YEAR OF ESTABLISHMENT TYPE OF ACTIVITY DANISH BIOTECH COMPANIES

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1 DANISH BIOTECH COMPANIES YEAR OF ESTABLISHMENT TYPE OF ACTIVITY COMPANY FOCUS AREA CONTACT INFORMATION Acadia Pharmaceuticals A/S 1997 R&D ACE Biosciences A/S 2000 R&D Action Pharma A/S 2000 R&D AgroFerm A/S 2002 Drug discovery and clinical development of novel treatments for schizophrenia, Parkinson's disease, and other central nervous system disorders. Develops novel, protein-based vaccines and antibodies to address infectious diseases caused by pathogens such as bacteria, fungi and viruses. New drugs and treatment concepts within cardiovascular diseases associated with ischemia and inflammation. Produces lysine to the feedstuff industry utilizing residues from the agro industry and agricultural plant products. Acadia Pharmaceuticals A/S, Bredgade 38, 1260 København K Tel ACE BioSciences A/S, Unsbjergvej 2a, 5220 Odense SØ, Tel Action Pharma A/S, Science Park Åarhus, Brendstrupgårdsvej 102, 8200 Århus N, Tel AgroFerm A/S, Limfjordsvej 4, 6715 Esbjerg N, Tel Alk-Abello A/S 1960 Develops and produces products for diagnosis, prevention and treatment of allergies. ALK-Abelló A/S, Bøge Alle 6-8, 2970 Hørsholm, Tel Alkalon ApS 2007 Development Alpharma ApS 1959 A pharmaceutical development company engaged in development, registration and commercialization of new generic OTC-products for the pharmaceutical industry. Produces active pharmaceutical ingredients (APIs) as well as sterilized drugs. Antibody project ApS 2006 R&D Focuses on supply of polyclonal antibodies Alkalon ApS Trojborggade 3A, 1757 Copenhagen Tel Alpharma ApS, Dalslandsgade 11, P.O. Box 1736, 2300 København S, Tel The Antibody Project ApS, Kullingegade 31, 5700 Svendborg, Tel

2 Aresa A/S 2001 R&D Arpida A/S 2000 R&D Ascendis Pharma A/S 2007 R&D Astion Pharma A/S 2002 R&D Atonomics A/S 2000 R&D Baxter A/S 1983 Combines molecular biology and plant physiology with disciplines like protein chemistry with focus on lancing plant-based solutions and products. Discovery and development of novel products for the treatment of severe bacterial infections. Improving drugs by using a transient linker technology, TransientLink, which conjugates peptides, proteins and small molecules to a carrier molecule in a reversible fashion which allows an unmodified active drug to be released in the body in a precise fashion. Researches in safe and effective relief for patients suffering from dermatological diseases with focus on development of antiinflammatory substances. Electro- and nano mechanical diagnostic Point of Care technologies. Develop biochip products. Produces pharmaceuticals and medico equipment used in the treatment of patients with immunodeficiency, infectious diseases, cancer, kidney diseases and trauma. Aresa A/S, Fruebjergvej 3, 2100 København Ø, Tel Arpida A/S, Vesterbrogade 188, 1800 Frederiksberg C, Tel Ascendis Pharma A/S Tuborg Boulevard 12, 2900 Hellerup Tel Astion Pharma A/S, Fruebjergvej 3, 2100 Copenhagen, Tel Atonomics A/S, Vestre Teglgade 10, 2450 Copenhagen, Tel Baxter A/S, Gydevang 43, 3450 Allerod, Tel Bavarian Nordic A/S 1994 Develops and produces innovative vaccines to prevent and treat infectious diseases: smallpox, HIV and cancer. Bavarian Nordic A/S, Bøgeskovvej 9, 3490 Kvistgård, Tel: Bifodan A/S 1987 BioGasol ApS 2006 R&D Develops and produces probiotic products and other preparations for human and veterinary use. Bifodan is specialised in handling lactic acid bacteria. Develops and designs technologies needed for second generation bioethanol production. BioGasol s process technology is innovative and offers a cost effective production of biofuels such as bioethanol, hydrogen, methane and other valuable byproducts. Bifodan A/S, Bogbinderivej 6, 3390 Hundested, Tel: BioGasol ApS Technical University of Denmark, Building Lyngby Tel:

3 Biogen Idec Manufacturing ApS 2001 Research and development within oncology, neurology and immunology. Biogen Idec Manufacturing ApS, Biogen Idec Allé 1, 3400 Hillerød, Tel BioLocus A/S 1999 R&D Develops a technology that makes it possible to replace biocides in anti-fouling paints for boats, ships and offshore constructions with enzymes. BioLocus A/S, Agern Allé 3, 2970 Hørsholm, Tel Biomonitor ApS 2003 service Develops clinically useful methods to monitor therapies with cytokine-modulating biopharmaceuticals and to reveal and prevent immunogenic properties of biopharmaceuticals. Biomonitor ApS, Fruebjergvej 3, 2100 Copenhagen Ø, Tel BioPorto Diagnostics A/S 2000 Development, diagnostic BioPorto develops and markets antibodies and antibody-based products, including tests to diagnose human disease. The Company s developments include a test (NGAL) to diagnose and monitor acute kidney damage. BioPorto Diagnostics A/S, Grusbakken 8, 2820 Gentofte Tel BKG Pharma ApS 2004 R&D Borean Pharma A/S 1997 R&D BSP Pharma A/S 2001 R&D Develops novel therapies against human pathogenic multiresistant bacteria. A drug discovery and development company focused on recombinant protein technology. Focuses on relieving the symptoms of eczema, arthritis and muscle pain, psoriasis and herpes simplex based on natural products. BKG-Pharma ApS, Vintervej 2, 2920 Charlottenlund, Tel /not active Borean Pharma A/S, Gustav Wieds Vej 10, 8000 Aarhus C, Tel BSP Pharma A/S, M.P. Bruuns Gade 27, 8000 Aarhus C, Tel Center for Clinical and Basic Research A/S 1992 R&D Basic and applied research in biology related to diseases in the years after menopause, especially osteoporosis and other bonerelated diseases. CCBR A/S, Ballerup Byvej 222, 2750 Ballerup, Tel Chr. Hansen A/S 1874 Develops natural ingredient solutions for the food, pharmaceutical, nutritional and agricultural industries. Chr. Hansen A/S, Boege Alle 10-12, 2970 Hoersholm, Tel

4 CLC bio A/S 2004 R&D CMC Biopharmaceuticals A/S 2001 Cobento Biotech A/S 2001 service Colotech A/S 1999 R&D Develops bioinformatic software based on the latest scientific developments in bioinformatic. A Contract Manufacturing Organization offering manufacturing services using microbial fermentation and mammalian cell culture processes. Produces recombinant human intrinsic factor and recombinant human transcobalamin to improve the diagnosis and treatment of vitamin B12 deficiency. Develops innovative drugs for the prevention and treatment of human cancers and its precursors. Como Biotech ApS 2000 R&D Works with proteins for diagnostic/therapeutic purposes. CLC bio A/S, Science Park Aarhus, Gustav Wieds Vej 10, 8000 Aarhus C, Tel: CMC Biopharmaceuticals A/S, Vandtaarnsvej 83, 2860 Soeborg, Tel Cobento Biotech A/S, Science Park Aarhus, Gustav Wieds Vej 10, 8000 Aarhus C, Tel Colotech A/S, Copenhagen Science Park, Fruebjergvej 3, 2100 Copenhagen, Tel Como Biotech ApS, c/o Østjysk Innovation A/S, Gustav Wieds Vej 10, 8000 Århus C, Tel: Copenhagen Biotech Assets ApS 2002 R&D Discovery within the area of protein misfolding, novel Bovine Spongiforme Encephalopathies (BSE) diagnostic assays and novel drugs against BSE and Alzheimer s disease. Copenhagen Biotech Assets ApS, Caroline Mathilde Vej 11, 2950 Vedbæk, Tel Curalogic A/S 2004 R&D The primary therapeutic focus is the worldwide allergic rhinitis mark. Curalogic A/S, Amagertorv 29A, 4th floor, 1160 Copenhagen K, Tel Cym1P A/S 2003 R&D Enhanced production of recombinant peptides. Cym1P A/S, Niels Jernes Vej 10, 9220 Aalborg Øst, Tel

