School of Pharmacy and Pharmaceutical Sciences: Research. Anne Marie Healy Head of School 04/02/2015
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1 School of Pharmacy and Pharmaceutical Sciences: Research Anne Marie Healy Head of School 04/02/2015
2 Pharmaceutical Pharmacists Technologists Pharmacologists Pharmacy Practitioners Pharmaceutical/Medicinal Biotechnologists Chemists Pharmacognosists MDs/Clinicians New Drugs: de novo synthesis or from nature Disease, Drug Mechanisms & Safety Cancer Research Pharmaceutics & Pharmaceutical Technology Clinical Pharmacy & Pharmacy Practice R BIRTH Brain Imaging Return to Health
3 New Drugs: de Novo Synthesis or from Natural Products De Novo Synthesis» Design, synthesis and evaluation of molecular structures as potential anti-cancer drugs» Pro-drug optimisation of our current candidates» Dual targeting drugs e.g. ER/aromatase, tubulin/aromatase» Design of multi-drug resistance modulators HO O O O HO O From Natural products» Anti-cancer lead discovery from natural sources» Ethno-medicine & evidence-based traditional Chinese medicine» Cross-hybridisation of natural molecules as anti-cancer scaffolds
4 Disease, Drug Mechanism & Safety» Platelet pathology and pharmacology of anti-platelet drugs» Nanopharmacology» Nanotoxicology soluble & surface-bound nanoparticles» Pathophysiology and experimental therapeutics of inflammatory diseases» Drug efficacy, toxicity & ADR evaluation Nanoparticle-platelet interaction (AFM) Nanoparticle-platelet interaction (SEM)
5 Cancer Research Probability. Some target discovery Pipeline drug evaluation: anti-cancer potential Phase I : Basic in vitro screening +/-chemo +/-targeted Phase II Advanced In Vitro Screening In Vivo Studies Translational Clinical Trials (Phase I&II)» Target identification & validation» Anti-cancer drug development» Re-purposing old drugs» Molecular mechanisms: cancer development & drug resistance» Diagnostic, prognostic & drug-companion biomarkers» Exosomes & platelets in cancer angiogenesis, metastasis, drug-resistance» Nano-delivery of anti-cancer agents» Pharmaco-kinetics & -dynamics of anti-cancer drugs» Clinical trials design & development: Phase I & II NmU (-) P= NmU(+) Time (month)
6 Pharmaceutics & Pharmaceutical Technology» Design, production and evaluation of advanced drug delivery systems Optimisation of formulations for poorly soluble drugs» Advancing conventional formulation & manufacturing of solid dosage form medicinal products Nano-sized delivery systems for small and macro-molecules Pharmaceutical salts and cocrystals Formulation of lipid-based delivery systems Identification of absorption pathways Pulmonary drug delivery Drug disposition after pulmonary administration Drug-transporter interactions» Dissolution testing and simulation Particle engineering by spray drying for pulmonary delivery Epithelial cells for drug absorption studies Molecule Material Medicine
7 Clinical Pharmacy & Pharmacy Practice» Clinical pharmacy & pharmaceutical care of vulnerable groups» Pharmacy practice, medication use and patient safety» Health services research & evidence-based practice» Clinical pharmacokinetics-pharmacodynamic: patient- & disease - related effects on distribution/ elimination» Pharmaco-epidemiology, pharmaco-economics & pharmaco-vigilance» Healthcare law, regulation & professional ethics in pharmacy practice» Educational research, workplace learning & technology-enhanced learning Health Policy, Regulation & Population health Professional education & training Pharmaceutical care for vulnerable patient groups Optimise medication use Primary & secondary care pharmacy
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