Centro de Investigación Biomédica En Red de Salud Mental

Transcription

1 2010 ANNUAL REPORT

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3 Centro de Investigación Biomédica En Red de Salud Mental Unión Europea Instituto de Salud Carlos III Fondo Europeo de Desarrollo Regional Una manera de hacer Europa

4 INDEX Presentation...5 Introduction... 6 CIBERSAM Innovation... 9 Internal Organization Scientific Activity Calls and Projects...18 Transversal Areas Figures and News...45 CIBERSAM in figures CIBERSAM in the News Research Areas Depression Schizophrenia Bipolar Disorder Other Mentals Disorders Groups Centro de Investigación Biomédica En Red de Salud Mental

5 PRESENTATION Introduction...5 CIBERSAM Innovation...9 Internal Organization... 10

6 2010 ANNUAL REPORT Introduction Three years after its establishment, the Mental Health CIBER (CIBERSAM) has largely attained the objectives set at the beginning of our project s course. This annual report shows how in a short period of time we have succeeded in that the main mental health research groups of our country participate in joint objectives. It also bears witness to the fact that, apart from a national collaboration between clinical and basic groups, the common effort has resulted in our internationalization via the cooperation with other European mental health networks, especially through initiatives funded by the 7th Framework Programme. In 2010, we have changed our working strategy per areas to a set of pathology programmes, enhancing and adding cross areas. This means that, although the groups carry out research not directly embedded in the CIBER s mission, only the collaborative elements, those that take advantage from CIBERSAM s structure, will be fostered. In the 2011 annual strategy, we go on identifying evaluable indicators for each one of the areas, platforms, joint projects and training, all of them being more and more ambitious in spite of the economic context and the granted funds. Some platforms have steadied themselves, as for instance the Bank of Instruments, which is providing a good service to the intramural and extramural scientific community, and the DNA platform, which is gathering a considerable amount of samples and this makes us highly competitive among international consortia. The GRIDSAM tool, which allows entering data in multiple centre projects, has been transformed into a grid system that makes a centralized capture of data, allowing thus a more efficient data mining. This system is already being used in multiple centre projects and allows the researchers to have an easier access to an important amount of data. It not only facilitates the data management, but also can be used to carry out concept tests that later on can be checked through studies designed for those purposes. We are particularly proud of our increasingly prolific participation in European projects within programmes such as the 7th Framework Programme, DG-SANCO, Marie Curie, IMI, among others. This year we have obtained several projects of the ERANET-Neuron mental health call. After having impelled the Madrid Statement, available in our website ( and in our 2009 annual report, we have succeeded in having the European Commission launch a call to elaborate the European Mental Health Road Map, with the aim to integrate and coordinate the research done on this field in all the European Union countries. By the time we were preparing this annual report, we have been informed that the CIBERSAM-led consortium, directed by Josep Maria Haro, has been chosen to carry out that road map for the next three years. Due to its extremely strategic importance, this excellent news represents the best European project granting, since the Road Map will determine the priority and financing lines of the European Commission concerning mental health in the years to come. Our coordinator of European programmes, José Luis Ayuso, has played a key role in the achievements of this area. 6

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8 2010 ANNUAL REPORT Being aware of the need to communicate our findings to society, one of the cross areas that we have fostered is the institutional relations and communication area, to which Dr. Miquel Bernardo has been appointed. During 2010, we have intensified our relationship with families and patients associations. We organized the CIBERSAM Social Forum, which gathered the most relevant associations of families and patients along with CIBERSAM researchers. In this meeting we had the opportunity to explain CIBERSAM s activities and to have a first-hand report by the associations about the perceived needs and areas to be improved in mental health research. In 2010, CIBERSAM frequently appeared in the media. We have constantly improved our website so as to make it more intuitive and to provide the users, network members as well as CIBERSAM outsiders, with more information. As for the management area, the quality accreditation has been renewed for all administrative procedures in purchasing and staff management. Moreover, we have improved a software allowing the people in charge of administration to do a non-centralized management of the groups projects and budgets, with real time monitoring and limiting the use of paper only to legally compulsive cases. Likewise, this software facilitates the automated elaboration of annual reports as well as the annual evaluation of the CIBERSAM groups. It is evident that there are many challenges ahead and that the current context, with its budget limitations, makes it difficult to keep the cruising speed we had up to now. In spite of the decreasing public funding, we will only be able to progress with a higher efficiency in the scientific management of the granted funds. We must also actively look for other funding resources. This was an attained objective in 2010 due to the agreements reached with different private companies. Finally, we can only have a stable research structure through a dynamic model, away from the public research centre classic model of our country. For this purpose, it is necessary to facilitate, on the one hand, that the less productive groups and with a lesser added value to CIBER leave the consortium and, on the other hand, that those outside groups having enough credentials and willing to become members be included in our institution. The current economic crisis must strengthen us and we must turn this budget decrease into an opportunity to increase our efficiency, excellence, and alternative fund raising. It is only in this way that we will be able to keep the splendid cruising speed attained during our first three years. With no vertigo. Celso Arango López Scientific Director 8

9 Innovation in Cibersam Nowadays, the word innovation has become a magic word about which everybody wants to talk. In our field, it basically stands for the process that allows translating the object of our research into a genuine knowledge that brings improvements in the clinical practice and, therefore, in the mental health of our society and its citizens. With this view, in CIBERSAM we try to promote an innovation culture in all research areas. A good example would be the creation of a new programme of therapeutic innovation in which a large number of groups participates. This innovation process must be continuous. This continuity has allowed our institution to become a national reference in the short term and to transcend now to an international level. The creation or modification of useful products for society is directly connected to the mission and the perspective of our CIBER. In this Annual Report, at the end of each research group record, the main innovative contributions in 2010 are presented. CIBERSAM aims to generate a translation between clinic and knowledge fields such as Neuropharmacology, Genetics, Imaging, Epidemiology or Biochemistry, which results in a better understanding of mental disorders. In order to achieve this, we are totally aware that we must make a symbiosis with the private business sector. In line with this, since the consortium was created, 17 agreements have been reached between CIBERSAM and private companies. Innovation, transmission, and transference in relation with products as well as with processes as in the new therapeutic targets with a specific programme in our CIBER since 2010 are elements that must focus not only on searching molecules with new action mechanisms, but also on searching new diagnosis, detection, assessment and prognosis techniques, non pharmacologic therapeutic approaches or imaging technology. An example of all this would be the participation of CIBERSAM groups, for instance Dr. Artiga s, in the European initiative IMI to develop new therapeutic targets. This project is half sponsored by private companies and by the European Commission. The combination public-private sector is the most efficient way to turn ideas into patents and to obtain funds from the research that has been carried out. This is the philosophy of other countries that have increased their research budget, even in a situation of economical crisis, since they are convinced that this is the only way to generate wealth in the medium term. In 2010, the CIBERSAM groups achieved 5 patents, they did 53 clinical trials, and participated in 13 clinical guides. We are committed in going on innovating with the ultimate aim of having the feeling of being more useful to society and, thus, of doing what we really like. 9

10 2010 ANNUAL REPORT Internal Organization CIBERSAM, in accordance with its statutes, is governed and administered by the Board of Trustees and its Permanent Commission and the following managerial bodies: the Steering Committee, the Scientific Director, and the Management. The coordinating structure of CIBERSAM is set up to guarantee that it functions efficiently and facilitates the achievement of its planned goals. Such structure is divided into a scientific line and an economicadministrative line. Organization Chart: BOARD OF TRUSTEES SCIENTIFIC COUNCIL PERMANENT COMMISSION SCIENTIFIC DIRECTOR MANAGEMENT STEERING COMMITTE TECHNICAL UNIT AREA COORDINATOR TRAINING & MOBILITY COORDINATOR EUROPEAN PROGRAMMES COORDINATOR INSTITUTIONALS RELATIONS COORDINATOR QUALITY & INTERNAL EVALUATION COORDINATOR RESULTS & COMUNICATIONS COORDINATOR DATABASES COORDINATOR PLATFORMS COORDINATOR During the meeting of the Steering Committee held on August 2, 2010, the committee unanimously approved the replacement of Jerónimo Saiz by Miguel Bernardo Arroyo as Institutional Relations Coordinator. 10

11 Board of Trustees The Board of Trustees consists of three representatives from the Instituto de Salud Carlos III and a representative from each of the Consortium Institutions. The President of the Board of Trustees is the Director of the Instituto de Salud Carlos III and the Managing Director of the Consortium acts as the Secretary of the Board. The Board of Trustees exercises general control over the Consortium; it designates and appoints the members of the Scientific Council, the Permanent Commission and the Scientific Director of CIBERSAM. Members of the Board of Trustees: Instituto de Salud Carlos III: Jerónimo Navas Palacios (Presidente del Consejo) Instituto de Salud Carlos III: Joaquín Arenas Barbero (Vicepresidente del Consejo) Instituto de Salud Carlos III: Miguel A. Cabo López Cibersam. Managing Director: Manuel Sánchez Delgado (Secretario del Consejo) Cibersam. Scientific Director: Celso Arango López Consejo Superior de Investigaciones Científicas: Paola Bovolenta Nicolao Fundación IDIBELL: Emilià Pola Robles Fundación Hospital Universitario Marqués de Valdecilla: Luis Carmelo Anchoriz Tejedor Fundación para la Investigación Docencia Sant Joan de Deu: Emili Bargallo Angerri Fundación Vasca de Innovación e Investigación Sanitarias: Carmen Garaizar Axpe Hermanas Hospitalarias Sagrado Corazón de Jesús - Benito Menni: Josep Treserra Torres Hospital Clínico y Provincial de Barcelona: Ramón Gomis de Barabara Instituto Aragonés de Ciencias de la Salud: Esteban de Manuel Keenoy Instituto de Investigación Hospital Santa Cruz y San Pablo: Jaume Kulisevsky Servicio Madrileño de Salud: Elena Andradas Aragonés Universidad Complutense de Madrid: Milagros Palacios Alarcón Universidad de Barcelona: Xavier Meneses Martínez Universidad de Cádiz: Francisco Antonio Macías Domínguez Universidad de Cantabria: José Carlos Gómez Sal Universidad de Granada: María Dolores Suárez Ortega Universidad de Oviedo: Santiago García Granda Universidad de Valencia: Ana María Cortés Herreros Universidad del País Vasco: Antonio Romo Soler 11

12 2010 ANNUAL REPORT Permanent Commission The Permanent Commission is comprised of the President of the Board of Trustees, the Scientific Director of the Consortium, the Managing Director of the Consortium, who acts as Secretary, and four representatives of the Consortium Institutions. The Permanent Commission evaluates the activities of the Consortium and reviews and adjusts budgets, accounts and other reports to be approved by the Board of Trustees. Members of the Permanent Commission CIBERSAM. Managing Director: CIBERSAM. Scientific Director: Fundación para la Investigación y Docencia Sant Joan de Deu: Fundación Vasca de Innovación e Investigación Sanitarias: Instituto de Salud Carlos III: : Universidad de Granada: Universidad de Oviedo: Manuel Sánchez Delgado (Secretario) Celso Arango López Emili Bargallo Angerri Carmen Garaizar Axpe Joaquín Arenas Barbero María Dolores Suárez Ortega Santiago García Granda 12

13 External Scientific Advisory Committee This committee provides general scientific advice and support to the Board of Trustees. Its members are composed of international caliber scientists in the field of health services whose distinguished professional or scientific careers are especially relevant to the objectives of CIBERSAM. The committee has a President and at least four additional members, all of them appointed by the President of the Board of Trustees. The External Scientific Advisory Committee informs and advises the Board of Trustees on the characteristics of scientific and technical research occurring at national and international levels and on its possible impact on the operation of CIBERSAM. Its main functions are: Advising with respect to scientific policy guidelines and institutional relationships Reviewing the proposed Strategic Plan, the proposed Annual Scientific Reports, and the Annual Action Plans Reporting on the adequacy of programs, resources, and capabilities for the purposes of the consortium Advising on the strategy of transferring research results Advising on the policy relating to scientific staff incorporation Reporting on the creation of research programs MEMBERS INSTITUTION POSITION Jim Van Os Guy Goodwin Michael Hamon María Ron Marion Leboyer Maastricht University, Holland Department of Psychiatry, University Of Oxford, Warneford Hospital, Oxford, United Kingdom Institut National de la Santé et de la Recherchev Médicale/Université Pierre et Marie Curie. Paris, France Institute of Neurology, University College London, Queen Square, London, United Kingdom Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, Paris, France President of the External Scientific Comiitee Member Member Member Member 13

14 2010 ANNUAL REPORT Steering Committee The Steering Committee of CIBERSAM is the body responsible for carrying out managerial tasks. It is a collegiate body that ensures the development of CIBERSAM, meeting the needs of its member groups and their strategic objectives. Members of the Steering Committee: Dr. Celso Arango Dr. Francesc Artigas Dr. Victor Pérez Dr. Eduard Vieta Dr. Julio Sanjuán Dr. Antonio Lobo Dr. Ángel Pazos Dr. Josep María Haro Dra. Ana María González-Pinto Dr. Manuel Sánchez Scientific Director Coordinator of the Depression Area Coordinator of the Bipolar Disorder Area Coordinator of Schizophrenia Area and Common Databases Coordinator of Other Mental Disorders Area Coordinator of Training and Mobility Coordinator of Platforms Quality Coordinator Managing Director Technical Unit The headquarters of CIBERSAM s Technical Unit are in Madrid, at 46 Doctor Esquerdo Street, in the Gregorio Marañón Hospital, Government Pavillion, 1st floor. Its mission tasks include an appropriate staff management, payments to vendors, project coordination, diffusion and communication, asset management, administrative hiring, negotiation of agreements, and lastly, the facilitation of dialogue among the geographically dispersed research groups and the administrative bodies of CIBERSAM. Manuel Sánchez Delgado Begoña Sáenz de Tejada Paula López Amaya Rivera Algarrada Sara García Rodríguez Elena Cortés Leclerc María Miret García Managing Director Technical Unit Administration Human Resources European Projects - Communication Scientific Secretary Communication* *Dropped out on September 15th,

15 Cibersam Consortium Eight Autonomous Regions taking part through the following institutions and/or centres Funded by: Unión Europea Fondo Europeo de Desarrollo Regional Una manera de hacer Europa 15

16 2010 ANNUAL REPORT Cibersam Groups principal investigator institution city code área Dr. Celso Arango López Hospital General Universitario Madrid G01 Other mental Gregorio Marañón disorders Dr. Francesc Artigas Pérez Instituto de Investigaciones Biomédicas Barcelona G02 Depression Dr. Jose Luis Ayuso Mateos Hospital Universitario La Princesa Madrid G03 Bipolar disorder Dr. Miquel Bernardo Arroyo Hospital Clínic i Universitari de Barcelona Barcelona G04 Schizophrenia Dr. Julio Bobes García Universidad de Oviedo Oviedo G05 Bipolar disorder Dr. Jorge A. Cervilla Ballesteros Universidad de Granada Granada G06 Depression Dr. Manuel Desco Menéndez Hospital General Universitario Madrid G07 Schizophrenia Gregorio Marañón Dra. Lourdes Fañanás Saura Universidad de Barcelona Barcelona G08 Depression Dr. Javier Garzón Niño Instituto Cajal, CSIC Madrid G09 Depression Dra. Ana Mª. Glez-Pinto Arrillaga Hospital Santiago Apóstol Vitoria G10 Bipolar disorder Dr. Josep M. Haro Abad Fundació Sant Joan de Déu Barcelona G11 Schizophrenia Dr. Juan Carlos Leza Cerro Universidad Complutense Madrid G12 Other mental disorders Dr. Antonio Lobo Satué Hospital Clínico Universitario Zaragoza G13 Other mental disorders Dr. Juan José López-Ibor Aliño Hospital Clínico San Carlos Madrid G14 Other mental disorders Dr. Peter McKenna Benito Menni Complex Assistencial Barcelona G15 Schizophrenia Dr. Javier Meana Martínez Universidad del País Vasco Leioa, G16 Depression Bizkaia Dr. José Manuel Menchón Magriñá Hospital Universitari de Bellvitge Barcelona G17 Other mental disorders Dr. Juan Antonio Micó Segura Universidad de Cádiz Cádiz G18 Bipolar disorder Dr. Tomás Palomo Álvarez Hospital Universitario 12 de Octubre Madrid G19 Schizophrenia Dr. Ángel A. Pazos Carro Universidad de Santander Santander G20 Depression Dr. Víctor Pérez Solá Hospital de la Santa Creu i Sant Pau Barcelona G21 Depression Dr. Jerónimo Sáiz Ruiz Hospital Universitario Ramón y Cajal Madrid G22 Other mental disorders Dr. Julio Sanjuán Arias Universidad de Valencia Valencia G23 Schizophrenia Dr. Rafael Tabarés Seisdedos Universidad de Valencia Valencia G24 Bipolar disorder Dr. Eduard Vieta Pascual Hospital Clínic i Universitari de Barcelona Barcelona G25 Bipolar disorder Dr. José Luis Vázquez-Barquero Hospital Universitario Marqués de Valdecilla Santander G26 Schizophrenia 16