5 CytoGuide ApS 2007 R&D Cytotech ApS 1989 DanDrit Biotech A/S 2001 R&D Danisco A/S 1989 Direct-Haler A/S 1994 R&D DNA Technology A/S 1992 R&D service Drugrecure ApS 2007 Development Egalet A/S 1987 R&D Develops two-component drugs which target specific receptors on cells of the immune system, and by means of these receptors ensure efficient uptake of the drug where it is needed. Main focus area is inflammatory disease. of animal and normal human cell systems and related media for in vitro research, serum-free and customized media, sera, growth factors and supplements. Develops cancer vaccines aimed at improving the patients immune response against solid tumours and their metastases. Produce ingredients for the food industry. The company s broad technology platform and product portfolio include emulsifiers, enzymes, stabilisers, cultures, flavours, sugar and sweeteners. Research and development of drug delivery device technology, and novel therapeutic approaches involving pulmonary and nasal delivery. Manufactures customer defined oligonucleotides. Research and development is focused on a product line comprised by molecular human diagnostic systems. Files use-patents on well known already approved and marketed drugs in new indications for treatment of critical ill patients. The company s highest priority is the Granulocyte Macrophage Colony Stimulationg Factor (GM-CSF) project Focus on the formulation and development of controlled release products. CytoGuide ApS Gustav Wieds Vej 10, 8000 Århus C Tel Cytotech ApS, Nordre Strandvej 119F, 3150 Hellebaek, Tel DanDrit Biotech A/S, Fruebjergvej 3, Box 62, 2100 Copenhagen, Tel Danisco A/S, Langebrogade 1, 1001 Copenhagen, Tel Direct-Haler A/S, Fruebjergvej 3, 2100 Copenhagen, Tel DNA Technology A/S, Science Park Aarhus, Gustav Wieds Vej 10A, 8000 Aarhus C, Tel Drugrecure ApS Agern alle 3, Scion-DTU, 2970 Hørsholm Tel Egalet A/S, Lejrvej 37-41, 3500 Vaerløse, Tel Eldon Biologicals A/S 1993 Produces blood type determining cards. Eldon Biologicals A/S, Sandtoften 10, 2820 Gentofte, Tel

6 Enfutech ApS 2007 Development Using Retrovec s license for development of potential treatment of HIV patients Enfutech ApS Gustav Wieds Vej 10, 8000 Århus C Tel ENKAM Pharmaceuticals A/S 2000 R&D Works within the field of neural cell adhesion molecules and has a focus on neurodegenerative disorders and cancer. ENKAM Pharmaceuticals A/S, Fruebjergvej 3, Box 58, 2100 Copenhagen Ø, Tel Entrop Pharma A/S 2007 R&D Development of pharmaceuticals against inflammation. Entrop Pharma A/S Østergade 5, København K Evolva Biotech A/S 2001 R&D Uses genetic engineering to evolve small molecule drugs. Evolva Biotech A/S, Bülowsvej 25, 1870, Frederiksberg C, Tel Exiqon A/S 1996 Develops immuno- and molecular genetic-diagnostics, based on immobilization of biomolecules to surfaces and locked nucleic acids. Exiqon A/S, Bygstubben 9, 2950 Vedbaek, Tel FCMB ApS 2005 R&D Develops and commercialises a novel platform that can be used for non-invasive prenatal diagnostics. FCMB ApS, Tysklandsvej 7, 7100 Vejle Tel Ferring Pharmaceuticals A/S 1992 Develops products in the fields of urology, gynaecology and obstetrics, gastroenterology and endocrinology. Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11, 2300 Copenhagen S, Tel Fertin Pharma A/S 2001 Develops medical chewing gum. Fertin Pharma A/S, Industrivej 8, 7120 Vejle, Tel Fisher BioImage A/S 1998 R&D service Develops proprietary assays for the monitoring of protein translocations in living cells. These assays are sold to biopharmaceutical companies that are engaged in drug discovery. BioImage A/S, Moerkhoej Bygade 28, 2860 Soeborg, Tel

