PackAge 2011 CONFERENCE A PRESENTATION ON. Barrier Packaging gof Pharmaceuticals

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1 PackAge 2011 CONFERENCE A PRESENTATION ON Barrier Packaging gof Pharmaceuticals Focus BLISTER PACKAGING

2 Benefits of a Blister Packs Convenient, easy to use and safe Increases compliance and adherence Easy to dispense Product protection Cost effective Child resistant / Senior friendly Improved Pharmacy efficiency Alleviates space and inventory concerns

3 Other Benefits Marketing Differentiation Compact clear blisters ensures product visibility Additional Branding on packs Pack Innovation e.g Burgo pack.shell Pack,Calender pack Shell pack Burgo pack Calender pack

4 World Pharmaceutical Packaging Demand World Pharma Blister Packaging demand

5 Blister Packaging Film Types Thermoforming Films PVC PVC/PVdC PVC / Aclar APET, PET G PP/COC/PP Barex Cold Forming Films OPA/ALU/PVC OPA / ALU/HSL ( tropical Blister)

6 Blister Packaging Classification- Barrier Low Barrier PVC APET, PET G PP Medium Barrier PVC/PVdC COC High & Ultra High Barrier PVC / Aclar Cold Forming Foils

7 Blister Packaging Classification-Type Halogen Free Films PP Barex ( PAN) PP/COC/PP APET, PET G, GAG PET New Generation Films New Generation Films Ultra High Barrier PVdC (Ultrsafe) Galaxy (New Innovation by ACG) Alukbliss ( Innovation by ACG)

8 PVC Mono Layer Films PVC Poly Vinyl Chloride Low Barrier Films suitable for stable molecules Cost effective blister packaging option Amorphous in nature WVTR 3.5 g/m²/day Calendered films available in range of colours Long shelf life.

9 PVdC Coated PVC PVC/PVdC Moderate Oxygen Barrier. Range of barrier is available from g/m²/day depend on gsm of coating. PVC/PVdC/PVC Cross migration is low. No conveyer sticking. No abrasion to PVdC coating.

10 PVC /PE /PVdC Tripac Films PVC / PE / PVdC - Tripac Moderate Moisture Barrier The PE layer improves Blister formation Higher post forming barrier due to uniform thickness on cavity

11 UltraSafe - Ultra High Barrier New Generation PVdC Barrier Films Ultra High Barrier properties Available in 120 gsm Suitable for Rotary and Flat Bed Blister Machines

12 Aclar - The Ultimate Barrier Excellent barrier properties against water vapor Ideal for hygroscopic products Improves strength and formation of blister Various PVC thickness and Aclar grades give flexibility and desired WVTR characteristic

13 PVC / Aclar - Laminates Crystal clear packing Chemically and bio-chemically inert Extended Shelf Life Design and Marketing Flexibility Transparent to UV radiation Non ageing For High and Ultra-High moisture Barrier

14 Aclar Range Aclar Variant Thickness in WVTR Micron g/m²/day (PVC/Aclar) Rx µm Rx 20 e SupRx µm µm 0.23 UltRx µm 0.15 UltRx µm 0.07 UltRx µm 0.05 UltRx µm Under development

15 Pet G / Aclar PVC Free film Good Clarity Aclar Variants Aclar / EVOH / Aclar Oxygen and Moisture barrier PVC / Aclar / PVC lower cross migration Lay flat blisters Lower abrasion to Aclar.

16 COLD FORM BASE FOILS Structure OPA 25µ/Alu45µ/PVC60µ Ultra high barrier properties Suitable for all climatic zones Excellent delamination resistance DMF approved material

17 Cold-formable Tropical Blister It can withstand to low and high temperatures es Typical lacquer sealing to: PVC, PVdC,PP High barrier to light, moisture, oxygen and other gases

18 Non Halogenated films (NON PVC OPTIONS)

19 Barex Gas Barrier Films Composite of Barex & Polypropylene Excellent Gas Barrier from Oxygen, Nitrogen, & Carbon Dioxideid Retains Aroma High Impact Strength High resistance to solvents & aggressive hard to hold liquids Thermoformable on conventional blister packing machines OTR is Deg.C. & 100% RH

20 Barex Features High impactstrength Retains aroma High resistant to solvents & aggressive hard to hold liquids. Excellent gas barrier from Oxygen, Nitrogen and Carbon dioxide. Properties (Barex 250μ) Density: 1 15g/cm³ Density: 1.15g/cm MVTR(38⁰C,90%RH):3.5g/m²/day OTR(23 ⁰C.100%RH):1.55cc/m²/day

21 PP/COC/PP High clarity Density is 1.00 gm/cm3 hence higher yield Thermoforming range is 120 to 160 Deg.C. WVTR is 0.2 to 0.4 Deg.C. & 90 % RH

22 Polypropylene Thermoformable FDA Compliant Low density (0.9 gm/cm3) hence high yield WVTR Deg.C. & 90 % RH OTR is 320 Deg.C. & 100 % RH

23 PETG films Excellent thermoformability High gloss & superb clarity, Sterlisable (Ethylene Oxide / Gamma radiation) Excellent printability MVTR is 14 to 16 gm/m2/day PETG/ Aclar laminate provides excellent barrier Made under license at Eastman Chemicals

24 APET based Films Eco-friendly material Thermoforming range 121 o C to 154 o C MVTR 5.0 g /m 2 / day at 38 o C, 90% RH OTR 10.0 cc/m 2 / day at 23 o C, 0% RH Well suited for Filling & Sealing machines. Excellent printability High clarity

25 Beyond Blister Packing Unit Dose & Suppository Packing

26 PVC / PE SUPPOS PVC/PE SUPPOS are PVC / PE Laminates that are unique Peelable/Sealable composites Uniquely sealable and peelable on any form Fill seal line Complete range of 100/30 to 300/ 50 PVC / PE available Proprietary PE allows effective sealing and easy peel For moisture sensitive suppository PVdC coated SUPPOS film also available ( Typically 40 gsm) Available in Printed Random Printed Register printed Distortion Printed

27 Your trusted partner for Barrier Packaging Solutions

28 Overview ACG Pharmapack A leading innovation-driven and world-class manufacturer of all pharmaceutical barrier films One-stop shop for all Pharma Barrier Packaging films. DMF Registered with the US FDA. Registered with SFDA (China) & Canada Health Dept. Exporter to more than 65 countries Integrated Facility ensuring traceability ISO 9002 / / certified

29 Thank You

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