue-Based Immunohistochemical Biomarker Expression in Glandular Malignancies of the Cervix: A Systematic Review and Meta-Analysis (1191) Sandra Lee, Vikrant Sahasrabuddhe, Diana Mendoza- Cervantes, Sarah Rose, Rachel Zhao, Maire Duggan. South Health Campus, Calgary, AB, Canada; National Cancer Institute, Bethesda, MD; University of Calgary, Calgary, AB, Canada. HEMATOPATHOLOGY 241 Follicular Lymphoma Transforming to Double and Triple Hit Lymphoma; a Clinicopathologic, Morphologic and Cytogenetic Analysis (1525) Mehrnoosh Tashakori, Jessica Sanchez, Susan M Michalowski, Abner Louissaint, Kedar V Inamdar, Juan Gomez-Gelvez, John L Carey, Madhu P Menon. Henry Ford Health System, Detroit, MI; Massachusetts General Hospital, Boston, MA. 242 Relationship Between Cell of Origin, MYC Genetic Alterations, and MYC Expression in Aggressive B-Cell Lymphomas (1490) Aruna Rangan, Prasuna Muppa, Rhett P Ketterling, William R Macon, Ellen D McPhail. Mayo Clinic, Rochester, MN. 243 Clinicopathologic Features of High Grade B Cell Lymphomas with MYC and BCL6 Rearrangements: A Retrospective Review of Six Cases Including a Pediatric Case (1444) Francisco Llamas Gutierrez, Sarah Medane, Aline Moignet, Claire Lamaison, Elsa Poullot, Patrick Tas, Dan Chiforeanu, Cedric Pastoret, Thierry Lamy de la Chapelle, Marc-Antoine Belaud-Rotureau. University Hospital, Rennes, France; University Hospital, Creteil, France. 250

311 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Identifying MYC Rearrangements in Routine Clinical Practice by Screening with MYC Immunohistochemistry: A Single Institution Experience with 272 Consecutive Aggressive B-cell Lymphomas (1499) Hany Sakr, James R Cook. Cleveland Clinic, Cleveland, OH. 245 PD-L1 Expression in Plasmablastic Lymphoma with Clinical Correlation (1378) Jared Coberly, Arjun Gupta, George John, Harris Naina, Weina Chen. UT Southwestern Medical Center, Dallas, TX. 250 Evaluation of Lymphoproliferative Disorders in Patients with Systemic Lupus Erythematosus (1436) Sonali Lanjewar, Heba Saad, Kwabna Parker, Raavi Gupta, MA Haseeb. SUNY Downstate Medical Center, Brooklyn, NY. 251 Role of SMO in the Activation of PI3K/AKT Signaling in DLBCL (1532) Amineh Vaghefi, Nitin K Agarwal, Kranthi Kunkalla, Chae Hwa Kim, Youley Tjendra, Ralf Landgraf, Francisco Vega. University of Miami/Sylvester Comprehensive Cancer Center, Miami, FL. 246 The Germinal Center-Associated Marker LMO2 Is Uncommonly Expressed in Burkitt Lymphoma (1475) Natalia Papaleo, Ivonne Vazquez, Catalina Franco, Alexandra Valera, Fina Climent, Jose L Mate, Anna Mozos, Pilar Forcada, Elias Campo, Luis Colomo. Hospital del Mar, Barcelona, Spain; Hospital Clinic, Barcelona, Spain; Hospital de Bellvitge, Barcelona, Spain; Hospital Germans Trias i Pujol, Barcelona, Spain; Hospital de Sant Pau, Barcelona, Spain; Hospital Mutua de Terrassa, Barcelona, Spain. 247 Pediatric Burkitt s Lymphoma (BL) in Colombia Shows the Intermediate Characteristics Between the Endemic and Sporadic Clinical Variants (1401) Karen T Galvis Castro, Anne Senz, Lina E Jaramillo, Maria M Torres, Adriana Plata, Rafael E Andrade. Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia; Universidad Nacional de Colombia, Bogotá, Colombia; Fundación Hospital de la Misericordia, Bogotá, Colombia; Universidad de los Andes, Bogotá, Colombia; Universidad de los Andes, Facultad de Ciencias, Bogotá, Colombia. 248 LEF1 Expression Correlates with MYC and Non- Germinal Center B-cell Subtype in Diffuse Large B-Cell Lymphoma (1440) Li Li, Hui Li, Wayne Tam, Nikolay Popnikolov, J Steve Hou, Jing Zhou. Drexel University College of Medicine, Philadelphia, PA; Weill Cornell Medical College, New York, NY. 249 Cell of Origin (COO) of Diffuse Large B-Cell Lymphoma (DLBCL) in Patients with Systemic Lupus Erythematosus (SLE) (1526) Basile Tessier-Cloutier, Sasha Bernatsky, Eva Baecklund, Randy Gascoyne, Nathalie Johnson, Diane L Kamen, Ann E Clarke, Rosalind Ramsey-Goldman, Jennifer LF Lee, Pedro Farinha. Vancouver General Hospital, Vancouver, BC, Canada; McGill University Health Centre, Montreal, QC, Canada; Uppsala University, Uppsala, Sweden; British Columbia Cancer Agency, Vancouver, BC, Canada; Jewish General Hospital, Montreal, QC, Canada; Medical University of South Carolina, Charleston, SC; University of Calgary, Calgary, AB, Canada; Northwestern University, Chicago, IL. 252 Evaluation of FOXP1/S1PR2 and pstat3/s1pr1 in High Grade B Cell Lymphoma (1349) Mustafa Al-Kawaaz, Ghaith Abu Zeinah, John Allan, Wayne Tam, Teresa Sanchez, Michael Kluk. NYPH-Weill Cornell, New York, NY. 253 Prognostic Significance of TSC2 Expression in Diffuse Large B-cell Lymphoma (1392) Tony El Jabbour, Siddhartha Dalvi, Christine E Sheehan, Tipu Nazeer, Jeffrey Ross. Albany Medical College, Albany, NY. 254 Prognostic Significance of Telomere Length in Diffuse Large B-cell Lymphoma (1483) Anamarija Perry, Pamela Skrabek, Arshad Ahsanuddin, Ingo Schroedter, Chantalle Menard, Pascal Lambert, Joo Song, Dennis D Weisenburger, Michel Nasr. University of Manitoba, Winnipeg, MB, Canada; City of Hope National Medical Center, Duarte, CA. 255 Evaluation of De Novo Diffuse Large B-cell Lymphoma Using a Targeted Next Generation Sequencing Assay (1519) Joo Song, Anamarija Perry, Raju Pillai, Alex Herrera, Michel Nasr, Rebecca Ottesen, Janet Nikowitz, Pamela Skrabek, Leanne Goldstein, Christine McCarthy, Leticia Najera, Jasmine Zain, Jinhui Wang, Xiwei Wu, Auayporn Nademanee, Joyce Niland, Wing C Chan, Dennis D Weisenburger. City of Hope Medical Center, Duarte, CA; University of Manitoba, Winnipeg, MB, Canada; City of Hope, Duarte, CA. 256 De Novo Purine Biosynthetic Enzyme PAICS Upregulation in Diffuse Large B-Cell Lymphoma: Is It a Potential Target? (1406) Briana Gibson, Joseph Drwiega, Jennifer Gordetsky, Samara Roman-Holba, Yuri Kwon, Yang Yang, Sooryanarayana Varambally, Balabhadrapatruni VSK Chakravarthi, Deniz Peker. University of Alabama at Birmingham, Birmingham, AL. 257 Rapid Diagnosis of Aggressive Mature B-NHL Based on Graphic Presentation and Statistic Descriptions of FSC Parameters by Flow Cytometry (1497) Woodlyne Roquiz, James Huang. Oakland University William Beaumont School of Medicine, Royal Oak, MI. 251

312 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Large B-cell Lymphomas in Pediatric and Young Adult Population Are Genetically Heterogeneous (1409) Blanca Gonzalez-Farre, Olga Balagué, Idoia Martin- Guerrero, Marta Garrido, Ayman Gaafar, Mariona Suñol, Carmen Bárcena, Federico Garcia-Bragado, Maria del Mar Andres, Maitane Andion, Daniel Azorín, Itziar Astigarraga, Javier Molina-Garicano, Constantino Sábado, Soledad Gallego, Verónica Celis, Joan Enric Ramis-Zaldivar, Ivan Dlouhy, Armando Lopez- Guillermo, Rafael Fernandez-Delgado, Elias Campo, Itziar Salaverria. H.Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain; Faculty of Medicine, UPV/EHU, Bilbao, Spain; H. Cruces, Bilbao, Spain; H. Vall d Hebron, Barcelona, Spain; H.Sant Joan de Déu, Barcelona, Spain; H.12 de Octubre, Madrid, Spain; CH de Navarra, Pamplona, Spain; H. la Fe, Valencia, Spain; H. Infantil Niño Jesus, Madrid, Spain; Hospital Clinico, Valencia, Spain. 259 Diffuse Large B-Cell Lymphoma (DLBCL), No Otherwise Specified (NOS) in Chile. A Comparative Study (1533) Jose R Valbuena, Camila B Araya, Agustin I Gónzalez, Flavio Briones, Ricardo Molina, Claudia Cabezas, Roger Gejman, Alejandro H Corvalan. Pontificia Universidad Católica. Escuela de Medicina, Santiago, RM, Chile; Hospital Regional Puerto Montt, Puerto Montt, XI, Chile; Universidad de Concepción. Facultad de Medicina, Concepción, VIII, Chile. 260 Epidemiologic Observations in CD5+ Diffuse Large B-Cell Lymphoma (1524) Reka Szigeti, Esther Soundar, Nikhil Patel, Mohammad Haeri. Baylor College of Medicine, Houston, TX. 261 MEF2B-Mediated Activation of NOX-1 Pathway Contributes to the Lymphomagenesis of DLBCL of the Germinal Center Type (1393) Siraj M El Jamal, Hend Abulsayen, Barbara Bishop, Denise Kelley, Mostafa M Fraig, Ali G Saad, Mohamed Hassan. University of Mississippi Medical Center, Jackson, MS; University of Louisville, Louisville, KY; Tulane University, New Orleans, LA. 262 Expression of MEF2B Protein Is Correlated to the Expression of Germinal Center Markers CD10, GCET1, and LMO2 (1480) Tejal Patel, Hend Abulsayen, Sarag Boukhar, Myesa Emberesh, Ali G Saad, Elizabeth Chastain, Siraj M El Jamal. University of Mississippi Medical Center, Jackson, MS; University of Iowa, Iowa City, IA; Bronx-Lebanon Hospital Center, Bronx, NY. 263 The Incorporation of MEF2B in DLBCL Immunostains Algorithms: A Tissue Microarray Comparative Study (1361) Anas Bernieh, Mohamed El Dinali, Hend Abulsayen, Xinchun Zhou, Ali G Saad, Elizabeth Chastain, Siraj M El Jamal. University of Mississippi Medical Center, Jackson, MS; University of Miami, Miami, FL. 264 Comparison of Myocyte Enhancer Factor 2B (MEF2B) versus Other Germinal Center-Associated Antigens in the Differential Diagnosis of B-cell Lymphomas (1458) Erika M Moore, Steven H Swerdlow, Sarah E Gibson. University of Pittsburgh School of Medicine, Pittsburgh, PA. 265 Myocyte Enhancer Factor 2B (MEF2B) and J Chain Are Useful in Differentiating Classical Hodgkin Lymphoma (CHL) from Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) and Primary Mediastinal Large B-cell Lymphoma (PMBL) (1459) Erika M Moore, Steven H Swerdlow, Sarah E Gibson. University of Pittsburgh School of Medicine, Pittsburgh, PA. 266 Diagnostic Utility of CD19 and CD22 Immunohistochemistry in the Diagnosis of Hodgkin and Large B Cell Lymphomas (1455) Emily F Mason, Geraldine Pinkus. Brigham and Women s Hospital, Boston, MA. 267 Dendritic Markers Aid in Distinguishing Mediastinal Gray Zone Lymphoma from Classical Hodgkin Lymphoma and Primary Mediastinal Large B-Cell Lymphoma (1481) Kevin T Pelland, Stephanie P Mathews, Anitha Kamath, Paul J Cohen, Stanley D Hudnall, Mina L Xu. Yale-New Haven Hospital, New Haven, CT; University of North Carolina School of Medicine, Chapel Hill, NC. 268 Tumor-Associated Macrophages Do Not Predict Survival in Relapsed/refractory Hodgkin Lymphoma Treated with Autologous Stem Cell Transplantation (1515) Parwiz Siaghani, Joo Song, Yuan Yuan Chen, Dennis D Weisenburger, Young Kim. City of Hope National Medical Center, Duarte, CA; Cit of Hope National Medical Center, Duarte, CA. 269 Clinicopathologic Characterization of Nodular Lymphocyte-Predominant Hodgkin Lymphoma from Kenya (1547) Daniel Xia, Shahin Sayed, Zahir Moloo, Samuel Gakinya, Anderson Mutuiri, Elizabeth L Courville, Robert P Hasserjian, Aliyah Sohani. Massachusetts General Hospital, Boston, MA; Aga Khan University Hospital, Nairobi, Kenya; University of Minnesota, Minneapolils, MN. 270 OCT2/CD57 Double Stain: A Useful Tool for an Accurate Diagnosis of Nodular Lymphocyte Predominant Hodgkin Lymphoma (1465) Anna Nam, Amy Chadburn, Wayne Tam. Weill Cornell Medicine, New York, NY. 271 Exploring the Tumor Clonal Dynamics Between Diffuse Large B-Cell Lymphomas (DLBCL) and Bone Marrow (BM) Involvement by Deep Immunoglobulin Heavy Chain (IGH) VDJ Sequencing (1463) Anna Nam, Jiao Ma, David Redmond, Kui Nie, Attilio Orazi, Olivier Elemento, Wayne Tam. Weill Cornell Medicine, New York, NY. 252

313 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Molecular Fingerprinting of Anatomically and Temporally Distinct B-cell Lymphoma Samples by NGS to Establish Clonal Relatedness (1457) Anna P Matynia, K David Li, Jonathan Schumacher, Philippe Szankasi, Todd W Kelley. University of Utah, Salt Lake City, UT; ARUP Laboratories, Salt Lake City, UT. 273 Ultrasensitive Two Color RNA In Situ Hybridization for Kappa and Lambda on an Automated Staining System Detects B-cell Clonality with Performance Comparable or Superior to Flow Cytometry (1415) Ling Guo, Zhen Wang, James R Cook. Cleveland Clinic, Cleveland, OH. 274 PD-L1 Up-Regulation in Tumour/Microenvironment Is Associated with LMP-1 Expression as a Constitutive Activation Mechanism Not Correlated with PD-1 Positivity in Post-Transplant Lymphoproliferative Disorders (1534) Luis Veloza, Blanca González-Farré, Mileyka Herrera, Antonio Martinez. Hospital Clínic, Barcelona, Spain. 275 B-cell Post-Transplant Lymphoproliferative Disorder Isolated to the Central Nervous System Is EBV-Positive, Lacks p53 and Myc Expression by Immunohistochemistry, and Can Have Numerous Background T-Lymphocytes (1522) Andrew Sundin, Elizabeth L Courville. University of Minnesota Medical School, Minneapolis, MN; University of Minnesota, Minneapolis, MN. 278 Fibrin-Associated EBV+ Large B-Cell Lymphoma: An Indolent Neoplasm Distinct from DLBCL-CI (1363) Daniel Boyer, Penelope McKelvie, Laurence de Leval, Kerstin L Edlefsen, Young-Hyeh Ko, Zachary Aberman, Alexandra Kovach, Aneal Masih, Ha Nishino, Lawrence Weiss, Alan Meeker, Valentina Nardi, Maryknoll Palisoc, Lina Shao, Stefania Pittaluga, Judith A Ferry, Nancy Harris, Aliyah Sohani. University of Michigan, Ann Arbor, MI; Massachusetts General Hospital, Boston, MA; St. Vincent s Hospital, Melbourne, Australia; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; University of Washington, Seattle, WA; Sungkyunkwan University, Seoul, Republic of Korea; Florida International University, Miami, FL; Vanderbilt University, Nashville, TN; Holmes Regional Medical Center, Melbourne, FL; North Shore Medical Center, Salem, MA; NeoGenomics Laboratories, Aliso Viejo, CA; Johns Hopkins University, Baltimore, MD; National Cancer Institute, Bethesda, MD. 279 Activation-Induced Cytidine Deaminase (AID) Is Frequently Expressed in HIV-Associated Diffuse Large B-cell Lymphoma (DLBCL) (1514) Volodymyr Shponka, Page Bracci, Lisa Rimsza, Samantha Kendrick. University of Arizona, Tucson, AZ; UCSF, San Francisco, CA; Mayo Clinic Arizona, Scottsdale, AZ. KIDNEY/RENAL PATHOLOGY 276 Plasmablastic Post-Transplant Lymphoproliferative Disorder Is Clinically and Genetically Heterogeneous (1489) Patricia Raciti, Nupam Patel, Susan J Hsiao, Bachir Alobeid, Mahesh M Mansukhani, Govind Bhagat. Columbia University Medical Center, New York, NY. 277 Clinicopathologic Analysis of Iatrogenic Immunodeficiency Associated Lymphoproliferative Disorders (ILPD) in a Non-Transplant Setting: Report of 8 Cases from a Single Institution (1387) Michelle Don, Joseph Vallone, Mariza de Peralta- Venturina, Qin Huang. Cedars-Sinai Medical Center, Los Angeles, CA. 280 Post-Transplant Thrombotic Microangiopathy Associated with a Monoclonal Gammopathy: A Case Series (1641) Aishwarya Ravindran, Ronald S Go, Fernando C Fervenza, Sanjeev Sethi. Mayo Clinic, Rochester, MN. 281 Post-Transplant Thrombotic Microangiopathies: A Case Series (1642) Aishwarya Ravindran, Ronald S Go, Fernando C Fervenza, Sanjeev Sethi. Mayo Clinic, Rochester, MN. 282 Decreasing Incidence of Tubular Basement Membrane Immune Deposits in Polyomavirus Nephropathy (1633) Meghan Kapp, Yasemin Ozluk, Anthony Langone, Harold Helderman, Donald Franklin, Mandeep Grewal, Agnes Fogo. Vanderbilt University Medical Center, Nashville, TN; Instanbul University, Istanbul, Turkey; Nephrology Associates of Chattanooga, Chattanooga, TN. 283 BK Virus Disease Severity and Predictors of Graft Outcomes in Renal Transplants: A Single Institution Experience (1645) Melissa Swee, Sook-kyung Kwon, M L Sanders, Mony Fraer, Sarat Kuppachi, Prerna Rastogi. University of Iowa, Iowa City, IA. 253

314 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Pathology of Obstruction in Pediatric Renal Allografts, a Mechanism of Interstitial Fibrosis in Renal Transplantation (1650) Chen Yang, Joseph Gaut. Washington University Medical Center, St. Louis, MO. 285 Optimal Tissue Preparation of Donor Kidney Biopsies for Rapid Digital Pathology Interpretation (1620) Jie Chen, Satoru Kudose, Joseph Gaut. Washington University in St. Louis, St. Louis, MO. 286 The Role of Transplant Pathologists in Assessing Non- Routine Surgical Specimens from Deceased Donors During Preimplantation Kidney and Liver Biopsies: A 7 Year Retrospective Analysis (1631) Kenneth T Hughes, Shuling Zheng, Stephen C Ward, Fadi Salem. Mount Sinai Medical Center, New York, NY. 287 Post-Transplant Lymphoproliferative Disorder (PTLD) in Kidney Transplant (KTx) Recipients (1652) Pingchuan Zhang, Rebecca King, Kay M Ristow, Fernando Cosio, Lynn D Cornell, Thomas M Habermann, Mariam P Alexander. Mayo Clinic, Rochester, MN. 288 Donor-Derived Metastatic Melanoma Transmitted Through Kidney Allograft (1617) Shaymaa AL-L Ashi, Andrei Plagov, Alden Doyle, Suzanne M Boyle, Suganthi Soundararajan. Drexel University, Philadephia, PA. 289 Increasing Tumor Burden in Radical Nephrectomy Specimens (RN) Corresponds to a Positive Delta in Estimated Glomerular Filtration Rate Over Time (1648) Melanie Wooten, Muhammad Hassan, Thomas Rogers, Alton B Farris, Kenneth Ogan, Carla Ellis. Emory University, Atlanta, GA; Howard University, Washington, DC. PANCREAS & BILIARY TREE 290 Surgical Resection of the Pancreas for Benign Conditions: A Ten-Year Single Center Retrospective Review (1769) Daniel W Abbott, Kiyoko Oshima. Medilca College of Wisconsin, Milwaukee, WI. 291 Paraduodenal Pancreatitis (PDP) Shows Histomorphologic Mimicry of Autoimmune Pancreatitis (AIP): An Analysis of 62 PDP Reveals Common Occurrence of Periductal Lymphoplasmacystic Infiltrates with IgG4 Positive Cells and Granulocytic Epithelial Lesions (1799) Takashi Muraki, Michelle D Reid, Grace E Kim, Gabriella Bedolla, Yue Xue, Bahar Memis, Hyejeong Choi, Ipek Erbarut, Alyssa Krasinskas, David Kooby, Shishir Maithel, Juan M Sarmiento, Volkan Adsay. Emory Uni., Atlanta, GA; Uni. of California, San Francisco, San Francisco, CA; Ulsan Uni., Seoul, Korea. 292 The Nature of Cystic Lesions > 1 cm Associated with Pancreatic Ductal Adenocarcinoma (1800) Takashi Muraki, Kee-Taek Jang, Michelle D Reid, Yue Xue, Bahar Memis, Pardeep Mittal, Alyssa Krasinskas, David Kooby, Shishir Maithel, Juan M Sarmiento, Volkan Adsay. Emory Uni., Atlanta, GA; SMC, Seoul, Korea. 293 Gene Expression Analysis of Low and High Grade Pancreatic Intraepithelial Neoplasia (PanIN) (1793) Celia Marginean, Venus Chirip, Bryan Lo. The Ottawa Hospital, Ottawa, ON, Canada; The Ottawa Hospital Research Institute, Ottawa, ON, Canada. 294 Molecular Correlates of Major Morphologic Subtypes of Pancreatic Ductal Adenocarcinoma (1803) Jonathan A Nowak, Yiru Wu, Zhirong Qian, Douglas A Rubinson, Vicente Morales-Oyarvide, Richard F Dunne, Jennifer J Findeis-Hosey, Jason L Hornick, Lauren Brais, Annacarolina Da Silva, Marisa Welch, Chen Yuan, Margaret Kozak, Matthew Ducar, Aaron Thorner, Bruce Wollison, Charles Fuchs, Shuji Ogino, Aram Hezel, Albert Koong, Brian Wolpin. Brigham and Women s Hospital, Boston, MA; Dana- Farber Cancer Institute, Boston, MA; The University of Rochester, Rochester, NY; Stanford University, Stanford, CA. 295 Validation of Ampulla of Vater Cancer Staging form the 8 th Edition of the American Joint Committee on Cancer Staging System (1790) Sung Joo Kim, Soyeon An, Eunsil Yu, Seung-Mo Hong. Asan medical center, Seoul, Korea. 296 SMAD4 Loss in Pancreaticobiliary, Gastrointestinal and Extra-Gastrointestinal Carcinomas (1809) Lauren Ritterhouse, Kim Woo Kyung, Deborah A Dillon, Michelle S Hirsch, Lynette M Sholl, Agoston Agoston, Namrata Setia, Gregory E Lauwers, Do Youn Park, Amitabh Srivastava, Leona Doyle. Brigham and Women s Hospital & Harvard Medical School, Boston, MA; Pusan National University Medical School, Busan, Korea; The University of Chicago, Chicago, IL; UCSF, San Francisco, CA. 297 Combination Immunohistochemistry for SMAD4 and Runt-Related Transcription Factor 3 (RUNX3) May Identify a Favorable Prognostic Subgroup of Pancreatic Ductal Adenocarcinomas (1792) Yangkyu Lee, Hyejung Lee, Hyunjin Park, Jin-Won Kim, Jin-Hyeok Hwang, Jaihwan Kim, Yoo-Seok Yoon, Ho- Seong Han, Haeryoung Kim. Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, Republic of Korea. 298 SMAD4 Expression in Pre-Treatment Fine Needle Aspiration Specimens Versus Post-Treatment Surgical Specimens in Patients with Pancreatic Ductal Adenocarcinoma (1770) Amrou Abdelkader, Kiyoko Oshima, Alexander C Mackinnon. Medical College of Wisconsin, Milwaukee, WI. 254

315 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall Measured Residual Tumor Cellularity Correlates with Survival in Neoadjuvant Treated Pancreatic Ductal Adenocarcinoma (1810) Daniel Rowan, Valentina Logunova, Kiyoko Oshima. Medical College of Wisconsin, Milwaukee, WI. 300 Expression and Subcellular Localization of Eukaryotic Initiation Factor 3 Subunit f (eif3f) Is Altered in Pancreatic Ductal Adenocarcinoma (PDA) and Its Precursor Lesions (1812) Shula Schechter, Brittany Silverman, Lili Zhao, Jiaqi Shi. University of Michigan, Ann Arbor, MI. 301 Programmed Cell Death Ligand 1 Cut-Point Is Associated with Disease Specific Survival in Resected Pancreatic Ductal Adenocarcinoma (1787) Steve E Kalloger, Basile Tessier-Cloutier, Katy Milne, Christine Chow, Dongxia Gao, Daniel J Renouf, David Schaeffer. University of British Columbia, Vancouver, BC, Canada; British Columbia Cancer Agency, Victoria, BC, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada; Vancouver General Hospital, Vancouver, BC, Canada; Pancreas Centre BC, Vancouver, BC, Canada. 302 Is Routine Histologic Examination of Gallbladders Necessary? (1783) Yuna Gong, Monica Garcia-Buitrago, Claudia Rojas, Clara Milikowski, Nilesh Kashikar. University of Miami Hospital, Miami, FL. 303 Effect of Sampling on the Prevalence of In Situ/ Invasive Gallbladder Carcinoma (1784) Ezgi Hacihasanoglu, Esra Pasaoglu, Nevra Dursun. Istanbul Education and Research Hospital, Istanbul, Turkey. 304 Pathologic Findings from Totally Sampled and Mapped Gallbladders in a High-Risk Population (1774) Enrique Bellolio, Juan Carlos Roa, Miguel Villaseca, Catterina Ferreccio, Volkan Adsay, Hector Losada, Alison Van Dyke, Carolina Vivallo, Renato Becker, Karie Medina, Patricia Fuentealba, Juan Carlos Araya, Jill Koshiol. Universidad de La Frontera, Temuco, Chile; P. Universidad Católica de Chile, Santiago, Chile; Emory University, Atlanta, GA; NCI, Rockville, MD. 305 F.I.S.H. ing to Verify the Nature of Different Epithelial Alterations in the Gallbladder: Molecular Abnormalities Are Common in Neoplastic but Not in Reactive Lesions, Thus Validating the Santiago Criteria and Potential Usefulness of F.I.S.H. as an Adjunct in Diagnosis (1808) Michelle D Reid, Rondell Graham, Bahar Memis, Benjamin Kipp, Emily Barr Fritcher, Juan Carlos Roa, Juan Carlos Araya, Miguel Angel Villaseca, Enrique Bellolio, Hector Losada, Juan M Sarmiento, Jill Koshiol, Volkan Adsay. Emory, Atlanta, GA; Mayo Clin, Rochester, MN; Pontificia Uni. Católica de Chile, Santiago, Chile; Uni de La Frontera, Temuco, Chile; NIH, Bethesda, MD. 306 Prognostic Validation of T2-Substaging of Gallbladder Carcinomas: Survival Analysis of 127 Korean Cases with T2 Substaging and Survival Correlation (1778) Jinah Chu, Kee-Taek Jang, Juan Carlos Roa, Seung- Mo Hong, Kyoung Bun Lee, Jill Koshiol, Bahar Memis, Takashi Muraki, Michelle D Reid, Michael M Goodman, Rebecca Nash, Jinyoung Jang, Volkan Adsay, Haeryoung Kim, Hyejeong Choi. Samsung Medical Center, Seoul, Korea; Pontificia Universidad Católica de Chile, Santiago, Metropolitana, Chile; Asan Medical Center, Seoul, Korea; Seoul National University Hospital, Seoul, Korea; Seoul National Bundang Hospital, Seongnam, Gyeonggido, Korea; Ulsan University Hospital, Ulsan, Korea; National Cancer Institute, Rockville, MD; Emory University Hospital, Atlanta, GA. 307 Rhabdoid Gallbladder Carcinomas Show Loss of SMARCA4 or SMARCB1 (1786) Andrea Jones, Bita V Naini, Dora M Lam-Himlin, Jennifer M Boland, Michelle D Reid, Volkan Adsay, Rondell Graham. Mayo Clinic, Rochester, MN; UCLA, Los Angeles, CA; Mayo Clinic, Scottsdale, AZ; Emory University, Atlanta, GA. TECHNIQUES (INCLUDING ULTRASTRUCTURE) 308 Validation and Optimization of an Automated mrna In Situ Assay Workflow Using RNAscope and Digital Pathology for Gene Expression Analysis of Formalin Fixed Tissues in the Pathology Laboratory (2153) Pamela Villalobos, Barbara Mino, Ignacio I Wistuba, Anna Yemelyanova, Jaime Rodriguez-Canales. The University of Texas M.D. Anderson Cancer Center, Houston, TX. 309 Detection of Somatic Mutations in FFPE Tumor Tissues by BaseScope Assay, a Novel Chromogenic RNA In- Situ Hybridization Method (2156) Xiao-Ming M Wang, Xingyong Wu, Liuliu Pan, Jeff Kim, Fan Lin, Nan Su, Emily Park, Robert Monroe, Yuling Luo, Xiao-Jun Ma. Advanced Cell Diagnostics, Newark, CA; Geisinger Clinic, Danville, PA. 310 Nanostring Copy Variation Assay Is Very Sensitive in Identifying EGFR Amplification but Is Less Sensitive in Identifying Deletions in 1p/19q and PTEN Compared to FISH in Brain Tumors Samples (2112) Hanan Armanious, Iyare Izevbaye. University of Alberta, Edmonton, AB, Canada. 311 Comparison of 3 MYC Fluorescence In Situ Hybridisation Probes and Manual versus Semi- Automatic Staining Methods; a Tissue Microarray- Based Study on 57 Lymphomas (2115) James Boers, Ed Schuuring. Isala Hospital, Zwolle, Netherlands; University Medical Center Groningen, Groningen, Netherlands. 255

316 ABSTRACTS POSTER SESSION POSTER VI SESSION Wednesday, Day, March Date, 08, :00 1:00 AM PM - 0:00 4:00 PM Exhibit Hall RNA In Situ Hybridization Using Quantigene ViewRNA 2.0 Branched DNA Signal Amplification Technology Shows PGC1B and ESRRA Are Transcriptionally Upregulated Late in Colon Cancer Development (2124) Kurt Fisher, Binita Das, Beth Clymer, Geoffrey Talmon, Robert Lewis. University of Nebraska Medical Center, Omaha, NE. 313 Dual-Color, Break-Apart FISH Assay on Paraffin- Embedded Tissues as an Adjunct to Diagnosis of Small Round Cell Sarcomas with CIC Translocation (2147) Christian Salib, Daniel L Van Dyke, Patricia Adem, John T Fallon, Chitra Kumar, Minghao Zhong. Westchester Medical Center/ New York Medical College, Valhalla, NY; Mayo Clinic, Rochester, MN. 314 Detection of FGFR1-PLAG1 Fusion in Salivary Carcinomas Ex Pleomorphic Adenoma by Fluorescence In Situ Hybridization and Next Generation Sequencing (2122) Soufiane El Hallani, Simion Chiosea. University of Pittsburgh, Pittsburgh, PA. 315 Chromogenic Detection of CRTC1-MAML2 Fusion Event in Mucoepidermoid Carcinoma Samples Using a Novel RNA ISH Assay (2116) Betty Booker, Xiao-Ming Mindy Wang, Li-Chong Wang, Xingyong Wu, Yuling Luo, Nan Su, Emily Park, Joaquin Garcia, Robert Monroe, Xiao-Jun Ma. Advanced Cell Diagnostics, Fremont, CA; Mayo Clinic, Rochester, MN. 316 Whole Exome Sequencing of Neuroendocrine Neoplasms of Ovarian Origin (2154) Moiz Vora, Yin Hong, Adam H Greer, Eric X Wei, Rodney Shackelford. Louisiana State University Health Sciences Center, Shreveport, LA. 317 Next-Generation Sequencing: Clinical Implementation in the Routine Diagnosis of Translocation-Associated Bone and Soft Tissue Tumors (2151) David Swanson, Sharon Crafter, Andrew Wong, Evangeline Agro, George Charames, Rita A Kandel, Brendan C Dickson. Mount Sinai Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. 318 Validation of NGS Detection of the Mutations in the Hematopoietic Disorders with Large Myeloid Panel (2159) Richard Wu, Shuai Wen. Unversity of Miami, Miami, FL. 319 Sensitive and Specific Detection of Mutations in Circulating Tumor DNA with Anchored Multiplex PCR and Next-Generation Sequencing (2119) Brady P Culver, Jerome E Lee, Josh Haimes, Namitha Manoj, Eric M Davis, Ian McKittrick, Katelyn E Trifilo, Laura A Johnson, Laura Griffin, Brian Kudlow. ArcherDX, Inc., Boulder, CO. 320 Assessing the Clinical Utility of Expanded vs. Small Targeted Solid Tumor NGS Panels (2129) Amin A Hedayat, Jason D Peterson, Julie Y Tse, Cheryl L Eifert, Torrey L Gallagher, Sophie J Deharvengt, Francine B de Abreu, Gregory J Tsongalis. Geisel School of Medicine at Dartmouth, Hanover, NH; Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH; KEW, Inc., Cambridge, MA. 321 Diagnostic Efficiency in Digital Pathology: A Comparison of Optical vs. Digital Assessment in 500 Surgical Pathology Cases (2138) Anne Mills, Sarah E Gradecki, Christopher A Moskaluk, Bethany J Horton, Rebecca Blackwell, James W Mandell, Stacey E Mills, Helen P Cathro. University of Virginia, Charlottesville, VA. 256

317 ABSTRACTS POSTER ABSTRACT SESSION ASSIGNMENT COMMITTEE Day, Date, :00 AM - 0:00 PM Committee Member Term Ending Jason L. Hornick, M.D., Ph.D. Chair 2017 Justine Barletta, M.D Justin Bishop, M.D Leona Doyle, M.D Daniel Dye, M.D Brad Ferris, M.D Ryan Gill, M.D., Ph.D David Hwang, M.D., Ph.D Kristin Jensen, M.D Robin D. LeGallo, M.D Dylan V. Miller, M.D Elizabeth Morgan, M.D Committee Member Term Ending Juan-Miguel Mosquera, M.D Ericka Olgaard, D.O Rajiv Patel, M.D Alexandros Polydorides, M.D., Ph.D Bobbi S. Pritt, M.D Charles M. Quick, M.D Raga Ramachandran, M.D., Ph.D Michael Roh, M.D., Ph.D Sandro Santagata, M.D., Ph.D Shree G. Sharma, M.D Maria Westerhoff, M.D Sean R. Williamson, M.D Laura Wood, M.D., Ph.D ABSTRACT REVIEW BOARD Hikmat Al-Ahmadie Christina Arnold David Bahler Ul Balis Guliz Akdas Barkan Justine Barletta Olca Basturk Sean Bendall Dan Berney Ritu Bhall Parul Bhargava Justin Bishop Jennifer Black Thomas Brenn Fadi Brimo Anne Buckley Natalia Buza Ben Calhoun Benjamin Chen Yingbei Chen Rebecca Chernock Andres Chiesa-Vottero Brian Collins Lynn Cornell Claudiu Cotta Tim D Alfonso Robin DeGallo Leona Doyle Daniel Dye Brad Farris Yuri Fedoriw Dennis Firchau Ann Folkins Karen Fritchie Karuna Garg James Gill Ryan Gill Raul Gonzalez Jennifer Gordetsky Ilyssa Gordon Alejandro Gru Omar Habeeb Marc Halushka Krisztina Hanley Yael Heher Walter Henricks Brooke Howitt David Hwang Michael Idowu Muhammad Idrees Joe Jakowski Kristin Jensen Vickie Jo Nicole Johnson Michael Kluk Kristine Konopka Melinda Lerwill Rebecca Levy Jingmei Lin Kelly Magliocca Joe Maleszewski Anais Malpica Adrian Marino-Enriquez Jonathan Marotti Jerri McClemore Rohit Mehra Ozgur Mete Dylan Miller Mari Mino- Kenudson Roberto Miranda Andre Moreira Elizabeth Morgan Juan Miguel Mosquera Atis Muehlenbachs Sanjay Mukhopadhyay Anna Marie Mulligan Behzad Najafian Raouf Nakhleh Ilke Nalbantoglu Ericka Olgaard Horatiu Olteanu Michele Paessler Carlos Parra-Herran Rajiv Patel Joanna Phillips David Pisapia Jenny Pogoriler Alexi Polydorides Sonam Prakash Bobbi Pritt Christopher Przybycin Charles Quick Raga Ramachandran Vijaya Reddy Robyn Reed Michelle Reid Natasha Rekhtman Michael Roehrl Mike Roh Marianna Ruzinova Peter Sadow Safia Salaria Sandro Santagata Stephen Schmechel Frank Schneider Theresa Scognamiglio Michael Seidman Shree Sharma Steven Shen Chanjuan Shi Wun-Ju Shieh Konstantin Shilo Lauren Smith Steven Smith Aliyah Sohani Paul Staats Heather Stevenson-Lerner Khin Thway Maria Tretiakova Evi Vakiani Russell Vang Marina Vivero Wei-Lien (Billy) Wang Yihong Wang Christopher Weber Astrid Weins Maria Westerhoff Sean Williamson Laura Wood Wei Xin Mina Xu Xuefeng Zhang 257

318 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 16 Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties. 31 Brian P Rubin PI for Philips; Research Grant. 40 Torsten Nielsen Breast cancer test licensing for Nanostring; Royalties. 42 Vikram Deshpande Research support for Affymetrix; Research support to institution. 43 Janis M Taube Advisory board for Bristol Myers Squibb; Honorarium. Advisory board for Merck; Honorarium. Advisory board for Astra Zeneca; Honorarium. Investigator-initated Research for Bristol Myers Squibb; Research Funding. 62 Vikram Deshpande Research support for Affymetrix; Research support to institution. 74 Brian P Rubin PI for Philips; Research Grant. 78 Richard L McGough Consultant for Stryker; Not relevant to this presentation. Consultant for IlluminOss; Not relevant to this presentation. 109 Sunil Badve Founder of SysGenomics; Founder Shares. 109 Yesim Gokmen-Polar Founder of SysGenomics; Founder Shares. 109 Steven A Buechler Founder of SysGenomics; Founder Shares. 117 Andrew H Beck Co-founder and CEO for PathAI, Inc.; Ownership interest. 118 Vikram Deshpande Research support for Affymetrix; Research support to institution. 121 Andrew H Beck Co-founder and CEO for PathAI, Inc.; Ownership interest. 122 Krista Catlow Employment of Roche; Employment. Employment of Roche; Stock. 122 Brian Mosteller Employment of Roche; Employment. Employment of Roche; Stock. 122 Daniel Warren Employment of Roche; Employment. Employment of Roche; Stock. 122 Kate Leith Employment of Roche; Employment. Employment of Roche; Stock. 122 Julia Coach Employment of Roche; Employment. Employment of Roche; Stock. 122 Amy Hanlon-Newell Employment of Roche; Employment. Employment of Roche; Stock. 122 Raymond Jones Employment of Roche; Employment. Employment of Roche; Stock. 123 Daniel F Hayes PI of study for Janssen; Research support. Inventor of patent for CTC held by U.Michigan for Janssen; Royalties. PI for Astra Zeneca; Research support. Advisory board for Inbiomotion; Stock options. Advisory board for OncImmune; Stock options. 123 Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support. 132 Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 132 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 146 Alejandro Gru Consultant for Seattle Genetics; Honorarium. 146 Anne Mills Trial participation for Philips Digital Pathology; Salary support. 163 Yesim Gokmen-Polar Founder of SysGenomics; Founder Shares. 163 Sunil Badve Founder of SysGenomics; Founder Shares. 180 Hiroaki Nitta Employee of Ventana; Salary. 180 Peter Banks Employee of Ventana; Salary. 187 Anant Madabhushi Equity holder for Elucid Bioimaging; Equity holder. Scientific advisory Consultant for Inspirata Inc.; Equity holder. 196 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest. 196 Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 196 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 197 Nefize S Kip Speaker for Nanostring; I have not receieved any but I may in future for providing technology seminars to their internal staff. 201 Jane Brock Cepheid paid for the cost of mrna analysis for Cepheid; Research funding support. 212 Hiroaki Nitta Employee of Ventana; Salary. 212 Peter Banks Employee of Ventana; Salary. 213 Hiroaki Nitta Employee of Ventana; Salary. 213 Peter Banks Employee of Ventana; Salary. 232 Ken Ho Employee of Cepheid; Salary. 232 Natalie Wu Employee of Cepheid; Salary. 232 Annnaliza Rizo Employee of Cepheid; Salary

319 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 232 Edwin W Lai Employee of Cepheid; Salary. 232 Weidler Jodi Employee of Cepheid; Salary and stock. 232 Wong Wendy Employee of Ceheid; Salary. 232 Michael Bates Employee of Cepheid; Salary. 232 Jane Brock Cepheid paid for the cost of mrna analysis for Cepheid; Research funding support. 238 Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 238 Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest. 238 Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 238 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 242 Brian P Rubin PI for Philips; Research Grant. 244 Janet K Horton PI for Varian Medical Systems; Research Funding. 248 Frederique Penault-Llorca Consultant and Speaker for Roche; Honorarium et Research Grants. Consultant and Speaker for Merck; Honorarium. 248 David Azria Speaker for Roche; Honorarium and Research Grants. 266 Jean F Simpson President for Breast Pathology Consultants; Ownership. 281 Janis M Taube Advisory board for Bristol Myers Squibb; Honorarium. Advisory board for Merck; Honorarium. Advisory board for Astra Zeneca; Honorarium. Investigator-initated Research for Bristol Myers Squibb; Research Funding. 282 Janis M Taube Advisory board for Bristol Myers Squibb; Honorarium. Advisory board for Merck; Honorarium. Advisory board for Astra Zeneca; Honorarium. Investigator-initated Research for Bristol Myers Squibb; Research Funding. 315 Javid Moslehi for Bristol-Myers Squibb, Ariad, Novartis, Pfizer, RGenix, Takeda, Verastem, Vertex, Janssen; Consulting, Advisory. 340 David L Rimm Consultant for Astra Zeneca; Honorarium. Consultant for Bristol Meyers Squibb; Honorarium. Consultant for Cell Signaling Technology; Honorarium. Consultant for Perkin Elmer; Honorarium. Consultant for Ultivue; Honorarium. 425 Yuri Nikiforov Consultant for Quest Diagnostics; Consulting fee. for Commercial contract between UPMC and CBLPATH, Inc. 438 Long Le Technology and licensing of technology for Archer Dx; Royalties, and equity. 438 Anthony Iafrate Licensing of technology for ArcherDx; Equity and royalties. 458 Christopher Teshima Investigator-initiated study for MedTronic; Research support (equipment). 458 Catherine Streutker Speaker for Medtronic; Honorarium. 464 Andrew H Fischer For sales of CellientTM Cell Block technology for Hologic, Inc; Royalties. 496 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest. 496 David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 496 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 500 Brian P Rubin PI for Philips; Research Grant. 518 Colleen Rock Employee of Myriad Genetics Laboratories; Salary and stock options. 518 Hillary Kimbrell Employee of Myriad Genetic Laboratories; Salary and Stock options. 518 Darl Flake Employee of Myriad Genetic Laboratories; Salary and Stock options. 518 M Bryan Warf Employee of Myriad Genetic Laboratories; Salary, Stock Options. 518 Jonathan Nelson Employee of Myriad Genetic Laboratories; Salary and Stock Options. 518 Thaylon Davis Employee of Myriad Genetic Laboratories; Salary, Stock Options. 518 Catherine Miller Employee of Myriad Genetic Laboratories; Salary and Stock Options. 518 Kristen Rushton Employee of Myriad Genetic Laboratories; Salary and Stock Options. 259

320 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 518 Anne-Renee Hartman Employee of Myriad Genetic Laboratories; Salary and Stock Options. 518 Richard Wenstrup Employee of Myriad Genetic Laboratories; Salary and Stock Options. 518 Loren Clarke Employee of Myriad Genetic Laboratories; Salary and Stock Options. 519 Brian P Rubin PI for Philips; Research Grant. 530 Anthony P Fernandez Speaker, Advisory, Research for AbbVie; Honorarium. Speaker for Celgene; Honorarium. Consultant for Novartis; Honorarium. 534 Brian P Rubin PI for Philips; Research Grant. 539 Anne Mills Trial participation for Philips Digital Pathology; Salary support. 539 Craig L Slingluff Member, Scientific advisory board for Inmmatics; Funds to UVA. Principal investigator, MAVIS cancer vaccine trial for Polynoma; Funds to UVA. Grant Support for Clinical Trial for Glaxo Smith Kline; Grant Support. 539 Alejandro Gru Consultant for Seattle Genetics; Honorarium. 544 Michael Bonert Founder / owner of Libre Pathology Limited; No finanical benefit. Company runs librepathology.org - an open access creative commons licensed pathology wiki - without commercial sponsorship or advertisements. 579 Sylvia L Asa Medical Advisory board for Leica Aperio; Honorarium. 581 Peter M Sadow Tie-breaker for diagnoses of anonymous cases for Veracyte; Payment for case review. 582 Sylvia L Asa Medical Advisory board for Leica Aperio; Honorarium. 582 Virginia A LiVolsi Consultant for Veracity, Inc; Honorarium. 582 Yuri Nikiforov Consultant for Quest Diagnostics; Consulting fee. for Commercial contract between UPMC and CBLPATH, Inc. 587 Rocio P López Investigador for Novartis Colombia; Support during the protocol elaboration (Statistic methodology) and partial sponsorship for the protocol execution. 587 Luis E Barrera-Herrera Investigator for Novartis Colombia; Support during the protocol elaboration (Statistic methodology) and partial sponsorship for the protocol execution. 587 María M Torres Investigator for Novartis Colombia; Support during the protocol elaboration (Statistic methodology) and partial sponsorship for the protocol execution. 587 Sandra Vega Investigator for Novartis Colombia; Support during the protocol elaboration and partial sponsorship for the protocol execution. 598 Virginia A LiVolsi Consultant for Veracity, Inc; Honorarium. 600 Yuri Nikiforov Consultant for Quest Diagnostics; Consulting fee. for Commercial contract between UPMC and CBLPATH, Inc. 630 Mamoun Younes President for Olive Tree Media LLC; Shares. 631 David T Ting Speaker for Affymetrix; Honorarium. PI for Affymetrix; Sponsored Research. 631 Vikram Deshpande Researcher for Affymetrix; Research Support. 676 Nir Modiano Advisory board for Takeda; Honorarium. 691 Catherine Streutker Speaker for Medtronic; Honorarium. 694 Heather Hampel Principal Investigator for Myriad Genetic Laboratories, Inc; Research genetic testing. Clinical Advisory board for InVitae Genetics; Honorarium. Speaker for Beijing Genomics Institute; Honorarium. 708 Vikram Deshpande Researcher for Affymetrix; Research Support. 746 Heather Hampel Principal Investigator for Myriad Genetic Laboratories, Inc; Research genetic testing. Clinical Advisory board for InVitae Genetics; Honorarium. Speaker for Beijing Genomics Institute; Honorarium. 755 William R Taylor Technology licensing agreement with Mayo Clinic for Exact Sciences; Laboratory funding/potential future product royalties. 755 Tracy C Yab Future Products Royalties for Exact Sciences; Licensing agreement. 755 John B Kisiel Intellectual property development for Exact Sciences, Madison WI; Research funding, royalties. 761 Ralph H Hruban PALB2 Invention for Myriad Genetics; Royalty Payments. 763 Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 763 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 765 Vikram Deshpande Researcher for Affymetrix; Research Support. 779 Frederique Penault-Llorca Consultant and Speaker for Roche; Honorarium et Research Grants. Consultant and Speaker for Merck; Honorarium. 779 Pierre Laurent-Puig Advisory board and lectures for Sanofi; Honorarium. Advisory board and lectures for Merck Serono; Honorarium. Advisory board and lectures for Amgen; Honorarium. Advisory board and lectures for Roche; Honorarium. 779 Jean-Francois Emile Advisory board and lectures for Merck Serono; Honorarium. 260

321 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 779 Julien Taieb Advisory board and lectures for Sanofi; Honorarium. Advisory board and lectures for Merck Serono; Honorarium. 789 Mari Mino-Kenudson Pathology Consultant for Merrimack Pharmaceuticals; Consultation fee. Pathology Consultant for H3 Biomedicine; Consultation fee. 790 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest. 790 David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 790 Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 805 Dongfeng Tan Consultant for Kingmed diagnostics; I am a consultant. 829 Florian Rieder Advisory, Speaking for AbbVie; Honorarium. Consulting for UCB; Honorarium. 848 Daniel Berney Supervisor of technician for Myriad Genetics, Inc.; Research Grant. Speaker for Sanofi; Honorarium. Speaker for Merck; Honorarium. Speaker for Roche; Honorarium. 848 Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties. 849 Daniel Berney Supervisor of technician for Myriad Genetics, Inc.; Research Grant. Speaker for Sanofi; Honorarium. Speaker for Merck; Honorarium. Speaker for Roche; Honorarium. 858 Daniel Berney Supervisor of technician for Myriad Genetics, Inc.; Research Grant. Speaker for Sanofi; Honorarium. Speaker for Merck; Honorarium. Speaker for Roche; Honorarium. 860 Gaurav Rajoria Molecular Supervisor for Pathline Emerge Pathology Services; Salary. 860 Zach Liu Medical Director for Pathline Emerge Pathology Services; Salary. 860 Szczepan Klimek Molecular Technologist for Pathline Emerge Pathology Services; Salary. 860 Roberto Zoino Laboratory Manager for Pathline Emerge Pathology Services; Salary. 860 Kasra Yousefi Employee of GenomeDx Biosciences. 861 Daniel Berney Supervisor of technician for Myriad Genetics, Inc.; Research Grant. Speaker for Sanofi; Honorarium. Speaker for Merck; Honorarium. Speaker for Roche; Honorarium. 861 Jack Cuzick Contracted Research for Myriad Genetics, Inc.; Research Grant. 882 Daniel Hovelson Speaker for Thermo Fisher Scientific; Travel support. 882 Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support. 889 Alejandro Gru Consultant for Seattle Genetics; Honorarium. 892 Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties. 903 Eric A Klein Speaker for GenomeDx. Speaker for Genomic Health; Honorarium. 908 Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support. 909 Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support. 914 Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties. 919 Jeffry Simko Consultant, Scientific advisory board for 3SCAN; Financial. Consultant for GenomeDx; Travel Expenses. Scientific advisory board for 3D-biopsy; Travel Expenses, financial. Research for Genomic Health; Research funding, Travel expenses. Research for Myriad Genetics; Research Funding. Research for Prostate Cancer Foundation; Travel Expenses. 930 Jonathan Lehrer Employee of GenomeDX; Salary. 261

322 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 930 Mohammed Alshalalfa Employee of GenomeDx; Salary. 930 Ewan A Gibb Employee of GenomeDx; Salary. 930 Beatrix Palmer-Arontsen Employee of GenomeDx Biosciences. 930 Nicholas G Erho Employee of GenomeDx. 930 Elai Davicioni Employee of GenomeDx. 944 Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 944 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 947 Julien Edeline Speaker for BTG; Speaker fee. Consultant for Lilly; Consulting fee. Consultant for Novartis; Consulting fee. 948 Julien Edeline Speaker for BTG; Speaker fee. Consultant for Lilly; Consulting fee. Consultant for Novartis; Consulting fee. 954 Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties. 966 Regan Fulton CEO for Array Science; Salary. 966 Masha Kocherginsky Patent co-inventor of US B2 patent; Royalties. 992 Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 992 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 994 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest. 994 Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Caitlin Connelly Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 994 Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 998 Funmilayo Tade Researcher for Although not impacting this study, funding is or has been received from Blue Earth Diagnostics Ltd. and Nihon Medi-Physics Co., Ltd. through the Emory University Office of Sponsored Projects for other clinical trials using FACBC (fluciclovine); Research funds and Fluciclovine cassettes. 998 Oladunni O Akin-Akintayo Researcher for Although not impacting this study, funding is or has been received from Blue Earth Diagnostics Ltd. and Nihon Medi-Physics Co., Ltd. through the Emory University Office of Sponsored Projects for other clinical trials using FACBC (fluciclovine); Research funds and Fluciclovine cassettes. 998 Mark M Goodman for I am entitled to a royalty derived from the sale of products related to the research described in this abstract. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict of interest policies. 998 David M Schuster Researcher for Although not impacting this study, funding is or has been received from Blue Earth Diagnostics Ltd. and Nihon Medi-Physics Co., Ltd. through the Emory University Office of Sponsored Projects for other clinical trials using FACBC (fluciclovine); Research funds and Fluciclovine cassettes Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Caitlin Connelly Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 262

323 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 1015 Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alex Forrest-Hay Salary for Thermo Fisher Scientific, Affymetrix; Financial relationships Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties Yifei Zhu Employee of Spring Bioscience; Salary Daniel Berney Supervisor of technician for Myriad Genetics, Inc.; Research Grant. Speaker for Sanofi; Honorarium. Speaker for Merck; Honorarium. Speaker for Roche; Honorarium Rajal B Shah Employee of Miraca Life Sciences; Salary Jiyoon Yoon Employee of Miraca Life Sciences; Salary Steven C Smith Author of Amirsys/Elsevier Publishing; Royalties Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support Mohammed Alshalalfa Employee of GenomeDx; Salary Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support Nicholas G Erho Employee of GenomeDx Ewan A Gibb Employee of GenomeDx; Salary Jijumon Chelliserry Employee of GenomeDx; Salary Lony Lim Employee of GenomeDx; Salary Lucia LC Lam Employee of GenomeDx; Salary Elai Davicioni Employee of GenomeDx Kasra Yousefi Employee of GenomeDx Biosciences Regan Fulton CEO for Array Science; Salary Masha Kocherginsky Patent co-inventor of US B2 patent; Royalties Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support Scott A Tomlins Speaker for Thermo Fisher Scientific; Travel Support. Consultant and co-founder of Strata Oncology; Equity and Honorarium. Consultation for Astellas, Ventana, AbbVie, Janssen; Honorarium. Sponsored Research for Astellas, GenomeDX; Grant support Zaid Haddad Employee of GenomeDx Mandeep Takhar Employee of GenomeDx Biosciences Kasra Yousefi Employee of GenomeDx Biosciences Nicholas G Erho Employee of GenomeDx Beatrix Palmer-Arontsen Employee of GenomeDx Biosciences Elai Davicioni Employee of GenomeDx Eric A Klein Speaker for GenomeDx. Speaker for Genomic Health; Honorarium Frederique Penault-Llorca Consultant and Speaker for Roche; Honorarium et Research Grants. Consultant and Speaker for Merck; Honorarium William Catherino Consultant for Allergan plc; Consulting Fees. Consultant for Bayer; Consulting Fees Carol Eisenhut Employee of DCL Pathology LLC; Salary. 263

324 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 1121 Rick Blakesley Employee of Allergan plc; Salary Anna Chan Employee of Allergan plc; Salary Vilma Sniukiene Employee of Allergan plc; Salary Steven Goldstein Member of GYN Advisory board for Allergan plc, AbbVie, Radius Health, Pfizer, Shionogi JDS Therapeutics, Therapeutics MD, Sermonix, and Azure Biotech; Consulting Fees. Consultant for Cooper Surgical, Cook OBGYN, and Philips Ultrasound; Consulting Fees. Member of speakers bureau for Pfizer and Shionogi JDS Therapeutics; Speaker Fees Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Michael E Goldberg Employee of Foundation Medicine; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Carol Aghajanian Steering Committee Meeting for OxiGene; Honorarium Anne Mills Trial participation for Philips Digital Pathology; Salary support Rajyasree Emmadi Investor for Cepheid; Own common stock (less than 10k) Josh Haimes Employee of ArcherDX, Inc.; Salary. Employee of ArcherDX, Inc.; Stocks Brian Kudlow Employee of ArcherDX, Inc.; Salary Mark H Stoler Speaker, expert pathologist for Merck; Honorarium. Speaker, expert pathologist for Hologic/Gen-Probe; Honorarium. Speaker, expert pathologist for Ventana Medical Systems; Honorarium. Speaker, expert pathologist for Becton Dickinson; Honorarium. Speaker, expert pathologist for Roche; Honorarium Anne Mills Trial participation for Philips Digital Pathology; Salary support Mark H Stoler Speaker, expert pathologist for Merck; Honorarium. Speaker, expert pathologist for Hologic/Gen-Probe; Honorarium. Speaker, expert pathologist for Ventana Medical Systems; Honorarium. Speaker, expert pathologist for Becton Dickinson; Honorarium. Speaker, expert pathologist for Roche; Honorarium Anne Mills Trial participation for Philips Digital Pathology; Salary support Anne Mills Trial participation for Philips Digital Pathology; Salary support Anne Mills Trial participation for Philips Digital Pathology; Salary support Torsten Nielsen Breast cancer test licensing for Nanostring; Royalties Anne Mills Trial participation for Philips Digital Pathology; Salary support Vikram Deshpande Research support for Affymetrix; Research support to institution Peter Illei Pathology Advisory board for Roche; Honorarium. Educational Webinar for Ventana; Honorarium Anne Mills Trial participation for Philips Digital Pathology; Salary support Stacey E Mills Trial participation for Philips Digital Pathology; Salary support Josh Haimes Employee of ArcherDX, Inc.; Salary. Employee of ArcherDX, Inc.; Stocks Brian Kudlow Employee of ArcherDX, Inc.; Salary Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Kai Wang Employee of Foundation Medicine, Inc.; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Brian P Rubin PI for Philips; Research Grant Anant Madabhushi Equity holder for Elucid Bioimaging; Equity holder. Scientific advisory Consultant for Inspirata Inc.; Equity holder Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 264

325 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 1331 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Kai Wang Employee of Foundation Medicine, Inc.; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vikram Deshpande Research support for Affymetrix; Research support to institution Tracy George PI for Allakos; Research grant. Consultant for Blueprint Medicine; Honoraria. Consultant for Novartis; Honoraria. Consultant for Celgene; Honoraria Mohamed Salama Advisory / Speaker for Seatle genetics; Honorarium Jason Gotlib Principle Investigator for Novartis; Funding Tracy George PI for Allakos; Research grant. Consultant for Blueprint Medicine; Honoraria. Consultant for Novartis; Honoraria. Consultant for Celgene; Honoraria Mohamed Salama Advisory / Speaker for Seatle genetics; Honorarium Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jason Gotlib Principle Investigator for Novartis; Funding Tracy George PI for Allakos; Research grant. Consultant for Blueprint Medicine; Honoraria. Consultant for Novartis; Honoraria. Consultant for Celgene; Honoraria Mina L Xu Educational Speaker (non-branded) for Seattle Genetics; Honorarium Weina Chen Scientific advisory board for Stemline Richard SP Huang Staff pathologist for Roche Tissue Diagnostics; Salary Ryan Emerson Full-time Employment of Adaptive Biotechnologies Corporation; Salary and Equity Marissa Vignali Employee of Adaptive Biotechnologies; Employment and Equity Ilan Kirsch Employee of Adaptive Biotechnologies; Employment Robert D Daber Employee of BioReference Laboratories; Salary Jason Gotlib Principle Investigator for Novartis; Funding Jason Gotlib Principle Investigator for Novartis; Funding Arthur Frankel Scientific advisory board for Stemline Therapeutics; Royalty, Stock Robert D Daber Employee of BioReference Laboratories; Salary Tracy George PI for Allakos; Research grant. Consultant for Blueprint Medicine; Honoraria. Consultant for Novartis; Honoraria. Consultant for Celgene; Honoraria Mohamed Salama Advisory / Speaker for Seatle genetics; Honorarium Kit Fuhrman Employee of Nanostring Technologies, Inc.; Salary Sheila E Crowe Author of topics on H. pylori infection for UpToDate; Honorarium. Author of a book Celiac Disease for Dummies for John Wiley & Sons Ltd; Royalties. AGA president-elect for American Gastroenterology Association; Honorarium. member for American of Internal Medicine - Gastroenterology Examination ; Honorarium Michael Bonert Founder / owner of Libre Pathology Limited; No finanical benefit. Company runs librepathology.org - an open access creative commons licensed pathology wiki - without commercial sponsorship or advertisements Michael Feldman Consultant and SAB for Philips Healthcare; Money. Consultant and SAB for Inspirata Inc; Money and stock options Brian P Rubin PI for Philips; Research Grant Christopher A Moskaluk Trial participation for Philips Digital Pathology; Salary support Mischa Nelis Employee of Philips healthcare; Salary Anthony Iafrate Licensing of technology for ArcherDx; Equity and royalties Michael Feldman Consultant, SAB for Philips healthcare; Money. Consultant, SAB for Inspirata; Money Satish Viswanath Advisory board member for Virbio, Inc.; Equity Anant Madabhushi Equity holder for Elucid Bioimaging; Equity holder. Scientific advisory Consultant for Inspirata Inc.; Equity holder. 265

326 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 1607 Anant Madabhushi Equity holder for Elucid Bioimaging; Equity holder. Scientific advisory Consultant for Inspirata Inc.; Equity holder Philip Halloran Founder of TSI; Stocks Anthony Chang Speaker for Alexion Pharmaceuticals; Honorarium Anthony Chang Speaker for Alexion Pharmaceuticals; Honorarium Anthony Chang Speaker for Alexion Pharmaceuticals; Honorarium J Charles Jennette Unbranded Speaker for Genentech; Fees. Consultant for GSK; Fee. Speakre, Consultant for AbbVie; Honorarium. Consultant for ChemoCentryx; Fee Alton B Farris Research for MedImmune; Salary support. Research for Resonance Health; Salary support Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shauna Levinson Employee of Affymetrix, part of Thermo Fisher Scientific; Salary, Stocks Manoj Gandhi Employee of Affmetrix part of Thermo Fisher Scientific; Salary, Stocks Manoj Gandhi Employee of Affmetrix part of Thermo Fisher Scientific; Salary, Stocks Shauna Levinson Employee of Affymetrix, part of Thermo Fisher Scientific; Salary, Stocks Vikram Deshpande Research support for Affymetrix; Research support to institution Xiao-Jun Ma Employee of Advanced Cell Diagnostics; Salary Sharon Presnell Employee of Samsara Sciences; Salary Ken Dorko Employee of Samsara Sciences; Salary Shauna Levinson Employee of Affymetrix, part of Thermo Fisher Scientific; Salary, Stocks Manoj Gandhi Employee of Affmetrix part of Thermo Fisher Scientific; Salary, Stocks Janis M Taube Advisory board for Bristol Myers Squibb; Honorarium. Advisory board for Merck; Honorarium. Advisory board for Astra Zeneca; Honorarium. Investigator-initated Research for Bristol Myers Squibb; Research Funding Dongfeng Tan Consultant for Kingmed diagnostics; I am a consultant Yuri Nikiforov Consultant for Quest Diagnostics; Consulting fee. for Commercial contract between UPMC and CBLPATH, Inc Ashley P Ghiaseddin Advisory committee for Optune; Honorarium Ralph H Hruban PALB2 Invention for Myriad Genetics; Royalty Payments Julien Edeline Speaker for BTG; Speaker fee. Consultant for Lilly; Consulting fee. Consultant for Novartis; Consulting fee Benjamin Kipp Co-Investigator for Abbott Molecular; Grant Support Emily Barr Fritcher Co-Inventor of Abbott Molecular; Potential to receive royalties on FISH probes used to detect pancreatobiliary tract malignancy Mamoun Younes President for Olive Tree Media LLC; Shares Pamela S Younes My husband has shares for Olive Tree Media, LLC; My husband has shares Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest. 266

327 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 1855 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Anant Madabhushi Equity holder for Elucid Bioimaging; Equity holder. Scientific advisory Consultant for Inspirata Inc.; Equity holder Anne Mills Trial participation for Philips Digital Pathology; Salary support Adrienne Johnson Employee of Foundation Medicine, Inc; Equity and employment Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti Ramkissoon Employee of Foundation Medicine, Inc.; Employment, Equity Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium Alice L Gray Scientific Advisory board member for Gilead; Consulting Fee Carolina A Souza Consultant for Boehringer Ingelheim; Consulting fee. Consultant for Pfizer; Consulting fee Marcio M Gomes Course director for Pfizer, Eli Lilly, AstraZeneca, Hoffmann-La Roche, Boehringer- Ingelheim, Brystol Myers-Squibb; Unrestricted educational grants. Consultant; course director for Merck; Consulting fees; unrestricted educational grants David Tacha Chief scientific officer for Biocare LLC; Salary and stockholder Darren Freed Management for Tevosol, Inc; Stock/ownership Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium Marc Judson Consultant for Biogen; Consulting fees. Study PI for Mallinckrodt; Grant to institution. Study PI for Foundation for Sarcoidosis Research; Grant to institution Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Michael E Goldberg Employee of Foundation Medicine; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti H Ramkissoon Employee of Foundation Medicine; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Hong All sponsors with c-met inhibitors for Amgen; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for EMD Serano; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for Pfizer; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for Lilly; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for Mirati; All sponsors with c-met inhibitors Garrett Frampton Employee of Foundation Medicine, Inc.; Employment/Equity Interest Anika Gupta Intern for Foundation Medicine, Inc.; Employment Caitlin Connelly Employee of Foundation Medicine, Inc.; Employment/Equity Interest David Fabrizio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Alexa Schrock Employee of Foundation Medicine, Inc.; Employment/Equity Interest Laurie M Gay Employee of Foundation Medicine, Inc.; Employment/Equity Interest Shakti Ramkissoon Employee of Foundation Medicine, Inc.; Employment, Equity. 267

328 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 1924 Julia A Elvin Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jo-Anne Vergilio Employee of Foundation Medicine, Inc.; Employment/Equity Interest Siraj M Ali Employee of Foundation Medicine, Inc.; Employment/Equity Interest Vincent Miller Employee of Foundation Medicine, Inc.; Employment/Equity Interest Philip Stephens Employee of Foundation Medicine, Inc.; Employment/Equity Interest Jeffrey Ross Employee of Foundation Medicine, Inc.; Employment/Equity Interest James Suh Employee of Foundation Medicine, Inc.; Employment/Equity Interest Adrian Sacher Speaker for Genentech-Roche; Travel funding Jeff Kim Employee of Advanced Cell Diagnostics; Salary Xiao-Ming Mindy Wang Employee of Advanced Cell Diagnostics; Salary Nan Su Employee of Advanced Cell Diagnostics; Salary Rob Monroe Employee of Advanced Cell Diagnostics; Salary Xiao-Jun Ma Employee of Advanced Cell Diagnostics; Salary Emily Park Employee of Advanced Cell Diagnostics; Salary Peter Illei Pathology Advisory board for Roche; Honorarium. Educational Webinar for Ventana; Honorarium Rupert Langer Speaker for Roche; Honorarium. Attendant for Roche; Sponsored Training. Speaker for MSD; Honorarium. Advisory board for MSD; Honorarium. Advisory board for BMS; Honorarium Sabina Berezowska advisory committee for BMS; Honorarium. advisory committee for MSD; Honorarium. advisory committee for Roche; Speaker fee. Industry sponsored training for MSD; Grant. Industry sponsored training for Roche; Honorarium Mari Mino-Kenudson Pathology Consultant for Merrimack Pharmaceuticals; Consultation fee. Pathology Consultant for H3 Biomedicine; Consultation fee Adrian Sacher Speaker for Genentech-Roche; Travel funding Mari Mino-Kenudson Pathology Consultant for Merrimack Pharmaceuticals; Consultation fee. Pathology Consultant for H3 Biomedicine; Consultation fee Yesim Gokmen-Polar Founder of SysGenomics; Founder Shares Sunil Badve Founder of SysGenomics; Founder Shares Peter Illei Pathology Advisory board for Roche; Honorarium. Educational Webinar for Ventana; Honorarium David Hwang Advisory Committee meeting for Pfizer; Consulting Fee. Speaker for Boehringer Ingelheim; Honorarium. Other activitiy (training) for Merck; Honorarium Wijendra Senarathne Employee of Caris Life Sciences; Salary Peggy Gates Employee of Caris Life Sciences; Salary Semir Vranic Consultant for Caris Life Sciences; Honorarium Zoran Gatalica Employee of Caris Life Sciences; Salary Mari Mino-Kenudson Pathology Consultant for Merrimack Pharmaceuticals; Consultation fee. Pathology Consultant for H3 Biomedicine; Consultation fee Mari Mino-Kenudson Pathology Consultant for Merrimack Pharmaceuticals; Consultation fee. Pathology Consultant for H3 Biomedicine; Consultation fee Ruth L Katz Researcher for Cynvenio Inc.; Sponsored research agreement Janis M Taube Advisory board for Bristol Myers Squibb; Honorarium. Advisory board for Merck; Honorarium. Advisory board for Astra Zeneca; Honorarium. Investigator-initated Research for Bristol Myers Squibb; Research Funding Benjamin Kipp Co-Investigator for Abbott Molecular; Grant Support Justin F Gainor Consultant for Merck; Consultation fee. Consultant for Bristol-Myers Squibb; Consultation fee. Consultant for Genentech; Consultation fee. Consultant for Jounce; Consultation fee. Consultant for Kyowa Hakko Kirin; Consultation fee. Consultant for Incyte; Consultation fee Mari Mino-Kenudson Pathology Consultant for Merrimack Pharmaceuticals; Consultation fee. Pathology Consultant for H3 Biomedicine; Consultation fee Scott Crawford Chief Technical Officer for Array Science; Salary Alyicia Rios Senior Product Manager for Sakura Finetek; Salary Farah Patell-Socha Product Development Manager for Horizon Discovery, Ltd.; Salary Regan Fulton CEO for Array Science; Salary Vikram Deshpande Research support for Affymetrix; Research support to institution Marjorie P David Inventor of UAMS Patent and Copyright Committee; Provisional Patent Shawn LeDoux Inventor of UAMS Patent and Copyright Committee; Provisional Patent. 268

