EXTAVIA (interferon beta-1b) Do not take EXTAVIA (interferon beta-1b) if you are allergic

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2 If you ve been diagnosed with a relapsing form of multiple sclerosis (MS), or you are looking to learn about a treatment option, this guide outlines the key facts to remember about EXTAVIA (interferon beta-1b). Making the right decision about treatment is important. So talk to your health care provider (HCP) about your individual treatment needs and decide whether EXTAVIA is right for you. Indication EXTAVIA (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with MS. EXTAVIA will not cure MS but may decrease the number of flare-ups of the disease. Important Safety Information Do not take EXTAVIA (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or to mannitol. 2 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

3 What Is MS? understanding my condition is important What Is Multiple Sclerosis? 1

4 What Is MS? 4 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

5 What Does My Diagnosis Mean? MS is a disease of your central nervous system (CNS) not a disease of your heart or soul. MS doesn t have to change your values, your love for family and friends, your outlook, or the passion you bring to life. Don t forget life s simple pleasures. In addition to disease education and finding an effective treatment, you may find that inspiration is also very important. Remember to look for things that bring you joy. Following diagnosis, simple day-to-day pleasures may help you cope with new challenges. Still, it may not be easy. The emotions and uncertainty you may feel at learning you have a chronic disease or at having to try a new therapy are not easy to prepare for. By reading through this brochure, you are taking an important first step towards learning about MS and an available treatment option. Together, you and your HCP will decide what treatment option best suits you. Indication EXTAVIA (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with MS. EXTAVIA will not cure MS but may decrease the number of flare-ups of the disease. Important Safety Information Do not take EXTAVIA (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or to mannitol. 5

6 Healthy nerve fiber with protective myelin sheath. Figure 2 Lesion Nerve fiber exposed due to myelin sheath erosion. Figure 3 The CNS and the peripheral nervous system. Nerve fiber severed due to myelin sheath erosion. Figure 1 Figure 4 6 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

7 What Exactly Is MS? MS is a chronic disease that affects the CNS, which is made up of the brain, spinal cord, and nerve fibers to the eyes. MS is widely thought to be an autoimmune disease, in which a mistaken immune response launches an attack on the body s own tissue. The destruction that results can disrupt the proper functioning of the CNS. The CNS is made up mainly of nerve cells, which carry messages within the body. All the information sent to and from your brain and spinal cord is controlled by the CNS (Figure 1). MS puts these nerve cells and the messages they carry at risk. As a result, some people with MS may experience a decrease or loss of certain functions. Nerve fibers have a protective insulation around them, which is called myelin (Figure 2). Myelin helps ensure that messages are transmitted successfully. When myelin is damaged, it can cause scarring or lesions in the brain and the spinal cord (Figure 3) This damage can slow or block the messages from traveling throughout your body (Figure 4) Some MS patients affected by this nerve cell communication breakdown may experience a decrease or loss of certain functions 7

8 8 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

9 How Many People Have MS? And Who Gets It? MS affects about 2.5 million people worldwide. Approximately 400,000 people have been diagnosed with MS in the United States, with about 200 new cases diagnosed every week. People with MS are generally between 20 and 40 years of age when they experience their first symptoms. However, initial symptoms can also appear earlier or later. Who gets MS? Caucasians are more than twice as likely to develop MS : Women are twice as likely to develop MS : 9

10 Is All MS the Same? MS is a very individual disease. Patient journeys vary greatly. But, in general, a person diagnosed with MS can be classified into 1 of 4 main categories. Eighty-five of 100 newly diagnosed MS patients have relapsing-remitting MS (RRMS), which is characterized by a series of relapses followed by a complete or partial remission of symptoms Secondary progressive MS begins as relapsingremitting but years later may become worse, with gradual progression occurring with or without remissions and relapses Ten of every 100 people in the MS population have primary progressive MS. This type of MS is characterized by a gradual decline with no clear relapses or remissions, and no more than temporary or slight relief of symptoms Five of every 100 people in the MS population have progressive relapsing MS. This type of MS is characterized by slow yet steady disease progression that occurs along with relapses Indication EXTAVIA (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with MS. EXTAVIA will not cure MS but may decrease the number of flare-ups of the disease. 10 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

