Medical Imaging Markets

Transcription

1 Medical Imaging Markets Phone: Fax:

2 Medical Imaging Markets Date: June 1, 2013 Pages: 455 Price: US$ 2, ID: M FFEN The purpose of this TriMark Publications report is to describe the specific market segment of the diagnostics market sector called medical imaging. Medical imaging can be categorized into nine main modalities: X-ray, ultrasound, computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT), magnetic resonance imaging (MRI), nuclear medicine (NM), mammography and fluoroscopy. Globally, X-ray is the most frequently used imaging procedure with about 108 million X-ray exams per year. MRI is second with 26 million examinations per year. PET, SPECT, CT and nuclear medicine rank third with 30 million examinations per year. Picture archiving and communication systems (PACS) and contrast agents are the sub-segments in medical imaging market that have gained significant growth in recent years. As a result of these medical imaging advancements, the multi-slice systems are generating large volumes of data, and this creates demand for data storage, 3-D visualization and analysis. As such, the global medical imaging industry is primed to experience significant growth through the next decade. This report surveys almost all of the companies known to be marketing, manufacturing or developing medical imaging equipment and supplies in the world. Each company is discussed in extensive depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the company's market position. Detailed tables and charts with sales forecasts and marketshare data are also included. Table of Content 1. INTRODUCTION 1.1 Statement of Report 1.2 About this Report Scope of the Report Objectives Methodology 1.3 Executive Summary 2. SYRINGE TYPES: AN OVERVIEW 2.1 Disposable Syringes 2.2 Safety Syringes Available Safety Syringe Technologies Retrofitted Syringes Automatically Retractable Syringes Manually Retractable Syringes Insulin Syringes Tuberculin Syringes Prefilled Syringes Components of a Prefilled Syringe Benefits of Prefills Prefills: The Future of Drug Delivery Wider Applications of Prefilled Syringes Making Improvements in Components of Prefilled Syringes Medical Imaging Markets 2

3 Biologic Drugs and Overfill Benefits of Cyclic Olefin Polymers Overcoming Variability in Glass Syringes Impact of Silicone Oil on Delivery Migrating Risk for Protein Aggregation Key Advantages of Prefilled Syringes Production of Standard Prefilled Syringes Attachment of Safety Features in Prefilled Syringes Available Prefilled Syringes in the Market Baxter BioPharma Solutions BD Medical s Prefilled Segment Catalent Pharma Solutions Cook Pharma s Filling and Packaging Gerresheimer AG s Syringe Designs Unilife Corporation s New Approach West Pharmaceutical Services, Inc. s Prefilled Syringes 2.3 Pen Injectors Insulin Pens Buyer s Guide for Reusable Insulin Pens Technical Considerations for Insulin Pens Technical Considerations for Insulin Cartridges Technical Considerations for Pen Needles Device Considerations User Considerations Market Review of Selected Insulin Pens Autopen 24 and Autopen Classic from Owen Mumford HumaPen Luxura and Luxura HD from Eli Lilly HumaPen Memoir from Eli Lilly NovoPen 3 and NovoPen Junior/Demi from Novo Nordisk OptiClik from Sanofi-Aventis OptiPen Pro from Sanofi-Aventis 2.4 Advanced Injection Devices Insulin Delivery Device Technology Biologic Delivery Device Technology Alternative Delivery Technologies 2.5 Needle-Free Injectors Needleless Injector from Injex Jet Syringes from Injex Syrijet PenJet Needle-Free Injector for Human Growth Hormones 3. AWARD WINNING SYRINGES 3.1 Episure AutoDetect Syringe 3.2 ConfiDose 3.3 Humatrope Reconstitution Devices 3.4 Vascez Plungerless Syringe 3.5 Powr Syringe Injector 3.6 NovoFine Autocover Automatic Safety Pen Needle 3.7 Rev Vac Auto-Retractable Vacuum Safety Syringe 4. SYRINGE INDUSTRY: OVERVIEW 4.1 Common Diseases Transmitted by Unsafe Needle Use and Needlesticks Medical Imaging Markets 3

