Using Cost Effectiveness Analysis to Determine Inventory Size for a National Umbilical Cord Blood Bank

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Using Cost Effectiveness Analysis to Determine Inventory Size for a National Umbilical Cord Blood Bank"

Transcription

1 Using Cost Effectiveness Analysis to Determine Inventory Size for a National Umbilical Cord Blood Bank Martin Maiers, Bioinformatics National Marrow Donor Program, USA

2 NMDP Minneapolis, MN, USA NATIONAL MARROW DONOR PROGRAM 2 Creating Connections. Saving Lives.

3 Messages Cord Blood is an alternative to adult unrelated donors The more units are stored, the greater the likelihood that transplant candidates will match a unit Storing cord blood units is costly Benefits of increasing cord inventory must be weighed against the costs 3

4 Approach Estimate the likelihood that transplant candidates will match to a living unrelated marrow donor or a cord blood unit as a function of cord blood inventory Calculate the life years gained for each transplant type by match level using historical data Develop a model of the cord blood inventory level to estimate total costs as a function of the number of stored units 4

5 Motivation >22 U.S. public banks Charge a fee per transplanted unit ~ 15,000USD Complicated to search independently U.S. Congress commissioned a report from the Institute of Medicine to make recommendations on the governance and structure of a national cord blood bank This cost-effectiveness analysis was commissioned by the IOM to address the question: How many units should a national bank place in inventory? 5

6 Cord Blood Transplantation + Does not require healthy donors to undergo an invasive and discomforting procedure + HLA match requirements considered less stringent + Patients can undergo transplantation immediately instead of having to wait for the living unrelated donor search process to run its course - The volume of stem cells obtained from a single cord unit is limited - Patient weight must be considered - Used more often for pediatric patients 6

7 Cost/Benefit The larger the inventory, the greater the likelihood that transplant candidates will match to a stored unit Processing new cord blood units is costly The access benefits must be weighed against the storage costs 7

8 Assumptions Current inventory: effectively 50,000 Inventory sizes in the range 50, , , , ,000 TNC Dose 2.5 x

9 CBU TNC Histogram (N=36,135) TNC (x10^7) count

10 Model - HLA Matching 1. Use the expectation maximization (EM) algorithm to estimate the population frequency of HLA haplotypes types by racial/ethnic group 2. Calculate matching likelihood separately for donor & cord HLA-A & -B antigen level, DRB1 allele level 3. Sum over HLA types and racial groups to derive nationallyrepresentative estimates Donor match probabilities incorporate donor availability based on historical patterns Donor match probabilities based on 2,267,366 fully typed US donors Cord match incorporates a requirement of TNC dose of /kg Patient bodyweight is modeled using empirical weight distribution Kollman C, et al. Transplantation. 2004;78:

11 Results - Matching: Adult 6/6 Cord 6/6 Donor or 6/6 Cord 5/6+ Cord 6/6 Donor or 5/6+ Cord 4/6+ Cord 300, , , ,000 50,000 6/6 Donor or 4/6+ Cord Proportion of patients aged 20+ finding a match 11

12 Results - Matching: Pediatric 6/6 Cord 6/6 Donor or 6/6 Cord 5/6+ Cord 6/6 Donor or 5/6+ Cord 4/6+ Cord 300, , , ,000 50,000 6/6 Donor or 4/6+ Cord Proportion of patients aged <20 finding a match 12

13 Model - Life Years Number of CBU transplants Estimate: 8,200 unrelated transplant candidates Medical urgency (assume 25% are urgent) Urgent: consider cord blood transplants exclusively Non-urgent: adult donor preferred Matching more stringent for donors: donor transplants are considered only if the donor matches to the recipient at 7/8 or 8/8 alleles P(8/8 HRM 6/6 LRM) = 56% P(7/8 HRM 6/6 LRM) = 26% P(7/8 HRM 5/6 LRM) = 24% 13 Flomenberg N, et al. Blood. 2004;104:

14 Adult Patients 5,467 Adult Patients 4,100 Non-Urgent 1,367 Urgent 4,048 5/6+ donor match 52 no donor match cord match 6/6 94 5/ /6 608 no cord match 218 HR donor match / /8 no HR donor 1512 cord match 6/6 0 5/6 0 4/6 10 no cord match 42 cord match 6/6 52 5/ /6 780 no cord match

15 Pediatric Patients 2,733 Pediatric Patients 2,050 Non-Urgent 683 Urgent 1,350 6/6 donor match 700 no donor match cord match 6/ / /6 149 no cord match 14 HR donor match 756 8/8 no HR donor 594 cord match 6/6 7 5/ /6 327 no cord match 42 cord match 6/ / /6 52 no cord match 4 15

16 Projected Number: Annual Cord Transplants 300, , , ,000 50,000 Pediatric 4/6 Cord Blood 5/6 Cord Blood 6/6 Cord Blood , , , ,000 50,000 Adult 4/6 Cord Blood 5/6 Cord Blood 6/6 Cord Blood

