The American Journal of Pathology Official Journal of the American Society for Investigative Pathology May 2011 Volume 178, Number 5 On the Cover: Mast cell-derived oncostatin M (OSM) stimulates the growth of microvascular endothelial cells, osteoblasts, and fibroblasts, suggesting a pathogenetic role in systemic mastocytosis. Shown is expression of OSM in the HMC-1 mast cell line. KIT D816V HMC-1 cells were spun onto cytospin slides, and expression of OSM was detected by immunocytochemistry using an anti-osm antibody (red-brown). (See page 2344.) 1931 This Month in AJP Mini-Reviews 1932 The Pathoetiology of Neurofibromatosis 1 Eeva-Mari Jouhilahti, Sirkku Peltonen, Anthony M. Heape, and Juha Peltonen 1940 Importance of Molecular Features of Non Small Cell Lung Cancer for Choice of Treatment Cesar Moran Commentary 1949 Mitochondrial Biogenesis Drives Tumor Cell Proliferation Ubaldo E. Martinez-Outschoorn, Stephanos Pavlides, Federica Sotgia, and Michael P. Lisanti Related article appears on page 2066 Regular Articles Biomarkers, Genomics, Proteomics, and Gene Regulation 1953 Aberrant Expression of Retinoic Acid Signaling Molecules Influences Patient Survival in Astrocytic Gliomas Benito Campos, Franz-Simon Centner, Justo Lorenzo Bermejo, Ramadan Ali, Katharina Dorsch, Feng Wan, Jörg Felsberg, Rezvan Ahmadi, Niels Grabe, Guido Reifenberger, Andreas Unterberg, Jürgen Burhenne, and Christel Herold-Mende 1965 Hypermethylation of a Cluster of Krüppel-Type Zinc Finger Protein Genes on Chromosome 19q13 in Oropharyngeal Squamous Cell Carcinoma Roberto A. Lleras, Leslie R. Adrien, Richard V. Smith, Benjamin Brown, Naheed Jivraj, Christopher Keller, Cathy Sarta, Nicolas F. Schlecht, Thomas M. Harris, Geoffrey Childs, Michael B. Prystowsky, and Thomas J. Belbin 1975 Osteopontin Modulates Inflammation, Mucin Production, and Gene Expression Signatures After Inhalation of Asbestos in a Murine Model of Fibrosis Tara Sabo-Attwood, Maria E. Ramos-Nino, Maria Eugenia-Ariza, Maximilian B. MacPherson, Kelly J. Butnor, Pamela C. Vacek, Sean P. McGee, Jessica C. Clark, Chad Steele, and Brooke T. Mossman 1986 Tissue Microarray Cytometry Reveals Positive Impact of Homeodomain Interacting Protein Kinase 2 in Colon Cancer Survival Irrespective of p53 Function Isabelle Soubeyran, Isabelle Mahouche, Aude Grigoletto, Thierry Leste-Lasserre, Guillaume Drutel, Christophe Rey, Stephane Pedeboscq, France Blanchard, Veronique Brouste, Jean-Christophe Sabourin, Yves Bécouarn, Josy Reiffers, François Ichas, and Francesca De Giorgi Cardiovascular, Pulmonary, and Renal Pathology 1999 A Murine Model of Phosphate Nephropathy Philipp Eller, Kathrin Eller, Alexander H. Kirsch, Josef J. Patsch, Anna M. Wolf, Andrea Tagwerker, Ursula Stanzl, Reinhard Kaindl, Volker Kahlenberg, Gert Mayer, Josef R. Patsch, and Alexander R. Rosenkranz
2007 Diminished Met Signaling in Podocytes Contributes to the Development of Podocytopenia in Transplant Glomerulopathy Putri A. Agustian, Mario Schiffer, Wilfried Gwinner, Irini Schäfer, Katharina Theophile, Friedrich Modde, Clemens L. Bockmeyer, Jana Traeder, Ulrich Lehmann, Anika Gro hennig, Hans H. Kreipe, Verena Bröcker, and Jan U. Becker 2020 Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage: A Therapeutic Target of PPAR Chunhua Zhu, Songming Huang, Yanggang Yuan, Guixia Ding, Ronghua Chen, Bicheng Liu, Tianxin Yang, and Aihua Zhang Cell Injury, Repair, Aging, and Apoptosis 2032 N-Acetylcysteine Amide (NACA) Prevents Retinal Degeneration by Up-Regulating Reduced Glutathione Production and Reversing Lipid Peroxidation Andrew M. Schimel, Linu Abraham, Douglas Cox, Abdoulaye Sene, Courtney Kraus, Dru