11 What s your clinical pattern at diagnosis? 85% of patients have RRMS 10% of patients have primary progressive MS 5% of patients have progressive relapsing MS Important Safety Information EXTAVIA can cause serious side effects, including: Liver Problems Including Liver Failure. Symptoms of liver problems may include yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting, bruising easily, or bleeding problems. Your healthcare provider will do blood tests to check for these problems while you take EXTAVIA. 11

12 12 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

13 What Causes MS? No one knows for certain what causes MS. It is generally thought that an autoimmune response causes MS. However, what triggers the response and what can be done to stop it are ongoing areas of intense research. But there s more research happening today to advance our understanding of MS than ever before. Important Safety Information EXTAVIA can cause serious side effects, including: Serious Allergic Reactions. Serious allergic reactions can happen quickly and may happen after your first dose of EXTAVIA or after you have taken EXTAVIA many times. Symptoms may include difficulty breathing or swallowing, swelling of the mouth or tongue, rash, itching, or skin bumps. Depression or Suicidal Thoughts. Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying, new or worse depression (sinking feeling or sadness), new or worse anxiety (feeling uneasy, nervous, or fearful for no reason), trouble sleeping (insomnia), acting aggressive, being angry, or violent, acting on dangerous impulses, hallucinations, other unusual changes in behavior or mood. 13

14 What Are the Symptoms of MS? MS symptoms, symptom severity, and symptom duration vary from person to person. MS symptoms show up differently depending on where nerve damage has occurred. For example, damage to one part of the brain may lead to difficulty thinking, whereas damage to another part of the brain may lead to a physical disability. Silent damage can also occur. This is when damage is taking place, but no outward symptoms are present. If symptoms recur or worsen, or if new symptoms appear, these periods are called relapses. By definition, a relapse must last at least 24 hours and follow a previous episode by at least 30 days. Most relapses last from a few days to weeks or months A relapse can be mild or severe Be sure to talk to your doctor about any new or worsening symptoms you may have. 14 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

15 How Is MS Diagnosed? Diagnosing MS is often not easy or straightforward. One reason is that many diseases produce symptoms similar to MS. Another is that the noticeable symptoms of MS can take years to show up and sometimes the initial symptoms of disease may not return for a period of time. Getting a diagnosis as early as possible is important in helping to manage the disease. That s because research suggests early treatment may reduce the frequency of subsequent episodes. Important Safety Information Other possible serious side effects with EXTAVIA include: Heart Problems. EXTAVIA may worsen heart problems including congestive heart failure. Symptoms of heart problems may include swollen ankles, shortness of breath, decreased ability to exercise, fast heartbeat, tightness in chest, increased need to urinate at night, not being able to lay flat in bed. Injection Site Problems. Serious skin reactions can happen in some people, including areas of severe damage to skin and the tissue below the skin (necrosis). These reactions can happen anywhere you inject EXTAVIA. Symptoms of injection site problems may include swelling, redness, or pain at the injection site, fluid drainage from the injection site, breaks in your skin or blue-black skin discoloration. Change your injection site each time you inject EXTAVIA as it will lessen the chance of you having a serious skin reaction. Avoid injecting EXTAVIA into an area of the skin that is sore, reddened, infected, or has other problems. 15

16 How Do My Doctor and I Choose an MS Treatment? Choosing an MS treatment is a big decision but you aren t expected to do this on your own. Weighing your treatment options involves several considerations that your HCP can discuss with you. These may include each drug s effectiveness, its side effects, and your individual lifestyle. Partnering with your HCP and communicating openly are essential to getting the treatment that s right for you. So don t be shy about asking questions or sharing your concerns. To make sure you get all the answers you need, read through the HCP discussion questions on page 34. These questions will help you have a more productive discussion with your HCP. Indication EXTAVIA (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with MS. EXTAVIA will not cure MS but may decrease the number of flare-ups of the disease. 16 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