17 scientific ACTIVITY Calls and Projects Transversal Areas

18 2010 ANNUAL REPORT Calls and Projects Among the activities developed by CIBERSAM, there are innovation initiatives that contribute to carrying out a quality research. In this area, it is noteworthy the launch of funding calls for coordinated projects fostering cooperation between the consortium groups. In 2010, the following internal calls were carried out: Intensification Call, Translational Intramural Call, Funding call to develop projects within the Neuroimaging Platform, Call of grants for the Bank of Instruments research projects. Intensification Call This call, approved in CIBERSAM s annual meeting held on October 24th 2009, finances up to 36 months/year. It was published on October 27th 2009 and its aim is to free the researcher or the scholar from the assistance workload. According to the resolution published on December 9th 2009, the list of intensified CIBERSAM researchers for the year 2010 is as follows: Dr. Celso Arango López Dra. Lourdes Fañanás Saura Dr. Víctor Pérez Sola 18

19 Translational Intramural Call Always within the frame of development and support to scientific activities, CIBERSAM has agreed to finance intramural projects of clinical and translational nature. The funds are used as a complement to projects financed by public institutions in competitive calls as well as for projects specifically addressed to this call, without complementary fundings. In CIBERSAM, the studies on mental health aim to lead a translational tendency that allows innovative results. The innovative, translational, and collaborative nature of the project to be developed is one of the valued aspects when selecting projects. In this context, 16 projects were submitted to the translational intramural call on September 23rd All the projects had high quality standards and 6 of them were granted funds for the year 2011 (resolution on December 28th 2010). Resolution to the translational intramural projects call: Project MR GROUPS Granted amount Use of antidepressants in the last decade and its relation to mortality and suicide-related events, with special focus on children and adolescents JL Ayuso G03-G01-G21 55,000 Metylphenidate immediate release in the initial treatment of symptoms of acute mania JL Ayuso G03-G5-G21 53,000 Cortical activity in schizophrenia: a translational study on the pharmacological response to hallucinations. J. Sanjuán G23-G02-G21-G15 39,000 Metabotropic glutamate receptors 2/3 (mglur2/3) as drug targets to improve cognitive impairment in schizophrenia. F. Artigas (A. Castañé) G02-G20 39,000 Depression and chronic pain comorbidity: impact on neurogenesis and cognition. JA Micó G18-G12-G07-G09 43,000 Study of gene-environment interactions in schizophrenia: vulnerability and severity. C. Arango G01-G04-G23-G05 74,000 19

20 2010 ANNUAL REPORT Funding call to develop projects within the Neuroimaging Platform With the aim to promote the development and application of quantitative analysis techniques in Neuroimaging within CIBERSAM, the Neuroimaging Platform received a 63,000 grant to finance research projects throughout This call is addressed to all CIBERSAM groups. The projects can be jointly done by several research teams and, in general, the multiple centre (multiple group) nature is highly valued. The participation of external groups is also taken into consideration if at least one of the participants and the coordinating group belong to CIBERSAM. The projects must fit into the working lines that are of interest for the whole CIBERSAM. The projects orientation must be technical, methodological, and eminently practical, focused on the development, implementation, and validation of analysis and image processing techniques applicable to neurobiological research. Four out of five projects were funded with the call published on October 6th The resolution of the 2010 call of the Neuroimaging Platform took place on December 21st

21 Title Research team Granted funds Comparative analysis of segmentation tools for the estimation of sulcal depth in brain MR images Validation and Implementation of Morphomety technique based on sources for its application in the field of mental diseases Software programming to calculate connectivity maps at voxel level using the spectrum measurements and minimizing the physiological noise Development of a software tool for the automated processing of SPM studies on fmri in animals and for the adaptation of non-linear and multiple variable methods in SPM studies. IP J Janssen G01 E Canales G15 R Salvador G15 Y Alemán G07 S Reig G07 IP G Monté Rubio G15 E Canales G15 P Salgado G15 E Pomarol G15 P McKenna G15 J Sanjuán G23 G García-Martí G23 V Iglesia G23 IP R Salvador G15 E Canales G15 M Anguera G15 S Reig G07 Y Aleman G07 IP E Berrocoso G18 JA Micó G18 S Torres G18 M Desco G07 Y Aleman G07 M Soto-Montenegro G07 C Chavarrías G07 M Benito G07 M Martínez UC3M V Gómez UC3M M Cassía UC3M 17,500 4,900 19,600 21,000 21

22 2010 ANNUAL REPORT Call of grants for the Bank of Instruments research projects On the 28th September 2010, CIBERSAM launched the financing call for research projects in the Bank of Instruments (BICIBERSAM). The research projects liable to receive grants must be within some of the following working lines developed by BICIBERSAM: Instruments for diagnosis evaluation. Instruments for symptomatology evaluation. Instruments for neuropsychology evaluation. Instruments for disability assessment. Specific instruments to be applied to childhood/adolescence. Specific instruments to be applied to special populations. Instruments for dual pathology assessement. 22

23 This call s resolution was published on December 22nd The following 9 projects, out of 31, received funds for 2011: TITLE Researcher Group Validation of the Bermond-Vorst alexithymia questionnaire for Spanish population with severe mental disorder Ana González-Pinto G10 Factorial structure, convergent validity, discrimination capacity and change sensitivity in the Spanish version of the Remission from Depression Questionnaire (RDQ) Víctor Pérez Sola G21 Relation between the psychometric evaluation of psychosocial performance and quality of life in euthymic bipolar patients Eduard Vieta G25 Evaluation of change sensitivity in a psychosocial performance scale in bipolar patients (FAST) Eduard Vieta G25 Creation of a screening test for cognitive deterioration in alcoholism Gabriel Rubio Valladolid G19 Development of a new scale for dementia stages: practicability, reliability, and validity Antonio Lobo G13 Validation of the self-injurious thoughts and behaviours interview (SITBI) in Spanish population with suicidal conduct Enrique Baca García G22 Study on the creation and validation, for the Spanish population, of a scale to measure the degree of severity of drugs consumption in dual pathology patients Iris Baños Yeste G11 Spanish validation of a series of films to induce emotions Enrique Álvarez Martínez G21 23

24 2010 ANNUAL REPORT Transversal Areas Transversal Areas are tools that allow approaching the objectives planned in CIBERSAM. These areas were created drawing from the REM-TAP experience, at the origin of the Mental Health CIBER, with a view to empower the research groups that shape this network centre by providing them with more means, by facilitating the accessibility and by fostering their collaboration. Transversal AREAS Training and Mobility European Programmes and International Relations Institutional Relations Quality and Internal Evaluation Results and Communication Common Data Bases Platforms AREA coordinator Dr. Ángel Pazos Carro (G20) Dr. José Luis Ayuso Mateos (G03) Dr. Jerónimo Saiz (G22) * Dr. Miquel Bernardo (G04) Dra. Ana González-Pinto (G10) Dr. Julio Bobes García (G05) Dr. Juan Antonio Micó Segura (G18) Dr. Julio Sanjúan Arias (G23) Dr. Josep Mª Haro Abad (G11) * The Steering Committee, at the meeting held on the 2nd August 2010, unanimously approved that Miquel Bernardo should substitute Jerónimo Saiz as Coordinator of Institutional Relations. 24

25 Training and Mobility One of the objectives of CIBER of Mental Health is to improve the training of mental health researchers in this country. It is a necessary goal if we want to have well-trained professionals in the field of Mental Health and the Neurosciences. We at CIBERSAM believe that the training, especially of young researchers, is a strategic investment. Accordingly, since the start of the network centre, a training programme has been organized that seeks to be a reference for training in Mental Health in this country. Ángel Pazos Carro Coordinator of Training and Mobility Area Training Programme Objectives One of the missions of CIBERSAM is to facilitate and improve the training capacity of its researchers. For this reason, CIBER of Mental Health provides, within its work strategies, a specific training programme aimed preferentially towards trainee researchers. 80% of the total Training budget and at least 70% of each group s budget must be devoted to priority courses and internships or placements with other CIBERs. The training programme includes the following priority objectives: Facilitate the training of young researchers and their access to new scientific and technological knowledge related to research. Enhance training activities, preferably in the strategic lines defined in the basic project of CIBERSAM. Contribute to the integration of all the groups of CIBER as per its structure. Identify new needs with respect to the in-house training of the CIBERSAM professionals which should be incorporated into the programme. Training Programme Activities In 2010, the following activities were completed as part of the training programme: Training courses which are related to various research areas of CIBER or which are of a more general character. In accordance with the funding rules and the approved prioritization for 2010, the training programme funded: As a first priority, programmes and courses offered by CIBERSAM itself, organized by its member groups or those others identified as of special interest. The course offerings are listed on the CIBERSAM website throughout the year. 25

26 2010 ANNUAL REPORT As a second priority, attendance at other courses related to subjects that the Programme has identified as of interest as they are subject matters which are in high demand by a significant part of the member groups: Applied Statistics for Medicine, Data Analysis and the Use of Specific Software, Research Methodology, Cognitive Therapy, Statistical Parametric Mapping (SPM), Approved Courses on the Handling Animals for Scientific Research and Courses for Operators or Supervisors of Radioactive Installation. Research Placements: in accordance with the funding rules approved in 2010, the Programme financed placements in other units of CIBER (hospitals, laboratories, specific units) or placements abroad for the purpose of learning techniques, instruments, strategic and diagnostic therapies, new approaches, etc. Curriculum Development and the corresponding Report regarding the development of CIBER s own Master and Postgraduate Studies in Mental Health Research. As discussed further below, in 2010, CIBERSAM designed a Studies Programme, selecting the participating Universities and establishing the performance standards, etc. Each of the Universities has begun the approval process. Training Courses With regard to the courses that were offered, the Programme established the following as priority courses: Courses organized by CIBERSAM itself: Jornada de Bancos de Tejidos Neurológicos y Salud Mental, Barcelona (Dr. Josep Mª Haro) Curso sobre Validación de cuestionarios, Barcelona (Dr. Josep Mª Haro) Curso intensivo de introducción a la investigación básica en Neurociencias, Madrid, (Dra. Lourdes Fañanás) Evaluación y Tratamiento de las alucinaciones auditivas en las Psicosis, Valencia, (Dr. Julio Sanjuán) Laboratorio de Ideas del CIBERSAM: Reunión semestral de presentación y discusión de resultados de investigación, Madrid (Dres. Juan C. Leza y Rafael Tabares) Introducción a la psicopatología y diagnóstico de la enfermedad mental, Barcelona (Dra. Lourdes Fañanás) 26

27 Courses led by researchers of CIBERSAM and offered by the Programme 23 Courses were offered by 11 groups. The website of CIBERSAM provides the complete listing ( Courses deemed to be of general high interest Máster de investigación en Metodología de la investigación: Diseño y Estadística en Ciencias de la Salud, UAB. Scientific placements With respect to placements, in 2010, 33 placements were offered by 12 groups of CIBERSAM. Master of Mental Health Research The Committee selected by the Steering Committee for the formal establishment of the proposed Master had three meetings (one in Madrid and two in Barcelona) and multiple contacts via and teleconference. It also contacted the Lilly Foundation with the view of a possible collaboration in the delivery of these studies. The result of this work is the corresponding Report, whose most important findings are: An inter-university structure, with participation from the Universities of Cantabria (coordinator), Autónoma of Barcelona, Barcelona, Cádiz and Complutense of Madrid 60 credits, of which 34 are required (and 24 are of a practice nature); 6 credits which are required for the Master s Thesis; 4 modules, in addition to the work for the Master s Thesis. - Basic (2 content areas and 3 subjects) - Fundamental Issues in Mental Health Research (2 content areas and 7 subjects) - Biological and Therapeutic Basis of Mental Illness (3 content areas and 7 subjects) - Clinical Research Issues in Mental Health (4 content areas and 10 subjects) During 2010, this proposal was approved by the universities of Cádiz and Cantabria. The process should culminate in 2011 with the approval by the remaining Universities, the obligatory review of ANECA and its implementation. 27

28 2010 ANNUAL REPORT Funded Activities Attendance in 68 courses by members of CIBERSAM was funded: of which, 65 were in Spain and the remaining 3 were abroad. Of those which took place in Spain, 36 were courses organized by CIBER or directed and offered by its groups. The remaining courses were on the subject matters mentioned above. The percentage of participation in courses offered by CIBER vis-à-vis the total participation in all courses financed by the Programme was 52.9%, as compared to 9% in 2009, resulting in the successful achievement of one of the indicators of the Programme (an increase in 10%). Members of CIBERSAM enrolled, under the Training Programme, in 8 courses offered/directed by group members, as compared to 3 in placements for members of CIBERSAM were funded for a total time period of 7.2 weeks. Four of these placements were in Spain and the rest were abroad. All the placements which took place in Spain were offered by the groups of CIBERSAM. The subject matters encompassed the spectrum referred to above. The percentage of placement weeks with the CIBER groups vis-à-vis the total placements funded by the Programme was 61.1%, as compared to 15% in 2009, resulting in the achievement of one of the indicators of the Programme (increase in 10%). Lastly, CIBERSAM financed the expenses resulting from the meeting of the members of the Commission tasked with the establishment of the Master s Programme in Mental Health Research that took place in Madrid in january

29 European Programmes The aim of CIBERSAM is to become an internationally prestigious organization in the field of mental diseases. For this reason, one of our stated objectives is to ensure that the research groups that conform this CIBER will also contribute to the research projects of other well known European and international centres. In this sense, the aim of the European Programmes area is to give support to those research groups willing to engage themselves with those initiatives. Another purpose of this programme is to grant CIBERSAM s participation in the coordination activities of the national European networks already existing and to keep in contact with the European Commission institutions relevant to the funding of research in Mental Health, all of this with the aim of fostering the creation of calls in the areas in which CIBERSAM is interested. Dr. José Luis Ayuso Mateos Coordinator of the European Programmes and International Relationships Area Throughout 2010 several european projects were launched in which take part the CIBERSAM groups: PERS Paediatric European Risperidone Studies. MRs: IPs Arango (G01) and Castro (G04). OPTIMISE Optimization of Treatment In the Management in Schizophrenia in Europe. MR: Arango (G01) and three CIBERSAM groups subcontracted. EUGEI European Joint National Schizophrenia Networks for the Identification of Gene- Environment Interactions. MR: Arango (G01) and three CIBERSAM groups subcontracted. Working in Europe to Stop Truancy Among Youth. MR: Bobes (G05). PARADISE Psychosocial factors Relevant to brain DISorders in Europe. MR: Ayuso (G03). European Friedreich s Ataxia Consortium for Translational Studies. Contributor: Maria Dolores Moltó Ruiz (G23 appointed member). Implementing a Scientific International master for biotechnology and neuroscience in the South Mediterranean area. Education, Audiovisual and Culture Executive Agency. ontributor: Julio Sanjuán Arias (G23). 29

30 2010 ANNUAL REPORT Moreover, the following european projects with participation of CIBERSAM groups have been approved: Suicidality: Treatment Occurring in Paediatrics (STOP). 4th Call for Proposals HEALTH : Participants: G01 (C. Arango), G04 (Castro) (CIBERSAM Economic management) Paediatric European Risperidone Studies. Small or Medium-scale Focused Research Project: 4th Call for Proposals HEALTH : G01 (C. Arango), IP Castro (G04) Memory, concentration and planning abilities in schizophrenia: A comparison of two assessment packages. Call WPO3 -Development of cognitive measures ideal for international trials and back- translation to preclinical models. NEWMEDS - Innovative Medicine Initiative (IMI). G01 (C. Arango). Supporting prevention and control of non-communicable diseases in developing countries. EuropeAid Global Calls (EuropeAid/129197/C/ACT/Multi). G03 (J. L. Ayuso) Global information system on the Higher Education Institutions of Latin America for a Higher Education Common Area with Europe. Call Alfa III-European Commission. G23 (Jose Miguel Carot Sierra) From autism to schizophrenia: study on the genetic mechanisms underlying brain dysfunction and structural phenotypes in schizophrenia and autistic spectrum disorders. NEURON-ERANET NEURON Joint Call 2010 European Research Projects on Mental Disorders. G08 (L. Fañanas L). G01 (M. Parellada) DBS-F20rat Describing pathophysiology to promote focal therapy in treatment of schizophrenia an animal experimental study. NEURON-ERANET, Joint Call 2010 European Research Projects on Mental Disorders. G07 (M. Desco). European projects submitted in 2010 and not approved Neurobiological and environmental shared risk factors in mental disorders related to compulsivity and impulsivity. Convocatoria NEURON-ERANET. G17 (JM Menchón). Understanding neurodevelopmental mechanisms of schizophrenia:a translational strategy integrating clinical and basic findings. Convocatoria NEURON-ERANET. G26 (B Crespo-Facorro). BICORE BIpolar COgnitive REmediation. Convocatoria NEURON-ERANET. G25 (E Vieta). 30

