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1 Volume Multiple Clinical Trial Opportunities are available. Trial opportunities are continually changing. For more information, contact HealthPartners Center for Memory & Aging at or Currently Recruiting! Phase II Intranasal Insulin Study This investigation studies the effect of insulin on cognition and function in individuals with amnestic mild cognitive Impairment (amci) or mild Alzheimer s disease (AD) when delivered as a nasal spray (intranasally). (Study Length = 8 months.) Lundbeck Study (STARBEAM) This investigation studies a medication (Lu AE58054) that is expected to work in conjunction with Aricept for symptomatic treatment in mild-moderate Alzheimer's disease. There is also an option to participate in a 32 week extension study. (Study Length = 28 weeks & an additional 32 weeks.) More Studies on page 2. To support our work call or visit ALZHEIMER S FUNDRAISING BREAKFAST Thank you to everyone who attended our 5th annual Alzheimer s Fundraising Breakfast on June 3. I am happy to report that we raised over $177,000. Once again, we hosted the breakfast at the beautiful Harriet Island Pavilion. See more information and photos on page 3. Ask the Experts: Learn, Meet and Connect Speaker Series. 1 CUE Available per talk. memoryloss@healthpartners.com or call to reserve a place. September 24 October 13 November 5 Dr. Terry Barclay Coping with Memory Loss: Communication, Resources, & Living Well 11:30-Noon Check in/lunch Noon-1:00 PM Talk Keystone Senior Living 2750 N. Victoria St., Roseville. Dr. William Frey Beyond the Basics of Alzheimer s: New Treatments, Approaches & Research 5:30-6:00 PM Check in/dinner 6:00-7:00 PM Talk Keystone Senior Living 3810 Adler Lane, Eagan 1 Dr. Sonia Mosch: Testing for Dementia Diagnosis to Treatment & Real World Implications 11:30 AM to noon-check in/lunch Noon to 1:00 PM Talk Keystone Senior Living 750 Mississippi River Blvd., St. Paul

2 Continued from page 1; We are currently recruiting for Clinical Trial Opportunities. Merck MK Study This is a study in mild-moderate Alzheimer s disease testing a novel drug (MK-8931) that is expected to reduce levels of Abeta, an abnormal protein that is associated with Alzheimer s disease. This study sponsor is testing this agent to see if it has any effects in modifying the disease process. There is an option to participate in an extension study that will last up to 260 weeks. (Study Length = 78 weeks and an additional 260 weeks.) Merck MK Study This is a study in mild cognitive impairment testing a novel drug (MK-8931) that is expected to reduce levels of Abeta, an abnormal protein that is associated with Alzheimer s disease. Mild cognitive impairment is considered an earlier stage of memory loss that may progress to dementia. The decision to study this drug in the mild cognitive impairment population is based on the hypothesis that treating this disease earlier in the process may lead to better outcomes. (Study Length = 112 weeks.) Contact HealthPartners Center for Memory & Aging at or memoryloss@healthpartners.com. Our Dr. Michael Rosenbloom is now the Interim Neurology Head! Our CMA Clinical Director, Dr. Rosenbloom, last year was made assistant professor at the University of Minnesota and also serves as the assistant neurology residency program director. On April 1 he was promoted to interim neurology head at the HealthPartners Department of Neurology. His responsibilities will include supervising a neurology department that includes experts in stroke, dementia, Parkinson s disease, neuro-intensive care, neuro-oncology, neuromuscular disease, and headache. His immediate goals are to continue to foster the growth of inpatient services such as stroke, epilepsy, and Neuro- ICU. Congratulations Dr. Rosenbloom! Brain-Healthy cookbook Offers a Delicious way to Reduce Dementia Risk Looking for a flavorful way to practice brain-healthy eating? We recently read Healthy Eating to Reduce the Risk of Dementia and discovered plenty of delicious ways to promote good brain nutrition. Professor Rayman and her team of experts provide a surprisingly thorough and easy to understand guide to dementia-preventative nutrition. Healthy Eating to Reduce the Risk of Dementia is a great resource for both dementiarelated nutritional education, and satisfying, flavorful recipes that put these nutritional standards to use. We especially recommend the spiced green vegetables and the baked trout with white wine and fennel. Healthy Eating to Reduce the Risk of Dementia: 100 Fantastic Recipes Based on Extensive, In-depth Research in Association with the Waterloo Foundation, 29 Jan 2015, by Margaret Rayman. Living Well Book For tips on how to live well with a dementia diagnosis, go to this on-line resource which is a guide for persons with mild cognitive impairment (MCI) & Early dementia. 2

3 ALZHEIMER S FUNDRAISING BREAKFAST 2015 Mr. Bill Sands, our emcee, welcomed our 300 guests to the event followed by Dr. Rosenbloom who shared his very personal and touching story and his own need for care this past year. Marv Lofquist, a patient from the Center for Memory & Aging and his wife, Elaine spoke about their experience and their journey with Alzheimer s. View the video which was featured at the breakfast and hear the thoughts of Marv and Elaine: Please join us next year for this wonderful event. 1st Row: Drs. Bret Haake & Jared Fine, Dr. Michael Rosenbloom 2nd Row: Marv & Elaine Lofquist and David Lofquist, Marv & Dr. Terry Barclay, Dr. Tom Kottke & Sue DeNuccio 3rd Row: Dr. Leah Hanson & Megan Remark. Thank you to those who contributed to other events! The 4th annual Winnebago Walk/Run Ride Event was held on Saturday, June 20 in Winnebago this year. This year they had the most participants ever, totally 135 and raised around $ for our Center. Thank you to Kathy and her family and friends from the Winnebago Walk/Run Ride Event who raised this generous donation! 3