7 Fluxome Sciences A/S 2002 R&D Forward Pharma A/S 2005 R&D Develops innovative and cost-effective bioprocesses by employing metabolic engineering. Develops immunomodulatory drugs for the treatment of a range of common disorders. Main focus is dermatology. Fluxome Sciences A/S, Diplomvej 378, 2800 Kgs. Lyngby, Tel Forward Pharma A/S, Østergade 5, 3, 1100 Copenhagen K, Tel: Gastrotech Pharma A/S 2003 R&D Develops therapeutics based on gastrointestinal peptide hormones. Genmab A/S 1999 R&D Develops human antibodies for the treatment of cancer, infectious disease, rheumatoid arthritis and other inflammatory conditions. Genobiotix ApS 2004 R&D Develops new antibiotics against multi-resistant bacteria. Gastrotech Pharma A/S, Nyhavn 43B, 1051 Copenhagen K, Tel Genmab A/S, Toldbodgade 33, P.O. Box 9068, 1253 Copenhagen K, Tel Genobiotix ApS, Forskerparken 10, 5230 Odense / not active GlycaNova A/S 2002 Glycom ApS 2005 R&D H. Lundbeck A/S 1915 Hypo-Safe 2005 R&D Develops a production technology based on cultivation of medicinal mushrooms in submerged culture. The method can be utilised to manufacture a number of different immune stimulating agents. Engaged in the preparation of novel biomolecules for the pharmaceutical and food industries. Applies multifunctional molecular engineering and advanced peptide and protein engineering. Develops new drugs for treatment of CNS disorders, including depression, schizophrenia, Alzheimer s disease and Parkinson s disease. Pioneering cognitive technologies designed to help and empower people. They create tiny implants that monitor brain activity to convey relevant information and issue alerts, and are currently clinically testing the world s first EEG monitoring device for diabetics unable to feel and respond to a critical low blood sugar level. GlycaNova A/S, Innovation Centre, Agern Allé 3, 2970 Hørsholm, Tel Glycom ApS, Diplomvej 373, 2800 Kgs. Lyngby, Tel H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Tel Hypo-Safe A/S, Diplomvej 381, 2800 Kgs. Lyngby Tel

8 Ilochip A/S 2001 R&D Inagen A/S 2007 R&D Interface Biotech A/S 1998 R&D LEO Pharma A/S 1908 LICA Pharmaceuticals A/S 2000 R&D LifeCycle Pharma A/S 2002 R&D LiPlasome Pharma A/S 2001 R&D Maxygen ApS 1999 R&D Develops a micro-device, which provide remote, reliable and rapid detection of biological warfare agents. Development of drugs against virus infections, especially Cytomegalovirus. The drugs consist of toxins bound to signal molecules specifically taken into virus infected cells. An orthopaedic oriented biotech company specialized in culturing human cells for cartilage and bone repair. Researches and develops small molecule drug candidates within the fields of dermatology, cardiovascular diseases, antithrombotics, antibiotics, and bone metabolism. Develops novel compounds for the treatment of bacterial and parasitic diseases such as hospital-acquired infections, gastric ulcer and malaria. Develops a drug delivery technology platform for dramatically enhancing the bioavailability of compounds with low water-solubility. Develops novel prodrug and drug delivery systems based on nanocarriers for targeted delivery of anticancer drugs. Develops protein based pharmaceuticals through structure-based analysis and robotic screening of candidate molecules. Ilochip A/S, Stroemmen 6, 9400 Noerresundby, Tel Inagen Aps c/o Risøe National Laboratory Frederiksborgvej 399, Building 330, 4000 Roskilde Interface Biotech A/S, Venlighedsvej 6, 2970 Hørsholm, Tel LEO Pharma A/S, Industriparken 55, 2750 Ballerup, Tel LICA Pharmaceuticals A/S, Fruebjergvej 3, 2100 Copenhagen, Tel LifeCycle Pharma A/S, Kogle Allé 4, 2970 Hørsholm, Tel LiPlasome Pharma A/S, Technical University of Denmark, Building 207, 2800 Lyngby, Tel Maxygen ApS, Agern Allé 1, 2970 Hørsholm, Tel MediCult A/S 1987 Develops new and existing techniques within fertility treatment. MediCult A/S, Møllehaven 12, 4040 Jyllinge, Tel

