Transfusion and Stem Cell and Solid Organ Transplantation: Issues and Solutions

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Transfusion and Stem Cell and Solid Organ Transplantation: Issues and Solutions"

Transcription

1 Transfusion and Stem Cell and Solid Organ Transplantation: Issues and Solutions Hedyeh Shafi, M Objectives: escribe the different phases of transfusion support in hematopoietic stem cell transplantation escribe challenges associated with ABO-incompatible hematopoietic stem cell transplantation Understand the mechanism for Passenger Lymphocyte Syndrome efinitions Hematopoietic Stem Cell(HSC)- immature cells that have the potential to divide and also mature into all hematopoietic cell Hematopoietic Progenitor Cell(HPC)- More mature cells that initially maintain the capacity to renew, but also become committed to a cell line type (eg. Myeloid or lymphoid lineage) Shafi, Heidi 1

2 efinitions Hematopoietic Stem Cell Transplant (HSCT)- the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow (HPC-M), peripheral blood (HPC-A), or umbilical cord blood (HPC-C), from a donor to a recipient. Autologous- the patient's own stem cells are used Allogeneic- the stem cells come from a donor efinitions Engraftment- dynamic cellular process of stem cells homing and differentiating in a recipient (should occur within 100 days of transplant) Graft Failure- Loss of function or failure to gain function of the transplanted organ or tissue Allogeneic onor Compatibility Human Leukocyte Antigen (HLA) compatibility- most important HLA-A, HLA-B, HLA-C, HLA-RB1 HPCs express HLA Antigens ABO incompatible transplants are possible HPCs don t express ABO Antigens Shafi, Heidi 2

3 Compatibility for HSCT by ABO Blood Group of onor and Recipient: Szczepiorkowski ZM. Core Principles in Cellular Therapy. Bethesda, M, AABB, 2008: Compatibility for HSCT by ABO Blood Group of onor and Recipient: Recipient ABO Group onor ABO Group O A B AB O Identical Major Major Major A Minor Identical Bidirectional Major B Minor Bidirectional Identical Major AB Minor Minor Minor Identical Phase I - from the time patient/recipient is prepared for HPC transplant until initiation of transplant Phase II - from the initiation of chemotherapy until engraftment Phase III - after engraftment; when the front and back type of the patient/recipient is consistent with donor's ABO group Shafi, Heidi 3

4 Phase I - from the time patient/recipient is prepared for HPC transplant until initiation of transplant Prevent HLA immunization (leukocyte-reduced products) Prevent Graft vs. Host isease- Irradiated blood products CMV-negative products* Transfuse all components per recipient ABO group* For incompatible transplants- consider giving type O PRBCs or recipient type products Phase II - from the initiation of chemotherapy until engraftment: Prevent HLA immunization (leukocyte-reduced products) Prevent Graft vs. Host isease- Irradiated blood products CMV-negative products For ABO-mismatched transplants transfuse all components per following table Recipeint Type onor Type Red Cell Type FFP/PLT Type O A O A, AB O B O B, AB O AB O AB A AB A,O AB B AB B,O AB A O O A, AB B O O B, AB AB O O AB AB A A, O AB AB B B, O AB A B O AB B A O AB Shafi, Heidi 4

5 Major ABO Incompatibility: Issues: Immediate: Hemolysis of the infused donor red cells within the graft elayed: Hemolysis of red cells produced by engrafted marrow (recipient ABO antibodies may persist 3-4 mo) elayed onset of erythropoiesis (40-60 days) Pure red-cell aplasia Major ABO Incompatibility: Solutions: Red cell removal from the graft during collection or processing Red cell depletion (HPC-M, HPC-C, HPC-A (only a few red cells)) Cryopreservation (HPC-C) ABO antibody reduction using apheresis Rarely needed Transfuse components compatible with donor and recipient Red Cell epletion Method Advantage isadvantage Hetastarch Errors other than leakage are recoverable Not extremely operator dependent Closed system Non-toxic Hetastarch with centrifugation Same advantages as hetastarch alone Rapid processing for time critical procedures Good for smaller volumes Cell Washer Closed system Errors other than leakages are recoverable ensity Gradient Common equipment Open system Long sedimentation period Citrate-containing anticoagulants interfere with rouleaux formation Increased risk of bag breakage due to centrifugation ifficult for large volume products Citrate-containing anticoagulants interfere with rouleaux formation Time Older technology Requires investment in equipment Usually reserved for research use or processing of products under an IN, not routine clinical use Operator dependent Known toxicity to cells Cell Washer with ensity Gradient Closed system Large volume Errors other than leakages are recoverable Time Older technology Requires investment in equipment SEPAX II Automated Closed system Good Recovery Can be used for both RBC and plasma depletion Requires investment in equipment Machine processes one unit at a time Adapted from RBC epletion by eborah L. Griffin, MS Shafi, Heidi 5

6 Minor ABO Incompatibility: Issues: Immediate: Hemolysis of recipient s red cells upon infusion of donor ABO antibodies within the graft Mild and Self-limited elayed: Hemolysis (5-16 days after infusion of HPCs), due to rapid generation of antibodies by donor lymphocytes (passenger B-cells) Minor ABO Incompatibility: Solutions: Plasma depletion Recipient's dilution of red cells by RBC exchange using donor compatible RBCs Transfuse components with plasma which is compatible with donor and recipient RBCs Bidirectional ABO Incompatibility: Issues: Immediate: Hemolysis caused by donor and/or recipient s red cells antibodies elayed: Hemolysis caused by donor and/or recipient s red cells antibodies elayed engraftment of RBCs Pure red cell aplasia Shafi, Heidi 6