31 CORE-BIP COrrelates of REsponse in BIPolar. Convocatoria EraNet-Neuron. G25 (Colom F) European Twin study on the genetic effects and epigenetics determinants of white matter conectivity in bipolar affective disorder and at-risk subject. Convocatoria NEURON-ERANET. G08 (L Fañanás). Inflammation and Human Endogenous RetroVirus W InSchizophrenia: a translational study. Convocatoria NEURON-ERANET. G26 (B Crespo-Facorro). Biomarkers for first-episode psychosis (the FEPBIO consortium). Convocatoria. EraNet- Neuron. G01 (Arango C) Dopaminergic dysfunction in the prefrontal cortex (PFC). Convocatoria EraNet-Neuron. G01(Arango C) Neurobiology of Bipolar Prodrome. Convocatoria NEURON-ERANET. G22 (J Saiz). European Research Cartel in Suicidal behaviour (EURECA-suicide): improving the prediction of suicidal behaviour by using the neuroscientific toolbox (genomics, neuropsychology). Convocatoria NEURON-ERANET. G22 (E. Baca-García), G05 (J. Bobes). An Integrated Model for the Early Detection of Major Phychoses BrainKit. Convocatoria. Large-scale Integrated Project (IP), Objective ICT : Virtual Physiological Human Topic A: VPH Call 6. G26 (Crespo-Facorro B) Determinants of alcohol consumption and impact on functioning, health and disability. Comparisons between European countries. Convocatoria European Research Advisory Board - Research Grants : EA G03 (R. Nuevo). European projects submitted in 2010 and approval pending during 2011: ROAMER Roadmap for Mental Health Research in Europe. FP7-HEALTH-2011-singlestage: G11 (JM. Haro), G03 (JL. Ayuso), G01 (C.Arango), G10 (A. González-Pinto), G25 (E. Vieta), G26 (B. Crespo-Facorro), G06 (J. Cervilla). 31

32 2010 ANNUAL REPORT Institutional Relations The purpose of the CIBERSAM Institutional Relations Area is to foster a fluid communication with the professional environment and to coordinate the relationship with institutions such as the Instituto de Salud Carlos III, Centro Superior de Investigaciones Científicas, other public researching institutions and ministries. The aim is to promote the coordination with the consortium members and improve the CIBERSAM visibility in society. Miquel Bernardo Arroyo Coordinator of the Institutional Relations Area Within this area, the following activities were carried out in 2010: Madrid Statement against Stigma of mental diseases Contact with different organizations: FEAFES (Madrid, Andalucía), Ressorgir, ATBAR, Hierbabuena, La Nostra Veu, Mundo Bipolar, ACFAMES Organization of the 9th Congress on Multiple Modality of Psychiatric Disorders Organization of the 2nd Social Forum within the 14th National Congress on Psychiatry, Barcelona Nise project: against the stigma of mental diseases. Collaboration with the Servizo Galego de Sáude. Meetings with representatives of the Health Ministry to obtain support for the development of the project Road Map for Mental Health Research (ROAMER). Relationship with media: different television channels and press. 32

33 Quality and Internal Evaluation During 2010, actions such as the standardization of administrative procedures and the completion of the necessary steps for ISO 9000 quality accreditation were undertaken. Through an audit, it was verified that CIBER of Mental Health fulfils the requirements set forth in ISO 9001:2008. Ana González-Pinto Coordinator of the Quality and Internal Evaluation Area In this context of improvement, evaluations are necessary and in CIBERSAM, the focus is on the evaluation of the structure, the processes and the scientific production: Structure: focusing on the qualification, technological capacity, facilities, economic and administrative organization, and management of human and material resources. Processes: emphasizing the attainment of the mission of CIBER, the relevance of its activity at the national and international level and the coherence of the planning, dissemination and publication of the results. Scientific Production: in this area, the production in relation to available resources, the number of publications, projects, patents and changes over time are valued. CIBERSAM has a code of Good Research Practices which is adopted by all of its researchers. The observance of a code of good scientific practice involves upholding ethical principles and legal requirements in accordance with the international ethical research standards set forth in the Declaration of Helsinki (the obtaining of informed consent, a detailed evaluation of the risk/benefit analysis of the study and the impartiality in the selection and the follow-up of the participants in the study) as followed by the Committee of Good Scientific Conduct (CBCC) of CIBERSAM; these are essential elements in any research project that aims to expand scientific knowledge within a framework of credibility and respect from society. CIBERSAM has also incorporated in its Quality Management System an operating protocol based on national and international ethical standards for the handling and transportation of biological samples between CIBERSAM laboratories (those of experimental animals as well as cell experiments derived from patients or controls) such that it ensures at all times the quality and stability of the samples, including the related data, under its control. 33

34 2010 ANNUAL REPORT CIBER of Mental Health has a system for quality supervision of its research and management activities. In 2010, based on the results of an internal audit of CIBERSAM, corrective actions, for improvements as well as preventions, were undertaken in the areas of management and research activities. The Steering Committee, the Scientific Council, the coordinators and heads of areas, lines and/or projects supervise the achievement of the objectives and oversee that the scientific methods have adequate quality attributes. Works of improvement have been undertaken with respect to the following issues: 1. Scientific and training policies. 2. Specific policies. 3. Nation-wide identification of public and private, national or regional institutional bodies (OPIS) and checking for duplication from other institutional bodies. 4. Recording of the performance process of scientific advancement and knowledge. 5. DAFO: criteria. 6. Documents that specify specific measures and results. 7. Weaknesses. 8. Programme for cooperation and alliances (as set forth in the Multi-year Plan). 9. Process for prioritizing strategies. 10. Verifiable description of activities to correct strategic deficiencies which are detected. 11. Scientific planning documents with multi-year objectives and indicators for follow-up. 12. Scorecard. 13. Management contracts with defined responsibilities (results and time periods). 14. Performance evaluation results of the executive management. 15. Definition of the quality. 16. Records of the quality of the laboratories. 17. Procedures / methods to ensure the traceability of biological samples. 18. Improvement and preventive actions in management areas and research activity/ corrective actions / prior audits. 19. Staff handbook. 20. Plans for creativity / teamwork / empowerment. 21. Incentive systems / awards. 22. Actions to optimize the internal working environment. 23. Process maps: although improvement is possible, these maps are not modified by prioritizing more efficient changes, rather a map of procedures is added to them. 24. Records that demonstrate actions that improve processes and results. 34

35 Results and Communication The aim of the CIBERSAM Results and Communication Area is to disseminate the findings and the research activity among the scientific community, society, the economic world and the clinical practice. This dissemination results in a better exploitation of the CIBER capacities and findings. Julio Bobes García y Juan Antonio Micó Segura Coordinators of the Results and Communication Area In 2010, the following CIBERSAM research activities were spread: Organization of scientific events. Participation in events of the Psychiatry Spanish Society (PSS) and of the Biological Psychiatry Spanish Society (BPSS): 2 nd Social Forum on Mental Health within the 14th National Congress on Psychiatry, which was organized by the PSS and the BPSS and took place on the 18th October 2010 in Barcelona. 35

36 2010 ANNUAL REPORT CIBERSAM Common Data Base The main purpose of the CIBER centres (Centre for Biomedical Network Research) is to foster joint research. In order to deal electronically with the whole set of data, it is necessary to establish procedures, criteria, scales and individual fields of work so that the different information resources can be integrated and later on this information can be processed. Julio Sanjuán Arias Coordinator of the Common Data Bases Area In this context, CIBERSAM cooperates with the research group Grid y Computación de Altas Prestaciones (Grid and High Performance Computing, GRyCAP from the Universidad Politécnica de Valencia (UPV and collaborates with the United Kingdom network on mental health research PsyGrid ( The group GRyCAP is developing a data capture and pre-processing system called GridSAM ( gridsam.grycap.upv.es), which is currently being used for some of the projects. This system allows to the participating groups to enter and share clinical and genomic data. During the year 2010, the GridSAM system features have been extended as follows: In cooperation with the Santiago de Compostela platform, a system has been created to capture genetic data and to combine them with clinical data; In cooperation with the neuroimaging platform, an integration system for morphometry data was created within the first episodes project; The sample gathering has been going on and has been extended in the collaboration projects already existing in 2009 within GridSAM: First Episodes Project, GWAS Project. Moreover, the use of the common data base platform has been extended to new projects: Depregen Project Child Pathology Project Finally, a general data base has been added so as to include any kind of patient whose DNA was obtained via the PGen base. 36

37 Platforms During 2010, the clinical data platform was also created, coordinated by Dr. Julio Sanjuán. These facilities are equipped and staffed by highly qualified personnel, providing an important support for research. The platforms give support to research groups that are part of CIBERSAM as well as outside groups that conduct research activities in Mental Health. The DNA Platform has more than 5,000 samples from people with mental disorder and also includes samples of other pathologies and healthy control samples. The Brain Bank Platform provides samples of brain tissues of people with mental disorder and control specimens to research groups who require them. The Bank of Instruments Platform provides information and service to researchers regarding questionnaires and measurement tools on mental health. The Therapeutic Target Platform gathers facilities and professionals who give support to researchers that want to analyze new targets for treatment, with the end goal of acting as an available distributed platform of choice when necessary. The Neuroimaging Platform is a technical group whose principal objective is to promote the use of quantitative analytical techniques in Neuroimaging. The Clinical Data Platform provides an online registry tool of socio-demographic, clinical and research information that supports multidisciplinary studies and permits the use of data by the CIBER groups. Josep Mª Haro Coordinator of the Platforms Area CIBERSAM has 5 platforms that support research: DNA Platform Library of Instruments on Mental Health and Disability Brain Bank Identification and Verification of Therapeutic Targets Neuroimaging 37

38 2010 ANNUAL REPORT DNA Bank Platform Dr. Celso Arango López (G01) Coordinator of DNA Bank Platform Members of the Scientific Committee: Dr. Julio Sanjuán Arias (G23) Dra. Lourdes Fañanás Saura (G08) Dr. Jorge Cervilla Ballesteros (G06) Dr. Josep Maria Haro Abad (G11) During 2009 and 2010, 5,741 samples from schizophrenia patients from 10 hospitals were deposited. CENTER City DNA samples Universidad Granada Granada 1,742 Universidad de Valencia Valencia 1,015 Hospital 12 de Octubre Madrid 948 Hospital Gregorio Marañon Madrid 626 Universidad de Oviedo Oviedo 459 Hospital Santiago Apóstol Vitoria 295 Hospital Sant Pau i Santa Creu Barcelona 290 Hospital Sant Joan de Déu Barcelona 176 Hospital Ramón y Cajal Madrid 100 Hospital Clínic Barcelona 90 TOTAL 5,741 38

39 Library of Instruments on Mental Health and Disability Platform Dr. Josep Maria Haro Abad (G11) Coordinator of Library of Instruments Platform Members of the Coordinating Committee: Dr. Josep M. Haro (G11) Dra. Ana González-Pinto (G10) Dr. Eduard Vieta Pascual (G25) Dr. José Luis Ayuso (G03) Dr. Julio Bobes (G05) Dr. Antonio Lobo (G13) Dr. Celso Arango (G01) The Library of Instruments on Mental Health and Disability has more than 100 instruments which are organized per the different areas of interest. The bank has 160 instruments: 9% of which correspond to the area of diagnostic, 24% in the area of symptomatology, 11% in children/adolescence, 8% in special populations, 0% in dual pathologies, 13% in neuropsychology, 8% in disability and 27% in miscellaneous. In 2010, a call for intramural projects was made again for the development of instruments. 31 projects were submitted and 9 were accepted. During the years 2008, 2009 and 2010, three classroom training days, in the form of a workshop, were dedicated to revising the design and research implementation process with respect to case study for purposes of developing and validating questionnaires on Mental Health and Disability. The library of CIBERSAM has a collaborative relationship with BiblioPRO (Library of Patient Related Outcomes), which is managed by the Research Unit of Health Services of IMIM Hospital del Mar, member of CIBERESP (Center for Biomedical Research in the Public Health Network). 39

40 2010 ANNUAL REPORT Brain Bank Platform Dr. Jose Javier Meana Martínez (G16) Coordinator of the Brain Bank Platform The Bank Platform and the brain samples collection represent a basic structure in translational psychiatric research. Currently, there are three nodes linked to the groups of the Fundació Sant Joan de Déu, the Universidad del País Vasco and Universidad de Cantabria. The Platform assembles samples using the criteria of quality, clinical data of the donor and toxicological data. During 2010 a new toxicological service that provides specific analysis for the member groups was established. 85 new samples have been added to the bank and 136 were transferred. Throughout 2010, the techniques for determining the quality of the samples by incorporating indicators such as RIN (RNA integrity number) have improved. The area of toxicology now allows for the possibility of measuring psychoactive drugs in the brain tissue through the use of sophisticated analytical techniques. Furthermore, the year 2010 oversaw the opening of new centres of donor recruitment. The Fundació Sant Joan de Déu joined the Biobancos Network which is sponsored by the Instituto de Salud Carlos III. Throughout 2010, the process of recruiting donors, obtaining samples and transferring samples to national and international scientific projects has continued. At the intramural level, seven groups of CIBERSAM have received sample donations in order to carry out projects and lines of work. 40

41 Platform of Identification and Validation of Therapeutic Targets Dr. Ángel Pazos (G20) Coordinator of the Platform of Identification and Validation of Therapeutic Targets Members of the Coordinating Committee: Dr. Ángel Pazos (G20) Dr. Francesc Artigas (G02) Dr. Josep M. Haro (G11) The Platform of Therapeutic Target gathers a series of infrastructures and a methodology set forth by several CIBERSAM groups, mainly of basic nature, so that it can act as a decentralized platform of available offers for the collaborative studies planned within CIBERSAM, especially in relation to the identification and validation of therapeutic targets and of etiopathogenesis. Services This platform is available to any CIBER researcher working on a project requiring this kind of methodological approaches. The following services can be found within those approaches: Studies on localization and expression of receptors and analysis of their mechanisms of cellular signaling. Studies on regulation and modulation of neural signaling proteins in animal models and through psychoactive drugs. Studies on the behaviour of animal models of psychiatric pathology both genetic and functional. Studies on micro-dialysis: characterization of animal models and effects of psychoactive drugs. Studies on electrophysiology: characterization (in vivo as well as in vitro) of animal models and effects of psychoactive drugs. Studies on the activity assessment (affinity, effectiveness) of active molecules in the nervous system. Development of animal models based on gene expression and alterations of the neurodevelopment. 41

42 2010 ANNUAL REPORT Equipment In 2010 the acquisition process of all the specific equipment for the platform has finished. It began in 2009 and the whole equipment consists of: Equipment of extra-cellular multi-record, with the aim of recording the neuronal activity in awake rodents (Group 02 in charge of it). Chromatograph of liquid phase type FPLC/HPLC (Group 09 in charge of it). Multimodal scanner for micro-plates and trays (Group 12 in charge of it). Flux cytometer (Group 16 in charge of it). Patch-Clamp equipment (Grupo18 in charge of it). Stereoataxic board for rodents, with dissection table and vibratome (Group 20 in charge of it). Real time PCR equipment (Group 24 in charge of it). Use of the equipment Although most part of the equipment took several months to be operative, in several cases the platform has been already used to carry out research projects in which several CIBERSAM groups took part as well as to do experiments resulting in publications. Intramural projects in which the equipment was used: 5 Neuroimaging Platform projects: 1 Competitive national projects: 5 International articles: 6 42

43 Neuroimaging Platform Dr. Manuel Desco (G07) Coordinator of the Neuroimaging Platform Members of the Coordinating Committee: Dr. N. Bargalló (G04) Dr. Santiago Reig (G07) Dr. Josep Maria Haro (G11) Dr. Salvador Sarró (G15) Dr. Julio Sanjuán (G23) Dr. Benedicto Crespo (G26) The Neuroimaging Platform is a technical group within CIBERSAM whose principal objective is to promote the use of quantitative analysis techniques in Neuroimaging. The Platform serves as a vehicle for contact among the groups specializing in processing and analysis within CIBER of Mental Health. It also provides the connection between clinical users and outside groups with reliable technical experience in image processing. The physical assets are located in the Medical Image Laboratory, Experimental Medicine and Surgery Unit of Hospital General Universitario Gregorio Marañón of Madrid under the supervision of Manuel Desco (G07). The members of the coordinating committee aren. Bargalló (G04), S. Reig (G07), J. Haro (G11), R. Salvador (G15), J. Sanjuán (G23) y B. Crespo-Facorro. The services of the Platform are available to all researchers of CIBERSAM. Among the activities engaged by the Platform in 2010, the maintenance and the upgrade of the DICOM image server via the web deserves special mention. The volume of images in 2010 exceeded 400 studies that include distinct types of RM. With respect to the resources available within the Platform, two Linux servers for processing have been added. In addition, the upgrade and expansion of the available processing tools have continued. 43