9 Microlytic ApS 2006 R&D Molegro ApS 2005 R&D MycoTeQ A/S 2006 R&D Focuses on microfungi. develops microfluidic technology to speed up the structure determination pipeline for crystallographers. Develops high-performance drug discovery software solutions leading to a faster drug-development process. Microlytic ApS, Universitetsparken 7, 4000 Roskilde, Tel Molegro ApS, Høegh-Guldbergs Gade 10, Building 090, 8000 Aarhus C, Tel MycoTeQ A/S, Søltofts Plads 221, 2800 Kgs. Lyngby, Tel NatImmune A/S 2000 R&D Neurokey A/S 2007 R&D NeuroSearch A/S 1988 R&D Develops protein-based therapeutics for the prevention and treatment of infectious diseases and inflammation. Develops drugs for the critical care segment. Neurokey products are based on both original ideas and in-licensing. Diseases in the Central Nervous System and other diseases treated primarily through ion channel modulation, including compounds for the treatment of ADHD, cancer, epilepsy, and Parkinson's disease. NatImmune A/S, Fruebjergvej 3, box 3, 2100 Copenhagen Ø, Tel Neurokey A/S Diplomvej 381, 2800 Lyngby Tel NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Tel Nordic Bioscience A/S 1998 Develops therapeutic compounds and diagnostic products for diseases affecting bone and cartilage, such as osteoporosis, osteoarthritis and bone metastasis. Nordic Bioscience A/S, Herlev Hovedgade 207, 2730 Herlev, Tel Nordic Vaccine A/S 2001 R&D Develops vaccines for prophylactic as well as therapeutic use. Focused on vaccines for infectious diseases, DNA-delivery technologies for use in therapeutic DNA-vaccines and gene therapy. Nordic Vaccine A/S, Fruebjergvej 3, 2100 Copenhagen Ø, Tel Nota Bene Scientific Aps 1990 Produces antibodies and other immunology reagents. Nota Bene Scientific ApS, Nordre Strandvej 119F, 3150 Hellebaek, Tel

10 Novo Nordisk A/S 1923 Focuses on diabetes treatment and insulin delivery systems. The company is also involved within areas such as haemostasis management, growth hormone therapy and hormone replacement therapy. Novo Nordisk A/S, Novo Allé, 2880 Bagsværd, Tel Novozymes A/S 1941 Focused on microbiology, biotechnology and gene technology. Develop and refine enzymes and microorganisms to improve industrial performance. Novozymes A/S, Krogshoejvej 36, 2880 Bagsvaerd, Tel: NSexplorer A/S 2002 R&D Focuses on new mechanisms for the treatment of tension type headache. NSexplorer A/S, Pederstrupvej 93, 2750 Ballerup, Tel NsGene A/S 1999 R&D Nuevolution A/S 2001 R&D Develops novel cell and gene based products for the treatment of neurological diseases such as Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain. Develops a unique drug discovery technology that enables the rapid synthesis and screening of many billions of drug-like molecules in a single test tube. NsGene A/S, Baltorpvej 154, 2750 Ballerup, Tel Nuevolution A/S, Rønnegade 8, 2100 Copenhagen, Tel Oncotac Pharmaceuticals ApS 2002 R&D Develops products for cancer treatment and a new drug delivery system. Osteologix A/S 2003 R&D Develops pharmaceutical products for bone and cartilage disorders. Pentabase ApS 2006 Real time PCR technology Pharma 2100 ApS 2004 R&D Develops products for wound treatment. Oncotac Pharmaceuticals ApS, Fruebjergvej 3, 2100 Copenhagen Ø / not active Osteologix A/S, Fruebjergvej 3, box 4,2100 Copenhagen Ø, Tel Pentabase ApS, Sunekaer 1, 5471 Soendersoe, Tel Pharma 2100 A/S, Fruebjergvej 3, 2100 Copenhagen Ø