4 4.2 Most Common Instances of Needlestick Injuries 4.3 Needle Phobia and Patients Anxieties 4.4 Global Transition to Safety Medical Devices 4.5 U.S. Regulation 4.6 Worldwide Regulation 4.7 Enforcing Compliance with Sharps Safety Legislation 4.8 Example of an OSHA Violation 4.9 Target Market Awaiting Premium Products 4.10 Current Types of Safety Syringes Safety Syringes with a Needlestick Protection Device Needle Guard Needle Sheath Retractable Syringes Spring-Based, Non-Controlled, Retracting Needle Syringe 4.11 Need for Safety Syringe Products 4.12 Limitations of Existing Clinical Syringes 4.13 Limitations of Existing Prefilled Syringes 4.14 Market Expansion for Safety Syringes 4.15 Technological Advancements in Disposable Syringes 4.16 Reconstitution inside Sterile Syringes Vetter Lyo-Ject 4.17 Plungerless Prefilled Syringes 4.18 The Disposable UniJect 4.19 Needle-Free Injection 5. DISPOSABLE SYRINGES: MARKET ANALYSIS 5.1 Volume of Syringes Used in Healthcare 5.2 Syringe Sizes Required for Injectable Drugs 5.3 Domination of Syringes in Parenteral Drug Delivery Market 5.4 Global Market for Disposable Syringes Global Market for Disposable Syringes by Product Segmentation Global Market for Safety Syringes by Segmentation Combined Market for Injection Devices 5.5 U.S. Market for Hypodermic Safety Syringes Disposable Syringes: U.S. Market Segments Types of Safety Syringes Used in U.S. Hospitals U.S. Adoption of Safety Syringes Competitive Landscape in the U.S Price of Safety Syringes in the U.S U.S. Disposable Syringe Market U.S. Safety Hypodermic Syringe Market 5.6 European Market for Disposable Syringes European Market for Safety Syringes 5.7 Prefill Market Trends The Shift from Vials to Prefilled Syringes Prefilled Syringes: Market Dynamics Importance of Prefilled Syringes to Extend Brand Life Biggest Markets for Prefilled Syringes Dealing with the Latest Trends in Prefilled Syringe Market Market Opportunities for Prefilled Syringes Pharmaceutical Share of Key Prefilled Therapeutic Market Specialty Pipeline Drugs Targeted for Use with Prefilled Syringes Therapeutic Usage of Prefilled Syringes Anti-Infectives in Prefilled Syringes Medical Imaging Markets 4

5 Cardiovascular Drugs in Prefilled Syringes Central Nervous System Drugs in Prefilled Syringes Hematology Drugs in Prefilled Syringes Human Growth Hormones in Prefilled Syringes Musculoskeletal Drugs in Prefilled Syringes Obstetrics Drugs in Prefilled Syringes Oncology Drugs in Prefilled Syringes Vaccines in Prefilled Syringes Flexible Administration Requirements of Prefilled Syringes Biotech Blockbusters Available in Prefilled Syringes Selected Drugs Available in Prefilled Syringes Ovidrel Prefilled Syringe Enbrel Prefilled Syringe Biocon s Prefilled Safety Syringes Pegasys Afluria Enzira Fluzone Vaccine Novolin N FlexPenO Prefilled Insulin Syringes NovoLog Insulin Prefilled Syringe GlaxoSmithKline s Vaccines in Prefilled Syringes Selected Providers of Syringe Prefilling Services and Products Althea Technologies, Inc Althea s Clinical Manufacturing Althea s Fill/Finish Services Althea s Contract Manufacturing Baxter International, Inc Baxter s Contract Manufacturing Baxter s Fill/Finish Services Baxter s Prefilled Syringes Capability Baxter s Vials Baxter s Cartridges Becton Dickinson and Company BD s Prefilled Syringe Services BD Hypak SCF BD Sterifill SCF BD Physioject BD Liquid Dry Disposable Pen Injector BD Pens Customized Self-Injection Systems BD Soluvia Prefillable Microinjection System Catalent Pharma Solutions, Inc Hyaluron Contract Manufacturing Hyaluron s Syringe Filling Vetter Pharma Fertigung GmbH Vetter s Development Service Vetter s Commercial Manufacturing Global Market for Prefilled Syringes Steady Growth in Consumption of Prefilled Syringe Units U.S. Market for Prefilled Syringes Rapid Adoption of Prefilled Syringes for Injectables Pharmaceutical Consumption of Prefilled Syringes Market for Pharmaceutical Prefilled Syringes Global Market for Prefilled Pain Management Drugs Global Sales of Enbrel in Prefilled Syringes Global Market for Prefilled Psoriasis Drugs Medical Imaging Markets 5

