Foundational Issues in Biomedical Ontologies
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1 San Francisco September 9, 2004 Foundational Issues in Biomedical Ontologies Workshop Olivier Bodenreider Lister Hill National Center for Biomedical Communications Bethesda, Maryland - USA
2 4. The proper treatment of is-a, part-of and other foundational relations and of top-level categories such as function, role, process, structure, activity
3 Biomedical vocabularies vs. Biomedical ontologies Biomedical vocabularies Objective: information retrieval Thesaurus model Hierarchies: parent/child, broader/narrower than Not every relation is labeled Not every relationship is precisely defined Biomedical ontologies Objective: inference, reasoning Ontology model Hierarchies: hierarchical relationships Every relation is labeled Every relationship is precisely defined 3
4 Thesaurus relationships Alcohol Ethanol Alcoholism 4
5 Imprecise definition of relationships Endocrine disease is a Autoimmune disease is generally a Addison s disease is a Tuberculous Addison s disease 5
6 Hierarchies vs. Hierarchical relations Acetaminophen Tylenol Tylenol Acetaminophen Acetaminophen Tylenol 6
7 5. The proper treatment of classes and instances (including prototypical, variant and borderline instances)
8 Classes vs. Instances What Classes Represent Have Kinds of things [Abstractions] Instances (mandatorily( mandatorily) Subclasses (possibly) Have vertical relations Superclass of subclass Has instance instance Have horizontal relations to other classes Instances Represent The things themselves Have vertical relations Is instance of Class NB: an instance cannot have instances Have horizontal relations to other instances 8
9 Classes vs. Instances Where Biomedical terminologies and ontologies contain mostly classes Exceptions: few geographical areas, laws, persons Column names in databases, field names in forms Clinical databases and micro-array experiments contain instances Values in databases can be either classes or instances 9
10 Classes vs. Instances A fine-grained class does not make it an instance A leaf cannot be either a class or an instance Subclass of: : Relationship between classes Is instance of: : Relationship between an instance and a class In some systems, it does not matter whether leaf classes are implemented as subclasses or as instances 10
11 6. The proper treatment of epistemological concepts such as finding, measurement, and test results in medical ontologies
12 Ontology vs. Epistemology Ontology What exists (in reality) Regardless of how we know it Regardless of modality Epistemology What exists, through How we came into being it existed Modality Breast cancer Probable breast cancer Breast cancer detected during a routine mammography 12
13 Epistemology in Biomedicine Epistemology is everywhere Beside the diagnosis, doctors may record how they came to the diagnosis To explain of the diagnostic strategy For accountability reasons Incomplete, most probable diagnosis 13
14 Epistemology in biomedical terminology Epistemological features built in terms Skull fracture with intracranial hemorrhage Skull fracture without intracranial hemorrhage Presence/absence intracranial hemorrhage May change the course of the disease of which skull fracture is a part Does not change the skull fracture itself Clinical terminology systems have to provide epistemological features 14
15 Epistemology in biomedical ontology Biomedical ontologies do NOT have to provide epistemological features But clinical terminology services based on bioledical ontologies would have to If epistemological features are present in biomedical ontologies,, they should be clearly recorded as such Epistemology must be recognized as something important by the biomedical ontology community 15
16 Unresolved issues What constitutes a biomedical class? Classes defined as the complement of other classes Non-insulin dependent diabetes mellitus Not otherwise specified is to be banned What about Not elsewhere classified? What is biomedical reality? What is normality? 16
17 Medical Ontology Research Contact: Web: mor.nlm.nih.gov Olivier Bodenreider Lister Hill National Center for Biomedical Communications Bethesda, Maryland - USA
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