44 2010 ANNUAL REPORT 2010 Activities: Technical projects developed during 2010 by the Platform:: - A connectivity atlas of the human brain. IP: E. Canales (G15), G07 (Centro Neurociencias Cuba) - Diffeomorphic registration tool for morphometric analysis by tensor based morphometry. IP: M. Desco (G07), G01, I3A - Integration of DTI fiber-tracking parameters as constraints in models to evaluate effective functional connectivity. IP: G. García-Martí (G23), G07 - Evaluation of automatic methods for cortical parcelation, automatic (FreeSurfer y IBASPM) and manual (BRAINS2). IP: B. Crespo Facorro (G26), G01, G07 Participation of the Platform in intramural and extramural joint projects in Neuroimaging Research support: - Training placements (G15, G04, G10) - Acquisition service for animal imaging (G18, G01) Annual meeting of the Platform in Valencia on December 15, 2010: - Presentation of completed projects from the 2009 round - Objectives and future plans for the Platform Call for proposal, evaluation and decision of Intramural projects of the Platform for Collaborations with outside groups: Philips, Instituto de Investigación en Ingeniería de Aragón (I3A), Institut d Investigacions Biomèdiques August Pi y Sunyer (IDIBAPS), Centro Nacional de Investigaciones Oncológicas (CNIO), Centre d Imatge Molecular (CRC CIM), Novasoft y Sociedad Española de Electromedicina y Calidad (SEDECAL). Number of images in the platform for transmission of images 150 Number of studies and processed images 70 Number of available tools 10 Number of Platform projects for methodology development 5 Conducting Scientific workshop 1 44

45 FIGURES and NEWS CIBERSAM in figures...46 CIBERSAM in the News

46 2010 ANNUAL REPORT CIBERSAM in figures In this section we aim to portray, in a general, graphic, and intelligible way, the activities carried out by CIBERSAM in its third year of existence. The data are presented according to the resources, processes, and achieved results. An analysis has been made of the obtained funds as well as of the projects and publications done in Research projects Launching collaborative projects is one of the outstanding actions of CIBERSAM. Our organization forsters collaboration between its research groups. This collaborative activity includes not only projects, but also joint publications, training activities, and even the CIBER management. Number of collaborative projects 46

47 Number of projects per group Most groups (except for five) have more than 40% of collaborative projects and in 18 out of the 26 groups more than 50% of their projects are collaborative. Percentage of collaborative projects 47

48 2010 ANNUAL REPORT Ratio Collaborations / Projects Publications Quartile Quartile Nº Total 290 Quartile 1 Quartile 2 48

49 Journals Decile There were published: 8 magazines with 3 publications 16 magazines with 2 publications 46 magazines with 1 publication One of the main objectives of CIBERSAM is excellent productivity. This graphic shows that 38% of publications appeared in first decile magazines and more than 50% of the total amount of articles was published in magazines between the first and second deciles. Decile 1 Decile 2 Decile 3 Decile 4 Decile 5 Decile Nº % Decile ,9 Decile ,2 Decile ,5 Decile ,5 Decile ,9 Total

50 2010 ANNUAL REPORT Number of Publications Number of publications per group First and second quartiles Quartile 1 Quartile 2 50

51 Joint Publications This graphic stands for joint publications of the 26 CIBERSAM groups. The circle s size is equivalent to the total amount of publications of a group (first and second quartiles). We show joint publications in which a group has 2 publications at least with another CIBERSAM group. 51

52 2010 ANNUAL REPORT Ratio between amount of articles and amount of joint articles Cumulative impact factor per group 52

53 53

54 2010 ANNUAL REPORT CIBERSAM in the News Research should have an impact on society in order to create a scientific culture and a social awareness of mental illnesses and their problems. In 2010, CIBERSAM organized and participated in many activities. This report aims to capture the most noteworthy of the news featuring the Centre, such as events in which the consortium participated or acted as organizer. This dissemination and communication has been possible due to the work carried out by the professionals of CIBERSAM, who bring awareness, to society in general as well as to the scientific community, of the activity undertaken by the biomedical research Centre network. Eduard Vieta will join the Advisory Committee of the Hungarian European Presidency in 2011 (25/02/2010) Dr. Vieta, principal researcher of the G25, has been invited to participate in the Advisory Committee to be established by the Hungarian European Presidency in the first half of In the Research, Development and Innovation area, Hungary has decided to prioritize brain research and, with respect to the field of Neuroscience, to focus on neuropsychiatric illnesses, with special attention to depression, anxiety and schizophrenia. Eduard Vieta has accepted the invitation of the Hungarian Academy of Sciences. CIBERSAM referenced in the Mental Health Strategic Plan of the Region of Madrid (18/03/2010) The Strategic Mental Health Plan of the Region of Madrid devoted a specific section to the Centre of Biomedical Research Mental Health Network. On page 211, it is underlined that of the 26 groups that are part of CIBERSAM, 8 are from the Region of Madrid, which makes this region, along with Catalonia, the one with the most number of groups belonging to CIBER of Mental Health. It also states that the fact that the Region of Madrid, of the 9 existing CIBERs, has the largest number of groups visà-vis other regions and is the only one with a Scientific Director from Madrid highlights the competitiveness of the mental health research groups based in Madrid. Prepared by the Madrid Health Service in collaboration with professional groups and patients, the Madrid Mental Health Strategic Plan establishes the principal lines of work in the Mental Health area to be developed by the Region in the next few years. 54

55 AstraZeneca launches PuedoSer.es, an innovative project that connects social networks with bipolar disorder (03/06/2010) The company AstraZeneca introduced an innovative project concerning social networks and bipolar disorder that can be found on the social network The platform is an online community in which any individual can participate by interacting with other users (whether patients or psychiatrists) or simply by using it as a source of reliable information regarding bipolar disorder from a scientific viewpoint as well as a more personal perspective, with the aim of removing taboos and stigma associated with mental illnesses. CIBERSAM collaborated on this project. Dr. Eduardo Vieta, Director of the Bipolar Disorder Program of the Hospital Clinic of Barcelona and Principal Researcher of CIBERSAM, Dr. Celso Arango, Scientific Director of CIBERSAM, Ignacio Parada, expert on health social networks and founder of Vi.Vu and Federico Plaza, Director of Corporate Relationships of AstraZeneca participated in the presentation ceremony. CIBERSAM gives out Young Scientist Awards to researchers in the early stages of mental illnesses (22/11/2010) As part of the 8th International Meeting on the early stages of mental illnesses (Genes and Environment: from Etiopathogenesis to the Treatment of Psychosis), held in Santander from the 18th to the 20th of November 2010, CIBERSAM granted Young Scientist Awards in this research area. The five awards were sponsored by Nova Caixa Galicia. The Evaluating Committee consisted of Professor Lourdes Fañanás Saura, Professor Jesús Artal, Professor Benedicto Crespo Facorro and the Scientific Director of CIBERSAM, Celso Arango. Several researchers of CIBERSAM were given awards in 4 of the 5 categories: First Prize for the Best Oral Presentation, Third Prize for the Best Oral Presentation, First Prize for the Best Poster Presentation and Runner-up for the Best Poster Presentation. More news can be found at (News) 55

56 2010 ANNUAL REPORT Press The Scientific Director of CIBERSAM is the author of an article published in The Parliament Magazine An article by the Scientifc Director of CIBERSAM was published in the issue 302 of the European Parliament s magazine (22 nd February, 2010, p. 131). Entitled A coordinated approach, in this article Celso Arango talks about the need to increase research funds in psychiatry and notes that schizophrenia is one of the most devastating diseases in Europe due to the human suffering it provokes and its associated social costs. Selection of 2010 Press Releases Discovery of an area in the brain where schizophrenia can be localized (25/01/2010) The international scientific community may be closer to knowing the causes of schizophrenia after the study carried out by the Psychosis and Research Unit of Benito Menni CASM, part of the CIBERSAM network, which revealed structural and functional changes in the medial frontal cortex. This research, which was published in the prestigious journal Molecular Psychiatry is especially important because no other previous work concerning this illness had found structural and functional cerebral anomalies in this part of the brain. The team lead by Dr. Edith Pomarol-Clotet conducted this study by examining and comparing the brains of 32 patients with schizophrenia against those of 32 healthy individuals through the use of three different resonance techniques. 56

57 Researchers of CIBERSAM discover the gene protein ANKK1 (03/02/2010) A Spanish research group published an article in Biological Psychiatry which shows for the first time the pattern of expression of the gene ANKK1. This new protein is found in the adult central nervous system (CNS), in humans and rats, exclusively in the astrocytes and in mice undergoing embryonic development of CNS in the radial glía. In vitro studies of astrocytes in mice treated with apomorphine suggest a possible relationship between ANKK1 and the dopaminergic system. This study was conducted at the Neuroscience Laboratory of the Psychiatry Service located at the Research Unit of Hospital 12 de Octubre and included the participation of 9 researchers of this Centre. Seven of them -Janet Hoenicka, Adolfo Quiñones-Lombraña, Laura España-Serrano, Roberto Rodríguez-Jiménez, Miguel Ángel Jiménez-Arriero, Guillermo Ponce and Tomás Palomo- belong to G19, which is led by Dr. Palomo, Coordinator of the Schizophrenia Area. CIBERSAM leader of publications on psychiatry in Spain (4/11/2010) CIBERSAM is credited with having 494 publications since its inception of only 3 years, which makes this research consortium on mental health the entity with the most publications on psychiatry in Spain in the last 10 years. The data were obtained from the bibliometric psychiatry study carried out by CIBERSAM with its ISI Web of Knowledge as the source. This study concluded that the principal journals with the most CIBERSAM publications are the Journal of Affective Disorders with 27 contributions and Schizophrenia Research with 21. The number of CIBERSAM references in the period was The research group of CIBER of Mental Health, led by Dr. Eduard Vieta of Hospital Clinic of Barcelona, had the most articles published in 2009 with 65 publications. Dr. Vieta was the most prolific Spanish psychiatrist having a total of 418 publications during the same period. For further information see (Press) 57

58 2010 ANNUAL REPORT Events THE 2nd SOCIAL FORUM ON MENTAL HEALTH NO MENTAL HEALTH WITHOUT RESEARCH The 2nd Social Forum on Mental Health No mental health without research was held on October 8, 2010 during the 14th National Psychiatry Conference in Barcelona. This event, which was organized by CIBERSAM, succeeded in bringing psychiatrists and patients closer together. With a large presence of people affected by mental illnesses and with the attendance by Catalan associations such as Ressorgir, AFEMHOS o FECAFAMM, this meeting achieved its goal: the creation of a close and direct dialogue between medical specialists and their patients. The Scientific Director of CIBERSAM, Celso Arango, stressed the importance of the Social Forum as a place to meet and exchange ideas between doctors and patients, clearly noting that clinical research and care are inseparable and must take the patient into account. At the round table dedicated to scientific research on mental health, four principal researchers of CIBERSAM explained the results of their studies and the open lines of research in their respective disciplines. THE 14th NATIONAL PSYCHIATRY CONFERENCE CIBERSAM participated in the 14th National Psychiatry Conference, organized by the Spanish Society of Psychiatry (SEP), the Spanish Society of Biological Psychiatry (SEPB) and the Spanish Foundation of Psychiatry and Mental Health, that was held in Barcelona from the 18th to the 22nd October More than 20 researchers from CIBERSAM received awards in the following categories: Award for Excellent Research Program (Principal Researcher from G10), the Award for the Best Program in Training Innovation for Residents (G19), Researcher of the Year Award (Principal Researcher of G02), 15th Amadeo Sánchez Blanqué Award for the Best Poster in Clinical Research in Psychiatry (G01), 8th Neuroscience Award for the Best Posters (G14 and G10). 58

59 10th SCIENCE WEEK OF THE REGION OF MADRID TRANSLATIONAL RESEARCH The 9 Biomedical Research Network Centres (CIBER), supported by the Instituto de Salud Carlos III (Science and Innovation Ministry) explained the keys to network translational research during the round table held on November 16, CIBERSAM was represented by the presentation entitled Neuroimaging: from physics to the visualization of psychiatric disorders and their treatment by Dr. Roberto Rodríguez-Jiménez, coordinator and member of the research group at Hospital Universitario 12 de Octubre of Madrid. 11th MULTIMODALITY CONFERENCE ON PSYCHIATRIC DISORDERS: RELATIONSHIPS, CONNECTIONS AND ALTERATIONS 3RD LIBRARY WORKSHOP ON INSTRUMENTS ON MENTAL HEALTH AND DISABILITY CIBERSAM LABORATORY OF IDEAS FOR YOUNG RESEARCHERS 11TH SYMPOSIUM ON BIPOLAR DISORDERS 5TH ALICIA KOPLOWITZ FOUNDATION SCIENCE WORKSHOP 59

60 2010 ANNUAL REPORT INTERNATIONAL CONFERENCE ON NEUROIMAGING IN BARCELONA 1ST INTENSIVE INTRODUCTORY COURSE ON PSYCHOPATHOLOGY AND DIAGNOSIS OF MENTAL ILLNESS FOR BASIC RESEARCHERS IN NEUROSCIENCE WORKSHOP ON TREATMENT PROGRAMS FOR FIRST PSYCHOTIC EPISODES supported by CIBERSAM CIBERSAM participation in the THIRD EUROPEAN BRAIN POLICY FORUM CIBERSAM presentation in the FEAFES ANNUAL WORKSHOPS For further information see (Agenda) 60

61 Research Areas Depression...62 Schizophrenia Bipolar Disorder...66 Other Mental Disorders... 68

62 2010 ANNUAL REPORT Depression Area Main milestones in 2010 Use of interference RNA techniques (sirna) for a selective genes annulment in the central nervous system so as to achieve antidepressant effects. Antidepressants action mechanism through the study of different receptors. Gene-environment interaction in Depression. Study on genetic predisposition factors and on response to drugs. Creation of a tool foreseeing depression risk. Application of DBS in animal models with depressive disease (micro-dialysis and AD response) Validation of several assessment and change tools in depressive patients. Implantation of a Proteomics Service so as to identify diagnostic markers and therapeutic targets for drugs designing. Results of MR spectroscopy concerning different phases of DM. Future research lines Studies on first depressive episodes: MR exam, telomere length, and telomerase activity. Cellular and molecular bases of depression and of the action mechanism of antidepressant drugs. Intracellular signaling targets. Study on the role of potasium-k+ and TREK-1 channels in the action mechanism of antidepressant drugs. Role of prefrontal cortex in the physiopathology and treatment of depression in animal models. Modulation of genes associated to the serotonergic system with antisense RNA molecules (sirna) and its effect on depression models. Collaboration projects between basic and clinical researchers: from the animal model to the patient, from genetics to clinic, as well as neurochemistry and molecular biology. PET and MR study in DBS: structural localization in MR and identification of metabolic changes in DBS. Study on the Deep Brain Stimulation technique in the treatment of refractory depression in Bipolar Disorder. 62

63 Contributing groups to this Area in 2010 Area coordinator: Víctor Pérez Solá GROUP Principal Investigator CENTER G02 Francesc Artigas Pérez Instituto de Investigaciones Biomédicas, Barcelona G06 Jorge Cervilla Ballesteros Universidad de Granada, Granada G08 Lourdes Fañanás Saura Universidad de Barcelona, Barcelona G09 Javier Garzón Niño Instituto Cajal - CSIC, Madrid G16 Javier Meana Martínez Universidad del País Vasco, Leioa-Vizcaya G20 Ángel Pazos Carro Universidad de Cantabria, Santander G21 Víctor Pérez Solá Hospital de la Santa Creu i Santa Pau, Barcelona 63