6 Global Market for Prefilled Anemia Drugs Global Market for Prefilled Disposable Insulin Delivery Devices Global Market for Insulin in Various Devices Global Market for Oncology Drugs in Prefilled Syringes Global Market for Multiple Sclerosis Drugs in Prefilled Syringes Market Leaders in Multiple Sclerosis Drugs in Prefilled Syringes Global Market for Prefilled Arthritis Drugs Global Market for Vaccines in Prefilled Syringes Market Leaders in Injectable Vaccines Market Leaders in Injectable Anticoagulants Market Leaders in Injectable Anti-Inflammatory Drugs Market Leaders in Injectable Hematology Drugs Market Leaders in Injectable Obstetrics Drugs 5.8 Insulin Pens: Market Analysis Disposable Insulin Pens Refillable Pens Pen Needles Benefits and Patient Preferences of Insulin Pens Disadvantages of Pen Syringes Insulin Pens and Hospital Bills Market for Insulin Pen 5.9 Global Market for Auto-Injectors/Auto-Infusers U.S. Leaders in Insulin Pump Market 5.10 The Growth Market for Self-Injection 6. COMPANY PROFILES 6.1 Abbott Laboratories Abbott s Syringe Products Precision Sure-Dose syringes Humira Prefilled Syringe Humira Pen 6.2 Albert David Limited 6.3 Alshifa Medical Syringes Manufacturing Company Ltd. 6.4 Althea Technologies, Inc. 6.5 Baxter International, Inc Baxter s Anesthesia Business Baxter s Biosurgery Baxter s Clinical Nutrition Business Baxter s Hemophilia Therapies Baxter s Infusion Systems Baxter s Pharmaceuticals and IV Solutions Baxter s Renal Products Baxter s Business Performance 6.6 Becton, Dickinson & Co BD s International Operations BD Medical Business Segment BD Diagnostics BD Biosciences BD s Geographic Performance BD s Role in Designing Devices for Safe and Effective Injections and Infusions BD s Safety-Engineered Devices BD Auto-Disable Syringes BD s Insulin Syringes BD s Allergy Syringes Medical Imaging Markets 6

7 BD s Tuberculin Syringes BD s Syringes and Needles BD s Safety-Lok Safety Syringes BD s Safety Glide Syringes BD s Eclipse Needles BD s Integra Syringes BD s PosiFlush Prefilled Syringes 6.7 B. Braun B. Braun s Hospital Care Division B. Braun s Aesculap Division B. Braun s Out-Patient Market (OPM) Division B. Braun s Avitum Division B. Braun s Overall Business Performance Hospital Care Division s Business Aesculap Division s Business OPM Division s Business Avitum Division s Business B. Braun s Syringe Products Sterican insulin needle Omnifix 100 Duo Omnifix 100 Solo Injekt 40 Duo Injekt 40 Solo Omnifix 40 Duo Omnifix 40 Solo Omnican Omnican Omnican Omnican Omnican Pen Omnican fine 6.8 Bioject Medical Technologies, Inc Bioject s Technology Bioject s Products Biojector Bioject s Drug Reconstitution System Vitajet ZetaJet 6.9 Catalent Pharma Solutions, Inc Catalent s Development and Clinical Services Segment Catalent s Oral Technologies Segment Catalent s Sterile Technologies Segment Catalent s Packaging Services Segment Catalent s Syringe Solutions 6.10 C.R. Bard, Inc Bard s Vascular Business Bard s Urology Business Bard s Oncology Business Bard s Surgical Specialties Business Bard s Syringe Products Bard s Piston Syringes Bard s Bulb Syringes 6.11 Coeur, Inc Angiographic Syringes from Coeur CT Syringes from Coeur Medical Imaging Markets 7

