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1 FEMTOSECOND VERSUS MANUAL CATARACT SURGERY - REFRACTIVE OUTCOMES FEMTOSECOND VERSUS MANUAL CATARACT SURGERY - REFRACTIVE OUTCOMES Jack T. Holladay, MD, MSEE, FACS Clinical Professor of Ophthalmology Baylor College of Medicine a Novartis company Jack T. Holladay, MD, MSEE, FACS Clinical Professor of Ophthalmology Baylor College of Medicine a Novartis company Financial Disclosure I have the following financial interests or relationships to disclose: Acufocus Consultant Alcon Consultant AMO Consultant Elenza Consultant Oculus Consultant Visiometrics Consultant Wavetec Consultant Zeiss Consultant Collaborators Cesar Espiritu MD Manila, Philippines Chairman of The Department of Ophthalmology Manila Doctors Hospital Medical Director of The American Eye Center Robert Cionni, MD Salt Lake City Medical Director of The Eye Institute of Utah LENSX Alcon Laboratories, Irvine, California Hadi Srass, MS Melvin Sarayba, OD Ron Kurtz, MD LenSx Femtosecond Cataract Surgery Outcomes Page 1 of 5

2 Treatment of Pre-Existing Astigmatism Microscope, Guidance & Registration Bio-metric Measurement & Iris Reference Device Advanced Surgical Planner Cataract and refractive surgeons report that between 5 and 30% of their patients require LASIK, LRI or some other secondary enhancement procedure in order to improve their visual outcomes. 20 LenSx Laser Microscope, Guidance & Registration Pre Op Bio-metric Measurement & Iris Reference Device Advanced Surgical Planner Advanced Astigmatism Planner Expanded Professional Edition Windows Data Base Program for Standard and Advanced IOL Calculations LenSx Femtosecond Cataract Surgery Outcomes Page 2 of 5

3 VERION: Surgical Plan to Operating Microscope VERION: Surgical Plan to LenSx Femtosecond 9 Improved Refractive Cataract Surgery Address Major Requirements for Improved Refractive Procedure Clinical Study -- Methodology Prospective Study Espiritu (n= 40) Average SIA used 0.38D Retrospective Study Cionni (n = 37) Average SIA used 0.49D IOL Position Predictability Uniform Shape and Size Capsulotomy Corneal Astigmatism Reproducible Corneal Entry and Arcuate Incisions Early Wow Factor Reduced Phaco Power and Corneal Edema Cataract Procedure with paired Arcuate of Corneal Incisions Arcuate incisions zone: mm Arcuate incisions depth: 80 90% Norrby SJ, J Cataract Refract Surg 2008;34: Hill WJ, J Cataract Refract Surg 2008;34: Devgan U, Current Opinions in Ophthalmology 2011;18: Arcuate Incision Length (Degrees) Formula (Function depends on Variables) Magnitude of Corneal Cylinder after Cataract Incision PreOp K s Surgically Induced Astigmatism (SIA) Magnitude & Location Age Mean K (nominal D) Arc Diameter (range from 8 to 12 mm, nominal 9 mm) Arc Depth (range from 80 to 90%, nominal 80%) Arcuate Incision Meridian (0 to 180 ) PreOP Corneal Astigmatism PreOP Corneal Astigmatism n % Mean ±SD 1.00D % 0.76 ±0.19 D D % 1.24 ±0.15 D D % 1.61 ±0.07 D 2.01D 4 5.2% 2.86 ±0.70 D % 1.13 ±0.56 D PreOP Post SIA Corneal Astigmatism n % Mean ±SD 1.00D % 0.82 ±0.13 D D % 1.26 ±0.14 D D % 1.71 ±0.14 D 2.01D 6 7.8% 2.80 ±0.74 D % 1.33 ±0.58 D LenSx Femtosecond Cataract Surgery Outcomes Page 3 of 5

4 Prediction Error (D) Cumulative Absolute Residual Refractive 3M Cumulative Absolute Residual Refractive 3M Edward Holland, MD, Stephen Lane, MD, Jeffrey D. Horn, MD, Paul Ernest, MD, Robert Arleo, MD, Kevin M. Miller, MD Ophthalmology 2010;117: Safety -- Cumulative 3M Efficacy -- Cumulative 3M LenSx Femtosecond Cataract Surgery Outcomes Page 4 of 5

5 Conclusions Pilot Study Alcon Femto LenSx System Outcomes Prediction Error Accuracy: 68% exceeds Intraoperative Aberrometry by ± 0.25 D Residual Refractive Post Op Cylinder: 73% exceeds Toric IOL by 0.50 D Safety: BSCVA equal to or better than 20/20 is 87% versus 78% for Toric IOL Efficacy: UCVA equal to or better than 20/20 is 47% versus 41% for Toric IOL And that s the point!!thank You! 10/12/2014 JTH 26!Thank You! 10/12/2014 JTH 27 LenSx Femtosecond Cataract Surgery Outcomes Page 5 of 5

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