64 2010 ANNUAL REPORT Schizophrenia Main milestones in has been a particularly prolific year for the CIBERSAM s schizophrenia area. In this programme, 103 articles have been published, of which 93 (90.3%) in the first and second quarters and 44 (42.7%) in the first ten months. This represents a cumulative factor of for this programme in From a qualitative point of view, the most relevant 2010 publications in this programme were focused on the following lines of research: First Psychotic Episodes. This multiple-centre project, in which 17 groups participate, has followed its course and, on the whole, has attained its objectives. It will be finished in There have been significant publications on clinical aspects and neuroimaging as evolution foreseers. Neuroimaging in Schizophrenia. There have been papers on the neuroimaging new technologies, with a special emphasis on the works focused on the connectivity problems in schizophrenia. Genetic Risk Factors. New risk polymorphisms have been identified and, in some studies, they have been correlated to neuroimaging endophenotypes. Physical health and schizophrenia. Biological markers have been identified to define aspects of the physical health of schizophrenic patients. Future research lines Extension of the common DNA bank of psychotic patients in order to reach the figures of 7,000 patients and 5,000 controls with a view to participate in collaborative projects with international consortia for psychosis GWAS studies. First episodes follow-up. Identification of genetic and environmental risk factors and their interaction in the emergence of a first psychotic episode. We are going to ask for a coordinated project so as to keep on following up already identified first-episode patients. Research on the efficiency and the effectiveness in schizophrenia of the psychopharmacologic and psychotherapeutic treatments as well as the psychosocial interventions. Study on the consequences of schizophrenia on health condition, psychosocial fitting, life quality, the disability levels of the individual and the services patterns of use developed by these patients and their influence on comorbidity. 64

65 Contributing groups to this Area in 2010 Area coordinator: Julio Sanjuán Arias GROUP MAIN RESEARCHER CENTER G01 Celso Arango Hospital Gregorio Marañón, Madrid G04 Miquel Bernardo Hospital Clínico, Barcelona G05 Julio Bobes Universidad de Oviedo, Oviedo G08 Lourdes Fañanás Universidad de Barcelona, Barcelona G10 Ana M. González Pinto Hospital Santiago Apóstol, Vitoria G11 Josep María Haro Hospital San Joan de Déu, Barcelona G15 Peter J. McKenna Hospital Benito Menni, Barcelona G16 Javier Meana Universidad del País Vasco, Leioa-Vizcaya G19 Tomás Palomo Hospital 12 de Octubre, Madrid G22 Jerónimo Saiz Hospital Ramón y Cajal, Madrid G23 Julio Sanjuán Arias Universidad de Valencia, Valencia G26 Jose L. Vázquez Hospital Marqués de Valdecilla, Santander 65

66 2010 ANNUAL REPORT Bipolar disorder Area Main milestones in 2010 In 2010 were particularly outstanding the epidemiologic collaborative projects between CIBERSAM groups and with international groups, the development of clinical practice guides to be applied to the health system, studies on first-episode and neurocognitive dysfunction patients and their associated disability, the development and validation of psychometric instruments, innovative clinical trials and new techniques of psychosocial intervention. Findings were published in the most prestigious publications, such as New England Journal of Medicine, Bipolar Disorders, and Journal of Clinical Psychiatry. Progresses have been made to register a new patent and new knowledge generated by CIBERSAM has been made available to other practitioners and to the population in general via the innovative social network in collaboration with the private sector. CIBERSAM has been able to generate an important amount of resources and projects which, in the near future, will turn into new contributions to the understanding and the evolution of Bipolar Disorder treatment. Extremely interesting studies are being carried out that combine neuroimaging, neurocognition, and clinical and neurobiological correlates. Progresses are made in neurogenesis and neuroplasticity mediators as means to evaluate resilience and to predict the disease evolution and its physical and psychiatric comorbidity. Interventions have been developed to act early and to facilitate an effective neurocognitive and functional rehabilitation. Funds have been granted to carry out clinical trials promoted by CIBERSAM with innovative designs. CIBERSAM groups take part in a European network sponsored by the 7th Framework Programme (ENBREC). In short, CIBERSAM has undoubtedly become the Spanish institution, and probably the European one, that nowadays researches the most on Bipolar Disorder. Future research lines Telemedicine applied to bipolar disorder Bipolar type schizoaffective disorder Bipolar disorder and cancer 66

67 Contributing groups to this Area in 2010 Area coordinator: Eduard Vieta Pascual GROUP Principal Investigator CENTER G03 José Luis Ayuso Hospital de La Princesa, Madrid G05 Julio Bobes Universidad de Oviedo G10 Ana González-Pinto Hospital Santiago Apóstol, Vitoria G18 Juan Antonio Micó Universidad de Cádiz G24 Rafael Tabarés Universidad de Valencia Instituto de Neurociencias de Alicante G25 Eduard Vieta Hospital Clinic de Barcelona 67

68 2010 ANNUAL REPORT Other Mental Disorders Main milestones in 2010 Among the 2010 achievements in this CIBERSAM area the following ones can be underlined: Research on the inflammatory mechanisms independently from the Aß levels. Study on the regulatory role of the cannabinoid receptor 1(CB1) in stress induced excitotoxicity and neuroinflammation. Effect of depression characteristics on the appearance of incidental diabetes. No connection has been found between moderate alcohol consumption and risk of cognitive deterioration. Compulsive hoarding: OCD symptoms, a syndrome or both? Study on altered corticostriatal functional connectivity in OCD. OCD protective haplotypes (extensive genotyping of BDNF and NTRKC genes) Suicidal conduct, separate diagnostic or separate axes? Works on suicidal ideation and suicide attempts. International WHO on the relationship between gender and mental disorders. Effect of the attenuated psychotic syndrome on adolescent psychiatry. Anxiety and logos as basis for the linguistic study of the origin of human thinking. New projects have been achieved on stress induced neuroinflammation of the central nervous system; evaluation of the reward processing, deep brain stimulation; study on the connection between the gene variables COMT, 5-HTLPR and BDNF and the brain response patterns in complex emotional paradigms in OCD. Moreover, we have began collaborating with the Scientific Committee of EDCON International Group to develop a scale to measure dementia stages. This project is funded by the MADARIAGA-College of Europe Foundation. Future research lines Development of a research line on inflammation related to anxiety disorders and other disorders of this area. Leadership of a research on psychiatric pathology services in hospitals and first medical care facilities. Development of longitudinal epidemiologic studies and of risk factors studies in medical population, including first medical cares, and sharing epidemiologic data bases. Development a line of work on suicide. Development of studies on obsessive compulsive disorder. Leadership of the research on disorders with psychic and somatic comorbidity. Leadership of the research on genetics and neurobiology of impulse control disorders. Leadership of the research on child and adolescent psychiatry. 68

69 Contributing groups to this Area in 2010 Area coordinator: Antonio Lobo Satué GROUP Principal Investigator Center G01 Celso Arango Hospital General Universitario Gregorio Marañón, Madrid G12 Juan Carlos Leza Universidad Complutense, Madrid G13 Antonio Lobo Hospital Clínico Universitario-Instituto Aragonés de Ciencias de la Salud, Zaragoza G14 Juan José López-Ibor Hospital Clínico San Carlos, Madrid G17 José Manuel Menchón Hospital Universitario de Bellvitge, Barcelona G22 Jerónimo Saiz Hospital Universitario Ramón y Cajal, Madrid 69

70

71 GroupS

72 2010 ANNUAL REPORT G01 Celso Arango López Hospital General Universitario Gregorio Marañón Unidad de Adolescentes. Dpto. de Psiquiatría C/ Dr. Esquerdo Madrid Phone: (+34) (+34) Fax: (+34) [email protected] Website: Group members Staff members Cintia Escandell García Jessica Merchán Naranjo Marta Leiva Resino Pamela Rodríguez Latorre Inmaculada Sanz Arrabal Cecilia Tapia Casellas Associate members David Fraguas Herráez Maria Luisa Giráldez Quiroga Joost Janssen Jeucken Mª Mayoral Aragón Luis Miguel Moreno Iñiguez Dolores Mª Moreno Pardillo Carmen Moreno Ruiz Mª José Parellada Redondo Marta Rapado Castro Santiago Reig Redondo Ana Mª Ruiz Sancho Lines of research Cognition in psychiatric disorders Neuropsychopharmacology of development First psychotic episodes Disorders of the autistic spectrum Collaborators Mar Álvarez Segura Azucena Corral Zarapuz Cloe Llorente Sarabia 72

73 Most relevant scientific articles in 2010 Rapado-Castro, M.; Soutullo, C.; Fraguas, D.; Arango, C.; Payá, B.; Castro-Fornieles, J.; González-Pinto, A.; Parellada, M.; Graell, M.; Baeza, I.; Bombin, I. Predominance of symptoms over time in early-onset psychosis: a principal component factor analysis of the Positive and Negative Syndrome Scale. Journal of Clinical Psychiatry, 71(3):327-37, Moreno, C.; Merchán-Naranjo, J.; Álvarez, M.; Baeza, I.; Alda, JA.; Martínez-Cantarero, C.; Parellada, M.; Sánchez, B.; de la Serna, E.; Giráldez, M.; Arango, C. Metabolic effects of secondgeneration antipsychotics in bipolar youth: Comparison with other psychotic and non-psychotic diagnoses. Bipolar Disorders, 12(2):172-84, Bobes, J.; Arango, C.; Rejas, J.; for the CLAMORS Study Collaborative Group. Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS Study. Journal of Clinical Psychiatry, 71(3):280-6, Most relevant innovations in 2010 Spanish validation of the diagnostic interview for depressive personality. Elaboration of the Guide to psychopharmacologic treatment of bipolar disorder for children and teenagers. Directorate General of Pharmacy, Regional Government of Madrid. Elaboration of the Good Practices Guide to deal with patients with Disorders of the Autistic Spectrum. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

74 2010 ANNUAL REPORT G02 Francesc Artigas Pérez Instituto de Investigaciones Biomédicas, CSIC-IDIBAPS Dpto. de Neuroquímica y Neurofarmacología C/ Roselló 161, 6ª planta Barcelona Phone: (+34) Fax: (+34) [email protected] Website: Group members Staff members María Jaramillo Muñumer Verónica Paz Silva Noemí Santana Ramos 74 Lines of research Neurobiological bases and treatment for severe psychiatric disorders: neurotransmitters, receptors, and brain circuits involved Action mechanism of antidepressant and antipsychotic psychoactive drugs: circuits involved Study on the brain circuits involved in the action of NMDA antagonists as schizophrenia models Neurobiological bases of new antidepressant strategies (deep brain stimulation, interference RNA) Neurochemistry and neuropharmacology of brain neurotransmission systems Associate members Albert Adell Calduch Analía Bortolozzi Biassoni Leticia Campa Montobbio Anna Castañé Forn Paz Celada Pedrosa Laura Jiménez Sanchez Mercè Masana Nadal Javier López Gil Laia Lladó Pelfort Mauricio Riga Collaborators Noemí Jurado Galán Giuseppe Mocci Tamara Romón Salinas Eva Troyano Rodríguez

75 Most relevant scientific articles in 2010 Lladó-Pelfort L.; Assié MB.; Newman-Tancredi A.; Artigas F.; Celada P. Preferential in vivo action of F15599, a novel 5-HT1A receptor agonist, at postsynaptic 5-HT1A receptors. British Journal of Pharmacology, 160: , 2010 Bortolozzi A.; Masana M.; Díaz-Mataix L.; Cortés R, Scorza MC.; Gingrich J.; Toth M.; Artigas F. Dopamine release Induced by atypical atipsychotics in prefrontal cortex requires 5-HT1A but not 5-HT2A receptors. The International Journal of Neuropsychopharmacology, 13: , 2010 Most relevant innovations in 2010 Combination of antidepressant drugs in the treatment of negative and cognitive symptomatology in schizophrenia. Use of interference RNA (sirna) techniques for genes selective annulment in the central nervous system. In the prefrontal cortex, identification of neurones sensitive to the action of atypical antipsychotic drugs. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

76 2010 ANNUAL REPORT G03 José Luis Ayuso Mateos Hospital Universitario de la Princesa C/ Diego de León Madrid Phone: (+34) Website: Group members Staff members María Cabello Salmerón Patricia Fernández Martín Roberto Nuevo Benítez Associate members Celia Anaya Suarez María Cabello Salmerón Luis Miguel García Olmos Pedro Gutierrez Recacha Matilde Hernández Álvarez Itziar Leal Leturia Almudena Martorell Cafranga Marta Miret García Amada Pereda Muñoz María del Mar Rivas Rodríguez Jesús Valle Fernández Lines of research Design and comparison of intervention strategies for affective disorders. Analysis of Europe s general health situation, life quality, welfare and ageing Nosology of mental and behavioural disorders Generation and prevention of suicidal behaviour in different socio-health contexts Functional affectation in neuro-psychiatric disorders 76

77 Most relevant scientific articles in 2010 Arana A.; Wentworth C.; Ayuso-Mateos JL.; Arellano F. Suicide-Related Events in Patients Treated with Antiepileptic Drugs. New England Journal of Medicine, 363: , 2010 Ayuso-Mateos JL.; Nuevo R.; Verdes E.; Naidoo N.; Chatterji S. From depressive symptoms to depressive disorders: the relevance of thresholds. British Journal of Psychiatry, 196(5):365-71, 2010 Garin O.; Ayuso-Mateos JL.; Almansa J.; Nieto-Moreno M.; Chatterji S.; Vilagut G, Alonso J.; Cieza A.; Svestkova O.; Burger H, Racca V.; Francescutti C.; Vieta E, Kostanjsek N.; Raggi A.; Leonardi M.; Ferrer M. Validation of the World Health Organization Disability Assessment Schedule (WHODAS-2) in patients with chronic diseases. Health and Quality of Life Outcomes, 19;8:51, 2010 Most relevant innovations in 2010 This research group has cooperated with the World Health Organization (WHO) on the development of a clinical guide to deal with mental disorders in environments that do not have a specific training on mental health. The Guide for mental, neurological and substance abuse disorders in non specialized settings was published by the WHO in The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

78 2010 ANNUAL REPORT G04 Miquel Bernardo Arroyo Hospital Clinic de Barcelona Servicio de Psiquiatría Villarroel 170, esc 9 pl Barcelona Phone: (+34) (ext. 3142) [email protected] Website: Group members Lines of research Physical Health and Schizophrenia Neuroimaging Genetics Neuropsychology Onset schizophrenia in children and adolescents Staff members Miguel Bioque Alcázar Claudia Cullell March Elena de la Serna Gómez Anna Folch Espada Ana Meseguer Albiach Associate members Susana Andrés Perpiñá Mª Inmaculada Baeza Pertegaz Bibiana Cabrera Llorca Rosa Calvo Escalona Josefina Castro Fornieles Rosa Catalán Campos Emilio Fernández Egea Amalia Lafuente Flo Luisa Lázaro García Francisco Lomeña Caballero Sergi Más Herrero Guillem Masana i Montejo Astrid Morer Liñan Eduardo Parellada Rodón Rafael Penadès Rubio Alexandre Pons Villanueva 78

79 Most relevant scientific articles in 2010 de la Serna E.; Baeza I.; Toro J.; Andrés S.; Puig O.; Sánchez-Guistau V.; Romero S.; Bernardo M.; Castro-Fornieles J. Relationship between clinical and neuropsychological characteristics in child and adolescent first degree relatives of subjects with schizophrenia. Schizophrenia Research, 116(2-3):159-67, 2010 Rametti G.; Junqué C.; Bartrés-Faz D.; Zubiaurre-Elorza L.; Catalán R.; Penadés R.; Bargalló N.; Bernardo M. Anterior cingulate and paracingulate sulcimorphology in patients with schizophrenia. Schizophrenia Research, 121(1-3):66-74, 2010 Most relevant innovations in 2010 SCIP-S scale (Screen for Cognetive Impairment in Psychiatry). A new tool for the assessment of the cognitive function of the psychiatric population. Spanish validation of BACS (Brief Assesment in Cognition in Schizophrenia) for patients with schizophrenia and healthy controls. Guide to clinical practice on attention deficit disorder with hyperactivity in children and adolescents. Coordinated by Agència d Avaluació de Tecnologia i Recerca Mèdiques (AATRM) The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

80 2010 ANNUAL REPORT G05 Julio Bobes García Universidad de Oviedo Dpto. de Medicina - Área de Psiquiatría Julián Clavería Oviedo Phone: (+34) Fax: (+34) [email protected] Website: Group members Staff members Susana Al- Halabí Díaz Mª Teresa Bascarán Fernández Eva Mª Díaz Mesa Marlén Garrido Menéndez Associate members Igor Bombín González Manuel Bousoño García José Ramón Fernández Hermida María Paz García-Portilla González Serafín Lemos Giráldez José Muñiz Fernández Pilar Alejandra Saiz Martínez Roberto Secades Villa Lines of research Cross lines (on subjects of interest applicable to all mental disorders): Genetics of mental and behavioural disorders: etiopathogenesis and secondary effects of psychopharmacologic treatment; Clinic: Cognitive dysfunction and Psychophisiology (sleeping and sexuality); Psychometrics: Development / Adaptation-Validation of tools of psychometric evaluation of mental and behaviour disorders; Neuroimaging; Physical comorbidity in mental and behavioural disorders; Treatment: Efficiency and tolerance of new psychoactive drugs or of new indications for already existing drugs and Efficiency of new strategies of psychological intervention; Impact of mental disorder and its treatment on patients lives: Performance (Impairment) and Quality of life Longitudinal lines (per disorder): Serious mental disorders (Schizophrenia and Bipolar Disorder) and their initial forms (first psychotic episodes), Unipolar depression; Suicide; Obsessive compulsive Disorder (OCD); Panic disorder; Addictions 80