17 Model - 5 year Survival /8 donor 7/8 donor 6/6 cord 5/6 cord 4/6 cord no transpl ant Adult Pediatric Pediatric Adult 17

18 Cost Model Cost Model Parameters Parameter Description Value Unit Inventory parameters N 0 Initial inventory 50,000 cord units λ Discard rate 0.50 proportion y Length of storage before discard 20 years Cost parameters c PS Cost of initial processing, stored unit $1,500 dollars c PD Cost of initial processing, discarded unit $500 dollars c S Cost of storage, annual $50 dollars c T Cost of transplantation $220,000 dollars E Endowment $9,000,000 dollars A Annual administrative cost $1,000,000 dollars r Discount rate 0.03 proportion 18

19 Cost Model C 0 = [(1 λ)c PS + λc PD ] N N 0 1 λ Cost of increasing cord blood inventory to a target size C = [(1 λ)c PS + λc PD ]U + c s N + A Annual costs for a cord blood bank TC( N ) = C + rc 0 + c T T ICER(N,N') = TC(N') TC(N) LY(N') LY(N) Total cost of transplants Incremental Cost- Effectiveness Ratio: cost per life-year-gained by increasing inventory from N to N 19

20 Cost per life year gained Cost Per Life Year Gained as a Function of Cord Inventory Cord Inventory 50, , , , ,000 Total costs (millions) Total $146 $162 $175 $187 $210 Incremental NA $16 $13 $12 $23 Life years gained Total 77,003 77,437 77,672 77,830 78,042 Incremental NA Incremental cost per life year NA $37,667 $55,873 $75,953 $106,948 20

21 21

22 Results The cost per life year gained associated with increasing inventory from 50,000 to 100,000 units is $38,000 - $75,000 from 100,000 to 150,000 units is $59,000 - $142,000 22

23 Conclusion Assuming the monetary value of a year of life exceeds $100,000: Expanding the cord blood inventory above current levels to 100, ,000 units is cost-effective 23

24 Future Analyses Selection of a graft source Cord as first choice Model international search Enhance matching model high-resolution haplotypes, refine race/ethnic categories Explore race/ethnic equity Effects of targeted recruitment Enhance survival model Include cell dose/matching interaction Multiple cord transplants 24

25 Acknowledgements Working Group David H. Howard, Ph.D. Emory University David Meltzer, M.D., Ph.D. University of Chicago Mary M. Horowitz, M.D. Center for International Blood and Marrow Transplant Research Brent Logan, Ph.D. Center for International Blood and Marrow Transplant Research Martin Maiers, B.S. National Marrow Donor Program Loren Gragert, B.S., B.A. National Marrow Donor Program Michelle Setterholm, B.S. National Marrow Donor Program Craig Kollman, Ph.D. Jaeb Center for Health Research Funding National Academy of Sciences, USA ONR N

Economics of Cord Blood Banking. Michael Boo NMDP Be The Match September 11, 2015

Economics of Cord Blood Banking. Michael Boo NMDP Be The Match September 11, 2015 Economics of Cord Blood Banking Michael Boo NMDP Be The Match September 11, 2015 Historical Use UCB Use Data 2 NMDP Historical Transplants by Product 7,000 6,500 6,000 5,500 5,000 4,500 4,000 3,500 3,000

More information

Most Patients who Need an Allo Transplant Can Find a Well Matched Donor

Most Patients who Need an Allo Transplant Can Find a Well Matched Donor Most Patients who Need an Allo Transplant Can Find a Well Matched Donor Important Points: Most patients can find a well matched or a very well matched available adult donor in the Be The Match Registry.

More information

Department of Economics, UCSB UC Santa Barbara

Department of Economics, UCSB UC Santa Barbara Department of Economics, UCSB UC Santa Barbara Peer Reviewed Title: Saving lives with stem cell transplants Author: Bergstrom, Ted, UC Santa Barbara Sheehan-Connor, Damien, Wesleyan University Garratt,

More information

Department of Economics, UCSB UC Santa Barbara

Department of Economics, UCSB UC Santa Barbara Department of Economics, UCSB UC Santa Barbara Peer Reviewed Title: Saving Lives with Stem Cell Transplants Author: Bergstrom, Ted, UC Santa Barbara Sheehan Conor, Damien Garratt, Rodney Publication Date:

More information

Title: SECTION 7.0 NZBMDR STANDARDS PROCESS FOR DONOR IDENTIFICATION

Title: SECTION 7.0 NZBMDR STANDARDS PROCESS FOR DONOR IDENTIFICATION NZBMDRGuidelines-007.10 Date Effective: 01/05/2010 Page 1 Title: SECTION 7.0 NZBMDR STANDARDS PROCESS FOR DONOR IDENTIFICATION Authorised by: Executive Officer Contributing Authors: ABMDR Scientific Expert

More information

The Cord Blood Industry and Be The Match

The Cord Blood Industry and Be The Match The Cord Blood Industry and Be The Match Arthur Busse Manager of Business Analytics NMDP: Be The Match Sept. 11, 2015 Be The Match Mission Saving Lives with cellular therapy through science, service and

More information

HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry

HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry The new england journal of medicine special article HLA Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry Loren Gragert, B.S., B.A., Mary Eapen, M.B., B.S., Eric Williams, Ph.D., John

More information

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape GENReports: Market & Tech Analysis Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape > Enal Razvi, Ph.D. Biotechnology Analyst, Managing Director SELECTBIO US enal@selectbio.us

More information

U.S. Department of Health and Human Services. Are Distributed to Cord Blood Banks Participating In the National Cord Blood Inventory.

