Cord Blood Banking: worldwide overview
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1 Cord Blood Banking: worldwide overview Joan García a MD PhD
2 Public Public CB Banks mission To collect, store and supply CB units with the highest quality and safety To improve the probability of finding suitable HP donors To promote the clinical use of CB. To promote research on biology and clinical application of CB
3 New York CBB: the pioneer The New York CBB is the first integrated program for cord blood banking and transplant: THE NATIONAL CORD BLOOD PROGRAM. It has produced a number of crucial papers on the biology, processing and transplant of placental cells. Inventory including more than 40,000 units More than 2700 transplants performed Associated to, NMDP, BMDW and NETCORD
4 Individual cord blood banks cannot accomplish their mission alone Networks at national and international level: one step ahead Purpose: Share inventory and requests Maintain international standards Augment and simplify communications with transplant centres Further collaborations among banks Promote and advocate for cord blood
5 Auscord Auscord is one of the first CBBs integrated program. The CBBs of the Australian program are situated in the Sydney Children s Hospital; the Royal Children s Hospital, Melbourne and in the Mater Misericordiae Hospital in Brisbane Inventory including more than 18,000 units More than 378 transplants performed Their communication systems acts through the Australian Bone Marrow Donors Registry. Associated to BMDW and NETCORD
6 Belgium CBB program It operates through the Belgium Cord Blood Registry and includes three CBBs: Brussels, Gant and Liege. Inventory including more than 6500 units More than 200 transplants performed Associated to NETCORD and FACT/NETCORD accredited Leuvencord is an independent program with an inventory of 8000 units and more than 104 transplants Associated to NETCORD
7 FRANCE CORD Is a single CBB program with a central coordination in Paris and other three operational locations: Besançon on,, Bordeaux and Annemasse (storage centre) Overal inventory includes more than 6500 units More than 700 transplants performed Associated to NETCORD and BMDW The whole French unrelated donors activity has been integrated in the recently created Agence de la Biomedicine. France Cord program has adopted the FACT/Netcord standards and, Besançon CBB is accredited.
8 Germany CBBs programs: Dueseldorf (Pioneer and CO founder of Netcord, developing and supporting the concept of Virtual Office) and Manheim, Gauting, (Germany CORD). Overal inventory includes more than units More than 600 transplants performed Associated to NETCORD. BMDW. Germany Cord Duesseldorf: José Carreras Cord Blood Bank Program is one of the first FACT/NETCORD Accredited CBB..
9 The Italian network First embryo on 1996 under the leadership of the Milano Cord Blood bank Pioneer of the concept of cord blood inventories networking under a single quality assurance system (ISO 9000) The current Italian Network includes the 16 Italian active pubblic CBBs in a single network managed by IBMDR: Treviso, Padova, Milano, Torino, Pavia, Bologna, Genova,Firenze, Pisa, Lazio (Roma La Sapienza e Roma Tor Vergata), Roma Università Cattolica, Pescara, Napoli, Reggio Calabria, Verona) The current inventory includes more than CBUs More than 650 units transplanted The Milano CBB has been one of the NETCORD founders and one of the first to obtain the FACT/NETCORD accreditation. Collaboration with NETCORD, BMDW
10 Israel Programs Tel Hassomer (Sheba) and Hadassa Blood Bank. One of the earliest programs. The current inventory includes 1385 and 3312 stored CBUs, respectively. 31 units transplanted Collaboration with NETCORD, BMDW, NMDP
11 The NMDP Cord Blood Program The USA National Marrow Donor Program has developed a network of 23 USA and non USA CBBs : San Diego CA, Denver CO, Durham CN, Orange CA, Altamonte Springs FL, Glenview IL, Detroit MI, Gainesville FL, Houston TX, Camden NJ, Seattle WA, Tel Hashomer (Israel), St. Louis MO, Arcadia CA, LinKou (Taiwan), San Antonio TX, Orlando FL and Allendale NJ, Singapore, Sheba CBB (Israel), Taiwan CBB... Current inventory: more than 87,000 units >2200 CBU have been delivered for transplant. Accreditation: AABB and FACT/NETCORD Operation through NMDP search system (in addition to 8M MUD) Associated to 171 USA and non USA transplant centers. NMDP / NETCORD agreement Arcadia, Durham and Houston have already obtained the FACT/NETCORD accreditation. Appointment for management of the Bill Young National CB program
12 UK Programs NHS London Cord Blood Bank. One of the earliest programs, co founder of Netcord. Inventory including more than 9500 units More than 220 transplants performed Associated to NETCORD and FACT/NETCORD accredited The Antony Nolan Registry has launched a CBB program on 2008
13 The Spanish Network: Six regional CBBs and 11 donation programs: Barcelona (Catalonia, Balears, Aragon, Navarra, Extremadura), Madrid, Malaga (Andalucia, Castilla La Mancha), Santiago, Tenerife, Valencia. PESCU recently aproved It includes more than 30,000 stored CBU more than 650 transplanted. Barcelona CBB has been one of the NETCORD founders. Málaga and Santiago CBB are NETCORD members. They operate in collaboration with the Spanish BMD registry: REDMO
14 Single site National Programs Eurocord Netherlands (Leiden) 3505 stored units 63 CBT Czechia Cord (Prague) 2899 stored units 22 CBT Finland (Helsinki) 2856 stored units 17 CBT Hellenic CBB (Athens) 560 stored units 5 CBT Switzerland Cord 1925 stored units Mexico (CordMx) 1029 stored units 72 CBT SwedCord 250 stored units
15 The Asian network: Founded in November 2000 in Bangkok It includes the major CBB in Asia: Beijing, Tianjin, Seoul,Taipei, Ho Chi Minh, Bangkok and Tokyo. Organization based on NETCORD statutes and standards. Operated through an electronic search system. Rapidly increasing inventory. Updated data from Taipei units stored and JCBBN: units stored and more than 4384 transplants generated. The Tokyo CBB is the more active one with 5710 units stored 740 transplants performed.
