Italian Society of Pharmacology Workgroup on Neurodegenerative Diseases
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1 Scientific program Registration Opening SESSION I Keynote Lecture introduced by Agata Copani (Catania) Eleonora Aronica (Amsterdam, NL) Neuropathology: a bridge between clinical and basic neuroscience Chairman: Mariagrazia Grilli (Novara) Giovanni Nardo (Milano) Induction of immunoproteasome and major histocompatibility complex I (MHCI) in motor neurons of a familial amyotrophic lateral sclerosis (ALS) mouse model Caterina Scuderi (Roma) Neuron-astrocyte interplay in neurodegenerative disorders: evidence and implications Vanessa Porrini (Brescia) Late-onset Parkinsonism in NF-kB/c-Rel-deficient mice: insights into novel drugable targets Coffee Break Scientific committee Maria Angela Sortino Agata Copani Monica Di Luca Fabrizio Gardoni monotemct@gmail.com Organizing committee Mariangela Chisari Maria Laura Giuffrida Sara Merlo
2 SESSION II Keynote Lecture introduced by Fabrizio Gardoni (Milano) Anna Karpova (Magdeburg, DE) Encoding and transducing NMDAR signals to the nucleus: communication over distance via Jacob Chairman: Marina Pizzi (Brescia) Francesca Guzzetti (Milano) Encoding synaptic GluN2A-containing NMDA receptor activation: the role of Ring Finger Protein Virginia Ronco (Novara) Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS Marco Milanese (Genova) Investigating the role of group I metabotropic glutamate receptors in amyotrophic lateral sclerosis Lunch and posters
3 SESSION III Technical corner Alessandro Cometta (Carl Zeiss Italia) A close up view on super-resolution Chairman: Anna Pittaluga (Genova) Irene Paterniti (Messina) The association of palmitoyl ethanolamide and luteolin decreases neuroinflammation and stimulates autophagy in an in vitro and in vivo model of Parkinson s disease Roberta Felici (Firenze) Effects of PARP inhibition in a mouse model of Mitochondrial Encephalopathy Marco Feligioni (Roma) Age-related changes of protein SUMOylation balance in the AbPP Tg2576 mouse model of Alzheimer's disease Carla Busceti (Pozzilli) Characterization of the glycoprotein dickkopf-3 in cerebral blood vessels of spontaneously hypertensive rats Conclusions
4 POSTER PRESENTATIONS Aricò Giuseppina (Catania) Involvement of sigma 2 receptor on motor disorder Bortolotto Valeria (Novara) Every cloud has a silver lining: Aβ(1-42) oligomers and HMGB-1 can promote adult hippocampal neurogenesis via RAGE/NF-κB axis activation Chisari Mariangela (Catania) Discerning the role of G protein g subunits in astrocyte function Cordaro Marika (Messina) Neuroprotection by association of palmitoylethanolamide with luteolin in experimental alzheimer s disease models: the control of neuroinflammation Costa Giulia (Cagliari) MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment, neurodegeneration and neuroinflammation in motor, limbic and cortical areas Crupi Rosalia (Messina) Liver x receptors activation, through to binding, decreases neuroinflammation in parkinson s disease D Antoni Simona (Catania) Endothelin-1 induced degeneration of Motor Neurons: a new potential pharmacological target for Amyotrophic Lateral Sclerosis Deidda Irene (Palermo) Iron accumulation and retinal pathology: neuroprotection by diketopiperazines Di Prisco Silvia (Genova) Presynaptic defects in EAE mice at different stages of disease Galizzi Giacoma (Palermo) Autophagic dysfunction: a clue in neurodegenerative diseases and lysosomal storage disorders
5 Giuffrida Maria Laura (Catania) A novel fully water-soluble Cu(I) probe for detection in live cell imaging Grossi Cristina (Firenze) Mediterranean diet and Alzheimer s disease: oleuropein aglycone counteracts Aß toxicity in vivo Gulisano Walter (Catania) The cell adhesion molecule F3/contactin improves synaptic plasticity and memory in aged mice Impellizzieri Agata (Catania) Flavopiridol, an inhibitor of cyclin-dependent kinase 4, reverses memory impairment induced by β-amyloid peptide 1-42 L Episcopo Francesca (Catania) Using transgenic mice with transcriptionally active Wnt/β-catenin signaling for visualization of midbrain dopaminergic (mda) neurons in the MPTP mouse model of Parkinson s disease unveils endogenous β-catenin signaling activation promoting mda neurorestoration Lim Dmitry (Novara) Ca2+-Calcineurin deregulation in Abeta-exposed astrocytes: is it linked to neuronal dysfunction in Alzheimer's disease? Marinelli Carla (Padova) Toll-like receptors as transducer of inflammatory signals in astrocytes Merega Elisa (Genova) Complement selectively evokes glutamate release from nerve terminals in mammal central nervous system Merlo Sara (Catania) 17 -estradiol affects early synaptic changes induced by chronic exposure to -amyloid in organotypic hippocampal slices Muzzi Mirko (Firenze) Ischemic neuroprotection by Dexpramipexole Tomasello Flora (Catania) Confocal imaging of neuronal response to ß-amyloid monomers
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