81 Most relevant scientific articles in 2010 Bobes J.; Arango C.; Garcia-Garcia M.; Rejas J. Healthy lifestyle habits and 10-year cardiovascular risk in schizophrenia spectrum disorders: An analysis of the impact of smoking tobacco in the CLAMORS schizophrenia cohort Schizophrenia Research, 119: , 2010 Garcia-Portilla MP.; Sáiz PA.; Benabarre A.; Florez G.; Bascarán MT.; Diaz EM.; Bousoño M.; Bobes J. Impact of substance use on the physical health of patients with bipolar disorder. Acta Psychiatrica Scandinavica, 121: , 2010 Sáiz PA.; García-Portilla MP.; Arango C.; Morales B.; Arias B.; Corcoran P.; Fernández JM.; Alvarez V.; Coto E.; Bascarán MT.; Bousoño M.; Fañanas L.; Bobes J. Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study Progress. Neuro-Psychopharmacology & Biological Psychiatry, 34:26 31, 2010 Most relevant innovations in 2010 Development of markers for vulnerability risk in schizophrenia and in clinical severity for panic disorder. Providing Spanish professionals with a tool of sexual performance for peoples with severe mental disorder (schizophrenia and bipolar disorder): CSFQ-14 Fostering among psychiatrists the need to take responsibility for the patients general health and facilitating the calculation of risk of cardiovascular disease in people with severe mental disorders. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

82 2010 ANNUAL REPORT G06 Jorge A. Cervilla Ballesteros Universidad de Granada Dpto. Medicina Legal, Toxicología y Psiquiatría Facultad de Medicina Avda. de Madrid Granada Phone: (+34) (+34) [email protected] Website: Group members Staff members Ana Belén Cervilla Ballesteros Inmaculada Ibáñez Casas Katherine McKenney Mª Victoria Martín Laguna Esther Molina Rivas Associate members Blanca Gutiérrez Martínez Jose Antonio Lorente Acosta Francisco Torres González Lines of research Identification of psychotic phenotypes Genetic-environmental interaction in depression Social and community psychiatry 82

83 Most relevant scientific articles in 2010 Bottomley C.; Nazareth I.; Torres-González F.; Svab I, Maaroos HI.; Geerlings MI.; Xavier M, Saldivia S.; King M. Comparison of risk factors for the onset and maintenance of depression. BJP review of books, 196(1):13-7, 2010 Barrigón ML.; Gurpegui M.; Ruiz-Veguilla M.; Diaz FJ.; Anguita M, Sarramea F.; Cervilla J. Temporal relationship of first-episode non-affective psychosis with cannabis use: a clinical verification of an epidemiological hypothesis. Journal of psychiatric research, 44(7):413-20, 2010 Most relevant innovations in 2010 Quality Indicator for Rehabilitative Care (QuIRC): software tool to measure the life conditions, general quality of cares, and human rights of people with long lasting mental health problems in environments of psychiatric and social care facilities. predictd Web Site: Questionnaire designed as a tool to foresee the risk of future depression. Setting up criteria for the use of coercive measures throughout the psychiatric hospitalization and in the transfer to the hospital. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

84 2010 ANNUAL REPORT G07 Manuel Desco Menéndez Hospital General Universitario Gregorio Marañón Laboratorio de Imagen Médica Unidad de Medicina y Cirugía Experimental Dr. Esquerdo Madrid Phone: (+34) Fax: (+34) [email protected] Website: Group members Staff members Verónica García Vázquez Rosa Trajana Garrido Huerta José María Mateos Pérez Associate members Felipe Calvo Manuel Pedro Luís Dominguez Montero Pedro García Barreno Juan Guzmán de Villoria Lebiedziejewski Javier Lafuente Martínez Javier Pascau González-Garzón Juan Antonio Santos Miranda Mª Luisa Soto Montenegro Santiago Reig Redondo Collaborators Marina Benito Vicente Alejandra de Francisco López Lines of research Technological development and magnetic resonance technology Cardiac imaging and Experimental molecular imaging Neuroimaging Image processing Support and clinical research 84

85 Most relevant scientific articles in 2010 M Michaelides, J Pascau, JD Gispert, F Delis, DK Grandy, GJ Wang, M Desco, M Rubinstein, ND Volkow, PK Thanos. Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate. Eur J Neurosci, 32: , 2010 E Lage, JL Villena, G Tapias, NP Martínez, ML Soto-Montenegro, M Abella, A Sisniega, F Pino, D Ros, J Pavía, M Desco, JJ Vaquero. A SPECT Scanner for Rodent Imaging Based on Small-Area Gamma Cameras. IEEE T Nucl Sci, 57(5): , 2010 Most relevant innovations in 2010 Updating for fmri studies, development, and maintenance of the server in order to have a centralized storage and processing of data via the web for studies carried out in different centres. Installation of tools for an advanced quantification and a statistical analysis of the anatomic characteristics of the cerebral sulcus and gyrus as psychosis markers. Development of methods to process molecular images in small animals. Sequences for fmri studies with electric stimuli. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

86 2010 ANNUAL REPORT G08 Lourdes Fañanás Saura Universidad de Barcelona Unidad de Antropología Dpto. de Biología Animal Facultad de Biología Avda. Diagonal 645, 2ª planta Barcelona Phone: (+34) Group members Staff members Bárbara Arias Sampériz Mar Fatjó-Vilas Mestre María José Martín García Sandra Tallón Paredes Anna María Valdeperas Llaberia Helen Vossen Associate members Sergi Papiol Miro Araceli Rosa de la Cruz Collaborators Mª Carmen Aguilera Ruiz Silvia Alemany Sierra Ximena Goldberg Hermo Nadia Vilahur Chiaraviaglio Lines of research Consolidated quality group (SGR827) Genes and environment in the understanding of the diversity of human behaviour and of etiopathogenesis of mental disease Identification of genetic risk factors in functional psychosis both of infantile-juvenile and adult origin: analysis of endophenotypes based on psychopathologic dimensions, neurocognition, and neuroimaging Study on the interaction of genes-environment on twins Genetic studies, studies on cerebral dysfunction and on clinical phenotypes in disorders of the schizophrenic and autistic spectrum Pharmacogenetics of antidpressants and antipsychotics 86

87 Most relevant scientific articles in 2010 Pomarol E.; Fatjó-Vilas M.; Mc Kenna P.; Monté G.; Sarró S.; Ortiz-Gil J.; Aguirre C.; Gomar J.; Guerrero A.; Landin R.; Capdevila A.; Fañanás L.; Raymond S. Join First Authorship Comt Val158met Polymorphism In Relation To Activation And De-Activation In The Prefrontal Cortex: A Study In Patients With Schizophrenia And Healthy Subjects. Neuroimage, 15;53(3): , 2010 Sáiz P.; García-Portilla M.; Arango C.; Morales B.; Arias B.; Corcoran P.; Fernández JM.; Alvarez V.; Coto E.; Bascarán MT.; Bousoño M.; Fañanas L.; Bobes J. Genetic Polymorphisms In The Dopamine-2 Receptor (Drd2), Dopamine-3 Receptor (Drd3), And Dopamine Transporter (Slc6a3) Genes In Schizophrenia: Data From An Association Study. Progress In Neuropsychopharmacology And Biological Psychiatry, 34:26-31, 2010 Arias B.; Fatjó-Vilas M.; Papiol S.; Rosa A.; Alemany S.; Goldberg X.; Vilahur N.; Fañanás L. Towards The Understanding Of The Genetic Complexity Of Functional Psychoses. European Journal Of Psychiatry, 23, Supl:49-55, 2010 Most relevant innovations in 2010 Twins register UB - Marie Curie EUTwinsS to research on mental diseases. Pharmacogenetic applications for the antipsychotics and antidepressants treatment. Innovations in knowledge: identification of CNV genetic variation and mechanisms of phenotype expression in functional psychosis. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

88 2010 ANNUAL REPORT G09 Javier Garzón Niño Instituto Cajal CSIC Avenida Doctor Arce, Madrid Phone: (+34) Website: Group members Staff members Zoraida Escalona García Beatriz Fraile Méndez Beatriz Martín Aznar María Rodríguez Muñoz Associate members Concha Bailón Prieto María Pilar Sánchez Blázquez Collaborators Carmelo Isidoro Aguado García de Marina Ana Vicente Sánchez Lines of research Neuropsychopharmacology Study on the physical association between the G receptors implied in schizophrenia and depression (D2, D1, CB1R, 5HT1A, 5HT2A) and the NMDA receptors at the prefrontal cortex. Implication in the action mechanism of drugs Identification of Signaling Proteins as vulnerability markers in mental illness and drug addiction (HINT1-Akt/GSK3-βcatenina; HINT1-Akt-nNOS-NO-Zinc). Tolerance mechanisms for psychoactive drugs Animal models for the study of mental illnesses. Generation and pharmacological study on animal models for depression/schizophrenia. HINT1 and RGSZ2 knockout. NMDAR subunits knockdown Alterations of the NMDAR glutamatergic function in depression and schizophrenia. Redox signaling in the pathophysiology of schizophrenia 88

89 Most relevant scientific articles in 2010 Sánchez-Blázquez P.; Rodríguez-Muñoz M.; Garzón J. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One, 5(6):e11278, 2010 Most relevant innovations in 2010 Generation of polyclonal antibodies against the receptors involved in mental disorders. Generation of knock-down animals for signaling proteins involved in mental diseases. Development of the Proteomic Analysis Platform. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

90 2010 ANNUAL REPORT G10 Ana Mª González-Pinto Arrillaga Hospital Santiago Apóstol Olaguibel, Vitoria-Gasteiz Phone: (+34) Group members Lines of research Study on biomarkers and pharmacogenetics in affective disorders and schizophrenia Neurocognition and psychological interventions in first psychotic episodes and bipolar disorder Neuroimaging in first psychotic episodes and Alzheimer Neuropsychopharmacology: pre and post-authorization clinical trials Oxidation and inflammation in first psychotic episodes Staff members Susana Alberich Mesa Sara Barbeito Resa Mónica Martínez Cengotitabengoa Associate members Marta Alonso Pinedo Enrique Aragües Ortiz de Zarate Ariadna Besga Basterra María Echebeste Portugal Maria Blanca Fernández de Corres Aguiriano Rubén González Oliveros Asunción González-Pinto Arillaga Margarita Herranz Manrique Mahmoud Karim Haidar María Begoña Mendivil Eguiluz Luis Pacheco Yáñez María del Carmen Romera de la Fuente Santiago Ron Martín Sonia Ruiz de Azúa Margarita Sáenz Herrero Amaia Ugarte Ugarte Collaborators Ana Aldama Juárez Enrique Echeburúa Odriozola Javier Gil Goikouria Cristina González Gómez Jon Irazusta Astiazaran Manuel Martín Carrasco María Purificación López Peña José Luis Pérez de Heredia Flores Fernando Ramírez Ortiz Patricia Vega Pérez

91 Most relevant scientific articles in 2010 Isasi AG.; Echeburúa E.; Limiñana JM.; González-Pinto A. How effective is a psychological intervention program for patients with refractory bipolar disorder? A randomized controlled trial. Journal of Affective Disorders. 126(1-2):80-7, 2010 Most relevant innovations in 2010 Review of psychological treatments in first psychotic episodes. Health Tecnologies evaluation report, Osteba. Vitoria. Validation scales of hypomania detection: Hamilton 5 and MES FAST validation scale The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

92 2010 ANNUAL REPORT G11 Josep Maria Haro Abad Parc Sanitari Sant Joan de Déu Dr. Antoni Pujades, 42 Edificio Docente Sant Boi de Llobregat (Barcelona) Phone: (+34) Website: Group members Staff members Adriana Berengueras Gallego Janina Carlson Aburto Elena Huerta Ramos Iria Meléndez Pérez Beatriz Olaya Guzmán Belén Ramos Josemaría Miriam Romeu Hernández Esther Urgell Golvano María Victoria Villalta Gil 92 Lines of research Clinical subtypes and perception and attention processes Genomics and proteomics Epidemiology Mental health interventions Child psychiatry Associate members Susana Araya la Rivera Belén Arranz Martí Joaquín Balsera Gómez Jordan Bertsch Gildas Brébion Montserrat Dolz Abadia Alexandrina Foix Sanjuan Susana Ochoa Güerre Juan Francisco Roldán Merino Luis San Molina Judith Usall i Rodié Collaborators Iris Baños Yeste Aida Farreny Seró Raquel Iniesta Bededicto Raquel López Carrilero Ferrán Marsá Sambola Christian Stephan-Otto Attolini Mercedes Roca Casasús

93 Most relevant scientific articles in 2010 Borges G.; Nock MK.; Haro JM.; Hwang I.; Sampson NA.; Alonso J.; Andrade LH.; Angermeyer MC.; Beautrais A.; Bromet E.; Bruffaerts R.; De Girolamo G.; Florescu S.; Gureje O.; Hu C.; Karam EG.; Kovess V.; Lee S.; Levinson D.; Medina Mora ME.; Ormel J.; Posada Villa J.; Sagar R.; Tomov T.; Uda H.; Williams DR.; Kessler RC. Twelve-month prevalence of and risk factors for suicide attempts in the world health organization world mental health surveys. The Journal of Clinical Psychiatry, 71(12): , 2010 Bruffaerts R.; Demyttenaere K.; Borges G.; Haro JM.; Chiu WT.; Hwang I.; Karam EG.; Kessler RC.; Sampson N.; Alonso J.; Andrade LH.; Angermeyer MC.; Benjet C.; Bromet E.; De Girolamo G.; De Graaf R.; Florescu S.; Gureje O.; Horiguchi I.; Hu C.; Kovess V.; Levinson D.; Posada Villa J.; Sagar R.; Scott K.; Tsang A.;Vassilev SM.; Williams DR.; Nock MK. Childhood adversities as risk factors for onset and persistence of suicidal behaviour. British Journal of Psychiatry, 197(1):20-7, 2010 Novick D.; Haro JM.; Bertsch J.; Haddad PM. Incidence of Extrapyramidal Symptoms and Tardive Dyskinesia in Schizophrenia: Thirty-Six-Month Results From the European Schizophrenia Outpatient Health Outcomes Study. Journal of Clinical Psychopharmacology, 30(5):531-40, 2010 Most relevant innovations in 2010 Development and validation of a scale to assess the insight in affective disorders. Evaluation of raloxifene, a partial estrogen agonist in the schizophrenia treatment. Guide to Clinical Practice on Attention Deficit Disorder with Hyperactivity (ADDH) in Children and Adolescents. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

94 2010 ANNUAL REPORT G12 Juan Carlos Leza Cerro Universidad Complutense de Madrid Dpto. Farmacología. Facultad de Medicina Avda. Complutense s/n Madrid Phone: (+34) Website: Group members Staff members Borja García Bueno Karina S. MacDowell Mata Silvia Zoppi Associate members Beatriz Gómez Pérez-Nievas Jose Luis Muñoz Madrigal Collaborators Icíar Gárate Pérez Lines of research Search for inflammatory biomarkers in patients with neuropsychiatric disease in order to identify and develop new therapeutic strategies Study of protection mechanisms against oxidative and inflammatory cellular damage after exposure to stress. Identification of possible therapeutic targets and evaluation of anti-inflammatory strategies, including anti-depressant and anti-psychotic drugs in animal models (in vivo and in vitro) of psychiatric disease Study of colonic bacterial translocation induced by stress in the cerebral response to stress Assessment of the therapeutic potential of the endocannabinoid system in neuropsychiatric pathologies provoked by stress Possible new mechanisms: role of the innate immune receptors (TLRs) in stress-related processes in models of neuropsychiatric pathologies (depression) 94

95 Most relevant scientific articles in 2010 García Bueno B.; Pérez-Nievas BG.; Leza JC. Is there a role for the nuclear receptor PPARgamma in neuro-psychiatric diseases?.the International Journal of Neuropsychopharmacology, 13(10): , 2010 Madrigal JLM.; García Bueno B.; Hinojosa AE.; Polak P.; Feinstein DL.; Leza JC. Regulation of MCP-1 production in brain by stress and noradrenaline modulating drugs. Journal of Neurochemistry, 113(2):543-51, 2010 Pérez-Nievas BG.; García Bueno B.; Madrigal JLM.; Leza JC. Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated. Journal of Neurochemistry, 7;7:60, 2010 The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