16 BMDW Pioneer organization on the procurement of unrelated donors for hemopoietic transplants founded on 1988, central offices in Leiden. Voluntary collaborative effort with the goal to provide centralised information on the HLA and other relevant data of unrelated stem cell donors and cord blood units Internal search algorithm based on the HLA typing of patients lists potential donors and their location. Participants: 58 stem cell donor registries from 43 countries, and 38 cord blood banks from 21 countries. The current number of donors and cord blood units : over 12,000,000 and 400,000, respectively
17 EUROCORD is an international registry on behalf of the European Blood and Marrow Transplant group (EBMT), including European and non European centres. EUROCORD collaborates with CBBs by validation of data and sending statistical analysis of the cord blood transplants performed with their respective units to every associated CBBs EUROCORD registry based analysis has developed crucial reports supporting the concept of establishing cryopreserved cord blood banks for clinical use.
18 International NETCORD Foundation
19 A bit of history The International NetCord Foundation 1995: Genesis in Milano, Duesseldorf, Barcelona, Paris, London, New York, Tokio, Leiden, Denver. 1998: Founding of organization 2000: Legally established as a foundation, chartered in Leiden, The Netherlands 2001: Virtual Office opened in Duesseldorf 2004: Executive Office opened in Chicago 2006: Re organized with new Bylaws and strategic plan 2006: Concluded a first search agreement with NMDP 2007: Second generation of officers and directors
20 MISSION To globally unite supply and demand for umbilical cord blood. To promote the highest quality cord blood products through worldwide standards and an accreditation process for cord blood banks. To encourage and facilitate expanded uses of cord blood transplants by promoting laboratory and clinical research, as well as treatment outcome evaluation.
21 NETCORD Officers President Joan Garcia (Barcelona) Vice President Elizabeth Shpall (Houston) Secretary Eliane Gluckman (Paris) Treasurer Yves Beguin (Liege) Immediate Past President Peter Wernet (Düsseldorf) Directors Riitta Kekomäki (Helskinki) Paolo Rebulla (Milano) Pablo Rubinstein (New York) Joan Kurtzberg (Durham) Cristina Navarrete (London) Markus Vowels (Sidney) Honorary Directors José Carreras Girolamo Sirchia Marcela Contreras International Councillors Ciril Rozman (Barcelona) Jon van Rood (Leiden) Managing Director Alan Leahigh (Chicago) Virtual Office Director Holger Gressmann (Düsseldorf)
22 NETCORD Achievements NetCord/FACT Standards Accreditation program Search and procurement program: The Virtual Office Contribution to key scientific papers Participation of >30 cord blood banks More than 300 transplant centers Strategic plan Collaboration with the NMDP Virtual office
23 NetCord FACT Standards Goals To promote quality practices: maternal and donor selection, screening, and testing cord blood collection, process, testing, banking, selection, release, and transport. To consistently assure provision of quality CB units To permit research and development
24 FACT/NetCord Accredited Cord Blood Banks Total CBB Applicants 57 (Applicants in US, UK, Europe, Asia) ACCREDITED 15 Source: org & factwebsite.org
25
26 ONGOING AND FUTURE ACTIONS Educational programs Research programs Marketing and promotional communications Enhance communications with transplant centers Strength relationships with other organizations Collaboration with NMDP to create a global registry
27 Issues to be adressed in the next future
28 CB Inventory must continue growing Histocompatibility implications Currently stored units:»~ 400,000»~ 100 CBBs Units on accredited CBBs (15):»~ 200,000 (<50 %, > 1X10 9 NC)
29 Continue promoting quality on CBBs Profile of Transplanted units: implications Barcelona CBB data: Cellular content of stored and transplanted units 12, Stored Transplanted ,7 6,9 NC x 10e8 CD34 x 10e6 Barcelona CBB data: Evolution of cellular and progenitors content of transplanted units 4 2 Storage of < 30% of collected units Larger collection programs
30 Summary
31 Acknowledgments: AsiaCord Auscord Cordbloodbank of Bayerische Stammzellbank ggmbh Eurocod Eurocord Netherland. Leiden Hadassa MDA/ Israel CBB Hellenic CBB. Athens. Jose Carreras CBB Düsseldorf Milano Cord Blood Bank National Cord Blood Program. NY. Nationella biobanken för navelsträngsblod. Swedcord Netcord Foundation NHS London Cord Blood Bank National Marrow Donor Registry Programa SCU. Andalucia Programa Nacional de Sangre placentaria CordMx REDMO Sheba CBB Tokio CBB
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