8 6.12 Covidien Ltd Covidien s Medical Device Segment Covidien s Pharmaceutical Segment Covidien s Medical Supplies Segment Covidien s Syringes and Needles Magellan Safety Needles Magellan Safety Needle and Syringe Combination Magellan Insulin Safety Syringe Magellan Tuberculin Safety Syringe Magellan Safety Blood Collection Device Monoject Insulin Safety Syringe Monoject Tuberculin Safety Syringe Monoject 3 ml Safety Syringe Monoject 6 ml Safety Syringe Monoject 12 ml Safety Syringe SoftPack Hypodermic Needles Rigid Pack Hypodermic Needles Rigid Blunt Cannulas Soft Pack Tuberculin Syringes Rigid Pack Tuberculin Syringes SoftPack Insulin Syringes Rigid Pack Insulin Syringes Allergy Trays with Permanently Attached Needles 6.13 Henke-Sass, Wolf GmbH Selected Products from Henke-Sass Two-Part Disposable Syringes 1-50 ml Three-Part Disposable Syringes 1-30 ml Disposable Needles HSW FINE-JECT 6.14 Hindustan Syringes & Medical Devices, Ltd Insulin Syringes from HMD HMD s Single-Use Needles HMD s Single Use Syringes 6.15 Hi-Tech Medical Products Ltd Hyaluron Contract Manufacturing (HCM) HCM s Major Markets HCM s Facility Inova SV-122 Syringe Filler Inova H3-5V Syringe Filler Inova VFVM-3031 Vial Filler 6.17 International Medication System Ltd Delivery Systems from IMS PCA Products from IMS Phytonadione Injection USP Lidocaine HCL Jelly, USP 2% 6.18 Life-Shield Products, Inc MedPro Safety Products, Inc MedPro s Targeted Markets MedPro s Products Blood Collection Safety Needle Winged Safety Blood Collection Set Safety Syringe with Anti-Blunting Feature Prefilled Safety Syringes Key-Lok Needleless IV Systems 6.20 Merit Medical Systems, Inc Merit s Inflation Devices Medical Imaging Markets 8