17 a treatment that s right for me Why Use EXTAVIA? Why Use EXTAVIA? 2

18 Why Use EXTAVIA? 18 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

19 Why Use EXTAVIA? EXTAVIA is a prescription medication approved for the treatment of relapsing forms of MS. EXTAVIA has been shown to reduce the frequency of episodes in people with relapsing forms of MS, and also in people who have had only a single episode and whose MRI findings are consistent with MS. Your HCP may recommend EXTAVIA for several reasons. Here are a few: EXTAVIA is effective EXTAVIA is proven to delay the second episode in patients with clinically isolated syndrome (CIS) EXTAVIA has been shown to reduce the rate of moderate-tosevere relapses The recommended dose of EXTAVIA is 0.25 mg taken every other day through manual injection or with the EXTAVIA Auto-Injector II EXTAVIA doesn t need to be refrigerated as an unmixed powder. After mixing, however, EXTAVIA must be used right away or refrigerated and used within 3 hours. EXTAVIA is administered subcutaneously. EXTAVIA is administered just under the skin using a short needle. Important Safety Information Other possible serious side effects with EXTAVIA include: Flu-like Symptoms. EXTAVIA can cause flu-like symptoms including fever, chills, tiredness, sweating, and muscle aches when you first start to use it. These symptoms may decrease over time. Taking medicines for fever and pain relief on the days you are using EXTAVIA may help decrease these symptoms. Seizures. Some people have had seizures while taking EXTAVIA, including people who have never had seizures before. It is not known if the seizures were related to MS, to EXTAVIA, or to a combination of both. If you have a seizure after taking EXTAVIA call your healthcare provider right away. 19

20 20 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

21 What Is EXTAVIA? EXTAVIA is one of several disease-modifying therapies called interferons. Interferon beta-1b is the active ingredient in EXTAVIA and is based on a protein that s found naturally in your body. EXTAVIA is a prescription medication approved for the treatment of relapsing forms of MS to reduce the frequency of episodes. EXTAVIA is also for patients who have had a single episode and MRI findings consistent with MS. Although EXTAVIA is proven effective, the exact mechanism in patients with MS is unknown. Important Safety Information Other possible serious side effects with EXTAVIA include: Blood Problems. You may have a drop in the levels of infectionfighting white blood cells, red blood cells, or cells that help you form blood clots. If drops in levels are severe, they can lessen your ability to fight infections, make you feel tired or sluggish, or cause you to bruise or bleed easily. Risk to Pregnancy: EXTAVIA can harm your unborn baby. EXTAVIA may cause you to lose your baby (miscarry). If you become pregnant while taking EXTAVIA call your healthcare provider right away. You and your healthcare provider should decide if you should continue to take EXTAVIA. Most Common Side Effects: The most common side effects of EXTAVIA include low white blood cell count, increases in your liver enzymes, headache, increase in your muscle tension, pain, rash, problems sleeping, stomach pain, and weakness. These are not all the possible side effects of EXTAVIA. 21