7 Bidirectional ABO Incompatibility: Solutions: Combination of practice used in minor and major ABO incompatibility: Red cell depletion Plasma depletion Incompatibility Related to Non-ABO Antigens Less frequent than those related to ABO Antigens Red Cell Antibodies in Recipient Red Cell Antibodies in onor (less common) Phase III after engraftment; when the front and back type of the patient/recipient is consistent with donor's ABO group Prevent HLA immunization (leukocyte-reduced products) Prevent Graft vs. Host isease- Irradiated blood products CMV-negative products Transfuse all components per donor ABO group Shafi, Heidi 7

8 Red blood cells: 7g/dl in stable, non-postoperative adult HSCT recipient 8g/dl for adults with preexisting heart disease and/or at risk of end organ damage Platelets: 10,000 /ul for prophylaxis 20,000/uL in febrile patients* 50,000/uL in bleeding patients Platelet Refractoriness: Issues: HLA-alloimmunization is observed in 7% to 34% of hematooncologic patients Increases platelet transfusion requirements Increases risk of delayed bleeding post transplant Solutions: Transfusion of antigen-negative, cross-matched or HLAmatched platelets Prevention is the best solution! Shafi, Heidi 8

9 Plasma and Cryoprecipitate: No specific recommendations Solid Organ Transplantation and Transfusion A 57 yo male (blood type B-) with end stage liver disease receives a liver transplant from a O- deceased donor. He has a relatively uneventful postoperative period, however by postoperative day 15 his total bilirubin has slowly increased to 8.2 mg/dl. Clinical team is concerned and orders a few more tests, and consults Transfusion Medicine. What do you think are their main concerns? Shafi, Heidi 9

10 Solid Organ Transplantation In 2014: 29, 533 transplants in US Solid Organ Transplantation ABO compatibility is the most important ABO incompatible transplants are possible (eg. Kidney transplants) Require desensitization of recipient through plasma exchange and immunosuppressive therapies Use of A2 donor organs Transfusion Support in Solid Organ Recipients Prevent HLA immunization (leukocyte-reduced products) CMV-negative products for CMV negative recipients receiving CMV-negative organs Transfusion requirements: Liver>Heart>Kidney Shafi, Heidi 10

11 Transfusion Support in Solid Organ Recipients Liver Transplants Red Cells, Plasma and Platelets Rh () type switch Alloimmunization to RBC antigens Use antigen (-) units at the beginning and end If necessary use antigen (+) units in the middle Inventory management: For A and O patients use ABO identical RBCs For AB patients, consider using Type A RBCs For B patients, consider using Type O RBCs Communication between Transplant team and Blood bank is Key! Transfusion Strategy for ABO Mistmatched Solid Organ Transplants Recipient onor RBCS Plasma/Platelets O A B AB A O A, AB B O B, AB AB O AB B O AB AB A,O AB O O A, AB A O AB AB B,O AB O O B, AB A A,O AB B B,O AB O O AB A 57 yo male (blood type B-) with end stage liver disease receives a liver transplant from a O- deceased donor. He has a relatively uneventful postoperative period, however by postoperative day 9 his total bilirubin has slowly increased to 8.2 mg/dl. Clinical team is concerned and orders a few more tests, and a consult from Transfusion Medicine. What do you think are their main concerns? hemoglobin level is 5.8g/dl Shafi, Heidi 11

12 R O- donor RBCs onor B-lymphocytes Recipient B- RBCs onor anti-b antibodies 1-2 weeks later R R R R R R Passenger Lymphocyte Syndrome (PLS) Immune-mediated hemolysis following ABO mismatched solid organ and/or bone marrow transplantation Most often seen in transplantation with a minor ABO mismatch Mediated by donor B-lymphocytes Occurs 7-10 days post transplantation Usually resolves with 4 weeks (some report cases up to 3 mos) Patient may require transfusions and steroids To avoid PLS, transfuse O RBCs in the post transplant period PLS Involving Non-ABO Antibodies A 58 yo male (blood type O+) with CML received a stem cell transplant from A- donor who had an identifiable anti-. Stem cell product was plasma reduced prior to infusion. On post transplant day 8, he developed significant hemolysis and the antibody screen and direct antiglobulin test were positive. Post Transplant ay Hemoglobin (g/dl) LH (IU) Total Bilirubin (mg/dl) Antibody Screen irect Antiglobulin Test Eluate Negative Negative Not one 4 Negative Negative Not one Positive Positive Anti Positive Positive Anti- Anti- was still present 12 months after the transplant. Transfus Med Hemother Apr;41(2): Shafi, Heidi 12

13 References: 1. Szczepiorkowski ZM. Core Principles in Cellular Therapy. Bethesda, M, AABB, 2008: Cohn CS, Transfusion support issues in hematopoietic stem cell transplantation. Cancer Control Jan;22(1): Cunard R, Marquez II, Ball E, Nelson CL, Corringham S, Clopton P, Sanchez AP, Lane T, Ward M. Prophylactic red blood cell exchange for ABO-mismatched hematopoietic progenitor cell transplants. Transfusion Jul;54(7): Solves P, Mirabet V, Roig R. Volume reduction in routine cord blood banking. Curr Stem Cell Res Ther ec;5(4): Bonstein L 1, Stemer G, ann EJ, Zuckerman T, Fineman R, Haddad N. Alloimmune platelet transfusion refractoriness circumvented by allogeneic stem cell transplantation. Transfusion May;53(5): Romero S, Solves P, Lancharro A, Cano I, Moscardó F, Carpio N, Sanz MA. Passenger lymphocyte syndrome in liver transplant recipients: a description of 12 cases. Blood Transfus July;13(3): Squires JE. Passenger Lymphocyte Syndrome: A Case Report Involving Non-ABO Antibodies. Transfus Med Hemother Apr;41(2): Fung MK, editor. Technical Manual, 18 th ed. Bethesda, M: American Association of Blood Banks; Shafi, Heidi 13

TRANSFUSION SUPPORT FOR HEMOTOPOIETIC STEM CELL TRANSPLANT (HSCT) PATIENTS. Shan Yuan, MD Updated April 2011

TRANSFUSION SUPPORT FOR HEMOTOPOIETIC STEM CELL TRANSPLANT (HSCT) PATIENTS. Shan Yuan, MD Updated April 2011 TRANSFUSION SUPPORT FOR HEMOTOPOIETIC STEM CELL TRANSPLANT (HSCT) PATIENTS Shan Yuan, MD Updated April 2011 Introduction HSCT increasingly performed with better clinical outcomes, and expanding indications.

More information

Selecting Appropriate Blood Products for Recipients of ABO/Rh Mismatched Stem Cell Transplants. Summary of Significant Changes. Purpose.

Selecting Appropriate Blood Products for Recipients of ABO/Rh Mismatched Stem Cell Transplants. Summary of Significant Changes. Purpose. This Specification replaces SPN/DDR/RC/023/05 (SPN215/1) Copy Number Summary of Significant Changes Change to new document reference numbers. Effective 18/10/11 Removal of ABO titres from sections 3.1

More information

Stem Cell Transplantation

Stem Cell Transplantation Harmony Behavioral Health, Inc. Harmony Behavioral Health of Florida, Inc. Harmony Health Plan of Illinois, Inc. HealthEase of Florida, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance

More information

TRANSFUSION MEDICINE

TRANSFUSION MEDICINE TRANSFUSION MEDICINE Transfusion medicine is a one-month per year rotation for a total of three months. During each rotation the resident is exposed to the basic concepts of transfusion medicine. Specific

More information

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points

Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Bone Marrow Transplantation

More information

Blood-Forming Stem Cell Transplants

Blood-Forming Stem Cell Transplants Blood-Forming Stem Cell Transplants What are bone marrow and hematopoietic stem cells? Bone marrow is the soft, sponge-like material found inside bones. It contains immature cells known as hematopoietic

More information

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CLL and SLL File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cll_and_sll

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood

Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood [Track 2: What Is a Transplant?] Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood can be an effective treatment for people with blood cancers such as leukemia,

More information

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Background Hematopoietic stem cell transplantation (HSCT) is

More information

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE HIND AL HUMAIDAN, MD,FRCPA Director, Blood Bank (Donor & Transfusion Services) and Stem Cell Cord Blood Bank Consultant Hematopathologist INTRODUCTION

More information

Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc

Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation Marianne E. McPherson Yee, MD, MSc Sickle Cell Treatment Options Supportive Care Newborn Screen PCN Immunizations Education

More information

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 COVERAGE: SPECIAL COMMENT ON POLICY REVIEW: Due to the complexity of the Peripheral and Bone Marrow Stem Cell Transplantation

More information

Exercise 9: Blood. Readings: Silverthorn 5 th ed, 547 558, 804 805; 6 th ed, 545 557, 825 826.

Exercise 9: Blood. Readings: Silverthorn 5 th ed, 547 558, 804 805; 6 th ed, 545 557, 825 826. Exercise 9: Blood Readings: Silverthorn 5 th ed, 547 558, 804 805; 6 th ed, 545 557, 825 826. Blood Typing The membranes of human red blood cells (RBCs) contain a variety of cell surface proteins called

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information

BIOSTATISTICS FOR TRANSLATIONAL & CLINICAL RESEARCH. Blood-&-Marrow Transplants & CANCERS

BIOSTATISTICS FOR TRANSLATIONAL & CLINICAL RESEARCH. Blood-&-Marrow Transplants & CANCERS BIOSTATISTICS FOR TRANSLATIONAL & CLINICAL RESEARCH Blood-&-Marrow Transplants & CANCERS Stem Cells Stem cells are immature body cells that act like "starter dough" because they can make identical copies

More information

Stem Cell Background Paper

Stem Cell Background Paper Stem Cell Background Paper Introduction...2 Stem Cell Basics...3 Stem Cell Process Flow...9 Comparison of Blood, Stem Cells, Tissues and Organs Processes...10 Responsibilities for the Blood, Stem Cells,

More information

STEM CELL TRANSPLANTS

STEM CELL TRANSPLANTS UAMS Information on STEM CELL TRANSPLANTS What is a Stem Cell Transplant? A stem cell transplant is an infusion of stem cells following high-dose chemotherapy. The infused cells effectively rescue the

More information

Cord Blood Stem Cell Transplantation

Cord Blood Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA FACTS Cord Blood Stem Cell Transplantation No. 2 in a series providing the latest information on blood cancers Highlights Umbilical cord blood, like bone marrow and peripheral

More information

CHAPTER 10 BLOOD GROUPS: ABO AND Rh

CHAPTER 10 BLOOD GROUPS: ABO AND Rh CHAPTER 10 BLOOD GROUPS: ABO AND Rh The success of human blood transfusions requires compatibility for the two major blood group antigen systems, namely ABO and Rh. The ABO system is defined by two red

More information

SEARCHING FOR A BONE MARROW DONOR

SEARCHING FOR A BONE MARROW DONOR SEARCHING FOR A BONE MARROW DONOR Angela received a bone marrow transplant from an unrelated donor to treat her non-hodgkin s lymphoma. INFORMATION FOR PATIENTS AND THEIR FAMILIES For patients who need

More information

Public Cord Blood Tissue Bank Committee on Health Care Services and Representative Peaden

Public Cord Blood Tissue Bank Committee on Health Care Services and Representative Peaden HOUSE OF REPRESENTATIVES COMMITTEE ON HEALTH CARE SERVICES ANALYSIS BILL #: HB 2337 (PCB HCS 00-07) RELATING TO: SPONSOR(S): TIED BILL(S): Public Cord Blood Tissue Bank Committee on Health Care Services

More information

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Pros and Cons of Stem Cell Sources and their availability in Africa Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Introduction The ability to perform a haematopoietic stem

More information

Public Cord Blood Banking at the National Cord Blood Program (NCBP)

Public Cord Blood Banking at the National Cord Blood Program (NCBP) Public Cord Blood Banking at the National Cord Blood Program (NCBP) A. Scaradavou, MD Medical Director, National Cord Blood Program, New York Blood Center Associate Attending, Pediatric BMT Memorial Sloan-Kettering

More information

Processing & Utilization of Cord Blood for Transplant

Processing & Utilization of Cord Blood for Transplant Processing & Utilization of Cord Blood for Transplant 2010-Jan Jan-15 Nicole L. Prokopishyn, PhD HPC Processing Laboratory Director Calgary Laboratory Services Overview Cord Blood Processing Pre-Freeze

More information

BLOOD BANK ANNUAL STATISTICS (HOSPITALS)

BLOOD BANK ANNUAL STATISTICS (HOSPITALS) New Jersey Department of Health Clinical Laboratory Improvement Services PO Box 361 Trenton, NJ 08625-0361 BLOOD BANK ANNUAL STATISTICS (HOSPITALS) County Code Number Address Name of Individual Completing

More information

HARVARD MEDICAL SCHOOL FELLOWSHIP PROGRAM IN TRANSFUSION MEDICINE CORE CURRICULUM

HARVARD MEDICAL SCHOOL FELLOWSHIP PROGRAM IN TRANSFUSION MEDICINE CORE CURRICULUM BETH ISRAEL DEACONESS MEDICAL CENTER BRIGHAM AND WOMEN'S HOSPITAL CHILDREN S HOSPITAL, BOSTON DANA FARBER CANCER INSTITUTE MASSACHUSETTS GENERAL HOSPITAL HARVARD MEDICAL SCHOOL HARVARD MEDICAL SCHOOL FELLOWSHIP

More information

Comparability of Cord Blood Units

Comparability of Cord Blood Units Comparability of Cord Blood Units John D. McMannis,, Ph.D. Professor of Cancer Medicine Director, Cell Therapy Laboratory Technical Director, UT MDAnderson Cord Blood Bank Liaison Meeting, Bethesda June

More information

Blood cells are vital to the human body

Blood cells are vital to the human body Candide FONT-SALA Blood cells are vital to the human body Red cells transport oxygen From http://www.english-online.at/biology/blood/blood-supply-and-blood-diseases.htm Red cell life span 120 days 200

More information

Automated Cord Blood Processing:

Automated Cord Blood Processing: TM Automated Cord Blood Processing: A Follow-up to the Pilar Solves Study Comparing the AXP vs the Sepax Cord Blood Processing Systems CHRISTY KIM, PETRA CRAVENS, MINDY WILKE-DOUGLAS AND MITCHEL SIVILOTTI

More information

CORD BLOOD BANKING FAQ

CORD BLOOD BANKING FAQ CORD BLOOD BANKING FAQ Cord Blood & Stem Cells Q: What is umbilical cord blood (UCB)? A: Bone marrow, peripheral blood and UCB constitute the three primary sources of stem cells. Cord blood, which, until

More information

REQUEST FOR TESTING TRANSFUSION SERVICES

REQUEST FOR TESTING TRANSFUSION SERVICES REQUEST FOR TESTING TRANSFUSION SERVICES 921 Terry Avenue Seattle, WA 98104-1256 TO REORDER FORMS CALL 425-656-3019 PSBC Tech PSBC ID / CL # Time Received See the back of this order form for sample requirements.

More information

Guidance for Industry and FDA Review Staff on Collection of Platelets by Automated Methods

Guidance for Industry and FDA Review Staff on Collection of Platelets by Automated Methods Guidance for Industry and FDA Review Staff on Collection of Platelets by Automated Methods Blood Products Advisory Committee, March 9, 2006 Steven Kleinman, MD Senior Medical Advisor, AABB Co-chair, AABB

More information

UMBILICAL CORD BLOOD, STEM CELL BANKING

UMBILICAL CORD BLOOD, STEM CELL BANKING UMBILICAL CORD BLOOD, STEM CELL BANKING Dr.Sharad Jain MD Blood Transfusion officer, & I/C Transfusion Medicine NSCB Medical College. Jabalpur.MP. Introduction: Every parent during childbirth DREAMS the

More information

1. To permit the resident to attain expertise in the methodological, diagnostic and scientific aspects of transfusion medicine and coagulation.

1. To permit the resident to attain expertise in the methodological, diagnostic and scientific aspects of transfusion medicine and coagulation. BLOOD BANK CORE ROTATION Introduction The core rotation in blood banking is designed to expose the resident to a wide range of transfusion medicine and coagulation problems and provide training in solving

More information

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program ISCT 2012 Disclosures: none The problem:

More information

Transfusion medicine clinical training and experience is provided at three major teaching hospitals.

Transfusion medicine clinical training and experience is provided at three major teaching hospitals. Blood Bank and Transfusion Medicine - Multi-institutional Rotation Residency training in Transfusion Medicine prepares a person to provide laboratory and clinical transfusion services at community basic

More information

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape GENReports: Market & Tech Analysis Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape > Enal Razvi, Ph.D. Biotechnology Analyst, Managing Director SELECTBIO US enal@selectbio.us

More information

Role of Transfusion Medicine Consultant in Peripheral Blood Stem Cell Transplant Program

Role of Transfusion Medicine Consultant in Peripheral Blood Stem Cell Transplant Program Role of Transfusion Medicine Consultant in Peripheral Blood Stem Cell Transplant Program Dr Anita Tendulkar MD(Path),DPB,DIT Associate Professor Transfusion Medicine Tata Memorial Hospital Advanced Centre

More information

Summary of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Status

Summary of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Status of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Shelley Grant Branch Chief, Blood Stem Cell Transplantation Program September 11, 2015 Overview December 20, 2005 - HRSA began

More information

Challenges of Hematopoietic Stem Cell Transplantation. Robert J. Soiffer, MD Dana Farber Cancer Institute

Challenges of Hematopoietic Stem Cell Transplantation. Robert J. Soiffer, MD Dana Farber Cancer Institute Challenges of Hematopoietic Stem Cell Transplantation Robert J. Soiffer, MD Dana Farber Cancer Institute Hematopoietic Stem Cell Transplantation Objectives Deliver sufficient chemo-radio therapy to destroy

More information

Department of Transfusion Medicine and Immunohematology

Department of Transfusion Medicine and Immunohematology Department of Transfusion Medicine and Immunohematology Activities Transfusion medicine is a multidisciplinary area concerned with the proper use of blood and blood components in the treatment of human

More information

Determining Donor Eligibility Blood Donor vs. Stem Cell Donor. Wanda Koetz, RN, HPC Clinical Nurse Lead, Memorial Blood Centers ASFA - May 7, 2015

Determining Donor Eligibility Blood Donor vs. Stem Cell Donor. Wanda Koetz, RN, HPC Clinical Nurse Lead, Memorial Blood Centers ASFA - May 7, 2015 Determining Donor Eligibility Blood Donor vs. Stem Cell Donor Wanda Koetz, RN, HPC Clinical Nurse Lead, Memorial Blood Centers ASFA - May 7, 2015 Objectives The learner will be able to: Define donor eligibility

More information

Understanding Blood Stem Cell Transplantation

Understanding Blood Stem Cell Transplantation Developed by: Donna Kerrigan, M.S. Kathryn Hollen Jeanne Kelly Brian Hollen Discusses how bone marrow produces bloodforming stem cells that include starter immune cells. When diseases like cancer or its

More information

SARASOTA MEMORIAL HOSPITAL BLOOD COMPONENT CRITERIA AND INDICATIONS SCREENING GUIDELINES

SARASOTA MEMORIAL HOSPITAL BLOOD COMPONENT CRITERIA AND INDICATIONS SCREENING GUIDELINES SARASOTA MEMORIAL HOSPITAL BLOOD COMPONENT CRITERIA AND INDICATIONS SCREENING GUIDELINES TABLE OF CONTENTS SUBJECT PAGE ADULT CRITERIA Red Blood Cells/Autologous 2 Washed Red Blood Cells 2 Cryoprecipitate

More information

Current Issues in Stem Cell Technologies. Lance D. Trainor, MD OneBlood, Inc.

Current Issues in Stem Cell Technologies. Lance D. Trainor, MD OneBlood, Inc. Current Issues in Stem Cell Technologies Lance D. Trainor, MD OneBlood, Inc. Objective: The big picture of stem cell therapy Outline: Relevant definitions History of Stem Cell Therapy Hematopoietic Stem

More information

KEY CHAPTER 14: BLOOD OBJECTIVES. 1. Describe blood according to its tissue type and major functions.

KEY CHAPTER 14: BLOOD OBJECTIVES. 1. Describe blood according to its tissue type and major functions. KEY CHAPTER 14: BLOOD OBJECTIVES 1. Describe blood according to its tissue type and major functions. TISSUE TYPE? MAJOR FUNCTIONS connective Transport Maintenance of body temperature 2. Define the term

More information

STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE

STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE What are Stem Cells? Stem cells are the basic building blocks of all the cells, tissues and organs in the human body. The role of the stem

More information

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement for the Utility of Autologous or Family Cord Blood Unit Storage (This policy statement has been approved and adopted by the WMDA board on the 25 th of May 2006) The Cord Blood Registries

More information

Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation

Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation Hematopoietic Stem Cells, Stem Cell Processing, and Joseph (Yossi) Schwartz, MD Director, Hemotherapy and Stem Cell Processing Facility E-mail: js2745@columbia.edu A 40-year old man with acute myelogenous

More information

UMBILICAL CORD BLOOD BANKING A guide for parents

UMBILICAL CORD BLOOD BANKING A guide for parents UMBILICAL CORD BLOOD BANKING A guide for parents 2 nd EDITION INTRODUCTION The cells contained in the umbilical cord blood have therapeutic value for the treatment of blood disorders and immune diseases.

More information

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases ! 21%! EUROCORD 6756 cord blood transplantations performed from 1988 to March 2010 in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases * missing center

More information

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease 1 Produced by St. Jude Children s Research Hospital Departments of Hematology, Patient

More information

STANDARD BLOOD PRODUCTS AND SERVICES

STANDARD BLOOD PRODUCTS AND SERVICES STANDARD BLOOD PRODUCTS AND SERVICES Policy NHP reimburses contracted providers for the medically necessary administration (transfusion) of blood and standard blood products. Prerequisites Authorization,

More information

DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT

DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT www.narayanahealth.org DEPARTMENT OF BONE MARROW AND STEM CELL TRANSPLANT About Narayana Health City Narayana Health, one of India's largest and the world's most economical healthcare service providers

More information

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement on the Utility of Autologous or Family Cord Blood Unit Storage The WMDA Board adopted this policy on 25 th of May 2006. Policy updated _April 2011 The Cord Blood Working Group and

More information

BLOOD COLLECTION. How much blood is donated each year and how much is used?

BLOOD COLLECTION. How much blood is donated each year and how much is used? BLOOD COLLECTION How much blood is donated each year and how much is used? Each unit of blood consists of a volume of 450-500 milliliters or about one pint. Because of the constant demand for blood, about

More information

Blood and Marrow Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA

Blood and Marrow Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA Blood and Marrow Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA Table of Contents Introduction 1 Here to Help 2 Normal Blood and Marrow 4 Overview and Types of Stem Cell Transplantation 6 Stem Cell

More information

CORD BLOOD TRANSPLANTATION STUDY EXPANDED ACCESS PROTOCOL APPENDIX A SAMPLE CONSENT FORM

CORD BLOOD TRANSPLANTATION STUDY EXPANDED ACCESS PROTOCOL APPENDIX A SAMPLE CONSENT FORM APPENDIX A SAMPLE CONSENT FORM CORD BLOOD TRANSPLANTATION (COBLT) STUDY SAMPLE CONSENT FORM FOR THE EXPANDED ACCESS PROTOCOL You (your child) are being asked to take part in a clinical research study.

More information

Immunohematology. Immunohematology. Blood Group Antigens

Immunohematology. Immunohematology. Blood Group Antigens Immunohematology Immunohematology Jeffrey S. Jhang, MD Assistant Director, Transfusion Medicine Demonstration of red cell antigen-red cell antibody reactions is the key to immunohematology Combination

More information

HPC Transplantation D. Joe Chaffin, MD Cedars-Sinai Medical Center, Los Angeles, CA

HPC Transplantation D. Joe Chaffin, MD Cedars-Sinai Medical Center, Los Angeles, CA HPC Transplantation D. Joe Chaffin, MD Cedars-Sinai Medical Center, Los Angeles, CA www.bbguy.org A. Basics of Hematopoietic Progenitor Cell Transplant 1. What s a stem cell? a. Hematopoietic stem cells

More information

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014 ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the

More information

Hematopoietic stem and progenitor cell transplants: regulation and accreditation

Hematopoietic stem and progenitor cell transplants: regulation and accreditation Pediatr Transplantation 2003: 7 (Suppl. 3): 101 108 Printed in UK. All rights reserved Copyright Ó 2003 Blackwell Munksgaard Pediatric Transplantation ISSN 1398-2265 Hematopoietic stem and progenitor cell

More information

A fact sheet UNRELATED BONE MARROW AND CORD BLOOD STEM CELL TRANSPLANTS

A fact sheet UNRELATED BONE MARROW AND CORD BLOOD STEM CELL TRANSPLANTS A fact sheet UNRELATED BONE MARROW AND CORD BLOOD STEM CELL TRANSPLANTS Each year, thousands of patients are diagnosed with diseases treatable by a blood stem cell transplant. These blood stem cells can

More information

Blood and Marrow Stem Cell Transplantation

Blood and Marrow Stem Cell Transplantation Blood and Marrow Stem Cell Transplantation Revised 2013 A Message from Louis J. DeGennaro, PhD President and CEO of The Leukemia & Lymphoma Society The Leukemia & Lymphoma Society (LLS) is committed to

More information

STANDARD OPERATING PROCEDURE FOR RESOLVING ABO & Rh BLOOD GROUP DISCREPANCIES

STANDARD OPERATING PROCEDURE FOR RESOLVING ABO & Rh BLOOD GROUP DISCREPANCIES STANDARD OPERATING PROCEDURE FOR RESOLVING ABO & Rh BLOOD GROUP DISCREPANCIES TITLE: STANDARD OPERATING PROCEDURE FOR RESOLVING ABO & RH BLOOD GROUP DISCREPANCIES 1.0 Principle 1.1 To resolve ABO and Rh

More information

SAVE A LIFE... BY GIVING LIFE!

SAVE A LIFE... BY GIVING LIFE! SAVE A LIFE... BY GIVING LIFE! FOLLOW US ON: HÉMA-QUÉBEC PUBLIC CORD BLOOD BANK www.hema-quebec.qc.ca Scan this code with your smart phone to access the page Register to the Public Cord Blood Bank on the

More information

Blood Transfusion. There are three types of blood cells: Red blood cells. White blood cells. Platelets.

Blood Transfusion. There are three types of blood cells: Red blood cells. White blood cells. Platelets. Blood Transfusion Introduction Blood transfusions can save lives. Every second, someone in the world needs a blood transfusion. Blood transfusions can replace the blood lost from a serious injury or surgery.

More information

Reference: NHS England B04/P/a

Reference: NHS England B04/P/a Clinical Commissioning Policy: Haematopoietic Stem Cell Transplantation (HSCT) (All Ages): Revised Reference: NHS England B04/P/a 1 NHS England Clinical Commissioning Policy: Haematopoietic Stem Cell Transplantation

More information

Stem Cell Transplantation in Severe Aplastic Anemia

Stem Cell Transplantation in Severe Aplastic Anemia Stem Cell Transplantation in Severe Aplastic Anemia Dr. D. Goodyear MD, FRCPC Division of Hematology and Hematological Malignancies, University of Calgary 1 of 11 Introduction Most cases of aplastic anemia

More information

STEM CELL FELLOWSHIP

STEM CELL FELLOWSHIP Module I: The Basic Principles of Stem Cells 1. Basics of Stem Cells a. Understanding the development of embryonic stem cells i. Embryonic stem cells ii. Embryonic germ cells iii. Differentiated stem cell

More information

»medical programs and services. transfusion medicine fellowship program

»medical programs and services. transfusion medicine fellowship program »medical programs and services transfusion medicine fellowship program new york blood center transfusion medicine fellowship program» Experience at one of the largest nonprofit, community-based blood centers

More information

P R E S S K I T 2013 TABLE OF CONTENTS. About the European Group for Blood and Marrow Transplantation

P R E S S K I T 2013 TABLE OF CONTENTS. About the European Group for Blood and Marrow Transplantation TABLE OF CONTENTS About the European Group for Blood and Marrow Transplantation Haematopoietic Stem Cell Transplantation (HSCT): Key facts & figures EBMT Data - A foundation for cutting-edge research Clinical

More information

CORD BLOOD BANKING IN BRAZIL HOSPITAL ISRAELITA ALBERT EINSTEIN S EXPERIENCE

CORD BLOOD BANKING IN BRAZIL HOSPITAL ISRAELITA ALBERT EINSTEIN S EXPERIENCE CORD BLOOD BANKING IN BRAZIL HOSPITAL ISRAELITA ALBERT EINSTEIN S EXPERIENCE JOSÉ MAURO KUTNER, MD MEDICAL DIRECTOR BLOOD BANK Brazil - South America BARCELONA * * SÃO PAULO Brazil - South America Brazil

More information

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program Cord Blood: that other stem cell source Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program CBMTG April 2012 The problem: In order to perform a BMT from one person to another one needs

More information

Yvette Marie Miller, M.D. Executive Medical Officer American Red Cross October 20, 2012 45 th Annual Great Lakes Cancer Nursing Conference Troy, MI

Yvette Marie Miller, M.D. Executive Medical Officer American Red Cross October 20, 2012 45 th Annual Great Lakes Cancer Nursing Conference Troy, MI Yvette Marie Miller, M.D. Executive Medical Officer American Red Cross October 20, 2012 45 th Annual Great Lakes Cancer Nursing Conference Troy, MI Overview of Hematology, http://www.nu.edu.sa/userfiles/mhmorsy/h

More information

Umbilical Cord Blood Stem Cells Current Status & Future Potential

Umbilical Cord Blood Stem Cells Current Status & Future Potential Umbilical Cord Blood Stem Cells Current Status & Future Potential Natasha Ali Assistant Professor Haematology Department of Pathology & Laboratory Medicine/Oncology The Aga Khan University Email: natasha.ali@aku.edu

More information

On April 4, a group of physicians at the 37th annual

On April 4, a group of physicians at the 37th annual By Ronale Tucker Rhodes, MS Better gene sampling and newer transplant regimens are making stem cell transplantation possible for a host of disease states that previously were rarely considered for this

More information

Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants)

Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants) Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants) What we ll cover here This document reviews bone marrow transplants and different types of stem cell transplants used to

More information

CORD BLOOD EVALUATION

CORD BLOOD EVALUATION CORD BLOOD EVALUATION Principle: When there is incompatibility between a mother s antibodies and an infant s red blood cell antigens, the infant is at risk of developing Hemolytic Disease of the Fetus

More information

Cord Blood: Thawing & Infusion Practical Methods

Cord Blood: Thawing & Infusion Practical Methods Cord Blood: Thawing & Infusion Practical Methods Donna M Regan, MT(ASCP)SBB St. Louis Cord Blood Bank @ SSM Cardinal Glennon Children s s Medical Center Objectives Present variety of product configurations

More information

PT CordLife Indonesia Premium Cordblood Bank. PT CordLife Indonesia Premium Cordblood Bank

