Division of Hospital Infection)

Transcription

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5 -Antimicrobial Agents and Chemotherapy American Society for Microbiology (ASM) -Journal of Antimicrobial Chemotherapy British Society of Antimicrobial Chemotherapy (BSAC) -Journal of Clinical Microbiology American Society for Microbiology (ASM) -Applied and Environmental Microbiology American Society for Microbiology (ASM) -FEMS Microbiology Letters Federation of European Microbiological Societies (FEMS) -Emerging Infectious Diseases Centers for Disease Control and Prevention (CDC) -International Journal of Antimicrobial Agents European Society f Chemotherapy (ESC) -Clinical Microbiology and Infection European Society of Clinical Microbiology and Infectious Diseases (ESCMID) -Future Microbiology Future Medicine - ( ) ( ). ) ISI : 143 ISI : 6 : 4 : 11 : 50 : 60 (IF): IF: 608,7 IF: 4,26 (citations)* : ISI, SCI Expanded, ScienceDirect & Scopus.

6 ISI 1. MENTIS A, TZOUVELEKIS L, MAVROMMATI L. Susceptibility of fifteen Chlamydia trachomatis strains isolated in Greece. Journal of Antimicrobial Chemotherapy 1989; 24: , LEGAKIS N, TZOUVELEKIS L, MAKRIS A, KOTSIFAKI H. Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin. Antimicrobial Agents and Chemotherapy 1989; 33: , TZOUVELEKIS L, TUMAH H, MALLIARA K, LEGAKIS N. Relationship of antibiotic resistance phenotype to R-pyocin susceptibility pattern in clinical isolates of Pseudomonas aeruginosa. Journal of Chemotherapy 1989; 1: , VATOPOULOS A, PHILIPPON A, TZOUVELEKIS L, KOMNINOU Z, LEGAKIS N. Prevalence of a transferable SHV-5 type -lactamase in clinical isolates of Klebsiella pneumoniae and Escherichia coli in Greece. Journal of Antimicrobial Chemotherapy 1990; 26: ,068 4a. MENTIS A, TZOUVELEKIS L, SPILIADIS C, BLACKWELL C, WEIR D. Inhibition of Helicobacter pylori haemagglutination activity by human salivary mucins. Microbiology Immunology (FEMS) 1990; 64: , TZOUVELEKIS LS, MENTIS AF, MAKRIS A, SPILIADIS C, BLACKWELL C, WEIR D. In vitro binding of Helicobacter pylori to human gastric mucin. Infection and Immunity 1991; 59: µ 72 4, VATOPOULOS AC, TSAKRIS A, TZOUVELEKIS LS, LEGAKIS NJ, PITT TL, MILLER GH, SHAW KJ, ANTREOU M, NIKOLOPOULOU M, KOMNINOU Z. "Diversity of aminoglycoside resistance in Enterobacter cloacae in Greece". European Journal of Clinical Microbiology and Infectious Diseases 1992; 11: , TSAKRIS A, VATOPOULOS AC, JOHNSON AP, PITT TL, LEGAKIS NJ, TZOUVELEKIS LS. "Prevalence of a plasmid-mediated type II dihydrofolate reductase gene among trimethoprim-resistant urinary pathogens in Greek hospitals". Journal of Antimicrobial Chemotherapy 1992; 29:

7 5, TZELEPI E, TZOUVELEKIS LS, VATOPOULOS AC, MENTIS AF, TSAKRIS A, LEGAKIS NJ. "High prevalence of stably derepressed class-i -lactamase expression in multiresistant clinical isolates of Enterobacter cloacae from Greek hospitals". Journal of Medical Microbiology 1992; 37: , TZOUVELEKIS LS, TZELEPI E, MENTIS AF, VATOPOULOS AC, TSAKRIS A. "Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability". FEMS Microbiology Letters 1992; 95: , TZOUVELEKIS LS, MENTIS AF, TZELEPI E, TSAKRIS A, KYRIAKIS K, LEGAKIS NJ. "Exposure effects of netilmicin on Enterobacter cloacae clinical isolates". Chemotherapy 1992; 38: µ µ 1 1,816 10a.TSAKRIS A, VATOPOULOS A, TZOUVELEKIS L, LEGAKIS N. Diversity of resistance phenotypes and plasmid analysis in multiresistant O:12 Pseudomonas aeruginosa. European Journal of Epidemiology 1992; 8: , TSAKRIS A, JOHNSON AP, LEGAKIS NJ, TZOUVELEKIS LS. "Prevalence of the type I and type II DHFR genes in trimethoprim-resistant urinary isolates of Escherichia coli from Greece". Journal of Antimicrobial Chemotherapy 1993; 31: , TZOUVELEKIS LS, TZELEPI E, MENTIS AF, TSAKRIS A. "Identification of a novel plasmid-mediated -lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae". Journal of Antimicrobial Chemotherapy 1993; 31: , LEGAKIS NJ, TZOUVELEKIS LS, TSAKRIS A, LEGAKIS JN, VATOPOULOS AC. "On the incidence of antibiotic resistance among aerobic gram-negative rods isolated in Greek hospitals". Journal of Hospital Infection 1993; 24: , HEISIG P, TZOUVELEKIS LS, VATOPOULOS AS, LEGAKIS NJ. Ciprofloxacin resistance in enterobacterial clinical isolates. Journal of Antimicrobial Chemotherapy 1993; 33: , TZOUVELEKIS LS, TZELEPI E, KAUFMANN ME, MENTIS A. Consecutive mutations leading to the in vivo emergence of imipenem resistance in a clinical strain of Enterobacter aerogenes. Journal of Medical Microbiology 1994; 40:

