Manufacturer Fresenius Kabi Oncology plc Fresenius Kabi Oncology Ltd. Name & Address Lion Court Village: Kishanpura UNITED KINGDOM
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1 MATERIAL SAFETY DATA SHEET SECTION 1 COMPANY INFORMATION Manufacturer Fresenius Kabi Oncology plc Fresenius Kabi Oncology Ltd. Name & Address Lion Court Village: Kishanpura Farnham Road Tehsil: Nalagarh Bordon, Hampshire Districrt: Solan,( H.P) GU35 0NF Pin Code UNITED KINGDOM INDIA Telephone Fax Emergency Emergency Non- Emergency Non- Emergency SECTION 2 PRODUCT IDENTIFICATION API name Etoposide CAS Number Chemical family Antineoplastic Agent Molecular weight Not Available Chemical formula C 29 H 32 O 13 SECTION 3 PHYSICAL DATA Description Clear, colourless to pale yellow Specific Gravity No data available ph SECTION 4 HEALTH HAZARD INFORMATION AND CLASSIFICATION Overview Occupational Hazard Cautions Page 1 R22 harmful if swallowed R60 may impair fertility R21 harmful to skin Not been fully investigated Pre-existing hypersensitivity to Etoposide or any component of formulation. Preexisting skin and respiratory conditions
2 SECTION 5 FIRST AID PRECAUTIONS Eye Contact Skin Contact Inhalation Ingestion Flush immediately with plenty of water Rinse immediately with plenty of water and seek medical advice Remove to fresh air. Call a physician immediately. Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Consult a physician. SECTION 6 FIRE PROTECTION Fire & Explosion Hazard Extinguishing Media Special fire fighting procedures Keep this product away from ignition sources. Water spray, dry chemical powder, carbon dioxide or foam Use dry chemical, water sprayer, carbon dioxide and foam. SECTION 7 SPILL AND RELEASE MEASURES Spill clean-up and disposal Methods for cleaning up Wear approved respiratory protection, compatible gloves and protective clothing. Prevent product from entering drains. Wash spilt side with soap and water with absorbent SECTION 8 HANDLING AND STORAGE Handling Avoid all contacts and inhalation of dust, fumes, mist and vapors Storage Store at controlled room temperature C (59-86 F) Technical measures storage Store in controlled temperature Page 2
3 SECTION 9 EXPOSURE CONTROL AND PERSONAL PROTECTION Occupational Exposure Limit Skin Protection Eye Protection Respiratory protection. Hand protection Engineering Measures Wear overall or laboratory coat buttoned to neck Use safety glasses Use NIOSH approved respirator Disposable latex gloves Handle in type II biological safety hood or in a well-ventilated area SECTION 10 STABILITY AND REACTIVITY Stability Hazardous Polymerization Hazardous decomposition products Stable Emit acid smoke and toxi8c fumes SECTION 11 ECOLOGICAL INFORMATION Environmental Information Page 3
4 SECTION 12 TOXICOLOGICAL INFORMATION Acute toxicity Signs & symptoms Of exposure & Overexposure Developmental Toxicity Carcinogenic Effects Fever and infection, nausea, vomiting, transient hypotension, anaphylactic like reactions, back pain, loss of consciousness, rash, reversible alopecia, after taste, abdominal pain, constipation, dysphagia and transient cortical blindness Not available Known to produce a variety of chromosomal aberrations. Studies on animals have not been performed to evaluate carcinogenic potential. SECTION 13 WASTE DISPOSAL METHODS Disposal consideration Dispose material as per local, state and federal regulatory procedures and laws Page 4
5 SECTION 14 TRANSPORTATION INFORMATION UD/NA No. UN 1170 U.S Dot Hazard Class Proper Shipping Name Shipping Label Packaging Group Hazard Class 3 Flammable Liquid Ethyl alcohol solution Flammable Liquid III SECTION 15 REGULATORY INFORMATION Not available DISCLAIMER The information and recommendations contain in this document are based upon tests believed to be reliable. However, Fresenius Kabi Oncology does not guarantee their accuracy or completeness NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOOD, THE MERCHANTABILITY OF THE GOODS, OR THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE. Fresenius Kabi Oncology assumes no responsibility for results obtained or for incidental or consequential damages, including lost profits, arising from the use of this data. No warranty against infringement of any patent, copyright or trademark is made or implied. Page 5
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