4 ns Support Alzheimer s Research in your Will. Pat has lost a brother, mother and grandmother to Alzheimer s disease. He doesn t want to watch other family members suffer from this disease, which is why he feels he has a responsibility to support Alzheimer s research. Interested in scheduling a physician or researcher to speak to your group? Recent topics include: Understanding Dementia & Alzheimer s Disease Kevin and Pat Fiske "In this world, if we set a goal to accomplish something, we do it. All it takes is people, time, resources and Strategies for Healthy Brain Aging - money. When I contribute to the Center for Memory and Aging, I'm investing in something important. I'm excited to see what they accomplish." Pat has also included the Center for Memory and Aging in his will and designated a portion of his brother s estate to support our research. "They're a great team and they're all special people," Pat says. "You can really sense their genuine enthusiasm about what they're working on. They're committed to finding a cure and in collaborating with other researchers worldwide. Their attitude is 'We can do this.' It's so humbling to be around these people and be a part of their work. To make a gift today or through your will, contact Chris at or visit Beyond the Basics of Alzheimer's-- New Treatments, Approaches & Research Diagnosis to Treatment and Real World Implications Ask the Experts A Panel Question & Answer Discussion To arrange a speaker, call Ann at or memoryloss@healthpartners.com Watch our latest featured story on WCCO: alzheimers-takes-toll-on-doctor-and-his-family/ Interested in making an appointment? On Tuesdays at the St. Paul Specialty Clinic, the HealthPartners Center for Memory & Aging offers a Diagnostic Clinic Day where patients can see a neurologist, neuropsychologist, geriatric psychiatrist, physician assistant and nurse all at one visit. To make an appointment call and press option 1. How to Donate Secure on-line donations to support research on the treatment and prevention of Alzheimer s disease and other memory disorders can be made at or by clicking 3086.thankyou4caring.org/ memory-and-aging-donations. If you have questions, wish to discuss a planned gift or special bequest, call and select option 2. Gifts made to the Center are processed through Regions Hospital Foundation, a charitable organization that as part of its mission raises funds on behalf of HealthPartners Center for Memory & Aging and other programs in patient care, medical research and education. Visit us at 4

5 Symptoms of Dementia If you are concerned about your memory, speak with you primary care provider or a Neurologist. Memory loss Forgetting conversations and events that happened recently. Disorientation Not knowing where you are and how you got there, getting lost close to home, not knowing what year or month it is. Language problems Difficulty putting thoughts into words, difficulty finding simple words, forgetting what you are trying to say, sometimes even before you have completed saying it. Problems performing usual tasks Planning and making a meal, balancing a checkbook, following a recipe, etc. Misplacing things Losing things or putting them in odd places. Problems with concentrating, abstract thinking and judgment Wearing inappropriate clothing, giving money or private financial information to telemarketers, having difficulty understanding and using numbers, etc. Loss of interest and initiative Discontinuing pursuit of their usual activities and interests, watching TV for extended periods of time and sleeping a great deal. Changes in mood, behavior and personality Mood swings, irritability, aggressiveness, depression, anxiety, suspiciousness, loss of inhibitions and wandering. Changes in visual and spatial perception Difficulty understanding and interpreting what is seen. Additional Alzheimer s Risk Factors. Consider these Risk Factors when talking to your physician. Vitamin D deficiency markedly increases the risk of dementia and Alzheimer s disease. It is extremely prevalent among the elderly and is not uncommon in younger adults as well. It is associated with an increased risk of stroke, therefore, low blood vitamin D concentrations increase the risk of dementia and Alzheimer s disease through neurodegenerative and vascular mechanisms. To reduce the risk for Alzheimer s disease, have a blood test to determine the vitamin D level and if it is low, speak to a physician about how to correct it. Aging is a major risk factor for Alzheimer s disease. The incidence and the prevalence rate for Alzheimer s disease doubles every 5 years after the age of 65. However, some individuals develop Alzheimer s disease in their 50 s or rarely even earlier. Family history of Alzheimer s disease increases the risk for developing Alzheimer s disease. Having the APOE4 genotype significantly increases the risk for late onset Alzheimer s disease. Diabetes is associated with an increased risk for developing Alzheimer s and decline in cognitive function. Obesity, or having a large amount of abdominal fat, increases the risk for Alzheimer s disease. Poor Diet that contains a high intake of total fat, saturated fat, and total cholesterol increases the risk of dementia. Reduced consumption of fish containing omega-3 fatty acids also increases the risk for age-related cognitive decline and Alzheimer s disease. Smoking increases the risk for Alzheimer s disease. Lack of mental activity and exercise in mid-life may be a risk factor for developing Alzheimer s. Head trauma with loss of consciousness may be a risk factor for Alzheimer s disease. To Donate call or go to 5

6 Thank you to our 2015 Breakfast Sponsor! Thank you to our Exhibitors and Community Partners! COVENANT VILLAGE OF GOLDEN VALLEY A Covenant Retirement Community Thank you to our 2015 Registration Sponsor! Thank you to our 2015 Music Sponsor! 6