8 21 2, TZOUVELEKIS LS, TZELEPI E, MENTIS AF. Nucleotide sequence of a plasmid- mediated cephalosporinase gene (blalat-1) found in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy 1994; 38: , GIANELLI D, TZELEPI E, TZOUVELEKIS LS, MENTIS AF, NICOLOPOULOU C. Dissemination of cephalosporin resistant Serratia marcescens strains producing a plasmidic SHV type -lactamase in Greek hospitals. European Journal of Clinical Microbiology and Infectious Diseases 1994; 13: , DOUBOYAS J, TZOUVELEKIS LS, TSAKRIS A. "In-vitro activity of ampicillin/sulbactam against multiresistant Acinetobacter calcoaceticus var. anitratus clinical isolates". Journal of Antimicrobial Chemotherapy 1994; 34: , LEGAKIS NJ, TZOUVELEKIS LS, HATZOUDIS G, TZELEPI E, GOURKOU A, PITT TL, VATOPOULOS AC. Dissemination of plasmids encoding an SHV-5 type beta- lactamase among Klebsiella pneumoniae strains isolated in Greek hospitals. Journal of Hospital Infection 1995; 31: , LEGAKIS NJ, MANIATIS A, TZOUVELEKIS LS. Prevalent mechanisms of resistance among enterobacteria isolated in Greek hospitals. Microbial Drug Resistance 1996; 1: ,153 20a.TZOUVELEKIS LS, TZELEPI E, MENTIS AF, LEGAKIS NJ. Activity of cefpirome against selected clinical enterobacterial isolates with -lactamase-mediated resistance. Infection 1995; 23: , TZOUVELEKIS LS, PRINARAKIS E, GAZOULI M, MIRIAGOU V, TZELEPI E, LEGAKIS NJ. In vitro activity of cefetamet against enterobacteria expressing an SHV-5 type -lactamase. Chemotherapy 1996; 42: , PRINARAKIS E, TZELEPI E, GAZOULI M, MENTIS AF, TZOUVELEKIS LS. Characterization of a novel SHV -lactamase variant that resembles the SHV-5 enzyme. FEMS Microbiology Letters 1996; 139: , GEORGOPOULOS S, MENTIS AF, SPILIADIS CA, TZOUVELEKIS LS, TZELEPI E, MOSHOPOULOS A, SKANDALIS N. Helicobacter pylori infection in spouses of patients with

9 duodenal ulcers and comparison of ribosomal RNA gene patterns. Gut 1996; 39: µ 69 10, GAZOULI M, TZOUVELEKIS LS, PRINARAKIS E, TZELEPI E. Transferable cefoxitin resistance in enterobacteria isolated in Greek hospitals and characterization of a plasmid-mediated group 1 -lactamase (LAT-2). Antimicrobial Agents and Chemotherapy 1996; 40: , GAZOULI M, KAUFMANN M, TZELEPI E, DIMOPOULOU H, PANIARA O, TZOUVELEKIS LS. Study of an outbreak of cefoxitin-resistant Klebsiella pneumoniae in a general hospital. Journal of Clinical Microbiology 1997; 35: , TZOUVELEKIS LS, GAZOULI M, PRINARAKIS EE, TZELEPI E, LEGAKIS NJ. Comparative evaluation of the inhibitory activities of the novel penicillanic acid sulfone Ro against - lactamases that belong to groups 1, 2b, and 2be. Antimicrobial Agents and Chemotherapy 1997; 41: , PRINARAKIS E, MIRIAGOU V, TZELEPI E, GAZOULI M, TZOUVELEKIS LS. Emergence of an inhibitor-resistant -lactamase (SHV-10) derived from an SHV-5 variant. Antimicrobial Agents and Chemotherapy 1997; 41: µ 85 4, TZOUVELEKIS LS, ZISSIS NP, GAZOULI M, TZELEPI E, LEGAKIS NJ. In vitro comparative assessment of -lactamase inhibitors and their penicillin combinations against selected enterobacteria. International Journal of Antimicrobial Agents 1997; 8: , TZELEPI E, AVGERINOU H, KYRIAKIS K, TZOUVELEKIS LS, FLEMETAKIS A, KALOGEROPOULOU A, FRANGOULI E. Antimicrobial susceptibility and types of Neisseria gonorrhoeae in Greece. Data from the four-year period Sexually Transmitted Diseases 1997; 24: µ 15 2,873 29a.TSAKRIS A, TZOUVELEKIS LS, DOUBOYAS J, PANAGEA T, TZELEPI E. Diversity of - lactamases among Klebsiella pneumoniae strains isolated in a university hospital. European Journal of Epidemiology 1997; 13: , GAZOULI M, SIDORENKO S, TZELEPI E, KOZLOVA N, GLADIN NP, TZOUVELEKIS LS. A plasmid-mediated -lactamase conferring resistance to cefotaxime in a clone of Salmonella typhimurium found in St.-Petersburg, Russia. Journal of Antimicrobial Chemotherapy 1997; 41:

10 µ 30 5, TSAKRIS A, DOUBOYAS J, TZOUVELEKIS LS. High rates of resistance to piperacillintazobactam among Escherichia coli and Klebsiella pneumoniae strains isolated in a Greek hospital. Diagnostic Microbiology and Infectious Diseases 1997; 28: , TZOUVELEKIS LS, TZELEPI E, PRINARAKIS E, GAZOULI M, KATRAHOURA A, GIAKKOUPI P, PANIARA O, LEGAKIS NJ. Sporadic emergence of cefepime and cefpirome resistant Klebsiella pneumoniae strains in Greek hospitals. Journal of Clinical Microbiology 1998; 36: , GIAKKOUPI P, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Substitution of Arg-244 for Cys or Ser in SHV-1 and SHV-5 -lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes. FEMS Microbiology Letters 1998; 160: µ 8 2, GAZOULI M, TZELEPI E, SIDORENKO SV, TZOUVELEKIS LS. Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A -lactamase (CTX- M-4): involvement of serine 237 in cephalosporin hydrolysis. Antimicrobial Agents and Chemotherapy 1998; 42: µ 74 4, GIAKKOUPI P, MIRIAGOU V, GAZOULI M, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Properties of mutant SHV-5 -lactamases constructed by substitution of Met to Ile or Val at position 69. Antimicrobial Agents and Chemotherapy 1998; 42: µ 8 4, TZOUVELEKIS LS, TZELEPI E, MANIATIS A, VOGIATZAKIS E, PANIARA O, TSELENTIS Y, LEGAKIS NJ. Amoxicillin-clavulanate resistance as related to - lactamase content in Escherichia coli strains from community acquired urinary tract infections. Clinical Microbiology and Infection 1998; 4: , PRINARAKIS EE, TZOUVELEKIS LS, LEGAKIS NJ. Activity of loracarbef against TEM extendedspectrum -lactamase-producing Escherichia coli strains and its interaction with the enzymes. Chemotherapy 1998; 44: , TZOUVELEKIS LS, GAZOULI M, MARKOGIANNAKIS A, PARASKAKI E, LEGAKIS NJ, TZELEPI E. Emergence of third-generation cephalosporin-resistant Salmonella typhimurium in Greece: report of the first three cases. Journal of Antimicrobial Chemotherapy 1998; 42: ,068