96 2010 ANNUAL REPORT G13 Antonio Lobo Satué Area Coordinator of Other Mental Disorders Hospital Clínico Universitario Lozano Blesa, planta 3 Avda. San Juan Bosco Zaragoza Phone: (+34) [email protected] Website: Group members Lines of research Staff members Olga Ibáñez Raúl López Antón Juan Francisco Roy Delgado Javier Santabárbara Serrano Associate members Mª Fe Barcones Molero Antonio Jesús Campayo Martínez Concepción de la Cámara Izquierdo José Luis Día Sahún Leticia Beatriz Gutiérrez Galve Elena Lobo Escolar Guillermo Marcos Aragüés Juan Francisco Roy Delgado Pedro Saz Muñoz Tirso Ventura Faci New research tendencies in psychiatry Psychogeriatrics Psychosomatics and Liaison Psychiatry Psychic and somatic comorbidity 96

97 Most relevant scientific articles in 2010 Lobo E.; Dufouil C.; Marcos G.; Quetglas B.; Saz P.; Guallar E.; Lobo A. For the ZARADEMP Workgroup. Is There an Association Between Low-to-Moderate Alcohol Consumption and Risk of Cognitive Decline? American Journal of Epidemiology, 172(6): , 2010 Gutiérrez-Galve L.; Wheeler-Kingshott CA.; Altmann DR.; Price G.; Chu EM.; Leeson VC.; Lobo A.; Barker GJ.; Barnes TR.; Joyce EM.; Ron MA. Changes in the Frontotemporal Cortex and Cognitive Correlates in First-Episode Psychosis. Biological Psychiatry, 68(1):51-60, 2010 Campayo A.; de Jonge P.; Roy JF.; Saz P.; de la Cámara C.; Quintanilla MA.; Marcos G.; Lobo A. Depressive disorder and incident diabetes: The effect of characteristics of depression. The American Journal of Psychiatry,167(5): , 2010 Most relevant innovations in 2010 INTERMED, a genuine method for the early detection of complex patients (due to medical, psychiatric comorbidity, use of services and social difficulties). The Spanish version has been standardized and validated and we are working along with international groups. The INTERMED system can provide epidemiologic and public health applications. First identification of clinically significant depression (psychiatric diagnostic) as a factor for diabetes risk. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

98 2010 ANNUAL REPORT G14 Juan José López-Ibor Aliño Hospital Clínico San Carlos Instituto de Psiquiatría y Salud Mental Prof. Martín Lagos s/n Madrid Phone: (+34) Fax: (+34) [email protected] Group members Lines of research Brain functioning anomalies in personality impulsive disorders Study on neurobiological anomalies in feeding behaviour disorders Study on neurobiological anomalies in first psychotic episodes Study on endophenotypes in personality impulsive disorders Study on genetic and neuroendocrinological factors Staff members Camila Bayón Palomina Rafael Fernández García-Andrade Cristina López Mico Nerea Palomares Mora Rocío Arza Pascual Juan Matías Santos García Associate members Juan Arrazola García Ana Barabash Bustelo Jose Antonio Cabranes Diaz Jose Luis Carrasco Perera Julia del Río Vega Marina Díaz Marsá Alberto Fernández Lucas María Inés López-Ibor Alcocer Tomás Ortiz Alonso Blanca Reneses Prieto Mª Dolores Saiz González 98

99 Most relevant scientific articles in 2010 Boter H.; Derks EM.; Fleischhacker WW.; Davidson M.; Kahn RS. EUFEST Study Group, Generalizability of the results of efficacy trials in first-episode schizophrenia: comparisons between subgroups of participants of the European First Episode Schizophrenia Trial (EUFEST). The Journal of Clinical Psychiatry, 71(1):58-65, 2010 Derks EM.; Fleischhacker WW.; Boter H.; Peuskens J.; Kahn RS. EUFEST Study Group. Antipsychotic drug treatment in first-episode psychosis: should patients be switched to a different antipsychotic drug after 2, 4, or 6 weeks of nonresponse? Journal of Clinical Psychopharmacology, 30(2):176-80, 2010 Castellanos NP.; Paúl N.; Ordóñez VE.; Demuynck O.; Bajo R.; Campo P.; Bilbao A.; Ortiz T.; del-pozo F.; Maestú F. Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury. Brain : a journal of neurology, 133(8): , 2010 Most relevant innovations in 2010 Clinical process in severe personality disorders: assessment and clinical treatment by processes in severe personality disorders. Process of neurocognitive rehabilitation in personality disorders: systematized assessment and neuropsychological rehabilitation in patients with personality disorders. Clinical process of feeding reeducation in feeding behaviour disorders: therapeutic dining room for female patients suffering from any kind of feeding behaviour disorder. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

100 2010 ANNUAL REPORT G15 Peter J. McKenna Benito Menni Complejo Asistencial en Salud Mental Unidad de Investigación Benito Menni CASM Dr. Antonio Pujadas Barcelona Phone: (+34) (ext. 486) - Fax: (+34) [email protected] Website: Group members Staff members María Anguera Camós Erick J. Canales Rodríguez Jesús Joaquín Gomar Soñes Bárbara Segura Fábregas Gemma C. Monté Rubio Eulàlia Porta Felipe Joaquín Radua Castaño Pilar Salgado Pineda Associate members Benedikt Amann Edith Pomarol Clotet Raymond Salvador Civil Salvador Sarró Maluquer Lines of research Collaborators Jordi Ortiz Gil Development of new methods of analyzing NMR in psychiatry. Functional brain connectivity in psychosis Multi-modal studies on Neuroimaging in first psychotic episodes, in schizophrenia, schizoaffective disorder and in bipolar disorder Development and validation of new therapeutic strategies for the treatment of cognitive deficits Relationship between abnormalities of the brain s structure and function and clinical aspects in psychotic disorders 100

101 Most relevant scientific articles in 2010 Pomarol-Clotet E, Canales-Rodriguez EJ, Salvador R, Sarro S, Gomar JJ, Vila F, Ortiz-Gil J, Iturria-Medina Y, Capdevila A, McKenna PJ. Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Molecular Psychiatry, 15: , 2010 Salvador R, Sarro S, Gomar JJ, Ortiz-Gil J, Vila F, Capdevila A, Bullmore E, McKenna PJ, Pomarol-Clotet E. Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia. Human Brain Mapping, 31: , 2010 Pomarol-Clotet E, Fatjo-Vilas M, McKenna PJ, Monte GC, Sarro S, Ortiz-Gil J, Aguirre C, Gomar JJ, Guerrero A, Landin R, Capdevila A, Fananas L, Salvador R. COMT Val158Met polymorphism in relation to activation and de-activation in the prefrontal cortex: A study in patients with schizophrenia and healthy subjects. Neuroimage, 53: , 2010 Most relevant innovations in 2010 Technical advances in neuroimaging: Brain connectivity: new multi-variant version of the analysis method of brain connectivity drawing from images of functional resonance at rest. Diffusion (DTI): Implantation of a measurement sequence of diffusion images of angular high resolution magnetic resonance on a hemisphere; implantation and validation of a filtering and deconvolution technique for magnetic resonance images of diffusion spectrum. Validation of the scale WAT (Word Accentuation Test) to evaluate premorbid intellectual capacity in schizophrenia. Study on the usefulness of cognitive stimulation in schizophrenia. Evaluation of the possible superiority of cognitive stimulation in schizophrenia over the effects of other non specific interventions in cognition. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

102 2010 ANNUAL REPORT G16 José Javier Meana Martínez Universidad del País Vasco Facultad de Medicina y Odontología Dpto. Farmacología Bº Sarriena s/n Leioa - Bizkaia Phone: (+34) Fax: (+34) [email protected] Website: Group members Lines of research Therapeutical interventions in mental health Neuropsychopharmacology First psychotic episodes: prognostic, diagnostic, and predictive factors in the evolution of the illness Biological markers in psychiatric illnesses and their treatment Staff members Leire Corada Galarreta Rebeca Díez Alarcia Eva Munarriz Cueva Natalia Ojeda del Pozo Borja Santos Zorrozúa Associate members Francisco Javier Ballesteros Rodríguez Sergio Barrondo Lakarra Luis Felipe Callado Hernando Rebeca Diez Alarcia Amaia Maite Erdozain Fernández Ane Miren Gabilondo Urkijo Miguel Gutiérrez Fraile Igor Horrillo Furundarena Idoia Martín Guerrero Maider López de Jesus Jorge Emilio Ortega Calvo Joan Salles Alvira Leyre Uriguen Echevarria Collaborators Harkaitz Imaz Etxebarria Leire Echeazarra Escudero Iñaki Eguíluz Uruchurtu Edorta Elizagarate Zabala Itziar Gil de La Pisa Mario Montaña Muro Carolina Muguruza Millán Javier Palomo Lertxundi Imanol Querejeta Ayerdi Rafael Segarra Echebarría Aranztazu Zabala Rabadán

103 Most relevant scientific articles in 2010 Valdizán EM.; Díez-Alarcia R.; González-Maeso J.; Pilar-Cuéllar F.; García-Sevilla JA.; Meana JJ.; Pazos. A. α2-adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims. Biol Psychiatry, 1;68(9):869-72, 2010 Ortega JE.; Fernández-Pastor B.; Callado LF.; Meana JJ. In vivo potentiation of reboxetine and citalopram effect on extracellular noradrenaline in rat brain by α(2)-adrenoceptor antagonism. Eur Neuropsychopharmacol, 20(11):813-22, 2010 Most relevant innovations in 2010 Guide on the treatment of opiate addiction with Buprenorfine/Naloxone. Clinical guide Therapeutic strategies for refractory schizophrenia or schizophrenia resistant to treatment. Clinical guide Psycho-educative guide on first psychotic episodes. Clinical guide The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

104 2010 ANNUAL REPORT G17 José Manuel Menchón Magriñá Hospital Universitari de Bellvitge Feixa Llarga, s/n L Hospitalet de Llobregat (Barcelona) Phone: (+34) [email protected] Website: Group members Staff members Blanca Bueno Juliá-Campany Alba Gálvez Ortiz Marina López Sola Antonio Soto López Associate members Mª del Pino Alonso Ortega Narcis Cardoner Alvarez Fernando Contreras Fernández Jose Manuel Crespo Blanco Mikel Urretavizcaya Sarachaga Julio Vallejo Ruiloba Lines of research Schizophrenia Obsessive compulsive disorder Mood disorders Neuroimaging 104

105 Most relevant scientific articles in 2010 Segalàs C, Alonso P, Real E, Garcia A, Miñambres A, Labad J, Pertusa A, Bueno B, Jiménez-Murcia S, Menchón JM. Memory and strategic processing in first-degree relatives of obsessive compulsive patients. Psychological Medicine, 40(12): , 2010 López-Solà M, Pujol J, Hernández-Ribas R, Harrison BJ, Ortiz H, Soriano-Mas C, Deus J, Menchón JM, Vallejo J, Cardoner N. Dynamic assessment of the right lateral frontal cortex response to painful stimulation. Neuroimage, 15;50(3): , 2010 Alonso P, Segalàs C, Real E, Pertusa A, Labad J, Jiménez-Murcia S, Jaurrieta N, Bueno B, Vallejo J, Menchón JM. Suicide in patients treated for obsessive-compulsive disorder: a prospective follow-up study. Journal of Affective Disorders, 124(3):300-8, 2010 Most relevant innovations in 2010 Implementation of deep cerebral stimulation for the treatment of severe, chronic and refractory obsessive compulsive disorder. Two-dimensional and three-dimensional analysis of cerebral deformation. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

106 2010 ANNUAL REPORT G18 Juan Antonio Micó Segura Facultad de Medicina Universidad de Cádiz Plaza Fragela Cádiz Phone: (+34) [email protected] Website: tidepresivosydolor.areastematicas.com Group members Staff members Laura Pérez Caballero Raquel Rey Brea Patricia Miranda Azpiazu Clara Muñoz Mediavilla Mª Carmen Romero Grimaldi Montserrat Sanz Aguilar Associate members Esther Berrocoso Domínguez Lidia Bravo García Juan Gibert Rahola Lines of research Collaborators Cristina Alba Delgado Jesús Gallego Gamo Sonia Torres Sánchez Study of the neurobiological relationship between depression and pain Research on biomarkers in schizophrenia, depression, and bipolar disorder Research and development of experimental models of mental illnesses and chronic pain Research and development of neuropsychodrugs 106

107 Most relevant scientific articles in 2010 Agüera L, Failde I, Cervilla J, Díaz-Fernández P. Medically unexplained pain complaints are associated with underlying unrecognized mood disorders in primary care. BMC Fam Pract.,11:17, 2010; NE Vergel NE; Lopez JL, Orallo F, Viña D, Buitrago DM, Del Olmo E, Mico JA, Guerrero MF. Antidepressant-like profile and MAO-A inhibitory activity of 4-propyl-2H-benzo[h]-chromen-2-one. Life Science, 86(21-22):819-24, 2010 Most relevant innovations in 2010 Use of ADAM-17 inhibitor in neuronal regeneration. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

108 2010 ANNUAL REPORT G19 Tomás Palomo Álvarez Hospital Universitario 12 de Octubre Glorieta de Málaga s/n Madrid Phone: (+34) Website: Group members Lines of research Vulnerability to schizophrenia. Cognitive function. Disorder evolution Schizophrenia treatment. First episodes. Treatment of resistant symptoms Psychotic disorders. Dual psychosis and pathology. Addictive disorders Personality. Features and disorders. Attention deficit disorder and hyperactivity. Conduct disorder Psychosomatics. Psychiatric morbidity in medical-surgical patients. Demographic psychiatric morbidity and use of aid resources Staff members Elena Garrido Fernández María del Carmen Gómez Núñez Beatriz Gómez Pérez-Nievas Noelia Guerra Martin-Polanco Adolfo Quiñones Lombraña Associate members Francisco Javier Sanz Fuentenebro Gabriel Rubio Valladolid Guillermo Ponce Alfaro Janet Hoenicka Luis Fernando Agüera Ortiz María Aragüés Figuero María Isabel Martínez Gras Miguel Ángel Jiménez-Arriero Roberto Rodríguez-Jiménez Vicente Molina Rodríguez Collaborators Alexandra Bagney Lifante Laura España Serrano Cristina García Navarro Rosa Jurado Barba Mercedes Navío Acosta 108

109 Most relevant scientific articles in 2010 Hoenicka J, Quiñones-Lombraña A, España-Serrano L, Alvira-Botero X, Kremer L, Pérez- González R, Rodríguez-Jiménez R, Jiménez-Arriero MA, Ponce G, Palomo T. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Biological Psychiatry, 67(1):3-11, 2010 Rodriguez-Jimenez R, Bagney A, Martinez-Gras I, Ponce G, Sanchez-Morla EM, Aragües M, Rubio G, Jimenez-Arriero MA, Santos JL, Palomo T, PARG Executive function in schizophrenia: influence of substance use disorder history. Schizophrenia Research, 118(1-3):34-40, 2010 Hoenicka J, Garrido E, Martínez I, Ponce G, Aragüés M, Rodríguez-Jiménez R, España-Serrano L, Alvira-Botero X, Santos JL, Rubio G, Jiménez-Arriero MA, Palomo T, PARG. Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the official publication of the International Society of Psychiatric Genetics, 153B(1):79-85, 2010 Most relevant innovations in 2010 The group G19 (in collaboration with group G13, MR A. Lobo) ended the development, standardization, and collection of normative data related to Spanish population for the MATRICS Consensus Cognitive Battery (MCCB). These tasks were done in cooperation with Michael Green and Keith Nuechterlein, coordinators of the Neurocognition Committee of the Measurement and Treatment Research to Improv Cognition in Schizophrenia (MATRICS), within the National Institute of Mental Health (U.S.A.). Development of the use of the inhibition technique of the prepulse of the startle reflex in patients with first psychotic episode without cannabis consumption. Study on the use of clozapine in first psychotic episodes. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

110 2010 ANNUAL REPORT G20 Angel A. Pazos Carro Universidad de Cantabria Av. Herrera Oria s/n Santander Phone: (+34) Fax: (+34) [email protected] Website: Group members Staff members Helena Blanco Gómez Mª Fuencisla Pilar Cuellar Begoña Treceño Dalmau Associate members Elena Castro Fernandez Alvaro M. Díaz Martínez Eva Marrón Souto Antonio Rodríguez Gaztelumendi Mª Luisa Rojo Antuña Elsa M. Valdizan Ruiz Rebeca Vidal Casado Lines of research Collaborators Jesús Pascual Brazo Verónica Vargas Modulation of brain neuroproliferation and neuroplasticity pathways as a mechanism for antidepressant pharmacologic action Modifications of the aminergic and brain cannabinoid receptors in depression: postmortem studies Neuroplasticity and schizophrenia Analgesic actions of antidepressants Studies on the pharmacogenetics of intracellular proteins involved in the etiopathogenesis of mental illnesses 110

