CURRICULUM VITAE CAROLINA DALMASSO

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1 CURRICULUM VITAE CAROLINA DALMASSO Department of Physiology & Biophysics - Women's Health Research Center University of Mississippi Medical Center 2500 N. State St. Jackson, MS [email protected] RESEARCH EXPERIENCE My research interest was focused on understanding the physiological mechanisms by which gonadal steroids modulate the renin-angiotensin system, as well as the neuroendocrine basis of regulatory behaviors controlling body fluid homeostasis. A comprehensive understanding of these mechanisms in both females and males is fundamental to elucidate key pathophysiological aspects related to cardiovascular diseases such us hypertension, as well as gender differences in the regulation of several systems. My graduate work with Dr. Laura Vivas concerned the study of estrogenic modulation of body fluid homeostasis. In this work I demonstrated the involvement of the serotonergic system as a possible mechanism in the inhibitory action of estrogen on induced sodium intake in female rats. The hormonal status during the estrous cycle and estradiol replacement after ovariectomy changed the neural activity induced by sodium depletion in cells of specialized neural structures (i.e., circumventricular organs and serotonergic cells of the dorsal raphe nucleus). These changes correlated with the decrease in sodium intake observed during high estrogen concentration stages. In addition, I showed that estrogen influences the vasopressinergic neural activity and the associated diuresis after fluid depletion. Another key aspect of my work was a study of the estrogenic modulation of the brain renin-angiotensin system after fluid depletion. In this regard, I found an additional mechanism by which estrogen inhibits sodium appetite through a decreased activation of the central mechanisms of induction of thirst, triggered by the activation of renin-angiotensin system. I found that estrogen decreases the angiotensin AT 1 receptors in brain areas involved in fluid balance regulation. EDUCATION 2012 Ph.D. in Biological Sciences. Universidad Nacional de Córdoba, Argentina. Dissertation: Estrogenic modulation of hydromineral balance. Carolina Dalmasso 1

2 Advisor: Dr. Laura Vivas. Independent Research Scientist, National Research Council of Argentina, Head of Hydromineral Homeostasis Laboratory, Mercedes and Martín Ferreyra Institute of Medical Research; Assistant Professor of Animal Physiology, School of Biology, University of Córdoba Fellowship. Laboratory for Clinical Studies, Córdoba, Argentina. Advisor: Dr. Cristian Hansen M.Sc. in Biology. Universidad Nacional de Córdoba, Argentina. Dissertation: Effect of chronic stress on the Fos immunoreactivity and glucocorticoid receptor in the anterodorsal thalamic nucleus in early maternal deprivated rats. Advisor: Dr. Marta M. Suárez, Professor of Animal Physiology, School of Biology, University of Córdoba. Co-Advisor: Dr. Laura Vivas. POSITIONS AND TRAVEL AWARDS 2004 Research Fellow, National Agency of Scientific and Technological Promotion (ANPCyT) through the Scientific and Technological Research Fund (FONCyT) Doctoral Fellowship, National Research Council of Argentina (CONICET) Doctoral Fellowship, National Research Council of Argentina (CONICET) Fundación Interior Argentina (Funinar), INIMEC-CONICET-UNC SfN/IBRO International Travel Grant 2010 award to attend the 2010 Society for Neuroscience annual meeting, San Diego, CA, USA, November, 13-17, ISN Travel Award Third INF Summer School in Neuroendocrinology Brazil and First Brazilian International Symposium on Integrative Neuroendocrinology. August, 13-24, Instituto de Investigación Médica Mercedes y Martín Ferreyra Postdoctoral Fellow Department of Physiology & Biophysics - Women's Health Research Center - University of Mississippi Medical Center PEER-REVIEWED PUBLICATIONS Carolina Dalmasso 2