11 39.GAZOULI M, TZELEPI E, MARKOGIANNAKIS A, LEGAKIS NJ, TZOUVELEKIS LS. Two novel plasmid-mediated cefotaxime-hydrolyzing -lactamases (CTX-M-5 and CTX-M-6) from Salmonella typhimurium. FEMS Microbiology Letters 1998; 165: , GAZOULI M, TZOUVELEKIS LS, VATOPOULOS AC, TZELEPI E. Transferable class C - lactamases in Escherichia coli strains isolated in Greek hospitals and characterization of two enzyme variants (LAT-3 and LAT-4) closely related to Citrobacter freundii AmpC -lactamase. Journal of Antimicrobial Chemotherapy 1998; 42: , GAZOULI M, LEGAKIS NJ, TZOUVELEKIS LS. Effect of substitution of Asn for Arg-276 in the cefotaxime-hydrolyzing class A -lactamase CTX-M-4. FEMS Microbiology Letters 1998; 169: µ 25 2, DEMETZOS C, STAHL B, ANASTASSAKI T, GAZOULI M, TZOUVELEKIS LS, RALLIS M. Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds. Planta Medica 1998; 65: , GIAKKOUPI P, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Aspartic acid for asparagine substitution at position 276 decreases susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 -lactamases. Journal of Antimicrobial Chemotherapy 1999; 43: µ 13 5, KYRIAKIS KP, TZELEPI E, FLEMETAKIS A, AVGERINOU H, TZOUVELEKIS LS, FRANGOULI E. Epidemiological aspects of male gonococcal infection in Greece. Sexually Transmitted Diseases 1999; 26: , TZELEPI E, KOUPPARI G, MAVROIDI A, ZAPHIROPOULOU A, TZOUVELEKIS LS. Erythromycin-resistant group A -haemolytic streptococci isolated in a paediatric hospital in Athens, Greece. Journal of Antimicrobial Chemotherapy 1999; 43: , TZOUVELEKIS LS, VATOPOULOS AC, KATSANIS G, TZELEPI E. A rare case of failure by an automated system to detect extended-spectrum -lactamase in a cephalosporin-resistant Klebsiella pneumoniae isolate. Journal of Clinical Microbiology 1999; 37:2388. µ 29 4, TZOUVELEKIS LS, BONOMO RA. SHV-type -lactamases. Current Pharmaceutical Design 1999; 5:

12 43 3, TASSIOS PT, GAZOULI M, TZELEPI E, MILCH H, KOZLOVA N, SIDORENKO SV, LEGAKIS NJ, TZOUVELEKIS LS. Spread of a Salmonella typhimurium clone resistant to third generation cephalosporins in three European countries. Journal of Clinical Microbiology 1999; 37: , GIAKKOUPI P, TZELEPI E, TASSIOS PT, LEGAKIS NJ, TZOUVELEKIS LS. Detrimental effect of the combination of R164S with G238S in TEM-1 -lactamase on the extended-spectrum activity conferred by each single mutation. Journal of Antimicrobial Chemotherapy 2000; 45: µ 9 5, TZOUVELEKIS LS, TZELEPI E, TASSIOS PT, LEGAKIS NJ. CTX-M-type - lactamases: an emerging group of extended-spectrum enzymes. International Journal of Antimicrobial Agents 2000; 13: , LOUKOVA V, TZOUVELEKIS LS, TASSIOS PT, THIEL W. (2000). Extended- spectrum - lactamases in Salmonella strains isolated in Austria. International Journal of Antimicrobial Agents. 2000; 15: , TASSIOS PT, CHATZICHRISTODOULOU C, LAMBIRI M, KANSOUZIDOU A, SARANDOPOULOU A, KREAMASTINOU J, TZOUVELEKIS LS, LEGAKIS NJ. Molecular typing of multi-drug resistant Salmonella blockley outbreak isolates from Greece. Emerging Infectious Diseases. 2000; 6: µ 18 6, GIAKKOUPI P, TZOUVELEKIS LS, TSAKRIS A, LOUKOVA V, SOFIANOU D, TZELEPI E. Characterization of IBC-1, a novel integron-associated extended- spectrum -lactamase from Enterobacter cloacae. Antimicrobial Agents and Chemotherapy 2000; 44: , MAVROIDI A, TZOUVELEKIS LS, TASSIOS PT, FLEMETAKIS A, DANIILIDOU M, TZELEPI E. Characterization of Neisseria gonorrhoeae strains with decreased susceptibility to fluoroquinolones isolated in Greece from 1996 to Journal of Clinical Microbiology 2000; 38: µ 16 4, MAVROIDI A, TSAKRIS A, TZELEPI E, TZOUVELEKIS LS. VIM-2 metallo- - lactamaseproducing Pseudomonas aeruginosa from Greece. Journal of Antimicrobial Chemotherapy 2000; 46:

13 5, TZELEPI E, ARVANITIDOU, TZOUVELEKIS LS, MAVROIDI A, TSAKRIS A. The isoelectric focusing patterns of -lactamases of Yersinia enterocolitica from aquatic environments. Journal of Antimicrobial Chemotherapy 2000; 46: , GIAKKOUPI P, HUJER AM, TZELEPI E, MIRIAGOU V, BONOMO RA, TZOUVELEKIS LS. Substitution of Thr for Ala-237 in TEM-17, TEM-12 and TEM- 24: alterations in -lactam resistance conferred on Escherichia coli. FEMS Microbiology Letters 2001; 201: µ 7 2, PETINAKI E, MIRIAGOU V, TZOUVELEKIS LS, POURNARAS S, HATZI F, KONTOS F, MANIATI M, MANIATIS AN. Methicillin-resistant Staphylococcus aureus in the hospitals of central Greece. International Journal of Antimicrobial Agents 2001; 18: , MAVROIDI A, TZOUVELEKIS LS, KYRIAKIS KP, AVGERINOU H, DANIILIDOU M, TZELEPI E. Chromosomal mutations in multiple antibiotic resistant Neisseria gonorrhoeae. Antimicrobial Agents and Chemotherapy 2001; 45: , MAVROIDI A, TZELEPI E, TSAKRIS A, MIRIAGOU V, SOFIANOU D, TZOUVELEKIS LS. An integron-associated -lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extendedspectrum -lactamase IBC-1. Journal of Antimicrobial Chemotherapy 2001; 48: , AQEL A, MANIATIS AN, LEGAKIS NJ, TZOUVELEKIS LS. Mupirocin-resistant Staphylococcus aureus in Greek hospitals. International Journal of Antimicrobial Agents 2001; 18: , LEBESSI E, DELAGRAMMATICAS H, TASSIOS PT, TZOUVELEKIS LS, IOANNIDOU S, FOUSTOUKOU M, LEGAKIS NJ. Extended-spectrum -lactamase- producing Klebsiella pneumoniae in a neonatal intensive care unit in the high- prevalence area of Athens, Greece. Journal of Clinical Microbiology 2002; 40: µ 26 4, MAVROIDI A, TZELEPI E, MIRIAGOU V, GIANNELI D, LEGAKIS NJ, TZOUVELEKIS LS. CTX- M-3-producing Escherichia coli from Greece. Microbial Drug Resistance 2002; 8: , PETINAKI E, MIRIAGOU V, TZOUVELEKIS LS, HATZI F, LEGAKIS NJ, MANIATIS AN. Evaluation of an anti-pbp 2a slide latex agglutination test in coagulase- negative staphylococci isolated in Greek hospitals. Diagnostic Microbiology and Infectious Diseases 2002; 42:

14 µ 4 2, VILLA L, MAMMINA C, MIRIAGOU V, TZOUVELEKIS LS, TASSIOS PT, NASTASI A, CARATTOLI A. Multi-drug, broad-spectrum cephalosporin resistance among Salmonella enterica serotype Enteritidis clinical isolates in Southern Italy. Journal of Clinical Microbiology 2002; 40: , KYRIAKIS KP, TZELEPI E, AVGERINOU H, TZOUVELEKIS LS, FLEMETAKIS A, FRANGOULI E. Current characteristics of male gonorrhoea outpatients in Athens, Greece. Sexually Transmitted Infections 2002; 78:E5. - 2, MIRIAGOU V, FILIP R, COMAN G, TZOUVELEKIS LS. Expanded-spectrum cephal sporinresistant Salmonella strains in Romania. Journal of Clinical Microbiology 2002; 40: µ 24 4, POURNARAS S, TSAKRIS A, MANIATI M, TZOUVELEKIS LS, MANIATIS AN. Identification of a novel metallo- -lactamase gene (blavim-4) in Pseudomonas aeruginosa. Antimicrobial Agents and C erapy 2002; 46: , MIRIAGOU V, TZELEPI E, GIANNELI D, TZOUVELEKIS LS. Escherichia coli with a self-transferable, multi-resistant plasmid coding for the metallo- -lactamase VIM-1. Antimicrobial Agents and Chemotherapy 2003; 47: , LEBESSI E, STAMOS G, FOUSTOUKOU M, VOURLI S, LEGAKIS NJ, TZOUVELEKIS LS. Performance of ESBL detection methods in clinical enterobacteria producing IBC-1. Journal of Clinical Microbiology 2003; 41:912. µ 1 4, GIAKKOUPI P, PETRIKKOS G, TZOUVELEKIS LS, TSONAS S, THE WHO-NET STUDY GROUP, LEGAKIS NJ, VATOPOULOS AC. Spread of integron-associated blavim genes among Pseudomonas aeruginosa strains in Greek hospitals. Journal of Clinical Microbiology 2003; 41: µ 41 4, TZOUVELEKIS LS, LUKOVA V, TASSIOS PT, FLUIT J, LEGAKIS NJ. - Lactamase-mediated resistance among Salmonella isolates from European hospitals. Clinical Microbiology and Infection 2003; 9: ,540