S. Dace, Nuran Ercal, and Rajendra S. Apte 2044 Ubiquitin C-Terminal Hydrolase-L1 Activity Induces Polyubiquitin Accumulation in Podocytes and Increases Proteinuria in Rat Membranous Nephropathy Catherine Meyer-Schwesinger, Tobias N. Meyer, Henning Sievert, Elion Hoxha, Marlies Sachs, Eva-Maria Klupp, Silvia Münster, Stefan Balabanov, Lucie Carrier, Udo Helmchen, Friedrich Thaiss, and Rolf A.K. Stahl Epithelial and Mesenchymal Cell Biology 2058 Dry Eye Symptoms Are Increased in Mice Deficient in Phospholipid Transfer Protein (PLTP) Niko L. Setälä, Jari Metso, Matti Jauhiainen, Antti Sajantila, and Juha M. Holopainen 2066 Aberrant Cell Proliferation by Enhanced Mitochondrial Biogenesis via mttfa in Arsenical Skin Cancers Chih-Hung Lee, Shi-Bei Wu, Chien-Hui Hong, Wei-Ting Liao, Ching-Ying Wu, Gwo-Shing Chen, Yau-Huei Wei, and Hsin-Su Yu Related Commentary appears on page 1949 2077 The Early Growth Response Gene Egr2 (Alias Krox20) Is a Novel Transcriptional Target of Transforming Growth Factor- that Is Up-Regulated in Systemic Sclerosis and Mediates Profibrotic Responses Feng Fang, Kohtaro Ooka, Swati Bhattachyya, Jun Wei, Minghua Wu, Pan Du, Simon Lin, Francesco Del Galdo, Carol A. Feghali-Bostwick, and John Varga 2091 Type 2 Helper T-Cell Cytokines Induce Morphologic and Molecular Characteristics of Atopic Dermatitis in Human Skin Equivalent Marijke Kamsteeg, Mieke Bergers, Roelie de Boer, Patrick L.J.M. Zeeuwen, Stanleyson V. Hato, Joost Schalkwijk, and Geuranne S. Tjabringa Gastrointestinal, Hepatobiliary, and Pancreatic Pathology 2100 Thymosin- 4 (T 4) Blunts PDGF-Dependent Phosphorylation and Binding of AKT to Actin in Hepatic Stellate Cells Karina Reyes-Gordillo, Ruchi Shah, Anastas Popratiloff, Sidney Fu, Anna Hindle, Frederick Brody, and Marcos Rojkind 2109 Bortezomib Stabilizes Mitotic Cyclins and Prevents Cell Cycle Progression via Inhibition of UBE2C in Colorectal Carcinoma Prashant Bavi, Shahab Uddin, Maqbool Ahmed, Zeenath Jehan, Rong Bu, Jehad Abubaker, Mehar Sultana, Nasser Al-Sanea, Alaa Abduljabbar, Luai H. Ashari, Samar Alhomoud, Fouad Al-Dayel, Sarita Prabhakaran, Azhar R. Hussain, and Khawla S. Al-Kuraya Immunopathology and Infectious Diseases 2121 Recently Infiltrating MAC387 Monocytes/Macrophages: A Third Macrophage Population Involved in SIV and HIV Encephalitic Lesion Formation Caroline Soulas, Cecily Conerly, Woong-Ki Kim, Tricia H. Burdo, Xavier Alvarez, Andrew A. Lackner, and Kenneth C. Williams 2136 A 2A Adenosine Receptor (A 2A AR) as a Therapeutic Target in Diabetic Retinopathy Ahmed S. Ibrahim, Mamdouh M. El-shishtawy, Wenbo Zhang, Ruth B. Caldwell, and Gregory I. Liou
2146 The Neuropathology of Fatal Cerebral Malaria in Malawian Children Katerina Dorovini-Zis, Kristopher Schmidt, Hanh Huynh, Wenjiang Fu, Richard O. Whitten, Dan Milner, Steve Kamiza, Malcolm Molyneux, and Terrie E. Taylor 2159 SPLUNC1 Promotes Lung Innate Defense Against Mycoplasma pneumoniae Infection in Mice Fabienne Gally, Y. Peter Di, Sean K. Smith, Maisha N. Minor, Yang Liu, Donna L. Bratton, S. Courtney Frasch, Nicole M. Michels, Stephanie R. Case, and Hong Wei Chu 2168 Dermatan Sulfate Interacts with Dead Cells and Regulates CD5 B-Cell Fate: Implications for a Key Role in Autoimmunity Julia Y. Wang, Jongmin Lee, Ming Yan, Jung-hyun Rho, and Michael H.A. Roehrl 2177 Human Proteins with Affinity for Dermatan Sulfate Have the Propensity to Become Autoantigens Jung-hyun Rho, Wei Zhang, Mandakolathur Murali, Michael H.A. Roehrl, and Julia Y. Wang 2191 Overexpression of Dominant Negative Peroxisome Proliferator-Activated Receptor- (PPAR ) in Alveolar Type II Epithelial Cells Causes Inflammation and