U.S. Department of Health and Human Services. Are Distributed to Cord Blood Banks Participating In the National Cord Blood Inventory. U.S. Department of Health and Human Services Interim DRAFT: Report DO to NOT Congress CIRCULATE on How Federal Funds Are Distributed to Cord Blood Banks Participating In the National Cord Blood Inventory

More information

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION Chapter 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION 1.1 OVERVIEW OF THE CORD BLOOD TRANSPLANTATION STUDY Bone marrow transplantation

More information

No. 43/2007 The role of the state in establishing a public cord blood stem cell bank i

No. 43/2007 The role of the state in establishing a public cord blood stem cell bank i No. 43/2007 The role of the state in establishing a public cord blood stem cell bank i By Professor Vernon Louw MMed MBChB (Stell), Int.Med (Stell), Certified Clinical Haematologist (Leuven, Belgium) Associate

More information

Public Cord Blood Banking at the National Cord Blood Program (NCBP)

Public Cord Blood Banking at the National Cord Blood Program (NCBP) Public Cord Blood Banking at the National Cord Blood Program (NCBP) A. Scaradavou, MD Medical Director, National Cord Blood Program, New York Blood Center Associate Attending, Pediatric BMT Memorial Sloan-Kettering

More information

Q: Why is there a need for people to join the Be The Match Registry?

Q: Why is there a need for people to join the Be The Match Registry? Q: Why is there a need for people to join the Be The Match Registry? A: Thousands of patients with blood cancers like leukemia and lymphoma, sickle cell and other life-threatening diseases depend on the

More information

CBS National Public Cord Blood Bank. Did you donate your cord blood?

CBS National Public Cord Blood Bank. Did you donate your cord blood? CBS National Public Cord Blood Bank Did you donate your cord blood? Tanya Petraszko MD FRCPC October 2014 Overview What is a stem cell? The importance of HLA Need for cord blood stem cells For all Canadians

More information

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE HIND AL HUMAIDAN, MD,FRCPA Director, Blood Bank (Donor & Transfusion Services) and Stem Cell Cord Blood Bank Consultant Hematopathologist INTRODUCTION

More information

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement for the Utility of Autologous or Family Cord Blood Unit Storage (This policy statement has been approved and adopted by the WMDA board on the 25 th of May 2006) The Cord Blood Registries

More information

Cord Blood Market Trends, circa 2014

Cord Blood Market Trends, circa 2014 GENReports: Market & Tech Analysis Cord Blood Market Trends, circa 2014 > Enal Razvi, Ph.D. Managing Director Select Biosciences, Inc. enal@selectbio.us Topic Introduction and Scope The focus of this GEN

More information

How to select a donor and product for allogeneic HCT

How to select a donor and product for allogeneic HCT How to select a donor and product for allogeneic HCT Dr Bronwen Shaw 10 February 2015 Overview Who (and where) are the donors What factors determine how we choose between them Acquisition Clinical Donor

More information

Selecting an appropriately matched donor for hematopoietic

Selecting an appropriately matched donor for hematopoietic Transplant Outcomes in Acute Leukemia (I) Mary Eapen a and John E. Wagner b Umbilical cord blood (UCB) has gradually emerged over the last decade as an alternative source of hematopoietic cells for transplantation

More information

Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients

Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant Recipients Filippo Milano, 1 J. Lee Nelson, 1, 2 Colleen Delaney 1,3 1 Clinical Research Division, Fred Hutchinson Cancer Research

More information

Helping you find the one match.. Guide for Unrelated Stem Cell Transplant Patients OneMatch Stem Cell and Marrow Network BLOOD.

Helping you find the one match.. Guide for Unrelated Stem Cell Transplant Patients OneMatch Stem Cell and Marrow Network BLOOD. Helping you find the one match.. Guide for Unrelated Stem Cell Transplant Patients OneMatch Stem Cell and Marrow Network BLOOD.CA WWW This guide is intended for patients in need of an unrelated volunteer

More information

The donor search: the best donor or cord blood unit

The donor search: the best donor or cord blood unit The donor search: the best donor or cord blood unit Dr Bronwen Shaw Consultant in haematopoietic cell transplantation Royal Marsden Hospital /Anthony Nolan Overview Where do we find donors/units for transplantation

More information

Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose

Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose Pr Eliane Gluckman, MD, FRCP, Hospital Saint Louis, University Paris- Diderot, France Should Haplo-identical transplantation be preferred to cord blood in patients without a matched donor? Disclosure of

More information

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Pros and Cons of Stem Cell Sources and their availability in Africa Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Introduction The ability to perform a haematopoietic stem