9 Merit s Hemostasis Valves Merit s Vascular Access Products Merit s Diagnostic Catheters, Guide Wires and Torque Devices Merit s Angiography and Accessories Merit s Safety and Waste Management Systems Merits Obesity Products Merit s Drainage Catheters and Accessories Merit s Parentesis and Pericardiocentesis Catheters Merit s Therapeutic Infusion Catheters Merit s Dialysis and Interventional Nephrology Products Coronary Control Syringes Medallion Syringes RXP Syringe VacLok Syringes Merit s Manufacturing Facilities 6.21 Milestone Scientific Milestone Scientific s Product Platform STA Single Tooth Anesthesia System (STA System) CompuDent CompuMed The Wand The SafetyWand 6.22 Novo Nordisk A/S Novo Nordisk s Global Diabetes Care Business Novo Nordisk s Diabetes Care Business in North America Novo Nordisk s Diabetes Care Business in Europe Novo Nordisk s International Business in Diabetes Care Novo Nordisk s Diabetes Care Business in Japan and Korea Insulin Pens and Needles from Novo Nordisk Pipeline Progress in Novo Nordisk Novo Nordisk s Modern Insulin Portfolio 6.22 Owen Mumford Ltd Autopen Autoject Unifine Pentips UniGuard 6.23 Plas-Pak Industries, Inc Disposable Veterinary Syringes Dual Syringe and Dental Syringe from Plas-Pak Manual Dual Syringes 6.24 Retractable Technologies, Inc Retractable Technologies VanishPoint Products 6.25 Revolutions Medical Corporation RevVac Safety Syringe 6.26 Safety Syringes, Inc UltraSafe Needle Guards UltraSafe Passive Needle Guard UltraSafe Passive Needle Guards for Luer Lock and Luer Slip Syringe UltraSafe Automated Assembly UltraSafe Product Development 6.27 Smiths Medical International/Medex, Inc Smiths Medical s Markets Smiths Medication Delivery Segment Smiths Vital Care Segment Smiths Safety Segment Medical Imaging Markets 9

10 Syringes from Smiths Hypodermic Needle-Pro Fixed Needle TB Syringe Hypodermic Needle-Pro Device Hypodermic Needle-Pro Device & Syringe Hypodermic Needle-Pro Device for Insulin Injections Hypodermic Needle-Pro Fixed Needle Insulin Syringe 6.28 Star Syringe Ltd Star Syringe s Alliances Star Syringe Products K Safety Technology: K1 Auto-disable Syringe Mechanism K3 Safety Cap K5 Aspiration 6.29 Terumo Medical Corporation Terumo s Syringe Products SurGuard2 Syringes with Safety Needle SurGuard2 Safety Needles Terumo Hypodermic Needles Terumo Hypodermic Syringes without Needle Terumo Tuberculin Syringes Terumo Hypodermic Syringes with Needle SurSaver 1CC syringes with Low Dead Space Terumo Dental Needles Terumo Spinal Needles SurGuard Safety Insulin Syringes Terumo Insulin Syringes Thinpro Insulin Syringes for Retail Customers 6.30 UltiMed, Inc UltiCare Insulin Syringes UltiCare Pen Needles 6.31 Unilife Medical Solutions, Ltd Unilife s Solutions Prefilled Syringes from Unilife Clinical (Hypodermic) Syringes from Unilife Unilife s Self Injection Systems Auto-Injectors Unilife s Auto-Infusers Unilife s Syringe Products Unifill Syringe Unitract 1 ml Syringes Unifill Select Unifill Rita Unifill EZMix syringes Unilife Autoinfuser 6.32 Vetter Pharma-Fertigung GmbH & Co Vetter Services and Solutions Vetter s Dual-Chamber Technology 6.33 Vita Needle Company, Inc Disposable Stainless Steel Needle Blunts from Vita Needle Teflon Dispensing Needles Vita Needle s Polypropylene Needles Vita Needle s Taper Tip Needles 6.34 West Pharmaceutical Services, Inc West s Business Segments Packaging Systems Segment Delivery Systems Segment Medical Imaging Markets 10