T-Cell Suppression in the Lung Lingyan Wu, Guixue Wang, Peng Qu, Cong Yan, and Hong Du Metabolic, Endocrine, and Genitourinary Pathobiology 2205 Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism Andrew Advani, Qingling Huang, Kerri Thai, Suzanne L. Advani, Kathryn E. White, Darren J. Kelly, Darren A. Yuen, Kim A. Connelly, Philip A. Marsden, and Richard E. Gilbert 2215 Impaired Biomechanical Properties of Diabetic Skin: Implications in Pathogenesis of Diabetic Wound Complications Dustin M. Bermudez, Benjamin J. Herdrich, Junwang Xu, Robert Lind, David P. Beason, Marc E. Mitchell, Louis J. Soslowsky, and Kenneth W. Liechty Molecular Pathogenesis of Genetic and Inherited Diseases 2224 Increased Expression of Wild-Type or a Centronuclear Myopathy Mutant of Dynamin 2 in Skeletal Muscle of Adult Mice Leads to Structural Defects and Muscle Weakness Belinda S. Cowling, Anne Toussaint, Leonela Amoasii, Pascale Koebel, Arnaud Ferry, Laurianne Davignon, Ichizo Nishino, Jean-Louis Mandel, and Jocelyn Laporte 2236 Transcriptional Repression of Caveolin-1 (CAV1) Gene Expression by GATA-6 in Bladder Smooth Muscle Hypertrophy in Mice and Human Beings Ettickan Boopathi, Cristiano Mendes Gomes, Robert Goldfarb, Mary John, Vittala Gopal Srinivasan, Jaber Alanzi, S. Bruce Malkowicz, Hasmeena Kathuria, Stephen A. Zderic, Alan J. Wein, and Samuel Chacko 2252 Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function Robert Gruber, Peter M. Elias, Debra Crumrine, Tzu-Kai Lin, Johanna M. Brandner, Jean-Pierre Hachem, Richard B. Presland, Philip Fleckman, Andreas R. Janecke, Aileen Sandilands, W.H. Irwin McLean, Peter O. Fritsch, Michael Mildner, Erwin Tschachler, and Matthias Schmuth Neurobiology 2264 Induction of Ischemic Tolerance Protects the Retina from Diabetic Retinopathy Diego C. Fernandez, Pablo H. Sande, Mónica S. Chianelli, Hernán J. Aldana Marcos, and Ruth E. Rosenstein 2275 Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer s Disease Juan F. Reyes, Yifan Fu, Laurel Vana, Nicholas M. Kanaan, and Lester I. Binder 2286 Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer s Disease Anna Lord, Ola Philipson, Therése Klingstedt, Gunilla Westermark, Per Hammarström, K. Peter R. Nilsson, and Lars N.G. Nilsson
Stem Cells, Tissue Engineering, and Hematopoetic Elements 2299 Adipose Tissue-Derived Stem Cell in Vitro Differentiation in a Three-Dimensional Dental Bud Structure Federico Ferro, Renza Spelat, Giuseppe Falini, Annarita Gallelli, Federica D Aurizio, Elisa Puppato, Maura Pandolfi, Antonio Paolo Beltrami, Daniela Cesselli, Carlo Alberto Beltrami, Francesco Saverio Ambesi-Impiombato, and Francesco Curcio 2311 Lack of TNF- Induced MMP-9 Production and Abnormal E-Cadherin Redistribution Associated with Compromised Fusion in MCP-1 Null Macrophages Eleni A. Skokos, Antonios Charokopos, Khadija Khan, Jackie Wanjala, and Themis R. Kyriakides 2322 Adipose Injury Associated Factors Mitigate Hypoxia in Ischemic Tissues through Activation of Adipose-Derived Stem/Progenitor/Stromal Cells and Induction of Angiogenesis Hitomi Eto, Hirotaka Suga, Keita Inoue, Noriyuki Aoi, Harunosuke Kato, Jun Araki, Kentaro Doi, Takuya Higashino, and Kotaro Yoshimura 2333 Protein Phosphatase 2A Catalytic Subunit (PP2Ac ) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway Weiqian Chen, Pengyu Gu, Xuan Jiang, Hai-Bin Ruan, Chaojun Li, and Xiang Gao Tumorigenesis and Neoplastic Progression 2344 Identification of Oncostatin M as a STAT5-Dependent Mediator of Bone Marrow Remodeling in KIT D816V-Positive Systemic Mastocytosis Gregor Hoermann, Sabine Cerny-Reiterer, Andrea Perné, Miriam Klauser, Konrad Hoetzenecker, Katharina