3 Dalmasso C, Amigone JL, Vivas L. Serotonergic system involvement in the inhibitory action of estrogen on induced sodium appetite in female rats. Physiol Behav Sep 1; 104(3): Rivarola MA, Dalmasso C, Valdez DJ, Vivas LM, Suárez MM. Early Maternal Separation and Chronic Variable Stress as Adults Differentially Affect Fos Expression in the Anterodorsal Thalami Nuclei. Int. J. Neurosci May; 118 (5): MANUSCRIPTS IN PREPARATION Macchione AF, Caeiro XE, Dalmasso C, Vivas L, Godino A. Sodium appetite: why does it not develop immediately after sodium depletion? Manuscript in preparation. Dalmasso C, Imboden H, Vivas L. Estrogenic modulation of angiotensin AT 1 receptors (AT 1 -R) in response to acute body sodium and water depletion: participation of estrogen receptor (ER- ). Manuscript in preparation. Dalmasso C, Boarato David R, Roncari C, Vivas L, Johnson AK, Menani JV and De Luca, Jr. LA. Water deprivation-induced sodium appetite: brain fos immunoreactivity and self-stimulation. Manuscript in preparation. BOOK CHAPTER Vivas L, Godino A, Dalmasso C, Caeiro X, Macchione F, Cambiasso MJ. Chapter X: Neurochemical circuits involved in fluid and cardiovascular regulation: role of serotonin, oxytocin and angiotensinergic systems in Neurobiology of Body Fluids Homeostasis: Transduction and Integration. Taylor & Francis Group, LLC. Eds DeLuca/ Johnson/ Menani. October WORK PRESENTATIONS 2003: Dalmasso C, Valdez DJ, Suárez MM. Effect of chronic stress on the Fos immunoreactivity and glucocorticoid receptor in the anterodorsal thalamic nucleus in early maternal deprivated rats. XLVIII scientific reunion of the Carolina Dalmasso 3

4 Argentine Society of Clinical Investigation (SAIC). Poster. Abstract publish in Medicina, vol. 63, 5/2, : Dalmasso C, De Luca, JR. L, Vivas L. Brain fos immunoreactivity pattern after fluid reestablishment in water deprived rats. Poster-Abstract SAN XX, Pinamar, Buenos Aires. December 3-6, : Dalmasso C, Vivas L. Effects of gonadal steroids on estrogen receptor alpha (ERα) density in the lamina terminales during hypovolemic thirst. Poster-Abstract ALACF 2006, Buenos Aires, Argentina. November 4-7, : Macchione, A.F., Dalmasso, C., Vivas, L. Sexual dimorphism in hypovolemic thirst induced by Furosemide and low sodium diet treatment (F/LSD). Poster- Abstract publish in Medicina Vol. 67. Supl. III. Buenos Aires, : Vivas L, Macchione AF, Dalmasso C. Sexual dimorphism in hypovolemic thirst induced by Furosemide and low sodium diet treatment (F/LSD). Poster-Abstract in Experimental Biology San Diego, California, USA. Abstract publish in The FASEB Journal 2008; 22: Dalmasso C, Vivas L. Estrogenic modulation of hydroelectrolitic balance. LIII annual reunion of the SAIC, annual reunion of SAFIS. Poster-Abstract publish in Medicina Vol. 68, Supl. II. Mar del Plata, Buenos Aires. November 19-22, : Dalmasso C, Ponce L, Vivas L. Estrogenic modulation of angiotensin AT1 receptors (AT1-R) in response to furosemide depletion. Poster-Abstract in the Argentine Congress of Physiology of the Argentine Society of Physiology. October 15-16, La Plata, Argentina, : Dalmasso C, Ponce L, Vivas L. Estrogenic modulation of angiotensin AT1 receptors (AT1-R) in response to acute body sodium and water depletion. Presented in: - Neuroscience Meeting of the Society for Neuroscience (SFN). November, San Diego, USA. - First Brazilian International Symposium on Integrative Neuroendocrinology. Dourado, Brasil. August 20-23, : Macchione A; Dadam F.; Dalmasso C.; Vivas L. Dimorfic expression of fluid intake patterns and vasopressin system activity. INIMEC-CONICET-UNC. Poster- Abstract publish in Medicina Vol. 73, Supl. III. Mar del Plata, Buenos Aires Carolina Dalmasso 4

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