15 73.TZELEPI E, MAGANA H, PLATSOUKA E, SOFIANOU D, LEGAKIS NJ, TZOUVELEKIS LS. Extended-spectrum -lactamase types in Klebsiella pneumoniae and Escherichia coli in two Greek hospitals. International Journal of Antimicrobial Agents 2003; 21: , MIRIAGOU V, TZOUVELEKIS LS, ROSSITER S, TZELEPI E, ANGULO FJ, WHICHARD J. Imipenem resistance ia a Salmonella strain due to plasmid-mediated class A carbapenemase KPC-2. Antimicrobial Agents and Chemotherapy 2003; 47: , VOURLI S, KARTALI G, KONTOPOULOU C, SOFIANOU D, TZOUVELEKIS LS, TZELEPI E. Characterization of Klebsiella pneumoniae clinical strains producing a rare extended-spectrum - lactamase of the IBC type. International Journal of Antimicrobial Agents 2003; 21: , POURNARAS S, MANIATI M, PETINAKI E, TZOUVELEKIS LS, TSAKRIS A, LEGAKIS NJ, MANIATIS AN. Hospital outbreak of multiple clones of Pseudomonas aeruginosa carrying the unrelated beta-lactamase variants blavim-2 and blavim-4. Journal of Antimicrobial Chemotherapy 2003; 51: µ VOURLI S, TZOUVELEKIS LS, TZELEPI E, LEBESSI E, LEGAKIS NJ, MIRIAGOU V. Characterization of In111, a novel class 1 integron that carries the extended-spectrum -lactamase gene blaibc-1. FEMS Microbiology Letters 2003; 255: , GIAKKOUPI P, XANTHAKI A, KANELOPOULOU M, VLAHAKI A, MIRIAGOU V, KONTOU S, PAPAFRAGGAS E, MALAMOU H, TZOUVELEKIS LS, LEGAKIS NJ, VATOPOULOS AC. VIM-1 metallo- -lactamase-producing Klebsiella pneumoniae strains in Greek hospitals. Journal of Clinical Microbiology 2003; 41: µ 100 4, CHANIOTAKI S, GIAKKOUPI P, TZOUVELEKIS LS, PANAGIOTAKOS D, KOZANITOU M, PETRIKKOS G, AVLAMI A, THE WHONET STUDY GROUP, VATOPOULOS AC. Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece. Clinical Microbiology and Infection 2004; 10: , VOURLI S, GIAKKOUPI P, MIRIAGOU V, TZELEPI E, VATOPOULOS AC, TZOUVELEKIS LS. Novel GES/IBC extended-spectrum -lactamase variants with carbapenemase activity in clinical enterobacteria. FEMS Microbiology Letters 2004; 234: ,044

16 81.MIRIAGOU V, TASSIOS PT, LEGAKIS NJ, TZOUVELEKIS LS. (2004). Expanded- spectrum cephalosporin resistance in non-typhoid Salmonella. International Journal of Antimicrobial Agents 2004; 23: , MIRIAGOU V, TZOUVELEKIS LS, VILLA L, LEBESSI E, VATOPOULOS AC, CARATTOLI A, TZELEPI E. CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid. Antimicrobial Agents and Chemotherapy 2004; 48: , GANGOUE-PIEBOJI J, MIRIAGOU V, VOURLI S, TZELEPI E, NGASSAM P, TZOUVELEKIS LS. Emergence of CTX-M-15-producing enterobacteria in Cameroon and characterization of a blactx-m-15 element. Antimicrobial Agents and Chemotherapy 2005; 49: , GIAKKOUPI P, TZOUVELEKIS LS, DAIKOS GL, MIRIAGOU V, PETRIKKOS G, LEGAKIS NJ, VATOPOULOS AC. Discrepancies and interpretation problems in susceptibility testing of VIMproducing Klebsiella pneumoniae. Journal of Clinical Microbiology 2005; 43: , MIRIAGOU V, TZELEPI E, DAIKOS GL, TASSIOS PT, TZOUVELEKIS LS. Panresistance in metallo- -lactamase-producing Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy 2005; 55: , POLITI L, TASSIOS PT, LAMPIRI M, KANSOUZIDOU A, PASIOTOU A, MELOU K, VATOPOULOS AC, LEGAKIS NJ, TZOUVELEKIS LS. Repeated occurrence of ESBLs among minor serotypes of Salmonella enteritidis. Journal of Clinical Microbiology 2005; 43: , CHATZIPANAGIOTOU S, IOANNIDOU V, IOANNIDIS A, NICOLAOU C, PAPAVASILEIOU E, CHANIOTAKI S, VATOPOULOS A, TZOUVELEKIS L, LEGAKIS NJ. Absence of the plasmidmediated quinolone resistance qnra gene among Campylobacter jejuni clinical isolates from Greece. International Journal of Antimicrobial Agents 2005; 26: , MIRIAGOU V, CARATTOLI A, TZELEPI E, VILLA L, TZOUVELEKIS LS. IS26- associated In4- type integrons forming multiresistant loci in enterobacterial plasmids. Antimicrobial Agents and Chemotherapy 2005; 49: , POURNARAS S, IKONOMIDIS A, TZOUVELEKIS LS, TOKATLIDOU D, SPANAKIS N, MANIATIS AN, LEGAKIS NJ, TSAKRIS A. VIM-12, a novel metallo- -lactamase that ressembles a VIM-1/2 hybrid. Antimicrobial Agents and Chemotherapy 2005; 49:

17 21 4, HELMS M, LIGHFOOT D, POWLING J, BERGHOLD C, KORNSHOBER C, WYDO I, COLLARD JM, GODARD C, PRAZERES D, REIS EM, FONSECA L, FLINT J, POLLARI F, AHMED R, DEMCZUK W, HOSPEDALES J, CLARKE D, NURSE- LUCAS M, KARPISKOVA R, GERNER- SMIDT P, GILL N, O BRIEN S, THRELFALL J, SIITONEN A, LUKINMAA S, RABSCH W, TASSIOS PT, TZOUVELEKIS LS et al. International Salmonella typhimurium DT104 infections, Emerging Infectious Diseases 2005; 11: µ 96 6, GIAKKOUPI P, TAMBIC-ANDRASEVIC A, VOURLI S, SKRLIN J, SESTAN-CRNEK S, TZOUVELEKIS LS, VATOPOULOS AC. Transferable DHA-1 cephalosporinase in Escherichia coli. International Journal of Antimicrobial Agents 2005; 27: , PARASKAKIS I, KAFETZIS D, CHRISAKIS A, PAPAVASILLIOU H, KIRIKOU H, PANGALIS A, TZOUVELEKIS LS, ATHANASIOU T, LEGAKIS NJ, ON BEHALF OF THE NATIONAL SURVEILLANCE NETWORK FOR PNEUMOCOCCAL RESISTANCE. Serotypes and antibiotic resistance of Streptococcus pneumoniae recovered from children in Greece during Clinical Microbiology and Infection 2006; 12: µ 10 4, VOURLI S, TSORLINI H, KATSIFA H, POLEMIS M, TZOUVELEKIS LS, KONTODIMOU A, VATOPOULOS AC. Emergence of Proteus mirabilis carrying blavim-1 metallo- -lactamase gene. Clinical Microbiology and Infection 2006; 12: , TSAKRIS A, POURNARAS S, IKONOMIDIS A, TZOUVELEKIS LS, SOFIANOU D, LEGAKIS NJ, MANIATIS AN. VIM-1 carbapenemase in Acinetobacter baumannii. Emerging Infectious Diseases 2006; 12: , LOLI A, TZOUVELEKIS LS, TZELEPI E, CARATTOLI A, VATOPOULOS AC, TASSIOS PT, MIRIAGOU V. Sources of diversity of carbapenem resistance levels in Klebsiella pneumoniae carrying blavim-1. Journal of Antimicrobial Chemotherapy 2006; 58: , DAIKOS GL, PANAGIOTAKOPOULOU A, TZELEPI E, LOLI A, TZOUVELEKIS LS, MIRIAGOU V. Efficacy of imipenem against VIM-1-producing Klebsiella pneumoniae in a murine thigh infection model. Clinical Microbiology and Infection 2007; 13: , PANAGIOTAKOPOULOU A, DAIKOS GL, MIRIAGOU V, LOLI A, TZELEPI E, ZOUVELEKIS LS. Comparative in vitro killing of carbapenems and aztreonam against Klebsiella pneumoniae

18 producing VIM-1 metallo- -lactamase. International Journal of Antimicrobial Agents 2007; 29: , PAPAGIANNITSIS C, LOLI A, TZOUVELEKIS LS, TZELEPI E, MIRIAGOU V. SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. Antimicrobial Agents and Chemotherapy 2007; 51: , MIRIAGOU V, TZOUVELEKIS LS, FLEVARI K, TSAKIRI M, DOUZINAS EE Providencia stuartii with VIM-1 beta-lactamase. Journal of Antimicrobial Chemotherapy 2007; 60: , PAPAGIANNITSIS C, TZOUVELEKIS LS, TZELEPI E, MIRIAGOU V. Plasmid- encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrobial Agents and Chemotherapy 2007;51: , MAVROIDI A, PARASKAKIS I, PANGALIS A, KIRIKOU E, CHARISIADOU A, TASSIOS PT, TZOUVELEKIS LS. Spread of the Streptococcus pneumoniae Taiwan19F-14 clone among children in Greece. Clinical Microbiology and Infection 2007; 13: , PSICHOGIOU M, TASSIOS PT, AVLAMIS A, STEFANOU I, KOSMIDIS C, PLATSOUKA E, PANIARA O, XANTHAKI A, TOUTOUZA M, DAIKOS GL, TZOUVELEKIS LS. Ongoing epidemic of blavim-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey. Journal of Antimicrobial Chemotherapy 2007; 61: , LOLI A, TZOUVELEKIS LS, GIANNELI D, TZELEPI E, MIRIAGOU V. Outbreak of Acinetobacter baumannii with chromosomally encoded VIM-1 undetectable by imipenem-edta synergy tests. Antimicrobial Agents and Chemotherapy 2008; 52: , GIAKKOUPI P, VOURLI S, POLEMIS M, KALAPOTHAKI V, TZOUVELEKIS LS, VATOPOULOS AC. Supplementation of growth media with Zn2+ facilitates detection of VIM-2-producing Pseudomonas aeruginosa Journal of Clinical Microbiology 2008; 46: µ 6 4, ZIOGA A, WHICHARD JM, JOYCE K, TZELEPI E, TZOUVELEKIS LS, MIRIAGOU V. Evidence for chromosomal and plasmid location of CMY-2 cephalosporinase gene in Salmonella serotype Typhimurium. Journal of Antimicrobial Chemotherapy 2008; 61;

19 5, ZAPPAS S, GIAKKOUPI P, VOURLI S, HADJICHRISTODOULOU C, POLEMIS M, TZOUVELEKIS LS, AVLAMI A, VATOPOULOS A, DAIKOS GL, PETRIKKOS G. Epidemiology of metalloenzymeproducing Pseudomonas aeruginosa in a tertiary hospital in Greece. Journal of Chemotherapy. 2008; 20: , MIRIAGOU V, DOUZINAS EE, PAPAGIANNITSIS CC, PIPERAKI E, LEGAKIS NJ, TZOUVELEKIS LS. Emergence of Serratia liquefaciens and Klebsiella oxytoca with metallo-beta-lactamase-encoding IncW plasmids: further spread of the blavim-1-carrying integron In-e541. International Journal of Antimicrobial Agents. 2008; 32: , VASILAKOPOULOU A, PSICHOGIOU M, TZOUVELEKIS LS, TASSIOS PT, KOSMIDIS C, PETRIKKOS G, ROMA ES, CHARVALOS E, PASSIOTOU M, AVLAMI A, DAIKOS GL. Prevalence and characterization of class 1 integrons in Escherichia coli of poultry and human origin. Foodborne Pathogens & Disease. 2009; 6: E. coli 9 2, PAPAGIANNITSIS CC, TZOUVELEKIS LS, MIRIAGOU V. Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. Antimicrobial Agents and Chemotherapy. 2009;53(1): , ZIOGA A, WHICHARD JM, KOTSAKIS SD, TZOUVELEKIS LS, TZELEPI E, MIRIAGOU V. CMY- 31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. Antimicrobial Agents and Chemotherapy. 2009; 53: , DAIKOS GL, PETRIKKOS P, PSICHOGIOU M, KOSMIDIS C, VRYONIS E, SKOUTELIS A, GEORGOUSI K, TZOUVELEKIS LS, TASSIOS PT, BAMIA C, PETRIKKOS G. Prospective observational study of the impact of VIM-1 metallo- -lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections. Antimicrobial Agents and Chemotherapy. 2009; 53: , KOTSAKIS SD, PAPAGIANNITSIS CC, TZELEPI E, TZOUVELEKIS LS, MIRIAGOU V. Extendedspectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. Antimicrobial Agents and Chemotherapy. 2009; 53: , GIAKKOUPI P, PAPPA O, POLEMIS M, VATOPOULOS AC, MIRIAGOU V, ZIOGA A, PAPAGIANNITSIS CC, TZOUVELEKIS LS. Emerging Klebsiella pneumoniae isolates coproducing KPC- 2 and VIM-1 carbapenemases. Antimicrobial Agents and Chemotherapy. 2009; 53:

20 4, MIRIAGOU V, PAPAGIANNITSIS CC, TZELEPI E, CASALS JB, LEGAKIS NJ, TZOUVELEKIS LS. Detecting VIM-1 production in Proteus mirabilis by an imipenem-dipicolinic acid double disk synergy test. Journal of Clinical Microbiology. 2010; 48: , PAPAPARASKEVAS J, TZOUVELEKIS LS, TSAKRIS A, PITTARAS TE, LEGAKIS NJ; HELLENIC TIGECYCLINE STUDY GROUP. In vitro activity of tigecycline against 2423 clinical isolates and comparison of the available interpretation breakpoints. Diagnostic Microbiology and Infectious Diseases 2010; 66: , PAPAGIANNITSIS CC, GIAKKOUPI P, VATOPOULOS AC, TRYFINOPOULOU K, MIRIAGOU V, TZOUVELEKIS LS. Emergence of Klebsiella pneumoniae of a novel sequence type (ST383) producing VIM-4, KPC-2 and CMY-4 -lactamases. International Journal of Antimicrobial Agents. 2010; 36: , KOTSAKIS SD, MIRIAGOU V, TZELEPI E, TZOUVELEKIS LS. Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES - lactamases. Antimicrobial Agents and Chemotherapy. 2010; 54: , MIRIAGOU V, PAPAGIANNITSIS CC, KOTSAKIS SD, LOLI A, TZELEPI E, LEGAKIS NJ, TZOUVELEKIS LS. Sequence of pnl194, a 79.3-kilobase IncN plasmid carrying the blavim-1 metallo- lactamase gene in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 2010; 54: , ZIOGA A, MIRIAGOU V, TZELEPI E, DOUZINAS E, TSAKIRI M, LEGAKIS NJ, DAIKOS GL, TZOUVELEKIS LS. The ongoing challenge of acquired carbapenemases: a hospital outbreak of Klebsiella pneumoniae simultaneously producing VIM-1 and KPC-2. International Journal of Antimicrobial Agents. 2010; 36: , DAIKOS GL, VRYONIS E, PSICHOGIOU M, TZOUVELEKIS LS, LIATIS S, PETRIKKOS P, KOSMIDIS C, TASSIOS PT, BAMIAS G, SKOUTELIS A. Risk factors for bloodstream infection with Klebsiella pneumoniae producing VIM-1 metallo-beta-lactamase. Journal of Antimicrobial Chemotherapy. 2010; 65: , KOTSAKIS SD, PAPAGIANNITSIS CC, TZELEPI E, LEGAKIS NJ, MIRIAGOU V, TZOUVELEKIS LS. GES-13, a -lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2010; 54: ,841

21 122. PAPAGIANNITSIS CC, TZOUVELEKIS LS, KOTSAKIS SD, TZELEPI E, MIRIAGOU V. Sequence of pr3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 -lactamases. Antimicrobial Agents and Chemotherapy. 2011; 55: , KOTSAKIS SD, TZOUVELEKIS LS, PETINAKI E, TZELEPI E, MIRIAGOU V. Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: implications on hydrolysis of expanded-spectrum cephalosporins. Proteins 2011; 79: , PAPAGIANNITSIS CC, KOTSAKIS SD, PETINAKI E, VATOPOULOS AC, TZELEPI E, MIRIAGOU V, TZOUVELEKIS LS. Characterization of metallo- -lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147. Antimicrobial Agents and Chemotherapy 2011; 55: , PAPAGIANNITSIS CC, GIAKKOUPI P, VATOPOULOS AC, TRYFINOPOULOU K, MIRIAGOU V, TZOUVELEKIS LS. Emergence of Klebsiella pneumoniae of a novel sequence type (ST383) producing VIM-4, KPC-2 and CMY-4 -lactamases. International Journal of Antimicrobial Agents 2010; 36: , GIAKKOUPI P, PAPAGIANNITSIS CC, MIRIAGOU V, PAPPA O, POLEMIS M, TRYFINOPOULOU K,, TZOUVELEKIS LS, VATOPOULOS AC. An update of the evolving epidemic of blakpc-2-carrying Klebsiella pneumoniae in Greece ( ). Journal of Antimicrobial Chemotherapy 2011; 66: , PAPAGIANNITSIS CC, TZOUVELEKIS LS, KOTSAKIS SD, TZELEPI E, MIRIAGOU V. Sequence of pr3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 beta-lactamases. Antimicrobial Agents and Chemotherapy 2011; 55(1): , PAPAGIANNITSIS CC, KOTSAKIS SD, PETINAKI E, VATOPOULOS AC, TZELEPI E, MIRIAGOU V, TZOUVELEKIS LS. Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147. Antimicrobial Agents and Chemotherapy 2011; 55(7): , MAVROIDI, A., MIRIAGOU, V., MALLI, E., STEFOS, A., DALEKOS, G.N., TZOUVELEKIS, LS, PETINAKI, E. Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 -lactamase. International Journal of Antimicrobial Agents 2012; 39 (3): , AKOVA M, DAIKOS GL, TZOUVELEKIS LS, CARMELI Y. Interventional strategies and current

22 clinical experience with carbapenemase-producing Gram-negative bacteria. Clinical Microbiology & Infection 2012; 18(5): , KOTSAKIS SD, TZOUVELEKIS LS, ZERVA L, LIAKOPOULOS A, PETINAKI E. Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to -lactams. European Journal of Clinical Microbiology & Infectious Diseases 2012; 31(2): , LIAKOPOULOS A, MIRIAGOU V, KATSIFAS EA, KARAGOUNI AD, DAIKOS GL, TZOUVELEKIS LS, PETINAKI E. Identification of OXA-23-producing Acinetobacter baumannii Greece, 2010 to Euro Surveillance 2012; 17(11) , PAPAGIANNITSIS CC, TRYFINOPOULOU K, GIAKKOUPI P, PAPPA O, POLEMIS M, TZELEPI E, TZOUVELEKIS LS; CARBAPENEMASE STUDY GROUP, VATOPOULOS AC. Diversity of acquired - lactamases amongst Klebsiella pneumoniae in Greek hospitals. International Journal of Antimicrobial Agents 2012; 39(2): , PAPAGIANNITSIS CC, MIRIAGOU V, KOTSAKIS SD, TZELEPI E, VATOPOULOS AC, PETINAKI E, TZOUVELEKIS LS. Characterization of a transmissible plasmid encoding VEB-1 and VIM-1 in Proteus mirabilis. Antimicrobial Agents and Chemotherapy 2012; 56(7): , KARAGEORGOPOULOS DE, MIRIAGOU V, TZOUVELEKIS LS, SPYRIDOPOULOU K, DAIKOS GL. Emergence of resistance to fosfomycin used as adjunct therapy in KPC Klebsiella pneumoniae bacteraemia: report of three cases. Journal of Antimicrobial Chemotherapy 2012; 67(11): , TZOUVELEKIS LS, MARKOGIANNAKIS A, PSICHOGIOU M, TASSIOS PT, DAIKOS GL.Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clinical Microbiology Reviews 2012;25(4): , HÄCHLER H, KOTSAKIS SD, TZOUVELEKIS LS, GESER N, LEHNER A, MIRIAGOU V, STEPHAN R. Characterisation of CTX-M-117, a Pro174Gln variant of CTX-M-15 extended-spectrum -lactamase, from a bovine Escherichia coli isolate. International Journal of Antimicrobial Agents 2013; 41(1): , KOTSAKIS SD, CASELLI E, TZOUVELEKIS LS, PETINAKI E, PRATI F, MIRIAGOU V. Interactions of Oximino-Substituted Boronic Acids and -Lactams with the CMY-2-Derived Extended-Spectrum Cephalosporinases CMY-30 and CMY-42. Antimicrob Agents and Chemotherapy 2013; 57(2):

23 - 4, DAIKOS GL, MARKOGIANNAKIS A, SOULI M, TZOUVELEKIS LS. Bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae: a clinical perspective. Expert Reviews in Anti- Infective Therapy. 2012;10(12): ,283

24 ISI 1. VATOPOULOS A, TZOUVELEKIS L, TZELEPI E, LEGAKIS N. Cross resistance to norfloxacin and other antimicrobial agents among clinical isolates of gram-negative bacteria. International Journal of Experimental and Clinical Chemotherapy 1990; 3: TZOUVELEKIS L, VATOPOULOS A, MAKRIS A, MENTIS A, LEGAKIS N. The effect of magnesium limitation on outer surface components and serum sensitivity of Pseudomonas aeruginosa. Microbios Letters 1990; 45: µ µ 3. TZELEPI E, MENTIS A, SPILIADIS C, TZOUVELEKIS L. Antibiotic susceptibility and plasmid content of Helicobacter pylori strains isolated in Greece. International Journal of Experimental and Clinical Chemotherapy 1991; 4: TSAKRIS A, TZOUVELEKIS LS, VATOPOULOS AC, KAVOURINOS T, LEGAKIS NJ. "Antibiotic resistance among gram-negative bacilli isolated in Greek hospitals. Epidemiological, biochemical and genetic data". Antibiotika Monitor 1992; 8: MENTIS A, BALATSOS V, KASTANAS K, TZOUVELEKIS LS. In vitro susceptibility of Helicobacter pylori to metronidazole. Hellenic Journal of Gastroenterology 1993; 5: KANAVOURAS A, GAZOULI M, TZOUVELEKIS LS, PETRAKIS C. Evaluation of black table olives in different brines. Grasas y Aceites 2005; 56:

25 1. KNUIMAN J, HAUTVAST J, ZWIAUER K, WIDHALM K, DESMET M, DE BACKER G, RAHNEVA R, PETROVA V, DALH M, VIIKARI J, SEMMER N, KLUTHE R, DOBOS G, THIEL D, LAASER N, TRICHOPOULOU A, TZOUVELEKIS L, ET AL. Blood pressure and excretion of sodium, potassium, calcium and magnesium in 8- year and 9-year old boys from 19 European centers. European Journal of Clinical Nutrition1988; (supplement) 42:S847-S , DIMOPOULOU H, TZELEPI E, TZOUVELEKIS LS, PLATSOUKA E, KONSTANTOULAKI S, MENTIS AF, PANIARA O. Study of the resistance of Acinetobacter calcoacaticus clinical isolates to -lactam antibiotics. Journal of Chemotherapy 1993; 5 (supplement 1):S279-S281. µ - 1, SIATRA E, VALIRAKI A, KAKOULIDOU A, TZOUVELEKIS LS, MENTIS AF. Lipophilicity studies and evaluation of antibacterial properties of novel quarternary ammonium compounds. Chemical and Pharmaceutical Bulletin 1993; 42(S1):s392-s , PANIARA, PLATSOUKA E, DIMOPOULOU H, TZELEPI E, MIRIAGOU V, TZOUVELEKIS LS. Diversity of beta-lactam resistance levels among related Klebsiella pneumoniae strains isolated in an intensive care unit. Journal of Chemotherapy 2000; 12 (supplement 2):s204-s ,084 -