Klein, Leonhard Müllauer, Marion Gröger, Sebastian M.B. Nijman, Walter Klepetko, Peter Valent, and Matthias Mayerhofer 2357 Selection of Brain Metastasis-Initiating Breast Cancer Cells Determined by Growth on Hard Agar Lixia Guo, Dominic Fan, Fahao Zhang, Janet E. Price, Ju-Seog Lee, Dario Marchetti, Isaiah J. Fidler, and Robert R. Langley 2367 Skp2 Overexpression Is Associated with Loss of BRCA2 Protein in Human Prostate Cancer Arnaldo A. Arbini, Margherita Greco, Jorge L. Yao, Patricia Bourne, Ersilia Marra, Jer-Tsong Hsieh, Paul A. di Sant Agnese, and Loredana Moro 2377 CCN3 Impairs Osteoblast and Stimulates Osteoclast Differentiation to Favor Breast Cancer Metastasis to Bone Véronique Ouellet, Kerstin Tiedemann, Anna Mourskaia, Jenna E. Fong, Danh Tran-Thanh, Eitan Amir, Mark Clemons, Bernard Perbal, Svetlana V. Komarova, and Peter M. Siegel 2389 S100A4 Expression in Xenograft Tumors of Human Carcinoma Cell Lines Is Induced by the Tumor Microenvironment Hilde Ljones Wetting, Elin Hadler-Olsen, Synnøve Magnussen, Oddveig Rikardsen, Sonja E. Steigen, Elisabeth Sundkvist, Thrina Loennechen, Premasany Kanapathippillai, Hanne Kildalsen, Jan-Olof Winberg, Lars Uhlin-Hansen, and Gunbjørg Svineng 2397 Pirin Inhibits Cellular Senescence in Melanocytic Cells Silvia Licciulli, Chiara Luise, Gaia Scafetta, Maria Capra, Giuseppina Giardina, Paolo Nuciforo, Silvano Bosari, Giuseppe Viale, Giovanni Mazzarol, Chiara Tonelli, Luisa Lanfrancone, and Myriam Alcalay 2407 Overexpression of a Chromatin Remodeling Factor, RSF-1/HBXAP, Correlates with Aggressive Oral Squamous Cell Carcinoma Fu-Min Fang, Chien-Feng Li, Hsuan-Ying Huang, Ming-Tsong Lai, Chih-Mei Chen, I-Wen Chiu, Tian-Li Wang, Fuu-Jen Tsai, Ie-Ming Shih, and Jim Jinn-Chyuan Sheu Vascular Biology, Atherosclerosis, and Endothelium Biology 2416 Interleukin-1 Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration Sophie Lavalette, William Raoul, Marianne Houssier, Serge Camelo, Olivier Levy, Bertrand Calippe, Laurent Jonet, Francine Behar-Cohen, Sylvain Chemtob, Xavier Guillonneau, Christophe Combadière, and Florian Sennlaub 2424 Ultrastructural Analysis Reveals camp-dependent Enhancement of Microvascular Endothelial Barrier Functions via Rac1-Mediated Reorganization of Intercellular Junctions Volker Spindler, Dominik Peter, Gregory S. Harms, Esther Asan, and Jens Waschke
2437 Physiological Contribution of CD44 as a Ligand for E-Selectin during Inflammatory T-Cell Recruitment Maria Nácher, Ana Belén Blázquez, Bojing Shao, Adela Matesanz, Colette Prophete, M. Cecilia Berin, Paul S. Frenette, and Andrés Hidalgo Correspondence 2447 Statin Therapy May Not Apply to All Forms of Crescentic Glomerulonephritis Bahjat Al-Ani, Hamad Al Nuaimi, Caroline Savage, Mark A. Little, Akira Shimizu, Emiko Fujita, Shinya Nagasaka ASIP 2011 AJP CME Program in Pathogenesis appears online. See http://www.asip.org/cme/ journalcme.htm for examination and registration details. See below for CME accreditation statement. denotes participating articles in this issue CME Accrediation statement: This activity ( ASIP 2011 AJP CME Program in Pathogenesis ) has been planned and implemented in accordance with the Essential Areas and policies of the Accrediation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Federation of American Societies for Experimental Biology (FASEB) and the American Society for Investigative Pathology (ASIP). FASEB is accredited by the ACCME to provide continuing medical education for physicians. FASEB designates this educational activity ( ASIP 2011 AJP CME Program in Pathogenesis ) for a maximum of 50 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity.