BIOVIA: SCIENTIFIC INNOVATION IN THE AGE OF EXPERIENCE A NEW SCIENTIFIC COLLABORATIVE ENVIRONMENT

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1 BIOVIA: SCIENTIFIC INNOVATION IN THE AGE OF EXPERIENCE A NEW SCIENTIFIC COLLABORATIVE ENVIRONMENT

2 A NOTE FROM MAX BIOVIA CEO Industries needing science to create products and advance innovation require expert knowledge to simplify their complex processes. BIOVIA uniquely invests in and delivers informatics and technology solutions supporting scientific innovation lifecycle processes and intelligence. BIOVIA will provide the solutions needed by our customers to model the Biosphere and MaterialSphere, based on the vision of Dassault Systèmes to give business and people the 3DEXPERIENCE to imagine sustainable innovations capable of harmonizing Product, Nature and Life. We focus on science and process based industries including pharmaceutical and biotechnology; chemicals; consumer packaged goods; food and beverage; energy, semiconductor and electronics; transportation including automobile and aerospace; as well as academic and government. Now more than ever, enterprise customers are demanding a strategic partner that shares their vision and passion in today s changing business and scientific environment. I invite you to learn more about how your colleagues are accelerating innovation, improving productivity and reducing costs with BIOVIA s modeling and simulation; laboratory and quality management; and process intelligence capabilities. Our experienced scientists and industry experts are dedicated to making customers successful in a world of new possibilities. Working together, we can make the difference in changing industry and leveraging science to create a healthier, safer and more productive world. Max Carnecchia BIOVIA CEO

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4 We focus on science and process based industries including pharmaceutical and biotechnology; chemicals; consumer packaged goods; food and beverage; energy, semiconductor and electronics; transportation including automobile and aerospace

5 BIOVIA: VALUE FOR SCIENCE-DRIVEN COMPANIES Science-based companies create a wide variety of products, from airplanes built out of composite materials to biopharmaceutical therapeutics to consumer packaged goods. These diverse industries are similar in one respect though. They all have science in their recipes and innovation at their core. The BIOVIA brand of Dassault Systèmes drives collaboration with science-based experiences supporting modeling and simulation, research and open collaborative discovery, enterprise laboratory and quality management systems and process management intelligence all build on Dassault Systèmes 3DEXPERIENCE platform. The 3DEXPERIENCE platform bridges data, information, ideas, people, virtual worlds and solutions, making it possible to design, test and evaluate final customer experiences that are rich in meaning, emotion and value. Industry solution experiences from BIOVIA are already helping enterprise customers model, simulate, manage and better understand how their products can interact in harmony with nature and life. Our customers include Fortune 500 companies such as AstraZeneca, BASF, Bristol-Myers Squibb, Du Pont, GlaxoSmithKline, L Oreal, Procter & Gamble, Pfizer, Sanofi, Shell and Unilever. Sustainable value creation is a real and relevant mission dedicated to improving society, technology and life. It is a big goal, but a relevant one that motivates BIOVIA employees to act as catalysts for innovation. We are committed to helping organizations better leverage science to harmonize Product, Nature and Life. The Organizations We Serve Pharmaceutical and Biotechnology Chemicals Consumer Packaged Goods Food and Beverage Energy, Semiconductor and Electronics Transportation including Automobile and Aerospace Academic and Government

6 BIOVIA: SCIENTIFIC EXPERIENCES FOR THE BIOSPHERE AND MATERIALSPHERE BIOVIA helps customers model the BioSphere and the MaterialSphere to drive better and faster innovation, reduce costs and improve quality. Scientific Product Lifecycle Management automates critical processes, integrates information and advances internal and worldwide collaboration from early discovery to commercialization. To help customers accelerate innovation, speed time-to-market and improve competitiveness, we deliver proven solution experiences supporting nine key scientific activities: Chemical and Biological Modeling and Simulation: Predictive science solutions for small molecules and biotherapeutics-based drug design enable life scientists to investigate and test hypotheses in-silico prior to costly experimentation. Materials Modeling and Simulation: Solutions for nanotechnology, catalysis, polymers and pharmaceutical development allow materials scientists to engineer better performing materials of all types. Systems Biology and Integrative Therapeutics: Through global scientific collaboration, content federation, semantic search, virtual modeling and predictive simulations, pharmaceutical researchers can improve the success rate of delivering new, better targeted therapies. Open Collaborative Discovery: Proven solutions from technology transfer through networked collaboration to scientific informatics increase flexibility, reduce complexity and improve operational excellence. Enterprise Laboratory Management: Process management and compliance applications from Electronic Laboratory Notebooks to Laboratory Information Management Systems and mobile data capture apps accelerate product development and time to innovation. Process Manufacturing Intelligence: Robust product and process monitoring solutions with routine process trending and monitoring-by-exception can decrease production costs and delays by reducing process variability. Enterprise Quality Management: Mission-critical, end-to-end content and process compliance solutions for highly regulated industries reduce regulatory risks, lower quality costs, improve compliance effectiveness and increase operational efficiency. Scientific Pipelining: The industry-leading Pipeline Pilot scientific authoring application allows scientists to rapidly create, test and publish scientific services that automate the process of accessing, analyzing and reporting data. Bioactivity and Chemical Sourcing Content: Comprehensive databases deliver unique answers to chemical sourcing and bioactivity questions, saving time, reducing costs and enhancing decision confidence.

