Adaptive Optics Phoropters

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1 Adaptive Optics Phoropters Scot S. Olivier Adaptive Optics Group Leader Physics and Advanced Technologies Lawrence Livermore National Laboratory Associate Director NSF Center for Adaptive Optics

2 Adaptive optics are a key enabling technology for LLNL projects in laser beam control and imaging Wavefront control capabilities are crucial for many LLNL projects involving high power lasers LLNL-built sodiumlayer laser guide star AO system at Lick Observatory is world s first LLNL-built AO system at Keck Observatory is world s most powerful NIF requires AO on all 192 beams Enables accurate focusing of light into the target chamber for nuclear physics experiments

3 Headquarters at UC Santa Cruz 11 university nodes 3 primarily vision science (Rochester, Houston, Indiana) Over 25 partner institutions (research, education, gov., industry) Combines research and development in three science and technology areas: ASTRONOMY Visual acuity and retinal imaging degraded by aberrations in cornea and lens Without AO With AO ADVANCED TECHNOLOGY Without AO With AO Images of single cells in the living human retina Effect of AO aberration correction on the image quality of the 20/20 E VISION SCIENCE

4 Adaptive optics can provide unique diagnostic capability to study effects of vision correction Visual acuity is degraded by aberrations in the cornea and lens. wavefront corrector Adaptive optics correct for these aberrations. Without AO With AO Effect of AO aberration correction on the image quality of the 20/20 E. An adaptive optics system can be used to sense and correct aberrations in a subject s eye and allow detailed studies of visual performance under a variety of conditions.

5 Center for Adaptive Optics Vision Science Theme Development of compact clinical ophthalmic instrumentation Adaptive optics can be incorporated into fundus cameras to provide ophthalmologists with high-resolution retinal imaging for diagnostic and surgical applications. Conventional Phoropter Conventional Fundus Camera and image Adaptive optics can be used to replace the phoropter in order to allow optometrists to assess high-order aberrations in the eye while the patient directly observes the visual benefit of correction. Permanent correction of high-order aberrations would then be accomplished with custom laser eye surgery or contact lenses.

6 University of Rochester, Center for Visual Science Adaptive optics for vision science has been developed and demonstrated at the University of Rochester Laser diode λ = 790 nm Hot mirror Deformable mirror Control Computer Hartmann-Shack wavefront sensor CCD Lens array

7 Current adaptive optics systems for vision science are large, expensive laboratory instruments University of Rochester vision science adaptive optics system Conventional deformable mirror technology, which is both large and expensive, results in a large overall system due to the required magnification of the pupil of the eye to the size of the mirror Development of viable clinical ophthalmic adaptive optics instrumentation requires new enabling wavefront corrector technologies that are: compact, robust and inexpensive.

8 New adaptive optics to compensate for aberrations in the human eye could revolutionize ophthalmology Visual acuity is degraded by aberrations in the cornea and lens. wavefront corrector Without AO With AO Without AO Adaptive optics correct for these aberrations. With AO Effect of AO aberration correction on the image quality of the 20/20 E LLNL is leading a national effort to use new adaptive optics technologies to develop prototype high-resolution clinical ophthalmic imaging systems. Images of single cells in the living human retina MEMS deformable mirror liquid crystal spatial light modulator These systems will aid in the diagnosis and treatment of diseases causing blindness and the development of new techniques for vision correction in the general population Partners include Sandia National Lab, U Rochester, USC, UC Davis, UC Berkeley, US Army Aeromedical Research Lab, Bausch & Lomb, and Wavefront Sciences

9 High-resolution liquid crystal spatial light modulator is commercially available from Hamamatsu Advantages Compact 2 cm clear aperture Low cost > $30k Ease of use driven as a display High resolution correction (480x480) 200 times higher than largest DM

10 Acknowledgement: Project Team LLNL Scot Olivier AO Group leader Instrument Development Charles Thompson Electronics Engineer, project leader Scott Wilks Physicist, project scientist Robert Sawvel LEOT, optics, mechanics Dennis Silva EE TA, software, electronics Brian Bauman Optical Engineer, optical design Instrument Integration, Test and Deployment Don Gavel Electronics Engineer, project leader Abdul Awwal Optical Scientist, project scientist Robert Sawvel LEOT, optics, mechanics Dennis Silva EE TA, software, electronics Brian Bauman Optical Engineer, optical I&T UC Davis Prof. John Werner - Senior Ophthalmology Professor Thomas Barnes - Senior Optometrist Joe Hardy post-graduate researcher University of Rochester Prof. David Williams - Director, Center for Visual Sciences Nathan Doble post-graduate researcher