22 Indication EXTAVIA (interferon beta-1b) is a prescription medicine used to reduce the number of relapses in people with relapsing forms of multiple sclerosis (MS). This includes people who have had their first symptoms of multiple sclerosis and have an MRI consistent with MS. EXTAVIA will not cure MS but may decrease the number of flare-ups of the disease. Important Safety Information Do not take EXTAVIA (interferon beta-1b) if you are allergic to interferon beta-1b, to another interferon beta, to human albumin, or to mannitol. EXTAVIA can cause serious side effects, including: Liver Problems Including Liver Failure. Symptoms of liver problems may include yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting, bruising easily, or bleeding problems. Your healthcare provider will do blood tests to check for these problems while you take EXTAVIA. Serious Allergic Reactions. Serious allergic reactions can happen quickly and may happen after your first dose of EXTAVIA or after you have taken EXTAVIA many times. Symptoms may include difficulty breathing or swallowing, swelling of the mouth or tongue, rash, itching, or skin bumps. Depression or Suicidal Thoughts. Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying, new or worse depression (sinking feeling or sadness), new or worse anxiety (feeling uneasy, nervous, or fearful for no reason), trouble sleeping (insomnia), acting aggressive, being angry, or violent, acting on dangerous impulses, hallucinations, other unusual changes in behavior or mood. Other possible serious side effects with EXTAVIA include: Heart Problems. EXTAVIA may worsen heart problems including congestive heart failure. Symptoms of heart problems may include swollen ankles, shortness of breath, decreased ability to exercise, fast heartbeat, tightness in chest, increased need to urinate at night, not being able to lay flat in bed. 22 Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

23 Important Safety Information (cont d) Injection Site Problems. Serious skin reactions can happen in some people, including areas of severe damage to skin and the tissue below the skin (necrosis). These reactions can happen anywhere you inject EXTAVIA. Symptoms of injection site problems may include swelling, redness, or pain at the injection site, fluid drainage from the injection site, breaks in your skin or blue-black skin discoloration. Change your injection site each time you inject EXTAVIA as it will lessen the chance of you having a serious skin reaction. Avoid injecting EXTAVIA into an area of the skin that is sore, reddened, infected, or has other problems. Flu-like Symptoms. EXTAVIA can cause flu-like symptoms including fever, chills, tiredness, sweating, and muscle aches when you first start to use it. These symptoms may decrease over time. Taking medicines for fever and pain relief on the days you are using EXTAVIA may help decrease these symptoms. Seizures. Some people have had seizures while taking EXTAVIA, including people who have never had seizures before. It is not known if the seizures were related to MS, to EXTAVIA, or to a combination of both. If you have a seizure after taking EXTAVIA call your healthcare provider right away. Blood Problems. You may have a drop in the levels of infectionfighting white blood cells, red blood cells, or cells that help you form blood clots. If drops in levels are severe, they can lessen your ability to fight infections, make you feel tired or sluggish, or cause you to bruise or bleed easily. Risk to Pregnancy: EXTAVIA can harm your unborn baby. EXTAVIA may cause you to lose your baby (miscarry). If you become pregnant while taking EXTAVIA call your healthcare provider right away. You and your healthcare provider should decide if you should continue to take EXTAVIA. Most Common Side Effects: The most common side effects of EXTAVIA include low white blood cell count, increases in your liver enzymes, headache, increase in your muscle tension, pain, rash, problems sleeping, stomach pain, and weakness. These are not all the possible side effects of EXTAVIA. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Tell your healthcare provider about all the medicines you take and your medical conditions. Please see the full Prescribing Information and Medication Guide for additional information and talk to your healthcare provider. 23

24 24 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

25 What Are the Benefits of EXTAVIA? Every patient responds differently to treatment. But treatment with EXTAVIA may be beneficial to you for these reasons: EXTAVIA has been shown to decrease the number of relapses EXTAVIA has been shown to help reduce the risk of having a second episode within 2 years in patients with CIS EXTAVIA has been shown to decrease the number of new MRI lesions and reduce the size of existing MRI lesions In studies of people taking interferon beta-1b, it has been shown that with this therapy you may: Experience a slower rate of relapse Experience fewer episodes of new or worsening symptoms Experience fewer days of moderate and severe relapsing symptoms Important Safety Information Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Tell your healthcare provider about all the medicines you take and your medical conditions. 25

26 Why Is Early Treatment With EXTAVIA Recommended? If you ve had one episode and MRI findings consistent with MS, EXTAVIA can help reduce your risk of having another clinical attack. In patients who have had one episode and whose MRI findings are consistent with MS, EXTAVIA has been shown to reduce the risk of having a second clinical attack within 2 years. Why Consider EXTAVIA? If you re already being treated for a relapsing form of MS and are wondering what other treatment options are available, ask your doctor about EXTAVIA. EXTAVIA has been shown to decrease the number of relapses and has a well-established safety and tolerability profile. 26 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

27 What Are the Most Common Side Effects of EXTAVIA? The most common side effects with EXTAVIA (at least 2% more than placebo) were: Injection site reaction Flu-like symptom complex Excessive fatigue Headache Pain Increased muscle tone Muscle pain Fever Rash Chills Trouble sleeping Incoordination Abdominal pain Decreased white blood cells Tissue swelling Urinary urgency Skin disorder Chest pain Vaginal bleeding Impotence High blood pressure Malaise Enlarged lymph nodes Shortness of breath Increased liver enzymes Injection site necrosis 27

28 How Do I Take EXTAVIA? EXTAVIA is injected under the skin every other day using the EXTAVIA Auto-Injector II or by manual injection. The recommended dose of EXTAVIA is 0.25 mg every other day. Your doctor may start you on a smaller dose of mg and increase your dosage gradually over a 6-week period to 0.25 mg. A few important things to remember about taking EXTAVIA: Do not take EXTAVIA 2 days in a row Always use a new, unopened vial of EXTAVIA and syringe for each injection. Throw away any open, unused medicine. Do not reuse any vials, syringes, or needles Change your injection site each time you inject EXTAVIA. This will help to lessen the chance of a serious skin reaction at the injection site Avoid injecting EXTAVIA into an area of skin that is sore, red, infected, or has other problems 28 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

29 If the idea of injecting yourself causes you some anxiety, you are certainly not alone. Many other people with MS feel the same way. Your doctor or nurse should show you the proper injection technique and help you feel at ease with each step of the process before you try injecting on your own. If you prefer, it s not uncommon to ask a close friend or family member to get training to be able to give you the injections. In addition, the EXTAVIA Auto-Injector II keeps the syringe and needle hidden from view. Important Safety Information Other possible serious side effects with EXTAVIA include: Injection Site Problems. Serious skin reactions can happen in some people, including areas of severe damage to skin and the tissue below the skin (necrosis). These reactions can happen anywhere you inject EXTAVIA. Symptoms of injection site problems may include swelling, redness, or pain at the injection site, fluid drainage from the injection site, breaks in your skin or blue-black skin discoloration. Change your injection site each time you inject EXTAVIA as it will lessen the chance of you having a serious skin reaction. Avoid injecting EXTAVIA into an area of the skin that is sore, reddened, infected, or has other problems. Flu-like Symptoms. EXTAVIA can cause flu-like symptoms including fever, chills, tiredness, sweating, and muscle aches when you first start to use it. These symptoms may decrease over time. Taking medicines for fever and pain relief on the days you are using EXTAVIA may help decrease these symptoms. 29

30 What Support Is Available to Me? If you and your HCP decide that EXTAVIA is the right treatment for you, the EXTAVIA Go Program TM can help you learn how to properly administer your treatment with: One-on-one EXTAVIA injection training with a trained registered nurse, in the comfort of your home Over-the-phone support An instructional video on injecting EXTAVIA that you can keep and refer back to at any time A step-by-step administration guide and helpful tips For more information, visit or call EXTAVIA ( ) 8 AM 9 PM Eastern Time, Monday through Friday* * Excludes public holidays. In the event of an urgent issue after hours, you can leave a message at the call center, and a nurse from the Go Program will return your call within approximately 30 minutes. 30 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

31 How Will I Pay for EXTAVIA? If your doctor prescribes EXTAVIA, you may wonder if your insurance will pay for it. The answer will depend on the details of your individual insurance coverage, but EXTAVIA is reimbursable under most plans. To assist you with your questions about health insurance coverage, a free hotline staffed by Go Program Navigators is available to you. Call EXTAVIA ( ) toll-free for more information. Go Program Navigators can assist you. Even if you don t have insurance, our Go Program Navigators will do their best to assist you in identifying alternative sources of reimbursement that may be available to you. Novartis also offers financial assistance programs to help patients with the cost of their medicines. You ll find more information about these programs on page

32 32 Please see additional Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

33 What Questions Should I Ask My HCP? Partnering with your HCP is essential to making the treatment choice that s right for you. The decision you ll make together about which therapy to begin or switch to involves several considerations, like how effective or convenient your treatment choice will be. Keep in mind that your doctor wants to prescribe the right treatment for you. Everyone is different. So it s really important that you be open with your HCP about your individual lifestyle and that you feel comfortable expressing your particular concerns. Partnering with your HCP by communicating exactly what s on your mind is essential to getting the treatment that s right for you. To help you get a productive conversation started, the next page lists a few examples of the kinds of questions you may want to ask your HCP. Once you read through these, it may trigger additional questions of your own. Important Safety Information Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Tell your healthcare provider about all the medicines you take and your medical conditions. 33

34 Questions to Ask Your HCP About Treating Your MS How effective is this treatment? What are the side effects of this treatment? Does the duration of treatment affect how I respond to side effects? Do I need to have my liver monitored periodically? How much medication will I need, and how often will I need to take it? If you suggest an injectable treatment, are there needle options I should know about? Is an auto-injector an option? What do I need to consider when storing the medicine? How will my medication interact with other drugs I m taking? Why do I need to keep taking my medication, even if I feel okay? I m nervous about having injections. What can I do to ease my anxiety? 34 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

35 the support I need 3 Where Can I Find Support? Where Can I Find Support?

36 What Is the Managing your condition is about more than taking your medication. That s why we ve created the EXTAVIA Go Program a free support program for all EXTAVIA patients. If you have questions or concerns about your treatment with EXTAVIA, the EXTAVIA Go Program is here for you. Whether you need specific answers about EXTAVIA from an EXTAVIA Go Program Navigator, in-home injection training with EXTAVIA, or reimbursement information, the EXTAVIA Go Program is ready to give you the support you need. EXTAVIA Go Program Navigators are here to help. Each Go Program Navigator is specially trained to answer questions you may have, from information on treatment with EXTAVIA to services available to you. If you wish, they can help you find local support programs in your area. You can even request that a Go Program Navigator follow up with you on an ongoing basis to provide encouragement as you move forward with your treatment. Where Can I Find Support? Your family members and loved ones are also welcome to call for support, and to join you on your regular appointment calls. Our Go Program Navigators will be more than happy to answer their questions or concerns. 36 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

37 Ease injection anxiety with personalized injection training. Through the EXTAVIA Go Program, you can receive one-on-one EXTAVIA injection training with an EXTAVIA Field Nurse in the comfort of your own home. Get help with the reimbursement process for EXTAVIA. From Day 1, you ll have an experienced Go Program Navigator on your side who will help determine your personal coverage. Getting started is easy. All you have to do is fill out a Service Request Form with your HCP. We re happy to answer any questions you may have about the EXTAVIA Go Program just call EXTAVIA ( ). For more information, visit or call EXTAVIA ( ) 8 AM 9 PM Eastern Time, Monday through Friday* * Excludes public holidays. In the event of an urgent issue after hours, you can leave a message at the call center, and a nurse from the Go Program will return your call within approximately 30 minutes. 37