11 West s Syringe Products The West ConfiDose Autoinjector System West s Prefillable Syringes Plungers Needle Shields Tip Caps 6.35 Wuxi Yushou Medical Appliances Co., Ltd Ypsomed Holding AG Future Trends in Self Medication: Ypsomed Holding s Perceptions ServoPen YpsoPen Twist UnoPen LyoTwist YpsoMate Mylife OmniPod insulin patch pump APPENDIX Appendix 1: Global Market for Conventional Injectables Appendix 1.1: Global Market for Drug Delivery Devices Appendix 1.2: Evolving Trends in Insulin Delivery Appendix 1.2.1: Alternative Modes of Insulin Delivery Appendix 1.2.2: Insulin Injection Ports Appendix 1.2.3: Continuous Subcutaneous Insulin Infusion Pumps Appendix 1.2.4: Transdermal Patches Appendix 1.2.5: Inhalable Insulin Devices Appendix 1.3: Global Burden of Diabetes Appendix 1.3.1: Market for Insulin Delivery Devices Appendix 1.3.2: Leaders in Insulin Delivery Devices Appendix 1.3.3: Global Insulin Consumption Appendix 1.3.4: Global Market for Insulin Appendix 1.4: Global Diabetes Care Market Share by Company Appendix 1.4.1: Global Insulin Market by Molecule Type Appendix 1.4.2: Global Insulin Market by Geography Appendix 1.4.3: Global Diabetes Care Market by Treatment Class Appendix 1.5: Growth of Modern Insulin Appendix 1.5.1: Global Modern Insulin Market Shares Appendix 1.6: U.S. Insulin Market by Segment Appendix 1.6.1: U.S. Modern Insulin Volume Market Shares Appendix 1.7: E.U. Insulin Market by Segment Appendix 1.7.1: E.U. Modern Insulin Volume Market Share by Company Appendix 1.8: Chinese Insulin Market by Segment Appendix 1.8.1: China Insulin Volume Market Shares Appendix 1.9: Japan Insulin Market by Segment Appendix 1.9.1: Japan Modern Insulin Market Share by Company Appendix 2: Sharps Safety Products Appendix 3: Syringe Needle Terminology Appendix 4: Medication Errors and Syringe Safety Appendix 4.1: Injectable Medication Errors Appendix 4.2: Frequency of Syringe Usage Appendix 4.3: Labeling Injectable Medications Appendix 4.4: Challenges of Labeling Appendix 4.5: Benefits of a Write-On Stripe Appendix 4.6: Nurses Influence on Selection of Sharp Devices Appendix 4.7: Needlestick Injuries Medical Imaging Markets 11

12 Appendix 4.8: Prevention of Needlestick Injuries Appendix 4.9: Protection from Needlestick Injuries INDEX OF FIGURES Figure 2.1: Filling and Packaging of Prefilled Syringes Figure 4.1: Most Common Instances When Needlesticks Occur Figure 4.2: Needlestick Injuries in Massachusetts at Healthcare Facilities with Safety vs. Standard Syringes Figure 4.3: Indicative Pricing Chart for Safety Features Figure 5.1: Syringe Sizes Required for Injectable Drugs Figure 5.2: Global Market for Disposable Syringes, Figure 5.3: Global Market for Disposable Syringes by Segmentation, 2012 Figure 5.4: Global Market for Safety Syringes by Segmentation (Total $1.96 Billion), 2011 Figure 5.5: Combined Market for Drug Delivery Syringe Devices, Figure 5.6: Breakdown of U.S. Syringe Market Figure 5.7: Types of Safety Syringes used in the U.S. Healthcare Facilities Figure 5.8: Percentage of U.S. Adoption of Safety Syringes, Figure 5.9: The Total Disposable Syringe Market in the U.S., Figure 5.10: The U.S. Market for Hypodermic Safety Syringes, Figure 5.11: European Overall Market for Disposable Syringes, Figure 5.12: European Adoption of Safety Syringes, Figure 5.13: Market Share of Prefilled Syringes by Geography Figure 5.14: Number of Drugs in the Core Therapeutic Areas for Prefilled Syringes Figure 5.15: Global Market for Prefilled Syringes, Figure 5.16: Steady Growth of Global Prefilled Syringe Unit Consumption, Figure 5.17: World vs. U.S. Market for Prefilled Syringes, Figure 5.18: Consumption of Prefilled Syringes by Pharmaceutical Company Figure 5.19: Pharmaceutical Consumption of Prefilled Syringes by Therapeutic Drug Class Figure 5.20: Global Market for Prefilled Pain Management Drugs, Figure 5.21: Global Sales of Enbrel in Prefilled Syringes Figure 5.22: Global Market for Prefilled Psoriasis Drugs, Figure 5.23: Global Market for Prefilled Anemia Drugs, Figure 5.24: Global Market for Prefilled Insulin, Figure 5.25: Growth of Prefilled Insulin Devices and Decline of Vials and Syringes Figure 5.26: Global Market for Oncology Drugs in Prefilled Syringes, Figure 5.27: Global Market for Multiple Sclerosis Drugs in Prefilled Syringes, Figure 5.28: Market Share for Multiple Sclerosis Drugs in Prefilled Syringes by Company Figure 5.29: Global Market for Arthritis Drugs in Prefilled Syringes, Figure 5.30: Percent Growth of Vaccines in Prefilled Syringes, Figure 5.31: Market Share for Vaccines in Prefilled Syringes by Company Figure 5.32: Market Share for Anti-Coagulants in Prefilled Syringes by Company Figure 5.33: Market Share for Anti-Inflammatory Drugs in Prefilled Syringes Figure 5.34: Market Share for Hematology Drugs in Prefilled Syringes by Company Figure 5.35: Market Share for Obstetrics Drugs in Prefilled Syringes by Company Figure 5.36: Global Market for Insulin Pen, Figure 5.37: Global Market for Auto-Injectors/Auto-Infusers, Figure 5.38: U.S. Leaders in Insulin Pumps Figure 5.39: Market for Self-Injection Syringes, Figure 6.1: BD Business Performance by Segment, 2012 Figure 6.2: Performance of BD Medical Segment, 2012 Figure 6.3: Performance of BD Diagnostics Segment, 2012 Figure 6.4: BD s Geographic Performance, 2012 Figure 6.5: Share of Bioject s Business by Customer Figure 6.6: Bioject s Business by Product Line Figure 6.7: Bioject s Business by Geography Medical Imaging Markets 12