11 Adaptive optics phoropter using liquid crystal spatial light modulator Developed at LLNL for use at the UC Davis Medical Center Adaptive Phoropter: : correcting high-order aberration using Adaptive Optics Determine ultimate limits of visual acuity Relationship between normal aging, retinal disease and visual performance through psycho-physical physical testing

12 Complete view of adaptive optics phoropter at UC Davis using liquid crystal spatial light modulator Hartmann sensor Display for psychophysical testing SLM

13 Closed Loop: External aberration 1 st iteration rms Error in microns Gain = 0.2 iterations Convergence of the.25 D lens to 0.05 microns 9 th iteration

14 Human Eye Data Wavefront Sensor Image Reconstructed wavefront

15 Human Eye Wavefront Data Laser diode Super luminescent diode Measurement accuracy: 163 nm Measurement accuracy: 95 nm

16 New optical MEMS technology could lead to a revolution in adaptive optics Current adaptive optics systems are large and expensive due to available wavefront corrector technology The standard wavefront corrector is a deformable mirror consisting of a thin glass plate with a set of ceramic actuators glued to the back Typical conventional deformable mirror costs are $1,000 per actuator Small low-cost deformable mirrors can now be fabricated with MEMS techniques for ~$1 per actuator

17 Boston University Continuous MEMS SLM Fabrication: Silicon micromachining (structural silicon and sacrificial oxide) Electrostatically actuated diaphragm Attachment post Membrane mirror Actuation: Electrostatic parallel plates, individual addressing of identical actuators in an array Continuous mirror Configuration: 140 actuators (12 x 12 w/o corners), square grid, 300 µm spacing Surface Quality: 50 (30) nm rms Mirror surface map

18 University of Rochester, Center for Visual Science The Rochester AO Testbed MEMS LC-SLM

19 University of Rochester, Center for Visual Science The Mirror and Driver Boards Zygo Interferogram Photo: Paul Bierden, BMC

20 New MEMS deformable mirrors will have improved characteristics CfAO goal of 10 micron motion Electrostatically actuated Attachment diaphragm post Continuous mirror Membrane mirror Increased gap size will increase range of motion to 4-8 microns Self assembly technique allows large gap sizes 6 micron motion demonstrated designs for microns Low-stress membrane allows larger gaps for a given voltage 4 micron motion demonstrated designs for 10 microns mirror Incorporation of MEMS deformable mirrors with drive electronics will significantly reduce size and cost, improve functionality electrostatic actuator drive electronics

21 Acknowledgement: Project Team Scot Olivier : Principle Investigator Brian Bauman : Optics / Technical Lead Stephen Eisenbies : Mechanical Kevin O Brien : Business Collaboration Jack Tucker : Tech / Optics Steve Jones : Software / Project Lead Don Gavel : Technical Support Abdul Awwal : Tech. Input, LC SLM comparison Partners include Sandia National Lab, U Rochester USC, UC Davis, UC Berkeley, US Army Aeromedical Research Lab, Bausch & Lomb, Wavefront Sciences

22 Early design concept for clinical adaptive optics phoropter and using a MEMS deformable mirror Patient Adaptive Optics Module Wavefront Sciences COAS

23 Model of adaptive optics phoropter

24 Model of assembled prototype clinical adaptive optics phoropter on movable cart for portability

25 Complete assembled prototype clinical high-resolution ophthalmic imaging system using MEMS adaptive optics

26 Initial test data shows correction of 0.25 diopter lens to 0.01 diopter - still has some residual astigmatism

27 Conclusions The High-resolution Ophthalmic Imaging Systems project, sponsored by the DOE Biomedical Engineering Program, has made excellent progress in producing a prototype clinical adaptive phoropter using new MEMS wavefront corrector technology. The first generation of functional prototype adaptive phoropter instrumentation using MEMS deformable mirror technology will be available for clinical testing later this year. This new instrumentation will provide the ophthalmic community with another tool to facilitate progress on optimization of vision correction procedures. Tests of this new instrumentation will be facilitated by comparison with two laboratory adaptive optics systems for vision science at the University of Rochester (using a conventional deformable mirror) and UC Davis (using an LC SLM). Interested industry partners encouraged to attend CfAO Spring Industrial Advisory Board Session, March 21 in San Jose, CA