More information

Cord Blood Bank Business Plan

Cord Blood Bank Business Plan Cord Blood Bank Business Plan A sample of how to create a new program Produced by the AABB subsection: Cellular Therapy Business Management with major contributions by Nicole Omer TABLE OF CONTENTS Page

More information

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood [Track 2: What Is a Transplant?] Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood can be an effective treatment for people with blood cancers such as leukemia,

More information

Selection of the Optimal Umbilical Cord Blood Unit

Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Selection of the Optimal Umbilical Cord Blood Unit Massachusetts General Hospital September, 2013 OUTLINE Cell Dose HLA Match Allele Level HLA C KIR Directional Mismatch NIMA HLA Antibodies

More information

Umbilical Cord Blood Transplantation

Umbilical Cord Blood Transplantation Umbilical Cord Blood Transplantation V Rocha MD, PhD Hopital Saint Louis, Paris University 7 CIBMTR Milwaukee Umbilical Cord blood transplantation Background History Clinical results in children and adults

More information

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement on the Utility of Autologous or Family Cord Blood Unit Storage The WMDA Board adopted this policy on 25 th of May 2006. Policy updated _April 2011 The Cord Blood Working Group and

More information

SEARCHING FOR A BONE MARROW DONOR

SEARCHING FOR A BONE MARROW DONOR SEARCHING FOR A BONE MARROW DONOR Angela received a bone marrow transplant from an unrelated donor to treat her non-hodgkin s lymphoma. INFORMATION FOR PATIENTS AND THEIR FAMILIES For patients who need

More information

Search Coordinator Certificate

Search Coordinator Certificate Educational. Expert led. E learning. Information and registration Educational. Expert led. E learning. Professionals involved in unrelated adult donor/cord blood unit search and selection are essential

More information

Quality Issues with Umbilical Cord Blood for Transplant

Quality Issues with Umbilical Cord Blood for Transplant Quality Issues with Umbilical Cord Blood for Transplant Amanda Murphy BS, David McKenna MD, and Jeffrey McCullough, MD Department of Laboratory Medicine & Pathology University of Minnesota Minneapolis,

More information

HRSA Update to the Advisory Council on Blood Stem Cell Transplantation. Shelley Grant September 15, 2014

HRSA Update to the Advisory Council on Blood Stem Cell Transplantation. Shelley Grant September 15, 2014 HRSA Update to the Advisory Council on Blood Stem Cell Transplantation Shelley Grant September 15, 2014 Presentation Overview Review legislative authority for Stem Cell Therapeutic and Research Reauthorization

More information

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease 1 Produced by St. Jude Children s Research Hospital Departments of Hematology, Patient

More information

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Bone Marrow Transplantation

More information

Preamble. 1. If it is necessary, are you willing to receive follow up questions to help clarify any answers to the survey questions?

Preamble. 1. If it is necessary, are you willing to receive follow up questions to help clarify any answers to the survey questions? Preamble The purpose of this inter organizational survey is to gather data regarding transplant center practices for preparing cord blood units for administration, including characterizing and confirming

More information

An!Update!to!the!Cord! Blood!Marketplace,! September!2014!

An!Update!to!the!Cord! Blood!Marketplace,! September!2014! GENReports: Market & Tech Analysis An!Update!to!the!Cord! Blood!Marketplace,! September!2014! > Enal Razvi, Ph.D. Managing Director Select Biosciences, Inc. enal@selectbio.us! The,focus,of,this,GEN,Market,&,Tech,Analysis,Report,is,to,provide,

More information

Blood-Forming Stem Cell Transplants

Blood-Forming Stem Cell Transplants Blood-Forming Stem Cell Transplants What are bone marrow and hematopoietic stem cells? Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic

More information

Jeffrey W. Chell, M.D.

Jeffrey W. Chell, M.D. Jeffrey W. Chell, M.D. Management Experience 2000 Present National Marrow Donor Program Minneapolis, MN Chief Executive Officer Facilitates over 6,000 Bone Marrow and Stem Cell transplants between volunteer

More information

THE INFLUENCE OF TISSUE (IN)COMPATIBILITY IN UMBILICAL CORD BLOOD TRANSPLANTATION

THE INFLUENCE OF TISSUE (IN)COMPATIBILITY IN UMBILICAL CORD BLOOD TRANSPLANTATION THE INFLUENCE OF TISSUE (IN)COMPATIBILITY IN UMBILICAL CORD BLOOD TRANSPLANTATION Matjaž Jeras Blood Transfusion Centre of Slovenia Tissue Typing Center Šlajmerjeva 6, 1000 Ljubljana, Slovenia matjaz.jeras@ztm.si

More information

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells

More information

The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings. Prof. Tony Pagliuca

The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings. Prof. Tony Pagliuca The future of unrelated Stem Cell Transplant in the UK: DOH Working Party Findings Prof. Tony Pagliuca UK STEM CELL STRATEGIC FORUM The future of unrelated donor SCT in the UK Antonio Pagliuca, Transplant

More information

Program Report to the Advisory Council on Blood Stem Cell Transplantation. Shelley Grant September 11, 2015

Program Report to the Advisory Council on Blood Stem Cell Transplantation. Shelley Grant September 11, 2015 Program Report to the Advisory Council on Blood Stem Cell Transplantation Shelley Grant September 11, 2015 Presentation Overview Review legislative authority for Stem Cell Therapeutic and Research Reauthorization

More information

Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be?

Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be? Original Article Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be? Sergio Querol 1,2,3 Ghulam J. Mufti, 3 Steven G.E. Marsh, 1,2 Antonio Pagliuca,

More information

Stem Cell Transplantation and the Canadian First Nations Community. Becky Luk (PTLS) Tanya Petraszko, MD

Stem Cell Transplantation and the Canadian First Nations Community. Becky Luk (PTLS) Tanya Petraszko, MD Stem Cell Transplantation and the Canadian First Nations Community Becky Luk (PTLS) Tanya Petraszko, MD Why is there a need for stem cells? Our Story Why are we engaging the First Nations, Metis and Inuit

More information

Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012

Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012 Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Massachusetts General Hospital June, 2012 OUTLINE Cell Dose HLA Typing HLA C and KIR HLA Antibodies ABO and Racial/Ethnic

More information

SAVE A LIFE... BY GIVING LIFE!

SAVE A LIFE... BY GIVING LIFE! SAVE A LIFE... BY GIVING LIFE! FOLLOW US ON: HÉMA-QUÉBEC PUBLIC CORD BLOOD BANK www.hema-quebec.qc.ca Scan this code with your smart phone to access the page Register to the Public Cord Blood Bank on the

More information

Design of the Hellenic Public Cord Blood Bank Network

Design of the Hellenic Public Cord Blood Bank Network Design of the Hellenic Public Cord Blood Bank Network Keramydas Christos, Vlachos Dimitrios, Iakovou Eleftherios Department of Mechanical Engineering Aristotle University of Thessaloniki chkeramy@auth.gr;

More information

The Danish Bone Marrow Donor Registry DBMDR

The Danish Bone Marrow Donor Registry DBMDR The DBMDR Vision To achieve and maintain a position as an internationally recognized hematopoietic stem cell donor registry with respect to high quality of donor data base and HLA typing, individualized,

More information

A fact sheet UNRELATED BONE MARROW AND CORD BLOOD STEM CELL TRANSPLANTS

A fact sheet UNRELATED BONE MARROW AND CORD BLOOD STEM CELL TRANSPLANTS A fact sheet UNRELATED BONE MARROW AND CORD BLOOD STEM CELL TRANSPLANTS Each year, thousands of patients are diagnosed with diseases treatable by a blood stem cell transplant. These blood stem cells can

More information

UMBILICAL CORD BLOOD COLLECTION

UMBILICAL CORD BLOOD COLLECTION UMBILICAL CORD BLOOD COLLECTION by Frances Verter, PhD Founder & Director, Parent's Guide to Cord Blood Foundation info@parentsguidecordblood.org and Kim Petrella, RN Department of Obstetrics and Gynecology

More information

General Information about Donating Blood Stem Cells

General Information about Donating Blood Stem Cells General Information about Donating Blood Stem Cells This document contains general information about joining the national Registry and donating blood stem cells. You could be the Questions & Answers Paul

More information

Be the One to Save a Life: Partnerships with Be The Match. Melinda Caltabiano

Be the One to Save a Life: Partnerships with Be The Match. Melinda Caltabiano Be the One to Save a Life: Partnerships with Be The Match Melinda Caltabiano Awesome Video https://www.youtube.com/watch?v=l0md h9p4ry0&list=uumudnzf2lklmlkuw_yxqe ha The NATIONAL MARROW DONOR PROGRAM

More information

STEM CELL THERAPEUTIC OUTCOMES DATABASE

STEM CELL THERAPEUTIC OUTCOMES DATABASE C W Bill Young Cell Transplantation Program STEM CELL THERAPEUTIC OUTCOMES DATABASE BUS06_1ppt Stem Cell Therapeutic and Research Act of 2005 (PL 109-129) 129) Authorizing law, preceded by efforts to:

More information

ANTHONY NOLAN SEARCH ALGORITHM FOR A BASIC CORD BLOOD UNIT SELECTION BY SERGIO QUEROL AND IRINA EVSEEVA FEBRUARY 2012

ANTHONY NOLAN SEARCH ALGORITHM FOR A BASIC CORD BLOOD UNIT SELECTION BY SERGIO QUEROL AND IRINA EVSEEVA FEBRUARY 2012 ANTHONY NOLAN SEARCH ALGORITHM FOR A BASIC CORD BLOOD UNIT SELECTION BY SERGIO QUEROL AND IRINA EVSEEVA FEBRUARY 2012 PAGE 1 OF 7 PRINCIPLES FOR A NEW ALGORITHM Once cord blood transplantation (CBT) is

More information

Donate your baby s cord blood and save lives.

