Institutional Animal Care and Use Committee Policy Title: Chemical and Drug Hazards
|
|
- Brett Lyons
- 8 years ago
- Views:
Transcription
1 Institutional Animal Care and Use Committee Policy Title: Chemical and Drug Hazards PURPOSE To describe the procedures for all individuals involved in the dosing, handling, disposal and housing of animals dosed with hazardous drugs or chemicals at The University of Kansas Medical Center. SCOPE Drugs and chemicals that are toxic, known or suspected carcinogens, reproductive hazards, teratogens, mutagens and antineoplastic agents may be used in animal protocols. All chemicals being used must be documented in an Institutional Animal Care and Use Committee (IACUC) approved Animal Care and Use Protocol (ACUP). Failure to document all hazards may result in suspension of research privileges. As all chemicals and drugs do not pose the same risk to human health, each ACUP or Risk Assessment document shall be reviewed for the determination of risk level on a case-by-case basis. Therefore, increased containment and/or more stringent procedures may be required to be implemented that are not described within this SOP. The term may is used through-out this document and is not intended to be synonymous to the terms mandatory, shall, requirement or must, but rather as an alternative, added precaution or possibility for requirement. Finally, different animal species may be treated differently as each species may pose specific challenges. Due to the prevailing nature of this type of research involving rodents this SOP will concentrate on hazardous research involving mice and rats. RESPONSIBILTIES Principal Investigator (PI) A. Submit a thoroughly completed ACUP or Risk Assessment document that includes: a) A list of all hazardous drugs or chemicals b) All known human hazards at the dosage levels to be administered c) Effective PPE that reduce or eliminate exposure d) Additional measures to be taken in order to mitigate occupational exposure B. For Medium and High Containment Areas, post the Section H portion of the IACUC approved protocol and available Material Safety Data Sheets (MSDS) within the LAR designated area 72 hours prior to animal dosing. Additionally, the PI is to place Chemical Hazard cage cards on all cages at the time of dosing.
2 Low Containment Areas do NOT require Chemical Hazard Cage Cards or MSDS posting. Special Note: PI s are NOT to remove cage cards, only LAR staff are permitted to do so. C. Train research staff in good laboratory practices as well as hazards specific to the PI s research environment and ensure personnel donning N-95 masks have been trained and fit-tested. PI s must ensure that personnel donning PAPR s are properly trained. D. The PI is strongly encouraged to play an active role in determining the risk level by providing all vital information to assist the EHS department in providing an accurate assessment to prevent research hindering and/or occupational exposure. Environment, Health & Safety A. Utilize multiple entities, individuals and/or departments to determine the risk level regarding each hazard. Multiple factors will play a fundamental role (e.g. hazard half-life, toxicity level, dosage level, pharmacokinetics EPA regulated chemicals or other regulations). B. Inform IACUC administration, LAR management and the PI of proper safety measures to be implemented for Medium and High Risk Level agents. NOTE: Low Level Risk agents do not require notification. LAR Facility Management A. Communicate to LAR staff information related to hazardous chemicals and drugs from the IACUC. Additionally, notify IACUC regarding breaches of procedures or practices. B. Ensure that LAR staff complies with all safety measures implemented, including training on proper use of personal protective equipment and safety equipment. Ensure personnel donning N-95 masks have been trained and fit-tested. Management Staff must unsure that personnel donning PAPR s are properly trained. Comment [RCL1]: I think I would rephrase this as it reads to me like the PAPR s need to be trained rather than the employee. I would change it to have a period after fit tested and start a new sentence that says something along the lines of PI s must ensure that personnel donning PAPR s are properly trained. Comment [RCL2]: See comment above IACUC Committee A. Assist in upholding decisions made by the EHS office in regards to hazard level. STANDARD PRACTICES The below procedures represent general standard practices for animal housing, animal handling, hazard communication, final animal disposition, contaminated bedding/water/feed and any additional safety measures to be taken for each risk level regarding animals dosed with hazardous chemicals or drugs. Regarding any housing scenario, all PI s must consult with LAR management prior to ordering/creating animals for all logistics regarding specific housing rooms and cage locations within each room as well as equipment availability (e.g. biological safety cabinets BSC).
3 Low Risk Hazards A. Low risk animals will be considered and handled as no-risk due to the extremely low chemical hazard. NOTE: it must be understood that the no-risk status only applies if the chemical is being used appropriately and at the approved doing/prepared levels denoted within the IACUC protocol. B. Examples of Low Risk Hazards In general, the following hazards can be categorized as Low Risk. NOTE: it must be understood each project is taken on a case-by-case basis and particular factors may play role in re-categorization to a higher risk. a. Tomoxifen b. Ethanol c. Advertin d. BPA-bisphenol e. Taurine f. Omeprazole Medium Risk Hazards A. Animal Housing Animals will be housed in the Medium Risk Containment area designated for chemical and drug animal housing. Ventilated housing cage systems or disposable caging shall be implemented. The LAR will be responsible for cage changing. Animals may be placed back into general holding areas as determined on a case-by-case basis. Two criteria must be met in order to successfully return animals to any general holding area: 1. The desire to return animals to the general holding area after a period of time must be denoted in the approved IACUC Animal Protocol Section H thoroughly describing the reason and appropriate data for assurance of no personnel occupational exposure threat from a chemical for drug stand-point. 2. LAR approval must be granted prior to animal transfer. B. Animal Handing Increased PPE practices may be implemented (N-95 mask, PAPR unit, double nitrile gloves, disposable gowns, bouffant cap, shoe covers, safety eyewear). Outer gloves shall be changed when transitioning to animals dosed with a different agent or a different PI. Animal manipulations shall be performed in either a Cage Changing Station or BSC. C. Hazard Communication
4 The PI is required to post the Section H portion of the IACUC approved protocol within the LAR designated area 72 hours prior to animal dosing. Additionally, the PI is to place Chemical Hazard cage cards on all cages at the time of dosing. D. Final Animal Disposition Standard carcass disposal practices may be implemented. E. Contaminated Bedding, Water & Feed Contaminated bedding, unused water and feed will be considered contaminated 3 days post dosing and until after the first cage change unless specified otherwise. Contaminated bedding, unused water and feed shall be dumped by the LAR and collected as biohazard waste. NOTE: Autoclaving contaminated waste in not recommended unless there is an associated biohazard. F. Additional Safety Measures PPE shall be removed prior to exiting the animal room as biohazard waste. Hands shall be washed after glove removal. G. Examples of Medium Risk Hazards In general, the following hazards can be categorized as Medium Risk. NOTE: it must be understood each project is taken on a case-by-case basis and particular factors may play role in re-categorization to a lower or higher risk. a. Streptozotocin b. Tributyltin Chloride High Risk Hazards A. Animal Housing Animals will be housed in the High Risk Containment area designated for chemical and drug animal housing. Ventilated housing cage systems or disposable caging shall be implemented. The LAR will be responsible for cage changing. Animals may be placed back into general holding areas as determined on a case-by-case basis. Two criteria must be met in order to successfully return animals to any general holding area: 1. The desire to return animals to the general holding area after a period of time must be denoted in the approved IACUC Animal Protocol Section H thoroughly describing the reason and appropriate data for assurance of no personnel occupational exposure threat from a chemical for drug stand-point. 2. LAR approval must be granted prior to animal transfer. B. Animal Handing Increased PPE practices shall be required (N-95 mask, double nitrile gloves, disposable gowns, bouffant cap, shoe covers, safety eyewear). Additional PPE requirements may be implemented (carbon and/or HEPA filtered respirator system devices - PAPR). Outer gloves shall be changed when transitioning to animals dosed with a different agent or a different PI. Animal manipulations shall be performed in a Class II, Type B2 BSC. C. Hazard Communication
5 The PI is required to post the Section H portion of the IACUC approved protocol within the LAR designated area 72 hours prior to animal dosing. Additionally, the PI is to place Chemical Hazard cage cards on all cages at the time of dosing. D. Final Animal Disposition Standard carcass disposal practices can be implemented. If the hazard is EPA regulated, the PI shall contact the EHS department for animal carcass disposal. E. Contaminated Bedding, Water & Feed Contaminated bedding, unused water and feed shall be dumped by the LAR and collected as biohazard waste. All bedding will be considered contaminated for the life of the study while housed in the chemical hazard room. Unused feed and water treated with EPA regulated hazards may need to be collected by the LAR and be submitted for chemical waste pick-up through EHS. NOTE: Autoclaving contaminated waste in not recommended unless there is an associated biohazard. F. Additional Safety Measures PPE shall be removed prior to exiting the animal room as biohazard waste. Hands shall be washed after glove removal. G. Examples of High Risk Hazards In general, the following hazards can be categorized as High Risk. NOTE: it must be understood each project is taken on a case-by-case basis and particular factors may play role in re-categorization to a lower risk. a. Carbon tetrachloride b. Experimental drugs in which the PI cannot offer data to support it as being a lower risk. Biological/Chemical Combined Risk Hazards There may be projects that require the use of med-high risk chemical hazards and biological hazards that may be potentially harmful to research animals. These scenarios will require animals to be housed in a specific Bio/Chem Containment area. The practices that will be implemented will be the same as for High Risk Hazards. Before any animals are ordered the PI must contact LAR management in order to make arrangements for animal housing space. An example of a study that would be considered a Bio/Chem hazard would involve carbon tetrachloride and MPV (Mouse Parvo Virus). AT-RISK INDIVIDUALS There are some individuals that may be at higher risk of illness, injury or death due to either pre-existing health conditions or future health dispositions. Examples may include: pregnant women, women at child bearing age, women who plan to be pregnant and any immunocompromised individual. Personnel who fall into one of these categories may be at a higher risk of occupational exposures that may cause serious harm to health, fetuses, reproductive systems or in extreme circumstances, exposure may potentially be lethal. Hazards that have the potential to pose these risks will require special personnel considerations.
6 Considerations may include: the donning of additional PPE, restriction from working in such areas, job duty reassignment or additional safety measures. Any individual that feels they fall into an At-Risk status should immediately notify both their supervisor and the KU Occupational Health Clinic to ensure measures are taken to mitigate any occupation exposure. POTENTIAL EXPOSURES KUMC is dedicated to fostering a safe environment. As with any animal bite or scratch, individuals bitten or scratched by animals exposed to hazardous chemicals are expected to notify their supervisor immediately. The employees who have been potentially exposed to chemical hazardous agents will seek medical attention by visiting the Occupational Health Clinic in G110 Delp between 7am to 4:30pm Monday through Friday. If the potential exposure occurs after hours then the individual will go to the KU Hospital Emergency Room (followed by a visit to the Occupational Health Clinic on the next business day). Additionally, the Environment, Health & Safety Office must be notified of the incident. Comment [RCL3]: According to their website, their hours are 7 am to 4:30 pm. Approved/Renewed by IACUC:
Minimizing Occupational Exposure to Hazardous Chemicals in Animal Protocols
Environmental Health and Safety Minimizing Occupational Exposure to Hazardous Chemicals in Animal Protocols Chemicals that are highly toxic or corrosive, known or suspected carcinogens, reproductive hazards,
More informationStandard Operating Procedure for Dacarbazine in Animals
Standard Operating Procedure for Dacarbazine in Animals 1. Health hazards Dacarbazine, also known as DTIC, DIC, and Imidazole Carboxamide, is an antineoplastic chemotherapy drug used in the treatment of
More informationStandard Operating Procedure for the Use of Particularly Hazardous Drugs/Chemicals in Animals
1. Purpose Standard Operating Procedure for the Use of Particularly Hazardous Drugs/Chemicals in Animals PO Box 245101 Tucson, AZ 85724-5101 Voice: (520) 626-6850 FAX: (520) 626-2583 rlss.arizona.edu Exposure
More informationINSTITUTIONAL POLICY AND PROCEDURE (IPP) Department: Manual: Section:
HOSPITAL NAME INSTITUTIONAL POLICY AND PROCEDURE (IPP) Department: Manual: Section: TITLE/DESCRIPTION POLICY NUMBER HANDLING OF H AZARDOUS DRUGS EFFECTIVE DATE REVIEW DUE REPLACES NUMBER NO. OF PAGES APPROVED
More informationBill Mixon, RPh, MS Senior Associate Gates Healthcare Associates
Bill Mixon, RPh, MS Senior Associate Gates Healthcare Associates 14 pharmacists and 1 epidemiologist make up the committee USP staff FDA and CDC representatives have input but do not vote Call for Candidates
More informationKUMC. Medical Surveillance Program
KUMC Medical Surveillance Program INTRODUCTION Employees at KUMC could potentially be exposed to safety hazards such as chemical, biological, and physical hazards. These hazards are most likely to occur
More informationSafe Handling of Oral Chemotherapy and targeted Agents. ภญ.อภ รมย เหล าเจร ญเก ยรต ฝ ายเภส ชกรรม โรงพยาบาลศ ร ราช
Safe Handling of Oral Chemotherapy and targeted Agents. ภญ.อภ รมย เหล าเจร ญเก ยรต ฝ ายเภส ชกรรม โรงพยาบาลศ ร ราช Chemotherapy Agent. Low therapeutic index. -Increase risk for medication error. Hazardous
More informationOccupational Health and Safety in the Laboratory (Undergraduate Students)
Occupational Health and Safety in the Laboratory (Undergraduate Students) Introduction and scope of the Guidelines These guidelines have been written for all laboratory practical classes at the University
More informationTo provide direction for the safe handling, administration and disposal of hazardous drugs.
Subsection: MEDICATION Related terms: Cytotoxic Drugs, Antineoplastic Drugs Authorized by: Clinical Directors CS-04-02-01 Page 1 of 9 Date Established: October 2006 Date For Review: September 2014 Dates
More informationCHEMICAL SPILL MANAGEMENT GUIDELINES
WHS Unit CHEMICAL SPILL MANAGEMENT GUIDELINES Contents 1 Purpose... 2 2 Scope... 2 3 Definitions... 2 4 Roles and Responsibilities... 2 5 General... 2 6 Defining Major or Minor Spill... 3 7 Major Spill
More informationSTANDARD OPERATING PROCEDURES DIVISION OF COMPARATIVE MEDICINE UNIVERSITY OF SOUTH FLORIDA
STANDARD OPERATING PROCEDURES DIVISION OF COMPARATIVE MEDICINE UNIVERSITY OF SOUTH FLORIDA SOP#: 013.4 Date Issued: 11/00 Date Revised: 9/14 Page 1 of 7 TITLE: SCOPE: RESPONSIBILITY: PURPOSE: All New Animal
More informationChemotherapy Spill Response:
Chemotherapy Spill Response: Antineoplastic Spills Outside Of A Fume Hood Lisa Hudley, RN Training Coordinator Safety & Environmental Compliance William Guess Director Safety & Environmental Compliance
More informationSTANDARD OPERATING PROCEDURES SPILL RESPONSE AND CLEAN-UP OUTSIDE BIOSAFETY CABINET
BIOLOGICAL SPILL KIT IN A 5 GALLON BUCKET WITH LID Spill response and cleanup procedures (SOP) 1 Notepad 1 Pen 6 Business cards 1 Permanent marker 1 trash bag 6 Biohazard stickers 1 roll duct tape 1 roll
More informationCOLUMBUS STATE COMMUNITY COLLEGE EMPLOYEE SAFETY MANUAL
COLUMBUS STATE COMMUNITY COLLEGE EMPLOYEE SAFETY MANUAL HAZARDOUS MATERIAL MANAGEMENT Effective October 15, 1995 Page 1 of 4 Updated August, 2008 Revised August, 2009 A. Columbus State Community College
More informationOESO Ergonomics Division...919-668-ERGO(3746) Duke Police...919-684-2444 Corporate Risk Management... 919-684-6226
Musculoskeletal Disorders (MSDs) Develop over time and can take a long time to heal Can be quite painful and reduce overall effectiveness and efficiency Occur in any part of the body A variety of risk
More informationLead Exposure Management Plan
Lead Exposure Management Plan 1.0. Policy CSUF has developed the Lead Exposure Management Plan to reduce occupational and environmental exposure to lead, a potent neurotoxin and carcinogen that causes
More informationHealth Sciences Campus Biomedical Waste Management Standard Operating Procedure (SOP)
Health Sciences Campus Biomedical Waste Management Standard Operating Procedure (SOP) NOTE: This SOP for biological waste management does not supersede the requirements for radioactive and/or hazardous
More informationGUIDANCE ON THE SAFE HANDLING OF MONOCLONAL ANTIBODY (mab) PRODUCTS
GUIDANCE ON THE SAFE HANDLING OF MONOCLONAL ANTIBODY (mab) PRODUCTS 5 th Edition November 2015 NHS Pharmaceutical Quality Assurance Committee 2015 British Oncology Pharmacists Association Pharmaceutical
More informationAppendix J IBC Biohazard Spill Management Plan
OVERVIEW Prevention is the most important part of any spill management plan. Be sure to read and understand standard operating procedures (SOP s) and protocols for safe manipulation of biohazards before
More informationResponse to Biological Spills in the Laboratory (Intentional or Accidental)
Response to Biological Spills in the Laboratory (Intentional or Accidental) Exposure Management For splash to eyes, mucous membranes, or broken area of the skin Irrigate eyes with clean water, saline or
More informationCarnegie Mellon University s Policy and Procedures for Recombinant and Synthetic Nucleic Acid Materials Spills
Carnegie Mellon University s Policy and Procedures for Recombinant and Synthetic Nucleic Acid Materials Spills Background In accordance with Section IV-B-2-b-(6) of the NIH Guidelines for Research Involving
More informationThe following standard practices, safety equipment, and facility requirements apply to BSL-1:
Section IV Laboratory Biosafety Level Criteria The essential elements of the four biosafety levels for activities involving infectious microorganisms and laboratory animals are summarized in Table 1 of
More informationBiosafety Level 2 Criteria
Biosafety Level 2 Criteria Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition Biosafety Level 2 (BSL-2): Biosafety Level 2 builds upon BSL-1. BSL-2 is suitable for work involving
More informationTEPP Planning Products Model Procedure
TEPP Planning Products e for Properly Handling and Packaging Potentially Radiologically 02B00215-13.p65 Prepared for the Department of Energy Office of Transportation and Emergency Management table of
More informationLab PPE Guide Examples of Personal Protective Equipment
Lab PPE Guide Examples of Personal Protective Equipment 1140 South Paulina St. 245 (PSB) Chicago IL 60612 Phone: 312-413-3387 Fax: 312-413-3700 www.uic.edu/depts/envh This document is to be used as a supplement
More informationUCLA Henry Samueli School of Engineering and Applied Science STANDARD OPERATING PROCEDURE MEDICAL WASTE (BIOHAZARD WASTE) MANAGEMENT
UCLA Henry Samueli School of Engineering and Applied Science STANDARD OPERATING PROCEDURE MEDICAL WASTE (BIOHAZARD WASTE) MANAGEMENT PURPOSE The purpose of this document is to specify the procedures used
More informationBiosafety Spill Response Guide
Yale University Office of Environmental Health & Safety Biosafety Spill Response Guide Office of Environmental Health & Safety 135 College Street, 1 st Floor, New Haven, CT 06510 Telephone: 203-785-3550
More informationTITLE: Storage and Management of Hazardous Medications & Chemicals APPLIES TO: Pharmacy Staff
Administrative Policies and Procedures for MOH hospitals /PHC Centers NO. OF PAGES: ORIGINAL DATE: REVISION DATE : 1.0 PURPOSE 1.1 To develop a set of safety rules and regulations that address the identification,
More informationBiological Safety Program
Risk Management & Safety Main Office, Wyoming Hall Phone: (307) 766-3277 Fax: (307)766-6116 Regulated Materials Management Center Phone: (307)766-3696 Fax: (307)766-3699 Web: www.uwyo.edu/ehs Email: UWEHS@uwyo.edu
More informationThis course was written for RN.ORG by an outside consultant and RN.ORG has rights for distribution but is not responsible for the contents.
Safe Handling of Hazardous Drugs WWW.RN.ORG Reviewed September, 2015, Expires September, 2017 Provider Information and Specifics available on our Website Unauthorized Distribution Prohibited 2015 RN.ORG,
More informationScott & White Institutional Biosafety Committee Compliance Program Biohazardous Material Spill Clean-Up Procedure Policy #IBC.002
I. Purpose Biohazardous material usage on the Scott & White campus is regulated by the Scott & White Institutional Biosafety Committee (IBC). Those investigators choosing to perform research with biohazardous
More informationSAFE HANDLING OF HAZARDOUS MEDICATIONS. Cytotoxic and Non-Cytotoxic. Winnipeg Regional Health Authority Policy # 110.160.010
SAFE HANDLING OF HAZARDOUS MEDICATIONS Cytotoxic and Non-Cytotoxic Winnipeg Regional Health Authority Policy # 110.160.010 By the end of this presentation staff should be able to 1. Understand what information
More informationRMM 501 Hazardous Materials Management Systems Including WHMIS Program Page 2 November 2014
RMM 501 Hazardous Materials Management Systems Including WHMIS Program Page 2 3.4 McMaster University RMM #300 Safety Orientation and Training Program 3.5 McMaster University RMM #301 Standard Operating
More informationAdeno-Associated Viral Vectors
Adeno-Associated Viral Vectors Background Adeno-associated viruses (AAV) are single strand DNA viruses that require a helper virus (typically adenovirus, herpesvirus and vaccinia) to replicate. When there
More informationPI s Name Date Bldg./Rm# CDC Biosafety Level 3 (BSL-3)
PI s Name Date Bldg./Rm# CDC Biosafety Level 3 (BSL-3) Yes No 1. Is access to the laboratory limited or restricted at the discretion of the laboratory director when experiments are in progress? Yes No
More informationBiosafety Level 2 (BSL-2) Safety Guidelines
BLS-4 Biosafety Level 2 (BSL-2) Safety Guidelines BSL-3 BSL-2 BSL-1 BSL-2 builds upon BSL-1. If you work in a lab that is designated a BSL-2, the microbes used pose moderate hazards to laboratory staff
More informationFREQUENTLY ASKED QUESTIONS
FREQUENTLY ASKED QUESTIONS 1. What are all these acronyms & abbreviations? 2. What is the Animal Welfare Assurance Number for Rosalind Franklin University for grant submission? 3. Do I need an Animal Protocol?
More informationDivision of Public Health Administrative Manual
PURPOSE To establish a protocol for the development of a written Division of Public Health Hazard Communications Program at each applicable office or laboratory workplace and to assure that employees are
More informationDacarbazine for Injection, USP Dacarbazine Antineoplastic
MATERIAL SAFETY DATA SHEET SECTION 1 - PRODUCT & COMPANY IDENTIFICATION 1501 East Woodfield Road Suite 300 East Schaumburg, IL 60173 (847) 969-2700 Product Identifier: Chemical Name: Category: Emergency
More informationTools for Policy Development: Recommendations for handling linens exposed to hazardous drugs
Tools for Policy Development: Recommendations for handling linens exposed to hazardous drugs What is your laundry s policy for handling linens that may have been exposed to hazardous drugs? This question
More informationSPILL RESPONSE PROCEDURE
SPILL RESPONSE PROCEDURE Queen's University Spill Response Procedure May 2000 1 SOP-HAZMAT-01 1.0 Preamble This document outlines emergency spill response procedures as part of the overall Queen's University
More informationHazard Communication Program "RIGHT TO KNOW"
Hazard Communication Program Your "RIGHT TO KNOW" Hazard Communication Program OSHA Standard 1910.1200 Your "RIGHT TO KNOW" This standard requires that our hospital maintain a written safety plan describing
More informationEOSMS 204C Effective Date: 12/8/2014 Page 1 of 8
EOSMS 204C Effective Date: 12/8/2014 Page 1 of 8 1. Purpose This Standard Operating Procedure (SOP) establishes procedures for the safe handling, transportation and storage of (MC), which is also known
More informationHazard/Risk Identification and Control Procedure
Hazard/Risk Identification and Control Procedure Introduction Hazard identification and the steps taken to minimize the risks associated with identified hazards are a critical component of working safely.
More informationFile: Spill Response Plan for Hazard Chemicals and Mercury Spills. Orig. Date: 12/01/2005 Review Date: January Review Date: March 2010
File: Spill Response Plan for Hazard Chemicals and Mercury Spills Orig. Date: 12/01/2005 Review Date: January Review Date: March 2010 OSHA: 1910.120 EPA: 40CFR 112.7 Messiah College Spill Response Policy
More informationHAZARD COMMUNICATION & THE GLOBAL HARMONIZING SYSTEM EMPLOYEE TRAINING
HAZARD COMMUNICATION & THE GLOBAL HARMONIZING SYSTEM EMPLOYEE TRAINING This easy-to-use Leader s Guide is provided to assist in conducting a successful presentation. Featured are: INTRODUCTION: A brief
More informationParticularly Hazardous Substances (PHS) Standard Operating Procedure (SOP)
Particularly Hazardous Substances (PHS) Standard Operating Procedure (SOP) Formaldehyde, formalin, paraformaldehyde solutions, and paraformaldehyde solids Principal Investigator: Room & Building #: Department:
More informationSafe Handling of Cytotoxic Materials
Safe Handling of Cytotoxic Materials Kara Henman RN, MN, CON(C) Oncology Practice Consultant Cancer Care Nova Scotia What are hazardous drugs? Chemotherapy Immunosuppressive agents Biological agents Antiviral
More informationStudent Shop Safety Policy GS92 Page 1
Policy Subject: Student Shop Safety Effective: 8/1/2012 Affected Area: Machine Shops on Campus Reviewed/Revised: 8/1/2012 1.0 Purpose, Applicability, and Scope 1.1 Purpose- This policy identifies the requirements
More informationSafe Operating Procedure
Safe Operating Procedure (Revised 12/11) SPILL AND EXPOSURE RESPONSE FOR BIOHAZARDOUS MATERIALS (INCLUDING RECOMBINANT NUCLEIC ACIDS) (For assistance, please contact EHS at (402) 472-4925, or visit our
More informationSection 4. Toxicology
Section 4 Toxicology Occupational Health Any chemical you use incorrectly can result in over-exposure leading to adverse health effects immediately or in the future. All hazardous materials can be handled
More informationCytotoxic Agents Safe Management For Nursing Students. Pat Stalker Clinical Educator, LRCP Feb 2015
Cytotoxic Agents Safe Management For Nursing Students Pat Stalker Clinical Educator, LRCP Feb 2015 Overview and Objectives Review key content of the nursing procedure Differentiate between Hazardous drugs
More informationGEORGIA INSTITUTE OF TECHNOLOGY ENVIRONMENTAL HEALTH AND SAFETY PERSONAL PROTECTIVE EQUIPMENT
PURPOSE To protect the health and welfare of GEORGIA TECH employees in areas where there may be a risk of injury or exposure to hazardous substances or conditions employees who work in areas where physical
More informationRecommendations for the Safe Use of Handling of Cytotoxic Drugs
Recommendations for the Safe Use of Handling of Cytotoxic Drugs Introduction Cytotoxic drugs are toxic compounds and are known to have carcinogenic, mutagenic and/or teratogenic potential. With direct
More informationHazardous Precautions. Prepared By: Hazardous Precautions Working Group Updated: March 2014
Hazardous Precautions Prepared By: Hazardous Precautions Working Group Updated: March 2014 1 What are Hazardous Medications? They are therapeutic agents that are often used in the treatment of: cancer,
More informationARTICLE 11 HEALTH AND SAFETY
ARTICLE 11 HEALTH AND SAFETY A. UNIVERSITY AND EMPLOYEE COMMITMENT TO HEALTH AND SAFETY 1. The University of California is committed to providing all employees a safe work environment. 2. The University
More informationIPM Plan for Campus Landscape
Created June 2014 IPM Plan for Campus Landscape Statement of Purpose The purpose of this integrated pest management (IPM) plan is to guide the use of environmentally sensitive pest management strategies
More informationBiosafety Program University of Colorado. BSL-1 Audit Checklist
PI first name: PI last name: username: IBC application #: Inspection Date: Lab Location: Department: email: best lab contact lab contact email Inspected by: Time BSL-1 Yes BSL-2 Yes A. Contamination Control
More informationProcedure: Hazardous Materials Medical Support and Rehabilitation Functions
Procedure: HAZARDOUS MATERIALS MEDICAL SUPPORT Purpose: This standard operating procedure requires that a medical support function be designated to the Hazardous Materials Group during all operations within
More informationRisk Assessment: Biosafety Cabinet
Risk Assessment: Biosafety Cabinet Biosafety cabinets (BSCs) serve as primary containment devices for operations involving potential splashes, spills or aerosolization of hazardous biological materials.
More informationBiosafety Guidelines. 5. Pipetting Mechanical pipetting devices must be available and used. Mouth pipetting is prohibited.
Biosafety Guidelines Biosafety Level 1 Laboratory Biosafety Level 1 is suitable for work involving well-characterized agents not known to consistently cause disease in immunocompetent adult humans, and
More informationNorth Carolina State University Emergency Facilities Closure Checklist- Part I
North Carolina State University Emergency Facilities Closure Checklist- Part I Unplanned or spontaneous events often disrupt daily operations on campus. In the event that an incident may interrupt your
More informationR.E.D. FACTS. Chloroxylenol. Pesticide Reregistration. Use Profile. Regulatory History
United States Prevention, Pesticides EPA-738-F-94-028 Environmental Protection And Toxic Substances September 1994 Agency (7508W) R.E.D. FACTS Pesticide Reregistration Use Profile Regulatory History Chloroxylenol
More informationSafe Handling of Oral Chemotherapy. Rick Abbott Regional Pharmacy Manager, Systemic Therapy Eastern Health, NL Rick.abbott@easternhealth.
Safe Handling of Oral Chemotherapy Rick Abbott Regional Pharmacy Manager, Systemic Therapy Eastern Health, NL Rick.abbott@easternhealth.ca Conflict of Interest Declaration I have developed and delivered
More informationPOLICY 08:18:00 BLOODBORNE PATHOGENS CONTROL PLAN
POLICY 08:18:00 BLOODBORNE PATHOGENS CONTROL PLAN I. Purpose and Scope The purpose of this plan is to establish guidelines and precautions for the handling of materials which are likely to contain infectious
More informationChemotherapy: Safety Protocols. Janet Modrakovic, BAS, CVT
Chemotherapy: Safety Protocols Janet Modrakovic, BAS, CVT The word chemotherapy strikes fear in the heart of every pet owner whose beloved pet has been diagnosed with cancer. The incidence of cancer in
More information1. Organization and Management of UNR Safety Programs
WRITTEN WORKPLACE SAFETY PLAN University of Nevada, Reno 1. Organization and Management of UNR Safety Programs Administrative Responsibilities Final responsibility for maintenance of campus safety and
More informationSafe Handling of Hazardous Drugs
Safe Handling of Hazardous Drugs Staff Education May 1, 2015 Safe Handling of Hazardous Drugs Most hospitals have policies & procedures for the handling of cytotoxic drugs (chemotherapy) But what about
More informationEMERGENCIES. Emergencies
Emergencies A good safety program, training, and use of precautions reduce the number and seriousness of accidents. Laboratory accidents can range from fires to chemical spills to spills and falls. Your
More informationLaboratory Work Risk Assessment
1. Introduction Laboratory Work Risk Assessment The legislation governing Hazardous Substances and Dangerous Goods requires that all operations and experiments involving hazardous materials must have documentation
More informationMATERIAL SAFETY DATA SHEET
Page 1 of 6 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Pfizer Inc Pfizer Pharmaceuticals Group 235 East 42nd Street New York, New York 10017 1-212-573-2222 Emergency telephone
More informationFacility Safety Plan State University of New York Upstate Medical University
Facility Safety Plan State University of New York Upstate Medical University A. Research Operations / Standard Operating Procedure The State University of New York Upstate Medical University maintains
More informationBSL 1 Laboratory Biosafety Manual
BSL 1 Laboratory Biosafety Manual Version 1.0 Idaho State University, Office for Research Institutional Biosafety Committee (IBC) 1651 Alvin Ricken Drive, Pocatello, ID 83201-8046 Phone: 208-282-2179 Fax:
More informationPROJECT HAZARD ASSESSMENT FORM CHEMICAL HAZARDS
PROJECT HAZARD ASSESSMENT FORM PI/SPONSOR: Completion of the following form will serve as a risk assessment, personal protective equipment (PPE) assessment and guide to required training for the activities
More information2015 -- S 0169 S T A T E O F R H O D E I S L A N D
======== LC000 ======== 01 -- S 01 S T A T E O F R H O D E I S L A N D IN GENERAL ASSEMBLY JANUARY SESSION, A.D. 01 A N A C T RELATING TO INSURANCE - ACCIDENT AND SICKNESS INSURANCE POLICIES Introduced
More informationStandard Operating Procedure for a Chemical Spill
Standard Operating Procedure for a Chemical Spill Facility: Lab Director: Scope: ERC Clean Room C17 Engineering Research Complex Electrical and Computer Engineering Brian Wright 3234 Engineering 355-5233
More informationMATERIAL SAFETY DATA SHEET
MATERIAL SAFETY DATA SHEET 1. PRODUCT IDENTIFICATION 1.1 Product Name: Cyanogen Bromide Fibrinogen Fragments 1.2 Product REF: 459 1.3 Configuration: One (1) vial, 5.0 mg, lyophilized 1.4 Use of Product:
More informationRequired Biosafety Level Three (BSL-3) Practices, Procedures, Facilities, and Safety Equipment For BSL-3 and BSL3/2 Laboratories
Required Biosafety Level Three (BSL-3) Practices, Procedures, Facilities, and Safety Equipment For BSL-3 and BSL3/2 Laboratories 1) LABORATORY OPERATIONS a) Responsibilities: A clear organization is set
More informationPERSONAL PROTECTIVE EQUIPMENT (PPE)
Page 1 of 6 (PPE) Personal protective equipment (PPE) is used to protect an individual from hazards associated with their work tasks or environment. Specific types of personal protective equipment include
More informationMATERIAL SAFETY DATA SHEET
Page 1 of 6 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Pfizer Inc Pfizer Pharmaceuticals Group 235 East 42nd Street New York, New York 10017 1-212-573-2222 Emergency telephone
More informationAPPENDIX A. Contamination (feet, leg, clothing, eyes, hands)
APPENDIX A Laboratory PPE Hazard Assessment Tool (This tool is available online at https://ehsis.yale.edu/ehsintegrator/survey/labppe) Check all Activities/Jobs/tasks that apply to your laboratory, and
More informationSierra Leone Emergency Management Program Standard Operating Procedure for Safe, Dignified Medical Burials
Sierra Leone Emergency Management Program Standard Operating Procedure for Safe, Dignified Medical Burials Approved By: Burial Pillar Date Approved: 24 February 2015 Version 2 Page 1 of 8 Table of Contents
More informationPRODUCT ID: LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE INJECTION
SECTION 15: REGULATORY INFORMATION This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the
More informationDepartment of Environmental Health and Safety & Emergency Management
Date: February 2014 Revision: 02 Page: 1 of 13 This Guideline is issued jointly by the Department of Environmental Health and Safety & (EHSEM) and Facilities Management to provide guidance and consistency
More informationModel Policy Statement for Integrated Pest Management in Schools and Child Care Facilities
Model Policy Statement for Integrated Pest Management in Schools and Child Care Facilities School Pest Management Policy Statement Structural and landscape pests can pose significant problems in the urban
More informationProcedure for Visitors in UIC Laboratories
Procedure for Visitors in UIC Laboratories 1129 S. Hermitage, Chicago, IL 60612-7217 Office: (312) 996-7411 OBJECTIVE In order to protect the Principal Investigator (PI) and the University of Illinois
More informationNDSU Guidelines for Occupational Health & Safety 1 (1997; rev. 2001, 2005, 2006, 2007, 2011, 2013, 2014, 2015)
Guidelines for Occupational Health and Safety in the Care and Use of Animals University Police and Safety Office, Office of the Vice President for Finance and Administration Auxiliary Enterprises Dept.
More informationBritish Columbia Cancer Agency
Page 1 of 8 RATIONALE To minimize the hazardous drug exposure of staff, patients and visitors to the BCCA Regional Centres, spills must be managed appropriately, according to established policies and procedures.
More informationKnowledge and Awareness of Proper Waste Disposal and Routine Biosafety Measures Among HealthCare Workers in Karachi, Pakistan (JUW-BEP-BSAP Project)
Knowledge and Awareness of Proper Waste Disposal and Routine Biosafety Measures Among HealthCare Workers in Karachi, Pakistan (JUW-BEP-BSAP Project) 11/01/2011 1 Shazia Tabassum Hakim 1,4, Syed Muhammad
More information4729-16-11 Hazardous Drugs Compounded by a Prescriber.
ACTION: Original DATE: 11/30/2015 8:57 AM 4729-16-11 Hazardous Drugs Compounded by a Prescriber. (A) A facility where a prescriber is compounding or handling hazardous drugs shall be licensed as a terminal
More informationKEY CAL/OSHA STANDARDS THAT APPLY TO MOST EMPLOYERS
KEY CAL/OSHA STANDARDS THAT APPLY TO MOST EMPLOYERS FACTSHEET 1 Below are some key Cal/OSHA standards that apply to most employers: A. INJURY AND ILLNESS PREVENTION PROGRAM STANDARD (Title 8 California
More informationBOSTON COLLEGE ENVIRONMENTAL HEALTH AND SAFETY LABORATORY GUIDE FOR RENOVATIONS, REMODELS, MOVES AND TERMINATIONS
BOSTON COLLEGE ENVIRONMENTAL HEALTH AND SAFETY LABORATORY GUIDE FOR RENOVATIONS, REMODELS, MOVES AND TERMINATIONS I. Policy for Termination of Laboratory Use of Hazardous Materials The Principal Investigator
More informationEMPLOYEE SAFETY TRAINING PROCEDURE
UNIVERSITY OF ALASKA FAIRBANKS SAFETY SYSTEM POLICY AND PROCEDURE DOCUMENT NUMBER: 301 ISSUE DATE: SEPTEMBER 1996 REVISION DATE: APRIL 2003 SUBJECT: Employee Safety Training Procedure EMPLOYEE SAFETY TRAINING
More informationCDC Import Permit Inspection Checklist for ABSL-3 Laboratories (BMBL 5th Edition)
CDC Import Permit Inspection Checklist for ABSL-3 Laboratories (BMBL 5th Edition) Entity Name: Street Address: City, State, Zip: Lead Inspector: Other Inspectors: Building/Room(s): PI(s): Entity Name:
More informationRisk Assessment Instructions
Assessment Instructions This document provides guidance on completing the laboratory task based risk assessment. It includes the process for identifying hazards for the task and the controls to reduce
More informationSpill Kits and Incidental Spill Response
Spill Kits and Incidental Spill Response June 2012 This training is intended to be educational and should not be construed as legal guidance. It is provided as a courtesy to our customers and others who
More informationBLOODBORNE PATHOGENS EXPOSURE CONTROL PLAN
BLOODBORNE PATHOGENS EXPOSURE CONTROL PLAN Facility Name: University of Arkansas at Little Rock Date of Preparation: 01-17-06 In accordance with the OSHA Bloodborne Pathogens Standard, 1910.1030, the following
More informationSeptember 19, 1984 FOOD PRODUCTION AND DIRECTION GÉNÉRALE, SECTION INSPECTION BRANCH PRODUCTION ET INSPECTION PESTICIDES DES ALIMENTS TRADE MEMORANDUM
Agriculture Canada September 19, 1984 T-1-245 FOOD PRODUCTION AND DIRECTION GÉNÉRALE, SECTION INSPECTION BRANCH PRODUCTION ET INSPECTION PESTICIDES DES ALIMENTS TRADE MEMORANDUM RE: Guidelines for Developing
More informationELIZABETH CITY STATE UNIVERSITY Compliance Policies and Procedures
ELIZABETH CITY STATE UNIVERSITY Compliance Policies and Procedures Preamble Elizabeth City State University (ECSU) pursues federal, state and local resources to support teaching, research and community
More information