11 Pharmacosmos A/S 1965 Manufactures and develops intravenous iron infusion and iron injection compounds and Dextran carbohydrate polymers, which are essential in the treatment of anaemia in humans. Pharmacosmos A/S, Rørvangsvej 30, 4300 Holbæk, Tel Pharmaorigin ApS 2007 Development Pharmexa A/S 1990 R&D Files use-patents on well known already approved and marketed drugs in new indications for treatment of critical ill patients. The company focuses on Factor VIIa to treat diffuse alveolar hemorrhage. Develops new immunotherapy drugs for the treatment of cancer and inflammatory diseases. Pharmaorigin ApS Agern alle 3, Scion-DTU, 2970 Hørsholm Tel Pharmexa A/S, Kogle Allé 6, 2970 Hoersholm, Tel Pharmos Bioscience A/S 2004 R&D Focused on bone diseases. Pharmos Bioscience A/S, Ballerup Byvej 222, 2750 Ballerup, Tel Pipeline Biotech A/S 1999 R&D service PK Chemicals A/S 1991 A pharmacological contract research organisation with the capacity to combine advanced molecular biology with pre-clinical research, aimed at drug discovery and early drug development. Manufactures Dextran derivatives and other carbohydrate-based chemicals. Pipeline Biotech A/S, Roevedvej 1, 8380 Trige, Tel PK Chemicals A/S, Koebenhavnsvej 140, 4600 Koege, Tel Poalis A/S 2001 R&D Develop biological production processes for aromas and other high value chemicals. Poalis A/S, Kirkeleddet 125, 3480 Fredensborg, Tel Poseidon Pharmaceuticals A/S 2001 R&D Research and development is aimed at new therapies for diseases outside the CNS area. Poseidon Pharmaceuticals A/S, Pederstrupvej 93, 2750 Ballerup, Tel PreciSense A/S 1995 R&D Develops non-invasive and accurate glucose reading products. PreciSense A/S, Dr. Neergaards Vej 3, 2970 Hørsholm, Tel

12 ProteoTarget ApS 2002 R&D Develops a novel phage display technology platform to accelerate drug discovery and to allow targeting of intracellular proteins. ProteoTarget ApS, Tranbjerg Stationsvej 1, 8310 Tranbjerg J, Tel.: Prozymex Pharmaceuticals A/S 1999 R&D Researches in DPPI and DPPI inhibitors for disease treatment. ProZymex Pharmaceuticals A/S, Dr. Neergaards Vej 17, 2970 Hørsholm, Tel QSI Pharma A/S 2002 R&D Researches in Quorum Sensing Inhibitors. Treatment to reduce the risk of developing resistant bacteria strains in patients enrolled in long-term treatment with antibiotics. QSI Pharma A/S, Søltofts Plads, 2800 Kongens Lyngby, Tel Quantibact A/S 2004 R&D New method for measuring the number and the sort of bacteria in urine. Quantibact A/S, Kettegårs Allé, 2650 Hvidovre RAM Biotech ApS 2003 R&D ReceptIcon ApS 2001 R&D Develops therapeutical anti-malaria antibodies with the potential to eliminate the malaria parasite at the merezoite stage. Focuses on discovery of receptors in the kidney that are responsible for renal uptake and nephrotoxicity of some of the most commonly used therapeutics worldwide. Ram Biotech ApS, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Tel ReceptIcon ApS, Gustav Wieds Vej 10, 8000 Aarhus C, Tel: RetroVec ApS 2004 R&D Develops retroviral gene transfer technology. RetroVec ApS c/o Østjysk Innovation A/S, Gustav Wieds Vej 10, DK 8000 Århus C, Tel Rheoscience A/S 2002 R&D service Researches within the fields of diabetes and obesity. Provides preclinical contract research and clinical development consultancy. Rheoscience A/S, Glerupvej 2, 2610 Roedovre, Tel RiboTask ApS 2006 Service Offers RNA- and LNA-based products to companies within biotechnology and to academic research laboratories. The products down regulate disease-promoting genes and hereby stop the development of the sick cells. RiboTask ApS Sdr. Boulevard 44, 3. sal, 5000 Odense C, Tel