Donate your baby s cord blood and save lives. Donate your baby s cord blood and save lives. A public nonprofit cord blood bank licensed by the FDA Each year, thousands of people are diagnosed with life-threatening diseases that may be cured with a

More information

Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents

Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents Eileen Quinlan Collection Supervisor, Brampton (GTA) 2015-11-10 History One Match Stem Cell and Marrow

More information

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Background Hematopoietic stem cell transplantation (HSCT) is

More information

GAO NATIONAL CORD BLOOD INVENTORY. Practices for Increasing Availability for Transplants and Related Challenges. Report to Congressional Committees

GAO NATIONAL CORD BLOOD INVENTORY. Practices for Increasing Availability for Transplants and Related Challenges. Report to Congressional Committees GAO United States Government Accountability Office Report to Congressional Committees October 2011 NATIONAL CORD BLOOD INVENTORY Practices for Increasing Availability for Transplants and Related Challenges

More information

Summary of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Status

Summary of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Status of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Shelley Grant Branch Chief, Blood Stem Cell Transplantation Program September 11, 2015 Overview December 20, 2005 - HRSA began

More information

Overview of OneMatch, including the OneMatch Public Cord Blood Bank

Overview of OneMatch, including the OneMatch Public Cord Blood Bank Overview of OneMatch, including the OneMatch Public Cord Blood Bank Dr. Heidi Elmoazzen, Director OneMatch Public Cord Bank 2012-09-27 Outline Overview and Introduction Overview of the need for stem cells

More information

Cord Blood Transplant. E. Gluckman Eurocord ESH-EBMT training course Vienna 2014

Cord Blood Transplant. E. Gluckman Eurocord ESH-EBMT training course Vienna 2014 Cord Blood Transplant E. Gluckman Eurocord ESH-EBMT training course Vienna 2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell

More information

RESOURCE. Medical Case Management Benchmarks. ING Re Industry Survey

RESOURCE. Medical Case Management Benchmarks. ING Re Industry Survey The following material was developed prior to RGA s acquisition on January 1, 2010 of the Group Reinsurance CLAIMS ADVISORY SERVICE IN THIS ISSUE: RESOURCE Reinsurance Outcomes and Service Experts VOLUME

More information

Human Leukocyte Antigens - HLA

Human Leukocyte Antigens - HLA Human Leukocyte Antigens - HLA Human Leukocyte Antigens (HLA) are cell surface proteins involved in immune function. HLA molecules present antigenic peptides to generate immune defense reactions. HLA-class

More information

OneMatch National. Sue Smith, Executive Director, Stem Cells 2011-11- 04

OneMatch National. Sue Smith, Executive Director, Stem Cells 2011-11- 04 OneMatch National Public Cord Blood Bank Blood Matters 2011 Sue Smith, Executive Director, Stem Cells 2011-11- 04 No Disclosures To Declare The presenter does not have any involvement with the industry

More information

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases ! 21%! EUROCORD 6756 cord blood transplantations performed from 1988 to March 2010 in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases * missing center

More information

CORD BLOOD TRANSPLANTATION STUDY EXPANDED ACCESS PROTOCOL APPENDIX A SAMPLE CONSENT FORM

CORD BLOOD TRANSPLANTATION STUDY EXPANDED ACCESS PROTOCOL APPENDIX A SAMPLE CONSENT FORM APPENDIX A SAMPLE CONSENT FORM CORD BLOOD TRANSPLANTATION (COBLT) STUDY SAMPLE CONSENT FORM FOR THE EXPANDED ACCESS PROTOCOL You (your child) are being asked to take part in a clinical research study.

More information

Cord Blood Stem Cell Transplantation

Cord Blood Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA FACTS Cord Blood Stem Cell Transplantation No. 2 in a series providing the latest information on blood cancers Highlights Umbilical cord blood, like bone marrow and peripheral

More information

International NetCord Foundation Executive Committee Conference Call Minutes May 23, 2007

International NetCord Foundation Executive Committee Conference Call Minutes May 23, 2007 International NetCord Foundation Executive Committee Conference Call Minutes Committee Members: Board Members: Staff: President Joan Garcia and Drs. Yves Beguin and Elizabeth Shpall Drs. Cristina Navarrete

More information

Product Complaint Form Instructions

Product Complaint Form Instructions Product Complaint Form Instructions Note: Product Complaint Definition: Failure/possible failure of a drug (includes biological products) to meet any of its specifications. This includes complaints that

More information

Cord Blood Advisory Group: Organization and Highlights (from November 2013 meeting)

Cord Blood Advisory Group: Organization and Highlights (from November 2013 meeting) Cord Blood Advisory Group: Organization and Highlights (from November 2013 meeting) Presented to the AABB Center for Cellular Therapies Cord Blood subsection by Merry Duffy Director, Cord Blood Operations,

More information

Natasha Kekre, 1 Jennifer Philippe, 2 Ranjeeta Mallick, 3 Susan Smith, 2 and David Allan 1,2,4. 1. Introduction