13 Figure 6.8: Catalent s Revenue by Segment Figure 6.9: Retractable Technologies Business by Geography Figure 6.10: Smiths Market by Segment Figure 6.11: Insulin Market by Geography, Figure 6.12: Global Insulin Market by Manufacturers, Figure A.1.1: Global Market for Conventional Injectables, Figure A.1.2: Global Market for Injection, Infusion and Vascular Access Devices, Figure A.1.3: Global Burden of Diabetes, Figure A.1.4: Global Market for Insulin Delivery Devices, Figure A.1.5: Insulin Delivery Devices Worldwide Market Shares by Company Figure A.1.6: Insulin Consumption in Selected Countries Figure A.1.7: Global Market for Insulin, Figure A.1.8: Global Diabetes Care Market Share by Company, 2012 Figure A.1.9: Global Insulin Market Breakup by Molecule (~ $19 Billion), 2012 Figure A.1.10: Global Insulin Market by Geography, 2012 Figure A.1.11: Global Diabetes Care Market by Treatment Class, Figure A.1.12: Shares of Human Insulin and Modern Insulin in Global Insulin Market, Figure A.1.13: Global Insulin Volume Market Shares by Company, Figure A.1.14: U.S. Insulin Market by Segment, Figure A.1.15: U.S. Modern Insulin Volume Market Share by Company, Figure A.1.16: E.U. Insulin Market by Segment, Figure A.1.17: E.U. Modern Insulin Volume Market Share by Company, Figure A.1.18: Chinese Insulin Market by Segment, Figure A.1.19: China Insulin Volume Market Share by Company, 2012 Figure A.1.20: Japan Insulin Market by Segment, Figure A.1.21: Japan Modern Insulin Market Share by Company, Figure A.4.1: Timing of Needlestick Injuries INDEX OF TABLES Table 2.1: Components of a Prefilled Syringe Table 2.2: Key Advantages of Prefilled Syringes Table 2.3: Insulin Pens Available in the U.S. Table 2.4: Types of Insulins Used in Cartridges Table 2.5: Aspects of Insulin Pens to be considered Table 2.6: User Characteristics of Insulin Pens Table 5.1: Selected Injectable Therapeutics and Vaccines Available in the U.S. Market Table 5.2: Key Advantages of Prefilled Syringes Table 5.3: Pharmaceutical Share of Key Prefilled Therapeutic Market Table 5.4: Key Prefilled Products Table 5.5: Biotech Blockbusters Available in Vials and Prefilled Syringes Table 6.1: Albert David s Syringes with Needles Table 6.2: Albert David s Needles Table 6.3: Syringes from Alshifa Table 6.4: BD s Auto-Disable Syringes Table 6.5: Insulin Syringes from BD Table 6.6: BD s Allergy Syringes Table 6.7: BD s Tuberculin Syringes Table 6.8: BD s Sterile, Single-Use Syringes and Needles Table 6.9: BD s Safety-Lok Safety Syringes Table 6.10: BD s Safety Glide Syringes Table 6.11: BD s Eclipse Syringes Table 6.12: BD s Integra Syringe Table 6.13: BD s PosiFlush Prefilled Syringes Table 6.14: Bard s Piston Syringes Medical Imaging Markets 13

