IRD Room N. State Street Los Angeles, CA Business Phone (323) Westlake High School, Los Angeles, CA

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1 C U R R I C U L U M V I T A E PERSONAL INFORMATION Name in Full Heather Ruth Macdonald Business Address LAC+USC Medical Center IRD Room N. State Street Los Angeles, CA Business Phone (323) EDUCATION High School College or University Internship Residency Fellowship Westlake High School, Los Angeles, CA University of California, Santa Cruz, Crown College Bachelor of Arts, Biology, 1993 Bachelor of Arts, English/American Literature, 1992 Department of Obstetrics & Gynecology Keck School of Medicine University of Southern California, 2000 Department of Obstetrics & Gynecology Keck School of Medicine University of Southern California, 2003 Breast Surgery Keck School of Medicine University of Southern California, 2006 Licensure CA Medical License # A75177 Board Certification American Board of Obstetrics and Gynecology,

2 PROFESSIONAL BACKGROUND Academic and Professional Appointments Visiting Assistant Professor of Clinical OB/GYN and Breast Surgery, Departments of Obstetrics & Gynecology and Surgery, USC Keck School of Medicine, Present Director, Women s Breast Diagnostic Center, LAC+USC Medical Center, 2006 Present Associate Director, Residency Program, Department of Obstetrics & Gynecology: Director of Resident Curriculum Member: Graduate Medical Education Committee, Department of Obstetrics and Gynecology, May 2007-Present Admissions Interviewer, Keck School of Medicine, USC, 2007-present Medical Student mentor, Keck School of Medicine, USC, 2009-present. Medical Staff, Department of Obstetrics & Gynecology, Keck School of Medicine, USC, Clinical Instructor, Department of Obstetrics & Gynecology, Keck School of Medicine, USC, Physician, Obstetrics & Gynecology, California Family Care, Medical Staff, Department of Obstetrics & Gynecology, California Hospital Medical Center, Los Angeles CA, Postgraduate Physician, Department of Obstetrics & Gynecology, Keck School of Medicine, USC, Research Assistant, Institute for Health Policy Studies, University of California, San Francisco, Teaching Assistant, Literature and Creative Writing, University of California, Santa Cruz, Professional Associations American College of Obstetrics and Gynecology, Member American Society of Breast Disease, member Association of Professors of Gynecology and Obstetrics, Member Los Angeles Obstetrics & Gynecology Society American Medical Women s Association, Past President, Student Chapter, Keck School of Medicine, USC Languages English, Spanish 2

3 RESEARCH ACTIVITIES 1. Title: Reliability of Immunoassay Methods for Monitoring SERUM Estradiol Levels During Aromatase Inhibitor Treatment Role: Co-Investigator Status: manuscript in preparation 2. Title: A Randomized Phase III Trial Comparing 16 to 18 Weeks of Neoadjuvant Exemestane (25 mg daily), Letrozole (2.5 mg), or Anastsrozole (1 mg) in Postmenopausal Women with Clinical Stage II and III Estrogen Positive Breast Cancer (American College of Surgeons Oncology Group Z1031) Role: Principal Investigator: David Ota MD (Duke University), Heather R Macdonald MD (USC) Status: hiatus 3. Title: Relationship between DHEAS, and its metabolites and metastatic breast cancer Role: Co-Investigator Status: Enrollment ongoing 4. Title: Does a integrated didactic laparoscopic simulation session impact operative performance, outcomes and confidence for Ob/Gyn PGY 2 residents? Role: Faculty Advisor Status: IRB approval pending 5. Title: 1B-06-9 TARGIT-DCIS Trial Role: Co-Investigator Status: Enrollment ongoing BIBLIOGRAPHY PEER REVIEW JOURNAL PUBLICATIONS 1. Dancz CE, Macdonald HR. Massive Cystic Degeneration of a Pedunculated Leiomyoma. Fertility and Sterility 2008;90(4): Peyre SE, Macdonald HR, Ferro J, Epstein AJ, Randel E, Muderspach LI. Physician- Industry Relationships: An Academic Obstetrics and Gynecology Department Viewpoint. Obstetrics & Gynecology 2008; 111(4S): Macdonald HR, Arias RD. Ductal and Lobular Carcinoma in Situ of the Breast: Histopathology and Significance. The Female Patient 2007, 32(10): Macdonald H, Silverstein MJ, Sanghavi P, Lee L, Holmes D, Silberman H, Epstein M, Lagios M. Margin Width As The Sole Determinant of Local Recurrence After Breast Conservation in Patients With Ductal Carcinoma In Situ of the Breast. American Journal of Surgery 2006; 192(4):

4 5. Macdonald H, Silverstein MJ, Mabry H, Holmes D, Epstein M, Moorthy B, Silberman H, Lagios MD. Local Control in DCIS Treated by Excision Alone: Incremental Benefit of Larger Margins. American Journal of Surgery 2005; 190: Lee L, Silverstein MJ, Sanghavi P, Macdonald H, Holmes D, Epstein M, Silberman H. Breast Cancer Mortality After Invasive Local Recurrence in Patients with Ductal Carcinoma in Situ (DCIS) of the Breast. American Journal of Surgery 2006; 192(4): Amezcua CA, Macdonald H, Lum CA, Yi W, Muderspach LI, Roman LD, Felix JC. Endometrial Cancer Patients Have A Significant Risk of Harboring Isolated Tumor Cells in Histologically Negative Lymph Nodes. International Journal of Gynecologic Cancer 2006; 16: Macdonald H, Aguinaga S, Glantz S. The Defeat Philip Morris California Uniform Tobacco Control Act. American Journal of Public Health 1997; 97: CHAPTERS 1. Macdonald H. Breast Disorders. In: Common Problems in Obstetrics & Gynecology. In press. 2. Macdonald H. Adolescent Breast Disorders. In: Adolescent Health Care, A Practical Guide, 5 th Edition. Neinstein L, ed. Lippincott, Williams & Williams Silverstein MJ, Macdonald H, Mabry H, Moorthy B. Ductal Carcinoma In Situ of the Breast. In: Winchester DJ, Norton L, Hudis CA, Winchester DP, eds. Breast Cancer, 2 nd Ed. BC Decker, Hamilton, Ontario, Canada ABSTRACTS AND POSTERS 1. Lacour R, Westin SN, Daniels MS, Meyer LA, Choubey V, Blank SV, Macdonald HR, Roman L, Estes JM, Barnes M, Tegh D, Powell BA, Wingo SN, Schorge JO, Brooks R, Mutch D, Babb S, Sun CC, Urbauer DL, Ramirez PT, Gershenson DM, Lin KH. Do BRCA Mutations Confer a Survival Advantage in All Cases of Advanced Stage Ovarian Cancer? Society of Gynecologic Oncologists, Annual Meeting, Florida March Datta N, Peyre SE, Macdonald H, Kwok L, Muderspach L. A Resident Research Curriculum Improves Obstetric and Gynecology Resident Scholarly Activity. Association of Professors in Gynecology and Obstetrics/Council on Resident Education in Obstetrics and Gynecology, Annual Meeting, Peyre SE, Datta N, Macdonald H, Lee R, Templeman C, Muderspach L. Do Obstetrics and Gynecology Residents accurately self-assess technical skill using global rating scales? Association of Professors in Gynecology and Obstetrics/Council on Resident Education in Obstetrics and Gynecology, Annual Meeting, Peyre SE, Macdonald H, Ferro J, Epstein A, Randel E, Muderspach L. Physician-Industry Relationships: An Academic Obstetrics and Gynecology Department Viewpoint. American College of Obstetrics and Gynecology, Annual Meeting,