329 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 2040 David Hong All sponsors with c-met inhibitors for Amgen; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for EMD Serano; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for Pfizer; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for Lilly; All sponsors with c-met inhibitors. All sponsors with c-met inhibitors for Mirati; All sponsors with c-met inhibitors Jan A Nowak Employment of OmniSeq, LLC, Buffalo, NY; Ownership Jan A Nowak Employment of OmniSeq, LLC, Buffalo, NY; Ownership David Altree-Tacha Employee of Biocare Medical; Salary and Stock Wei Yuan Employee of Biocare Medical; Salary George Yang Pathologist/Employee of Biocare Medical; Salary Oleg A Andreev Co-Founder of PHLIP, Inc Yana K Reshetnyak Co-Founder of phlip Co.; Financial relationship (owner) Michael Barnes Employee of Roche; Employee Isaac Bai Employee of Roche; Employee Kien Nguyen Employee of Roche; Employee Joerg Bredno Employee of Roche; Employee Rachel Fonstad Employee of Roche; Employee Suresh Agarwal Employee of Roche; Employee Suhas Patil Employee of Roche; Employee Bharathi Vennapusa Employee of Roche; Employee June Clements Employee of Roche; Employee Carol Jones Employee of Roche; Employee Sutini Ngadiman Employee of Roche; Employee Azita Djalilvand Employee of Roche; Employee Tracie Gardner Employee of Roche; Employee Charles Bechert Employee of Roche; Employee Christoph Guetter Employee of Roche; Employee Xiao-Ming Mindy Wang Employee of Advanced Cell Diagnostics; Salary Nan Su Employee of Advanced Cell Diagnostics; Salary Emily Park Employee of Advanced Cell Diagnostics; Salary Xiao-Jun Ma Employee of Advanced Cell Diagnostics; Salary Brady P Culver Employment of ArcherDX, Inc.; Full time paid employee Jerome E Lee Employment of ArcherDX, Inc.; Full time paid employee Josh Haimes Employee of ArcherDX, Inc.; Salary. Employee of ArcherDX, Inc.; Stocks Namitha Manoj Employment of ArcherDX, Inc.; Full time paid employee Eric M Davis Employment of ArcherDX, Inc.; Full time paid employee Ian McKittrick Employment of ArcherDX, Inc.; Full time paid employee Katelyn E Trifilo Employment of ArcherDX, Inc.; Full time paid employee Laura A Johnson Employment of ArcherDX, Inc.; Full time paid employee Laura Griffin Employment of ArcherDX, Inc.; Full time paid employee Brian Kudlow Employee of ArcherDX, Inc.; Salary Jens Eberlein Employment of ArcherDX, Inc.; Salary Thomas Harrison Employment of ArcherDX, Inc.; Salary Ian McKittrick Employment of ArcherDX, Inc.; Full time paid employee Megan Wemmer Employment of ArcherDX, Inc.; Salary Laura Griffin Employment of ArcherDX, Inc.; Full time paid employee Brady P Culver Employment of ArcherDX, Inc.; Full time paid employee Laura A Johnson Employment of ArcherDX, Inc.; Full time paid employee Brian Kudlow Employee of ArcherDX, Inc.; Salary Frédéric Leblond Co-Founder of ODS Medical; Co-founder Zhiqing Zhang Company Employee of Novodiax, Inc Shuo Chen Company Employee of Novodiax, Inc Angelina Motiee Company Employee of Novodiax, Inc Yonghua Zhang Company Employee of Novodiax, Inc Songqing Zhao Company Employee of Novodiax, Inc Jianfu Wang CEO for Novodiax, Inc Julie Y Tse Employee of KEW, Inc; Employee Cheryl L Eifert Employee of KEW, Inc; Employee Alfonso Heras Employee of Bio SB, Inc; Salary Chase V Furler P/T Employee of Bio SB, INC; Salary Carolyn M Wall Employee of Bio SB, INC; Salary. 269

330 DISCLOSURE INFORMATION Abstract Name Relevant Disclosure Information 2134 Nicole Massoll Consultant for Rosetta Genomics; Honorarium Anne Mills Trial participation for Philips Digital Pathology; Salary support Christopher A Moskaluk Trial participation for Philips Digital Pathology; Salary support Rebecca Blackwell Trial participation for Philips Digital Pathology; Salary support James W Mandell Trial participation for Philips Digital Pathology; Salary support Stacey E Mills Trial participation for Philips Digital Pathology; Salary support Helen P Cathro Trial participation for Philips Digital Pathology; Salary support Kenneth Margulies Researcher for Thoratec Corporation; Research Grant. Researcher for Merck; Research Grant Michael Feldman Consultant, SAB for Philips healthcare; Money. Consultant, SAB for Inspirata; Money Anant Madabhushi Equity holder for Elucid Bioimaging; Equity holder. Scientific advisory Consultant for Inspirata Inc.; Equity holder Frédéric Leblond Co-Founder of ODS Medical; Co-founder Jianfu Wang Abstract Author of Novodiax; Enployee Yonghua Zhang Company Employee of Novodiax, Inc Zhiqing Zhang Company Employee of Novodiax, Inc Angelina Motiee Company Employee of Novodiax, Inc Jeff Kim Employee of Advanced Cell Diagnostics; Salary Nan Su Employee of Advanced Cell Diagnostics; Salary Emily Park Employee of Advanced Cell Diagnostics; Salary Xiao-Jun Ma Employee of Advanced Cell Diagnostics; Salary Axel Wellmann Consultant for Bruker; Honorarium Tobias Boskamp Consultant for SCILS; Honorarium Dongfeng Tan Consultant for Kingmed diagnostics; I am a consultant Christine E Sheehan Consultant for Foundation Medicine, Inc.; Honorarium. 270

331 INDEX #IAMUSCAP #USCAP2017

332 THE USCAP HEADSHOT LOUNGE Get your headshot taken by our professional photographers at the Annual Meeting. This service will be complimentary for members and only $50 for non-members. Stop by CC 224 any time during the coffee breaks on March 5-8 (excluding Tuesday afternoon, March 7) to take advantage of this opportunity.

333 INDEX A Abbott, Daniel W ,142,254 Abbott, Sara Abbruzzese, Mark Abdel-Aal, Wafaa E Abdelal, Heba A Abdelkader, Amrou ,199,254 Abdelmalek, Manal Abdi, Jahangir Abdul-Karim, Fadi...69 Abdulfatah, Eman ,125, ,195 Abdulkareem, Fatimah B Abdulla, Farah Abdulrahman, Ahmed A Abdulsattar, Jehan A Abedalthagafi, Malak Abedi-Ardekani, Behnoush , 212 Abel, E Jason Abel, Gyorgy Abel, Haley Abendroth, Catherine S Aberman, Zachary Abeykoon, Jithma Abida, Wassim Aboelnazar, Nader Abouelfadl, Dalia Aboukameel, Amro Abraham, Susan ,220 Abraira, Laura Abramson, Vandana Abrial, Catherine Abro, Schuharazad Abu-Farsakh, Sohaib Abu-Sheasha, Ghada Abugharib, Ahmed E Abulsayen, Hend ,214, ,252 Abuzenadah, Adel Accola, Molly ,114,172 Ackerman, Michael J Acosta, Andres ,224 Acree, Rachel Adam-Granger, Eloise Adam, Benjamin ,151 Adams, Emily M Adams, Kristen Adams, Scott Adams, Thomas A Adebayo, Luqman Adelaja, Oluwatobi Adem, Patricia Adeniran, Adebowale...116, ,239 Adesina, Adekunle...41 Adeyinka, Adewale Aditya, Bardia Adowanka, Aisha N Adsay, N. Volkan...22,24,...26,27,28,29,92,99,105, 130,...142,143,165,172,174,...175,191,200, 220,254,255 Aejaz, Nasir Aesif, Scott W ,188 Afify, Alaa Afkhami, Michelle Agaimy, Abbas ,151, ,202 Agander, Tina K Agaram, Narasimhan P Agarwal, Archana M Agarwal, Indu Agarwal, Jai Prakash Agarwal, Nitin K Agarwal, Shweta Agarwal, Suresh Agboola, AOJ Aggarwal, Nidhi ,205 Agoff, Nicholas Agosto-Arroyo, Emmanuel Agoston, Agoston Agrawal, Neha Agrawal, Tanupriya Agro, Evangeline Aguilar-Jakthong, Josephine S Aguiluz, Angela Agulnik, Jason Ahan, Ayse Ahlquist, David A Ahlstedt, Jeffrey ,217 Ahmad, Amar Ahmad, Farhan Ahmed, Atif Ahmed, Faris Ahmed, Ishtiaque Ahmed, Shahida Ahn, Sangtae ,133 Ahn, Soomin Ahram, Mamoun Ahsanuddin, Arshad Ai, Di , 215 Aijaz, Namrah Ailles, Laurie Ainechi, Sanaz...123,129,131,133 Aird, John Akakpo, Patrick K Akazawa, Yuko ,159 Akhtar, Israh ,240 Akhter, Shabnam Akin-Akintayo, Oladunni O Akinde, Olakanmi R Akki, Ashwin Aksentijevich, Ivona Al-Ahmadie, Hikmat ,123,...133,175,176,188,201,257 Al-Ahwal, Mahmoud S Al-Antary, Noor Al-Awar, Shamsa Al-Bozom, Issam Al-Ghamdi, Fahad Al-Ghamdi, Yahya Al-Ibraheemi, Alyaa ,197,235 Al-Kawaaz, Mustafa Al-Khinji, Aisha Al-lbraheemi, Alyaa Al-Maghrabi, Basim J ,224 Al-Maghrabi, Jaudah A...184, ,224 Al-Moustafa, Ala-Eddin Al-Obaidy, Khaleel I ,179 Al-Qahtani, Mohammed H...184, Al-Qurayshi, Zaid Al-Rohil, Rami...71,191 Al-Turkmani, MRabie Al-Zaid, Tariq ,197 Alaghehbandan, Reza ,203 Alatassi, Houda , 241,245 Alattia, Lubna A ,234 Alava, Enrique de Albadine, Roula Albain, Kathy S Albanese, Christopher Albanese, Joseph ,207 Albarracin, Constance T ,212 Albawardi, Alia Alberts, Steven R Albustanji, Amani Alcasid, Matthew Aldayel, Fouad Aldecoa, Iban...132,153,214,245 Alekseev, Boris Alex, Deepu ,221 Alexander, Erik K Alexander, Mariam P...51, 74, 136,182,254 Alexander, Melissa Alexander, Rhonda Alexandrescu, Sanda ,185 Alexiev, Borislav Alexis, John Alghamdi, Mohammed A.212,241 Alholle, Abdullah Ali-Fehmi, Rouba ,125, ,195 Ali, Siraj M ,114, ,123,126,129,150,172,177,18...7,191,192,193,231 Ali, Syed Z... 44, 116,117,239 Alkan, Serhan Alkhader, Ali Alkhasawneh, Ahmad Allan, John Allard, Michael F...26 Allen, Carl...60 Allen, M B Allen, Peter Allen, Richard A Allen, Timothy Craig...45 Allende, Daniela ,121,...142,143,173,229 Allgaeuer, Michael Allison, Derek ,130,240 Allison, Kimberly H , 137,216 Almardini, Nour Almarzooqi, Saeeda SH Almekinders, Mathilde Almenara, Jorge A ,231 Almutairi, Fawaz Alnajar, Hussein ,186 Alobeid, Bachir ,253 Alos, Lucia Alos, Silvia Alosh, Baraa ,179,195 Alpers, Charles E Alpert, Lindsay... 40,109,167,173,220 Alqassab, Usama Alqatari, Mahfood Alrajjal, Ahmed Alruwaii, Fatimah I ,201 Alsadi, Alaa Alshalalfa, Mohammed Alsolami, Afaf Altiok, Soner ,210 Altorki, Nasser K Altree-Tacha, David Alva, Ajjai ,176 Alvarado-Cabrero, Isabel...150, , 221,250 Alves, Venancio...50 Amacher, Anne Marie O Amador, Lucia Amano, Atsushi Amaya, Clarissa N Ambaye, Abiy ,220 Ambelil, Manju Ambrosone, Christine B Amemiya, Yutaka ,216,225 Ameri, Maryam D Amin, Ali Amin, Hebatallah A Amin, Khalid ,157,...164,165,217,218 Amin, Mahul B...46, 105,...124,133,202,222 Amin, Said M Amini, Behrang Amini, Elham Amrollahi, Fatemeh An, Soyeon Anandan, Vasuki Ananthanarayanan, Vijayalakshmi ,186,209 Andea, Aleodor A...22, 23,... 65, 90, 95 Andeen, Nicole ,201 Anders, Robert A...56, 83, ,166,229 Anderson, Blake B ,146 Anderson, Joshua Anderson, Kevin Anderson, Matthew ,249 Anderson, Michele Anderson, Neil Anderson, Scott Andion, Maitane Andrade, Mariza de Andrade, Priscila Andrade, Rafael E Andras, Kapus Andre, Saudade ,240 Andreasen, Simon ,150,197 Andreoli, Steven Andreopoulou, Eleni ,196 Andres, Maria del Mar Andresen, Kevin Andreu, Xavier Andrici, Juliana Andrulis, Irene ,116,216 Aneja, Amandeep Angeletti, Cesar Angelova, Evgeniya A Angot, Émilie Anichini, Andrea Anis, Shady E Annan, Anand C ,139,158 Annunziata, Joseph F...159, ,212,238 Ansari, Junaid Ansari, Mohammad Q Ansell, Stephen M Ansell, Wendy Anthony, Douglas Antic, Tatjana ,117, ,143,176,180,201,240,247 Antonescu, Cristina R...26, 68, ,136,165,166,188,194,236 Ao, Minghui

334 INDEX Aoki, Ichiro Aoun, Patricia A Appelman, Henry D ,220 Apple, Sophia April, William Aqil, Barina Arab, Seyedeh Elham Arana, Iñigo Aranake-Chrisinger, John Aranda, F I Araujo, Karina S ,203,246 Araya, Camila B Araya, Juan Carlos ,191,255 Arber, Daniel A...22, 91, 99,...151,153,162,206 Arcaro, Kathleen Arciero, Cletus Arcila, Maria E , 112,133, ,192,193 Aretini, Paolo Argani, Pedram ,122, ,168 Argenyi, Zsolt B Argyris, Prokopios Arispe, Karen Ariza, Aurelio Armanious, Hanan ,255 Armengol, Carolina Armenia, Joshua Armylagos, Donna ,141 Arnam, John Van ,186 Arnason, Thomas Arnold, Christina A ,121,...172,200,214, 257 Arnold, Michael A ,214 Arnold, Rebecca Arnould, Laurent Aron, Manju Arora, Kshitij S...121,200,219,225 Arora, Samriti ,235 Arora, Taranjit K Arpin, Ronald ,117 Arrossi, Andrea V Arthur, Gaba Arun, Indu Arva, Nicoleta Asa, Sylvia L...26, 138 Asada, Yujiro Asaka, Shiho ,187 Asamura, Hisao Asato, Marcel A ,203,246 Ascani, Stefano Asch-Kendrick, Rebecca ,168 Ashford, Bruce ,137 Ashi, Shaymaa AL-L Ashikaga, Takamaru Ashman, Dayne Ashraf, Nabil ,205,231 Asiry, Saeed Askan, Gokce Askari, Reza Askin, Frederic Asleh-Aburaya, Karama Assaad, Adel Assarzadegan, Naziheh Assidi, Mourad Assylbekova, Binara ,125, ,237 Astigarraga, Itziar Astles, J R ,157 Astvatsaturyan, Kristine Aswad, Bassam ,186 Atenafu, Eshetu G ,207,227 Athanazio, Daniel ,202 Atieh, Mohammad Atkins, KristenA...27, 115,124,180 Atkinson, James Atsaves, Vasillios Atta, Mohamed Adel Attanoos, Richard...45 Attiyeh, Marc Aubert, Sebastien Aubry, Marie-Christine...105, 156, , 230 Aucejo, Federico Auerbach, Aaron Auger, Cristina Aung, Kimberly Aung, Kyaw Aung, Phyu P... 71, 118,186, ,208,241 Aust, Charles H Autio, Karen A Avadhani, Vaidehi ,143, ,173 Aviel-Ronen, Sarit ,250 Avkshtol, Valentina ,195 Avogbe, Patrice H Avril, Stefanie Aw, Sze Jet Awadallah, Amad ,210,218 Awasthi, Namrata P Axiotis, Constantine A Ayala, Alberto ,170,235 Ayangbesan, Abimbola Ayers, Leona W Aynardi, Jason Azad, Azar Azar, Azniv Azevedo, Livia LA ,203,246 Azkargorta, Mikel Azmi, Asfar Azorín, Daniel Azria, David Azzato, Elizabeth B Babaoglu, Berrin Buyukeren Babu, K M Babushok, Daria Bacani, Julinor Badmos, Kabir Badri, Osamah AL Badrinarain, Jason Badve, Sunil...100,156,195,215 Bae, Hyunsik ,221,244 Bae, Ja Seong Bae, Young Kyung Baecklund, Eva Baeesa, Saleh Baergen, Rebecca Bagg, Adam...24,27,152,153,206 Baglieri, Jacopo Bahar, Burak Bahirwade, Ganesh Bahler, David W , 257 Bahmanyar, Mohammad Bahrami, Armita ,241 Bai, Isaac...58 Bai, Shi ,226 Bailey, Jennifer M Bailey, Mark A Bailey, Nathaniel Baine, Marina K ,248 Bajaj, Mandeep S Bajorin, Dean F ,175 Bajpai, Jyoti Baker, Gabrielle Baker, Jeryl Baker, Thomas P...49 Baker, Tiffany Bakhshi, Sameer Bal, Munita...130,150,204,205 Balagué, Olga ,252 Balaguer, Francesc ,245 Balakrishna, Jayalakshmi P Balassanian, Ronald Balatico, Michael A Balci, Serdar ,172,220 Baldaia, Helena Baldion, Ana Margarita Bale, Tejus A Balis, Ul Balis, Ulysses...42 Balk, Steven P ,223 Balla, Andre Ballard, Morgan Ballen, Karen Ballentine, Samuel J Ballester, Hortensia Ballester, Leomar Ballinger, Lori Baloch, Zubair W... 44, 138, 164 Balogh, Zsofia Baltaro, Richard J Baltatzis, George E Baltay, Michele T ,211, 227 Balzer, Bonnie ,198 Banach, Bridget S Bandoh, Shuji Bandy, Andrew Bandyopadhyay, Sudeshna...110, ,179,195 Banerjee, Anjishnu ,122 Banerji, Nilanjana Banet, Natalie Bang, Heejin Bangash, Mohammed Bangs, Charles D Bangs, Dana Baniak, Nick Banizs, Anna...159,205,212,238 Banjo, Adekumbiola Banks, Peter ,115,140 Banks, Roz Banky, Sandra Bann, Darrin ,171 Bantz, Christopher Baraban, Ezra Barahona, Marc Baral, Reetu Baras, Alexander ,177,247 Baratta, Paul Barbieri, Andreia ,235 Barbuto, Denise Bárcena, Carmen Barisoni, Laura...74 Barkan, Güliz A , 109, , 119, 123, 177, 217, 238, 257 Barker, Heather S Barkoh, Bedia A Barletta, Justine A...23, 91, ,172, 257 Barlogie, Bart Barna, Nicholas Barnard, Nicola Barnes, Leon...58 Barnes, Michael Barnhill, Raymond Barrera-Herrera, Luis E Barreto, Jose Barrett, Amanda Barretta, Francesco Barrows, Brad D , 230 Barry-Holson, Keegan Barry, Marc Barsan, Iulia ,250 Bartlett, Nancy Barua, Ashim R Baselga, Jose Basha, Basma Bashir, Samir Al Bashleben, Christine Bashover, Eva M Bassat, Quique Bassett, Roland , 240 Bassiouny, Dina Basso, Cristina Bastacky, Sheldon Bastos, Lucas QA ,203,246 Basturk, Olca... 99,130,257 Bates, Michael Batts, Kenneth...73 Baudhuin, Linnea M Baudin, Eric Baum, Jordan E ,210 Baumgartner, Joel M Baunoch, David Baus, Rebecca Bautista, Pinky Bavi, Prashant ,219 Bawab, Ramzi Bayat, Sahar ,247 Bayol, Beryl Bean, Gregory R , 215, 225 Beaubier, Nike T ,211,219 Beca, Francisco Bechert, Charles Beltran, Luis ,223 Ben-Gasheer, Mohammad Benasalah, Karim ,247 Benayed, Ryma ,192 Bendall, Sean Benedetti, Ines Benini, Stefania Bennett, Ana E Bennett, Jennifer ,179 Bensalah, Karim Berezowska, Sabina Berg, Aaron N Berger, David Berger, Michael F ,150,175 Bergeron, Anne Bergfeld, Wilma F Bergstrom, Colin Bergum, Christopher Berman, David ,196 Berman, Samuel H Bernardini, Marcus ,250 Bernardo, Margarita Bernatsky, Sasha

335 INDEX Berney, Daniel M , 146, 202, , 223, 257 Bernhard, Jean-Christophe ,247 Berni, Silvia Bernicker, Eric ,188 Bernieh, Anas ,252 Berrocal, Julian Bertherat, Jerome Bertolotti, Alessia Bertsch, Elizabeth C Beseler, Katie Beshai, Boulos Betman, Shane Bettington, Mark ,200 Bevilacqua, Generoso Beydoun, Rafic ,243 Bezerra, Stephania M ,247 Bezieau, Stéphane Bhagat, Govind ,253 Bhaijee, Feriyl Bhall, Ritu Bhalla, Amarpreet Bhan, Atul Bhandari, Vijendra Bhardwaj, Mansi Bhardwaj, Nitin Bhargava, Parul Bhargava, Rohit...115,...125,179,196,237 Bhaskaran, Archana Bhat, Rukhmi Bhattacharjee, Meenakshi Bhattarai, Ava Bhavsar, Shweta Bhimji-Pattni, Sonal ,158 Bhuiya, Tawfiqul A Bhullar, Jasneet S Bi, Chengfeng Bi, Rui ,215 Biagi, James J Bibars, Wafi ,212 Bibbey, Scott Bibbo, Marluce Bidart, Jean-Michel Bidet, Yannick Biernacka, Anna Biffoni, Marco Bignon, Yves-Jean Bijol, Vanesa...74,105 Bilir, Birdal ,246 Billings, Steven D... 22,24,27, 93, , 235, 241 Billis, Athanase ,203,246 Bilodeau, Elizabeth A Bilotta, Mirna Birkness, Jacqueline Bischoff, Farideh Biscotti, Charles V Bishop, Barbara Bishop, Julie Anne Bishop, Justin A... 23, 58, 87, 100,...117, 126,136,137,150,151, ,239, 257 Bittar, Humberto Trejo ,187 Bitterman, Pincas ,180 Bitting, Angela Bivalacqua, Trinity J ,176 Bivin, William W Bixby, Dale Bizzarro, Tommaso ,239 Black, Dalliah M Black, Jennifer Black, Margaret A Blackwell, Rebecca Blakely, Morgan Blakesley, Rick Blanco, Luis Z ,140 Blanco, Paula Blanes, Alfredo ,243 Bledsoe, Jacob R ,228 Bleiweiss, Ira...63 Blessing, Melissa M Blevins, Allen R Block, Norman L Bo, Ping man, Lisa Boccardo, Simona Bochaton-Piallat, Marie-Luce Bochner, Bernard H ,175 Bocicariu, Alina Bocklage, Therese ,194 Bodo, Juraj Boehm, Steffen Boerner, Julie Boerner, Scott L Boers, James Bogardus, Sidney Bogdanska, Anna Boguniewicz, Ann Bohm, Maret Boiocchi, Leonardo Bois, Andreas du Bois, Melanie ,189 Bojanowski, Christine M Bokhari, Aqiba Boland, Jennifer M...105,...112,166,183,188,235,255 Boland, Patrick Bolesta, Edward Bolger, Noel Bollen, Andrew Boman, Bruce Bombi, Josep Antoni ,245 Bombonati, Alessandro Bondzie, Philip A Bonert, Michael ,189 Bongiovanni, Massimo Bonneau, Peter N Bonsib, Stephen...51 Booker, Betty Bookstein, Robert E Boorjian, Stephen A Booth, Christine N Borah, Sumit Borbath, Ivan Borczuk, Alain C... 45, 76, 90, 103, ,211 Borer, Jill Borger, Darrell Borhan, Walaa Boriani, Stefano Boroujen, Amir M Borowitz, Michael Borri, Filippo Borscheid, Rene Borsu, Laetitia Borys, Dariusz Borys, Ewa Boscato, Elena Bosch, Dustin E , 243 Bose, Shikha ,222,242 Bosman, Fred Bossard, Céline Bosse, Tjalling Bossé, Yohan Bossler, Aaron ,236 Bossuyt, Veerle...99,236 Bouda, Jiri Boukhar, Sarag ,229,252 Boulos, Fouad...73 Bouska, Alyssa Boutsen, Laure Bovée, Judith V.M.G...57, 100 Bowden, James Bowles, Daniel ,150 Bowman, Sarah Bowser, Zenica Box, Adrian Boyce, Alison Boyd, Theonia K Boyden, Edward Boyer, Daniel Boyer, Michael Boyle, Suzanne M Bozkurtlar, Emine Bracci, Page Brachtel, Elena ,169,200,234 Bradshaw, Azore-Dee ,245 Braegelmann, Johannes Brainard, Jennifer A ,118, ,218,240 Brais, Lauren Brancely, Dawn ,217 Brand, Randall E ,191 Brandler, Tamar C ,165,239 Brandwein, Margaret Brannigan, Robert E Brassell, Stephen Brat, Daniel J... 96, 129,185,190,...Special Lectures Tab Braun, Alexander L Braunhut, Beth L Braylan, Raul Breau, Rodney H Bredno, Joerg Brenn, Thomas...88,257 Brennan, Michael Brennan, Paul Brennan, Rachel Brenner, David Breslauer, Cori Breuer, Frank Brickman, Arlen Bridge, Julia A... 26,57, 86 Bridges, Alina G Bridgewater, John Brimo, Fadi...123,176,202,257 Briones, Flavio Bristow, Robert Britt, Jacob Britton, Heidi Broaddus, Russell R...103,.110,125,162,192,200,211,212,22...4,241 Brock, Jane E... 54, 216, 238 Brodie, Caroline Broehm, Cory ,194,235 Brogi, Edi... 63,94,136,...168,169,236,237 Brosens, Lodewijk AA Brouwer, Jan Brower, Raven ,207 Brown, Charmaine G Brown, Ian ,174,200 Brown, J Mark Brown, Laura Brown, Marty E Brown, Noah Brown, Ron Browne, Eva P Brufsky, Adam M Brunelli, Matteo Bruner, Andrew Brunot, Angelique ,247 Brunt, Elizabeth M ,183 Brunyé, Tad T Bryan, Andrew Bryan, Brad A Bryant, Britni RE ,158 Bryant, Madalynn Brzostek, Sabrina Racine Bshara, Wiam Bsirini, Caroline ,247 Bu, Fang Buchanan, Daniel ,174 Buchert, Gerald Buckingham, Lela Buckley, Anne Bucur, Octavian Buechler, Steven A Buehler, Darya ,172,248 Buendia, Marie A Bueso-Ramos, Carlos E...70, 105,...162,206,207,227,228 Buglioni, Alessia Buhmeida, Abdelbaset Buhtoiarova, Tatiana N Bukelo, Maria...220, Honors Tab Bull, Shelley B Bullock, Martin...75,137 Bullock, Timothy Bulman, William Bundele, Manish M Bundock, Elizabeth Buonocore, Darren Burack, Richard ,192, ,229 Burgart, Larry...50 Burger, Peter C Burke, Allen P ,147,156, , 245 Burke, Carol ,173 Burke, Kathleen A ,150,...151,168,169,211 Burmeister, Lynn A Burnier, Miguel N ,190 Burns, Kathleen H Burra, Patrizia Burton, Ann Busam, Klaus J Busca, Aurelia Buschmann, Mary Butler-Wu, Susan Butler, Marcus ,219 Butnor, Kelly...93,155 Butowski, Nicholas Büttner, Reinhard Butz, Henriett Buza, Natalia... 90,125,178,...224,236,248,257 Byrne, Michael Byrnes, Kathleen ,167,

336 INDEX C Cabanillas, Maria E Cabeza, Eduardo A Cabezas, Claudia Cabrera-Muñoz, Lourdes Cacciabeve, Nicolas Cacciatore, Matilde ,185 Cagle, Philip T ,188 Cai, Chunyu Cai, Donghong Cai, Emily Cai, Guoping...210,218,239,240 Cai, Lei Cai, Qi Cai, Weiwei Cai, Zhenjian ,198,210 Caillou, Bernard Cajaiba, Mariana M Cajal, Santiago Ramon y. 185,187 Calagua, Carla ,223 Caldwell, James Calhoun, Benjamin C...40, 114, ,237, 257 Caliò, Anna Calkins, Sarah Callender, Glenda G Calonje, Eduardo Calvo, Katherine R Calvo, Maria Teresa R Camacho, Jessica Camara-Lopes, Luiz Heraldo A Câmara, Sara Campbell, Katelynn Campillo-Gimenez, Boris Campo, Elias...153,228,251,252 Campo, Meghan J Can, Nhu Thuy Canales, Jaime Rodriguez , 248 Canavez, Flavio C Canavez, Juliana MS Candela, Ninfa M Canessa, Pier Aldo Cañete-Portillo, Sofía ,222 Cani, Andi Cannell, Emily M Canter, Robert J Cantley, Lewis Cantu, David ,228 Cao, Dengfeng ,180,247 Cao, Weibiao Cao, Wenqing Cao, Xuhong ,122, ,176,191 Capodimonti, Sara Caporelli, Mandi-Lee Caraway, Nancy P Carballo-Zarate, Adrian A Cardona, Diana ,183,203 Cardona, Ken Carey, John L ,234,250 Carlson, J Andrew Carneal, Eugene ,208 Carneiro, Fatima Carney, John Carpio, Luis Carr, David Carr, Richard A Carrasco, Miquel Angel Carreira, Christine Carrilho, Carla Carrillo-Polanco, Luis Carroll, Martin Carroll, Sarah ,142 Carroll, Steven L...57 Carskadon, Shannon Carter, Cody Carter, Jodi Carthon, Bradley C Cartun, Richard Carty, Sally E Carusi, Daniela A Caruso, Carla Carvalho, Paulo A Casadei, Riccardo Cascio, Michael ,208,227 Casey, James Casey, Laura Cashen, Amanda Casler, John...99 Cason, Zelma Cassidy, Daniel P Castellar, Edgardo R Parrilla Castells, Antoni ,245 Castillo, Paola Castle, Philip E Castonguay, Mathieu C...48, ,188 Castro-Echeverry, Eduardo Castro, Karen T Galvis Catenacci, Daniel Cates, Justin MM Catherino, William Cathomas, Gieri Cathro, Helen P Catino, Anna Maria Catlow, Krista Caturegli, Patrizio Caudle, Abigail S Cayre, Anne ,172,196 Celis, Verónica Celli, Romulo ,163,...172,199,210,245 Cellini, Ashley ,139 Cenci, Tonia Centeno, Barbara Centonze, Giovanni Cerbelli, Bruna Cerda, Sandra Cesari, Matthew ,147,178 Ch ng, Sydney Chadburn, Amy... 22,23,152,252 Chadwick, Barbara E Chadwick, Dianne Chaft, Jamie Chahine, Joeffrey ,132 Chahine, Saad Chaib, Oumaima ,125,179 Chain, Krista Chakrabarty, Bipasha Chakraborty, Baidarbhi ,167 Chakravarthi, Balabhadrapatruni VSK Chama, Allen C Chambers, Setsuko Chan, Alexander Chan, Anna Chan, Cheri Chan, Emily ,178,217 Chan, Joanna Chan, Kin Chan, May Chan, Wing C...192,228,229,251 Chandan, Vishal S ,183 Chandarlapaty, Sarat Chandler, Jocelyn B Chandra, Ashish Chang, Alicia H Chang, Angela Y Chang, Anthony ,128,182 Chang, Chung-Che Chang, Hong ,207,227 Chang, Jason C Chang, Jenny Chang, Kai-Ping Chang, Kenneth ,235 Chang, Koping Chang, Martin C Chang, Michael Chang, Nina Chang, Qing Chang, Ruby Chang, Steve Chang, Young Hwan Chapel, David B Chapelle, Thierry Lamy de la Chapman, Christopher Chapman, Erin Chapman, Jennifer Chapman, William C Charaghvandi, K Ramona Charames, George ,197, ,256 Charles, Stoudenmire J Charu, Vivek ,168,217 Charville, Gregory ,178,212 Chastain, Elizabeth Chatterjee, Deyali Chau, Karen Chau, Nicole G Chaudhary, Adeel Chaudhary, Rahman ,195 Chauhan, Subhash Chaux, Alcides Chavez, Jesus A Cheah, Alison L Chebib, Ivan ,194,240 Cheeney, Gregory Chekmareva, Marina Chekol, Seble Chelliserry, Jijumon Chen, Benjamin.127,128,183,257 Chen, Betty Chen, Danqi Chen, Dong Chen, Fei Chen, Hannah H ,119, ,213 Chen, Hui...150,155,162,234 Chen, Huijiao Chen, Jie Chen, Jin Chen, Lee-may Chen, Li Chen, Longwen...89 Chen, Min Chen, Mingyi ,235 Chen, Rong Chen, Shaoxiong ,203, ,222 Chen, Shaxioang Chen, Sheau-Chiann Chen, Shuo Chen, Tiffany Chen, Wei ,172, ,200,222 Chen, Weina ,208,251 Chen, Weiwei ,216 Chen, Weiyi Chen, Wen Chen, Wenjin Chen, Xiaowei ,195 Chen, Xin Chen, Yan Chen, Yao-Tseng Chen, Ye ,245 Chen, Yen-Ying Chen, Yi-Bin Chen, Yi-Fan Chen, Yi-Hua Chen, Yigu Chen, Yingbei , 123, 133,175,...176, 201, 203,257 Chen, Yongmei Chen, Yuan Yuan ,228,252 Chen, Yuhchyau Chen, Yunn-Yi ,108,...162,168,196,215 Chen, Zhengming ,139, ,196 Chen, Zi ,226 Chen, Zongming E ,221 Cheng, Angela S ,248 Cheng, Elaine Y Cheng, Esther ,196 Cheng, Heather H Cheng, Jason L , 162 Cheng, Jinjun ,212 Cheng, Jinrong ,246 Cheng, Liang ,133, ,194,201,203,204,208,228 Cheng, Lin Cheng, Mingyu Cheng, Tina Cheng, Ting-Yuan David Cheng, Xin Min Cheng, Yu-Wei , 118, 197 Cheng, Yufan Chennat, Jennifer S ,191 Chennubhotla, S C Cherian, Sindhu Chernichenko, Maria Chernock, Rebecca ,125, ,205,257 Cherry, Athena ,208,212 Chetty, Runjan ,199,219 Cheung, Annie NY Chevarie-Davis, Myriam Chevez-Barrios, Patricia...53,67, Cheville, John C ,124,...175,177,203,222,246,247 Chew, Jason B Chhieng, David ,141 Chi, Zhikai ,221 Chianchiano, Peter Chiang, Sarah Chiappetta, Caterina Chibbar, Rajni Chibon, Frédéric Chic, Nuria Chiesa-Vottero, Andres

337 INDEX Chiforeanu, Dan Childs, Margaret Chinegwundoh, Francis Chinnaiyan, Arul M ,122,...175,176,191,197 Chinnaswamy, Girish Chiosea, Simion...58, 136,...137, 138,150,256 Chioureas, Dimitrios Chiriboga, Luis Chirip, Venus Chisholm, Karen M Chitale, Dhananjay ,169, ,234 Chiu, April ,227 Chkheidze, Rati Chlipala, Elizabeth Chng, Tze Wei Cho, Byoung Chul Cho, Eun Yoon ,197 Cho, Judy Cho, Junhun Cho, Margaret ,165,245 Cho, Woo Cheal Cho, Yoon Ah Choi, Eun-Young K Choi, Euna Choi, Hyejeong ,255 Choi, Julia Choi, Kyung Un ,200 Choi, Sarah Choi, Sung-Eun Choi, Won-Tak ,167, ,174 Choi, Yoonla Choksi, Rachana ,116 Chon, W James Chopra, Shefali Chosdol, Kunzang Chottová-Dvořáková, Magdalena Chou, Pauline Choueiri, Toni K Chow, Christine ,255 Choy, Bonnie ,117,146 Chren, Mary-Margaret Christensen, Hannah M Christensen, Paul Chu, Jinah...168,197,221,255 Chu, Kevin Chu, Peiguo Chu, Tianming Chu, Ying-Hsia ,242 Chua, Kenon S Chui, Michael Herman Chumbalkar, Aibhav Chung, Ji Myung Chung, Jin-Haeng Chung, Sun M Chung, Yumin Church, James Chute, DeborahJ...27, 119, ,143 Cibas, Edmund S ,172 Cicek, Ali ,169 Cicek, Ali Fuat Cieply, Kathleen Cimbaluk, David Cimic, Adela ,214 Cimická, Jana Cimino-Mathews, AshleyM...22,...23, 63,84,115,139,168 Cin, Paola Dal ,247 Ciomek, Natalie A Citron, D Clark, Beth Z ,125, ,179,237 Clark, Ian ,167 Clark, Jonathan ,137 Clark, Peter E Clarke, Ann E Clarke, Blaise... 75,124,164,179 Clarke, Loren Clay, Michael R Clayton, Adam Clemens, Mark W Clements, June Clemmensen, Tyler Clendenning, Mark ,174 Clerc, Johanna Climent, Fina Clinton, Lani K ,200,221 Cloe, Adam Clouston, David Cluxton, Chris Clymer, Beth Coach, Julia Coates, Ryan Cobb, Jared Coberly, Jared Cocchi, Stefania Cochrane, Dawn R Cocker, Rubina S Cocks, Margaret Coen, Matteo Coffey, Amy M Coffin, Cheryl M...57 Coffman, Brittany B Cohen, Aaron J Cohen, Arthur H Cohen, Cynthia ,117, ,128,129,133,139,150,158, ,195,204,218,220,231,236 Cohen, David W Cohen, Jarish ,212 Cohen, Jean-Marc ,238 Cohen, Mark Cohen, Paul J Cohen, Victor Colafrancesco, Serena Colasse, Elodie Colby, Thomas V Cole, Gary Colecchia, Maurizio Colling, Richard Collins, Brian ,257 Collins, Jennifer A Collins, Laura C... 22,24,103 Collins, Lucine Collins, Michael T Collins, Scott A Collinsworth, Amy Colomo, Luis ,251 Coma, Mar Iglesias Comperat, Eva ,246 Compton, Margaret Conceição, Raquel C Conces, Miriam R Cone, Molly Connelly, Caitlin ,177,231 Connors, Katherine Conrad, Douglas Conte, Gabriele Del Contreras, Alejandro Conyers, Jeffrey A Cook, James R...22, 66,... 70, 251,253 Cooke, Robin...62 Cooney, Anthony Cooper, Benjamin Cooper, Dennis Cooper, Kumarasen...72,249 Cooper, Lee AD Copeland Jr., Robert L Copeland, Karen Coppa, Jorgelina Coppola, Domenico ,133 Corazza, Gino R Corcoran, David L Corey, Eva Cornejo, Kristine ,217 Cornell, Lynn D ,182, , 257 Cornish, Toby C Correa, Hernan Corredor, German ,211 Corse, Tanner D Cortese, Cherise Corti, Barbara Cortright, Valerie ,220 Corvalan, Alejandro H Cosar, Ediz F ,217 Cosio, Fernando ,254 Costa, Estela Costa, Larissa BE ,203,246 Costello, Brian A Costinean, Stefan Cote, Michele L Cote, Richard J Cotelingam, James Cotiis, Dan de Cotler, Scott Cott, Elizabeth M Van Cotta, Claudiu V , 257 Cotter, Maura Cottrell, Tricia R ,235 Cottrill, Elizabeth Cotzia, Paolo Couce, Marta E Coughlin, Geoff Courville, Elizabeth L ,252, Cousineau, Craig Couto, Joe Covach, Adam Covinsky, Micheal Cox, Bettye Cox, Brian Cox, Jesse ,225 Cox, Roni ,222 Coy, Shannon Cracolici, Vincent M Craddock, Kenneth J Crafter, Sharon Craig, Jeffrey W Cramer, HarveyM...25, 142, , 189 Crane, Genevieve (Eve) M...25 Crapanzano, John Crawford, John Crawford, Scott Crespo, Gonzalo Crisi, Giovanna M...52, 211 Crist, Henry ,151,171 Cristando, Camilla Cristofano, Claudio Di Croce, Sabrina Cronin, Mary Kate Cross, Janet Crotty, Rory ,234 Crowe, Sheila E Crowe, William Cruise, Michael ,173 Crum, Christopher P ,178, ,249 Crumley, Suzanne ,211,224 Cruz, Ofelia Cuatrecasas, Miriam ,245 Cubilla, Antonio ,222 Cuda, Jackie Cuervo, Juliana Cuevas-Ocampo, Areli K ,194 Cuevas, Martin ,222 Cui, Isabelle H ,244 Cui, Min Cui, Wei ,208 Cui, Xiaoyan ,139,140 Cui, Ya Cullen, Jennifer ,147,223 Culver, Brady P ,256 Cummings, Bill...70 Cummings, Oscar W Cunha, Isabela W ,221, ,247 Cunningham, Ashley M Curci, Nicole Curry, Choladda V Curry, Jonathan L ,186, ,228,241 Curtis, Mark T Cuzick, Jack Cymes, Karina Cyrta, Joanna ,223 Czader, Magdalena... 70,153,163 Czapla, Agata Czauderna, Piotr Czeczok, Thomas ,182,183 Czerniak, Bogdan Czuchlewski, David D D Agati, Vivette D Alfonso, Timothy...90,103, ,196, 257 d Amati, Giulia Daaboul, MHD Fayez.125,179,195 Dabbs, David J ,125, ,179,237 Daber, Robert D Dacic, Sanja... 22,26,49,...101,187,219,231 Dagà, Adrià L Dagher, Julien Dahiya, Sonika Dahl, Gary Dahlstrom, Jane...33 Dai, Ding Dairiki, Mutsumi Dalbagni, Guido ,175,176 Dallol, Ashraf Dalton, Leslie

338 INDEX Dalvi, Siddhartha ,127,251 Damodaran, Chendil Damodaran, Senthil Danakas, Alexandra ,247 Danel, Claire Dang, Daniel N Danner, Derek ,249 Dansette, Delphine Dantey, Kossivi ,217 Darcy, Kathleen M Darga, Elizabeth P Darke, Amy K Darras, Natasha Darvishian, Farbod...140,181,196 Das, Binita Das, Kasturi Dasaraju, Sandhya Dashti, Nooshin K ,175 Dastani, Zari Datta-Mitra, Ananya Datto, Michael Daugaard, Søren Daum, Ondrej ,202,203 Dauplat, Marie-Melanie Davenport, Matthew Davey, Scott Davicioni, Elai Davick, Jonathan J David, Marjorie P David, Stephanie N ,238 Davidoff, Andrew M Davidson, Tara M Davies, Michael A ,241 Davila, Jaime ,220 Davion, Simone Davis, DrewG... 40, 143,174 Davis, Eric M Davis, Jessica...40 Davis, Thaylon Davis, Warren Davison, Jon ,219 Dawson, Andrea...88 Dawson, Heather ,175 D Cruz, Anil De Abreu, Francine B ,191, ,256 De Andrade, Tathiana Azevedo Dean, Christina Dean, Stephanie Deaton, Ryan ,159 Deavers, Michael ,188 Debelenko, Larisa ,214 Debeljak, Marija De Bono, Johann Decamp, Malcolm Decker, Melissa DeCross, Arthur Dedes, Konstantin Deeken-Draisey, Audrey ,242 Deen, Malik DeGallo, Robin Degnim, Amy deguzman, Jose Deharvengt, Sophie J...191, ,256 Dehner, Louis P Deimling, Andreas von Deisch, Jeremy Delahunt, Brett ,222,246 Delair, Deborah DeLellis, Ronald A...27 Delgado, Silvia dell Aquila, Marie Delprado, Warick DeLuca, Juliana Demaria, Sandra ,196 Demetri, George Demetris, Anthony J Demicco, Elizabeth G...69, 194, Deng, Fang-Ming ,146,...147,171,181,223 Deng, Xiaobing Dennis, Katie ,168 Denroche, Rob E Deodhar, Kedar Derkyi-Kwarteng, Leonard Desai, Neil Deshpande, Charuhas Deshpande, Vikram ,169,...193,194,200,219,225,228, ,234 Desmeules, Patrice ,188,193 Desouki, Mohamed M...110, ,238 Dessanti, Paolo Dessen, Philippe Devereaux, Kelly ,212 Devitt, Katherine A Devouassoux-Shisheboran, Mojgan Dewar, Rajan ,143,158, ,208 Dey, Vivek DeYoung, Barry R Dhall, Deepti ,130,200 Dhanasekaran, Saravana...122, 191 Dhand, Abhay Dhani, Neesha ,213 Dhillon, Jasreman ,218 Dhingra, Sadhna Dhir, Rajiv ,246 Dhorajiya, Poojaben Dias-Santagata, Dora ,155 Dias, Ana B Toledo Dias, Beatriz Diaz-Cano, Salvador ,243 Diaz-Gomez, Berlly L ,125 Díaz, Alba Diaz, Miguel F Palma Diaz, Sherley Dickler, Maura ,237 Dickson, Brendan C...69,...166,195,197,236,256 Didonato, Rosemarie Diez-Valle, Ricardo Dill, Erik Dillon, Deborah A Dillon, Jessica ,225 Dillon, Patrick DiMarco, Michelle Dimichelis, Francesca Dimitravo, Nevenka Dimitrova, Nevenka ,204 Dinali, Mohamed El ,252 DiNardo, Courtney Ding, Qingqing ,216 Ding, Xiangdong Ding, Xianzhong ,132, ,213 Ding, Yanli Ding, Yi ,192 Dirks, Dawn C Dishop, Megan K...68 Dittmann, David ,211 Divatia, Mukul... 67,186,235 Divya, P Djalilvand, Azita Djordjevic, Bojana ,110,...124,147,178,225 Dlouhy, Ivan Dmetrichuk, Jennifer M ,189 Dmitriev, Alexey Dodd, Anna J Dodd, Leslie Dogan, Ahmet Dogan, Snjezana ,192 Dolderer, Daniel Dolezal, Anna Dolkar, Tsetan Domingo-Vidal, Marina Dominguez, Carolina ,157 Domínguez, Emeli Dominguez, Hugo Dominika, Ryba Don, Michelle ,222,253 Donaldson, Alana R Donaldson, lana R Donati, Davide M Done, Susan J Dong, Fei...112,178,201,226 Dong, Yimin Donson, Andrew Dorfman, David M Dorko, Ken Dorn, David Dorris, Kathleen Douds, Jonathan J Dowdy, Sean C Dowling, Ryan JO Downes, Michelle R , 246 Downing, James R Doxtader, Erika E Doyle, Alden Doyle, Brendan Doyle, Leona A... 23, 27,52, , 254, 257 Doyle, Maria M Doyle, Scott Draganova-Tacheva, Rossitza Drage, Michael G...22, 120 Drakos, Elias Drebber, Uta...70 Dresser, Karen ,128,244 Drevin, Linda Drilon, Alexander ,192 Driver, Brandon ,188 Dromparis, Peter Drotar, Nancy Drui, Delphine Drumheller, Bradley Drwiega, Joseph Dry, Sarah ,138 Du, Jing Duan, Kai ,179 Dubova, Magdalena Dubovy, Sander...53 Duboy, Jon Dubuc, Adrian ,185 Ducar, Matthew Ducatman, Barbara S...68 Duckworth, Lizette Vila Duensing, Stefan Duffield, Amy Dugay, Frédéric Duggan, Maire ,250 Duker, Nahum ,167 Dummer, Reinhard Dumouchel, Justin Dumur, Catherine I ,231 Duncavage, Eric ,118, ,228 Dunglison, Nigel Dunne, Richard F Dunseth, Craig Dunya, Gabriel Duose, Dzifa Dupont, Andrew W Dupuis, Frantz ,247 Dupuy, Damian E Dureau, Zachary ,223 Durkin, Lisa Dursun, Nevra Duska, Linda Dvanajscak, Zeljko ,208,209 Dye, Daniel...23,257 Dyke, Alison Van ,255 Dyke, Daniel L Van Dzinic, Sijana E Early, Caroline East, Ellen G , 158 Eastham, James Ebb, David Eberlein, Jens Ebert, Benjamin ,207 Eble, John N...25, 27,...123,133,167,201,204 Edeiken-Monroe, Beth S Edeline, Julien ,209,247 Edelweiss, Marcia ,168 Edgerton, Mary E Edlefsen, Kerstin L Edmund, Liz ,230 Edupuganti, Subhash Edwards, David Edwards, Dean P Edwards, William D Egan, Caoimhe Egevad, Lars... 46,107,202, ,246 Eghtesad, Mansooreh Ehdaivand, Shahrzad Eich, Marie-Lisa ,176 Eickhoff, Jens Eifert, Cheryl L Eisch, Robin Eisenhut, Carol Ekladous, John El-Gendi, Saba ,238 El-Mofty, Samir K ,136,205 El-Naggar, Adel K El-Rayes, Bassel El-Rayes, Dina El-Zammar, Ola Elalfy, Zahraa S Elbanan, Mohamed G Elemento, Olivier ,212,252 Elenitsas, Rosalie Elfandy, Habiba

339 INDEX Elfatairy, Kareem Elghetany, Mohamed T ElHassan, Hiba Eliassen, A Heather Eliaszadeh, Shohreh Elishaev, Esther ,179 Ell, Christian Elli, Francesca M Ellimoottil, Chandy Elliott, Bruce Elliott, Daffolyn R Fels Elliott, Robin Ellis, Carla ,217,254 Ellis, Ian Ellison, David Elmore, Joann G Elortza, Felix Elsayes, Khaled M Else, Tobias Elshamy, Mohammed Elsheikh, Tarik M...44, 109 Eltoum, Isam-Eldin ,205 Elvin, Julia A ,114,115, ,123,126,129,150,172,177,...187,191,192,193,231 Elwahab, Sami Ely, Kim ,239 Emanuel, Patrick...89 Emberesh, Myesa ,252 Emens, Leisha A Emerson, Ryan Emile, Jean-Francois Emmadi, Rajyasree Enbom, Elena Eng, George England, Jonathan S English, Dallas Enke, Charles A Enlow, William Ennis, Marguerite Ennis, Rachel Epari, Sridhar Epelbaum, Fanya Epstein, Jonathan...97 Epstein, Jonathan I ,122,146,...175,176,177,203,223,224 Erbarut, Ipek Erho, Nicholas G Erickson, Lori ,247 Erlich, Annette Ernst, Wayne Ertan, Atilla ,243 Ertoy, Dilek Eschbacher, Jennifer Eschrich, Steven A Esebua, Magda ,176, ,248 Eshleman, James R ,162 Eskandari, Ghazaleh Eskandari, Mohammad Eslami, Arash Esmaeli, Bita Esnakula, Ashwini K ,183, ,229 Esopi, David Esper, Lawrence Espinal, Paula S ,247 Espinal, Paula Sofia Esposito, Evangelina ,190 Esposito, Irene Esteller, Manel Estopinal, Maria D Estrada, Monica V Estrine, Dolores Eszlinger, Markus Ettel, Mark Ettler, Helen Euscher, Elizabeth ,164 Evans, AndrewJ... 42, 192,202,...206,229,245, 246 Evans, Andy...98 Evans, Chris Evans, James J Evans, Mark Evasovich, Maria Ewalt, Mark D Ewaz, Abdulwahab Ewton, April Ewunonu, Henry Eze, Ogechukwu Pearl ,121,...163,173,200,219,244 F Faber, Erin N...40 Fabrizio, David ,123, ,129,150,172,177,187,191, ,193,231 Facchetti, Fabio...60 Fadare, Oluwole... 61,110,140,...158,179,180,224,237 Fadda, Guido ,164 Fakhry, Carole Fallon, John...48 Fallon, John T ,128,179,...185,201,203,204,209, ,214,256 Falzarano, Sara M Fan, Cathy Fan, Fang ,141,168 Fan, Hongxin Fan, Meiyun Fan, Minghua Fan, Rong Fan, Wen Fan, Xuemo ,181,242 Fanburg-Smith, Julie ,213 Fang, Catherine Fang, Hong ,207 Fang, Lianghua ,234 Fang, Xiangming Fang, Yanan Faquin, William C... 26, 44, 64, 100, , 138, 150 Farag, Mina Faragalla, Hala Farahani, Navid Farghaly, Hanan Farhat, Nada Farid, Heba Farinha, Pedro Farmer, James Farooq, Fahad Farooq, Taliya ,176, ,211,229 Farooqi, Midhat Farrag, AbdelRazik H Farrell, Jessica M Farris, Alton B Farris, Brad Farshid, Gelareh...63 Faruqi, Asma Farver, Carol... 92,100,106, ,187 Farver, Carol F...22,23 Fasanella, Kenneth E ,191 Fathallah, Lamia Fatheree, Lisa A ,157 Fatima, Nazneen Faulkner-Jones, Beverly E ,182 Fayad, Miriam Fayed, Doha E Fayyaz, Ahmed U Fayyaz, Silvat S Fazeli, Roghayeh Fazlollahi, Ladan Feasel, Patrick Fedeli, Franco Federman, Noah C Fedor, Helen Fedoriw, Yuri Fedorova, Maria Feely, Michael ,221 Fehniger, Todd Fei, Baowei Feilotter, Harriet Feldman, Alexander Feldman, Darren Feldman, Michael ,181 Felisiak-Golabek, Anna ,241 Felix, Juan Feng, Xiaojun Feng, Yingdong ,246 Feratovic, Rusmir Ferda, Jiri Fernandes, Helen ,210, ,243 Fernandez-Delgado, Rafael Fernandez-Pineda, Israel Fernandez-Pol, Sebastian ,151 Fernandez, Anthony P Fernandez, Martin P Fernandez, Pedro Fernández, Pedro L...59 Fernandez, Susan Ferrarrotto, Renata Ferrazza, Laura Ferré, Elise MN Ferreccio, Catterina Ferreira, Joana Ferrell, LindaD... 26, 166,183 Ferrell, Paul B Ferrer, Alejandro Ferris, Brad...23,257 Ferro, Paola Ferrone, Cristina Ferrone, Soldano Ferry, Judith A... 47, 228,253 Fervenza, Fernando C ,253 Fetais, Alanoud R Ffrench, Brendan Fidai, Shiraz ,247 Fidan-Ozbilgin, Ozlem Fidler, Mary E ,182 Fiel, M Isabel... 50, 129,183,230 Fields, Kristina Fierro-Fine, Amelia ,126,157 Filardi, Dominic A Filippo, De Braud Finch, C Findeis-Hosey, Jennifer J...184,...190,198,221,230,245,254 Fine, Jeffrey L Fine, Samson W...25, 46, 98,...107,123,133,175,176,201 Fineberg, Susan Fink, Daniel Finkelstein, Sydney ,205, ,238 Firchau, Dennis Fiscella, Julietta Fischer, Andrew H , 238, 239 Fischer, Sandra Fish, Jennifer Fishbein, Gregory A Fisher, Hugh A...122,123,129,177 Fisher, Kurt Fisher, Kurt W...40 Fitzgerald, Michael A Fitzgerald, Rebecca C Fitzgibbons, Patrick L. 49, 156,157 Flake, Darl Flannelly, Grainne Flavin, Ricahrd Fleming, Evelyn L Fleming, Jason B ,210 Fleming, Jude Fleshner, Neil E Fletcher, Christopher DM...22,...165,166,188,194,...236, Honors Tab Fletcher, Jonathan Flood, Trevor A Florea, Alina Dulau Flotte, Thomas J ,241 Flynn, Jefferey Fogo, Agnes ,253 Foix, Maria Pane Foley, Carolyn Folkerth, Rebecca ,186 Folkins, Ann ,257 Foll, Matthieu Follett, Robert Folpe, Andrew L... 47, 52, 90, 101, ,165,166,188,193, ,220,222 Fong, Andrew Fonseca, Isabel...75,137 Fonseca, Pedro Fonseca, Ricardo Fonstad, Rachel Foo, Wai Chin ,210,220 Foran, David Forcada, Pilar Forcione, David G Forcucci, Jessica A Ford, Andrew Forde, Patrick M Foreman, Nicholas Forero, Andres Fornino, Daniele Forns, Xavier Forrest-Hay, Alex Forse, Catherine Fortuna, Danielle ,221 Foster, Nathan R Foulkes, William ,164 Fowle, Evan J Fox, Sharon Foye, Adam Fraer, Mony

340 INDEX Fraig, Mostafa M ,252 Frampton, Garrett ,122,...123,126,129,150,172,177,...187,191,192,193,231 Franchi, Alessandro ,235 Franco, Catalina Frank, Gina Liviana Frank, Renee ,170,249 Frankel, Arthur Frankel, Wendy L...22,...120,121,172,174,183 Franklin, Donald Frauenhoffer, Elizabeth E Frazier, Shellaine R ,176 Frederick, Paul D Freed, Darren Freedman, Orit Freitas, Declan de Freitas, Leandro LL ,203,246 French, Christopher French, Samuel W Fried, Karen Friedman, Joel ,223 Friedman, Kenneth Friedman, Lisa Frierson, Henry F Frigola, Gerard Frishberg, David Fritcher, Emily G Barr , 255 Fritchie, Karen... 88,193,194, ,235,257 Frizzell, Kimberly Fromm, Jonathan Frosina, Denise Frost, Marlene Frye, Joseph S Fu, Kai ,229 Fu, Xiujun ,188 Fu, Yumei Fuchs, Charles Fuda, Franklin Fuentealba, Patricia Fuhrman, Kit Fujita, Kazutoshi ,247 Fukatsu, Akitoshi Fukayama, Masashi Fukuda, Yuh Fukuhara, Noriaki Fukunaga, Masaharu Fukuoka, Junya...154,155,156,187 Fukushima, Noriyoshi ,210 Fulford, Paul Fullen, Douglas Fuller, Christine...41,72 Fuller, Gregory N... 26, 28, 29, 184 Fuller, Maren Fulmer, Clifton G Fulton, Regan ,176,201 Fung, Po Chu Furlan, Daniela Furtado, Larissa V...49 Furth, Emma E Furuya, Mitsuko Fusco, Nicola Fuster, Carla Fyfe-Kirschner, Billie G Gaafar, Ayman Gabbiani, Giulio Gaber, Germaine Gabrielson, Ed ,154 Gadde, Ramya ,196,203 Gagné, Andréanne , 155 Gainor, Justin F Gaisa, Michael ,141 Gakinya, Samuel Galbo, Filippo D Galera, Pallavi Kanwar Gales, Jordan M Gallagher, Michael Gallagher, Torrey L Gallan, Alexander Gallego, Soledad Galli, Susana Galliano, Gretchen Gallinger, Steven ,213 Galon, Jerome...83 Galuppini, Francesca Gambarotti, Marco ,235,236 Gambato, Martina Gan, Qiong Gandara, David R Gandhi, Manoj ,184,229 Ganesan, Raji ,178 Gani, Faiz Ganly, Ian Gao, Chen Gao, Dana Gao, Dongxia Gao, Faye Gao, Juehua ,211 Gao, Yi Garanito, Marlene Garces, Sofia ,228 Garcia-Bragado, Federico Garcia-Buitrago, Monica...142, ,239,255 García-Domínguez, Daniel J Garcia-Escolano, Marta Garcia-Manero, Guillermo Garcia-Martinez, Araceli García-Mejías, Rosa Garcia-Moliner, Maria L ,186 Garcia-Tsao, Guadulupe Garcia, Christopher Garcia, Ciro ,190 Garcia, Elizabeth ,226 Garcia, Felip Garcia, Joaquin ,256 Garcia, Rochelle Gardner, Jerad M... 25,54,79 Gardner, Juli-Anne ,220 Gardner, Paul Gardner, Tracie Garg, Karuna ,257 Garg, Shipra ,235 Garg, Swati Garrett, Erin Garrido, Marta ,252 Gars, Eric Garzon, Angie V Gascoyne, Randy ,251 Gasparotto, Daniela Gast, Katherine Gaston, Daniel ,243 Gaston, Elizabeth Gatalica, Zoran Gates, Peggy Gattuso, Paolo ,136,151, ,186,205 Gaut, JosephP... 51, 128,254 Gawelek, Kara Gay-Bellile, Mathilde Gay, Laurie M ,114,...115,122,123,126,129,150, ,177,187,191,192,193,231 Gay, Nick J Gazzola, Anna Ge, Yimin ,141 Gedikoglu, Gokhan M Gehlbach, Daniel Geisinger, Kim R ,132,240 Geisler, Daniel L Gejman, Roger Geller, Matthew Geller, Rachel ,223 Gellert, Lan L Gelwan, Elise Genco, Iskender Sinan Gener, Melissa AH Gentry, John D Genty, Carlos Genzen, Jonathan George, David George, Eva Vertes...22, 198 George, Sudeep P George, Tracy...70,103,...127,153,162,208 Geromes, Ariana B Gersch, Christina Gershenwald, Jeffrey E Gerszten, Enrique...59 Gesztes, William R ,147, ,245 Gettler, Kyle Geyer, FelipeC ,150,151, ,169,211 Geyer, Julia T... 76, 206,227 Ghabril, Marwan Ghaffari, Abdi Ghaffarieh, Alireza Ghai, Ritu ,205 Ghai, Sangeet Ghanaat, Mazyar Ghanem, Tamer Ghanim, Marcel T ,179,195 Gherasim, Claudia Ormenisan ,158,231 Ghiaseddin, Ashley P Ghildyal, Abhilasha Ghosh, Abheek Ghosh, Toshi ,182,192 Ghoshal, Kalpana Ghossein, Ronald ,150, ,238 Ghuzlan, Abir Al ,239 Gi, Toshihiro Giacomelli, Luca Gianduzzo, Troy Giannico, Giovanna ,177,224 Giannini, Caterina ,185 Giardiello, Francis Gibb, Ewan A Gibril, Manal Gibson, Briana Gibson, Christopher J ,207 Gibson, Ian W Gibson, Joanna Gibson, Sarah E ,252 Gibson, William ,243 Gilbert, Natalie Gilks, Blake...33,61,110,178,180 Gilks, C Blake... 26, 75, 106, ,179,248 Gill, Anthony J ,202,...Honors Tab Gill, James Gill, RyanM... 23, 50,114,...166,183, 184,257 Gill, Sharlene Gillespie, Theresa W Gilliland, Mary ,167 Gilmore, Hannah ,211 Gimenez, Cecilia E Ginter, Paula...108,139,140,216 Giordano, Carla Giordano, Thomas J.. 43, 100, 119 Giorgadze, Tamar.76,142,176,189 Girgis, George Glaser, Adam K ,245 Glass, Carolyn H ,170,189 Glasser, Daniel Gleeson, Noreen Gleeve, Martin Glenn, Martha J Glisson, Bonnie Glover, Michael Gnepp, Douglas Go, Christopher Go, Ronald S Gobbo, Stefano Gocke, Christopher D ,235 Goda, JayantSastri Goebel, Emily Goecks, Jeremy Goel, Swati Goerke, Dayna M Goggins, Michael G Gogineni, Swarna Gohlke, Amanda ,124 Gokmen-Polar, Yesim ,...195,215 Goldberg, Michael E Goldberg, Richard M Goldblum, John R.. 22, 26, ,...109,121,173,190,197, ,200,244 Golden, Jeffrey A...28 Goldenberg, David ,151,171 Goldhoff, Patricia E...24 Goldsmith, Jeffrey D.. 25, 156,157 Goldstein, Leanne Goldstein, Steven Gollamudi, Jay Gollapalle, Esha ,209 Golombos, David M Golovyuk, Alexander Gomes, Marcio M Gomez-Fernandez, Carmen...169, ,239 Gomez-Gelvez, Juan ,250 Gomez, Adam J , 173,240 Gomez, Carmen ,142,217 Gomez, Felicia Gomoláková, Barbora Gondek, Lukasz Gondim, Dibson D Gong, Shunyou Gong, Yuna Gong, Zimu ,207,

341 INDEX Gonzales-Ericcson, Paula González-Cantú, Yessica Gonzalez-Farre, Blanca ,252 González-Farré, Blanca Gónzalez, Agustin I Gonzalez, Anne Koehne de...183, ,219,229 Gonzalez, Dianelis Gonzalez, Gabriel Acosta Gonzalez, Jorge L ,225 Gonzalez, Juan Gonzalez, Maria Gonzalez, Raul S...25, ,173,184,190,221,245, 257 Goode, Benjamin Goodman, Abigail L...129,151, ,185 Goodman, Eli Goodman, Mark M Goodman, Michael M...143, ,255 Goodwin, Andrew Goodwin, Pamela J Gopalan, Anuradha ,123,...133,175,176,201 Gopinath, Arun Goraya, Shazia ,195 Gorbonos, Alex Gordetsky, Jennifer ,146,...194,203,204,251,257 Gordon, Ilyssa ,244,257 Gordon, Laura Gorlick, Richard G Goswitz, Joseph J Gotlib, Jason R , 153, 206 Goto, Akiteru ,225,250 Goto, Takahiro Gotoh, Momokazu Gottlieb, Chelsea ,125 Goudie, Marissa Gougeon, Francois Gown, Allen M...24, 94,...158,176,201,224 Goyal, Bella Goyal, Kashika Goyal, Rajen Goyal, Tanu ,228 Goytain, Angela ,150, ,235 Grabenstetter, Anne Grada, Zakaria ,247 Gradecki, Sarah E Graham, Mindy K Graham, Rondell ,142,...157,166,183,192,220,255 Graham, Tiffany ,204 Grandori, Carla Grange, Jacob Grant, Michelle L Granter, Scott R Gratzinger, Dita ,218 Grau, Ana Grauslund, Morten Gravet, Claire Gray, Alice L Grayson, Wayne...72 Green, Andrew ,215 Green, Peter HR Green, Ralph Greenwood, Michelle Greer, Adam H Gregory, Kelly J Greiner, Timothy Greipp, Patricia T ,166, ,208 Grenert, James Grewal, Mandeep Griff, Sergej Griffin, Brannan ,214 Griffin, Laura ,256 Griffith, Brent Griffith, Christopher C ,150,...151, 218,240,249, 250 Griffith, Malachi Griffith, Obi Grignon, David...29,98,...123,133,201,203,204 Grignon, David J...24 Grignon, David John...22,26 Grillo, Federica Grimes, Margaret M...27 Grobmyer, Stephen R ,195 Grody, Wayne W...85 Groen, Ruben Grönberg, Henrik Gronchi, Alessandro Grondin, Katherine Groover, Surbhi Grosjean, Fabrizio Grosset, Andrée-Anne Grossmann, Petr Groth, John Grotto, Paolo Gru, AlejandroAriel...24,...115,119,224,257 Grunes, Dianne E ,240 Grzybicki, Dana M Gu, Dongqing Gu, Xiaoping Gu, Xin Guajardo, Andrew Gucer, Hasan Gudi, Mihir Gudino, Cynthia Guedes, Liana Benevides ,223 Guerra, Laura Guerra, Marjorie-Anne R Guetter, Christoph Guha, Sushovan ,243 Guidry, Joseph T Guillen, Francisco Guillory, Bryan Guimaraes, Gustavo C ,222 Guindi, Maha Gularte-Merida, Rodrigo Gulati, Rohit Gulati, Roman Gulavita, Previn Gultekin, Sakir Humayun ( Hume )...40 Guma, Sergei R Gumez, Diego Pascual-Vaca Guner, Gunes Guo, Ailin Guo, Chao Guo, Charles Guo, Hua Guo, Ling ,253 Guo, Ruifeng Guo, Shunhua Guo, Tao Guo, Tianhua Gupta, Anika Gupta, Arjun Gupta, Chhavi Gupta, Ekta Gupta, Gopal ,245 Gupta, Nilesh S ,177, ,203,224 Gupta, Raavi ,199,251 Gupta, Rajib Gupta, Ruta ,137,205 Gupta, Sameer Gupta, Sanjay ,246 Gupta, Sounak ,167,...177,203,222,247 Gupta, Tejpal Gur, Deniz Guragain, Deepti Adhikari Gurav, Mamta Gurcan, Metin Guseva, Natalya ,236 Gutierrez, Francisco Llamas Guy, Cynthia ,183,203 Guzman, Grace ,159,213 Gwin, Katja H Haas, Mark Haba, Reiji Habeeb, Omar Habeebu, Sultan Habermann, Thomas M Hacihasanoglu, Ezgi ,165,255 Hackeng, Wenzel Hadi, Rouba Hadravska, Sarka Hadravsky, Ladislav ,248 Haeri, Mohammad ,252 Hafez, Khaled S ,176 Hafez, Omeed Hafezi-Bakthiari, Sara Haffner, Michael C Haga, Hironori Hagemann, Andrea R Hagemann, Ian ,158 Hagen, Catherine ,198, ,219 Haghighi, Mehrvash Hagiya, Ashley S Hahn, Elan Hahn, Jamie ,154 Haimes, Josh ,225,256 Haines, G Kenneth Hajdu, Cristina Hajifathalian, Kaveh Hajiyeva, Sabina ,209 Hajj, Hiba El Hakim, Shaheed W Hakima, Laleh Hakimi, Ari Halani, Sameer H Haley, Lisa Halimi, Sultan A ,250 Hall, Curtis R Hall, Sean R Hallani, Soufiane El ,184,256 Haller, Florian Halling, Kevin C...86, 241 Halloran, Philip Halushka, Marc... 71,189,257 Hamad, Eman Hamadain, Elgenaid Hamadeh, Fatima T Hamasaki, Makoto ,231 Hamedani, Farid Saei ,237 Hameed, Meera R... 22,57, 236 Hameed, Omar... 27,110,177,238 Hamele-Bena, Diane Hamilton, Michelle D...59 Hamilton, Ronald L Hammad, Abdulrahman Hammad, Nazik Hammer, Richard D ,158 Hammer, Suntrea TG...172, ,209 Hammond, Scott Hamoudi, Rifat Hampel, Heather ,174 Han, Ho-Seong Han, Kathy Han, Lisa ,196,224 Han, Liying ,201 Han, Lucy Han, Min Han, Xiao Han, Xin Hang, Jen-Fan ,217,239 Haninger, Diana Haninger, Diana M Hankinson, Sue Hanley, Krisztina Z ,143, ,180, 257 Hanlon-Newell, Amy Hanna, Matthew G ,180, ,182 Hanna, Mereet Hanna, Wedad ,216 Hannibal, Charlotte G Hansel, DonnaE , 124,158,...176,177,223,247 Hansen, Katrine ,116,224 Hanson, Curtis A Hanson, Joshua A ,194 Hanson, Paul J Hansson, Magnus Hao, Xueli ,175 Haque, Monira Hara, Shigeo Haraldsdottir, Sigurdis Hardin, Heather ,242 Hardwick, David F...26, 29 Hardy, Hunter...23 Hardy, Robert W...25 Harigopal, Malini ,169,236 Harinath, Lakshmi ,246 Hariri, Lida ,188 Hariri, Nosaibah ,237 Harmon, Maureen ,158 Harpaz, Noam ,120,130, ,198,200,210,219,244,245 Harper, Aaron E Harper, Holly L Harrell, Danielle Harris, Nancy ,253 Harris, Wayne B Harrison, Beth T Harrison, Grant ,120,138 Harrison, Thomas Harshyne, Larry A Hart, Eric

342 INDEX Hart, John... 22, 47,92,109,...167,173,198,220,240 Hartley, Christopher ,119,...142,172,176,198,199,219 Hartman, Anne-Renee Hartman, Douglas ,181 Hartmann, Arndt ,159,202 Hartz, Brian Hartzband, Pamela Harzman, Alan Hasebe, Osamu Haseeb, MA , 251 Hashisako, Mikiko ,156 Haspel, Richard...77 Hassan, Mohamed ,252 Hassan, Muhammad Hassanpour, Saeed Hasserjian, Robert P...24, 99,...153,162,207,227,252 Hasteh, Farnaz...115,140,211,237 Hata, Shuko Hatakeyama, Kinta Hatanaka, Yutaka Hatanpaa, Kimmo Hatch, Ellen W Hatem, Joseph Hathuc, Vivian M , 214 Hattab, Eyas M... 24, 41, 184 Hattori, Ryohei Haugg, Anke M Haun, Paul Hausen, Axel zur Have, Cherry Hawley, Dean A Hayajneh, Rami Hayashi, Hiroyuki Hayashi, Kentaro Hayashi, Takuo Hayek, Kinda ,179,195 Hayes, Daniel F Hayes, Malcolm Hazari, Rakesh S He, Hong-Lin He, Jian ,159 He, Jing He, John He, Rong ,127,207 He, Xin ,197 Head, David R Healy, Marie Louise Heaphy, Christopher M ,246 Hebisawa, Akira Hecht, Jonathan Hechtman, JaclynF...91, 120, ,221,243 Hedayat, Amin A Hedley-Whyte, E Tessa Hedley, David ,213,219 Heher, Yael Heher, Yaël K... 23, 82, 156 Hein, Ashley H Hekman, James Helderman, Harold Heller, Debra S...89 Heller, Theo Hellmann, Matthew Hemmerich, Amanda Hemminger, Jessica Henderson-Jackson, Evita Henderson, Les J Hendrickson, Heather Heng, Yujing Jan Hennessy, Max ,151 Henricks, Walter ,257 Henriet, Julien Henriksen, Jonathan Henriksen, Kammi J ,182 Henry, Elizabeth Hensley, Marie Hensley, Martee Heo, Su Jin Herculiani, Amanda P...147, ,246 Herfs, Michael Herlitz, Leal C...51 Herman, Carolyn R Herna, Stuart J Hernández-Iglesias, Teresa Hernandez-Losa, Javier Hernandez-Prera, Juan C...92,104, Hernandez, Andrea Hernandez, Felip Garcia Hernandez, Francisco Hernandez, Loren P Herrera...128,...177,182,203,222 Hernandez, Luz Andrea Herrera, Alex Herrera, Guillermo A...52, ,159,240 Herrera, Mileyka Herring, Nicole Hes, Ondřej , 202, 203 Hess, Paul Hexner, Elizabeth Heymann, Jonas J Hezel, Aram Hickey, Tyler BM Hickman, Richard A ,245 Hicks, David Hicks, Jessica...107,111,146,168 Hicks, John... 52,204,214 Hickstein, Dennis D Hida, Risa Hida, Tomoyuki ,231 Hidalgo, Juliana Higgins, Brandi ,132 Higgins, John P ,230,243 Hijazi, Nouf Hill, Ashley...68 Hill, Charles E...133,185,226,240 Hillen, Lisa Hiltzik, David Himmat, Sayed Hing, Sandra Hirahashi, Minako Hirakawa, Akihiro Hirano, Satoshi Hiraoka, Nobuyoshi ,186 Hirokawa, Mitsuyoshi Hiroshi Hiroshige, Karina Hiroshima, Kenzo Hirsch, Michelle S... 22, 46, 105,...164,178,204,226,247,254 Hisa, Takeshi Hiser, Wesley Hishima, Tsunekazu Hiskey, Matthew Hissong, Erika ,243,244 Hmada, Youssef Al Ho, Bridget Ho, Donald M-T Ho, Ken Ho, Khek Yu Ho, Wanting Hoang, LienN , 164,250 Hobenu, Frederick Hoch, Benjamin Hoda, Rana...64 Hoda, Raza S ,117 Hoda, Syed A...92 Hodges, Kurt ,207 Hodgson, Anjelica ,178,225 Hodjat, Parsa ,226,249 Hodkoff, Alexey A Hodos, Jaccob Hoffman, Robert Hoffmann, Jenny C Hogg, Melissa ,191 Hohenwalter, Mark Holder, Chad A Holladay, E. Blair...54 Holland, Steven M Hollmann, Travis J Hollyfield, Johnathan Holman, Carol Holmes, Chris Holmes, Margaret Holtorf, Heidi Homan, Suzanne ,133 Homer, Robert J Hon, Jane Date Honap, Sayali N Honda, Takayuki Hong, Aram Hong, David ,234 Hong, Jie Hong, Kuick Chik Hong, Seung-Mo ,255 Hong, Sung-Hyeok Hong, Yin Hontecillas, Lourdes Hoogestraat, Daniel HooKim, Kim ,217 Hooper, D Craig Hooper, Jody E , 189 Hopkins, Benjamin D Hopkins, Mark Hopper, John Hora, Milan Horbinski, Craig M Horigome, Naoto Horiguchi, Shinichiro Horlings, Hugo...75 Horna, Pedro Hornick, Jason L... 22, 23, 60, 69,... 94, 103, 110,113,114,137,138, ,166,194,208,226,254, 257 Horowitz, Neil S Horton, Bethany J Horton, Janet K Horton, Meredith Horvai, Andrew E ,165, ,194 Horvath, Bela Hosameddin, Mobashir Hosfield, Elizabeth Hoskin, Tanya Hoskin, Victoria Hosseini, Mojgan ,167,183, ,219 Hou, J Steve Hou, Le Hou, Shuang Hou, Yanjun...108,115,140,236 Hovelson, Daniel H ,197, 223 Howard, Matthew T ,207 Howarth, David J Howell, David N Howell, Lydia P...24 Howitt, Brooke E... 75, 164,178, ,226, 257 Hoyos, Alejandro Velez...74 Hrada, Kenichi Hruban, Ralph H ,130 Hruska, Chad J Hruszkewycz, Andrew Hsi, Eric D , 126,153, ,228 Hsiao, Susan J ,253 Hsieh, James J Hsu, Amy Hsu, Chih-Yi Hsu, Ying-Han R Hu, Buqu Hu, Jianhua Hu, Jingjing ,180 Hu, Shaomin Hu, Shimin...128,153,155,207, ,234 Hu, Zhihong...152,192,226,227 Huang, Anne Huang, Dan Huang, Danning ,173 Huang, Eric C Huang, Fangjin Huang, Hongying ,146, ,223 Huang, James Huang, Jian Huang, Jiaoti Huang, Kuo-Cheng Huang, Marilyn ,249 Huang, Qin ,253 Huang, Richard SP Huang, Shih-Chiang Huang, Wei ,203 Huang, Weei-Yuarn , 243 Huang, Weihua ,128,201, ,209 Huang, Xiao Huang, Xiao-Jun Huang, Yajue Huang, Yanfei ,183,229 Hubbard, Elizabeth W Hubbard, Gretchen K Huber, Aaron R ,221 Hudis, Clifford ,237 Hudnall, Stanley D Hudson, Chad Hue, Susan Swee Shan Huerta-Yepez, Sara Hughes, Ian ,146,245 Hughes, Kenneth T ,254 Huh, Gi Young ,200 Huho, Albert Hui, Ling ,222 Hui, Pei...125,153,163,239,248 Hui, Yiang ,125,177, ,241,247 Hulick, Peter J Hull, April M Humayun, Islam

343 INDEX Humphrey, Peter A... 28,96, 97,...107, 147, Special Lectures Tab Hung, Yin P ,113,138, , 166, 225 Hunt, Bryan ,189 Hunter, Stephen ,185 Huntsman, David G Huo, Lei ,215 Hurlbut, David Hurrell, Sarah L Husain, Aliya N ,186 Husain, Nuzhat ,151,248 Hussaini, Mohammad ,208 Hussein, Deema Hussein, Siba El ,230 Hussenet, Claire Hutchings, Danielle ,200 Hutchinson, Lloyd ,217 Huynh, Tiffany...109,132,155,188 Hwang, Chung Su ,200 Hwang, David H... 23, 112, 257 Hwang, E Shelley Hwang, Helena Hwang, Jin-Hyeok Hwang, Michael J Hyman, David M ,193 Hyun, Michael D I Iaco, Pierandrea De Iacobuzio-Donahue, Christine..211 Iafrate, Anthony ,180 Iafrate, John... 86,112,129,155 Ibrahim, Mohammad Ibrar, Warda Ibuki, Emi Ichikawa, Hiromi Ichikawa, Hitoshi Iczkowski, KennethA...111, 122, ,223 Ide, Hiroki ,247 Idel, Christian Idoate, Miguel A Idowu, Michael O.27, 165,231, 257 Idrees, Afshan Idrees, MuhammadT...46, , 123,133,155,201,204, ,222, 257 Ieremia, Eleni Iezzoni, Julia C...22,26 Igarashi, Ai Iglesias, Mar Igor, Frank Ikegami, Masahiro Ikeri, Nzechukwu Z Ikpatt, Offiong F Illan, Francisco J Illei, Peter ,154,180 Imaoka, Yuki Imperatore, Kailee Inacio, Joao R Inaguma, Shingo ,241 Inamdar, Kedar V ,250 Inghirami, Giorgio G Ingoldsby, Helen Ingram, Davis R ,193, ,195,236 Inoshita, Naoko Inoue, Kosuke Inoue, Satoshi ,247 Inwards, Carrie Ioffe, Olga ,139 Ip, Philip PC Iqbal, Jabed...139,169,211,216 Iqbal, Javeed Irmak, Yasin Irshaid, Lina ,139,140 Isaacs, William Isaacson, Alexandra Isaila, Bogdan Isaji, Shuji Isbell, Lauren Ishak, Elia A Ishida, Kazuyuki Ishida, Naoya Ishida, Ryo Ishikawa, Ryou Islam, Shahid ,225 Isler, Christy Ismail, Mamudo R Ismiil, Nadia Isrow, Derek Itami, Hiroe Ito, Masaaki Ito, Tetsuya Itzkowitz, Steven Iuga, Alina ,199 Ivan, Doina ,191,241 Ivanovic, Marina Ivins, Stephanie Iwenofu, O Hans Iyer, Gopa , 175 Izevbaye, Iyare ,179,255 Izimukwiye, Isabelle J Jabbour, Hossam ,139 Jabbour, Tony El ,251 Jaber, Omar ,235,236 Jackson, Sara...159,205,212,238 Jacobs, Timothy W , 108 Jacobsen, Gordon Jacobsohn, Kenneth Jacome, velyn C Polanco Jaffe, Elaine S...25, 228 Jaffee, Elizabeth Jaffer, Shabnam Jagannathan, Geetha Jaggi, Meena Jain, Deepali ,209,231 Jain, Dhanpat... 50,121,129, ,210,245 Jain, Sarika Jain, Shilpa Jain, Sudhanshi S Jakate, Kiran Jakate, Shriram ,128,219 Jakhi, Tanvi Jakowski, Joe Jalali, Rakesh Jalaly, Jalal B Jalikis, Florencia Jamal, Mohsin Jamal, Siraj M El ,185,...192,214,222,247,252 Jamaspishvili, Tamara Jameel, Zena Jamshed, Sarah ,244 Janaki, Nafiseh ,185, ,246 Janatova, Marketa Janeiro, Alvaro Lopez Jang, Erika L Jang, GunHo Jang, Jinyoung Jang, Kee-Taek ,255 Jang, Kiseok Janostiak, Radoslav Janowczyk, Andrew ,139, ,211 Jaramillo, Lina E Jaratli, Hayan Jardin, Fabrice Jaros, Mark Jarry, Anne Jattani, Rakhi Javidian, Parisa Javidiparsijani, Sara Jawale, RahulM ,173, 211 Jayakumar, Rajeswari ,242 Jayakumaran, Gowtham Jazaeri, Amir A Jebakumar, Deborah ,215 Jebastin, Judith AS Jeck, William Richard Jeffreys, Matthew Jeffus, Susanne ,249 Jen, Jin ,220 Jen, Kuang-Yu Jenkins, Mark ,174 Jenkins, Sarah...156,157,235,242 Jenkins, Taylor M Jennette, J Charles , 182 Jennings, Lawrence ,214 Jensen, Chris ,165 Jensen, Kristin... 23,106,216,257 Jenson, Erik G Jentoft, Mark E Jeon, Nara Jeon, Sora Jeong, Hyeon Joo Jesinghaus, Moritz Jessurun, Jose ,191, ,244 Jeung, Jennifer Jevremovic, Dragan Jeyachandran, Devi ,182 Jeyarajah, Arjun J Jhala, Nirag ,117, ,126,246 Jhun, Iny Jia, Liwei Jiang, Chunjie Jiang, Haiyan Jiang, Hui Jiang, Kun ,172,199 Jiang, Manli Jiang, Wanhong ,158,231 Jiang, Wei Jiang, Xiaoyin Sara...25,116, ,183 Jiang, Yuying Jibrin, Paul G Jimenez, Miguel Angel ,246 Jimenez, Rafael E ,124, ,203,222 Jin, Chunyuan Jin, Jang Jin, Jennifer Jin, Long ,235 Jin, Ming ,218,241 Jin, Yan Jin, Yasuto Jing, Xin Jiron, Kassandra Jo, Vickie Y... 69, 89, 137, ,236, 257 Job, Bastien Jodi, Weidler Joehlin-Price, Amy S ,224 Johannesen, Eric John, George Johncilla, Melanie E...174, ,221 Johnson, Adrienne Johnson, Bruce E Johnson, Joseph Johnson, Joshua Johnson, Laura A ,256 Johnson, Nathalie Johnson, Nicole Johnson, Sarah H ,177,222 Johnson, Sheryl L Johnstone, Sarah E Jolly, Grant A Joneja, Upasana Jones, Andrea ,255 Jones, Andrew D Jones, Carol Jones, Dan...86 Jones, David M ,191 Jones, Derek Jones, Heather H ,240 Jones, Jennifer...55 Jones, Kirk Jones, Martin Jones, Raymond Jones, Ryan D ,173,211 Jones, Terrell Jorda, Merce ,169,...177,203,217,223,239,247 Jordan, Elaine K Jordan, Michael B...60 Jordao, Dercio Jorgensen, Jeffrey L ,206 Jorissen, Robert Jorns, Julie M ,115, ,169 Joseph, Nancy M...108,114,...120,121,166,183,190 Jothishankar, Balaji Joubert, Philippe ,132, ,188 Joung, Je-Gun Jour, George...71,191 Jour, Kimberly Point du ,215 Jouret-Mourin, Anne Jovanovic, Bojana Joyal, Thomas ,239 Juarez-Villegas, Luis E Judkins, Alexander...68, 72 Jug, Rachel ,207,214 Jukic, Drazen M...65 Jung, Chan Kwon Jungbluth, Achim ,168, ,241 Juraszek, Amy Juskevicius, Ridas

344 INDEX K Kabira, Ana-Tereza Kacerovska, Denisa ,248 Kaczmarowski, Amy Kadin, Marshall Kadjacsy-Balla, Andre Kadota, Kyuichi Kadri, Sabah Kagen, Alexander Kahl, Brad S Kahlenberg, Morton Kahn, Andrea...73 Kahn, Ryan Kajdacsy-Balla, Andre Kakar, Sanjay... 49,56,101, ,129,163,166,173,183,184 Kakizaki, Fumie Kaklamani, Virginia G...63 Kakshapati, Trishna Kalhor, Neda...76,154 Kalife, Elizabeth T ,162,168 Kalimuthu, Sangeetha N...190,199 Kalinin, Dmitry ,211 Kalir, Tamara...109,182,224,249 Kallakury, Bhaskar VS ,131, ,177,224 Kallen, Michael E Kalloger, Steve E Kalof, Alexandra Kamal, Mohammed Kamath, Anitha Kambham, Neeraja ,230 Kambouchner, Marianne Kamdar, Kala Kamel-Reid, Suzanne ,...199,240 Kamel, Dhay Kamel, Mohamed K Kamel, Nora N Kamen, Diane L Kaminsky, David B... 22,23,24,... 25,26,27,29 Kaminsky, Ethan...25 Kammerer-Jacquet, Solene-Florence ,247 Kamoun, Malek Kamran, Waseem Kanaan, Yasmine Kanagal-Shamanna, Rashmi..162, ,207 Kanaji, Nobuhiro Kanbour-Shakir, Amal Kandel, Rita A...195,197,236,256 Kandil, Emad Kandukuri, Shivani ,247 Kane, Christopher Kane, Shubhada ,150, ,205 Kane, Yehonatan Kang, Ningling Kang, Yuna Kanthan, Rani Kao, Chia-Sui...123,178,188,243 Kao, Yu-Chien ,236 Kaplan, Cynthia Kapoor, Prashant Kapp, Meghan ,253 Karajannis, Matthias Karam, Jose A Karam, Martin Karamchandani, Dipti M...121, ,243 Karamitopoulou, Eva Karandikar, Nitin J Karim, Sajjad Karnes, R Jeffrey Karnezis, Anthony N ,248 Karnik, Tejashree ,168 Karow, David Karpova, Irina Karrs, Jeremiah Karumanchi, S A Karunamurthy, Arivarasan Kasago, Israel ,131,133 Kashikar, Nilesh Kashiwagi, Eiji ,247 Kashyap, Seema Kaspirkova, Jana Kassem, Maysoun Kassouf, Wassim Kastenbaum, Hannah A Kastner, Daniel L Kasymjanova, Goulnar Katabi, Nora ,150 Kataoka, Kensuke Katara, Rahul ,231 Katava, Gordana Katerji, Hani Katerji, Roula Kato, Ikuma ,235 Kato, Masashi Katoh, Ryohei Katsuki, Naomi Katz, Matthew H ,210 Katz, Ruth L Katzenberg, Jennifer Kaufman, Stuart Kaufmann, Martin Kaul, Karen L...55, 85 Kaur, Jaswinder Kawabata, Yoshinori Kawahara, Kunimitsu Kawahara, Takashi Kawai, Akira Kawakami, Fumi Kawano, Shingo Kazakov, Dmitry V ,194, ,248 Kazemimood, Rossana Keenan, ean O Keeney, Matthew Keeney, Michael G Kefeli, Mehmet Kehr, Elizabeth Keilin, Steven Keiser, Elizabeth Keiser, Michael Keith, Christopher Keller, Christian E Keller, Manuel Kelley, Denise Kelley, Todd W... 66, 162,253 Kellough, David A Kelly, David R Kelly, Karen ,167,187 Kem, Marina ,132,155 Kemp, Christopher Kempen, Leon C van Kendrick, Samantha Kennedy, Claire Kenudson, Mari Mino Kerl, Katrin Kern, Jason Kerndt, Peter R Kerr, Darcy A ,194, ,225,239 Kerr, Kim M ,132 Kerr, Sarah E , 157,164 Kertowidjojo, Elizabeth Ketcham, Catherine...25 Ketterling, Rhett P Keulen, Virginia P Van Keyhanian, Kianoosh Khabaz, Mohamad N Khader, Samer N Khafateh, Youssef Khairallah, Aya Khalid, Asif ,191 Khalifeh, Ibrahim ,213 Khalighi, Mazdak Khalil, Farah Khan, Farhan Khan, Ghazal Khan, Khalid Khan, Saif Khan, Samia ,194,195 Khan, Sheema Khan, Zanobia ,250 Khanafshar, Elham Khani, Francesca ,156,176 Khanlari, Mahsa ,215,227 Khanna, Nehal Khararjian, Armen H Khattab, Ruba Khattak, Aftab Khazai, Laila ,218 Khoja, Hatim Khor, Tze S Khoral, Priya Khoshkrood-Mansoori, Babak ,155 Khoury, JosephD... 49, 153,162,...206,207,208,227,228 Khoury, Thaer ,139 Khurana, Jasvir S ,126,246 Khurana, Kamal K ,141,205 Khurana, Seema Khurana, Ujjawal Khurani, Hetakshi Khurram, Muhammad S...125, 182 Kidder, Ian J Kies, Merril Kilgore, Mark R ,237 Kilic, Ayse I , 217 Kilpatrick, Scott E...99 Kilzieh, Rania Kim, Aeree...71 Kim, Ahrong ,200 Kim, Amy Kim, AnnetteS... 70, 163, 207 Kim, Binnari Kim, Chae Hwa Kim, Daniel J Kim, Eun Kyung Kim, Eun Na Kim, Grace E ,254 Kim, Haeryoung ,255 Kim, Hye Ryun Kim, Hyung-Gyoon Kim, Hyung-Ho Kim, Hyunjae R Kim, Hyunsung Kim, Jaihwan Kim, James Kim, Jeff ,255 Kim, Ji-Yong Julie Kim, Jimin Kim, Jin-Won Kim, Jinah ,197 Kim, Jisun ,211 Kim, Jisup Kim, Jong ,234 Kim, Joo Yeun Kim, Jung-sun Kim, Kyoung-Mee ,221,244 Kim, Kyu-Rae ,248 Kim, Mi Young Kim, Min-Hee Kim, Riyeon Laura Kim, Rob Kim, Seok-Hyung Kim, Seung Tae Kim, Sung Joo Kim, Sungeun...109, 114,116,224 Kim, William Kim, Woo Ho Kim, Yeseul Kim, Young , 208, ,228,252 Kim, Young Keum ,200,244 Kim, Yourha Kimbrell, Hillary Kimler, Bruce Kimmelshue, Katherine Kimura, Kiminori Kimura, Kyosuke Kimura, Takahiro Kimura, Tohru Kindblom, Lars-Gunnar King, Caleb King, Rebecca ,254 Kini, Ameet R Kini, Lata ,231,235 Kini, Usha Kinloch, Mary Kinney, Marsha C Kinoshita, Akira Kinoshita, Fumie Kinoshita, Yoshiaki ,231 Kinzler, Ken Kip, Nefize S Kipp, Benjamin ,255 Kiran, Sayee Kirfel, Jutta Kirkwood, John M Kirsch, Ilan Kirsch, Richard ,175 Kis, Lorand Kishimoto, Hiroshi Kishiwada, Masayuki Kisiel, John B Kiss, Katalin ,150,197 Kisseleva, Tatiana Kissiedu, Juliana O ,243 Kitamura, Yuka Kitlinska, Joanna Kito, Masahiko Kiyokawa, Takako ,250 Kjaer, Susanne K Kleer, Celina G...26 Klein, Eric A Klein, Melissa

345 INDEX Klein, Michael...69,90 Kleiner, David...50 Kleinman, George ,185 Kleinschmidt-DeMasters, BetteK , 185,190 Klevos, Geetika Klimek, Szczepan Klimstra, David S...47, 120,...130,154,221,243 Klingman, David E...88 Klöppel, Günter... 43,130,192 Kluemper, Niklas Kluge, Michelle L ,189 Kluk, Michael ,257 Klump, William Knickle, Corey Knight, Deborah ,174 Knox, Jennifer J ,213,219 Knudsen, Erik S ,220 Knudson, Beatrice Ko, David ,196 Ko, Huai-Bin Mabel ,130, ,198,200,210,219,244,245 Ko, Hyang-Mi Ko, Jennifer ,197 Ko, Young-Hyeh Kobalka, Peter J Kobayashi, Eisuke Kobayashi, Yukihiro Köbel, Martin , 164 Koch, Lisa ,229 Kocher, Jean-Pierre A Kocherginsky, Masha ,201 Kock, Leanne De Kocovski, Linda Kodira, Chinnappa Koebel, Martin ,178,220 Koepsell, Scott A Koga, Hironori Koh, Jiwon Koh, Valerie Koh, Xue-Qing Kohashi, Kenichi Kohno, Takashi Kojima, Motohiro Koka, Madhurima ,139 Kokuho, Nariaki Kolesar, Jill M Kolin, David Kolodgie, Frank Komarow, Hirsh Komissarova, Elena V ,219 Kommoss, Friedrich Kommoss, Stefan Kondo, Tetsuo Kondoh, Yasuhiro Konety, Badrinath ,223 Kong, Beihua Kong, Christina Kongkarnka, Sarawut Konnick, Eric Q Konopka, Kristine Konopleva, Marina Konstantinova, Anastasia M Kontogeorgos, George...33 Konukiewitz, Björn Koo, Jamie Kooby, David ,254 Koong, Albert Kopetz, Scott ,200 Kopp, Jeffrey B...51 Korangy, Elizabeth M Kornacki, Susan Korourian, Soheila Kosari, Farhad ,177, ,230,246 Kosemehmetoglu, Kemal Koshiol, Jill ,255 Kostroff, Karen M Kotzer, Katrina E ,189 Kouba, Erik ,205 Kouji, Hiroyuki Koutlas, Ioannis Kovach, Alexandra Kovtun, Irina V Kowalik, Artur Kozak, Margaret Kraft, Adele O ,205,231 Kragel, Peter ,167 Krane, Jeffrey F... 44, 137,138, ,172,240 Krasinskas, AlyssaM...22, 23, 94,...105,129,143,165,172,...174,191,200,220,243,254 Krasnov, George Kratzke, Robert Kraus, Amanda M Krausz, Thomas ,173 Kravtsov, Oleksandr ,223 Kresak, Jesse L..129,184,190,221 Krigman, Hannah ,158 Krings, Gregor ,162,...168,196,212,215,225 Kris, Mark Krishnamurthy, Savitri ,240 Krishnamurti, Uma ,165,238 Kristiansen, Anna Kristiansen, Glen...98 Krizova, Adriana Kruczek, Kimberly R Krueger, Jo Ellen Krupar, Rosemarie Krysiak, Kilannin Kryvenko, Oleksandr N...177,203, ,223 Kshettry, Varun Kua, Boon Kuba, Gabriela Kuba, Maria G Kubal, Chandrashekhar Kuban, Joshua D Kubilis, Paul Kubo, Takashi Kucuk, Omer Kudaybergenova, Asel Kudlow, Brian...150,159,225,256 Kudose, Satoru ,157,254 Kudryavtseva, Anna ,211 Kuerer, Henry M Kuhar, Matthew Kuhs, Krystle Lang Kuick, Chik Hong Kuk, Cynthia Kulac, Ibrahim Kulkani, Supriya Kulkarni, Girish S Kulkarni, Kirti M Kumar, Chitra Kumar, Kirthi Kumar, Mohit ,231 Kumar, Mukesh Kumar, Priyadarshini ,181 Kumar, Rajiv ,150,204 Kumar, Senthil R Kumar, Sunil Kumar, Vinay...33 Kumar, Vipin ,235 Kumarapeli, Asangi R Kumarasinghe, Priyanthi Kumari, Swati ,151 Kumeda, Cristina Kunder, Christian A ,243 Kunju, Lakshmi P... 22, 107,223 Kunkalla, Kranthi Kunugi, Shinobu Kuo, Frank C ,206,... 07,211,227,241 Kuo, Huai-Ching.146,147,223,245 Kuppachi, Sarat Kurc, Tahsin Kurek, Kyle...68 Kurman, Robert Kurnit, Katherine ,125 Kuroda, Kishio Kurosawa, Sayaka Kurt, Habibe Kurtycz, Daniel , 238 Kuruzar, Gordana Kurzawa, Pawel Kushida, Yoshio Kutys, Robert Kuwaki, Kenji Kuzon, William Kvasnicka, Hans Michael Kwak, Heewon ,198,220 Kwast, Theodorus van der...175, ,246 Kwiatkowski, Fabrice Kwon, Hee Jung Kwon, Sook-kyung ,253 Kwon, Yuri Kyoko, Kurosawa Kyrpychova, Liubov Kyung, Kim Woo L Labarge, Brandon Lacasse, Yves Lacayo, Norman Lackner, Karoline Lacroix, Ludovic Lacy, Antonio Ladanyi, Marc ,112,...131,188,192,193 Ladich, Elena R Laffin, Jennifer J LaFramboise, William A Laga, Alvaro C Lagana, Stephen M...70, 120,...183,184,199,229 Laganosky, Dean Lagoo, Anand S Lagstein, Amir ,225 LaGuardia, Lisa Laguerre, Brigitte ,247 Lai, Chi K Lai, Edwin W Lai, Jinping Lai, Keith Lai, Victoria Lai, Win Shun ,204 Lai, Yue-Yun Laklouk, Israa Lal, Priti ,170,246 Lalonde, Amy ,245 Lam-Himlin, Dora M... 90, 200,255 Lam, Lucia LC Lamaison, Claire Lamarca, Angela Lambert, James R Lambert, Pascal Lambertz, Allyn M Lammert, Craig Lamps, Laura W...22,23,...24,26,27,28,29,103,106, 122,...Honors Tab Lancet, Jeffrey E Landau, Carrie Landau, Michael ,244 Landgraf, Ralf Lane, Carolyn...24 Lange, Jane Langer, Rupert Langone, Anthony Lanigan, Christopher ,237 Lanjewar, Sonali ,251 Lapadat, Razvan ,177,189 Lapinski, James Larios, Jose M Larocca, Luigi M ,239 Larque, Ana B Larsen, Brandon...71 Larsen, Christopher...74 Larson, Alexandra Larson, Brent Laser, Alice Laskar, Siddhartha Laskin, Janessa Laskin, William B Lasota, Jerzy ,241 Lastra, Ricardo R ,125,...143,180,224,240 Laszik, Zoltan ,166,212 Latchminsing, Kerri Ann Latif, Farida Lau, Hubert Lau, Kowk Fai Lau, Ryan P , 231,239 Laucirica, Rodolfo Laughlin, Todd ,192 Laurent-Puig, Pierre Laurent, Camille Lauwers, Gregory E...94, ,157,254 Lauwers, Gregory Y Laver, NoraV...67, 99 LaViolette, Peter S Law, Charles Law, Mark E Lawrence, W Dwayne ,224,226,250 Lawrenson, Kate Lawson, Barrett ,249 Lawson, Diane ,128,...129,158,173,204,231 Layden, Brian Layfield, Lester ,176,248 Lazar, Alexander J... 25, 86, 114,...166,186,191,193,194,195, ,236,241 Lazar, Vladimir Lazarev, Mark

346 INDEX Lazaryan, Aleksandr Lazenby, Audrey J... 22, 26, 73, 128 Laziuk, Katsiaryna ,158 Lazzareschi, Daniel Le, Long Leach, Patrick LeBeau, Shane O LeBoit, Philip Lebwohl, Benjamin Lechpammer, Mirna Lecumberri, Arturo LeDoux, Shawn Leduc, Charles Lee, Anna Lee, Bernett ,211,216 Lee, Boram Lee, Byung-Heon Lee, Chang Hun ,200 Lee, Cheng-Han ,150, ,225,235 Lee, Cheryl T Lee, Chi Hyun Lee, Chung-Han Lee, Chung-Ta Lee, Cleo Lee, Hee Eun ,154,173,...74,188 Lee, Ho-chang Lee, Hwajeong ,129,131, ,190 Lee, Hye Seung Lee, Hyejung Lee, Jack Lee, James Lee, Jeeyun Lee, JeffreyE , 210 Lee, Jen-Chieh Lee, Jennifer LF Lee, Jerome E Lee, John P ,127,138 Lee, Kenneth K Lee, Keun-Wook Lee, Kyoung Bun Lee, Lames Lee, Li-yu Lee, Matthew Lee, Michael ,199,229 Lee, Michelle Lee, Minji Lee, Nathan...25 Lee, Ok-Jun Lee, Peng...123,146,147,223 Lee, Sandra ,250 Lee, Sangjun Lee, Seung J Lee, Seungjae Lee, So Jeong ,200,244 Lee, Thomas D Lee, Thomas K Lee, Victor K Lee, Winston Lee, Xiao-Wen Lee, Yangkyu Lee, Yi-Chien Leeming, Rosemary Lefaivre, Michaela Lefort, Mathilde ,247 LeGallo, Robin D... 23, 214,257 Legesse, Teklu Leggett, Barbara Lehman, Norman Lehmann, Brian Lehrke, Heidi ,183 Lei, Li Leibovich, Bradley C Leich, Ellen Leite, Katia RM ,247 Leith, Kate Leivo, Mariah Z ,223,247 Lele, Subodh M Lemos, Maria M Lennerz, Jochen K ,180 Lennon, Anne Marie Leo, Antonio De ,210 Leon, David Cantu de...176, ,249 Leone, Jose P ,179 Leone, Lisa Leone, Pamela Leong, May Ying Lepe, Marcos LePhong, Christopher D Lerner, Seth P Lerwill, Melinda F , 257 Leslie, LSuzanne Lesluyes, Tom Lespagnol, Alexandra ,247 Lessi, Francesca Lester, Susan C Leteurtre, Emmanuelle Leung, Cheuk Hong Leung, Hong Cheuk Leung, Nelson Leung, Samuel Leval, Laurence de Leventaki, Vasiliki Levi, Angelique Levine, Pascale Levinson, Howard Levinson, Shauna ,184,229 Levy, Bruce...42 Levy, David Levy, Rebecca Lew, Madelyn Lewen, Margaret Lewin, Paul M...26 Lewis, James ,136, ,151,205 Lewis, Jenna ,239 Lewis, Melinda Lewis, Randall Lewis, Robert Lheureux, Stéphanie Li-Chang, Hector Li, Anna Fen-Yau Li, Anqi Li, Arthur Li, Chien-Feng Li, Dan Li, Dehong Li, Faqian ,164 Li, Geling Li, Haocheng Li, Haonan ,219 Li, Hongjie Li, Hui Li, HuiHua Li, Jia Li, Jie Li, Jingyi ,228 Li, K David Li, Li ,251 Li, Qiang Li, Qing K ,131,154 Li, Shaoying ,227,228 Li, Weihong Li, Xiaodun Li, Xiaoqiu Li, Xiaoxian ,169,...195,215,236,237,238 Li, Xin...115,125,140,179, ,237 Li, Xinyan Li, Yanchun ,139 Li, Yiting Li, Yong Li, Yuan ,231 Li, Yunjie Li, Yuping Li, Zaibo ,110,115, ,140,236 Li, Zhongze Lian, Derrick Lian, Fei Liang, Li ,248 Liang, Sharon X Liang, Sheng-Ben Liang, Wen-Yih Liang, Yaoming Liang, Yuanxin Liao, Jie ,219 Liao, Xiaoyan Liao, Zhiming Libe, Rossella Lichner, Zsuzsanna Lichtman, Andrew H Lidke, Diane S Lievo, Ilmo...58 Ligato, Saverio Ligon, Azra H ,185 Ligon, Keith L ,185 Lilo, Mohammed T ,239,240 Lim-Dunham, Jennifer Lim, Beom Jin Lim, Bora Lim, Diana Lim, Huey J Lim, Jeffrey Chun Tatt Lim, Jeffrey CT ,211,216 Lim, JingQuan Lim, Lony Lim, Megan S...27, 89 Lim, Swee Ho Lima, Marcela Saeb Lin, Chieh-Yu...143,168,224,243 Lin, Diana Lin, Douglas Lin, Fan ,130,146,...183,210,221,229,239,255 Lin, Grace Y...131,132,199,219 Lin, Heather ,236 Lin, Henry Lin, Jingmei...190,221,230,257 Lin, Jonathan H ,247 Lin, Leo Lin, Ming-Tseh Lin, Oscar ,238 Lin, Pei ,228 Lin, Peter T Lin, Xiaoqi ,218 Lindberg, Guy Lindberg, Johan Lindeman, Neal I... 66, 81, 178,...184,198,201,211,221,226 Lindsey, Kathryn G Linehan, W Marston , 201 Lingen, Mark Linos, Eleni Linos, Konstantinos Lintel, Nicholas ,225 Lionakis, Michail Lis, Rosina ,223 Lisovsky, Mikhail Litvak, Anna M Litzenburger, Beate Liu, Bei Liu, Bing Liu, Catherine L Liu, Chang Liu, Chen Liu, Cheng ,190 Liu, Eric Liu, Fangfang Liu, Haiping Liu, Haiyan ,130,146, ,210,239 Liu, Huifei Liu, Huiping Liu, Jin Liu, Jonathan TC ,245 Liu, Kai-Yan Liu, Lifang Liu, Lina ,215 Liu, Qiang ,157 Liu, Qingqing ,200,245 Liu, Sandy ,221,243 Liu, Shiguang Liu, Su-Yang Liu, Ta-Chiang ,166 Liu, Tzu-Ying Liu, Weiguo Liu, Xiao Liu, Xiaoying ,245 Liu, Xin ,227 Liu, Xiuli...91,118,121,190,229 Liu, Yan-Rong Liu, Yen-Chun Liu, Ying Liu, Yongjun ,158 Liu, Yuan...115,169,195,215, ,237 Liu, Yuxin ,224,249 Liu, Zach LiVolsi, Virginia A ,242 Ljung, Britt-Marie Llobeta-Navas, David Llombart-Bosch, Antonio Llovet, Patricia Lloyd, Isaac E ,182 Lloyd, Ricardo V... 43, 119,138, ,242 Lo, Amanda E Lo, Bryan Lo, Raymundo W Lo, Winnie Lo, Yungtai Loarer, Francois Le...69 Loayza-Vega, Kevin Lobo, Nazleen C Locatelli, Francesca Lockhart, Shawn...74 Lockley, Michelle Loda, Massimo ,222,

347 INDEX Logan, Suzanna J ,169, ,238 Loghavi, Sanam ,207,208, ,228 Logunova, Valentina Loh, Amos Loh, Eva Loh, Mignon...60 Lombardi, Celestino P Lombardo, Kara A ,120, ,154,163,172,177, 241,247, Lonardo, Fulvio Lone, Waseem Long, Hanan Long, Steven ,240 Long, Theresa Long, ThomasH , 237 Longacre, Teri... 28,47,109, ,178,240 Longatti, Pierluigi Lopategui, Jean Lopes, Beatriz Lopez-Corella, Eduardo Lopez-Guillermo, Armando Lopez-Hidalgo, Juliana E Lopez-Hisijos, Nicolas ,234 Lopez-Ridaura, Ruy Lopez-Santamaria, Manuel Lopez, Jose I Lopez, Juliana E Hidalgo López, Rocio P , 242, 244 Lopez, Tilcia Lordello, Leonardo Lorentz, Adam Lorenzetto, Erica Lorenzoni, Cesaltina Loreto, Christina Di Lorsbach, Robert...60,100 Losada, Daniele M ,203,246 Losada, Hector ,191,255 Lotan, Tamara L ,139,146, ,223,243 Louis, David N...26, 190 Louissaint, Abner Lovane, Lucilia Lowe, Alarice...64 Lowenthal, Brett M Lowy, Andrew M Lozada, John R Lu, Cheng Lu, Chuanyi Mark Lu, Chuanyong Lu, Dan ,141 Lu, Fang-I ,178,216 Lu, Guolan Lu, Haiyan ,118 Lu, Miao Lu, Pin Lu, Shaohua Lu, Shaolei ,154,230 Lu, Xiamon Lu, Xiaomei Lu, Xinyan ,227,234 Lu, Zhichun ,169 Luan, Lan Luc, Jessica GY Luca-Johnson, Javier De Lucas, David R Lucas, Elena ,170 Lucia, M Scott Luconi, Michaela Luebker, Stephen A Luedke, Catherine ,214 Luffman, Christina I Lugli, Alessandro ,175,210 Lui, Weng-Onn Luinetti, Ombretta Luketich, James D Lum, Trina Luna, Eric ,141 Luna, Isabella Lundberg, George D Lunde, John H Luo, Wenyi Luo, Xunda ,126,246 Luo, Yuling ,255,256 Luskin, Marlise Luthra, Rajyalakshmi...155, 162, ,184,200, 207, 212, 234,241 Luthringer, Daniel J Ly, Charles J Lynch, Edward ,246 Lyons, Lisa M Ma, Changqing Ma, Deqin ,236 Ma, Jiao Ma, Julia Ma, Junsheng Ma, Lisa Ma, Sophia Ma, Xiao-Jun...155,183,255,256 Ma, Yihong R MacConaill, Laura E ,226 MacDonald, Scott Macedo, Gabriel S MacGrogan, Gaëtan Machado, Isidro Machado, Rosalie Macher, Bruce Macias, Virgilia ,213 Mack, Philip MacKay, Helen Mackers, Paula Mackey-Bojack, Shannon M Mackinnon, Alexander C...156, ,254 Mackrides, Nicholas MacLennan, Gregory T ,246 Macon, William R Macrae, Finlay ,174 MacRae, Robert M Madabhushi, Anant ,139, ,181,211 Madan, Rashna ,168 Madarnas, Yolanda Madduri, Deepu Madrid, Manuelito A Madrigal, Emilio...40,119, ,182,189 Maeda, Daichi ,225,250 Maedler, Chelsea Maestro, Roberta Maetani, Iruru Magers, Martin J... 40, 119,189 Magi-Galluzzi, Cristina...24,67,... 97,106,202,222 Magliocca, KellyR , 151,257 Magliocco, Anthony ,210,242 Magrill, Jamie Maguire, Aoife Maguire, John A Mahadevan-Jansen, Anita Mahadevan, Navin Mahajan, Akanksha Mahajan, Aparna ,142 Mahalingam, Meera...65 Mahdi, Zaid ,179,243 Mahon, Brett Mahoney, Douglas W Mai, Kien T Maibach, Rudolf Maisonneuve, Patrick Maithel, Shishir ,191, ,254 Maitra, Anirban Mak, Julie ,196 Makohon-Moore, Alvin P Maleki, Zahra ,218,240 Malenie, Renuka Maleszewski, Joseph J...48, 103,...157,166,170,188,189, 257 Malicot, Karine Le Malik, Aatika Malik, Faizan Malik, Prabhat Mallick, Indranil Malm, Ian-James Malone, Carmel Malone, Greg Malpica, Anais... 61,103,110, ,249,257 Mamone, Linda Manam, Monica Mancini, Irene Mancini, Massimiliano Mancini, Maureen G Mancini, Michael A Mandal, Rakesh ,242 Mandell, James W Mandolesi, Alessandra Mandt, Randal L Mangray, Shamlal ,214,248 Mani, Malary ,244 Maniar, Kruti P ,249 Mankaney, Gautam Mann, Steven A ,230 Mannan, Abul Ala Syed Rifat..130, ,158,173,182,190,204,244 Manne, Upender Mannelli, Massimo Mannermaa, Arto Mannu, Claudia Manoj, Namitha Manon, Luis Mansfield, Aaron S ,230,241 Mansoor, Mohammad O Mansoor, Wasat Mansukhani, Mahesh M.. 152,253 Mantilla, Jose G Mantovani, Giovanna Manucha, Varsha Manur, Rashmi Mao, Tsui-Lien Mao, Zhengwei J Marbury, David C Marchand, Joël Tremblay Marchand, Vinciane Marchant, Kandice Marchesi, Raquel Marchevsky, Alberto M Marchio, Caterina Marco, Rex Marco, Vicente ,216 Marcogliese, Andrea N Marcus, Elizabeth A Mardekian, Stacey K Marder, Galina S Maree-Haynes, Ann Marey, Karima I Marginean, Celia ,254 Marginean, Esmeralda C...24 Margolskee, Elizabeth Marguet, Florent Margulies, Kenneth Mariani, Rachel Maric, Dragan Maric, Irina ,153,154 Marino-Enriquez, Adrian...100, ,257 Marino, Danielle Maris, Alexander Mark, Eugene ,188,231 Marker, Daniel F Markow, Michael Markowitz, Arnold Maron, Steven Marotti, Jonathan Marquez, Carolina Dominguez Marsh, J Wallis Marshall, Audrey Marshall, James Marti, Carles Marti, Lola Martignoni, Guido Martin-Guerrero, Idoia Martin, Amanda K Martin, Ben Martin, Blanca Martin, Cara M ,212,213 Martin, Cheyenne Martin, Tina Martinek, Petr Martinez-Cardus, Anna Martinez-Lage, Maria...72 Martinez-Outschoorn, Ubaldo Martínez-Pozo, Antonio Martínez-Ricarte, Francisco Martínez-Sáez, Elena Martinez, Anthony Martínez, Antonio , 253 Martinez, Miguel J Martini, Maurizio Martino, Michele Marton, Elisabetta Marty, Virginie Marusic, Zlatko Maruyama, Yasuhiro Marwah, Annika Maryamchik, Elena Marzo, Angelo M De ,146, ,223,246 Marzullo, Andrea Masand, Ramya ,142,249 Mashlah, Anas ,184 Masia, Ricard ,170 Masih, Aneal Mason, Emily F ,252 Masoudi, Hamid Massoll, Nicole

348 INDEX Master, Stephen Master, Viraj A ,203,204 Mata, Douglas A ,177 Mate, Jose L Mateos, Maria E Matharoo-Ball, Balwir Mathew, Ashley Mathew, Bipin Mathew, Susan Mathews, Stephanie P Mathieu, Romain ,247 Matias-Guiu, Xavier ,150 Matoso, Andres ,172, ,248 Matrai, Cathleen E ,214 Matsioka, Makoto Matsko, Jonee Matson, Daniel ,203 Matsubara, Osamu...33,231 Matsuda, Katsuya Matsumoto, Cal Matsumoto, Masanori Matsumoto, Shinji ,231 Matsumoto, Takashi Matsumura, Mai Matsunaga, Toru Matsuno, Yoshihiro Matsuo, Kosuke Mattia, Anthony Mattis, Aras N ,163,173 Mattis, Daiva Matushek, Scott Matynia, Anna P Maurel, Joan Mauzo, Shakuntala Maxwell, Aaron WP Maxwell, GLarry May, Andrea May, Gary May, Michael May, Rebecca Mayer, Erica Mayer, Ingrid A Mazzaferro, Vincenzo Mazzanti, Chiara McAfee, John L McAlpine, Jessica N ,248 McCabe, Marshall McCall, Chad McCall, Shannon ,183,203 McCarthy, Caitlin ,195 McCarthy, Christine McCarthy, Whitney A...116, ,226 McCarty, Erin ,245 McCauley, Kathleen McClary, Cain...24 McClemore, Jerri McCluggage, W Glenn...61,...164,178,225,248 McClune, Brian McConechy, Melissa McConkey, David McCormick-Baw, Clare ,215 McCready, David McCroskey, Zulfia McCuiston, Austin ,154 McDaniel, Andrew S McDonald, Kelsey McDonald, Timothy M McDonald, William McFarland, Marie McFarlane, Taneisha McGarry, Sean McGinn, John McGough, Richard L McGrath, Kevin ,191 McGregor, Stephanie M McGregor, Thomas B McHenry, Austin McHugh, Jonathan ,190,191 McHugh, Kelsey ,118 McIntire, Patrick J...108,139, ,216,235 McIntyre, John B McIver, Bryan McKay, James D ,212 McKee, Trevor McKelvie, Penelope , 253 McKenna, Barbara J McKenney, Jesse K...47, 98,...122,187,197,201,222 McKenzie, Gordon AG McKinnon, Elizabeth McKittrick, Ian ,256 McLachlin, Meg M McLaughlin, Ray McMahon, Loralee ,222,245 McMahon, Ray...33 McManus, Bruce M McMasters, Richard McMeeken, Emily McNary, Terra J McNeill, Helen McPhail, Ellen D ,192,250 Mecca, Lauren Medane, Sarah ,250 Medeiros, Bruno Medeiros, L Jeffrey ,152,.153,155,162,163,192, 200,206,20...7,208,226,227,228,234 Medina, Karie Meeker, Alan...139,166,246,253 Megna, Daniel Mehra, Rohit ,119,122,...133,175,176,191,223,257 Mehrad, Mitra ,155, ,205,239 Mehrotra, Meenakshi ,200 Mehrotra, Swati ,119,180, Mehta, Arjun Mei, Lily Mei, Zhen W Meignin, Véronique Meis, Jeanne M Meisel, Jane L Meisner, Angela Mejias, Luis Melamed, Jonathan ,146,...147,173,223,231 Melchior, Linea C Melstrom, Laleh Memis, Bahar ,143,165,...172,174,175,191,200, ,254,255 Menard, Chantalle Mendez, Inmaculada Mendiola, Marta Mendoza-Cervantes, Diana Mendoza, Pia ,236,237 Mendoza, Tania Menendez, Clara Menes, Manuel Menezes, Diana Meng, Qing H Mengel, Michael Menke, Joshua Menon, Madhu P ,250 Mentzel, Thomas Mentzer, Steven J Meo, Ashley Di Mercado, Cecilia L Mercan, Ezgi Mercurio, Stephanie Meredith, David M Meric-Bernstam, Funda Merino, Maria J... 55, 133,201 Merzianu, Mihai...91,204 Mesa, Tania Meschter, Steven Mescoli, Claudia ,230 Messer, Jamie Messina, Jane Meszoely, Ingrid Metcalfe, Dean D Mete, Ozgur ,246,257 Mettler, Tetyana N ,218 Meunier, Rashna...25 Meurice, Guillaume Meves, Alexander Meyer, Rosana D Mezhir, James J Mhawech-Fauceglia, Paulette Mian, Badar...122,123,129,177 Miceli, Rosalba Micha, Michal Michael, Claire W Michal, Michal ,193,...194,198,202,203,248,249 Michalova, Kvetoslava , 194, ,203,248 Michalowski, Susan M Michelakos, Theodoros Middha, Sumit ,221 Middleton, Lavinia P Miesbauerova, Marketa Miettinen, Markku M ,151, ,241 Mihm, Martin C Miki, Yasuhiro Mikita, Geoffrey Miles, Rodney Milhem, Mohammed Milikowski, Clara Milione, Massimo Miller, Benjamin Miller, Caitlyn Miller, Catherine Miller, Daniel L Miller, David Miller, Dianne Miller, Dylan V...23,257 Miller, Gregory Miller, James A...125,200,243,247 Miller, Lance D Miller, Michael B Miller, Naomi Miller, Ross A... 45, 114,155,188 Miller, Vincent ,114,115, ,123,126,129,150,172,177,...187,191,192,193,231 Mills, Anne ,119,124,...125,180,214,249,256 Mills, Stacey E ,256 Milne, Katy Milner, Danny A...48, 54, 55, ,238 Milton, Denai Minami, Yuko Miner, Jeffrey H...51 Miner, Thomas J Minerowicz, Christine Ming, Mei Mino-Kenudson, Mari ,112, ,155,188 Mino, Barbara...139,216,248,255 Mira, Beatriz Miraflor, Allen Mirallie, Eric Miranda, Roberto N ,152,228 Miranda, Roberto Mirkovic, Jelena ,226,249 Mirsadraei, Leili ,176 Mirza, Kamran Misdraji, Joseph... 70,73,122,174 Mishra, Sridhar Misra, Sanjeev Mitchell, Duane Mitchell, Jeannette ,220 Mitchell, Richard N Mito, Jeffrey Mito, Kumiko ,210 Mitsuhashi, Tomoko Mittal, Bharat Mittal, Khush Mittal, Pardeep ,191,254 Mittal, Shachi Mittal, Vijay Mittendorf, Elizabeth Miura, Katsutoshi Miura, Shiro Miyai, Yumi Miyamoto, Hiroshi ,245,247 Miyauchi, Akira Mizuguchi, Sarah Mizutani, Yuki Mo, Angela Y Moatamed, Neda A Moch, Holger Mochizuki, Kunio Modesitt, Susan C Modi, Lopa Modi, Nisha Modiano, Nir Mody, DinaR... 69, 108,117,141 Mohammad, Amin Mohammad, Mohammad M Mohammad, Nissreen Mohammad, Ramzi Mohammed, Kareem Hosny Mohammed, Shamayel Mohan, Sanjay R Mohan, Sankar , 231 Mohanty, Abhinita S Mohanty, Sambit K...176,185, ,235 Mohanty, Suravi Mohindra, Shalini Mohler, James Mohlman, Jeffrey S Moignet, Aline Moisini, Ioana

349 INDEX Moiyadi, Aliasgar Mojica, Wilfrido D , 215,243 Molberg, Kyle Molina-Garicano, Javier Molina, Julian R Molina, Maria Molina, Ricardo Molinari, Francesca Mollaee, Mehri Moller, Henrik Moloo, Zahir Momblan, Dulce Monaco, Sara E Moncada, Guadalupe...176, ,249 Moncaliano, Maria C Mondello, Alessia Monga, Varun Monjazeb, Arta M Monnin, Christine Monroe, Robert , 183, ,256 Montaser, Laleh Montecalvo, Joseph ,112 Montecino, Carolina Monteiro, Carmela Montero, Angel Montez, David Montgomery, Bruce ,147 Montgomery, Elizabeth A...110,...121,163,173,200,219,244 Montgomery, Jeffrey S...107,...75,176 Montgomery, Kathleen ,205 Montgomery, Stephen P Montiel, Delia Perez , 176,...202, 203,246,249 Montironi, Carla ,153, ,245 Montone, Kathleen...89 Moo, Tracy-Ann ,196 Moon, James Mooney, Kelly L Moore, Erika M Moore, Margaret Moore, Robert F Morales-Oyarvide, Vicente...110, Morales, Gema N Morales, Linden ,207 Moran, Cesar...76,154 Moran, Sebastian Morash, Chris Moreira, Andre L ,181, 257 Morellas, Vassilios Morello, Brigitte Chebel Morency, Elizabeth ,217 Moreno, Alvaro Moreno, Carlos S ,246 Moreno, Vanessa ,201 Morera, Carolina Silva ,246 Morgan, Elizabeth A...23, 153, , 257 Morgan, Sarah AL Morgan, Terry ,212 Morgan, Todd M Morice, William G Morita, Kohei ,210 Morland, Bruce Morrell, Megan Morris, Don Morrissette, Jennifer Morrissey, Colm Morrow, Monica ,237 Morse, Nicole Moscinski, Lynn ,207,208 Mosiane, Pulane N Moskalev, Evgeny Moskaluk, Christopher A. 181,256 Mosko, Jeffrey D Moslehi, Javid Mosnier, Jean-François Mosquera, Juan Miguel...23,...192,212,223,235, 257 Mosser, Jean ,247 Mostafa, Mohamed Mosteller, Brian Motiee, Angelina Motoi, Noriko ,186 Motoi, Toru ,193 Mott, Sarah L Motte, Nelly Motzer, Robert J Moul, Adrienne Mounajjed, Taofic ,174, ,192 Mouret-Reynier, Marie-Ange Mousavi, Shima Moussa, Sam Mozos, Anna Mrazeck, Karen Msadabwe-Chikune, Susan C..132 Mubeen, Aysha Mudaliar, Vivek Mudini, Washington Muehlenbachs, Atis...74,257 Mueller, Jeffrey.117,143,196,240 Mugabe, Marcellin Mujacic, Ibro Mukherjee, Abir ,167 Mukherjee, Joydeep Mukhopadhyay, Sanjay...45,...106,187,188,257 Mullegama, Sureni Mullen, Chelsey A Mullen, John T Muller, Kristen E ,169,225 Muller, Susan...58 Mulligan, Anna Marie ,116, , 257 Mulligan, Lois Mullins, Keith Mully, Thaddeus Munkarah, Adnan R Munsell, Mark Muppa, Prasuna ,120, ,246,250 Muqbil, Irfana Muraki, Takashi ,172,...174,175,191,220,254, 255 Murali, Rajmohan ,150 Muralitharan, Sharmini Murata, Yasuhiro Murdock, Tricia Murga-Zamalloa, Carlos...127, Honors Tab Murphy, Kathleen M Murphy, Stephen J Murray, David L Murray, Melissa ,169 Murray, Sarah S Murro, Diana Murugan, Paari ,217,223 Musa, Stephen I Musallam, Sami G Mustafa, Sara Musulen, Eva Mutch, David G Mutuiri, Anderson Muvunyi, Jean Baptiste Muzikansky, Alona ,129 Muzzafar, Tariq Mwaba, Catherine Mwala, Kabisa Mweemba, Isaac Myers, Jeffrey L ,119,122 N Naab, Tammey J Nabeshima, Kazuki ,231 Nadasdy, Tibor...74,103 Nademanee, Auayporn Nadji, Mehrdad ,249 Nael, Ali ,208,214 Nafa, Khedoudja Nagamos, Rochelle Nagales Nagarajan, Priyadharsini...118, ,191,241 Nagayasu, Takeshi Nagendran, Jayan Nagzarkar, Sudaiv Nahas, William C Naidoo, Jarushka Naik, Padmaja Naina, Harris Naini, Bita V... 70, 138,190, ,229,255 Nair, Asha ,220 Nair, Navya Nair, Suresh Nair, Vidhya Naiyer, Nada Naizhen, Xu ,201 Najafian, Behzad Najarian, Robert M...24 Najera, Leticia Najjar, Saleh N Najmuddin, Mufaddal Nakagawa, Mayumi Nakai, Tokiko Nakajima, Naoki Nakajima, Tomoyuki Nakamura, Sayuri ,155 Nakanishi, Kuniaki Nakasaki, Manando Nakashima, Masahiro Nakashima, Megan O , 244 Nakazawa, Tadao Nakhleh, Raouf E... 99, 156,157 Nakhleh, Raouf...82,257 Naklowycz, Al Nalbantoglu, ILKe ,183, ,230, 257 Nalesnik, Michael A , 190 Nam, Anna ,252 Nam, Soo Kyung Namer, Brenda L Nandeesh, N B Nanus, David M Naporo, Simon Naqvi, Asghar ,189 Narasimhamurthy, Mohan Nardi, Valentina ,112,253 Narick, Christina M ,205, ,238 Narula, Navneet Nash, Rebecca ,165,255 Nasir, Aqsa ,230,246 Nasir, Nur Diyana Binte Md Nason, Katie S Nasr, Christian Nasr, Michel Nasr, Samih H ,182 Nasri, Elham ,234 Nassar, Aziza Nassiri, Mehdi ,163,206 Nast, Cynthia C...74, 182 Natkunam, Yasodha Natu, Ashvini Naum, Bruna Naumaan, Anam Navale, Pooja ,182 Navarro, Alba Nayak, Anupma Nayar, Ritu... 24,142,164,217, ,239,249 Nazeer, Tipu...122,123,127,129, ,224,251 Nedjadi, Taoufik Neel, Benjamin Neely, Cameron ,236,237 Neff, Jadee ,241 Neil, Kevin Neill, Stewart ,185 Nejati, Reza Nelis, Mischa Nelson, Ann Marie...26 Nelson, Jonathan Nelson, Peter S , 147 Nelson, Rebecca Neppl, Christina Nesi, Gabriella ,243 Nestler, Rick Neto, Antonio G ,198 Neto, Raymundo Azevedo Netto, George J... 85, 87, 122,...125,146,175,176,177,247 Neumeister, Veronique Newman, Marsali Newman, Scott Newman, Travis...24 Newsom, Kimberly J ,183 Neyaz, Azfar Ng, Cedric Chuan Young...113, 169 Ng, Charlotte K ,211 Ng, Dianna Ng, Tony...113,150,180,225,235 Ngadiman, Sutini Nguyen, Aivi Nguyen, Doreen Nguyen, Kien Nguyen, Kim Nguyen, Luong Nguyen, Lynh ,153 Nguyen, Van T Nguyen, Vu Ni, Ruoyu Ni, Shujuan Ni, Yunbi Niblet, Angela Nichols, Kim Nicholson, George

350 INDEX Nicka, Catherine ,181 Nickeleit, Volker Nickless, David Nickols, Hilary Nicol, Christopher Nie, Kui Nielsen, Gunnlauger Petur...52,... 99, 110, 193, 194 Nielsen, Torsten ,248 Niero, Monia Niki, Toshiro Nikiforov, Yuri ,164,184 Nikiforova, Marina N...44, 122,...138,142,184,191,200 Nikowitz, Janet Niland, Joyce Nine, Jeffrey S Ning, JIng ,241,248 Nirschl, Jeffrey Nishikawa, Toshio Nishino, Ha Nishino, Michiya ,116 Nishioka, Hiroshi Nitta, Hiroaki ,115,140 Niu, Nifang Niu, Shuang Nobori, Alexander Nodit, Laurentia Noë, Michaël Noel, Jean-Christophe Nofech-Mozes, Roy Nofech-Mozes, Sharon...114, ,216 Nohle, David G Nolan, Amber...40 Nolan, Sheila M , 209 Nolte, David A Nomani, Laila ,118 Nonaka, Daisuke ,171,244 Nonell, Lara Nonogaki, Hirofumi ,176,247 Noon, Aidan P Nora, Virgilita Norgan, Andrew Normand, Charles Norton, Larry ,237 Nosé, Vania... 28,47,138 Notta, Faiyaz Nour, Sherif G Nout, Remi A Nowak, Jan A ,157 Nowak, Jonathan A ,254 Noyes, Lauren Nozad, Sahar ,115,177 Nozaka, Hiroyuki Nucci, Marisa R...22, 110, ,178,225 Nucci, Marisa...23 O O Brien, Roisin O Broin, Anne Marie O Bryan, Brittaney E O Callaghan, Daniel O Crowley, Jacqui Barry O Donovan, Maria O Gorman, Maurice RG O Hare, Kevin O Leary, John J ,212,213 O Leary, Matthew O Loughlin, Mark O Malley, Dennis P...88, 127, ,229 O Malley, Margaret O Neil, Maura O Neill, William C O Neill, Zachary O Regan, Esther O Regan, Ruth O Riain, Ciaran O Sullivan, Roderick J O Toole, Sandra O Toole, Sharon ,212,213 Oak, Jean ,206,227 Obadofin, Omobolade Obaid, Nourah M Obeng, Rebecca C ,191 Oberley, Matthew Ochiai, Atsushi Ochoa, Imogen Sharkey Oda, Yoshinao...188,193,199,231 Odukoya, Abdullateeph A Oduro, Kwadwo ,167 Odze, Robert D...109,190,198,244 Offermann, Anne Ogan, Kenneth ,254 Ogata, Sho Ogawa, Hiroshi Ogawa, Masumi Ogilvie, Travis Ogino, Shuji Oguntebi, Emmanuel E Ogurtsova, Aleksandra ,235 Oh, Soo-young Ohashi, Kenichi ,235 Ohbayashi, Chiho Ohgami, Robert...70,152,...154,206,208,227 Ohike, Nobuyuki Ohnoda, Takashi Ohori, N Paul... 69, 138,164 Oishi, Naoki Ojanguren, Isabel Ojo, Olusegun S Ok, Chi Y ,207 Okamura, Keisuke Okaniwa, Shinji Okimura, Masato Okonkwo, Nkechi Okuda, Masaya Okudela, Koji Okuma, Tomotake Olah, Friday Olevian, Dane Olgaard, Ericka... 23,159,257 Olgac, Semra Oliva, Esther...26,27,28,100,110,...111,125,150,164,179,225,250 Oliva, Jorge de la ,153 Oliveira, Andre ,235 Oliveira, Gabriel LP ,203,246 Oliver, Bill Oliver, Dwight Olivier, Magali Olofson, Andrea ,245 Olsen, Randall Olson, Gwyneth Olson, Jeffrey J Olson, Mathew T Olteanu, Horatiu Omarzai, Yumna Ombrello, Amanda Omman, Reeba Ondič, Ondrej , 203, 249 Ondracek, Rochelle Payne Onega, Tracy Onernek, Ayse Mine Ong, Menchu ,234 Onisko, Agnieszka ,237 Onodera, Courtney Onozato, Maristela Oprea-Ilies, Gabriela Opyrchal, Mateusz ,139 Orain, Michèle ,132,155 Orazi, Attilio... 99,162,227,252 Ordi, Jaume ,168 Ordobazari, Atousa ,217,249 Ordulu, Zehra ,225 Ormenisan-Gherasim, Claudia..246 Orr, Brent...41 Orsi, Nicholas Ortiz-Martinez, Fernando Ortiz, Juan Osamura, Robert Yoshiyuki...43 Oshilaja, Olaronke Oshima, Kiyoko.142,229,254,255 Oshiro, Hisashi Osmani, Lais ,218 Ostry, Avrum J Osunkoya, Adeboye O...92, 98,...106, 122, 123,143,165,177,...203,204,223,246 Ota, Hiroyoshi ,199 Otani, Tomoyuki Otero, Dennise E Otero, Jose Otis, Christopher N Ott, Eva Ottesen, Rebecca Ou, Joyce ,125,168 Ouairy, Adrien Ouseph, Madhu Overman, Michael Oweity, Thaira Owen, Scott R Owens, Christopher L Owens, Jordan Magee Ownbey, Robert T Owonikoko, Taofeek K Oza, Amit ,250 Oza, Nikita S Ozerdem, Ugur ,169,236 Ozkaynak, Mehmet Ozluk, Yasemin Ozogul, Ece P Pabedinskas, Dana Padera, RobertF...48, 71, ,186,189 Padgett, Jessica Padmanabhan, Vijayalakshmi ,142,143 Paessler, Michele E...60, 100, , 257 Pagan, Carlos Pagano, Nico Pai, ReeteshK...56, 157, ,200,244 Pai, Rish K... 22, 23, 94, , 167,174 Pai, Trupti Paik, Seung S Paine, Robert R...59 Paintal, Ajit ,249 Pakuts, Benjamin Pal, Sumanta...122,123,129,177 Palacios, Diana Palanisamy, Nallasivam...133,177 Palapattu, Ganesh S ,176 Palazzo, Juan P ,221 Palisoc, Maryknoll Pallavajjalla, Aparna Palma, Angela De Palme, Carsten E Paludo, Jonas Pambuccian, Stefan ,118, ,129,132,146,165,177,209, ,217 Pan, Liuliu Pan, Xiaochuan Pan, Yongsheng Panarelli, Nicole C...73, 157 Panaretakis, Theocharis Panchal, Hinaben J Pandey, Santosh ,235 Pandita, Ajay ,231 Paner, Gladell P... 46, 107,124,146 Pang, Brendan Pang, Judy ,116,158 Pankajakshan, Chandroth Navin Pannunzio, Andrea Panse, Gauri Pantanowitz, Liron...23,128, ,181,217 Pantavaidya, Gouri Pao, Andy Paoletti, Costanza Papachristou, Georgios I...142,191 Papadodima, Stavroula Papadopoulos, Nickolas...164, 175 Papaleo, Natalia F , 251 Papanastatiou, Anastasios D Papanikolopoulos, Nikolaos P Papaxoinis, George ,244 Papenhausen, Peter R Paquette, Cherie ,125, ,226,249 Parameshwaran, Vishnu Pardeshi, Vishakha Paré, Guillaume Pareja, Fresia...136,151,168,169 Parian, Alyssa Parimi, Vamsi ,146, ,208,245 Park, Do Joong Park, Do Youn...198,200,244,254 Park, Emily ,255,256 Park, Ha Young ,221 Park, Hyunjin Park, Jason Y ,209 Park, Ji-Weon Park, Kay... 75,164,250 Park, Kyung ,210,211, ,235 Park, William KC Park, Won-young Park, Woong-Yang