38 Can You Help With My Prescription Costs? If you are worried about the cost of your medicine, we have programs that may be able to help. The majority of patients are eligible for a $0 co-pay with the EXTAVIA Co-Pay Support Program from Novartis. Out-of-pocket costs are covered up to [$9,300] per year. This co-pay program is available for eligible EXTAVIA patients, regardless of income level or medical history. Not all patients will receive a [$9,300] annual benefit. The amount that Novartis will cover depends on your applicable out-of-pocket costs for EXTAVIA.* The Novartis Patient Assistance Program (PAP) provides free medicine to low-income, uninsured patients. If you are in financial need, Novartis is committed to providing access to EXTAVIA. To qualify, you must be a US resident, receive an income less than 500% of the Federal Poverty Level, and must not have insurance (public or private) or any third-party prescription coverage. If you qualify for the Novartis PAP, your EXTAVIA prescriptions will be shipped directly to your home. For more information, visit or call EXTAVIA ( ). * The EXTAVIA Co-Pay Support Program offer is not valid for prescriptions for which payment may be made in whole or in part under federal or state health programs, including but not limited to Medicare or Medicaid. Limitations apply. The program is subject to termination or modification at any time. You are required to report any benefits you receive under the EXTAVIA Co-Pay Support Program to your insurance company. 38 Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

39 Where Else Can I Find Support? We understand that there s a larger conversation happening about MS beyond the EXTAVIA Go Program. Although we strive to bring you information that is insightful and useful, we know the story does not end here. That s why the EXTAVIA Go Program is dedicated to connecting you with information, organizations, and services that are popular with and relevant to your peers. On the following pages are selected third-party organizations dedicated to helping people whose lives are affected by MS. These organizations are independent from Novartis Pharmaceuticals Corporation. 39

40 NATIONAL MULTIPLE SCLEROSIS SOCIETY The National Multiple Sclerosis Society (NMSS) is a collective of passionate individuals who want to do something about MS now to move together toward a world free of MS. The NMSS provides information about MS, treatment, research, MS-related events, and more. You can search its Web site for a local chapter in your area. MULTIPLE SCLEROSIS FOUNDATION The Multiple Sclerosis Foundation (MSF) is a predominantly service-based, nonprofit organization. The MSF provides a comprehensive approach to helping people with MS maintain both their health and well-being. The organization s programming and support are designed to keep people with MS self-sufficient and their homes safe, while its educational programs heighten public awareness and promote understanding about the illness. MULTIPLE SCLEROSIS ASSOCIATION OF AMERICA The Multiple Sclerosis Association of America s (MSAA) mission is to enrich the quality of life for everyone affected by MS. Its wide array of programs and services bring ongoing support and direct services to people with MS and their families throughout the country. MSAA also serves to promote greater understanding of MS and the diverse needs and challenges of people with MS Please see Important Safety Information on pages 22 and 23. Please see accompanying full Prescribing Information, including Medication Guide, in the pocket.

41 CAN DO MULTIPLE SCLEROSIS Can Do Multiple Sclerosis, formerly the Heuga Center, is a nonprofit organization offering MS programs based on the philosophy that a person can have a chronic disease and also maintain their health. Programs include education, nutrition, mental well-being, and exercise, as well as learning specific, individualized life management skills and ways to integrate wellness activities into everyday life. You can search for local events and apply for programs on its Web site. MSWORLD MSWorld is a global online community dedicated to ending the isolation that people feel when diagnosed with MS. Offering chats, message boards, a resource center, and an online magazine, MSWorld aims to provide a safe, informative, and fun place for people with MS to meet, share ideas, and gain useful resources to keep them moving forward while living with MS. ACCELERATED CURE PROJECT FOR MULTIPLE SCLEROSIS The Accelerated Cure Project for Multiple Sclerosis (ACPMS) is a national nonprofit dedicated to curing MS by determining its causes. The project is focused primarily on a research effort to find the causes of MS. ACPMS also provides daily updates on MS research, creates a quarterly print newsletter, and hosts a variety of social and educational events throughout the year. These organizations are independent from Novartis Pharmaceuticals Corporation. 41

42 EXTAVIA is a registered trademark of Novartis AG. GO PROGRAM is a trademark of Novartis AG. Novartis Pharmaceuticals Corporation East Hanover, New Jersey Novartis Printed in USA 1/15 EXD