Natasha Kekre, 1 Jennifer Philippe, 2 Ranjeeta Mallick, 3 Susan Smith, 2 and David Allan 1,2,4. 1. Introduction Hindawi Publishing Corporation Stem Cells International Volume 2013, Article ID 124834, 6 pages http://dx.doi.org/10.1155/2013/124834 Research Article Modelling Improvements in Cell Yield of Banked Umbilical

More information

New Zealand Bone Marrow Donor Registry

New Zealand Bone Marrow Donor Registry Title: Authorised by: SECTION 9.0 NZBMDR STANDARDS PROCESS FOR AN UNRELATED STEM CELL DONOR WORKUP & IDENTIFICATION OF CORD BLOOD UNITS Executive Officer Contributing Authors: Sally Gordon Dr Hilary Blacklock

More information

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program ISCT 2012 Disclosures: none The problem:

More information

Center Activity (07/01/2009-06/30/2010) Center Region United States Tables for More Information

Center Activity (07/01/2009-06/30/2010) Center Region United States Tables for More Information Program Summary Center Activity (07/01/2009-06/30/2010) Center Region United States Tables for More Information Deceased donor transplants (n=number) 0 169 0 07C,08C,09C On waitlist at start (n) 0 0 0

More information

hematopoietic stem cells from cord blood: - costless but too expensive? Dr. Vincent Kindler Geneva Cord Blood Bank HUG vincent.kindler@hcuge.

hematopoietic stem cells from cord blood: - costless but too expensive? Dr. Vincent Kindler Geneva Cord Blood Bank HUG vincent.kindler@hcuge. hematopoietic stem cells from cord blood: - costless but too expensive? Dr. Vincent Kindler Geneva Cord Blood Bank HUG vincent.kindler@hcuge.ch Spring water: Manufactured by nature COSTLESS Cord Blood:

More information

In the Senate of the United States, AMENDMENT:

In the Senate of the United States, AMENDMENT: In the Senate of the United States, December, 01. Resolved, That the bill from the House of Representatives (H.R. 0) entitled An Act to reauthorize the Stem Cell Therapeutic and Research Act of 00, and

More information

Statement of Joanne Kurtzberg, M.D.

Statement of Joanne Kurtzberg, M.D. Statement of Joanne Kurtzberg, M.D. President of the Cord Blood Association Jerome Harris Distinguished Professor of Pediatrics and Pathology Chief Scientific Officer and Medical Director, Robertson Clinical

More information

The Impact of Maternal, Neonatal and Collections factors on the TNC count of an Umbilical Cord Blood Donation

The Impact of Maternal, Neonatal and Collections factors on the TNC count of an Umbilical Cord Blood Donation The Impact of Maternal, Neonatal and Collections factors on the TNC count of an Umbilical Cord Blood Donation By: NHS Cord Blood Bank (Colindale Laboratory) Date: 26 th September 2014 NHS insert Cord your

More information

Guidance for Industry and FDA Staff

Guidance for Industry and FDA Staff Guidance for Industry and FDA Staff Investigational New Drug Applications for Minimally Manipulated, Unrelated Allogeneic Placental/Umbilical Cord Blood Intended for Hematopoietic and Immunologic Reconstitution

More information

BCSLS Telehealth Stem Cell Transplantation. Becky Luk, Patient & Transplant Liaison Specialist

BCSLS Telehealth Stem Cell Transplantation. Becky Luk, Patient & Transplant Liaison Specialist BCSLS Telehealth Stem Cell Transplantation Becky Luk, Patient & Transplant Liaison Specialist Our Story Why is there a need for stem cells? What is OneMatch Stem Cell & Marrow Newtork s role in Stem Cell

More information

BCSLS Telehealth Stem Cell Transplantation. Our Story. Diseases treated with stem cell transplants. Why is there a need for stem cells?

BCSLS Telehealth Stem Cell Transplantation. Our Story. Diseases treated with stem cell transplants. Why is there a need for stem cells? BCSLS Telehealth Stem Cell Transplantation Becky Luk, Patient & Transplant Liaison Specialist Our Story Why is there a need for stem cells? What is OneMatch Stem Cell & Marrow Newtork s role in Stem Cell

More information

11/10/2011. History of CBUs. 10-CBA providing access to unlicensed cord blood units. The FDA s involvement. The FDA s involvement, cont.

11/10/2011. History of CBUs. 10-CBA providing access to unlicensed cord blood units. The FDA s involvement. The FDA s involvement, cont. History of CBUs First CBU transplant done in 1988 10-CBA providing access to unlicensed cord blood units Using the NMDP IND to access unlicensed cord blood units Amy Hays, Sr. Clinical Research Specialist,

More information

Public Cord Blood Tissue Bank Committee on Health Care Services and Representative Peaden

Public Cord Blood Tissue Bank Committee on Health Care Services and Representative Peaden HOUSE OF REPRESENTATIVES COMMITTEE ON HEALTH CARE SERVICES ANALYSIS BILL #: HB 2337 (PCB HCS 00-07) RELATING TO: SPONSOR(S): TIED BILL(S): Public Cord Blood Tissue Bank Committee on Health Care Services

