LIFE SCIENCES & HEALTH BRABANT, EUROPE S HEART OF SMART SOLUTIONS

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1 LIFE SCIENCES & HEALTH BRABANT, EUROPE S HEART OF SMART SOLUTIONS

2 Life Sciences in Brabant Biopharma, medtech and logistics / distribution are strongly connected Biopharma High density of hospitals possibilities for clinical trials. Close cooperation between industry, universities and government. Availability of highly educated, highly skilled labor force with close to native proficiency in English. STRONG BIOPHARMACEUTICAL SECTOR MSD, Aspen, Aduro Biotech, AstraZeneca, MSD Animal Health, Janssen-Cilag, Patheon, Bioconnection. Medtech Logistics STRONG MEDICAL TECHNOLOGY CLUSTER Philips Healthcare, Philips Research, GE Healthcare, High Tech Campus and surrounding supply chain partners. STRONG LIFE SCIENCES LOGISTICS SECTOR Abbott Logistics, Amgen Europe, Hollister, Novartis, Janssen- Cilag and specialized logistics service providers as Movianto, Rhenus Logistics and Healthlink.

3 Clusters in Brabant BioPharma R&D and Manufacturing BioPharma Logistics Oss High Tech Campus Breda Eindhoven: Eindhoven Oss: Oss Breda: 60 km 45 km 70 km Medical Technology R&D and Manufacturing

4 Pharma-industry in Brabant There are 446 life sciences companies located in Brabant, accounting for 11,000 jobs.* A larger number of companies is engaged in medical Technology. However, the majority of jobs are found within pharmacy. This means that there are a few relatively large pharmaceutical companies that account for many jobs, which is supported by the presence of MSD, Aspen, Janssen-Cilag, Amgen and MSD Animal Health. * Including companies < 5 jobs, excluding wholesale.

5 Pharmaceutical industry in Brabant

6 Key areas in Brabant ONCOLOGY IMMUNOLOGY DRUG DELIVERY MSD Biotech, Oss NTRC, Oss Medimetrics Drug Delivery, Eindhoven MSD Pharmaceutical, Oss ModiQuest, Oss Synnafix, Oss Aduro Biotech Europe, Oss LeadPharma, Oss Patheon, Tilburg ModiQuest, Oss Glycostem, Oss Medtronic, Eindhoven LeadPharma, Oss Glycostem, Oss Synnafix, Oss Atra Zeneca, Oss (previously AcertaPharma) NTRC, Oss Dolphys Medical, Eindhoven Elekta, Best Medtronic, Eindhoven Verbeeten Institute, Tilburg, Breda, Den Bosch AstraZeneca, Oss (previously AcertaPharma) LifeTec Group, Eindhoven

7 Pharma cluster in Oss Main players in Oss The life sciences cluster in Oss largely consists of three major players: MSD, Aspen and Pivot Park. These three players are located next to each other in the center of Oss. Together with some smaller companies, the region Oss accounts for 3,500 jobs in Life Sciences. Ecosystem There are more LSH companies in Oss, for a large part SMEs that distribute medical supplies or companies that develop medical or dental devices. Movianto, Fysicon and QRS Healthcare are examples of companies that strengthen the ecosystem.. This is a sample of the companies that together form a strong life sciences cluster in Oss.

8 Pivot Park An open innovation biopharmaceutical campus in Oss located on the premises of a large-scale MSD and Aspen site 38 companies with a total of 350 employees Co-development project of MSD & national and regional partners Facilitating open innovation Drug discovery R&D: from target to market

9 Pivot Park community Product development CROs CMOs Other services

10 Pivot Park: a unique combination FACILITIES, EQUIPMENT, KNOWLEDGE AND APPROACH Lab & Office facilities Analytics HTS uhts Compounds Pilot Plant Fully equipped labs Open Access labs Flex labs Nuclear Magnetic Resonance Liquid Chromatography Mass Spectrometry Open Access HTS Flexible uhts Hit / Lead optimization Up to 10 kg GMP standard Small molecules

11 Available equipment to tenants Ʃ EUR 23 mln To rent Pivot Park Service and flex space 3% Pivot Park has ~ 23 mln. worth of equipment that makes the Park even more attractive for new and existing companies WAYS EQUIPMENT CAN BE OFFERED TO TENANTS: To rent: equipment with commercial value over EUR 5,000 and salvage value of more than 10% 26% 48% Core facilities Starters package: equipment with commercial value less than EUR 5,000 or salvage value less than 10% plus individually selected equipment Core facilities: equipment linked to the core facilities HTS, kilolab, analytics. Pivot Park: equipment used for services, e,g. Cleaning facilities, cell line storage and H 2 and C-lab Starters package 23%

12 Pivot Park Screening Centre (PPSC) Pivot Park Screening Centre provides drug discovery services in the field of assay development, lab automation and (ultra) High Throughput Screening ((u)hts). ASPIRE system Flexible Open access facility for tenants HTS and Hit/Lead Optimization Efficient data processing uhts system State of the art Flexible & high capacity Acoustic dispensing technology Online storage

13 Pivot Park Screening Centre (PPSC) FULLY AUTOMATED SYSTEMS State-of-the-art (u)hts Efficient, flexible & versatile Acoustic dispensing technology Flexible size: HTS & uhts 250,000+ HIGH QUALITY DRUG-LIKE COMPOUNDS Selection based on 15+ years pharma experience Screening solutions Solids for follow-up DRUG DISCOVERY EXPERTISE Lab Automation Assay development Information technology

14 Your personal contact Yvonne Kemps Project Manager Life Sciences M E ykemps@bom.nl BRABANT DEVELOPMENT AGENCY TEAM FOREIGN INVESTMENTS Goirleseweg 15, 5026 PB Tilburg P.O. Box 3240, 5003 DE Tilburg The Netherlands T +31 (0) E info@foreigninvestments.eu I /company/bom-foreign-investments /bomforeigninvestments

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