351 INDEX Parkash, Vinita... 22,61,137,...179,180 Parker, Kwabna Parks, W T Parra-Herran, Carlos ,114, ,147,178,216,225,226,257 Parra, James Parry, Susan Parsons, Kellogg Parvinnejad, Nikoo Parwani, Anil... 22,42,102,108,...115,128,180,181,189,246 Pasaoglu, Esra Pasche, Boris Paschke, Ralf Pasic, Maria Pastoret, Cedric Patel, Ami Patel, Dominic Patel, Jay L ,206 Patel, Kepal N Patel, Ketan Patel, Keyur P ,163,184,...200,206,207,226,241 Patel, Mihir Patel, Natalie ,236 Patel, Nikhil Patel, Nisha Patel, Nupam ,253 Patel, Rajiv M...23, 25,95, 197, 257 Patel, Sandip Patel, Sanjay ,127 Patel, Shobhanaben J Patel, Shweta ,246 Patel, Smita ,151,180 Patel, Snehalkumar B Patel, Tejal ,252 Patel, Vatsal ,221 Patel, Viren ,126 Patell-Socha, Farah Patey, Martine Pathak, Ravi R Patil, Asawari ,204,205 Patil, Datta Patil, Deepa T , 109,163,...173,198,200,221 Patil, Ninad M ,249 Patil, Pallavi A ,163,186 Patil, Priyanka Patil, Suhas Pattaras, John G Pauli, Chantal ,212 Paulsen, Erika Paulsen, John D ,239 Paulson, Vera Pavlisko, Elizabeth N ,188 Pawlik, Timothy Payne-jameau, Yolanda Payne, Sakeena Peace, Janais Pearce, Shane M ,146 Pearlman, Rachel ,174 Pease, Garrison ,173 Peciarolo, Antonella Pederson, Holly J ,195 Pederzoli, Filippo Pedron, Serena Peevey, Joseph Pei, Lin ,234 Pei, Zhengtong Peikert, Tobias ,188,230 Peiro, Gloria Peker, Deniz Pekmezci, Melike ,194,215 Pelland, Kevin T Pellegrinelli, Alessio Pelletier, Daniel J ,129 Pellise, Maria Pelosi, Giuseppe Pelton, Ashley Pemmaraju, Naveen Pena, Lourdes ,246,249 Pena, Maria Del Carmen Rodriguez...125,175,176,247 Penault-Llorca, Frederique...125, ,196 Pence, Isaac J Pendse, Avani Peng, Limin ,238 Peng, Xuan ,139 Peng, Yu-Ching Peng, Yue Pennella, Antonio Penny, Will Pentecost, Brian T Penzias, Gregory Pepe, Carmela Pepper, Daniel...54 Pepper, Kristi Pepper, Michael Peralta-Venturina, Mariza de ,253 Pereira, Daniela Pérez-Míes, Belén Pérez-Montiel, Delia Perez, Francisco Perez, Julia Mendoza ,246 Periakaruppan, Ramayee Perner, Juliane Perner, Sven ,205 Pernicone, Elizabeth Perret, Raul Perrino, Carmen ,201 Perrone, Anna Myriam Perry, Anamarija Perry, Ann E Perry, Arie...72,87,101,190,194 Perry, Cynthia Perry, Kyle D ,193,220 Pesci, Anna ,179,250 Pestalozzi, Bernhard Peterson, Jason D ,191, ,256 Petros, John A Petrovic, Ivana Petrowski, Kelly Petrozza, Vincenzo Peyronnet, Benoit ,247 Peyster, Eliot Pezhouh, Maryam ,121,...163,166,173,200,219,244 Pezzuto, Federica Pfarr, Nicole Pfeffer, Lawrence Pfeifer, John D Pfisterer, Jacobus Pham, Trinh Phelan, Sine Philip, John Sir ,217,239 Philip, Philip Philips, Sharon Phillips, Joanna Piao, Jin Piazza, Yelena ,239 Picarsic, Jennifer...60 Picci, Piero ,235,236 Piccoli, Anthony L Pichardo, Janine Picken, Maria M... 67, 124,146, ,180, 245 Piedras, Diana Pierce, Kirsten Pietanza, Maria C Pietenpol, Jennifer Pigeon, Marc-Antoine Piha-Paul, Sarina A Pihan, German Pijuan, Lara Pileri, Stefano Pillai, Raju ,241,251 Pillai, Vinodh Pillappa, Raghavendra Pilley, Jacob Pina-Oviedo, Sergio Pincus, Jennifer ,140 Pinheiro, Celine M Pinheiro, Katherine Pinho, Daniella Pinkus, Geraldine ,252 Pinnaduwage, Dushanthi...111, ,216 Pins, Michael R Pintille, Melania Pinto, Amanda C Pinto, Andre ,225,235, ,249 Piris, Adriano Piris, Miguel Pirzada, Amrah Pisano, Annalinda Pisapia, David J...93,167,...192,212,235, 257 Piscuoglio, Salvatore Pistillo, Maria Pia Pitman, Martha B... 26, 64, 116,117 Piton, Nicolas ,230 Pitt, Susan Pittaluga, Stefania ,253 Pittman, Meredith ,191 Piulats, Josep Maria Pivovarcikova, Kristyna ,203 Pizzato, Cristina Pizzi, Marco Pizzo, Salvatore Plagov, Andrei Planas, Ramon Plant, Pamela Plata, Adriana Plaza, Diego Plaza, Jose A Plesec, Thomas ,173, ,221 Plotkin, Anna Plotkin, Scott Plummer, Regina M Podoll, Mirna B ,178,238 Podoltsev, Nikolai Pogoriler, Jenny Pohthipornthawat, Natkrita Poirier, John T Poisson, Laila M Poklepovic, Andrew Pokorny, Morgan Pokrovsky, Anatoly Polanco, Evelyn Carolina Polano, Maurizio Poli, Giada Polito, Humbert Polka, Avery Pollack, Aron Z Pollack, Ian F Polski, Jacek Polydorides, Alexandros D...23,...103, 120,130,190,198,...200,210,219,245, 257 Pomel, Christopher Ponce, Jordi Ponce, Jose J Ponder, Teresa Ponsky, Lee Pontecorvi, Alfredo Pool, Christopher Pool, Mark Popnikolov, Nikolay Poppiti, Robert ,223 Poropatich, Kate ,231 Port, Jeffrey L Porter, Teresa C Porteus, Cory Portillo, Armando Del ,219 Post, Steven Poster, Craig Poullot, Elsa Poulter, Melinda D Pourabdollah, Maryam ,227 Poveda, Julio C Powell, Simon Powell, Suzanne Z... 22, 72, 184 Powers, Celeste N...26, 165, ,231 Powles, Carrie Pozdnyakova, Olga ,162, ,207,227 Pozo-Yauner, Luis del Prabhash, Kumar Pradeep, Yashodhara Pradhan, Dinesh ,122, ,141,236 Prajapati, Shyam ,128, ,182,189 Prakash, Sonam... 24,184,257 Prandi, Davide Prasad-Hayes, Monica Prasad, Anil Prasad, Ashish Prasad, Manju L ,239 Prasad, Rajeev Prasad, Shilpa Prathibha, Saranya ,246 Prats, Mariana Moreno Prayson, Richard A... 89, 99, 100, ,186 Prendeville, Susan ,246 Presnell, Sharon Preston, John Priamo, Francesco Price, Matt A Prichard, Jeffrey W , 237 Priemer, David S ,189, 222 Prieto, Victor G...71, 95,...118,137,186,191,208,241 Primmer, Michael P Priore, Salvatore Priori, Roberta

352 INDEX Prisciandaro, Elena Pritchard, Colin Pritt, Bobbi S... 23,48, 72, 74,103, ,257 Prochaska, Michael A Procop, GaryW... 74,106, 137 Proe, Lori A Provenzano, Elena...99 Pruthi, Deepak K Przybycin, Christopher ,201, ,257 Puccio, Ignacio Puggioni, Chiara Pulido, Jose Pulitzer, Melissa Pullarkat, Sheeja T Pullman, Eli Pullman, James M Punzi, Alessandra Purushothaman, Sonya Pusceddu, Sara Pushker, Neelam Putra, Juan ,183,230 Pytel, Peter Q Qasem, Shadi A Qian, Zhirong Qin, Jia Qin, Ya-Zhen Qing, Xin Qiu, Hong Qiu, Xiaoming Qu, Hong Qu, Zhenhong Quade, Bradley J...22, 23,...110,164,225,226 Quddus, M Ruhul ,116,...125,162,168,177,224,250 Quesada, Andres E Quezado, Martha M Qui, Hong Quick, Charles M...23, 88,...178,179, 222,248,249, 257 Quigley, Brian ,220 Quinn, Courtney E Quinones, Alexander K Quintal, Maisa M Quinton, Paul Quirke, Philip Quitllet, Francesc A Qureshi, Sajid R Raab, Stephen ,132, 240 Raad, Rita Abi ,239 Rabban, JosephT...61,92,...162,164,178,179, 196,224 Rabinovitch, Peter S ,173 Raca, Gordana Racila, Emilian Racine, Étienne Raciti, Patricia Rae, James M Raess, Philipp W Raffeld, Mark Raghavendra, Ashwini Rahaman, Jamal Rahi, Hamed Rahimi, Mahdi Rahimi, Nader Rahmanto, Yohan Suryo Rahmy, Amal Rai, Harpreet Rais-Bahrami, Soroush ,204 Raj, Rishi ,231 Rajasegaran, Vikneswari...113,169 Rajeshwari, Madhu Rajoria, Gaurav Rajyalakshmi, Luthra Rakislova, Natalia ,245 Raleigh, David Ralston, Jonathan S Ram, Rosalyn Ramachandran, Raga...23,257 Ramadwar, Mukta Ramakrishna, Rohan Ramalingam, Preetha...164,...224,249 Ramani, Nisha S Rambau, Peter F Ramella, Aman218 Ramirez-Santrich, Cecilia...153,163 Ramirez-Villar, Gema L Ramirez, Angela Sanguino Ramirez, Daniel C Ramirez, Yuly Ramis-Zaldivar, Joan Enric Ramjeesingh, Ravi Ramkissoon, Shakti H ,114,...115,122,123,126,129,150, ,177,187,191,192,193, 231 Ramos-Oliver, Irma Ramos, Benjamin D Ramos, Robert Ramsey-Goldman, Rosalind Rane, Swapnil ,130,150 Rangan, Aruna ,250 Ranganathan, Sarangarajan Range, Danielle Elliott Rangel, Laureano J Ranson, Marie ,137 Rao, Arundhati ,119,...157,171,207,215,249 Rao, Deepthi...120,130,221,243 Rao, Jianyu Rao, Koneti Rao, Lokinedi Rao, Priya... 67,124,133,177 Rao, Rema A...171,192,212,240 Rao, Sambasiva ,219 Rao, Uma NM Rao, Veena N Raparia, Kirtee... 45,154,186,231 Raphael, Solomon Rashid, Asif ,192,210 Rassaei, Negar Rassidakis, George Rastgoo, Nasrin Rastogi, Prerna Rathkopf, Dana E Ravaud, Alain ,247 Ravetti, Jean Louis Ravindran, Aishwarya ,253 Rawish, Kojo Raychaudhuri, Pradip Razavi, Pedram Rea, Bryan Reading, Noel S Rech, Karen L ,192 Rechsteiner, Markus Reddy, Avinash K Reddy, Opal L Reddy, Vijaya B ,180, 257 Reder, Nicholas P...111, 167,178,237,245 Redig, Amanda J Redman, Mary W Redmond, David Reece, Donna Reed, Robyn Reeve, Jeff Reeves, Ward ,143,240 Rehder, Catherine Rehman, Abdul Rehman, Aseeb ,123 Rehrauer, William ,114, ,172,242 Reichard, Kaaren K ,227 Reid, Michelle D... 99, 130,142,...143,165,172,174,175,191,...200,220,254,255, 257 Reinig, Erica F ,208,227 Reis-Filho, JorgeS...63, 136,...150,151,168,169,211 Reis, Gerald Reis, Sabrina T Reisenbichler, Emily ,162 Reith, John D... 22, 23, 99, 197 Rekhi, Bharat Rekhtman, Natasha ,112,...154,156,188,257 Remotti, Helen E ,183, ,219,229 Ren, Hongzheng Ren, Kevin Yi Mi ,174,196 Ren, Qinghu Ren, Rongqin ,205,231 Ren, Shuyue Renaudin, Karine Renda, Valentina Rendi, Mara H Renne, Giuseppe Renne, Salvatore Rennspiess, Dorit Renouf, Daniel J Renshaw, Andrew Resetova, Erika Resnick, Murray B...25, 29,...120,121,172,195,248 Reuss, David E Reuter, Victor E...26, 107,...122,123,133,175,176,201 Revelo, Monica P Revetta, Frank Rex, Douglas K Reynolds, Jordan P , 117, ,218 Reynolds, Stephen Rezaee, Neda ,240 Rezaei, M Katayoon Rezk, Sherif Rhines, Laurence D ,236 Riad, Sara Ribalta, Teresa Ribeiro, Agnes Riben, Michael W Ricceri, Valeria Ricci, Claudio Ricci, Costantino Rice, Kevin R Richard, Hope Richard, Scott D Richards, Stephanie ,139 Richardson, Aida Richardson, Mary S...24,26 Richon, Catherine Ricketts, Christopher Rickman, David S Ricks-Santi, Luisel J Ridaura-Sanz, Cecilia Riddell, Robert H...56, 110, ,244 Ridder, Gustaaf de Riddle, Nicole D...25,27 Riedel, David Rieder, Florian Righi, Alberto ,235,236 Righi, Simona Rijk, Anke F Rijn, Matt van de ,212 Riley, Meghan Rimm, DavidL... 26,83, 240 Rimsza, Lisa Rinehart, Elizabeth M Ring, Kari Rios, Alyicia Rioux-Leclercq, Nathalie...201, ,247 Rishi, Arvind Ristow, Kay M Ritterhouse, Lauren... 40,112,254 Rittscher, Jens Rivera-Colon, Glorimar Rivera, Michael ,247 Rizo, Annnaliza Rizvi, Naiyer Rizzo, Stefania Ro, JaeY...101, 114,170,235 Roa, Juan Carlos ,191,255 Robert, MarieE... 26, 89,163 Roberto, Gamez G Roberts, Amity L Roberts, Daniel E Roberts, Drucilla J Roberts, Jordan A Robertson, Scott ,173 Robertson, Susan J Robin-Radosevic, Nina Robinson, Brian... 90,103,124, ,176,192,200,212,223,243 Robinson, Cemre Robinson, Daniel Robinson, Robert ,143,151 Rocca, Carlo Della Rocha, Ruana M ,203,246 Rock, Colleen Roden, Anja C...91,105 Roden, Anja C ,131, ,157,188 Rodig, Scott...87 Rodrigues, Daniel Nava Rodriguez-Alvarez, Francisco J.136 Rodriguez-Canales, Jaime...139, ,255 Rodríguez-Gómez, Adriana Rodriguez-Justo, Manuel Rodriguez-Urrego, Paula A Rodriguez-Zarco, Enrique Rodríguez, Eva

353 INDEX Rodriguez, FaustoJ...53, 67,...72, 101, 166,178,185,190 Rodriguez, Ingrid M ,222 Rodriguez, Leonardo Rodriguez, Olga Rodriguez, Pablo Rodriguez, Sonia Rodvold, Jeffrey J Roe, Catherine J Roehrl, Michael Rogers, Thomas Roggin, Kevin Roggli, Victor L , 155 Rogman, Alberic Roh, Michael... 23,99,257 Roig, Ignasi Rojas, Claudia ,239,255 Rojo, Federico Roland, Lania Rolón, Rebecca M Marrero Roma, Andres A...91, 110, ,180,237 Roman-Holba, Samara Roman, Amanda Roman, Benjamin ,171 Romero, Eduardo Romero, Maria E Rominger, Rachel E Roncaioli, Justin L Roncal, O Roncella, Silvio Ronen, Shira ,176 Rong, Juan ,208 Ronnett, Brigitte M ,226 Ronquillo, Nemencio Rook, Alain Rooper, Lisa M ,112,240 Root, Matthew Roper, Edward Roquiz, Woodlyne Rosa, Gabriela Rosa, Marilin Rosa, Stefano La... 43,171,192 Rosado, Flavia...68 Rosati, Rachele Rose, Gary ,139 Rose, Laurel Rose, Sarah Rosen, Devin Rosen, Lauren E Rosen, Milan Rosen, Seymour ,182 Rosenbaum, Jason N ,172 Rosenbaum, Matthew W...109, ,117, Honors Tab Rosenberg, Andrew E...194, ,235 Rosenberg, Jonathan E Rosenblatt, Paula ,139 Rosenblum, Marc ,236 Rosendahl, Isabel Rosenthal, Barbara Rosenwald, Andreas Roshal, Mikhail Rosner, Inger L..146,147,223,245 Ross, Aidan Ross, Ashley E ,146,223 Ross, Dara S Ross, Jeffrey S... 81, 109,112,...114,115,116,122,123,126,...127,129,150,172,177,187,...191,192,193,224,231,251 Ross, Merrick I Rossi, Esther Diana...69,117, , 239 Rossi, Michael Rossi, Roberta Rossi, Sabrina ,185 Rosty, Christopher...94,109, ,190,200 Roth, Christine G Rothberg, Paul G ,192,245 Rotimi, Olorunda Rotondo, Fabio Rotterova, Pavla ,203 Rouhi, Omid ,185 Roulston, Diane Roupret, Morgan Routbort, Mark J ,155,162,...163,184,200,206,207,227, ,241 Rouzbahman, Marjan ,250 Rovira, Jordi Rowan, Daniel ,255 Rowe, J. Jordi... 90, 99, 237 Roy-Chowdhuri, Sinchita...45,...99,239 Roy, Madhuchhanda Roy, Paromita Roy, Somak... 42,122,184 Royal, Richard E Roychoudhury, Sudarshana Ruan, Guo-Rui Ruano, Ana Rubenstein, Michael Rubin, Brian P... 25, 119,151,...165,168,181,194,197, 213 Rubin, Mark A... 97, 192,210, ,223,235 Rubino, Anthony ,183,184 Rubinson, Douglas A Rubinstein, Paul Rubio, Belen L Rubio, Carlos A Rubio, Isabel T ,216 Ruby, Kristen N Rudan, John Rudin, Charles M Rudnick, David Rudomina, Dorota Ruff, Heather Rugge, Massimo ,230 Ruggieri, Pietro Rugwizangoga, Belson Ruiz-Cordero, Roberto Ruiz, Jeanette Ruiz, Nuria Ruminy, Philippe Rundstedt, Friedrich-Carl von Rupcich, Christine ,141 Rusch, Valerie Rüschoff, Josef Rush, Natalia ,184,...Honors Tab Rushton, Kristen Russell-Goldman, Eleanor Russell, Donna Russell, Maria C Russo, Joshua Ruterbusch, Julie J Rutgers, Joanne K Ruttle, Carmel Ruzinova, Marianna B , 257 Ryan, Shawnia Rychly, Boris S Saad, Ali G ,185,192,...193,214,222,240,252 Saad, Heba Saadeh, Feras Abu Saavedra-Martinez, Jenny Saavedra, Olivia Sábado, Constantino Sabari, Joshua K Sabatino, Antonio Di Sabattini, Elena Sabourin, Jean-Christophe...155, Sabra, Mona Sachak, Taha ,183 Sacher, Adrian Sacks, Barry A Sacks, Wendy Sadigh, Sam Sadimin, Evita Sadow, Peter M , 257 Sadowinski-Pine, Stanislaw Sae-Ow, Wichit Saeed-Vafa, Daryoush Saeed, Faisal ,176,229 Saeed, Omer ,194 Saez, Carmen Safdar, Nida Saffitz, Jeffrey E...27 Saglam, Ozlen Saharti, Samah ,217 Sahasrabuddhe, Vikrant Sahin, Aysegul A...94, 139, ,215,216 Sahoo, Debashis Sahoo, Sunati Sahu, Divya Said, Samar Sailer, Verena , 212 Saito, Michihiro Saito, Norio Saito, Ryoko Sajjan, Sujata ,132 Sakhdari, Ali ,209 Sakic, Antonija Sakr, Hany ,125,251 Sakr, Lama Sakr, Sharif Saksena, Annapurna Sakuyama, Naoki Sala, Margarita Salama, Mohamed ,162,206 Salamat, M Shahriar ,119, Salami, Simpa S Salaria, Safia Salaverria, Itziar Saleeb, Rola ,202,247 Salem, Alireza ,228 Salem, Fadi ,254 Salem, Ronald Salem, Samira AM Salfi, Nunzio CM Salib, Christian ,256 Salibay, Christine J Salimian, Kevan Salomao, Diva Regina...53, 186 Salona, Beklaswar ,231 Salto-Tellez, Manuel Saltz, Joel Salvatore, Steven ,244 Salvi, Sandra Samal, Aurobinda ,235 Samankan, Shabnam Samant, Sandeep Samaras, Dimitris Samaratunga, Hemamali...202, ,246 Samdani, Rashmi Samimi, Sara Samolczyk, Julia ,239 Samuel, Julian Samuelson, Megan ,143 Sanati, Souzan Sanchez-Cid, Lourdes Sanchez, Beatriz Sanchez, Diego F ,222 Sanchez, Douglas Sanchez, Eduardo Vilar Sanchez, Jessica Sanchez, Teresa Sandell, Rosalind Sanders, Devin K Sanders, M L Sanders, Mary Ann ,195,237 Sanders, MelindaE...22, 23,... 73,94,108 Sanders, Ronald D Sanders, Ronda ,247 Sandhu, Jasmin Sandison, Ann ,137 Sanfrancesco, Joseph ,133, Sangoi, Ankur Sanmartin, Elena Sansano, Irene Santacana, Maria Santagata, Sandro... 23,189,257 Santella, Regina M Santi, Raffaella Santiago, Teresa Santiago, Victor Santini, Donatella DS ,210 Santos-Zabala, Maria Laureana Santos, Gilda Sanz, Javier Saornil, Maria A ,190 Saqi, Anjali Sar, Aylin ,247 Saravanan, Arthy Sardiña, Luis A Sargent, Rachel Sarin, Kavita Sarmiento, Juan M ,175, ,254,255 Sarrias, Maria R Sarungbam, Judy ,176 Sasaki, Sho Sasaki, Tomoyo Sasano, Hironobu...43,187 Sassa, Naoto Sata, Naohiro ,

354 INDEX Satgunaseelan, Laveniya Sato, Shun Sato, Shuntaro Satoskar, Anjali A Satturwar, Swati Saulino, David ,243 Sauter, Jennifer L ,157 Savage, Erica Savage, Johanna Savant, Deepika ,244 Savio, Antonella Savona, Michael R Sawamura, Tatsuya Saxena, Romil...25,120,...121,184,190,229 Sayed, Shahin Sayeed, Sadia Sazonova, Olga , 155 Sbaraglia, Marta ,166,236 Sboner, Andrea ,212, ,235 Scandura, Glenda Scapa, Jason V ,190,200 Scardino, Peter Scattone, Anna Scavuzzo, Anna ,246 Scelo, Ghislaine ,212 Schaberg, Kurt ,230 Schaefer, Inga-Marie ,194 Schaefer, Rachel ,223 Schaeffer, DavidF , 142, ,255 Schaeffer, Edward M ,223 Schally, Andrew V Schandl, Cynthia A Schechter, Shula Scheitler, Kristen M Scher, Howard I ,123 Scherr, Douglas S Schiano, Thomas D ,183,230 Schieda, Nicola Schiffman, Marc H Schildhaus, Hans-Ulrich Schimmer, Aaron ,207 Schlumberger, Martin Schmechel, Stephen Schmid, Ralph A Schmidt, R A Schmidt, Robert L ,176,234 Schmitt, Alessandra...119, ,240 Schmitt, Fernando Schmolze, Daniel Schneider, Frank Schneider, Jowaly Schneider, Sallie S Schneider, Sarah Schniederjan, Matthew ,185 Schnitt, Stuart J... 27, 28,86, , 108 Schoedel, Karen E ,236 Schoenfield, Lynn Schofield, Kevin Schoolmeester, J Kenneth Schott, Anne F Schouweiler, Katie Schrage, Matthew Schrock, Alexa ,122,123, ,129,150,172,177,187,191, ,193,231 Schroedter, Ingo Schrum, Adam Schulte, Klaus-Martin Schulten, Hans-Juergen Schultz, Daniel Schultz, Nikolaus Schumacher, Jonathan ,253 Schuster, David M Schuuring, Ed Schwab, Richard Schwalbe, Michael Schwartz, Lauren E ,158,175 Schwartz, Mary R ,114, ,170 Schweizer, Michael Schwetye, Katherine E Schwock, Joerg Sciallis, Andrew ,178 Sciarrone, Salvatore Scognamiglio, Theresa...91,103,...137,156,171,257 Scolyer, RichardA...95, 100 Scott, John P Scott, Rona Scotti, Mauro Sebastiano, Christopher Seegmiller, Adam Seethala, Raja R...22, 23, 75,...137,138,150,164,204 Segal, Jeremy ,173 Segal, Joshua Segal, Neil Seheult, Jansen Sehn, Jennifer Seidman, Michael A...71, 114, , 257 Seipel, Amanda H Seisen, Thomas Seitz, Gerhard Seitz, Jan Sekar, Rishi R Sekhar, Aarti Sekhon, Harman S ,240 Selenica, Marina Selenica, Pier Selvaggi, Suzanne ,142 Selvaraju, Suresh B Sen, Chandra Sen, Seema Senapedis, William Senarathne, Wijendra SenGupta, Dhruba Sengupta, Sandip Senz, Anne Seow, Albert Sepulveda, AntoniaR...66, 198, Sepulveda, Jorge ,219 Serdy, Kate ,179,237 Serio, Gabriella Serra, Stefano...190,199,209,219 Serrano, Jonathan Sessa, Fausto ,171,192 Sesterhenn, Isabell ,147, ,245 Seth, Arun ,216,225 Sethi, Sanjeev ,136,253 Sethi, Shenon ,141,180 Setia, Namrata ,117,...122,143,173,174,198, ,240,254 Seto, Matthew Setoodeh, Sasan ,170 Settembre, Elizabeth Setty, Suman Sexton, Donal Sfanos, Karen S Sfreddo, Hannah J Shaar, Mohanad183, Shabana, Marwa E Shabihkhani, Maryam ,200 Shackelford, Rodney ,256 Shaddy, Sophia M Shafizadeh, Nafis ,183 Shah, Alpa B Shah, Anup Shah, Jatin Shah, Kabeer Shah, Mit D Shah, Rajah Shah, Rajal...67 Shah, Ronak H Shah, Sejal ,183 Shah, Varsha I Shahi, Maryam ,164,165 Shahin, Nisreen Abu Shahmarvand, Nahid Shahsafaei, Ali Shaib, Walid Shaikhibrahim, Zaki Shalin, Sara C...23 Shamanna, Rashmi Kanagal Shamash, Jonathan Shamir, Eliah Shan, Ling Shan, Mu Shanbhag, Namita Shandiz, Alaleh Esmaeili...122, ,154 Shang, Guoguo Shanmugam, Vignesh Shanmugham, Pramesh Shao, Haipeng ,208 Shao, Lina...122,208,214,253 Shapiro, Linda G Shareef, Mohamed M Sharma, Aarti Sharma, Anjana Sharma, Anurag ,235 Sharma, Gaurav...23,234 Sharma, Meenal ,230,244 Sharma, Mehar C Sharma, Rajni ,115,125,...139,168,175,176,247 Sharma, Rohit Sharma, Sachein ,154 Sharma, Shivani ,185, ,235 Sharma, Shree G... 22,23,257 Sharp, Linda Sharzehi, Setareh Shaver, Aaron C Shaw, Gene R Shaw, Kenna Shaw, Kristin Shaw, McKenzie Shaw, Patricia ,164,179 Shaw, Reid Sheedy, Frederick Sheehan, Christine E ,115,...116,123,127,131,133, ,224,251 Sheehan, Margaret Shehatou, Teriza Sheibani, Khalil Sheils, Orla ,213 Shelekhova, Ksenya V Shelton, Jeremy Shen, Hong ,229 Shen, Jess Shen, Li Shen, Ronglai ,223 Shen, Rulong Shen, Steven... 46,88,257 Shen, Tiansheng ,170,238 Shen, Wei Shen, Yulei Sheng, Dong Sheng, Shijie Sheng, Weiqi Shepherd, Neil Sheppard, Mary N ,170 Sheridan, Todd B Sherpa, Palzum Shervinrad, Mohammadreza Shestakova, Anna Shetty, Omshree Shetty, Prakash Shi, Chanjuan ,200,257 Shi, Jianhui ,229 Shi, Jiaqi ,190,255 Shi, Min Shi, Mingxia Shi, Qian Shi, Qiuying Shi, Wenjing Shia, Jinru ,120,211, ,243 Shibemba, Aaron L Shieh, Wun-Ju Shiekhmohammed, Mohammed Shields, Anthony Shih, Angela ,188,228 Shih, Ie-Ming Shih, Natalie Shillingford, Nick Shilo, Konstantin ,257 Shimizu, Akira Shimizu, David M Shimizu, Ken Shimizu, Michio Shin, Eugene T Shin, Junyoung Shin, Kseniya Shin, Sandra J...40, 108,...139,140,168,210,216 Shin, Su-Jin Shintaku, Itsushi P Shirai, Keisuke Shirsat, Hemlata Shiue, Yow-Ling Shkedy, Sara Shnitsar, Iryna Sholl, Andrew B Sholl, Lynette M... 55, 84, 101,...110,112,137,164,165,178, ,226,254 Shon, Wonwoo ,198 Shows, Jared T ,214 Shponka, Volodymyr Shrestha, Rupendra Shrikhande, Shailesh Shroff, Stuti G

355 INDEX Shu, Catherine Shui, Ruohong Shuja, Sania Shukri, Amal Shulman, Ira A Si, Qiusheng ,141,223 Siaghani, Parwiz ,228,252 Sibley, Richard ,230 Sibony, Mathilde ,202 Sibulesky, Lena230 Sica, Gabriel...117,150,175,220 Sidawy, Mary Siddiqi, Ahsan Siddiqi, Anwer Siddiqi, MA Siddique, Ayesha Siddiqui, Farzan Siddiqui, Javed ,122, ,176,191 Siddiqui, Momin T ,117,...122,128,129,133,139,158, ,195,204,217,218,236,240 Siddiqui, Uzma ,240 Sidiropoulos, Nikoletta Sidorenko, Tatyana ,199 Sidorov, Dmitry Sieber, Oliver Siegal, Gene P...25, 27, 57,...115,170,205,238 Sienko, Anna Sierra, Adriana Sigel, Carlie Sigel, Keith ,141 Signori, Riccardo Sikora, Andrew G Sillero, Maria Cobos Silva, Annacarolina Da ,254 Silva, Elvio Silva, Oscar ,153 Silva, Thais Silverman, Brittany Silverman, Jan F ,159,...205,209,212,218,238,246 Silvero, Arturo ,222 Sim, Jordan ,218 Simard, Serge ,132 Simi, Lisa Simon, Marina Simpson, Jean F...73, 115 Simpson, Roderick HW Simsir, Aylin ,181,239 Sinard, John H.22, 137, Honors Tab Singanamalli, Asha Singer, Bart Singh, Arbind ,231 Singh, Arjun Singh, Charanjeet Singh, Harsharan K...74, 182 Singh, Kamaljeet ,115, ,168 Singh, Kanchan Singh, Naveena ,178 Singh, Rajendra Singh, Rajesh R , 155, ,234 Singh, Varsha Singhi, Aatur D ,191,200 Sinha, Namita Sinicrope, Frank A Siqueira, Sheila Sircar, Kanishka , 203 Siref, Andrew Sirintrapun, Sahussapont Joseph , 123, 133,175,176, 181, , 218 Sirohi, Deepika ,222 Siroy, Alan E ,241 Sison, Cristina Siziopikou, Kalliopi P...63, 73, 94,...115,140,204,231 Skala, Stephanie ,175, ,191 Skalova, Alena Skelly, Joan Skenderi, Faruk ,243 Skipper, Daniel C Skrabek, Pamela Slade, Jamie ,164,239 Slingluff, Craig L Slivka, Adam ,191 Sloan, Emily A ,180 Slodkowska, Elzbieta ,216 Slomovitz, Brian Small, David Small, Eric Small, Thomas ,173 Smati-Grangeon, Sarra Smith, Amber L ,239 Smith, Joshua Smith, Kelly Smith, Lauren ,257 Smith, Paul J Taylor Smith, Stephen M Smith, Steven C... 26, 113,122,...124, 133,202,222, 257 Smith, Theresa Smola, Brian Smyrk, Thomas... 73,120,173,183 Sneige, Nour Snezhkina, Anastasiya ,211 Snir, Olivia L Sniukiene, Vilma Snover, Dale C ,190 Snow, Anthony ,157 Snuderl, Matija...131,181,196,236 Snyder, Vivian S Snyderman, Carl H Soares, Fernando ,222 Sobel, Mark E...55 Socec, Catherine I Soda, Masakazu Sohani, Aliyah ,253,257 Sojitra, Payal Solanki, Malvika Solanki, Shraddha Solcia, Enrico Soler, Teresa Soliman, Mahmoud L Soliman, Moaaz Solit, David...107,123,175,211 Solomides, Charlambos Solomon, David Solomon, Isaac ,208 Solomon, James ,247 Solorzano, Carmen C Somerset, Hilary ,150 Sominidi-Damodaran, Sindhuja Son, Jung Hoon Son, Seung-Myoung Sonawane, Shankar Sonawane, Snehal Sonett, Joshua Song, Buer Song, Hyung Geun Song, Jinming ,207,208 Song, Joo...192,228,251,252 Song, Sharon Song, Weihua Soni, Shardul Sonkar, Abhinav A Sonmez, Ceyda ,236, ,238 Sono, Reiri Sood, Gagan Soong, Richie ,201 Soong, Thing Rinda , 247, 249 Sorrells, Shelly Soslow, Robert ,111,...150,164,179,250 Soto, Luis R Soubra, Ayman Souers, Rhona J ,157,238 Soukiazian, Armen Soukiazian, Nyrie Soundar, Esther Soundararajan, Suganthi.125,254 Southey, Melissa Souza, Carolina A Sowamber, Ramlogan Sowder, Aleksandra Sozzi, Gabriella Spada, Neal Spagnolo, Dominic V Spatz, Alan Spaulding, Reed Specht, Charles S...99 Specht, Katja Spence, Jan ,228 Spence, John Sperga, Maris Spillane, Cathy ,213 Spilseth, Benjamin Sporn, Thomas A , 155 Spratt, Daniel E ,176 Sprenkle, Preston Springer, Simeon Spruill, Laura Sriganeshan, Vathany Srinivasan, Ramaprasad Srivastava, Amitabh...94,172,...174,201,221,254 Srivastava, Shiv K ,147, ,245 Srivastava, Supriya Srougi, Miguel Staats, Paul ,239,257 Stadler, Zsofia Staerkel, Gregg A Staley, Charles Stallworth, Christina Stambolic, Vuk Stanek, Jerzy Stanich, Peter Stanoyevitch, Alexander Starostik, Petr ,183 Starova, Blerta Stashek, Kristen M Stattin, Pär Steele, Cindy Steele, Jane C Steele, Rebecca M Stefano, Danielle De Stehlik, Jan Steinbauer, Bibiana Steiner, David Steiner, Petr ,203 Steinhoff, Margaret M ,162, Stelling, Adam Stelow, Edward B Stem, Kodie Stemmer-Rachamimov, Anat...67,...99,129 Stemmer, Melissa Stence, Aaron A ,236 Stepanov, Oleg Stephens, Philip ,114,115,...122,123,126,129,150,172,...177,187,191,192,193,231 Stephenson, Philippe Stevens, Todd Stevenson-Lerner, Heather...184, Stevenson, Margaret K Stewart, Colin J ,198,225 Stewart, Delisha Stewart, Douglas A Stewart, Jimmie ,218 Stewart, Jocelyn M Stewart, John Stewart, Rachel L Stiles, Brendon M Stinner, Jessica Stockley, Tracy Stoffel, Michelle Stoler, Mark H Stolnicu, Simona ,250 Stone, James R Stone, Jason...64 Stoopler, Mark Stram, Michelle ,141 Straten, Marta Van Straub, Melissa ,178,238 Streutker, Catherine ,199 Stricker, Phillip D Strickland, Kyle C ,172, ,226 Strickland, Stephen A Striker, Gary E Strosberg, Jonathan R Stuart, Josh Stuart, Lauren N ,157 Stueck, Ashley E Sturgis, Charles D ,119,...125,141,195,240 Sturm, Nathalie Su, Nan ,255,256 Su, Shirley Y Su, Ting-Yi Suarez, Adrian ,181 Suarez, Yvelisse Sudhanshi, Jain Sugai, Tamotsu Suh, Hyerim Suh, James ,114,115,...122,123,126,129,150,172,...177,187,191,192,193,231 Sui, Dawen Sui, Long Sukeda, Aoi Sukhanova, Madina Sukhu, Balram