5 5. Peyre SE, Macdonald H, Kwok L, Chandarvarkar U, Schaab J, Muderspach L. Situational Leadership:OB/GYN Resident Retreat Curriculum. Innovations in Medical Education, Annual Meeting, Macdonald H, Ye W, Lee LA, Holmes DR, Guerra L, Rivers L, Silverstein MJ. Significant Association between Estrogen Receptor Status and Progesterone Receptor Status and Bloom-Richardson-Scarff Score in Patients with Infiltrating Ductal Carcinoma of the Breast. American Society of Breast Surgeons. May Macdonald H, Silverstein MJ, Sanghavi P, Lee L, Holmes D, Silberman H, Epstein M, Lagios M. Margin Width as the Sole Determinant of Local Recurrence after Breast Conservation in Patients with Ductal Carcinoma in Situ of the Breast. American Society of Breast Surgeons 8 th Annual Meeting Macdonald H, Mabry H, Holmes D, Epstein M, Moorthy B, Silberman H, Lagios MD, Silverstein MJ. Local Control in DCIS Treated by Excision Alone: Incremental Benefit of Larger Margins. American Society of Breast Surgeons Lee L, Silverstein MJ, Sanghavi P, Macdonald H, Holmes D, Epstein M, Silberman H. Breast Cancer Mortality after Invasive Local Recurrence in Patients with Ductal Carcinoma in Situ (DCIS) of the Breast. American Society of Breast Surgeons 8 th Annual Meeting Sanghavi P, Lee L, Macdonald H, Holmes D, Silberman H, Silverstein MJ. Outcome in Augmented Patients who Subsequently Develop Breast Cancer. American Society of Breast Surgeons 8 th Annual Meeting Moorthy B, Mabry, H, Epstein, M, Macdonald H, Holmes D, Silberman H, Lewinsky, B, Streeter O, Lagios MD, Silverstein MJ. Radiation Effectiveness Depends on Margin Width in Patients with DCIS American Society of Breast Surgeons Mabry H, Holmes D, Macdonald H, Epstein M, Moorthy B, Silberman H, Lagios MD Silverstein, MJ. What is the Value of Axillary Dissection or Sentinel Node Biopsy in Patients with Ductal Carcinoma in Situ (DCIS)? American Society of Breast Surgeons EDITORSHIPS 1. Continuing Care for Women with Breast Cancer. Clincal Updates in Women s Health Care. American College of Obstetrics & Gynecology. April AWARDS AND ORAL PRESENTATIONS 1. Faculty Teaching Award, Outstanding Teaching as a House Officer, Keck School of Medicine, University of Southern California, August 25, Margin Width as the Sole Determinant of Local Recurrence after Breast Conservation in Patients with Ductal Carcinoma in Situ (DCIS) of the Breast. Macdonald H, Sanghavi P, Lee A, Holmes D, Silberman H, Epstein M, Lagios M, Silverstein M. Presented American 5

6 Society of Breast Surgeons, Baltimore MD, April Winner George Peters Award, Best Fellow Presentation. 3. Local Control in DCIS Treated by Excision Alone: Incremental Benefit of Larger Margins. Macdonald H, Ye W, Mabry H, Moorthy B, Holmes D, Silberman H, Lagios M, Silverstein M. Presented American Society of Breast Surgeons, March 2005, Los Angeles CA. Winner, George Peters Award, Best Fellow Presentation. 4. Correlation of Micrometastases and Cancer Recurrence in Endometrial Cancer. Macdonald H, Felix JC, Muderspach L, Lum C, Morrow C, Roman L, O Meara A, Burnett A, Yi W, Amezcua C. Presented University of Southern California, Department of Obstetrics and Gynecology Residents Scientific Forum, May Honors, BA English/American Literature, University of California, Santa Cruz, December GRAND ROUNDS AND LECTURES 1. Panelist, Breast Cancer Update: State of the Art for the Primary Physician. Norris Comprehensive Cancer Center, University of Southern California. December USC Refresher Course in Medicine and Current Clinical Issues in Women s Health. Invited Faculty. Maui, Hawaii. August Topics: Breast Masses: Approach with Caution, LCIS/DCIS: What a Gynecologist Needs to Know, Women Treated for Breast Cancer:Gynecologic Considerations, Clinically Relevant Risk Factors for Breast Cancer. 3. Global Health Issues of Women in Adulthood. Invited Lecturer. Masters in Preventative Medicine: Global Health. July Gynecologic Care of the Breast Cancer Patient. Grand Rounds, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California. June Faculty Lecturer, Department of Obstetrics & Gynecology, Keck School of Medicine, University of Southern California (recurrent) present. Topics: Benign Breast Disease, Breast Cancer 101, Sleep Deprivation, Risk Management. 6. Faculty lecturer, Departments of Obstetrics & Gynecology and General Surgery, Keck School of Medicine, University of Southern California Medical Student Year III clerkships (recurrent) present. Topics: Benign Breast Disease, Breast Cancer Patient Care Conference. 7. USC Refresher Course in Medicine and Current Clinical Issues in Women s Health. Invited Faculty. Maui, Hawaii. August Topics: Treatment of Benign and Malignant Breast Disease with Minimally Invasive Surgical Techniques, Management of Lobular Carcinoma in Situ and Ductal Carcinoma in Situ of the Breast, Management of Patients with Hereditary Increased Risk of Developing Breast and Ovarian Cancer, Methods to Reduce Risk of Developing Breast Cancer. 8. Breast Health in Adolescence. Grand Rounds: Providence/St Joseph s Medical Center, October 19, 2006; Grand Rounds: Department of Pediatrics, University of Southern 6

7 California, October 24, 2006; Grand Rounds, Department of Obstetrics & Gynecology, Keck School of Medicine, University of Southern California, October 27, Local Control in DCIS Treated by Excision Alone: Incremental Benefit of Larger Margins. Grand Rounds, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California. May