More information

Annual Report 2006. The Norwegian Bone Marrow Donor Registry

Annual Report 2006. The Norwegian Bone Marrow Donor Registry Annual Report The Norwegian Bone Marrow Donor Registry ANNUAL REPORT THE NORWEGIAN BONE MARROW DONOR REGISTRY The Norwegian Bone Marrow Donor Registry (NBMDR) was established in 199 at the Institute of

More information

Fiscal Year 2013 Annual Progress Report on the C.W. Bill Young Cell Transplantation Program and National Cord Blood Inventory Program

Fiscal Year 2013 Annual Progress Report on the C.W. Bill Young Cell Transplantation Program and National Cord Blood Inventory Program U.S. Department of Health and Human Services Fiscal Year 2013 Annual Progress Report on the C.W. Bill Young Cell Transplantation Program and National Cord Blood Inventory Program Executive Summary The

More information

Department of Veterans Affairs VHA DIRECTIVE 2012-018 Veterans Health Administration Washington, DC 20420 July 9, 2012

Department of Veterans Affairs VHA DIRECTIVE 2012-018 Veterans Health Administration Washington, DC 20420 July 9, 2012 Department of Veterans Affairs VHA DIRECTIVE 2012-018 Veterans Health Administration Washington, DC 20420 SOLID ORGAN AND BONE MARROW TRANSPLANTATION 1. PURPOSE: This Veterans Health Administration (VHA)

More information

Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP)

Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) October 18, 2014 19th Congress of APBMT, Hangzhou, China AMIR ALI HAMIDIEH, MD Iranian

More information

S. 681 IN THE SENATE OF THE UNITED STATES

S. 681 IN THE SENATE OF THE UNITED STATES II TH CONGRESS 1ST SESSION S. 1 To amend the Public Health Service Act to establish a National Cord Blood Stem Cell Bank Network to prepare, store, and distribute human umbilical cord blood stem cells

More information

What is a Stem Cell Transplantation?

What is a Stem Cell Transplantation? What is a Stem Cell Transplantation? Guest Expert: Stuart, MD Associate Professor, Medical Oncology www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with Drs. Ed and Ken. I am

More information

ASSEMBLY, No. 2591 STATE OF NEW JERSEY. 212th LEGISLATURE INTRODUCED FEBRUARY 23, 2006

ASSEMBLY, No. 2591 STATE OF NEW JERSEY. 212th LEGISLATURE INTRODUCED FEBRUARY 23, 2006 ASSEMBLY, No. STATE OF NEW JERSEY th LEGISLATURE INTRODUCED FEBRUARY, 00 Sponsored by: Assemblywoman CHARLOTTE VANDERVALK District (Bergen) SYNOPSIS Requires hospitals to provide information to pregnant

More information

Umbilical Cord Blood Stem Cells Current Status & Future Potential

Umbilical Cord Blood Stem Cells Current Status & Future Potential Umbilical Cord Blood Stem Cells Current Status & Future Potential Natasha Ali Assistant Professor Haematology Department of Pathology & Laboratory Medicine/Oncology The Aga Khan University Email: natasha.ali@aku.edu

More information

DEPARTMENT OF HEALTH AND HUMAN SERVICES. Health Resources and Services Administration. Advisory Council on Blood Stem Cell Transplantation

DEPARTMENT OF HEALTH AND HUMAN SERVICES. Health Resources and Services Administration. Advisory Council on Blood Stem Cell Transplantation This document is scheduled to be published in the Federal Register on 01/21/2016 and available online at http://federalregister.gov/a/2016-01127, and on FDsys.gov Billing Code 4165-15 DEPARTMENT OF HEALTH

More information

OUR JOURNEY THROUGH THE YEARS

OUR JOURNEY THROUGH THE YEARS The King Faisal Specialist Hospital and Research Centre Experience in Hematology, Oncology and Bone Marrow Transplantation OUR JOURNEY THROUGH THE YEARS REGGIE BELKHEDIM A Brief Overview: King Faisal Specialist

More information

User Guide. A. Program Summary B. Waiting List Information C. Transplant Information

User Guide. A. Program Summary B. Waiting List Information C. Transplant Information User Guide This report contains a wide range of useful information about the pancreas transplant program at Saint Louis University Hospital (MOSL). The report has three main sections: A. Program Summary

More information

1st Session 114 242 STEM CELL THERAPEUTIC AND RESEARCH REAUTHORIZATION ACT OF 2015

1st Session 114 242 STEM CELL THERAPEUTIC AND RESEARCH REAUTHORIZATION ACT OF 2015 114TH CONGRESS REPORT " HOUSE OF REPRESENTATIVES! 1st Session 114 242 STEM CELL THERAPEUTIC AND RESEARCH REAUTHORIZATION ACT OF 2015 SEPTEMBER 8, 2015. Committed to the Committee of the Whole House on

More information

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program Cord Blood: that other stem cell source Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program CBMTG April 2012 The problem: In order to perform a BMT from one person to another one needs

More information

Cord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014

Cord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014 Cord Blood Transplant Past and Future E. Gluckman Eurocord ISCT Paris 24/04/2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information