14 Table 6.15: Bard s Bulb Syringes and Trays, 2009 Table 6.16: Angiographic Syringes from Coeur Table 6.17: CT Syringes from Coeur Table 6.18: HMD s Dispovan Insulin Syringes Table 6.19: HMD s Single-Use Needles Table 6.20: HMD s Single Use Syringes Table 6.21: Hi-Tech Single-Use Syringes Table 6.22: Hi-Tech s Single-Use Insulin Syringes Table 6.23: HCM s Contract Manufacturing Categories Table 6.24: Syringes from IMS Table 6.25: PCA Syringes from IMS Table 6.26: Phytonadione Injection USP from IMS Table 6.27: Lidocaine Prefilled Syringes from IMS Table 6.28: Life-Shield s Syringe Products Table 6.29: Estimated Market for MedPro s Targeted Product Sectors Table 6.30: Autopen Products from Owen Mumford Table 6.31: Autoject Products from Owen Mumford Table 6.32: Unifine Products from Owen Mumford Table 6.33: Retractable Technologies VanishPoint Syringes Table 6.34: Smiths Pro Fixed Needle TB Syringes Table 6.35: Smiths Needle-Pro with Needle Protection Devices Table 6.36: Smiths Needle-Pro Syringe and Needle with Needle Protection Device Table 6.37: Smiths Needle-Pro Needle Protection Device for Insulin Injections Table 6.38: Smiths Needle-Pro Fixed Needle Insulin Syringe Table 6.39: SurGard2 Syringes with Safety Needle Table 6.40: Terumo s SurGard2 Safety Needles Table 6.41: Terumo s Hypodermic Needles Table 6.42: Terumo s Hypodermic Syringes without Needle Table 6.43: Terumo s Tuberculin Syringes Table 6.44: Terumo s Hypodermic Syringes with Needle Table 6.45 Terumo s SurSaver 1 cc Syringes with Low Dead Space Table 6.46: Terumo s Dental Needles Table 6.47: Terumo s Spinal Needles Table 6.48: Terumo s SurGard Safety Insulin Syringes Table 6.49: Terumo s Insulin Syringes Table 6.50: Thinpro Insulin Syringes Table 6.51: UltiMed s UltiCare Insulin Syringes Table 6.52: UltiCare Pen Needles Table 6.53: Vita Needle s Stainless Steel Needle Blunts Table 6.54: Vita Needle s Teflon Dispensing Needles Table 6.55: Vita Needles Polypropylene Needles Table 6.56 Vita Needle s Taper Tip Needles Table A. 1.1: Alternative Modes of Insulin Delivery Table A. 1.2: Types of Insulin Used in Pump Therapy Table A. 1.3: Insulin Pumps Assessed by AFB TECH Company in 2004 and 2008 Medical Imaging Markets 14

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