356 INDEX Sukov, William R ,124,...165,188,220,241 Sullivan, Megan E Sulman, Erik P Sumathi, VP Sun, Belinda Sun, Hongxia Sun, Katherine Sun, Lulu Sun, Tong ,217 Sun, Wei Sun, Weijing Sun, Xiangjie Sun, Yi ,192 Sun, Yue ,223 Sundar, Manonmani ,210 Sunday, Mary E Sundin, Andrew Sundling, Kaitlin Sundram, Uma...65 Sung, C James , 115,116, ,224,250 Sung, Diana Sung, Yun-Shao ,166,236 Suñol, Mariona ,252 Suo, Liye Sur, Monalisa...72 Suriawinata, Arief Surti, Urvashi ,205,207 Susma, Alexandru Suster, David Suster, Saul... 76,138,156,193, ,202,203 Sutton, Ann Suva, Mario Suzuki, Ayako Svensson, Maria Swamy, Vinushree ,163,228 Swanson, Benjamin J Swanson, David ,195, ,236,256 Swanson, Paul E... 27, 230, 243 Swarrow, Rachel ,210 Swartwood, Steven Swee, Melissa Sweet, Joan ,246 Sweet, Kevin Swerdlow, Steven H ,207, ,252, Honors Tab Swisher, Elizabeth Syed, Jamil Syed, Sahr Sykes, Lorraine Symmans, W. Fraser...99 Symmons, Martyn F Szabo, Gyula Szafran, Adam T Szankasi, Philippe ,253 Szigeti, Reka T Tabatabai, Z Laura ,238 Tabosa, Gabriel VBS ,203,246 Tacha, David Tada, Toyohiro ,185 Tade, Funmilayo Taege, Alan Tafe, LauraJ... 77, 101,110, ,191,225 Taffurelli, Giovanni Tagawa, Scott T Taggart, Melissa Taheri, Diana ,175,176 Taieb, Julien Tajiri, Takuma Takahashi-Fujigasaki, Junko Takahashi, Hiroyuki Takahashi, Yayoi Takano, Masato Talaat, Iman Talamayan, Michael John C Talat, Nadia Talevich, Eric Talha, Rashid Talhouk, Aline ,248 Taliano, Ross Tallini, Giovanni ,171 Talman, Maj-Lis M Talmon, Geoffrey Talwar, Aditya Tam, Simone Tam, Wayne... 27,251,252 Tamboli, Pheroze...46,92, ,203 Tambouret, Rosemary H Tamimi, Rulla Tamm, Eric P Tamura, Daisuke Tan, Benjamin Yongcheng Tan, Chih-Fen Tan, Cong Tan, David SP Tan, Dongfeng ,229,244 Tan, Lee K Tan, Puay Hoon ,169, ,216 Tanaka, Kathryn E Tanaka, Reiko Tanas, Munir R ,235,236 Tang, Guilin ,192,...207,226,227,228 Tang, Jean Tang, Laura Tang, Ping Tang, Shangguo Tang, Shaoxian Tang, Yen Zhi Tang, Zhenya ,226 Tanguay, Jeffery J Taniguchi, Hiroyuki Tao, Xiang Taouli, Bachir Taplin, Mary-Ellen ,222,223 Tarabishy, Yaman ,121,...163,173,200,219,244 Tarrel, Robert F Tas, Patrick Tashakori, Mehrnoosh Tashkandi, Hammad Tateishi, Yoko Tatevian, Nina Tateyama, Hisashi Taub, Robert Taube, Janis M...83, 87,...129,139,156,235 Tavassoli, Fattaneh ,169,236 Tawfik, Ossama ,141,168 Taylor, Barry S ,175 Taylor, Clive R ,181 Taylor, Jennifer Taylor, William R Tayyari, Farnoosh Tazelaar, Henry D... 24, 71, 104, ,188 Teer, Jamie Tefferi, Ayalew Teh, Bin Tean ,169 Teh, Ming Telatar, Milhan Temprana-Salvador, Jordi Teng, Jiamin ,159 Teng, Kun-Yu Teng, Lianghong Teo, Min Yuen , 175 Teo, Soo-Twang Terada, Yukihiro ,225 Terasaki, Mika Terasaki, Yasuhiro Terinte, Cristina ,250 Terra, Simone...131,188,230, 246 Terracciano, Luigi Terrones, Alexis B Teruya-Feldstein, Julie Terzic, Tatjana...164,180,240,249 Teshima, Christopher Tesic, Vera Tessier-Cloutier, Basile ,220, ,251,255 Tetzlaff, Michael T ,125,...186,191,228,241 Tewari, Ash Tewari, Prerna Tezel, Gaye Y Güler Thambudorai, Robin Thapa, Prabin Theise, Neil ,173 Theisen, Brian Theparee, Talent Thiberville, Luc Thiele, Juergen Thiene, Gaetano Thike, Aye Aye ,169 Thivolet-Bejui, Françoise Thomas, Dafydd G , 197 Thomas, George Thomas, Geraldine Thomas, Kristen M Thomas, Lynita Thomas, Rebecca Thomas, Sarah C ,199 Thomas, Sumi Thomason, Jon ,235 Thompson, Elizabeth ,139 Thompson, Lester ,138, ,193 Thompson, R H Thompson, William ,246 Thomson, Brian Thomson, Timothy Thorat, Swati Thorn, Lindsay Thorner, Aaron Thorson, John A ,208 Thrall, Michael J Thung, Irene ,209 Thung, Swan N Thway, Khin...69,257 Tian, Tian Tian, Wei Tian, Xuejun Tickoo, Satish K ,123,...133,175,176,201 Tietz, Birgit Tihan, Tarik... 24,29,41,190 Tilan, Jason Timpe, Leslie Ting, David T Tinker, Anna Tischkowitz, Marc Tiska, Grace Tissier, Frederique Tiwari, Pallavi Tiwari, Sarita Tiwari, Vandana Tixier, Lucie ,196 Tjendra, Youley Tjionas, George A Todd, Nevins W Toffolatti, Luisa Togashi, Miku Tokudome, Nahomi Tomaszewicz, Keith Tomaszewski, John E Tominaga, Susumu Tomlin, Bryan Tomlins, Scott A ,122,...133,146,176,197,223 Tondon, Rashmi Toner, Mary Tong, Guo-Xia Tong, Tommy Tonooka, Akiko Topaloglu, Umit Toquet, Claire Torabi, Alireza ,235 Torbenson, Michael S...50, 56, 70,...101, 129,157,166,167,183 Torii, Sho Torkko, Kathleen Tornos, Carmen Toro, Gonzalo de...71 Torous, Vanda ,109,217 Torre, Matthew Torres-Cabala, Carlos A ,191,208,241 Torres-Mora, Jorge ,220,247 Torres, Alba FC ,146 Torres, Joana Torres, María M , 251 Torres, Mylin A Tos, Angelo P Dei ,166, ,236 Toslak, Iclal Erdem Tosoian, Jeff Tosoni, Antonella Tosun, Akif B Touijer, Karim A Toussaint, Andy Toyokuni, Shinya Tozbikian, Gary Tracht, Jessica Trahan, Sylvain ,132 Train, Laura J ,189 Tran, Henry Tran, Hung Tran, Lily ,180 Tran, Thu Tran, Tram Travis, William... 43,64,111,...112,154,156,188 Traylor, James G

357 INDEX Treaba, Diana Tregnago, Aline C ,175, ,247 Trepeta, Richard Treseler, Patrick Tretiakova, Maria ,147, ,201,257 Trevathan, Sean Trevino, Karen ,123 Trifilo, Katelyn E Trindade, Christopher J ,205 Tripathy, Debu Tripp, Sheryl Trivedi, Anshu Trivella, Juan P Trock, Bruce J Troxell, Megan ,216 Trpkov, Kiril... 46,97,123, ,202,247 Trudeau, Maureen Trudel, Dominique True, Lawrence ,111, ,201,245 Truong, Camtu D , 243 Truong, Duy Truskinovsky, Alexander M Tsai, Harrison Tsai, Jen-Wei ,194,236 Tsai, Jia-Huei Tsang, Julia YS Tsao, Christin H Tse, Gary M Tse, Julie Y Tse, Ka Yu Tseng, Hsian-Rong Tseng, Wiliam W Tsesmetzis, Nikolaos Tsokos, Maria Tsongalis, Gregory J ,191, ,256 Tsuchikawa, Takahiro Tsujimura, Tohru Tsung, Allan Tsuzuki, Toyonori Tu, Xiaoyu Tuchiya, Tomoshi Tull, Jamie Tuluc, Madalina Tumas, Jordyn B Turashvili, Gulisa ,237 Turbat-Herrera, Elba A ,240 Turcotte, Stéphane Turk, Andrew T Turner, Bradley M Tutaeva, Victoria Tuttle, Kimberly ,139 Tuttle, R Michael ,171 Twaddell, William Twardowski, Przemyslaw Tyekucheva, Svitlana U Uamg, Huaitao Ubago, Julianne M Uccella, Silvia Uchida, Katsunori Uchiyama, Tomoko Udager, Aaron M , 119, 122,175, 176,223 Udo, Emiko Uehara, Takeshi ,199 Ueki, Nozomi Ueno, Takashi Uesugi, Noriyuki Ugalde, Paula Ulamec, Monika Ulbright, Thomas M ,123, ,188,222 Ullman, David Umar, Beena Umeda, Shigeaki Umetsu, Sarah E ,166,212 Umphress, Brandon ,249 Underwood, Dawn Unger, Pamela Unitt, Christine Uniya, Upasana Untanu, Ramona Uram-Tuculescu, Cora ,205, Urista, Gerardo Aristi Urken, Mark L Uruga, Hironori Ushiku, Tetsuo Ussakli, Cigdem Uto, Kenta Uzel, Gulbu V Vachharajani, Neeta ,230 Vadlamudi, Kumari Vafaii, Pardis Vaghasia, Ajay Vaghefi, Amineh Vaickus, Louis J Vail, Paris J ,220 Vaiyapuri, Sumathi ,236 Vakar-Lopez, Funda Vakiani, Efsevia ,211, ,243, 257 Valasek, Mark A ,208, ,244 Valbuena, Jose R Valderrabano, Pablo Valencia-Cedillo, Raquel Valent, Alexander Valentino, Alessandro Valera, Alexandra Valesini, Guido Valle, Javier A Baena Del...111,246 Valle, Juan Vallejo-Benítez, Ana Vallone, Joseph Valluru, Neelima ,209,213 Valori, Laura VanBeek, Christine VandenBussche, Christopher J , 101, 116, 117, 130, 217 VanderLaan, Paul ,217 Vanecek, Tomas Vanel, Daniel ,236 Vang, Russell...115,125,164,257 Vankalakunti, Mahesha Vanoli, Alessandro ,192 Varadan, Vinay Varadhachary, Gauri Varambally, Sooryanarayana Vardaki, Ioulia Varesano, Serena Varga, Zsuzsanna ,168 Vargas, Cindy Vargas, Sara Varghese, Sharlin Varma, Kavita R ,179 Varma, Kavita Varma, Sonal ,196,216 Varma, Sushama Varma, Vishal K Varney, Ruan C Varshney, Neha Vasa, Puneeta S Vasef, Mohammad Vasiliadis, Theodore Vasiljevic, Alexandre Vasmatzis, George ,124, ,246 Vassallo, Robert Vavinskaya, Vera ,209 Vaz, Fátima Vazquez, Ivonne Vega, Francisco ,227,251 Vega, Jose E Velazquez...129, ,190 Vega, Sandra Veillon, Diana M Veinot, John...26 Veits, Lothar Velcheti, Vamsidhar , 240 Velez, Moises J Velloso, Elvira Veloza, Luis Venick, Robert S Venkataraman, Girish ,198 Vennapusa, Bharathi Venta, Luz A Veremis, Brandon Vergilio, Jo-Anne ,114,...115,122,123,126,129,150, ,177,187,191,192,193,231 Verhoest, Gregory ,247 Verma, Amit Verma, Anuj Verstak, Brett Viaene, Angela Viala, Sandrine Vidal, August Vidal, Claudia I...65 Vidal, Igor Vielh, Philippe Vierkoetter, Koah Vierling, John Vieth, Michael ,244 Vignali, Marissa Vij, Kiran R Vijver, Koen Van de Vikneswari, Rajasegaran Vila, Jordi Vilaseca, Isabel Villa, Vanessa Grace M De Villada, Gabriel Villalobos, Pamela ,255 Villanueva, Alberto Villaseca, MiguelAngel ,191, Vinayak, Shaveta Vincentelli, Cristina Vinco, Michelle L Virk, Sohaib Virmani, Renu Visscher, Daniel W ,195 Viswanath, Satish Viswanatha, David S ,207 Vitkovski, Taisia ,169 Vivallo, Carolina Vivero, Marina ,112, ,240,257 Vizcaino, Maria Adelita Vladoiu, Maria-Claudia Vlassara, Helen Vnencak-Jones, Cindy L Vogel, Ashley N Vogel, Hannes...41,178 Vogel, Rachel I Vogel, Victor G Vogelstein, Bert Vohra, Poonam Volchenko, Nadezhda Volmar, Keith E... 99, 156,157 Volpato, Anna G Voltaggio, Lysandra ,121,...172,173,200,219,244 Volyanskyy, Konstantin ,204 Volz, Marcus R vonrentzell, Jeanne E Vora, Moiz ,256 Vora, Tushar Vos, Jeffrey...68 Vose, Julie M Vosoughi, Aram Voss, Jesse S Voss, Martin H Vrana, Julie A Vrancken, Michael Van ,221 Vranic, Semir ,194,243 Vuong, Huy G Vyas, Monika ,199 Vytlacil, Christopher ,218 W Wachsmann, Megan Wade, Scott L Wadile, Amol Wagner, Siegfried Wajapeyee, Narendra Wake, Laura Wakely, Paul E...22, 24, 88, ,218,241 Wala, Samantha Walavalkar, Vighnesh ,237 Wald, Abigail Walia, Saloni Walker, Kimberly ,119, ,249 Walker, Neal Walkovich, Kelly Wallace, Dean Walsh, Edward G Walsh, Joanna C Walsh, Michael Walter, Matthew ,228 Walter, Vonn Walts, Ann E Waluszko, Aneta ,199,204 Wang-Miller, Su Wang, Alun R Wang, Anna Y Wang, Ariel SY Wang, Beverly Y

358 INDEX Wang, Chen Wang, Dehua ,214 Wang, Dennis Wang, Endi ,214,227 Wang, Guiqing ,209 Wang, Guisong Wang, Hai ,195 Wang, Hangjun Wang, Hanlin L...56, 183,...184,190,221,229 Wang, Hao-Wei Wang, He...112,116,117,126 Wang, Helen H Wang, Helen H Wang, Hua Wang, Huamin ,210 Wang, Huan-You Wang, Jianfu Wang, Jindong Wang, Jinhui ,251 Wang, Kai...115,126,150,174 Wang, Lai Mun Wang, Larry Wang, Lei Wang, Li Juan , ,230, 248 Wang, Li-Chong Wang, Li-Ping Wang, Li Wang, Lin Wang, Linlin ,183 Wang, Lu ,217,236 Wang, Lynn Y Wang, Michael Wang, Mingsheng Wang, Minhua Wang, Minjing Wang, Peng Wang, Sa ,153,162,...163,192,206,207,227,228 Wang, Shu-Juan Wang, Tian-Li Wang, Ting Ting Wang, Wei-Lien ,166,191,...193,194,195,197,236, ,248, 257 Wang, Wei...128,163,226,227 Wang, Weige Wang, Weixin Wang, Xiangxue Wang, Xiao-Ming M , 255,256 Wang, Xiaofei ,244 Wang, Xiaoyan Wang, Xuan J Wang, Yan Wang, Yanhua ,186,207 Wang, Yao Wang, Yaohong Wang, Yihong ,120,...162,195,224,257 Wang, Ying ,146,223 Wang, Yiying Wang, Yu-Chen Wang, Yuxuan Wang, Zengfeng , 241 Wang, Zhen Wang, Zhenglong Wani, Khalida...166,194,195,236 Ward, Heather Ward, Kevin C Ward, Mark Ward, Nicholas D Ward, Stephen C ,183,254 Warf, M Bryan Wargo, Jennifer A Warlick, Christopher Warmke, Laura Warnke, Roger Warren, Christine B Warren, Daniel Warrick, Joshua I ,151,171 Wartenberg, Martin Wasag, Bartosz Wasco, Matthew J...25, 203 Wasfy, Rania E Washburn, Erik R ,217 Washington, Kay Wasserman, Allison M Watanabe, Shun-ichi Waters, Kevin ,121, ,173,189,200,219,229,244 Watkin, William ,132 Watkins, Jaclyn C Waxman, Irving ,240 Weaver, Donald L ,158 Webb, Milad Weber, Christopher ,173,257 Wei, Bo Wei, Christina ,222 Wei, Dongguang Wei, Eric X Wei, Guijian Wei, Jian-Jun Wei, John Wei, Shi...115,146,170,194,238 Weichert, Wilko Weiel, Julianna J Weigelt, Britta ,150,...151,168,169,211 Weihua, Huang Weinberg, Olga K ,206,207 Weinreb, Ilan... 26,75,150,151 Weinreb, Jeffrey Weins, Astrid Weir, Michele M ,143 Weisenburger, Dennis D...192, ,251,252 Weiser, Martin Weisman, Paul Weiss, Lawrence Weiss, Ronald L Weiss, Vivian Weissferdt, Annikka Weizer, Alon Z ,176 Weksler, Benny Welch, Marisa Welder, Daniel Welsh, Cynthia Wemmer, Megan Wen, Hannah Y...73, 136, ,236,237 Wen, Kwun Wah Wen, Shuai Wendy, Wong Wenger, Doris Wenig, Bruce M , 104, 138 Wenstrup, Richard Wertheim, Gerald Wessel, Irene West, Robert , 173 Westaby, Joseph ,170 Westerhoff, Maria... 23,167,190,257 Westra, William H ,112,...126,136,137,150,240 Wey, Elizabeth Weynand, Birgit Wheelan, Sarah J Wheeler, Darren T...23 White, Bartholomew White, Charles L White, Christine White, Kristie L... 24, 113,137 White, Marissa Whitehall, Vicki Whitington, Thomas Whitman, Jeffrey Whitney-Miller, Christa L Whitney, Jon ,211 Wi, Youngchan Wians, Frank H ,235 Wieck, Lucas Wiesner, Georgia L Wietlisbach, Larissa Wiggins, Charles Wiklund, Peter Wilcox, Ryan Wild, Peter Wiles, Walter G Wiley, Clayton Wiley, Elizabeth ,237 Wilkerson, Myra L Wilkes, David C Wilkinson, David S...27 Wilky, Breelyn William, Christopher Williams, David Williams, Dawn Williams, Erik Williams, Grant Williams, JoAnna Williams, Marcus D Williams, Michelle D...58, 75, ,239 Williams, Nicole C , 139,171 Williams, Phillip Williams, Roy Williamson, Alex K Williamson, Sean R...23, 25, 67,...133,177,202,203,224, 257 Willis, Brian C ,125,180 Willis, Eric Wilson, Christine Wilson, Julie M Win, Aung K Winer, Daniel Winer, Joshua H Winnepenninckx, Véronique Winship, Ingrid ,174 Winters, Gayle...71 Winton, Elliott Wistuba, Ignacio I ,200, ,248,255 Wiszowaty, Alicja ,237 Witkiewicz, Agnieszka K ,220 Witt, Benjamin L ,165,238 Witte, Owen Wobker, Sara E ,177,203 Woda, Bruce A Wojcik, Eva M , 109, ,177,217 Wojcik, John...72 Wolak, Emily Wolfe, Jenna Wolff, Daynna J ,216 Wolff, Robert Wollison, Bruce Wolpin, Brian Wolsky, Rebecca J Wong, Adele ,158,225 Wong, Andrew..195,197,236,256 Wong, Jerry T Wong, Kristine S Wong, Mary ,181 Wong, Meng Kang Wong, Oscar GW Wong, Richard Wong, Serena ,178,236 Wong, Siew-cheng Wong, Waihay J Wong, Willard Wood, Brent L Wood, Christopher G Wood, Laura D... 23, 257, 121,166 Wood, Simon Wood, Stephanie Woods, Jennifer N Woolf, Nicholas Wooten, Melanie Wozniak, Laura J ,229 Wrana, Jeffrey L Wright, James R...62 Wu, Angela...107,129,201,223 Wu, Ashley Wu, Chao Wu, Elizabeth Yiru ,225 Wu, Erxi Wu, H Wu, Howard...142,143,155,218 Wu, Huiqing Wu, Natalie Wu, Peter Wu, Richard Wu, Roseann I...25 Wu, Sharon Wu, T.C...48 Wu, Tao Wu, Tongtong ,245 Wu, Tsung-Teh ,129, ,183,220 Wu, Xian-rui Wu, Xingyong ,256 Wu, Xinyu ,245 Wu, Xiwei ,251 Wu, Yadi Wu, Yiru Wu, Yun ,159,212 Wurst, Michelle N Wyrzykowski, Mary X Xess, Immaculata Xia, Daniel Xia, Rong Xia, Tian Xian, Rena R Xian, Zhaoying Xiao, Guang Q ,222 Xiao, Hong Xiao, Shu-Yuan ,121,...143,167,173,198,220 Xiao, Xiuli Xiao, Yaoxing

359 INDEX Xie, Catherine Xie, Hao Xie, Ming Xie, Steve Xin, Wei ,244,257 Xing, Deyin ,180,248 Xing, Dongmei ,244 Xing, Juan Xiong, Jinjun Xiong, Wei Xiong, Yin...157,193,210,242 Xu, Amanda Shuo Xu, Bin...138,150,171,238 Xu, Bo ,246 Xu, Haiying ,235 Xu, Haodong Xu, Huihong ,239 Xu, Jia ,182 Xu, Jianmin Xu, Jie ,228 Xu, Mina L Xu, Mina ,257 Xu, Ruliang Xu, Wei Xu, Xiaoli Xu, Ya ,170 Xu, Yan Xu, Yayun Xu, Zhaolin Xue, Yue ,174,191, ,220,254 Y Yab, Tracy C Yachnis, Anthony... 22, 27,72, 89 Yacoub, Joseph ,245 Yacoub, Mokrane ,247 Yagi, Yukako ,188 Yakirevich, Evgeny ,248 Yamada, Shozo Yamada, Yuichi Yamaguchi, Yuka Yamamoto, Hidetaka Yamanaka, Kazuki Yamasaki, Naoya Yamashita, Kyoko Yan, Jie Yan, Li ,139 Yan, Shaofeng Yan, Ying Yan, Zhen Yang, Bin Yang, Chen...120,125,180,254 Yang, Cheng-Han Yang, Chi-Shun Yang, Chuanhe Yang, David ,127 Yang, Dongfang Yang, Fei ,216 Yang, Fusheng Yang, George Yang, Guang-Yu ,173,211, ,242 Yang, Haichun Yang, Hong Yang, Huaitao Yang, Hui-Min ,199 Yang, Jing Yang, Kaixuan Yang, Michael C Yang, Michelle X Yang, Minnan Yang, Ping Yang, Qi ,245 Yang, Soo-Ryum Yang, Tong...122,133,185,226 Yang, Wei Yang, Wentao ,215 Yang, Ximing J ,203 Yang, Yang Yang, Zhaohai ,243 Yang, Zhongbo Yantiss, Rhonda K... 22, 24, 47, 73,... 92, 103, 106, 130,163,191,244 Yao, Keluo ,180,181 Yao, Song ,139 Yao, Takashi Yared, Marwan A...24, 40 Yasir, Saba ,183 Yassan, Lindsay ,117,173 Yassen, Noha N Yates, Jennifer Yazdani, Maryam Yazigi, Nada Yaziji, Hadi ,216 Ye, Fei...118,184,199,204,249 Ye, Huihui ,223 Yearsley, Martha Yegnasubramanian, Srinivasan Yeh, Chen Yeh, Iwei Yeh, Matthew M...105, 129,...183,229,230, 243 Yemelyanova, Anna ,255 Yen, Ten-Yang Yeoh, Khay Guan Yeong, Joe ,211,216 Yeung, Cecilia CS...66 Yi, Chun-Hui Yi, Eunhee S ,132,154, ,230 Yilmaz, Asli...123,176,202,247 Yilmaz, Helene Yin, Cameron...153,207,227,228 Yin, Changhong ,128, ,214 Yin, Minzhi Yin, Yu Yin, Zichang ,229 Yip, Linwah Yip, Stephen...81 Yo, Timothy Tay Kwang Yoder, Sean Yoest, Jennifer Yokomise, Hiroyasu Yong, William Yoon, Esther C ,179, ,185,229 Yoon, Ju-Yoon Yoon, Sun Och Yoon, Yoo-Seok Yorozu, Takashi Yoshida, Akihiko ,193 Yoshida, Makiko Yoshida, Megumi Yoshimoto, Toyoki Yoshimura, Masayo Yoshiura, Koh-ichiro Yoshizawa, Akihiko ,187 Yoshizawa, Saeko Yotsukura, Masaya You, Jia You, Xiaoming ,219 Younes, Mamoun ,243 Younes, Pamela S Young, Ken H Young, Neal S Youngren, Jack Youngson, Bruce Younke, Brianne Yousaf, Hira ,164 Yousef, George M ,202,247 Yousefi, Kasra ,223 Yousefi, Safoora...90 Yousem, Samuel A ,181 Yozu, Masato Yu, Baohua Yu, Bing Yu, Eunsil Yu, Jiangzhou Yu, Jing Yu, Jun Yu, Lianbo Yu, Wengdong Yu, Zhongxin Yuan, Chen Yuan, Ji Yuan, Liping Yuan, Songyang Yuan, Wei Yubero-Serrano, Elena M Yue, Changjun Yue, Ming Yue, Yong Yuh, Bertram Yung, Evan Yusuf, Yasmin Z Zaatari, Ghazi...33 Zaccarini, Daniel Zadeh, Sara ,180 Zafar, Nadeem Zafar, Rabia Zaidan, Bruna C ,203,246 Zaidi, Tanweer M Zain, Jasmine Zamagni, Claudio Zamboni, Giuseppe Zamecnik, Michal Zanatta, Lucia Zander, Dani S Zanetti, Maurizio Zapata-Tarres, Marta Zarbo, Richard Zarei, Shabnam Zaretsky, Andrew Zargham, Ramin Zarrin-Khameh, Neda Zarzour, Jessica Zavodszky, Maria Zeck, Jay Zedek, Daniel C...27 Zeh, Herbert J ,191 Zehir, Ahmet ,192,193 Zehnder, James ,206 Zehrouni, Nourredine Zeinah, Ghaith Abu Zeng, Jennifer ,196,225 Zeng, Xu ,167 Zeng, Zhengyu Zeppernick, Felix Zerbini, Maria Claudia Zhai, Haiyan Zhai, Jing Zhai, Qihui Jim...99,101 Zhan, Tingting Zhan, Yougen Zhang, Amy Hong Zhang, Amy J Zhang, Chao ,169,... 95,236,237 Zhang, Da ,208 Zhang, David Y...118,184,...199,204,211, 249 Zhang, Dongwei Zhang, Gloria Zhang, Hailing ,208 Zhang, Hongying Zhang, Hui...118,129,204,213 Zhang, Japing ,229 Zhang, Jiexin Zhang, Jinghui Zhang, Jiwang Zhang, Jun Zhang, Lei ,181, ,236,243 Zhang, Ling ,153,207 Zhang, Lingxin ,125, ,180 Zhang, Linsheng Zhang, Lizhi ,192,220 Zhang, Lun Zhang, Miao Zhang, Mingjuan L ,217 Zhang, Pan ,212 Zhang, Paul Zhang, Ping L ,182,229 Zhang, Pingchuan Zhang, Qing Zhang, Ranran ,172,242 Zhang, Shanxiang , 228 Zhang, Shaobo Zhang, Sharon S ,229 Zhang, Shengle Zhang, Tong Zhang, Tuo Zhang, Wei ,199 Zhang, Wenjing Zhang, Xiaofei...109,120, ,198 Zhang, Xiaohui ,207,208 Zhang, Xiaotun ,242 Zhang, Xuchen..121,199,229,245 Zhang, Xuefeng.120,183,203,257 Zhang, Yang ,156 Zhang, Yanhong Zhang, Yaxia...109,118,218,240 Zhang, Yonghong Zhang, Yonghua Zhang, Zhang Zhang, Zhenwei ,223 Zhang, Zhiqing Zhang, Ziying Zhao, Chengquan ,140,...141,142,249,250 Zhao, Cynthia Zhao, Fang Zhao, Huaqing

360 INDEX Zhao, Lei ,213 Zhao, Lili Zhao, Ming Zhao, Qing Zhao, Rachel Zhao, Shengnan Zhao, Shuchun Zhao, Songqing Zhao, Tianhao Zhao, Xiaofeng Zhao, Xiaohui Zhao, Xin Zhao, Yani Zhao, Yongxin Zhao, Zhizhuang Zhen, Chao J Zheng, BaoWen , 142,250 Zheng, Gang ,162 Zheng, Guangjuan Zheng, Lan ,226 Zheng, Qizhi ,146,246 Zheng, Shuling ,254 Zheng, Wenxin ,224 Zheng, Xirun Zhestkov, Mikhail Zhevelyuk, Ekaterina Zhong, Minghao...124,176,...179,185,201,203,204,209,...210,211,214,229,256 Zhou, Amy G Zhou, Fang ,239 Zhou, Haijun ,239 Zhou, Jiehao ,206,228 Zhou, Jing Zhou, Ming... 49,97,103,...123,146,147,223 Zhou, Shengmei ,214 Zhou, Shuang Zhou, Wenhua Zhou, Xianrong Zhou, Xiaoyan ,212,229 Zhou, Xinchun ,252 Zhou, Yaolin...23 Zhou, Yi Zhou, Yu Zhou, Zhongren ,244,245 Zhu, Daniel Zhu, Feng Zhu, Hongfa ,121,130,...190,198,200,210,219,245 Zhu, Menglei Zhu, Qingfeng Zhu, Xiaoqin (Cynthia) Zhu, Yazhen Zhu, Yifei Zhuge, Jian ,179,185, ,211,214 Zibadi, Sherma Ziffle, Jessica Van Zilberg, Catherine Ziober, Amy ,249 Zirpoli, Gary R Zlobec, Inti ,175,210 Zlotta, Alexandre R Znoyko, Iya Zoino, Roberto Zomorrodian, Sina ,211 Zoroquiain, Pablo... 88,130,190 Zou, Youran Zreik, Riyam ,157,207, ,249 Zsengeller, Zsuzsanna K Zu, Youli...55 Zukerberg, Lawrence Zuo, Chunlai ,131,133 Zuo, Tao ,140 Zuo, Zhuang...162,206,208,227 Zuppan, Craig Zuraski, Connor Zureikat, Amer H Zutter, Mary M Zuzga, David Zynger, Debra L ,147, ,236,

361 JULY COURSE FACULTY Adam Bagg, M.D. Co-Course Director Rhonda Yantiss, M.D. Co-Course Director Steven D. Billings, M.D Diagnostic Pathology Update Pragmatic Approaches to Daily Practice Prince George Hotel Halifax, Nova Scotia, Canada USCAP s Diagnostic Pathology Update course is uniquely designed to take your practice to the next level and challenge your imagination. While content is designed to close practice gaps and reinforce skills, the setting encourages a family opportunity to learn in a magnificent environment with time to explore the harbor, the town and the culture of Halifax. BodyWorks for Kids, a new element to familiarize your children with what you do, is an exciting way for your children to develop their understanding of the normal human body while you investigate its aberrations. The superb faculty polishes the USCAP gold standard with its informative wisdom and expertise. In a world of competitive learning opportunities, USCAP has launched a shooting star. Follow the light to Canada! Daniel J. Brat, M.D., Ph.D. Laura C. Collins, M.D. Jennifer Hunt, M.D. REGISTER NOW! David B. Kaminsky, M.D., FIAC Marisa R. Nucci, M.D. Victor E. Reuter, M.D.

362 TH ANNUAL MEETING GEARED TO LEARN MARCH Vancouver, BC, Canada TH ANNUAL MEETING March National Harbor, MD TH ANNUAL MEETING February 29 - March 6 Los Angeles, CA