13 Sanos Bioscience A/S 2003 R&D Santaris Pharma A/S 2003 R&D Focuses on diseases involving skeletal wasting such as osteoporosis. Develops cancer treatments using high affinity LNA antisense chemistry. Sanos Bioscience A/S, Glerupvej 2, 2610 Roedovre, Tel Santaris Pharma A/S, Bøge Allé 3, 2970 Horrsholm, Tel Schafer-N ApS 1995 Synthesizes custom defined peptides. SD Genomics A/S 2006 Service Senetek Denmark ApS 2005 R&D Specializes in providing biotechnological products and services including oligonucleotides, sequencing services, bioinformatics services, and microarrays. Development of products in both the anti-aging and sexual dysfunction categories. SKAUvaccine ApS 2007 Development Using Retrovec s license for development of a potential HIV vaccine Schafer-N ApS, Lersø Park Allé 42, 2100 Copenhagen, Tel SD Genomics A/S, Science Park Aarhus, Gustav Wieds Vej 10, 8000 Aarhus C, Tel Senetek Denmark ApS, Gustav Wieds Vej 10, 8000 Aarhus C SKAUvaccine ApS Gustav Wieds Vej 10, 8000 Århus C Tel Soilrem A/S 1986 Biotechnological cleaning of contaminated soil by bioremediation, electro dialysis and organic solvents. Bioteknisk Jordrens Soilrem A/S, Maglehøjvej 10, 4400 Kalundborg, Tel Sophion Bioscience A/S 2000 Microchip-based automated patch clamp systems. Sophion Bioscience A/S, Baltorpvej 154, 2750 Ballerup, Tel Spree Pharma A/S 2007 Development Spree Pharma uses iceutica s proprietary Encapsulated Organic Nanoparticle Platform to reformulate a number of compounds for launch and marketing in focused therapeutic indications. Spree Pharma A/S Østergade 5, København K

14 Statens Serum Institut 1902 Prevents and controls infectious diseases, biological threats, and congenital disorders. Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Tel Stevia ApS 2001 R&D Develops a pharmaceutical therapy for diabetes type 2 and the metabolic syndrome, based on molecular structures found in the plant stevia rebaudiana. Stevia ApS, Sponnecksvej 4, 2820 Gentofte, Tel Symphogen A/S 2000 R&D Develop recombinant human polyclonal antibodies. TAG Copenhagen A/S 1996 TopoTarget A/S 2000 R&D Unizyme Laboratories A/S 1989 R&D service Develops instruments and software for DNA and peptide synthesis. Develops cancer treatment drugs which target key molecular mechanisms associated with the cell cycle, chromatin control and DNA damage. Develops proteins with main focus on peptidases for use in downstream processing, peptide synthesis and drug discovery. Symphogen A/S, Elektrovej Building 375, 2800 Lyngby, Tel TAG Copenhagen A/S, Research Park Symbion, Fruebjergvej 3, 2100 Copenhagen O, Tel TopoTarget A/S, Fruebjergvej 3, 2100 København Ø, Tel Unizyme Laboratories A/S, Dr. Neergaardsvej 17, 2970 Hoersholm, Tel Valderm ApS 2003 R&D A development company focusing on pharmaceutical development of anthracyclines into topical formulations for treatment of hyperproliferative skin diseases. Valderm ApS, Lundtoftevej 277, 2800 Kgs. Lyngby, Tel: VersaMatrix A/S 2002 Develops a technology for the fast identification and development of affinity ligands. VersaMatrix A/S, Gamle Carlsberg Vej 10, 2500 Valby, Tel / not active Vipergen ApS 2005 R&D Develops a drug discovery technology platform providing access to small molecule combinatorial libraries of up to compounds. Vipergen ApS, Fruebjergvej 3, 2100 Copenhagen, Tel

15 ViroGates A/S 2000 R&D Focused on HIV research and disease prognostics. Zealand Pharma A/S 1998 R&D Develops peptide-based drugs that target diseases and symptoms. ViroGates A/S, Scion-DTU, Diplomvej 377, 2800 Lyngby, Tel Zealand Pharma A/S, Smedeland 26 B, 2600 Glostrup, Tel ZGene A/S 2001 R&D Zymenex A/S 1998 R&D 2CureX ApS 2006 R&D 7 TM Pharma A/S 2000 R&D Focused on improving existing cancer treatments. Develops a technology that enhances the effect of current anti-cancer drugs and reduces their toxicity. Develops innovative therapeutics for life threatening diseases such as lysosomal storage diseases. Develops drug candidates for the treatment of cancer with focus on colon and neuronal cancer. Develops novel drugs for 7TM receptor targets with therapeutic focus on metabolic disorders, including obesity, and inflammatory disorders, targeting allergic rhinitis and asthma. ZGene A/S, Agern Allé 7, 2970 Hoersholm, Tel Zymenex A/S, Roskildevej 12 C, 3400 Hillerød, Tel CureX ApS Birkevej 37, 3460 Birkerød Tel TM Pharma A/S, Fremtidsvej 3, 2970 Hoersholm, Tel