PT CordLife Indonesia Premium Cordblood Bank. PT CordLife Indonesia Premium Cordblood Bank Cordblood Stem Cells and The Role of Cordblood Bank in Supporting Stem Cells Research Presentation Overview Company profile Haematopoietic stem cells in cordblood What we can do to help 1 2 PT CordLife

More information

Blood and Marrow Stem Cell Transplantation

Blood and Marrow Stem Cell Transplantation Blood and Marrow Stem Cell Transplantation Printing of this publication made possible by an education grant from Table of Contents Introduction 2 Overview of Stem Cell Transplantation 3 Normal Blood and

More information

Role of the Medical Director

Role of the Medical Director Role of the Medical Director Beth Shaz, MD Assistant Professor, Emory University School of Medicine Director, Transfusion Services, Grady Memorial Hospital Atlanta, GA 1.1.1 Medical Director Responsibilities

More information

14.0 Stem Cell Laboratory Services

14.0 Stem Cell Laboratory Services Laboratory Services Contact Information: To inquire about assisting with surgical harvesting of bone marrow, cellular therapy (CT) product processing, cryopreservation, storage, or any other lab services,

More information

Enumeration and Viability of Nucleated Cells from Bone Marrow, Cord Blood, and Mobilized Peripheral Blood

Enumeration and Viability of Nucleated Cells from Bone Marrow, Cord Blood, and Mobilized Peripheral Blood Application Note Primary Cell Analysis Enumeration and Viability of Nucleated Cells from Bone Marrow, Cord Blood, and Mobilized Peripheral Blood Cell Viability Introduction: Bone Marrow, Cord Blood, Stem

More information

Selecting an appropriately matched donor for hematopoietic

Selecting an appropriately matched donor for hematopoietic Transplant Outcomes in Acute Leukemia (I) Mary Eapen a and John E. Wagner b Umbilical cord blood (UCB) has gradually emerged over the last decade as an alternative source of hematopoietic cells for transplantation

More information

Recommendations to Transplant Centres Performing Cord Blood Transplants. Why Choosing the Right Thaw Method Could Save a Patient s Life

Recommendations to Transplant Centres Performing Cord Blood Transplants. Why Choosing the Right Thaw Method Could Save a Patient s Life Recommendations to Transplant Centres Performing Cord Blood Transplants Vicki Antonenas Why Choosing the Right Thaw Method Could Save a Patient s Life Lynn O Donnell (USA) 1 The process of receiving, testing

More information

Donation of Umbilical Cord Blood. A precious life offer. for everyone!

Donation of Umbilical Cord Blood. A precious life offer. for everyone! Donation of Umbilical Cord Blood A precious life offer for everyone! Donation of Umbilical Cord Blood A precious life offer for everyone! Page 3 Hellenic Cord Blood Bank Page 4 Haematopoietic Progenitor

More information

Transmedcon 2014. Ahmedabad, Gujarat November 14-16, 2014

Transmedcon 2014. Ahmedabad, Gujarat November 14-16, 2014 FACT Accreditation for Cord Blood Banks and Cellular Therapy Nadim Mahmud, MD, PhD Associate Professor of Medicine Division of Hematology/Oncology Director, Hospital Stem Cell Laboratory Blood & Marrow

More information

HAEMOPHILIA & UMBILICAL CORD BLOOD TRANSPLANT

HAEMOPHILIA & UMBILICAL CORD BLOOD TRANSPLANT HAEMOPHILIA & UMBILICAL CORD BLOOD TRANSPLANT Haemostatic System in Body Blood vessels Platelets Plasma coagulation system Proteolytic or Fibrinolytic system How Bleeding Stops Vasoconstriction Platelet

More information

Donor Adverse Events

Donor Adverse Events Donor Adverse Events Common terminology Frequency Risk factors Hold still, Mrs. Brown, while I draw your blood Mindy Goldman, MD Canadian Blood Services IHN Seminar, Paris March 11, 2016 Outline Donor

More information

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research infoaging guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research WHAT ARE STEM CELLS? Stem cells are cells that, in cell cultures

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_epithelial_ovarian_cancer 2/2001 11/2015 11/2016 11/2015 Description

More information

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION Chapter 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION 1.1 OVERVIEW OF THE CORD BLOOD TRANSPLANTATION STUDY Bone marrow transplantation

More information

It s not something you want to think about, but it s something you want to prepare for.

It s not something you want to think about, but it s something you want to prepare for. It s not something you want to think about, but it s something you want to prepare for. StemCyte cord blood banking offers your family a new lifesaving treatment alternative Why Bank Take the once-in-alifetime

More information

Peripheral Blood Stem Cell (PBSC) Collections: Why, What, When. Objectives. Sources of Stem Cells

Peripheral Blood Stem Cell (PBSC) Collections: Why, What, When. Objectives. Sources of Stem Cells Peripheral Blood Stem Cell (PBSC) Collections: Why, What, When Objectives Why do need stem cell transplants What type of cells are we using for stem cell transplants When and how we collect peripheral

More information

CIRCULAR OF INFORMATION FOR THE USE OF CELLULAR THERAPY PRODUCTS

CIRCULAR OF INFORMATION FOR THE USE OF CELLULAR THERAPY PRODUCTS CIRCULAR OF INFORMATION FOR THE USE OF CELLULAR THERAPY PRODUCTS The online version of this Circular of Information is provided for educational purposes. Printed copies of the Circular are intended to

More information