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8 LEADERS IN SCIENTIFIC INNOVATION ARE ADDRESSING CHALLENGES IN THEIR MARKETS Innovating Faster Long R&D cycles faced by Pharmaceutical and Biotechnology companies tend to inhibit rapid product development. Consumer packaged goods and electronic companies require the agility to continuously bring new products to market to retain consumer interest and maintain competitive advantage. Competing More Effectively Competition drives faster innovation to provide customers with new, better and more attractive products, or more cost-effective products. Getting to market first with the right, quality product is demanding. Addressing Price Pressures Companies delivering differentiated products to emerging markets at affordable price points must reduce costs to remain profitable. Organizations need to be innovative, constantly delivering quality products at lower costs. Producing Environmentally Safe and Sustainable Products The need to incorporate more expensive raw materials, reduce environmental impacts or produce more sustainable products can increase manufacturing costs. Protecting nature through safer, more sustainable products and processes enhances life. Operating Globally Supporting global growth and demand requires that companies expand knowledge sharing globally, and expand research and development locally while lowering the cost of production. Protecting Intellectual Property Managing intellectual property is emerging as a key activity impacting information access and collaboration. Innovative growing companies need to share the right information with the right people at the right time. Intellectual property protection comes with additional costs but, when combined with proper knowledge management, it supports better, faster innovation. Meeting Regulatory Requirements Regulatory compliance changes constantly and scrutiny is increasing. Companies need to feel confident that the systems they rely on for their enterprise solutions are capable of meeting regulatory and compliance requirements. To address these challenges and remain competitive, organizations need to deploy crossfunctional business processes that span the lifecycle of the product. Most importantly, they need to drive innovation, reduce costs and improve quality.

9 ADDRESSING THE CHALLENGES WE FACE Profound and far reaching challenges are impacting the science-based industries served by BIOVIA. Pharmaceutical and Biotechnology companies confront increasing cost pressures, expiring patents and declining R&D productivity as already long product development cycles are further extended by sub-optimal processes. Consumer Packaged Goods, Food and Beverage, Chemical, Electronics, Manufacturing, Automotive and Aerospace companies must contend with frequent changes in the availability of raw materials, the need for improved process efficiencies to maintain price points and complexities arising from combined chemical and biological processes. Trends impacting all the industries we serve include rapidly growing global markets with distinct local needs and preferences; increasingly complex and interconnected value chains that stretch the resources of process manufactures, and the rise of mobile cloud collaboration, social tools and improved analytics. One thing never changes the need to globally and sustainably deliver high quality products that comply with increasingly complex regulations.