111 Most relevant scientific articles in 2010 Vidal R, Valdizan EM, Vilaró MT, Pazos A, Castro ME. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats. British Journal of Pharmacology,161(3): , 2010 Tramullas M, Lantero A, Díaz A, Morchon N, Merino D, Villar A, Buscher D, Merino R, Hurle J, Izpisua- Belmonte JC, Hurle M. J. BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. The Journal of Neuroscience, 30(4): , 2010 Valdizán EM, Díez-Alarcia R, González-Maeso J, Pilar-Cuéllar F, García-Sevilla JA, Meana JJ, Pazos A. Biol. α2-adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims. Biological Psychiatry, 68(9): , 2010 Most relevant innovations in 2010 Creation of a scientific support technical document for reports on interactions between drugs that might be of interest for the results of a genotyping DNA chip that shapes the polymorphisms involved in the metabolism of neuro-pharmaceuticals. Participation in the pre-clinical assessment of molecular candidates to be developed as antidepressants by using a coordinated platform of pharmacological, biochemical, and molecular studies on the cellular proliferation of the nervous system. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

112 2010 ANNUAL REPORT G21 Víctor Pérez Solá Depression Area Coordinator Hospital de la Santa Creu i Sant Pau Servicio de Psiquiatría Sant Antoni Mª Claret, Barcelona Phone: (+34) Fax: (+34) [email protected] Website: Group members Staff members Saiko Allende Leal Eva M. Grasa Bello Maria J. Portella Moll Thaïs Tiana Sastre Collaborators Mª Rosa Ballester Verneda Ignasi Gich Saladich Sergio Romero Lafuente Associate members Enrique Álvarez Martínez Rosa M. Antonijoan Arbós Manuel José Barbanoj Rodríguez Ana María Catafau Alcantara Susana Clos Batet Iluminada Corripio Collado Sandra Giménez Badia Juan Carlos Pascual Mateos Josefina Pérez Blanco Dolors Puigdemont Campos Jordi Riba Serrano Joaquín Soler Ribaudi Marta Valle Cano Lines of research Affective disorders: application of new therapeutic tools in resistant DM; studies on structural and functional neuroimaging; biological and genetic markers; identification and assessment of new therapeutic targets; new therapeutic programmes, assessment and social aspects of DM Psychotic disorders: study on environmental, biological, and genetic factors; studies on the efficacity and efficiency of antipsychotic drugs; studies on first episodes; genotype-phenotype interaction and environment; neuroimaging. Personality disorders: clinical trials on the usefulness of the joint treatment of patients with BPD and validation of diagnostic tools; studies on genetics-neuroimaging Mental health therapeutics: efficiency-resistance to treatment; systematic checkups Neuropsychopharmacology: clinical trials during the early stages (stage I, II); studies on neuropsychopharmacology; use of predictive mathematical models in pharmacology 112

113 Most relevant scientific articles in 2010 Soria V, Martínez-Amorós E, Escaramís G, Valero J, Pérez-Egea R, García C, Gutiérrez-Zotes A, Puigdemont D, Bayés M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Pérez V, Menchón JM, Estivill X, Gratacòs M, Urretavizcaya M. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology, 35(6): , 2010 Alonso JF, Mañanas MA, Romero S, Hoyer D, Riba J, Barbanoj MJ. Drug effect on EEG connectivity assessed by linear and nonlinear couplings. Human Brain Mapping, 31(3):487-97, 2010 Most relevant innovations in 2010 Study on the pioneer technique of Deep Cerebral Stimulation for depression treatment in patients with Bipolar Disorder and PET exam in diagnosed depressed patients. Examination of the glycine type 1 transporter (GlyT-1) and of the glutamatergic system through PET and its involvement in the pathogenesis of schizophrenia. Studies on first depressive episodes: MR study and telomere length. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

114 2010 ANNUAL REPORT G22 Jerónimo Saiz Ruiz Hospital Universitario Ramón y Cajal Ctra. Colmenar Km 9, Madrid Phone: (+34) Fax: (+34) [email protected] Website: Group members Lines of research Staff members Analucía Alegria Alzamora Rosa María de Almeida Nunes Beatriz Grillo Durán Sandra Elisa Isella Rodolfo Estévez Fernández Mario de Prado Cumplido Associate members Antonio Artes Rodríguez Enrique Baca García Manuel Antonio Ceverino Domínguez María Carmen Díaz Sastre Ángela Ibáñez Cuadrado Adrián Llerena Ruiz José Manuel Montes Rodríguez María de las Mercedes Pérez Rodríguez Genetics of mental disorders and pharmacogenetics Itineraries in Public Services of Mental Health Psychotic disorders: first episodes. Environmental, biological, and genetic factors Obsessive-compulsive disorcer Impulse control disorders and suicidal behaviour 114

115 Most relevant scientific articles in 2010 Baca-Garcia E, Vaquero-Lorenzo C, Perez-Rodriguez MM, Gratacòs M, Bayés M, Santiago-Mozos R, Leiva-Murillo JM, de Prado-Cumplido M, Artes-Rodriguez A, Ceverino A, Diaz-Sastre C, Fernandez- Navarro P, Costas J, Fernandez-Piqueras J, Diaz-Hernandez M, de Leon J, Baca-Baldomero E, Saiz- Ruiz J, Mann JJ, Parsey RV, Carracedo A, Estivill X, Oquendo MA. Nucleotide variation in central nervous system genes among male suicide attempters. American Journal of Medical Genetics B Neuropsychiatr Genet, 153B(1):208-13, 2010 Baca-Garcia E, Perez-Rodriguez MM, Keyes KM, Oquendo MA, Hasin DS, Grant BF, Blanco C. Suicidal ideation and suicide attempts in the United States: and Molecular Psychiatry, 15(3):250-9, 2010 Most relevant innovations in 2010 Use of machine learning techniques in the study of gene-gene interaction in suicidal conduct. Studies on the suicide attempts tendencies in epidemiologic data bases. First description in the field s literature on the relation to polymorphism of CYP2D6 pharmacogenetics in patients with feeding behaviour disorders. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

116 2010 ANNUAL REPORT G23 Julio Sanjuán Arias Schizophrenia Area Coordinator Universidad de Valencia Facultad of Medicina Avda. Blasco Ibáñez, Valencia Phone: (+34) Web: Group members Staff members Sabrina Cruz Romaguera Gracián García Martí José Luis Ivorra Martínez Blanca Llácer Iborra Inmaculada Pérez Roda Enrique Vila Romero Collaborators Mª Teresa Bobes Bascarán Olga Brotons Girona Mª José Escartí Fabra Javier Gilabert Juan Manuel Jover Martínez Esther Lorente Rovira Lines of research Identification of risk polymorphisms in psychosis (with special attention to auditory hallucinations) Epigenetic studies (functional expression) of candidate genes in psychosis. Identification of genetic-environmental risk factors in affective and psychotic disorders Identification of neuroimaging abnormal patterns (morphometry, functional, spectroscopy) in psychotic patients Design and coordination of clinical, genetic and neuroimaging data bases to carry out multiple centre projects Associate members Eduardo J. Aguilar García-Iturrospe José Miguel Carot Sierra Rosa de Frutos Illán Marien Gadea Domenech José Carlos González Piqueras Neus Herrero Sebastián Carmen Leal Cercós María Dolores Moltó Ruíz David Moratal Pérez Carmen Nájera Montes Olga Rivero Martín Mª Amparo Tolosa Toledo 116

117 Most relevant scientific articles in 2010 Albacar G, Sans T, Martín-Santos R, García-Esteve L, Guillamat R, Sanjuan J,Cañellas F, Carot JM, Gratacòs M, Bosch J, Gaviria A, Labad A, Zotes AG, Vilella E. Thyroid function 48h after delivery as a marker for subsequent postpartum depression. Psychoneuroendocrinology, 35(5):738-42, 2010 Escartí MJ, de la Iglesia-Vayá M, Martí-Bonmatí L, Robles M, Carbonell J, LullJJ, García-Martí G, Manjón JV, Aguilar EJ, Aleman A, Sanjuán J. Increasedamygdala and parahippocampal gyrus activation in schizophrenic patients withauditory hallucinations: an fmri study using independent component analysis. Schizophrenia Research, 117(1):31-41, 2010 Rivero O, Reif A, Sanjuán J, Moltó MD, Kittel-Schneider S, Nájera C, Töpner T,Lesch KP. Impact of the AHI1 gene on the vulnerability to schizophrenia: acase-control association study. PLoS One, 5(8): e12254, 2010 Most relevant innovations in 2010 Use of fmri to measure the cognitive therapy efficiency in psychotic hallucinations. Use of a new algorithm for the pharmacological treatment of auditory hallucinations. The Hospital Clínico de Valencia started a reference unit for first psychotic episodes. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

118 2010 ANNUAL REPORT G24 Rafael Tabarés Seisdedos Universidad de Valencia Avda. Blasco Ibañez, Valencia Phone: (+34) Fax: (+34) [email protected] Website: Website: Group members Staff members Olga Bahamonde Ponce Patricia Correa Ghysais Teresa Escámez Matínez Associate members Vicent Balanza Martínez Emilio Geijo Barrientos Manuel Gómez Beneyto Cristina Rubio Rodríguez José Salazar Fraile Gabriel Selva Vera Lourdes Valdés Sánchez Lines of research Experimental embryology Study of cognitive endophenotypes (Endophenocognitypes) Study of negative comorbidity Epidemiological study Longitudinal study of schizophrenia and bipolar disorder I Clinical genetics Neurogenetics 118

119 Most relevant scientific articles in 2010 Balanzá-Martínez V, Selva G, Martínez-Arán A, Prickaerts J, Salazar J, González-Pinto A, Vieta E, Tabarés-Seisdedos R. Neurocognition in bipolar disorders--a closer look at comorbidities and medications. European Journal of Pharmacology, 626(1):87-96, 2010 Girón M, Fernández-Yañez A, Mañá-Alvarenga S, Molina-Habas A, Nolasco A, Gómez-Beneyto M. Efficacy and effectiveness of individual family intervention on social and clinical functioning and family burden in severe schizophrenia: a 2-year randomized controlled study. Psychological Medicine, 40(1):73-84, 2010 Selva-Vera G, Balanzá-Martínez V, Salazar-Fraile J, Sánchez-Moreno J, Martinez-Aran A, Correa P, Vieta E, Tabarés-Seisdedos R. The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia. BMC Psychiatry, 10:47, 2010 Most relevant innovations in 2010 Innocampus-vlc/campus. International excellence programme of the Ministry of Science and Innovation: development of the micro-cluster personal autonomy, dependence, and severe mental disorders. Design of genomic and complementary DNA sequences to be used in the molecular diagnostic of nervous system pathologies provoked by alterations of the genes lis1, ywhae, tusc5 and myo1c. Alterations in these genes may result in Miller-Dieker syndrome, cortical dysplasia, mental retardation, retardation in movement development and other kinds of neurological and neuropsychiatric pathologies. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

120 2010 ANNUAL REPORT G25 Eduard Vieta Pascual Coordinator of the Bipolar Disorder Area Hospital Clinic de Barcelona C/ Villarroel 170, Esc 9 Planta Barcelona Phone: (+34) (ext. 2310) - Fax: (+34) [email protected] Website: Group members Lines of research Epidemiology and disability related to bipolar and unipolar disorders Endophenotypes, genetics, and biomarkers in affective disorders Clinical trials and innovation in psychopharmacology for bipolar and depressive disorders Innovative psychological interventions in bipolar disorder Neurocognition and neuroimaging of bipolar and unipolar disorders Staff members Carolina Franco Porras Pere Castellví Obiols Nuria Cruz Culebra Isabella Pacchiarotti Maria Reinares Gagneten Jose Sanchez Moreno Carla Torrent Font Associate members Antonio Benabarre Hernández Jordi Blanch Andreu Francesc Colom Victoriano Cristobal Gastó Ferrer Jose Manuel Goikolea Alberdi Teodor Marcos Bars Anabel Martínez Aran Rocío Martin-Santos Leffon Victor Navarro Odriozola Collaborators Mercè Comes Forastero 120

121 Most relevant scientific articles in 2010 López-Jaramillo C, Lopera-Vásquez J, Gallo A, Ospina-Duque J, Bell V, Torrent C, Martínez-Arán A, Vieta E. Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence. Bipolar Disorders, 12(5): , 2010 Vieta E, de Arce R, Jiménez-Arriero MA, Rodriguez A, Balanzá V, Cobaleda S, SIN-DEPRES Group. Detection of subclinical depression in bipolar disorder: a cross-sectional, 4-month prospective followup study at community mental health services (SIN-DEPRES). The Journal of Clinical Psychiatry, 71(11): , 2010 Gómez-Gil E, Navinés R, Martínez De Osaba MJ, Díaz-Ricart M, Escolar G, Salamero M, Martín-Santos R, Galán A, Gastó C. Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment. Psychoneuroendocrinology, 35(4): , 2010 Most relevant innovations in 2010 Development of a new antagonistic dopaminergic-setononergic drug for the treatment of acute mania. Elaboration of an international guide to clinical practice and treatment of bipolar depression to be followed in health systems. Creation and development of a guide to deal specifically with bipolar disorder in Catalonia. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

122 2010 ANNUAL REPORT G26 José Luis Vázquez Barquero Hospital Universitario Marqués de Valdecilla Avenida de Valdecilla s/n Santander Phone: (+34) Website: Group members Staff members Rosa Ayesa Arriola Ignacio Mata Pastor Víctor Ortiz García de la Foz Roberto Roiz Santiáñez Associate members Benedicto Crespo Facorro Luis Gaite Pindado José Andrés Herrán Gómez Sara Herrera Castanedo José María Pelayo Terán Rocío Pérez Iglesias José Manuel Rodríguez Sánchez Collaborators Diana Tordesillas Gutiérrez Lines of research First episodes of Non-affective Psychosis: clinical and biological aspects Cerebral neuroimaging: development of methods Psychiatric epidemiology and services assessment 122

123 Most relevant scientific articles in 2010 Mata I, Perez-Iglesias R, Roiz-Santiañez R, Tordesillas-Gutierrez D, Gonzalez-Mandly A, Berja A, Vazquez-Barquero Jl, Crespo-Facorro B. Additive Effect Of Nrg1 And Disc1 Genes On Lateral Ventricle Enlargement In First Episode Schizophrenia. Neuroimage, 53(3): , 2010 Pérez-Iglesias R, Tordesillas-Gutiérrez D, Mcguire Pk, Barker Gj, Roiz-Santiañez R, Mata I, De Lucas Em, Rodríguez-Sánchez Jm, Ayesa-Arriola R, Vazquez-Barquero Jl, Crespo-Facorro B. White Matter Integrity And Cognitive ImpairmeNt In First-Episode Psychosis. The American Journal of Psychiatry, 167(4):451-8, 2010 Rodríguez-Sánchez Jm, Ayesa-Arriola R, Mata I, Moreno-Calle T, Perez-Iglesias R, González-Blanch C, Periañez Ja, Vazquez-Barquero Jl, Crespo-Facorro B. Cannabis Use And Cognitive Functioning In First- Episode Schizophrenia Patients. Schizophrenia Research, 124(1-3):142-51, 2010 Most relevant innovations in 2010 Mental Health Map of Cantabria, in cooperation with the Health Department of the Government of Cantabria, for Mental Health Strategies of the National Health System, (SNS, Sistema Nacional de Salud) by the Ministry of Health and Social Policy. Psychoeducational Guide for Families with Psychotic Diagnosed Members, in cooperation with the General Directorate of Health Ordination, Inspection and Care, Health Department of the Government of Cantabria. The group in figures Published articles: Articles published in the first quartile: Cumulative impact factor: Projects:

124 Sponsored by the 4th National Plan for R+D+I and by the initiative Ingenio 2010, programme Consolider, CIBER Actions. CIBERSAM comply with the requirements of the standard ISO 9001:2008 Coordination: Sara García Rodríguez (CIBERSAM Communication) Supervision: Celso Arango (Scientific Director of CIBERSAM) and Miquel Bernardo Arroyo (CIBERSAM Coordinator of Institutional Relations) Graphic design: Selecpicur S.L., Servicios Editoriales Printing: Impresiones Generales S.A. LD: GI-703/2009 April 2011 Cover photograph: Composición por Selecpicur, S.L. Photographs: CIBERSAM files, Stock.XCHNG, fotolia and Selecpicur files Unión Europea Centro de Investigación Biomédica En Red de Salud Mental Instituto de Salud Carlos III Fondo Europeo de Desarrollo Regional Una manera de hacer Europa

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126 Centro de Investigación Biomédica En Red de Salud Mental Hospital Gral. Universitario Gregorio Marañón Pabellón de Gobierno - first floor C/ Dr. Esquerdo 46 (entrance on Ibiza street) Madrid Spain [email protected] Phone: (+34) FAX: (+34) Unión Europea Instituto de Salud Carlos III Fondo Europeo de Desarrollo Regional Una manera de hacer Europa