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11 MEETING BUSINESS OBJECTIVES BIOVIA provides a scientific collaborative environment supporting advanced biological, chemical and materials experiences. Leading companies around the world recognize innovation improvements in these technology solutions from BIOVIA. Unlocking the Information that Drives Innovation Organizations need to know what they have done in the past to avoid repeating errors and build on success. With BIOVIA, customers can leverage research from previous experiments and avoid repeating thousands of tests and procedures. BIOVIA solutions enable scientists to search, access, reuse and trace critical information and data across multiple sites and globally dispersed organizations. Investing in Predictive Science From the design of new materials for the aerospace industry to the application of personal health care in the pharmaceutical industry, predictive science is a key enabler within design and decision making processes. Using BIOVIA to prequalify candidates in silico saves time and money while increasing hit rates and options for commercialization, reducing process cycle times and improving resource utilization for both life and materials scientists. Enabling Technology Transfer Science-based organizations need to leverage experimental and operational data generated along the product lifecycle. Quality and pilot plant data collected during late-stage commercialization in BIOVIA can accelerate early product, process and analytical method development by enabling better Quality by Design (QbD) experiments based on real-world conditions, experience and insight. Leveraging New Technologies Secure cloud solutions, new mobile applications, social networking and Big Data capabilities are lowering costs, improving performance, enhancing collaboration and helping turn data into insight from discovery to commercialization. In the Internet of Things, augmented reality and wearable devices like Google Glass are just a few of the possibilities for obtaining timely information through embedded intelligence. BIOVIA provides the technology infrastructure to support virtual workspaces in the cloud, along with mobile applications that leverage social collaboration for accessing and sharing information. We disrupt business as usual, creating opportunities for organizations to innovate faster and better. Ensuring Operational Excellence Many organizations today are redesigning their organizational culture to improve process efficiency and reduce costs. They are instituting approaches like Lean Manufacturing and Six Sigma to lessen process and product variability, reduce manual steps and errors and improve quality. In many cases, these improvements must also extend to external collaborators and joint venture partners whose activities are becoming increasingly integrated with those of sponsor organizations. Harmonizing and Standardizing Processes and Interoperability. Working with numerous disparate applications from different vendors can be costly and burdensome for IT organizations with few resources. To keep total costs low, BIOVIA technology is built on an open architecture that integrates with other systems, processes and solutions. This open architecture and the breadth of applications we offer across the entire product development lifecycle allows organizations to standardize on fewer vendors by working with BIOVIA. Collaborating Globally. Innovation is a collaborative effort involving internal and external teams. Virtual teams using BIOVIA can stay in touch, communicating the right information at the right time quickly and securely externally and internally. Protecting Critical Intellectual Property The true value of an organization resides not in the products it produces but in the intellectual property underpinning the products. With BIOVIA, organizations can protect their valuable Intellectual Property across the entire product lifecycle from discovery to commercialization. Meeting Regulatory Requirements The US Food and Drug Administration, the US Environmental Protection Agency and the European Union s REACH chemical substances regulation are driving compliance initiatives today. When processes fail, financially painful and brand-damaging product recalls result. Regulated organizations and those working in Good Manufacturing Practice environments are increasingly turning to BIOVIA solutions for defect tracking, process compliance reporting, quality by design and continuous process verification to improve productivity and reduce compliance deviations.

12 BIOVIA: SCIENTIFIC PRODUCT LIFECYCLE MANAGEMENT BIOVIA s sophisticated enterprise capabilities in modeling, simulation, laboratory and quality management are integral to discover, design, deploy and deliver new products in many of the world s leading science-based research organizations. Why? These market-leading companies need a robust, proven process informatics framework to support innovation, reduce costs and improve quality. BIOVIA s Scientific Product Lifecycle Management approach integrates research and development information across the enterprise. The system delivers technology infrastructure that automates critical processes and enables scientists to capture, access and harmonize core information and data from discovery to commercialization. BIOVIA s industry communities struggle with cumbersome data management and analysis processes and limited access to existing knowledge and real-time reporting. In response, the aggressive industrialization of research, development and manufacturing processes is driving the adoption of an integrated digital backbone of diverse information types, and this is where BIOVIA s foundational technology framework shines.

13 GLOBAL COLLABORATION FOR SCIENCE BIOVIA is a scientifically aware, open, enterprise collaborative framework that integrates critical lab-enabling software with existing information sources and enterprise systems. BIOVIA helps organizations to deploy scientific software and services along the end-to-end product and process lifecycle. The BIOVIA processes cover modeling, simulation, laboratory and quality management and provide access to internal and external data sources. BIOVIA s Scientific Innovation Lifecycle Management approach and foundational technology accelerates products from discovery to commercialization, making it easier for organizations to manage and connect scientific innovation processes and information with other lifecycle systems. These BIOVIA capabilities reduce overall cycle times, enable predictive insights, provide access to internal and external scientific information, improve sustainability and enhance quality and compliance. Foundational Services manage scientific data, store and run algorithms and methods and manage resources. Applications built on or integrated with the BIOVIA Foundation support scientific processes with customers operating as strategic partners for applications in specific domains. The common Experience helps scientists to consistently access and visualize data, tasks and applications supporting innovation, collaboration and process efficiency. Our open architecture and the breadth of applications we offer across the entire product development lifecycle means fewer vendors to manage and many more strategic opportunities to explore with a dedicated scientific partner.

14 LEADING COMPANIES CHOOSE BIOVIA Working with more than 2,000 customers, BIOVIA is turning industry challenges into opportunities through Scientific Innovation Lifecycle Management deployments. Scientific Innovation Lifecycle Management solutions are critical to digitizing processes that can accelerate innovation, increase return on investment, ensure compliance and transform industries. We share your vision and passion for what is possible in today s changing environment. Many leading organizations are choosing BIOVIA for innovating and managing the lifecycle. 10 of the top 10 pharmaceutical companies 20 of the top 25 biotech companies 7 of the top 10 chemical companies 4 of the top 5 consumer packaged goods companies 5 of the top 10 oil and gas companies 5 of the top 5 aerospace Numerous academic and government organizations

15 WHAT DOES BIOVIA OFFER? What does BIOVIA offer? BIOVIA helps customers of science-based industries meet the challenges of today s world. We ask the right questions and provide remarkable experiences to drive scientific innovation. We help customers innovate better, faster and more cost effectively and bring higher quality compliant products to market faster. At the same time, we support customers in protecting, managing and leveraging their most valuable asset: Their Intellectual Property. Whom do we serve? BIOVIA solutions create an unmatched collaborative environment that can help science-and process-driven companies create and connect biological, chemical, and material innovations to improve the way we live. BIOVIA is committed to enhancing and speeding innovation, improving productivity and compliance, reducing costs, and accelerating product development from discovery to commercialization for sciencedriven enterprises of all industries. What can customers expect? As a brand of Dassault Systèmes, BIOVIA offers industry solution experiences based on our proven Scientific Product Lifecycle Management approach and built on the scientifically aware BIOVIA Foundation. We have combined the Scientific Product Lifecycle Management vision and foundational technology with the Dassault Systèmes 3DEXPERIENCE platform to create value-based industry experiences that leverage scientific innovation for a healthier, safer and better world.

16 BIOVIA: DELIVERING NEXT-GENERATION INNOVATION TODAY BIOVIA is today s open enterprise collaborative environment for integrating software applications and services into industry solution experiences that transform the world of scientific innovation. The BIOVIA 3D experiences bring the scientific innovation lifecycle to a new level by: Managing and connecting scientific innovation processes and information through an open lifecycle framework Enhancing time to value through predictive insight driven by comprehensive and deep functionality in modeling and simulation Reducing cycle times while improving sustainability through quality and compliance Improving velocity across the discovery to commercialization process BIOVIA: Science-driven Worldwide BIOVIA is uniquely science-driven. Staffed with more than 225 Ph.D.s we have the experience and knowledge to design, develop, deploy and deliver successful enterprise-class solutions and experiences that can improve the productivity of science-driven innovators and accelerate new products to market. More than 20% of our company revenue feeds organic R&D. We provide our customers with experiences that support science-based industries and accelerate new product commercialization Our industry solutions are designed to be open, to integrate and interoperate with scientific and business solutions of Dassault Systèmes as well as with those of other recognized industry solution providers, and with data stores deployed by enterprises. Our global footprint provides support, consulting and training capabilities around the world. Our advanced Management Consulting strategies transform research, development and manufacturing workflows into innovative integrated processes. This combination allows BIOVIA to deliver 3D experiences that transform the world of scientific innovation.

17 BIOVIA: SUCCESS IN RESULTS 30% reduction in errors and reworks 35% reduction in review times 40% reduction in audit and report time 90% reduction in regulatory reporting (APR) cycle times 10x reduction in batch deviation risk 50% decrease in cycle times 25% improvement in productivity 25% improvement in accuracy 25% improvement in quality 25% improvement in regulatory compliance

18 Our 3DEXPERIENCE Platform powers our brand applications, serving 12 industries, and provides a rich portfolio of industry solution experiences. Dassault Systèmes, the 3DEXPERIENCE Company, provides business and people with virtual universes to imagine sustainable innovations. Its world-leading solutions transform the way products are designed, produced, and supported. Dassault Systèmes collaborative solutions foster social innovation, expanding possibilities for the virtual world to improve the real world. The group brings value to over 170,000 customers of all sizes in all industries in more than 140 countries. For more information, visit Dassault Systèmes Corporate Dassault Systèmes 175 Wyman Street Waltham, Massachusetts USA BIOVIA Corporate Americas BIOVIA 5005 Wateridge Vista Drive, San Diego, CA USA BIOVIA Corporate Europe BIOVIA 334 Cambridge Science Park, Cambridge CB4 0WN England 2014 Dassault Systèmes. All rights reserved. 3DEXPERIENCE, the Compass icon and the 3DS logo, CATIA, SOLIDWORKS, ENOVIA, DELMIA, SIMULIA, GEOVIA, EXALEAD, 3D VIA, BIOVIA, NETVIBES, and 3DXCITE are commercial trademarks or registered trademarks of Dassault Systèmes or its subsidiaries in the U.S. and/or other countries. All other trademarks are owned by their respective owners. Use of any Dassault Systèmes or its subsidiaries trademarks is subject to their express written approval.